SIMILAR PATTERNS OF AMINO ACIDS FOR 5H5F_A_SAMA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a33 PEPTIDYLPROLYL
ISOMERASE

(Brugia malayi) 		PF00160
(Pro_isomerase) 		5 PHE A  64
ILE A  15
GLY A  17
ARG A  22
LEU A  11
 None
 1.12A 5h5fA-1a33A:
undetectable		 5h5fA-1a33A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3x PYRUVATE KINASE

(Saccharomyces
cerevisiae) 		PF00224
(PK)
PF02887
(PK_C) 		5 ILE A 420
GLY A 438
ARG A 415
LEU A 473
ALA A 467
 None
 1.11A 5h5fA-1a3xA:
undetectable		 5h5fA-1a3xA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hz4 MALT REGULATORY
PROTEIN

(Escherichia
coli) 		no annotation 5 GLY A 186
ASP A 187
ARG A 363
LEU A 362
ALA A 338
 None
 1.08A 5h5fA-1hz4A:
undetectable		 5h5fA-1hz4A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsx GLUCOSE-INHIBITED
DIVISION PROTEIN B

(Escherichia
coli) 		PF02527
(GidB) 		5 LEU A 199
ILE A 173
ASP A 171
ARG A 197
ALA A 163
 None
 1.05A 5h5fA-1jsxA:
1.6		 5h5fA-1jsxA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT

(Sterkiella nova) 		PF02765
(POT1) 		5 PHE A 136
ILE A 120
ASP A 118
LEU A  83
ALA A  98
 None
 1.17A 5h5fA-1k8gA:
undetectable		 5h5fA-1k8gA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		5 LEU A 423
ILE A 391
GLY A 387
LEU A 252
ALA A 247
 None
None
None
OCT  A 502 ( 4.9A)
None
 1.04A 5h5fA-1kplA:
undetectable		 5h5fA-1kplA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 LEU A 412
GLY A 378
ASP A 377
LEU A 312
ALA A 409
 None
 1.13A 5h5fA-1m2wA:
undetectable		 5h5fA-1m2wA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 LEU B 571
GLY B 588
ASP B 587
LEU B 575
MET B 600
 None
 1.02A 5h5fA-1t3qB:
undetectable		 5h5fA-1t3qB:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE

(Escherichia
coli) 		PF03411
(Peptidase_M74) 		5 PRO A 217
ILE A  45
GLY A  70
ASP A  49
ARG A 215
 None
 0.95A 5h5fA-1u10A:
undetectable		 5h5fA-1u10A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u61 HYPOTHETICAL PROTEIN

(Bacillus cereus) 		PF00636
(Ribonuclease_3) 		5 ILE A 103
GLY A  16
ASP A  17
ARG A  75
ALA A   4
 None
 1.03A 5h5fA-1u61A:
undetectable		 5h5fA-1u61A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450

(Sulfurisphaera
tokodaii) 		PF00067
(p450) 		5 LEU A 207
ILE A 124
ASP A 142
LEU A 206
ALA A 210
 None
None
None
HEM  A 410 ( 4.8A)
HEM  A 410 (-4.2A)
 1.11A 5h5fA-1ue8A:
undetectable		 5h5fA-1ue8A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujn DEHYDROQUINATE
SYNTHASE

(Thermus
thermophilus) 		PF01761
(DHQ_synthase) 		5 PRO A 273
GLY A 178
ASP A 183
LEU A 271
ALA A 259
 None
 1.15A 5h5fA-1ujnA:
undetectable		 5h5fA-1ujnA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE

(Aeropyrum
pernix) 		PF00793
(DAHP_synth_1) 		5 LEU A  69
GLY A 238
ASP A 237
LEU A 103
ALA A  66
 None
 1.12A 5h5fA-1vs1A:
undetectable		 5h5fA-1vs1A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8s FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS I

(Thermoproteus
tenax) 		PF01791
(DeoC) 		5 LEU A 104
ILE A  76
GLY A  57
ASP A  56
ALA A  65
 None
 1.04A 5h5fA-1w8sA:
undetectable		 5h5fA-1w8sA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aps PROTEIN (CU,ZN
SUPEROXIDE
DISMUTASE)

(Actinobacillus
pleuropneumoniae) 		PF00080
(Sod_Cu) 		5 LEU A 130
GLY A 105
ASP A 106
ARG A 126
LEU A  15
 None
None
ZN  A 400 (-2.2A)
None
None
 1.16A 5h5fA-2apsA:
undetectable		 5h5fA-2apsA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx9 ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  66
GLY A 247
ASP A 246
ARG A  69
LEU A  70
 None
 1.14A 5h5fA-2cx9A:
undetectable		 5h5fA-2cx9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		5 LEU A 195
PHE A 222
ILE A  31
ARG A  68
ALA A 209
 None
 1.12A 5h5fA-2d4eA:
3.4		 5h5fA-2d4eA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i76 HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF10728
(DUF2520) 		5 PHE A 124
GLY A 128
ASP A 129
ARG A 100
ALA A 140
 None
 1.04A 5h5fA-2i76A:
undetectable		 5h5fA-2i76A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE

(Pseudomonas
putida) 		PF01323
(DSBA) 		5 GLY A 174
ASP A 175
ARG A 183
LEU A 184
MET A 171
 None
 1.13A 5h5fA-2imeA:
undetectable		 5h5fA-2imeA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kaf NON-STRUCTURAL
PROTEIN 3

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF12124
(Nsp3_PL2pro) 		5 LEU A  33
PHE A  32
GLY A  54
ARG A  35
LEU A  66
 None
 1.01A 5h5fA-2kafA:
undetectable		 5h5fA-2kafA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1z PHOSPHORIBOSYLTRANSF
ERASE

(Corynebacterium
diphtheriae) 		PF00156
(Pribosyltran) 		5 LEU A  10
ILE A 168
ASP A 149
LEU A  14
ALA A  38
 None
 0.95A 5h5fA-2p1zA:
undetectable		 5h5fA-2p1zA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyw UNCHARACTERIZED
PROTEIN

(Arabidopsis
thaliana) 		PF01636
(APH) 		5 LEU A 177
ILE A 235
ARG A 230
ARG A 179
LEU A 180
 None
None
None
None
SR1  A 998 ( 4.9A)
 1.15A 5h5fA-2pywA:
undetectable		 5h5fA-2pywA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6z UPF0341 PROTEIN IN
RSP 3' REGION

(Neisseria
gonorrhoeae) 		PF04445
(SAM_MT) 		5 ILE A 125
GLY A 124
ASP A 123
ARG A 126
ALA A  92
 None
 1.16A 5h5fA-2r6zA:
1.8		 5h5fA-2r6zA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb9 HYPE PROTEIN

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A 275
ILE A 303
GLY A 304
ARG A 220
LEU A 219
 None
 1.10A 5h5fA-2rb9A:
undetectable		 5h5fA-2rb9A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyl 4-HYDROXYPHENYLACETA
TE-3-HYDROXYLASE

(Thermus
thermophilus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		5 GLY A 443
ASP A 444
ARG A 447
LEU A 358
ALA A 285
 FAD  A 600 (-3.3A)
FAD  A 600 (-3.0A)
FAD  A 600 (-3.3A)
None
None
 0.78A 5h5fA-2yylA:
undetectable		 5h5fA-2yylA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu MUS81 PROTEIN
CROSSOVER JUNCTION
ENDONUCLEASE EME1

(Danio rerio;
Homo sapiens) 		PF02732
(ERCC4)
PF02732
(ERCC4) 		5 LEU B 359
GLY A 456
ASP A 455
LEU B 361
ALA B 421
 None
 1.12A 5h5fA-2ziuB:
undetectable		 5h5fA-2ziuB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 LEU A 401
PRO A 400
ILE A 390
GLY A 385
ASP A 387
 None
 1.12A 5h5fA-3cttA:
undetectable		 5h5fA-3cttA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Homo sapiens) 		PF00305
(Lipoxygenase) 		5 PHE A 534
GLY A 608
ARG A 628
LEU A 652
ALA A 538
 None
 1.04A 5h5fA-3d3lA:
undetectable		 5h5fA-3d3lA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e35 UNCHARACTERIZED
PROTEIN SCO1997

(Streptomyces
coelicolor) 		PF09754
(PAC2) 		5 LEU A 221
ILE A 156
GLY A 155
LEU A 239
ALA A 217
 None
 1.01A 5h5fA-3e35A:
undetectable		 5h5fA-3e35A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG

(Sulfolobus
solfataricus) 		PF01890
(CbiG_C)
PF11760
(CbiG_N) 		5 ILE A 235
GLY A 234
ASP A 233
ARG A 256
ALA A 302
 None
None
None
None
SO4  A   3 (-3.8A)
 1.10A 5h5fA-3eeqA:
2.1		 5h5fA-3eeqA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl1 HEAT SHOCK PROTEIN
SSB1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		5 LEU A 240
ASP A 288
ARG A 265
LEU A 300
ALA A 273
 None
MG  A 703 ( 3.0A)
CL  A 711 ( 4.0A)
None
None
 1.10A 5h5fA-3gl1A:
undetectable		 5h5fA-3gl1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 108
ILE A 270
ASP A 297
LEU A  40
ALA A 111
 None
 1.17A 5h5fA-3i6tA:
undetectable		 5h5fA-3i6tA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j26 CAPSID PROTEIN V20

(Mimivirus-dependent
virus Sputnik) 		no annotation 5 LEU A 180
PHE A 171
ASP A 161
ARG A  95
ALA A 174
 None
 1.17A 5h5fA-3j26A:
undetectable		 5h5fA-3j26A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mb2 4-OXALOCROTONATE
TAUTOMERASE FAMILY
ENZYME - BETA
SUBUNIT

(Chloroflexus
aurantiacus) 		no annotation 5 LEU B   3
ILE B  33
GLY B  34
LEU B  42
ALA B  25
 None
 1.13A 5h5fA-3mb2B:
undetectable		 5h5fA-3mb2B:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4k RNA
METHYLTRANSFERASE

(Yersinia pestis) 		PF00588
(SpoU_methylase) 		5 LEU A  83
PHE A 104
ARG A 126
MET A 136
ALA A 141
 SAH  A 201 (-4.1A)
SAH  A 201 (-4.9A)
None
SAH  A 201 (-3.9A)
SAH  A 201 ( 4.0A)
 0.96A 5h5fA-3n4kA:
9.7		 5h5fA-3n4kA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbe RICIN B-LIKE LECTIN

(Clitocybe
nebularis) 		PF14200
(RicinB_lectin_2) 		5 LEU A 139
ILE A 126
GLY A  34
ASP A  20
ALA A  13
 None
None
None
DLD  A 580 (-2.8A)
None
 0.86A 5h5fA-3nbeA:
undetectable		 5h5fA-3nbeA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3noq THIJ/PFPI FAMILY
PROTEIN

(Pseudomonas
fluorescens) 		PF01965
(DJ-1_PfpI) 		5 ILE A 156
GLY A 155
ASP A  17
LEU A  28
ALA A 163
 None
None
EDO  A 604 ( 4.6A)
None
None
 1.03A 5h5fA-3noqA:
undetectable		 5h5fA-3noqA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		5 LEU A 305
ILE A 314
GLY A 315
ASP A 342
ALA A 266
 None
None
None
MG  A 492 ( 4.1A)
None
 1.17A 5h5fA-3rreA:
2.1		 5h5fA-3rreA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwl CYTOCHROME P450
ALKANE HYDROXYLASE 1
CYP153A7

(Sphingopyxis
macrogoltabida) 		PF00067
(p450) 		5 LEU A  96
ILE A  88
GLY A  87
ASP A  86
LEU A  98
 None
 1.16A 5h5fA-3rwlA:
undetectable		 5h5fA-3rwlA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc8 LEUCINE
AMINOPEPTIDASE

(Parabacteroides
distasonis) 		PF04389
(Peptidase_M28) 		5 LEU A 219
GLY A 144
ASP A 143
LEU A 155
ALA A 121
 None
 0.81A 5h5fA-3tc8A:
undetectable		 5h5fA-3tc8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tev GLYCOSYL HYROLASE,
FAMILY 3

(Deinococcus
radiodurans) 		PF00933
(Glyco_hydro_3) 		6 ILE A 256
GLY A 254
ASP A 253
ARG A 247
LEU A 131
ALA A 174
 None
 1.30A 5h5fA-3tevA:
undetectable		 5h5fA-3tevA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 GLY A 198
ASP A 197
ARG A 192
LEU A 216
ALA A 244
 None
 1.13A 5h5fA-3u1kA:
undetectable		 5h5fA-3u1kA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v98 ARACHIDONATE
5-LIPOXYGENASE

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 PHE A 544
GLY A 618
ARG A 638
LEU A 662
ALA A 548
 None
 1.03A 5h5fA-3v98A:
undetectable		 5h5fA-3v98A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Mycobacterium
tuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A 101
ILE A 147
GLY A 145
LEU A 275
ALA A 274
 None
 1.09A 5h5fA-3zhyA:
undetectable		 5h5fA-3zhyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 5 LEU A 256
ILE A 307
GLY A 311
ARG A 254
ALA A 260
 None
 1.12A 5h5fA-4btpA:
undetectable		 5h5fA-4btpA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 LEU A 414
ILE A 124
ASP A 195
LEU A 404
ALA A 413
 None
 1.17A 5h5fA-4c30A:
undetectable		 5h5fA-4c30A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00180
(Iso_dh) 		5 ILE A 259
GLY A 260
ASP A 333
LEU A 122
ALA A 102
 None
 1.05A 5h5fA-4iwhA:
2.1		 5h5fA-4iwhA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2u ENOYL-COA HYDRATASE

(Rhodobacter
sphaeroides) 		PF16113
(ECH_2) 		5 LEU A 105
ILE A 132
GLY A 170
ASP A 173
ARG A 182
 None
 1.12A 5h5fA-4j2uA:
undetectable		 5h5fA-4j2uA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1k D-ALANINE--D-ALANINE
LIGASE

(Xanthomonas
oryzae) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 LEU A  40
PHE A  57
GLY A  12
LEU A   8
ALA A  24
 None
 1.11A 5h5fA-4l1kA:
undetectable		 5h5fA-4l1kA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvo SUBTILISIN-LIKE
SERINE PROTEASE

(Plasmodium
falciparum) 		PF00082
(Peptidase_S8) 		5 LEU A 570
GLY A 345
ASP A 347
LEU A 645
ALA A 584
 None
 1.07A 5h5fA-4lvoA:
undetectable		 5h5fA-4lvoA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9p FILAMIN-A

(Homo sapiens) 		PF00630
(Filamin) 		5 ILE A 663
GLY A 588
ARG A 664
MET A 660
ALA A 644
 None
 1.16A 5h5fA-4m9pA:
undetectable		 5h5fA-4m9pA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mm0 P450-LIKE
MONOOXYGENASE

(Streptomyces
griseoviridis) 		PF00067
(p450) 		6 LEU A  46
ILE A 294
GLY A 295
ARG A  28
LEU A  27
ALA A  34
 None
 1.28A 5h5fA-4mm0A:
undetectable		 5h5fA-4mm0A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4osp OXYGENASE-REDUCTASE

(Streptomyces
fradiae) 		PF13561
(adh_short_C2) 		5 LEU A  94
GLY A 233
ASP A 234
ARG A 237
LEU A  91
 None
 1.10A 5h5fA-4ospA:
2.6		 5h5fA-4ospA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py3 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS

(Bartonella sp.
1-1C) 		PF02661
(Fic) 		5 LEU A 170
PHE A 167
ILE A 214
LEU A 130
ALA A 142
 None
 1.12A 5h5fA-4py3A:
undetectable		 5h5fA-4py3A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py3 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS

(Bartonella sp.
1-1C) 		PF02661
(Fic) 		5 PHE A 167
ILE A 214
ASP A 216
LEU A 130
ALA A 142
 None
 1.17A 5h5fA-4py3A:
undetectable		 5h5fA-4py3A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfk ABC TRANSPORTER
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Pseudoalteromonas
sp. SM9913) 		no annotation 5 LEU H 500
ILE H 421
GLY H 422
ARG H 425
LEU H 448
 None
 1.15A 5h5fA-4qfkH:
undetectable		 5h5fA-4qfkH:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 LEU A  79
ILE A  91
ASP A 130
LEU A  84
ALA A 142
 None
 1.14A 5h5fA-4qk3A:
undetectable		 5h5fA-4qk3A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D

(Homo sapiens) 		PF12706
(Lactamase_B_2) 		5 PRO A 212
PHE A 210
GLY A 283
ASP A 284
LEU A 230
 None
None
None
ZN  A 502 (-2.5A)
None
 1.16A 5h5fA-4qn9A:
undetectable		 5h5fA-4qn9A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 PRO A  55
GLY A 137
ASP A 115
MET A 140
ALA A 143
 None
 1.00A 5h5fA-4r1dA:
1.8		 5h5fA-4r1dA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg6 CELL DIVISION CYCLE
PROTEIN 27 HOMOLOG

(Homo sapiens) 		PF00515
(TPR_1)
PF12895
(ANAPC3)
PF13181
(TPR_8) 		5 LEU A  41
ILE A  12
ASP A  23
LEU A  60
ALA A  45
 None
 1.17A 5h5fA-4rg6A:
undetectable		 5h5fA-4rg6A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		5 ILE B 144
GLY B 166
ARG B 142
ARG B 170
LEU B 191
 None
 1.13A 5h5fA-4rs1B:
undetectable		 5h5fA-4rs1B:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzn PROTEIN HTP-2

(Caenorhabditis
elegans) 		PF02301
(HORMA) 		5 LEU A 141
PHE A 153
GLY A 103
ASP A 102
ALA A 139
 None
 1.05A 5h5fA-4tznA:
undetectable		 5h5fA-4tznA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uc7 NUCLEOPROTEIN

(Human
orthopneumovirus) 		PF03246
(Pneumo_ncap) 		5 LEU A 161
PHE A 243
ARG A 238
LEU A 164
ALA A 165
 None
 1.17A 5h5fA-4uc7A:
undetectable		 5h5fA-4uc7A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus) 		PF01966
(HD) 		6 LEU A 281
ILE A 333
GLY A 238
ASP A 239
LEU A 283
ALA A 300
 None
 1.20A 5h5fA-4uw2A:
undetectable		 5h5fA-4uw2A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v15 D-THREONINE ALDOLASE

(Achromobacter
xylosoxidans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		5 PRO A  56
ARG A  69
LEU A 248
MET A  43
ALA A  47
 None
 1.16A 5h5fA-4v15A:
undetectable		 5h5fA-4v15A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5w RIBULOSE
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E ACTIVASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00004
(AAA) 		5 LEU A 290
ILE A 284
GLY A 110
LEU A 342
ALA A 289
 None
None
SO4  A 401 (-3.4A)
None
None
 1.16A 5h5fA-4w5wA:
undetectable		 5h5fA-4w5wA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 150
GLY A 152
ASP A  96
ARG A 151
ALA A 171
 None
 1.12A 5h5fA-4xoxA:
1.3		 5h5fA-4xoxA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Trichophyton
rubrum) 		no annotation 5 PRO D 162
ILE D 322
GLY D 320
LEU D 159
ALA D 255
 None
 0.91A 5h5fA-4zhsD:
undetectable		 5h5fA-4zhsD:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zsx UNCHARACTERIZED
FUSION PROTEIN

(Pseudomonas
aeruginosa;
Aquifex
aeolicus) 		PF06557
(DUF1122) 		5 LEU A 218
GLY A 273
ASP A 274
ARG A 216
ALA A 232
 None
 1.14A 5h5fA-4zsxA:
undetectable		 5h5fA-4zsxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		5 LEU C 268
PRO C 539
GLY C 393
ASP C 571
ARG C 501
 None
None
None
None
NFU  C 701 (-4.6A)
 1.09A 5h5fA-5aa5C:
undetectable		 5h5fA-5aa5C:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5apg TSR3

(Vulcanisaeta
distributa) 		PF04034
(Ribo_biogen_C) 		5 LEU A  45
PRO A  47
ARG A  92
LEU A  93
ALA A 115
 EEM  A1185 (-3.9A)
EEM  A1185 (-3.9A)
None
EEM  A1185 (-3.9A)
EEM  A1185 (-3.4A)
 0.78A 5h5fA-5apgA:
7.3		 5h5fA-5apgA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT

(Corynebacterium
glutamicum) 		PF01497
(Peripla_BP_2) 		5 PHE A 248
GLY A 252
ASP A 253
LEU A 286
ALA A 281
 None
 1.17A 5h5fA-5az3A:
undetectable		 5h5fA-5az3A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF13847
(Methyltransf_31) 		5 LEU A  42
ILE A  62
GLY A  38
ARG A  88
ALA A 105
 None
 1.08A 5h5fA-5bp7A:
undetectable		 5h5fA-5bp7A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c54 DIHYDRODIPICOLINATE
SYNTHASE/N-ACETYLNEU
RAMINATE LYASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		5 LEU A 104
GLY A  42
ASP A  41
LEU A 133
ALA A 101
 None
 0.94A 5h5fA-5c54A:
2.7		 5h5fA-5c54A:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1

(Saccharomyces
cerevisiae) 		PF04252
(RNA_Me_trans) 		7 LEU A  83
PRO A  85
PHE A 104
ARG A 132
LEU A 133
MET A 138
ALA A 143
 SAH  A 301 (-4.5A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.8A)
None
SAH  A 301 (-4.0A)
SAH  A 301 (-4.9A)
SAH  A 301 ( 4.0A)
 0.34A 5h5fA-5c77A:
29.1		 5h5fA-5c77A:
91.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8w ENDOGLUCANASE

(Ganoderma
lucidum) 		PF00150
(Cellulase) 		5 ILE A 158
GLY A 160
ASP A 118
ARG A  76
ALA A 190
 None
 1.02A 5h5fA-5d8wA:
undetectable		 5h5fA-5d8wA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzz DESMOPLAKIN

(Homo sapiens) 		PF00681
(Plectin) 		5 LEU A2350
GLY A2256
ASP A2252
LEU A2367
ALA A2297
 None
 1.13A 5h5fA-5dzzA:
undetectable		 5h5fA-5dzzA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		5 LEU A 353
PHE A  67
GLY A 394
LEU A  52
ALA A  61
 None
None
HEM  A 501 (-4.0A)
None
None
 1.09A 5h5fA-5e78A:
undetectable		 5h5fA-5e78A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF03170
(BcsB) 		5 GLY B 276
ASP B 275
ARG B 257
LEU B 184
ALA B 188
 None
 1.11A 5h5fA-5ej1B:
undetectable		 5h5fA-5ej1B:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 LEU A 184
PHE A 273
ILE A 102
GLY A 103
LEU A 179
 None
None
SAH  A 401 (-4.9A)
SAH  A 401 (-3.0A)
None
 1.11A 5h5fA-5ekuA:
1.9		 5h5fA-5ekuA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 LEU D 175
PRO D 177
ASP D 392
LEU D 174
ALA D 402
 None
 1.17A 5h5fA-5fl7D:
undetectable		 5h5fA-5fl7D:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft6 CYSTEINE DESULFURASE
CSDA

(Escherichia
coli) 		PF00266
(Aminotran_5) 		5 LEU A 372
PHE A 331
GLY A 174
LEU A 352
ALA A 374
 None
 1.14A 5h5fA-5ft6A:
undetectable		 5h5fA-5ft6A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 LEU q 117
ILE q  29
GLY q  26
ASP q  25
LEU q 122
 None
 1.15A 5h5fA-5gw5q:
2.0		 5h5fA-5gw5q:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 LEU q 122
ILE q  29
GLY q  26
ASP q  25
ALA q 124
 None
 1.15A 5h5fA-5gw5q:
2.0		 5h5fA-5gw5q:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4u ENDO-BETA-1,4-GLUCAN
ASE

(Cryptopygus
antarcticus) 		PF02015
(Glyco_hydro_45) 		5 ILE A 154
GLY A 153
ARG A  10
ARG A 174
ALA A 142
 None
 1.16A 5h5fA-5h4uA:
undetectable		 5h5fA-5h4uA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hv6 PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF01326
(PPDK_N) 		5 LEU A 138
ILE A 141
GLY A 142
ASP A 144
ALA A 115
 None
 1.08A 5h5fA-5hv6A:
undetectable		 5h5fA-5hv6A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021

(Burkholderia
pseudomallei) 		PF00282
(Pyridoxal_deC) 		5 PRO A 276
ILE A 319
GLY A 316
ARG A 314
ALA A  71
 None
 1.15A 5h5fA-5k1rA:
undetectable		 5h5fA-5k1rA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 764
ILE A 153
GLY A 756
ARG A 155
LEU A 815
 None
 1.15A 5h5fA-5lohA:
undetectable		 5h5fA-5lohA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpv -

(-) 		no annotation 6 LEU D  80
ILE D  42
GLY D  43
ARG D  82
LEU D  83
ALA D  36
 None
 1.49A 5h5fA-5mpvD:
undetectable		 5h5fA-5mpvD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nwm NUCLEAR RECEPTOR
COACTIVATOR 1
SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 LEU A 313
ILE B 790
GLY A 270
ASP A 267
ALA A 310
 None
 1.13A 5h5fA-5nwmA:
undetectable		 5h5fA-5nwmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tbf TRANSLATION
ELONGATION FACTOR

(Vibrio cholerae) 		PF11826
(DUF3346) 		5 LEU A 268
ILE A 262
ASP A 279
LEU A 371
ALA A 231
 None
 1.09A 5h5fA-5tbfA:
undetectable		 5h5fA-5tbfA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttx HYDROGENASE 2
MATURATION PEPTIDASE

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF01750
(HycI) 		5 PHE A  63
ILE A 123
ASP A 149
LEU A   8
ALA A  10
 None
 0.98A 5h5fA-5ttxA:
undetectable		 5h5fA-5ttxA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 PRO 5 612
GLY 5 394
ARG 5 607
ARG 5 613
LEU 5 614
 None
 1.04A 5h5fA-5udb5:
undetectable		 5h5fA-5udb5:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 LEU E 124
PHE E 156
ILE E  35
ARG E  11
ALA E 127
 None
 0.95A 5h5fA-5uj7E:
undetectable		 5h5fA-5uj7E:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 LEU E 124
PHE E 156
ILE E  35
GLY E  37
ALA E 127
 None
 1.08A 5h5fA-5uj7E:
undetectable		 5h5fA-5uj7E:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 LEU E 124
PHE E 156
ILE E  35
ARG E  11
ALA E 127
 None
 0.94A 5h5fA-5ujmE:
undetectable		 5h5fA-5ujmE:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 LEU E 124
PHE E 156
ILE E  35
GLY E  37
ALA E 127
 None
 1.08A 5h5fA-5ujmE:
undetectable		 5h5fA-5ujmE:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA

(Haemophilus
influenzae) 		PF04348
(LppC) 		5 LEU A 262
ILE A 276
GLY A 520
ASP A 522
LEU A 316
 None
 1.16A 5h5fA-5vatA:
2.6		 5h5fA-5vatA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwf -

(-) 		no annotation 5 LEU A 634
ILE A 647
GLY A 648
ARG A 629
ALA A 635
 None
 1.09A 5h5fA-6bwfA:
undetectable		 5h5fA-6bwfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n PRE-MRNA 3' END
PROCESSING PROTEIN
WDR33

(Homo sapiens) 		no annotation 5 LEU B 356
PHE B 358
ARG B 328
LEU B 381
ALA B 348
 None
 1.12A 5h5fA-6f9nB:
undetectable		 5h5fA-6f9nB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpd L-ALA-D/L-GLU
EPIMERASE

(Escherichia
coli) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY X 317
PRO X 301
THR X 121
THR X 315
 None
 1.22A 5h5fA-1jpdX:
1.8		 5h5fA-1jpdX:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 GLY A 498
PRO A 478
THR A 495
THR A 552
 None
None
GOL  A1820 ( 4.7A)
GOL  A1823 (-4.3A)
 1.22A 5h5fA-1kb0A:
undetectable		 5h5fA-1kb0A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		4 GLY B  44
PRO B  40
THR B  68
THR B 105
 None
None
None
CLP  B 498 (-4.0A)
 1.07A 5h5fA-1mioB:
1.2		 5h5fA-1mioB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npe NIDOGEN

(Mus musculus) 		PF00058
(Ldl_recept_b) 		4 GLY A 995
PRO A 970
THR A 965
THR A1008
 None
 1.23A 5h5fA-1npeA:
undetectable		 5h5fA-1npeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 GLY Q 106
PRO Q 404
THR Q 104
THR Q  99
 None
 1.28A 5h5fA-1oh2Q:
undetectable		 5h5fA-1oh2Q:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovw ENDOGLUCANASE I

(Fusarium
oxysporum) 		PF00840
(Glyco_hydro_7) 		4 GLY A 392
THR A 397
GLN A 271
THR A 125
 None
 0.87A 5h5fA-1ovwA:
undetectable		 5h5fA-1ovwA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjq SIROHEME SYNTHASE

(Salmonella
enterica) 		PF00590
(TP_methylase)
PF10414
(CysG_dimeriser)
PF13241
(NAD_binding_7)
PF14824
(Sirohm_synth_M) 		4 GLY A 335
PRO A 436
THR A 412
THR A 331
 None
None
None
ACT  A 505 (-3.4A)
 1.02A 5h5fA-1pjqA:
2.5		 5h5fA-1pjqA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q14 HST2 PROTEIN

(Saccharomyces
cerevisiae) 		PF02146
(SIR2) 		4 GLY A  32
PRO A 235
THR A 224
THR A 114
 None
 1.28A 5h5fA-1q14A:
0.8		 5h5fA-1q14A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q33 ADP-RIBOSE
PYROPHOSPHATASE

(Homo sapiens) 		PF00293
(NUDIX) 		4 GLY A 158
PRO A  71
THR A 275
THR A 100
 None
 1.27A 5h5fA-1q33A:
undetectable		 5h5fA-1q33A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q44 STEROID
SULFOTRANSFERASE

(Arabidopsis
thaliana) 		PF00685
(Sulfotransfer_1) 		4 GLY A  12
PRO A   8
THR A  17
GLN A  48
 None
 1.25A 5h5fA-1q44A:
undetectable		 5h5fA-1q44A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt4 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF04107
(GCS2) 		4 GLY A  15
THR A  13
GLN A  71
THR A  63
 None
 1.26A 5h5fA-1tt4A:
undetectable		 5h5fA-1tt4A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		4 PRO C 377
THR C 405
GLN C 431
THR C 426
 None
 1.27A 5h5fA-1u6gC:
undetectable		 5h5fA-1u6gC:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		4 GLY A1070
PRO A1034
THR A1068
THR A1051
 None
 1.10A 5h5fA-1ux6A:
undetectable		 5h5fA-1ux6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5f PYRUVATE OXIDASE

(Aerococcus
viridans) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLY A 215
PRO A 404
THR A 218
THR A 239
 FAD  A1601 (-2.9A)
None
None
FAD  A1601 (-2.8A)
 1.07A 5h5fA-1v5fA:
undetectable		 5h5fA-1v5fA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG

(Homo sapiens) 		PF08423
(Rad51) 		4 GLY A 333
THR A 138
GLN A 134
THR A 331
 None
 1.30A 5h5fA-1v5wA:
undetectable		 5h5fA-1v5wA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN

(Thermus
thermophilus) 		PF10432
(bact-PGI_C) 		4 GLY A 177
PRO A 165
THR A 193
THR A 181
 None
 1.26A 5h5fA-1wiwA:
undetectable		 5h5fA-1wiwA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydw AX110P-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01408
(GFO_IDH_MocA) 		4 PRO A 268
THR A 137
GLN A 306
THR A 129
 None
 1.27A 5h5fA-1ydwA:
2.5		 5h5fA-1ydwA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		4 GLY A 667
THR A 535
GLN A 645
THR A 643
 None
None
GAL  A 700 (-4.0A)
None
 1.20A 5h5fA-1z45A:
3.1		 5h5fA-1z45A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 GLY B  81
PRO B 180
GLN B 278
THR B 276
 None
 1.17A 5h5fA-2afhB:
undetectable		 5h5fA-2afhB:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csd TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 GLY A 420
PRO A 434
THR A 414
THR A 423
 None
 1.04A 5h5fA-2csdA:
undetectable		 5h5fA-2csdA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 GLY A 176
PRO A 157
THR A 161
THR A 188
 FAD  A 525 (-3.5A)
None
FAD  A 525 (-4.1A)
None
 1.00A 5h5fA-2exrA:
undetectable		 5h5fA-2exrA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 GLY X 345
PRO X 510
GLN X 355
THR X 350
 None
 1.30A 5h5fA-2iv2X:
undetectable		 5h5fA-2iv2X:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mvo PUTATIVE LIPOPROTEIN

(Microbispora
sp. ATCC
PTA-5024) 		PF10709
(DUF2511) 		4 PRO A  53
THR A  79
GLN A  60
THR A 134
 None
 1.30A 5h5fA-2mvoA:
undetectable		 5h5fA-2mvoA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq2 PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF01507
(PAPS_reduct) 		4 GLY A  54
PRO A  71
THR A  57
THR A  48
 A3P  A 999 (-3.1A)
None
None
A3P  A 999 (-3.6A)
 1.01A 5h5fA-2oq2A:
2.0		 5h5fA-2oq2A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06471
(NSP11) 		4 GLY A 169
PRO A 157
THR A 174
GLN A 159
 None
 1.07A 5h5fA-2ozkA:
undetectable		 5h5fA-2ozkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3) 		4 GLY A1090
PRO A1054
THR A1088
THR A1071
 None
None
None
NAG  A   4 (-4.4A)
 1.16A 5h5fA-2rhpA:
undetectable		 5h5fA-2rhpA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1w PDZ AND LIM DOMAIN
PROTEIN 4

(Homo sapiens) 		PF00595
(PDZ) 		4 GLY A  46
PRO A   2
GLN A  50
THR A  28
 None
 1.12A 5h5fA-2v1wA:
undetectable		 5h5fA-2v1wA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we9 MOBA-RELATED PROTEIN

(Mycobacterium
tuberculosis) 		PF12804
(NTP_transf_3) 		4 GLY A  35
PRO A  22
THR A  32
GLN A  24
 None
 1.26A 5h5fA-2we9A:
2.8		 5h5fA-2we9A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yok EXOGLUCANASE 1

(Trichoderma
harzianum) 		PF00840
(Glyco_hydro_7) 		4 GLY A 437
PRO A  43
GLN A  34
THR A 442
 None
 1.27A 5h5fA-2yokA:
undetectable		 5h5fA-2yokA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeu LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		4 GLY A 153
PRO A 224
GLN A 304
THR A 148
 None
 1.13A 5h5fA-3aeuA:
undetectable		 5h5fA-3aeuA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgk PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF01256
(Carb_kinase) 		4 GLY A 214
THR A 218
GLN A 210
THR A 212
 PO4  A 278 (-3.3A)
None
None
None
 1.16A 5h5fA-3bgkA:
3.1		 5h5fA-3bgkA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bm1 PROTEIN YDJA

(Escherichia
coli) 		PF00881
(Nitroreductase) 		4 GLY A 156
PRO A  83
THR A  91
THR A 137
 None
 1.18A 5h5fA-3bm1A:
undetectable		 5h5fA-3bm1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnj CHOLESTEROL OXIDASE

(Streptomyces
sp. SA-COO) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A 315
PRO A 448
THR A 295
THR A 387
 None
 1.14A 5h5fA-3cnjA:
1.9		 5h5fA-3cnjA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwo PROBABLE OUTER
MEMBRANE PROTEIN

(Pseudomonas
aeruginosa) 		PF03349
(Toluene_X) 		4 PRO X  98
THR X   7
GLN X 116
THR X 147
 None
 1.02A 5h5fA-3dwoX:
undetectable		 5h5fA-3dwoX:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE

(Neisseria
meningitidis) 		PF01225
(Mur_ligase)
PF08245
(Mur_ligase_M) 		4 GLY A  16
PRO A  38
THR A  12
GLN A  42
 None
 1.30A 5h5fA-3eagA:
4.4		 5h5fA-3eagA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfq UNCHARACTERIZED
PROTEIN LP_2219

(Lactobacillus
plantarum) 		PF10282
(Lactonase) 		4 GLY A  17
PRO A  87
THR A  39
THR A   9
 None
 1.26A 5h5fA-3hfqA:
undetectable		 5h5fA-3hfqA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it7 PROTEASE LASA

(Pseudomonas
aeruginosa) 		PF01551
(Peptidase_M23) 		4 GLY A 104
THR A  48
GLN A  84
THR A 108
 None
 1.04A 5h5fA-3it7A:
undetectable		 5h5fA-3it7A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 4 GLY B 200
PRO B1213
GLN B 173
THR B 175
 None
 1.26A 5h5fA-3iz3B:
undetectable		 5h5fA-3iz3B:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq4 GASTRIC INTRINSIC
FACTOR

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		4 GLY A 391
THR A 393
GLN A 387
THR A 411
 None
None
NAG  A2002 ( 4.8A)
None
 1.03A 5h5fA-3kq4A:
undetectable		 5h5fA-3kq4A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyh MRNA-CAPPING ENZYME
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		4 GLY C  73
PRO C 221
THR C  71
GLN C 136
 None
 1.06A 5h5fA-3kyhC:
undetectable		 5h5fA-3kyhC:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6v DNA GYRASE SUBUNIT A

(Xanthomonas
campestris) 		PF03989
(DNA_gyraseA_C) 		4 GLY A 785
THR A 782
GLN A 854
THR A 857
 None
 1.24A 5h5fA-3l6vA:
undetectable		 5h5fA-3l6vA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus;
Archaeoglobus
fulgidus) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLY A 125
PRO B  59
THR A 127
THR A  24
 None
 1.28A 5h5fA-3mm5A:
undetectable		 5h5fA-3mm5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqt MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A  36
PRO A  75
THR A  32
GLN A 116
 None
 1.16A 5h5fA-3mqtA:
undetectable		 5h5fA-3mqtA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC

(Zea mays) 		PF03055
(RPE65) 		4 PRO A 469
THR A 514
GLN A 472
THR A 518
 None
 1.28A 5h5fA-3npeA:
undetectable		 5h5fA-3npeA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojl CAP5O

(Staphylococcus
aureus) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 GLY A 141
PRO A 131
THR A 139
THR A 173
 None
 1.20A 5h5fA-3ojlA:
undetectable		 5h5fA-3ojlA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 GLY B  40
PRO B  36
THR B  64
THR B 101
 None
 1.01A 5h5fA-3pdiB:
undetectable		 5h5fA-3pdiB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		4 GLY A 690
PRO A 642
THR A 688
THR A 509
 None
 1.23A 5h5fA-3poyA:
undetectable		 5h5fA-3poyA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q98 TRANSCARBAMYLASE

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 GLY A 213
PRO A  32
THR A  27
THR A 216
 None
 1.21A 5h5fA-3q98A:
undetectable		 5h5fA-3q98A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		4 GLY A 674
PRO A 626
THR A 672
THR A 493
 None
 1.25A 5h5fA-3qcwA:
undetectable		 5h5fA-3qcwA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		4 GLY A 247
PRO A 193
THR A 249
THR A  60
 PO4  A   2 (-3.3A)
None
PO4  A   2 ( 4.7A)
PO4  A   2 (-3.0A)
 1.22A 5h5fA-3qmlA:
undetectable		 5h5fA-3qmlA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s46 ALANINE RACEMASE

(Streptococcus
pneumoniae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 GLY A 262
PRO A 303
THR A 314
THR A 266
 None
 1.14A 5h5fA-3s46A:
undetectable		 5h5fA-3s46A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF12391
(PCDO_beta_N) 		4 PRO M 468
THR M 346
GLN M 530
THR M 533
 None
 1.23A 5h5fA-3t63M:
undetectable		 5h5fA-3t63M:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 GLY A 135
PRO A 302
THR A 108
GLN A 307
 None
 1.12A 5h5fA-3ttfA:
undetectable		 5h5fA-3ttfA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk6 RUVB-LIKE 2

(Homo sapiens) 		PF06068
(TIP49) 		4 GLY A 394
PRO A 361
THR A 367
THR A 397
 None
 1.27A 5h5fA-3uk6A:
undetectable		 5h5fA-3uk6A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whs GAMMA-GLUTAMYLTRANSP
EPTIDASE SMALL CHAIN

(Bacillus
subtilis) 		PF01019
(G_glu_transpept) 		4 GLY B 485
PRO B 468
THR B 403
THR B 488
 AVN  B 600 (-4.5A)
None
AVN  B 600 (-1.9A)
None
 1.26A 5h5fA-3whsB:
undetectable		 5h5fA-3whsB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg8 PENICILLIN-BINDING
PROTEIN 4

(Listeria
monocytogenes) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		4 GLY B 393
PRO B 497
THR B 395
THR B 579
 AIX  B 800 (-3.9A)
None
None
GOL  B1643 (-4.3A)
 1.29A 5h5fA-3zg8B:
undetectable		 5h5fA-3zg8B:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif PVIII

(Bovine
mastadenovirus
B) 		PF01310
(Adeno_PVIII) 		4 GLY R  22
PRO R  15
THR R  12
GLN R  14
 None
 1.14A 5h5fA-3zifR:
undetectable		 5h5fA-3zifR:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE

(Pseudogluconobacter
saccharoketogenes) 		PF13360
(PQQ_2) 		4 GLY A 252
PRO A 328
THR A 255
GLN A 325
 None
 1.20A 5h5fA-4cvcA:
undetectable		 5h5fA-4cvcA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehj PHOSPHOGLYCERATE
KINASE

(Francisella
tularensis) 		PF00162
(PGK) 		4 GLY A 316
PRO A 293
GLN A 296
THR A 327
 None
 1.29A 5h5fA-4ehjA:
2.7		 5h5fA-4ehjA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esj TYPE-2 RESTRICTION
ENZYME DPNI

(Streptococcus
pneumoniae) 		PF06044
(DpnI) 		4 GLY A 187
PRO A 114
THR A 119
THR A 189
 None
 1.23A 5h5fA-4esjA:
undetectable		 5h5fA-4esjA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana) 		PF03098
(An_peroxidase) 		4 GLY A 226
PRO A 468
THR A 231
THR A 216
 None
None
CL  A 713 ( 4.5A)
CA  A 703 (-3.6A)
 1.20A 5h5fA-4hhrA:
undetectable		 5h5fA-4hhrA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		4 GLY A 176
PRO A 379
THR A 402
GLN A 398
 TAR  A 701 (-3.7A)
None
None
None
 0.98A 5h5fA-4issA:
undetectable		 5h5fA-4issA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A3547
PRO A3629
THR A3543
THR A3164
 None
 1.22A 5h5fA-4kc5A:
undetectable		 5h5fA-4kc5A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhu 9C2 TCR GAMMA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY G 152
THR G 200
GLN G 149
THR G 146
 None
 1.20A 5h5fA-4lhuG:
undetectable		 5h5fA-4lhuG:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN

(Thermomonospora
curvata) 		PF13458
(Peripla_BP_6) 		4 GLY A  68
PRO A 122
THR A  58
GLN A  75
 None
 0.63A 5h5fA-4n03A:
undetectable		 5h5fA-4n03A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		4 GLY A   8
THR A  35
GLN A  70
THR A  96
 None
None
UD1  A 400 ( 4.0A)
UD1  A 400 (-4.1A)
 1.14A 5h5fA-4nesA:
undetectable		 5h5fA-4nesA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otu GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		4 GLY B 481
PRO B 464
THR B 399
THR B 484
 GLU  B 602 ( 4.2A)
None
GLU  B 602 (-2.7A)
None
 1.07A 5h5fA-4otuB:
undetectable		 5h5fA-4otuB:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Deinococcus
radiodurans) 		PF02540
(NAD_synthase) 		4 GLY A  57
PRO A 208
THR A  61
GLN A 101
 SO4  A 301 (-3.3A)
None
None
None
 1.05A 5h5fA-4q16A:
undetectable		 5h5fA-4q16A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6t GLYCOSYL HYDROLASE,
FAMILY 18

(Pseudomonas
protegens) 		PF00704
(Glyco_hydro_18) 		4 GLY A  40
THR A  64
GLN A  83
THR A  81
 None
 1.16A 5h5fA-4q6tA:
undetectable		 5h5fA-4q6tA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv2 UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2
MAOC FAMILY PROTEIN

(Mycolicibacterium
smegmatis;
Mycolicibacterium
smegmatis) 		PF13452
(MaoC_dehydrat_N)
PF01575
(MaoC_dehydratas) 		4 GLY B  67
PRO A  54
THR B  71
THR A  58
 None
 1.19A 5h5fA-4rv2B:
undetectable		 5h5fA-4rv2B:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvg ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Escherichia
coli) 		PF07992
(Pyr_redox_2)
PF13192
(Thioredoxin_3) 		4 GLY A  99
PRO A  70
THR A  97
THR A  18
 None
 1.23A 5h5fA-4xvgA:
undetectable		 5h5fA-4xvgA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ygt UNCHARACTERIZED
PROTEIN YJGB

(Bacillus
subtilis) 		PF14172
(DUF4309) 		4 GLY A  61
THR A  57
GLN A  68
THR A  71
 None
 1.26A 5h5fA-4ygtA:
undetectable		 5h5fA-4ygtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yr1 ALKALINE PHOSPHATASE

(Escherichia
coli) 		PF00245
(Alk_phosphatase) 		4 GLY A 170
THR A 174
GLN A 194
THR A 192
 None
 1.29A 5h5fA-4yr1A:
undetectable		 5h5fA-4yr1A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A 172
PRO A 239
GLN A 240
THR A 170
 None
 1.21A 5h5fA-5a7mA:
undetectable		 5h5fA-5a7mA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2

(Saccharomyces
cerevisiae) 		PF00909
(Ammonium_transp) 		4 GLY A  16
PRO A 121
THR A  14
THR A  21
 None
 1.06A 5h5fA-5aexA:
undetectable		 5h5fA-5aexA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyx PROTEIN CDHR2

(Mus musculus) 		PF00028
(Cadherin) 		4 GLY A 191
THR A 199
GLN A 140
THR A 135
 None
 1.25A 5h5fA-5cyxA:
undetectable		 5h5fA-5cyxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Homo sapiens) 		PF00149
(Metallophos) 		4 GLY A 292
PRO A 333
THR A  44
THR A 294
 None
 1.13A 5h5fA-5ebbA:
undetectable		 5h5fA-5ebbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Mus musculus) 		PF00149
(Metallophos) 		4 GLY A 289
PRO A 330
THR A  41
THR A 291
 None
 1.18A 5h5fA-5fcaA:
undetectable		 5h5fA-5fcaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Clostridium sp.) 		PF13561
(adh_short_C2) 		4 GLY A  24
PRO A 232
THR A 101
THR A  26
 NDP  A1265 ( 4.1A)
None
None
NDP  A1265 (-2.8A)
 1.19A 5h5fA-5g4lA:
undetectable		 5h5fA-5g4lA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gv1 ENDO-1,4-BETA-XYLANA
SE

(termite gut
metagenome) 		PF00457
(Glyco_hydro_11) 		4 GLY A 178
PRO A 160
GLN A 208
THR A 175
 None
 1.29A 5h5fA-5gv1A:
undetectable		 5h5fA-5gv1A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyg ENDO-1,4-BETA-XYLANA
SE

(termite gut
metagenome) 		PF00457
(Glyco_hydro_11) 		4 GLY A 178
PRO A 160
GLN A 208
THR A 175
 None
 1.26A 5h5fA-5gygA:
undetectable		 5h5fA-5gygA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 GLY A 671
PRO A 490
THR A 530
THR A 610
 None
 1.12A 5h5fA-5hqbA:
undetectable		 5h5fA-5hqbA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hva DR2231

(Deinococcus
radiodurans) 		PF01503
(PRA-PH) 		4 GLY A  95
PRO A  33
THR A  30
THR A  25
 None
 1.24A 5h5fA-5hvaA:
undetectable		 5h5fA-5hvaA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLY A 176
PRO A 379
THR A 402
GLN A 398
 None
 0.96A 5h5fA-5i8iA:
2.3		 5h5fA-5i8iA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 GLY b  10
PRO b 341
THR b 278
THR b  30
 None
 1.18A 5h5fA-5l9wb:
undetectable		 5h5fA-5l9wb:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 GLY b 277
PRO b 251
THR b 279
THR b  11
 ADP  b 801 (-3.3A)
None
None
ADP  b 801 (-2.9A)
 1.14A 5h5fA-5l9wb:
undetectable		 5h5fA-5l9wb:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 4 GLY A 654
PRO A 506
THR A 652
GLN A 540
 None
 1.14A 5h5fA-5mz9A:
undetectable		 5h5fA-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 GLY A  80
THR A  84
GLN A  73
THR A  60
 None
 1.29A 5h5fA-5mzsA:
undetectable		 5h5fA-5mzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN
CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1;
Rosellinia
necatrix
quadrivirus 1) 		no annotation
no annotation 		4 GLY B 646
PRO A 924
THR B 629
THR B 596
 None
 1.23A 5h5fA-5nd1B:
undetectable		 5h5fA-5nd1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndl CRH-LIKE PROTEIN

(Aspergillus
fumigatus) 		no annotation 4 GLY A 223
PRO A 156
GLN A 157
THR A 104
 None
 1.21A 5h5fA-5ndlA:
undetectable		 5h5fA-5ndlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc9 -

(-) 		no annotation 4 GLY A 202
PRO A 172
GLN A 125
THR A 120
 None
 1.16A 5h5fA-5oc9A:
undetectable		 5h5fA-5oc9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		4 GLY A 431
PRO A 481
THR A 463
GLN A 362
 None
 1.18A 5h5fA-5svcA:
undetectable		 5h5fA-5svcA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t77 PUTATIVE LIPID II
FLIPPASE MURJ

(Thermosipho
africanus) 		PF03023
(MVIN) 		4 GLY A 345
PRO A 413
THR A 349
THR A 298
 None
1PE  A 512 ( 4.3A)
None
None
 1.10A 5h5fA-5t77A:
undetectable		 5h5fA-5t77A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa2 SURFACE ANTIGEN

(Toxoplasma
gondii) 		no annotation 4 GLY A 143
PRO A 175
GLN A 240
THR A 138
 None
 1.17A 5h5fA-5wa2A:
undetectable		 5h5fA-5wa2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xil PUTATIVE PROLYL-TRNA
SYNTHETASE

(Leishmania
major) 		no annotation 4 GLY A 688
PRO A 724
GLN A 727
THR A 747
 None
 1.28A 5h5fA-5xilA:
undetectable		 5h5fA-5xilA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 GLY C1226
PRO C1158
THR C1223
GLN C1231
 None
 1.26A 5h5fA-5y3rC:
undetectable		 5h5fA-5y3rC:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4f ANKYRIN-2

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 PRO A 835
THR A 729
GLN A 766
THR A 762
 None
 1.18A 5h5fA-5y4fA:
undetectable		 5h5fA-5y4fA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4k DMSP LYASE DDDY

(Acinetobacter
bereziniae) 		no annotation 4 GLY A 354
THR A 275
GLN A 322
THR A 342
 None
 0.91A 5h5fA-5y4kA:
undetectable		 5h5fA-5y4kA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 4 GLY A 615
PRO A 609
THR A 619
THR A 613
 None
 1.27A 5h5fA-6azpA:
undetectable		 5h5fA-6azpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dgi D-ALANINE--D-ALANINE
LIGASE

(Vibrio cholerae) 		no annotation 4 GLY A  84
PRO A 108
THR A  89
GLN A  93
 ACT  A 402 ( 4.1A)
GOL  A 401 (-4.6A)
None
None
 1.24A 5h5fA-6dgiA:
undetectable		 5h5fA-6dgiA:
undetectable