SIMILAR PATTERNS OF AMINO ACIDS FOR 5H4D_A_BBIA403_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy6 CARBAPENEM-HYDROLYSI
NG BETA-LACTAMASE
SME-1

(Serratia
marcescens) 		PF13354
(Beta-lactamase2) 		4 PHE A 141
ARG A 141
GLU A 140
GLU A  98
 None
 1.40A 5h4dA-1dy6A:
undetectable		 5h4dA-1dy6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF07859
(Abhydrolase_3) 		4 ARG A 171
GLU A 170
GLU A 126
VAL A 125
 None
 1.29A 5h4dA-1evqA:
undetectable		 5h4dA-1evqA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzq ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3

(Mus musculus) 		PF00025
(Arf) 		4 ARG A  75
GLU A 113
PHE A  82
GLU A 106
 None
 1.29A 5h4dA-1fzqA:
4.8		 5h4dA-1fzqA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g29 MALTOSE TRANSPORT
PROTEIN MALK

(Thermococcus
litoralis) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 PHE 1 355
PHE 1 339
GLU 1 315
VAL 1 314
 None
 1.21A 5h4dA-1g291:
undetectable		 5h4dA-1g291:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4e CASPASE-8

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 PHE B2476
PHE B2356
GLU B2445
VAL B2446
 None
 1.25A 5h4dA-1i4eB:
3.2		 5h4dA-1i4eB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi4 HYPOTHETICAL PROTEIN
YHBO

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		4 GLU A  57
PHE A 107
GLU A  81
VAL A  82
 None
 1.24A 5h4dA-1oi4A:
5.6		 5h4dA-1oi4A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1l CHORISMATE SYNTHASE

(Aquifex
aeolicus) 		PF01264
(Chorismate_synt) 		4 PHE A 181
ARG A 317
GLU A 171
VAL A 172
 None
 1.38A 5h4dA-1q1lA:
undetectable		 5h4dA-1q1lA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1l CHORISMATE SYNTHASE

(Aquifex
aeolicus) 		PF01264
(Chorismate_synt) 		4 PHE A 181
ARG A 317
PHE A 163
VAL A 172
 None
 1.30A 5h4dA-1q1lA:
undetectable		 5h4dA-1q1lA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9l TRANSCRIPTION
ELONGATION PROTEIN
NUSA

(Escherichia
coli) 		no annotation 4 PHE A 369
GLU A 376
GLU A 383
VAL A 387
 None
 1.41A 5h4dA-1u9lA:
undetectable		 5h4dA-1u9lA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyp BETA-FRUCTOSIDASE

(Thermotoga
maritima) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 PHE A 239
GLU A 391
PHE A 393
VAL A 295
 None
 1.24A 5h4dA-1uypA:
undetectable		 5h4dA-1uypA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5) 		4 GLU 1 305
PHE 1 335
GLU 1 318
VAL 1 319
 None
 1.41A 5h4dA-1wao1:
undetectable		 5h4dA-1wao1:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF01717
(Meth_synt_2) 		4 PHE A  66
GLU A 347
GLU A  55
VAL A  56
 None
 1.05A 5h4dA-1ypxA:
undetectable		 5h4dA-1ypxA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgy CARBOXYSOME SHELL
POLYPEPTIDE

(Halothiobacillus
neapolitanus) 		PF08936
(CsoSCA) 		4 ARG A 496
PHE A  73
GLU A 410
VAL A 411
 None
 1.31A 5h4dA-2fgyA:
undetectable		 5h4dA-2fgyA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hek HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF01966
(HD) 		4 PHE A 172
ARG A 168
GLU A  53
VAL A  13
 None
 1.39A 5h4dA-2hekA:
undetectable		 5h4dA-2hekA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 GLU X 253
PHE X 252
GLU X 260
VAL X 259
 None
 1.36A 5h4dA-2iv2X:
5.4		 5h4dA-2iv2X:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l69 ROSSMANN 2X3 FOLD
PROTEIN

(synthetic
construct) 		no annotation 4 ARG A 105
GLU A 103
GLU A 123
VAL A 124
 None
 1.40A 5h4dA-2l69A:
2.5		 5h4dA-2l69A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l82 DESIGNED PROTEIN
OR32

(synthetic
construct) 		no annotation 4 ARG A 147
PHE A 107
GLU A 140
VAL A 135
 None
 1.27A 5h4dA-2l82A:
2.8		 5h4dA-2l82A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A  65
GLU A 319
GLU A 335
VAL A 334
 None
 1.34A 5h4dA-2og9A:
undetectable		 5h4dA-2og9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I

(Schizosaccharomyces
pombe) 		no annotation 4 PHE G 292
ARG G 290
PHE G 264
VAL G 235
 None
AMP  G 401 (-4.4A)
None
None
 1.20A 5h4dA-2ooxG:
undetectable		 5h4dA-2ooxG:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prr ALKYLHYDROPEROXIDASE
AHPD CORE:
UNCHARACTERIZED
PEROXIDASE-RELATED
PROTEIN

(Cupriavidus
pinatubonensis) 		PF02627
(CMD) 		4 PHE A  55
PHE A 167
GLU A  74
VAL A  77
 None
 1.27A 5h4dA-2prrA:
undetectable		 5h4dA-2prrA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Aromatoleum
aromaticum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A 193
GLU A 325
GLU A 152
VAL A 156
 None
 1.25A 5h4dA-2qdeA:
undetectable		 5h4dA-2qdeA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6j RNA HELICASE

(Kokobera virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		4 ARG A 273
PHE A 206
GLU A 101
VAL A  43
 None
 1.20A 5h4dA-2v6jA:
3.2		 5h4dA-2v6jA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wte CSA3

(Sulfolobus
solfataricus) 		no annotation 4 ARG A  43
GLU A  47
GLU A  65
VAL A  34
 None
 1.26A 5h4dA-2wteA:
2.8		 5h4dA-2wteA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wv0 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR YVOA

(Bacillus
subtilis) 		PF00392
(GntR)
PF07702
(UTRA) 		4 ARG A 211
GLU A 222
PHE A 221
GLU A  91
 None
 1.40A 5h4dA-2wv0A:
undetectable		 5h4dA-2wv0A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy4 SINGLE DOMAIN
HAEMOGLOBIN

(Campylobacter
jejuni) 		PF00042
(Globin) 		4 PHE A  27
PHE A  42
GLU A 134
VAL A  89
 None
HEM  A 150 ( 3.5A)
None
HEM  A 150 (-3.8A)
 1.23A 5h4dA-2wy4A:
undetectable		 5h4dA-2wy4A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 PHE A 403
GLU A 451
PHE A 464
GLU A 418
 None
 1.28A 5h4dA-2x05A:
undetectable		 5h4dA-2x05A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9o 15,16-DIHYDROBILIVER
DIN-FERREDOXIN
OXIDOREDUCTASE

(Synechococcus
sp. WH 8020) 		PF05996
(Fe_bilin_red) 		4 PHE A 229
ARG A  53
PHE A 211
VAL A  65
 None
None
BLA  A1234 (-4.8A)
BLA  A1234 (-4.5A)
 1.10A 5h4dA-2x9oA:
undetectable		 5h4dA-2x9oA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb5 PUTATIVE FUSIDIC
ACID RESISTANCE
PROTEIN

(Staphylococcus
aureus) 		PF07299
(EF-G-binding_N)
PF16571
(FBP_C) 		4 PHE A 139
GLU A  85
GLU A   5
VAL A   6
 None
 1.38A 5h4dA-2yb5A:
undetectable		 5h4dA-2yb5A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B

(Sulfolobus
shibatae) 		PF02518
(HATPase_c)
PF09239
(Topo-VIb_trans) 		4 GLU B 439
PHE B 350
GLU B 434
VAL B 433
 None
 1.24A 5h4dA-2zbkB:
undetectable		 5h4dA-2zbkB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acz METHIONINE
GAMMA-LYASE

(Entamoeba
histolytica) 		PF01053
(Cys_Met_Meta_PP) 		4 ARG A 173
GLU A 172
GLU A 135
VAL A 134
 None
 1.32A 5h4dA-3aczA:
2.7		 5h4dA-3aczA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7o ENDO-1,4-BETA-XYLANA
SE

(Bacillus
subtilis) 		PF03422
(CBM_6)
PF04616
(Glyco_hydro_43) 		4 PHE A 468
PHE A 410
GLU A 359
VAL A 358
 None
None
CA  A 488 (-3.4A)
None
 1.03A 5h4dA-3c7oA:
undetectable		 5h4dA-3c7oA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 PHE A 302
ARG A 301
GLU A 343
GLU A 394
 None
 1.02A 5h4dA-3e7gA:
undetectable		 5h4dA-3e7gA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 PHE A 302
ARG A 301
GLU A 394
VAL A 395
 None
 1.39A 5h4dA-3e7gA:
undetectable		 5h4dA-3e7gA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9t NA/CA EXCHANGE
PROTEIN

(Drosophila
melanogaster) 		PF03160
(Calx-beta) 		4 ARG A 528
PHE A 446
GLU A 477
VAL A 476
 None
 1.13A 5h4dA-3e9tA:
undetectable		 5h4dA-3e9tA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4f (+)-DELTA-CADINENE
SYNTHASE ISOZYME XC1

(Gossypium
arboreum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ARG A 528
GLU A 529
GLU A 492
VAL A 491
 None
 1.35A 5h4dA-3g4fA:
undetectable		 5h4dA-3g4fA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		4 PHE A  30
ARG A  28
GLU A 115
GLU A   2
 None
 1.38A 5h4dA-3g5sA:
1.7		 5h4dA-3g5sA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 PHE A 783
GLU A 721
PHE A 720
VAL A 696
 None
 1.26A 5h4dA-3h0gA:
undetectable		 5h4dA-3h0gA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE

(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 ARG A 207
GLU A  41
GLU A  15
VAL A  18
 U2F  A 547 (-4.4A)
None
U2F  A 547 ( 4.9A)
None
 1.38A 5h4dA-3h4iA:
4.7		 5h4dA-3h4iA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Homo sapiens) 		PF00149
(Metallophos)
PF08321
(PPP5) 		4 GLU A 305
PHE A 335
GLU A 318
VAL A 319
 None
 1.36A 5h4dA-3h68A:
undetectable		 5h4dA-3h68A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il3 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Haemophilus
influenzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ARG A 217
GLU A 218
GLU A 224
VAL A 223
 None
 1.17A 5h4dA-3il3A:
undetectable		 5h4dA-3il3A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irz URO-ADHERENCE FACTOR
A

(Staphylococcus
saprophyticus) 		PF17210
(SdrD_B) 		4 PHE A 492
PHE A 506
GLU A 533
VAL A 530
 None
 1.39A 5h4dA-3irzA:
undetectable		 5h4dA-3irzA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		4 GLU A 191
PHE A 329
GLU A  10
VAL A  11
 None
 1.24A 5h4dA-3kl9A:
undetectable		 5h4dA-3kl9A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgg ADENOSINE DEAMINASE
CECR1

(Homo sapiens) 		PF00962
(A_deaminase)
PF08451
(A_deaminase_N) 		4 PHE A  60
GLU A  68
PHE A  73
GLU A 208
 None
 1.03A 5h4dA-3lggA:
undetectable		 5h4dA-3lggA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6i L-ARABINITOL
4-DEHYDROGENASE

(Neurospora
crassa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ARG A 295
GLU A 238
GLU A 252
VAL A 245
 None
 1.35A 5h4dA-3m6iA:
6.0		 5h4dA-3m6iA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp ELONGATION FACTOR TU
2, ELONGATION FACTOR
TS

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 GLU A 178
PHE A 179
GLU A 193
VAL A 190
 None
 1.18A 5h4dA-3mmpA:
undetectable		 5h4dA-3mmpA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN

(Triatoma virus) 		PF00073
(Rhv)
PF08762
(CRPV_capsid) 		4 PHE A  20
ARG A   9
GLU C 175
VAL C 168
 None
 1.23A 5h4dA-3napA:
undetectable		 5h4dA-3napA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1

(Homo sapiens) 		PF00025
(Arf)
PF01412
(ArfGap) 		4 ARG A 239
GLU A 243
PHE A 212
VAL A 153
 None
 1.36A 5h4dA-3o47A:
4.4		 5h4dA-3o47A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		4 PHE A 253
GLU A 184
GLU A 272
VAL A 273
 None
 1.28A 5h4dA-3q1oA:
undetectable		 5h4dA-3q1oA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Sphaerobacter
thermophilus) 		PF12697
(Abhydrolase_6) 		4 PHE A 199
ARG A 198
GLU A  69
VAL A  68
 None
 1.03A 5h4dA-3r0vA:
2.8		 5h4dA-3r0vA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r31 BETAINE ALDEHYDE
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF00171
(Aldedh) 		4 ARG A 314
GLU A 310
GLU A 274
VAL A 277
 None
 1.15A 5h4dA-3r31A:
3.6		 5h4dA-3r31A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thn EXONUCLEASE,
PUTATIVE

(Thermotoga
maritima) 		PF00149
(Metallophos) 		4 PHE A 119
GLU A 144
PHE A 153
GLU A 197
 None
 1.40A 5h4dA-3thnA:
undetectable		 5h4dA-3thnA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thn EXONUCLEASE,
PUTATIVE

(Thermotoga
maritima) 		PF00149
(Metallophos) 		4 PHE A 137
GLU A 144
PHE A 153
GLU A 197
 None
 1.36A 5h4dA-3thnA:
undetectable		 5h4dA-3thnA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thz DNA MISMATCH REPAIR
PROTEIN MSH2

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 ARG A  55
GLU A  56
PHE A  88
VAL A  78
 None
 1.41A 5h4dA-3thzA:
undetectable		 5h4dA-3thzA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE

(Coxiella
burnetii) 		PF00698
(Acyl_transf_1) 		4 PHE A  34
PHE A 108
GLU A 116
VAL A 115
 None
 1.16A 5h4dA-3tqeA:
undetectable		 5h4dA-3tqeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uem PROTEIN
DISULFIDE-ISOMERASE

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		4 ARG A 452
PHE A 446
GLU A 433
VAL A 432
 None
 1.35A 5h4dA-3uemA:
undetectable		 5h4dA-3uemA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		4 PHE A 370
PHE A  35
GLU A 414
VAL A 415
 None
 1.41A 5h4dA-3vexA:
undetectable		 5h4dA-3vexA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ARG A4286
PHE A4295
GLU A4239
VAL A4137
 None
 0.69A 5h4dA-3vkgA:
undetectable		 5h4dA-3vkgA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		4 PHE A 528
ARG A 553
GLU A 491
PHE A 542
 None
 1.10A 5h4dA-3vr5A:
undetectable		 5h4dA-3vr5A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvj BETA-GLUCANASE

(Ruminiclostridium
thermocellum) 		PF00722
(Glyco_hydro_16) 		4 PHE A 169
PHE A 141
GLU A 107
VAL A 108
 None
 1.18A 5h4dA-3wvjA:
undetectable		 5h4dA-3wvjA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		4 PHE A 812
GLU A 800
GLU A 733
VAL A 791
 None
 1.33A 5h4dA-3zqjA:
undetectable		 5h4dA-3zqjA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Caulobacter sp.
K31) 		PF01532
(Glyco_hydro_47) 		4 PHE A  72
ARG A 125
GLU A  60
GLU A 427
 None
IFL  A 503 ( 4.1A)
None
IFL  A 503 (-2.9A)
 1.41A 5h4dA-4ayrA:
undetectable		 5h4dA-4ayrA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 PHE A 115
PHE A  24
GLU A  52
VAL A  14
 None
 1.42A 5h4dA-4bhtA:
3.9		 5h4dA-4bhtA:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL

(Homo sapiens) 		PF02146
(SIR2) 		4 GLU A 177
PHE A 294
GLU A 323
VAL A 324
 SR7  A1396 (-4.4A)
SR7  A1396 (-3.5A)
None
None
 1.35A 5h4dA-4bn5A:
17.5		 5h4dA-4bn5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL

(Homo sapiens) 		PF02146
(SIR2) 		4 PHE A 157
GLU A 177
PHE A 294
VAL A 324
 SR7  A1396 (-3.7A)
SR7  A1396 (-4.4A)
SR7  A1396 (-3.5A)
None
 1.32A 5h4dA-4bn5A:
17.5		 5h4dA-4bn5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		4 PHE A 749
GLU A 596
GLU A 642
VAL A 643
 None
 1.35A 5h4dA-4bqiA:
2.0		 5h4dA-4bqiA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk9 CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF00150
(Cellulase) 		4 PHE A 348
GLU A  63
PHE A  69
VAL A 172
 None
 1.33A 5h4dA-4fk9A:
undetectable		 5h4dA-4fk9A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igo OS05G0196500 PROTEIN

(Oryza sativa) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 ARG A 148
PHE A 485
GLU A 153
VAL A 467
 None
 1.17A 5h4dA-4igoA:
undetectable		 5h4dA-4igoA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6r ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 PHE A 154
GLU A 247
PHE A 448
GLU A 382
 None
 1.21A 5h4dA-4o6rA:
3.4		 5h4dA-4o6rA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9d RIK1-ASSOCIATED
FACTOR 1

(Schizosaccharomyces
pombe) 		no annotation 4 ARG B 469
GLU B 444
PHE B 446
VAL B 480
 None
None
None
CL  B 705 (-4.5A)
 1.17A 5h4dA-4o9dB:
undetectable		 5h4dA-4o9dB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]

(Rattus
norvegicus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		4 GLU A  26
PHE A 189
GLU A  32
VAL A  31
 None
 1.41A 5h4dA-4ox2A:
undetectable		 5h4dA-4ox2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per ANGIOGENIN
RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF00074
(RnaseA)
PF13516
(LRR_6) 		4 ARG B  66
GLU A 406
GLU A 437
VAL A 438
 None
 1.31A 5h4dA-4perB:
undetectable		 5h4dA-4perB:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 GLU A 169
PHE A 110
GLU A 175
VAL A 176
 None
 0.98A 5h4dA-4pfyA:
undetectable		 5h4dA-4pfyA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1j POLYKETIDE
BIOSYNTHESIS
ENOYL-COA ISOMERASE
PKSI

(Bacillus
subtilis) 		PF00378
(ECH_1) 		4 ARG A 123
GLU A 171
GLU A 184
VAL A 185
 None
 1.26A 5h4dA-4q1jA:
undetectable		 5h4dA-4q1jA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qan HYPOTHETICAL PROTEIN

([Ruminococcus]
gnavus) 		no annotation 4 GLU A 248
PHE A 273
GLU A  37
VAL A  38
 None
 1.02A 5h4dA-4qanA:
undetectable		 5h4dA-4qanA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrm FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
FLAGELLAR MOTOR
SWITCH PROTEIN FLIM

(Thermotoga
maritima) 		PF02154
(FliM)
PF14841
(FliG_M) 		4 PHE A 123
GLU A 147
GLU B 175
VAL B 172
 None
 1.24A 5h4dA-4qrmA:
undetectable		 5h4dA-4qrmA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qus ACETYLTRANSFERASE
YPEA

(Escherichia
coli) 		PF00583
(Acetyltransf_1) 		4 ARG A   4
GLU A   2
GLU A  13
VAL A  55
 None
 1.33A 5h4dA-4qusA:
undetectable		 5h4dA-4qusA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raa PUTATIVE EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF17170
(DUF5128) 		4 PHE A 113
ARG A  68
GLU A 281
VAL A 339
 None
 1.31A 5h4dA-4raaA:
undetectable		 5h4dA-4raaA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN

(Nitratireductor
pacificus) 		PF12838
(Fer4_7)
PF13486
(Dehalogenase) 		4 ARG A 148
GLU A 151
PHE A  57
VAL A 435
 None
 1.31A 5h4dA-4rasA:
undetectable		 5h4dA-4rasA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I,
MODIFICATION SUBUNIT
RESTRICTION
ENDONUCLEASE
ECOP15I, RESTRICTION
SUBUNIT

(Escherichia
coli) 		PF01555
(N6_N4_Mtase)
PF04851
(ResIII) 		4 PHE A 141
ARG A 139
PHE C 176
GLU A 104
 None
 1.42A 5h4dA-4zcfA:
undetectable		 5h4dA-4zcfA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLU A 225
PHE A 181
GLU A 166
VAL A  23
 None
 1.39A 5h4dA-4zohA:
undetectable		 5h4dA-4zohA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fud O-ACETYL-ADP-RIBOSE
DEACETYLASE

(Oceanobacillus
iheyensis) 		PF01661
(Macro) 		4 PHE A 152
PHE A 126
GLU A  72
VAL A  73
 None
 1.32A 5h4dA-5fudA:
undetectable		 5h4dA-5fudA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Mycobacterium
tuberculosis) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		4 PHE A 176
GLU A 212
GLU A  25
VAL A  26
 None
 1.23A 5h4dA-5i67A:
undetectable		 5h4dA-5i67A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 PHE A 800
GLU A 738
PHE A 737
VAL A 713
 None
 1.30A 5h4dA-5iy9A:
undetectable		 5h4dA-5iy9A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iys PHYTOENE SYNTHASE

(Enterococcus
hirae) 		PF00494
(SQS_PSY) 		4 GLU A 225
PHE A 228
GLU A 281
VAL A 282
 None
 1.35A 5h4dA-5iysA:
undetectable		 5h4dA-5iysA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5juf TRANSCRIPTIONAL
REGULATOR

(Streptococcus
thermophilus) 		PF01381
(HTH_3) 		4 ARG A  84
GLU A  80
GLU A 106
VAL A 107
 None
 1.13A 5h4dA-5jufA:
undetectable		 5h4dA-5jufA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kja APOCAROTENOID-15,15'
-OXYGENASE

(Synechocystis
sp. PCC 6803) 		PF03055
(RPE65) 		4 PHE A 303
GLU A 150
PHE A 236
VAL A 112
 None
 1.32A 5h4dA-5kjaA:
undetectable		 5h4dA-5kjaA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2

(Homo sapiens) 		PF00856
(SET)
PF01753
(zf-MYND) 		4 PHE A 184
PHE A  34
GLU A 235
VAL A 236
 6TM  A 502 (-3.4A)
None
None
None
 1.17A 5h4dA-5kjmA:
undetectable		 5h4dA-5kjmA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk5 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Acidaminococcus
sp. BV3L6) 		no annotation 4 GLU A 728
PHE A 590
GLU A 736
VAL A 735
 None
 0.91A 5h4dA-5kk5A:
undetectable		 5h4dA-5kk5A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njo PUTATIVE CUPIN_2
DOMAIN-CONTAINING
ISOMERASE

(Streptomyces
coeruleorubidus) 		no annotation 4 GLU A 105
PHE A 103
GLU A  12
VAL A  23
 None
 1.22A 5h4dA-5njoA:
undetectable		 5h4dA-5njoA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oaf RUVB-LIKE 1

(Homo sapiens) 		no annotation 4 ARG A 118
GLU A 114
GLU A 100
VAL A 101
 None
 1.36A 5h4dA-5oafA:
undetectable		 5h4dA-5oafA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oed GTGE
RAS-RELATED PROTEIN
RAB-32

(Homo sapiens;
Salmonella
enterica) 		no annotation 4 PHE B  88
ARG B  87
GLU B  86
GLU A 198
 None
None
GDP  B 900 (-4.0A)
None
 1.21A 5h4dA-5oedB:
3.2		 5h4dA-5oedB:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile) 		no annotation 4 PHE A 184
GLU A  83
GLU B 138
VAL A 108
 None
 1.16A 5h4dA-5ol2A:
2.5		 5h4dA-5ol2A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf8 POTENTIAL
ADP-RIBOSYLATION
FACTOR

(Candida
albicans) 		PF00025
(Arf) 		4 ARG A  75
GLU A 113
PHE A  82
VAL A  23
 None
 1.15A 5h4dA-5uf8A:
4.6		 5h4dA-5uf8A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6y CHORISMATE MUTASE

(Physcomitrella
patens) 		no annotation 4 PHE A 114
GLU A 120
PHE A 145
VAL A 205
 None
 1.42A 5h4dA-5w6yA:
undetectable		 5h4dA-5w6yA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrt SOLUBLE INORGANIC
PYROPHOSPHATASE

(Toxoplasma
gondii) 		no annotation 4 PHE A 278
ARG A 261
GLU A 250
VAL A 246
 None
 1.28A 5h4dA-5wrtA:
undetectable		 5h4dA-5wrtA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
vivax) 		no annotation 4 GLU A 258
PHE A 249
GLU A  74
VAL A  96
 None
 1.36A 5h4dA-5xmrA:
undetectable		 5h4dA-5xmrA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ya1 AUTOINDUCER-2 KINASE

(Escherichia
coli) 		no annotation 4 ARG A  25
PHE A  29
GLU A 454
VAL A 452
 None
None
HEZ  A 703 (-4.3A)
None
 1.26A 5h4dA-5ya1A:
undetectable		 5h4dA-5ya1A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfp EXOCYST COMPLEX
COMPONENT SEC6

(Saccharomyces
cerevisiae) 		no annotation 4 ARG C 502
GLU C 438
PHE C 442
VAL C 592
 None
 1.37A 5h4dA-5yfpC:
undetectable		 5h4dA-5yfpC:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fae ADP-RIBOSYLATION
FACTOR 1

(Homo sapiens) 		no annotation 4 GLU B 113
PHE B  82
GLU B 106
VAL B  23
 None
 1.16A 5h4dA-6faeB:
4.7		 5h4dA-6faeB:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gup -

(-) 		no annotation 4 PHE A 264
PHE A 281
GLU A 169
VAL A 288
 None
 1.24A 5h4dA-6gupA:
undetectable		 5h4dA-6gupA:
undetectable