SIMILAR PATTERNS OF AMINO ACIDS FOR 5H2U_D_1N1D504

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.55A 5h2uD-1k9aA:
30.2		 5h2uD-1k9aA:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  78
VAL A  86
ALA A  99
ILE A 145
GLY A 153
LEU A 201
 ATP  A 535 (-3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
5EA  A1001 ( 3.7A)
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
 0.49A 5h2uD-1s9iA:
17.5		 5h2uD-1s9iA:
27.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU X  17
VAL X  25
ALA X  37
ILE X  80
GLY X  88
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.62A 5h2uD-2dq7X:
31.6		 5h2uD-2dq7X:
49.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
VAL A 281
ALA A 293
ILE A 336
THR A 338
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.57A 5h2uD-2h8hA:
36.4		 5h2uD-2h8hA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
ALA A 293
ILE A 336
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.53A 5h2uD-2hckA:
33.8		 5h2uD-2hckA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
ALA A 293
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.59A 5h2uD-2hckA:
33.8		 5h2uD-2hckA:
29.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
VAL A 259
ALA A 271
ILE A 314
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.42A 5h2uD-2hk5A:
24.7		 5h2uD-2hk5A:
45.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
ALA A 269
ILE A 313
THR A 315
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.7A)
 0.54A 5h2uD-2hz0A:
31.9		 5h2uD-2hz0A:
42.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
VAL A 256
ALA A 269
ILE A 313
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.8A)
None
GIN  A 600 (-4.7A)
 0.56A 5h2uD-2hz0A:
31.9		 5h2uD-2hz0A:
42.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 VAL A 436
ALA A 452
ILE A 497
LEU A 501
GLY A 505
LEU A 553
GLY A 563
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
None
4ST  A1687 (-4.3A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
None
 0.82A 5h2uD-2j0jA:
30.1		 5h2uD-2j0jA:
18.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 436
ALA A 452
ILE A 497
LEU A 501
GLY A 505
LEU A 553
GLY A 563
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
None
BII  A1687 (-4.4A)
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
BII  A1687 ( 3.9A)
 0.77A 5h2uD-2jkmA:
29.7		 5h2uD-2jkmA:
35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 588
ALA A 614
THR A 663
GLY A 669
LEU A 785
GLY A 795
 None
 0.64A 5h2uD-2ogvA:
22.4		 5h2uD-2ogvA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 588
VAL A 596
ALA A 614
GLY A 669
LEU A 785
GLY A 795
 None
 0.51A 5h2uD-2ogvA:
22.4		 5h2uD-2ogvA:
35.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 LEU A  25
VAL A  33
ALA A  46
LEU A 105
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
 0.50A 5h2uD-2phkA:
22.7		 5h2uD-2phkA:
25.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 487
VAL A 495
ALA A 515
LYS A 517
GLY A 570
LEU A 633
 None
 0.67A 5h2uD-2psqA:
29.4		 5h2uD-2psqA:
32.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
LEU A 245
THR A 265
GLY A 271
LEU A 328
ASP A 339
 ADE  A 488 (-3.2A)
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.58A 5h2uD-2qluA:
24.7		 5h2uD-2qluA:
25.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 724
VAL A 732
ALA A 749
THR A 796
LEU A 798
GLY A 802
LEU A 850
ASP A 861
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.5A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.64A 5h2uD-2r4bA:
32.4		 5h2uD-2r4bA:
31.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 226
VAL A 234
ALA A 247
ILE A 299
LEU A 303
GLY A 307
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 ( 4.9A)
XK9  A1511 (-4.1A)
XK9  A1511 ( 3.7A)
 0.66A 5h2uD-2xk9A:
21.2		 5h2uD-2xk9A:
29.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 226
VAL A 234
ALA A 247
LEU A 303
GLY A 307
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.1A)
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 0.59A 5h2uD-2xk9A:
21.2		 5h2uD-2xk9A:
29.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 635
ALA A 651
ILE A 697
THR A 699
GLY A 705
LEU A 753
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
 0.49A 5h2uD-2xyuA:
26.8		 5h2uD-2xyuA:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1002
VAL A1010
ALA A1028
LYS A1030
LEU A1078
GLY A1082
GLY A1149
 S91  A   1 ( 4.1A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.2A)
S91  A   1 (-4.7A)
S91  A   1 (-3.3A)
None
 0.51A 5h2uD-2z8cA:
28.7		 5h2uD-2z8cA:
36.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1002
VAL A1010
LYS A1030
LEU A1078
GLY A1082
GLY A1149
ASP A1150
 S91  A   1 ( 4.1A)
S91  A   1 ( 4.9A)
S91  A   1 ( 4.2A)
S91  A   1 (-4.7A)
S91  A   1 (-3.3A)
None
None
 0.74A 5h2uD-2z8cA:
28.7		 5h2uD-2z8cA:
36.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 253
VAL A 261
ALA A 273
ILE A 317
GLY A 325
LEU A 374
 None
 0.43A 5h2uD-2zv7A:
27.3		 5h2uD-2zv7A:
45.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 253
VAL A 261
ALA A 273
THR A 319
GLY A 325
LEU A 374
 None
 0.45A 5h2uD-2zv7A:
27.3		 5h2uD-2zv7A:
45.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.55A 5h2uD-3d7uA:
24.6		 5h2uD-3d7uA:
43.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  59
VAL A  67
ALA A  80
ILE A 127
LEU A 131
LEU A 186
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.4A)
None
STU  A   1 (-4.6A)
STU  A   1 (-4.4A)
 0.64A 5h2uD-3fmeA:
16.7		 5h2uD-3fmeA:
26.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 455
ILE A 500
LEU A 504
GLY A 508
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.05A 5h2uD-3fzpA:
29.3		 5h2uD-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 431
ALA A 455
LEU A 504
GLY A 508
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.06A 5h2uD-3fzpA:
29.3		 5h2uD-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 431
VAL A 439
ALA A 455
LEU A 504
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.01A 5h2uD-3fzpA:
29.3		 5h2uD-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 649
ALA A 665
THR A 713
GLY A 719
LEU A 767
ASP A 778
 None
None
None
GOL  A 403 (-3.4A)
None
None
 0.64A 5h2uD-3kulA:
30.5		 5h2uD-3kulA:
34.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 LEU A 680
VAL A 689
ALA A 700
ILE A 743
LEU A 747
LEU A 804
 ADP  A2101 ( 4.1A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
None
None
ADP  A2101 (-4.4A)
 0.58A 5h2uD-3lj0A:
23.2		 5h2uD-3lj0A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 ALA A 229
LEU A 259
THR A 279
GLY A 285
LEU A 339
ASP A 350
 LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.61A 5h2uD-3mdyA:
24.8		 5h2uD-3mdyA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 192
VAL A 200
ALA A 213
LEU A 265
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.9A)
None
AMP  A 577 (-4.8A)
 0.50A 5h2uD-3nyoA:
18.3		 5h2uD-3nyoA:
18.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 363
ALA A 373
LEU A 406
ILE A 419
THR A 421
GLY A 485
 SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
None
 0.66A 5h2uD-3omvA:
27.2		 5h2uD-3omvA:
32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 726
VAL A 734
ALA A 751
THR A 798
LEU A 800
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.46A 5h2uD-3pp0A:
31.1		 5h2uD-3pp0A:
31.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 VAL A 565
ALA A 576
ILE A 623
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.58A 5h2uD-3ppzA:
29.2		 5h2uD-3ppzA:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 VAL A 565
ALA A 576
THR A 625
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.56A 5h2uD-3ppzA:
29.2		 5h2uD-3ppzA:
30.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 217
LEU A 247
THR A 267
GLY A 273
LEU A 329
ASP A 340
 TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
None
 0.54A 5h2uD-3q4tA:
25.1		 5h2uD-3q4tA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL B 603
ALA B 616
ILE B 884
LEU B 888
GLY B 952
ASP B 953
 None
 0.66A 5h2uD-3qd2B:
21.8		 5h2uD-3qd2B:
25.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 423
VAL A 431
ALA A 443
ILE A 487
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-3.6A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.52A 5h2uD-3sxsA:
32.2		 5h2uD-3sxsA:
43.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		8 LEU A 295
VAL A 303
ALA A 315
LEU A 347
GLY A 369
LEU A 423
GLY A 433
ASP A 434
 None
 0.60A 5h2uD-3ulzA:
23.1		 5h2uD-3ulzA:
26.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 544
VAL A 552
ALA A 570
GLY A 623
LEU A 686
GLY A 696
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
0F4  A 902 (-3.3A)
 0.52A 5h2uD-3v5qA:
24.6		 5h2uD-3v5qA:
36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  75
VAL A  83
ALA A  96
ILE A 142
GLY A 150
LEU A 198
ASP A 209
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
 0.62A 5h2uD-3wigA:
26.0		 5h2uD-3wigA:
29.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A1951
VAL A1959
ALA A1978
LEU A2010
ILE A2024
LEU A2028
GLY A2032
LEU A2086
GLY A2101
 VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 (-4.8A)
None
VGH  A3000 ( 4.8A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
VGH  A3000 (-3.5A)
 0.64A 5h2uD-3zbfA:
25.2		 5h2uD-3zbfA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 633
ALA A 649
ILE A 695
GLY A 703
LEU A 751
ASP A 762
 None
 0.64A 5h2uD-3zfxA:
31.1		 5h2uD-3zfxA:
38.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 633
ALA A 649
THR A 697
GLY A 703
LEU A 751
ASP A 762
 None
 0.63A 5h2uD-3zfxA:
31.1		 5h2uD-3zfxA:
38.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  83
VAL A  91
ALA A 104
LEU A 138
GLY A 160
LEU A 207
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
None
VX6  A 500 (-3.3A)
VX6  A 500 (-4.6A)
 0.64A 5h2uD-4af3A:
20.1		 5h2uD-4af3A:
26.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 560
VAL A 568
ALA A 586
GLY A 639
LEU A 699
GLY A 709
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
LTI  A1839 (-3.4A)
 0.59A 5h2uD-4at3A:
30.7		 5h2uD-4at3A:
36.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 VAL A 575
ALA A 588
ILE A 634
LEU A 638
GLY A 642
LEU A 690
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.51A 5h2uD-4e93A:
26.2		 5h2uD-4e93A:
33.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 VAL A 575
ALA A 588
LEU A 638
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.60A 5h2uD-4e93A:
26.2		 5h2uD-4e93A:
33.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 515
VAL A 523
ALA A 541
GLY A 594
LEU A 656
GLY A 666
 None
 0.56A 5h2uD-4f0iA:
29.2		 5h2uD-4f0iA:
33.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 377
VAL A 385
ALA A 400
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.60A 5h2uD-4f4pA:
29.4		 5h2uD-4f4pA:
38.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A1122
VAL A1130
ALA A1148
ILE A1194
LEU A1198
GLY A1202
LEU A1256
GLY A1269
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.8A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 (-4.5A)
 0.55A 5h2uD-4fodA:
23.4		 5h2uD-4fodA:
34.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A 429
ILE A 469
LEU A 473
GLY A 477
LEU A 524
ASP A 536
 0WB  A 701 (-3.3A)
0WB  A 701 (-3.9A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.51A 5h2uD-4g3fA:
23.6		 5h2uD-4g3fA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL A 416
ALA A 429
ILE A 469
LEU A 473
GLY A 477
LEU A 524
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.9A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
 0.51A 5h2uD-4g3fA:
23.6		 5h2uD-4g3fA:
24.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 855
VAL A 863
ALA A 880
GLY A 935
LEU A 983
GLY A 993
 IZA  A2001 (-3.7A)
None
IZA  A2001 (-3.4A)
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
None
 0.62A 5h2uD-4gl9A:
27.0		 5h2uD-4gl9A:
33.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		8 LEU A 132
VAL A 140
ALA A 156
THR A 205
GLY A 211
LEU A 259
GLY A 269
ASP A 270
 None
 0.65A 5h2uD-4hzsA:
31.7		 5h2uD-4hzsA:
34.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		8 LEU A 132
VAL A 140
ALA A 156
THR A 205
LEU A 207
GLY A 211
LEU A 259
ASP A 270
 None
 0.76A 5h2uD-4hzsA:
31.7		 5h2uD-4hzsA:
34.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 132
VAL A 140
ALA A 156
THR A 205
LEU A 207
GLY A 211
LEU A 259
GLY A 269
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
None
 0.81A 5h2uD-4id7A:
25.9		 5h2uD-4id7A:
40.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
ALA A 293
GLY A 344
LEU A 393
ASP A 404
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
 0.45A 5h2uD-4k11A:
36.2		 5h2uD-4k11A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
ALA A 293
ILE A 336
GLY A 344
ASP A 404
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 (-4.4A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-3.1A)
 0.57A 5h2uD-4k11A:
36.2		 5h2uD-4k11A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
ALA A 293
ILE A 336
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.45A 5h2uD-4lggA:
29.2		 5h2uD-4lggA:
52.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL A  36
ALA A  49
LEU A  74
THR A  95
GLY A 101
LEU A 150
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
None
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
 0.55A 5h2uD-4m69A:
22.3		 5h2uD-4m69A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL A  36
LEU A  74
THR A  95
GLY A 101
LEU A 150
ASP A 161
 ANP  A 401 (-4.5A)
None
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
MG  A 403 ( 3.1A)
 0.58A 5h2uD-4m69A:
22.3		 5h2uD-4m69A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  78
VAL A  86
ALA A  99
LEU A 148
GLY A 151
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
 0.56A 5h2uD-4mvfA:
19.3		 5h2uD-4mvfA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  46
VAL A  54
ALA A  67
THR A 123
LEU A 125
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.59A 5h2uD-4o38A:
18.9		 5h2uD-4o38A:
25.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 LEU A  14
VAL A  22
ALA A  35
ILE A  79
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.43A 5h2uD-4ueuA:
30.5		 5h2uD-4ueuA:
52.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 LEU A  14
VAL A  22
ALA A  35
THR A  81
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.52A 5h2uD-4ueuA:
30.5		 5h2uD-4ueuA:
52.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  40
VAL A  48
ALA A  61
ILE A 106
GLY A 114
LEU A 162
 6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 (-3.5A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
 0.57A 5h2uD-4usfA:
17.7		 5h2uD-4usfA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  52
VAL A  60
ALA A  72
ILE A 124
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.56A 5h2uD-4wsqA:
23.8		 5h2uD-4wsqA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 LEU B 267
VAL B 275
ALA B 288
ILE B 332
GLY B 340
LEU B 389
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.38A 5h2uD-4xeyB:
25.5		 5h2uD-4xeyB:
29.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 LEU B 267
VAL B 275
ALA B 288
THR B 334
GLY B 340
LEU B 389
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.44A 5h2uD-4xeyB:
25.5		 5h2uD-4xeyB:
29.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 408
VAL A 416
ALA A 428
LYS A 430
ILE A 472
LEU A 528
ASP A 539
 None
 0.65A 5h2uD-4xi2A:
34.0		 5h2uD-4xi2A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 408
VAL A 416
ALA A 428
LYS A 430
THR A 474
LEU A 528
ASP A 539
 None
 0.79A 5h2uD-4xi2A:
34.0		 5h2uD-4xi2A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 LEU A 408
VAL A 416
ALA A 428
ILE A 472
GLY A 480
LEU A 528
ASP A 539
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 (-3.7A)
 0.61A 5h2uD-4y93A:
34.9		 5h2uD-4y93A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		6 LEU A 408
VAL A 416
ALA A 428
THR A 474
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.54A 5h2uD-4y93A:
34.9		 5h2uD-4y93A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 LEU A 577
VAL A 586
ALA A 597
ILE A 640
LEU A 644
LEU A 695
 None
 0.61A 5h2uD-4z7gA:
20.1		 5h2uD-4z7gA:
23.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
ALA A 625
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.61A 5h2uD-5grnA:
24.4		 5h2uD-5grnA:
39.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
VAL A 607
ALA A 625
ILE A 672
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.9A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.61A 5h2uD-5grnA:
24.4		 5h2uD-5grnA:
39.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  57
VAL A  65
ALA A  77
ILE A 128
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.51A 5h2uD-5i3oA:
17.1		 5h2uD-5i3oA:
27.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 718
VAL A 726
ALA A 743
LEU A 792
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.9A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.33A 5h2uD-5j9zA:
29.0		 5h2uD-5j9zA:
31.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 404
ALA A 417
LEU A 467
GLY A 471
LEU A 518
GLY A 532
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.7A)
 0.60A 5h2uD-5jznA:
22.7		 5h2uD-5jznA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL B 680
ALA B 690
ILE B 737
THR B 739
LEU B 741
ASP B 803
 6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 ( 4.1A)
6U7  B1001 (-4.0A)
6U7  B1001 (-4.6A)
6U7  B1001 (-4.6A)
 0.63A 5h2uD-5kkrB:
22.3		 5h2uD-5kkrB:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 116
VAL A 124
ALA A 137
THR A 187
LEU A 189
GLY A 250
ASP A 251
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
None
None
EDO  A 402 ( 2.9A)
 0.65A 5h2uD-5vcxA:
17.1		 5h2uD-5vcxA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 6 LEU A  24
ALA A  45
LEU A  79
THR A  95
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.59A 5h2uD-5w5jA:
24.3		 5h2uD-5w5jA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 6 LEU A  24
VAL A  32
ALA A  45
ILE A  93
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.59A 5h2uD-5w5jA:
24.3		 5h2uD-5w5jA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 LEU A 891
VAL A 899
ALA A 917
ILE A 961
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
None
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.60A 5h2uD-5wnoA:
31.7		 5h2uD-5wnoA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 LEU A 891
VAL A 899
ALA A 917
LEU A 947
ILE A 961
GLY A 969
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
None
ANP  A1201 ( 4.6A)
 0.62A 5h2uD-5wnoA:
31.7		 5h2uD-5wnoA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 LEU A 891
VAL A 899
ALA A 917
LEU A 947
THR A 963
GLY A 969
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
 0.55A 5h2uD-5wnoA:
31.7		 5h2uD-5wnoA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 LEU A 891
VAL A 899
ALA A 917
THR A 963
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.63A 5h2uD-5wnoA:
31.7		 5h2uD-5wnoA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 VAL A 899
ALA A 917
LEU A 947
THR A 963
GLY A 969
ASP A1028
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
MG  A1202 ( 3.0A)
 0.64A 5h2uD-5wnoA:
31.7		 5h2uD-5wnoA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 6 LEU A  33
VAL A  41
ALA A  54
ILE A  97
GLY A 105
LEU A 153
 ANP  A 501 ( 3.8A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
None
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
 0.45A 5h2uD-6ao5A:
25.1		 5h2uD-6ao5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 6 VAL A  41
ALA A  54
ILE A  97
GLY A 105
LEU A 153
ASP A 164
 ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
None
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
MG  A 502 ( 3.1A)
 0.53A 5h2uD-6ao5A:
25.1		 5h2uD-6ao5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 6 VAL A 226
ALA A 237
GLY A 294
LEU A 347
GLY A 357
ASP A 358
 None
DL1  A 601 (-3.4A)
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
DL1  A 601 ( 4.8A)
DL1  A 601 (-3.1A)
 0.59A 5h2uD-6bfnA:
24.2		 5h2uD-6bfnA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 LEU A 881
VAL A 889
ALA A 906
GLY A 962
LEU A1010
GLY A1020
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
None
 0.57A 5h2uD-6c7yA:
28.0		 5h2uD-6c7yA:
15.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 8 LEU A 197
VAL A 205
ALA A 217
ILE A 262
THR A 264
LEU A 266
LEU A 319
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
 0.72A 5h2uD-6cz4A:
35.3		 5h2uD-6cz4A:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 8 LEU A 197
VAL A 205
ALA A 217
LEU A 248
ILE A 262
THR A 264
LEU A 266
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.4A)
 0.73A 5h2uD-6cz4A:
35.3		 5h2uD-6cz4A:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 8 LEU A 197
VAL A 205
ALA A 217
LEU A 248
THR A 264
LEU A 266
GLY A 270
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.4A)
 0.84A 5h2uD-6cz4A:
35.3		 5h2uD-6cz4A:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 8 LEU A 197
VAL A 205
ALA A 217
THR A 264
LEU A 266
GLY A 270
LEU A 319
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
 0.83A 5h2uD-6cz4A:
35.3		 5h2uD-6cz4A:
93.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 6 LEU A 167
VAL A 175
ALA A 189
ILE A 239
LEU A 243
LEU A 295
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
None
EAQ  A 501 ( 4.9A)
EAQ  A 501 (-4.9A)
 0.54A 5h2uD-6fyoA:
21.3		 5h2uD-6fyoA:
undetectable