SIMILAR PATTERNS OF AMINO ACIDS FOR 5H4D_H_BBIH405

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9d RIK1-ASSOCIATED
FACTOR 1

(Schizosaccharomyces
pombe) 		no annotation 4 ARG B 469
GLU B 444
PHE B 446
VAL B 480
 None
None
None
CL  B 705 (-4.5A)
 1.35A 5h4dH-4o9dB:
0.0		 5h4dH-4o9dB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		4 ARG A 169
GLU A 705
PHE A 707
VAL A 151
 None
 1.41A 5h4dH-5d0fA:
0.2		 5h4dH-5d0fA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjd COLLAGEN TYPE IV
ALPHA-3-BINDING
PROTEIN

(Homo sapiens) 		PF01852
(START) 		4 ARG B 442
GLU B 446
PHE B 579
VAL B 525
 PGE  B 604 ( 3.5A)
PGE  B 604 ( 3.4A)
PGE  B 604 (-2.7A)
PGE  B 604 ( 4.6A)
 1.34A 5h4dH-5jjdB:
0.0		 5h4dH-5jjdB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfp EXOCYST COMPLEX
COMPONENT SEC6

(Saccharomyces
cerevisiae) 		no annotation 4 ARG C 502
GLU C 438
PHE C 442
VAL C 592
 None
 1.05A 5h4dH-5yfpC:
0.0		 5h4dH-5yfpC:
13.85