SIMILAR PATTERNS OF AMINO ACIDS FOR 5H2U_C_1N1C501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 220
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.52A 5h2uC-1k9aA:
30.1		 5h2uC-1k9aA:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 267
ALA A 288
ILE A 332
THR A 334
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.75A 5h2uC-1opkA:
29.3		 5h2uC-1opkA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 ARG A 162
LEU A 164
ALA A 185
LEU A 226
GLY A 250
LEU A 301
 None
ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.4A)
None
ADP  A 810 (-4.7A)
 1.04A 5h2uC-1q8yA:
21.2		 5h2uC-1q8yA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  99
ILE A 145
GLY A 153
LEU A 201
ASP A 212
 ATP  A 535 (-3.6A)
5EA  A1001 ( 3.7A)
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
MG  A 536 (-3.3A)
 0.56A 5h2uC-1s9iA:
17.8		 5h2uC-1s9iA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  78
ALA A  99
ILE A 145
GLY A 153
LEU A 201
 ATP  A 535 (-3.9A)
ATP  A 535 (-3.6A)
5EA  A1001 ( 3.7A)
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
 0.52A 5h2uC-1s9iA:
17.8		 5h2uC-1s9iA:
27.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA X  37
ILE X  80
THR X  82
GLY X  88
LEU X 137
 STU  X 902 (-3.1A)
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.64A 5h2uC-2dq7X:
31.4		 5h2uC-2dq7X:
49.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU X  17
ALA X  37
ILE X  80
THR X  82
GLY X  88
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
 0.68A 5h2uC-2dq7X:
31.4		 5h2uC-2dq7X:
49.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
ALA A 293
ILE A 336
THR A 338
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.63A 5h2uC-2h8hA:
36.1		 5h2uC-2h8hA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
ALA A 293
LYS A 295
ILE A 336
THR A 338
GLY A 344
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.2A)
 0.77A 5h2uC-2h8hA:
36.1		 5h2uC-2h8hA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
ALA A 293
ILE A 336
GLY A 344
LEU A 393
ASP A 404
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.69A 5h2uC-2hckA:
28.3		 5h2uC-2hckA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
ALA A 293
THR A 338
GLY A 344
LEU A 393
ASP A 404
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.67A 5h2uC-2hckA:
28.3		 5h2uC-2hckA:
29.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 659
LYS A 661
THR A 707
GLY A 713
LEU A 761
 ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.59A 5h2uC-2henA:
26.3		 5h2uC-2henA:
37.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
ALA A 271
ILE A 314
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.49A 5h2uC-2hk5A:
24.5		 5h2uC-2hk5A:
45.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
ALA A 269
ILE A 313
THR A 315
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.7A)
 0.58A 5h2uC-2hz0A:
31.8		 5h2uC-2hz0A:
42.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 ARG A 426
ALA A 452
ILE A 497
GLY A 505
LEU A 553
GLY A 563
 None
4ST  A1687 (-3.3A)
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
None
 0.87A 5h2uC-2j0jA:
30.0		 5h2uC-2j0jA:
18.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
ALA A 271
ILE A 314
THR A 316
GLY A 322
LEU A 371
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.73A 5h2uC-2og8A:
29.9		 5h2uC-2og8A:
45.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 588
ALA A 614
LYS A 616
GLY A 669
LEU A 785
GLY A 795
 None
 0.68A 5h2uC-2ogvA:
27.3		 5h2uC-2ogvA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 588
ALA A 614
THR A 663
GLY A 669
LEU A 785
GLY A 795
 None
 0.70A 5h2uC-2ogvA:
27.3		 5h2uC-2ogvA:
35.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 LEU A 344
ALA A 367
LYS A 369
LEU A 468
ASP A 479
 ANP  A 615 (-4.4A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
 0.59A 5h2uC-2ozoA:
31.6		 5h2uC-2ozoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 ARG X  32
LEU X  34
ALA X  53
ILE X 115
LEU X 179
 None
HMD  X 400 ( 4.3A)
HMD  X 400 (-3.5A)
None
HMD  X 400 (-4.7A)
 0.55A 5h2uC-2pmoX:
5.2		 5h2uC-2pmoX:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
LEU A 245
THR A 265
GLY A 271
LEU A 328
ASP A 339
 ADE  A 488 (-3.2A)
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.62A 5h2uC-2qluA:
24.6		 5h2uC-2qluA:
25.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ALA A 705
ILE A 751
THR A 753
GLY A 759
LEU A 807
 None
 0.61A 5h2uC-2r2pA:
29.4		 5h2uC-2r2pA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 724
ALA A 749
THR A 796
GLY A 802
LEU A 850
ASP A 861
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.69A 5h2uC-2r4bA:
28.0		 5h2uC-2r4bA:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 651
ILE A 697
THR A 699
GLY A 705
LEU A 753
 Q9G  A1898 (-3.2A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
 0.49A 5h2uC-2xyuA:
26.7		 5h2uC-2xyuA:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ARG A1000
LEU A1002
ALA A1028
LYS A1030
GLY A1082
GLY A1149
 None
S91  A   1 ( 4.1A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.2A)
S91  A   1 (-3.3A)
None
 0.44A 5h2uC-2z8cA:
28.6		 5h2uC-2z8cA:
36.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 273
LYS A 275
THR A 319
GLY A 325
LEU A 374
 None
 0.66A 5h2uC-2zv7A:
31.1		 5h2uC-2zv7A:
45.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 253
ALA A 273
ILE A 317
GLY A 325
LEU A 374
 None
 0.53A 5h2uC-2zv7A:
31.1		 5h2uC-2zv7A:
45.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 253
ALA A 273
THR A 319
GLY A 325
LEU A 374
 None
 0.49A 5h2uC-2zv7A:
31.1		 5h2uC-2zv7A:
45.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 220
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.52A 5h2uC-3d7uA:
24.8		 5h2uC-3d7uA:
43.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 455
ILE A 500
GLY A 508
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 (-3.6A)
None
None
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.09A 5h2uC-3fzpA:
29.2		 5h2uC-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 431
ALA A 455
GLY A 508
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.07A 5h2uC-3fzpA:
29.2		 5h2uC-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 431
ALA A 455
LYS A 457
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.05A 5h2uC-3fzpA:
29.2		 5h2uC-3fzpA:
37.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		6 LEU A 338
ALA A 230
LEU A 144
ILE A  90
THR A  86
GLY A 110
 None
 1.19A 5h2uC-3hhdA:
undetectable		 5h2uC-3hhdA:
14.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 696
THR A 768
GLY A 774
LEU A 822
ASP A 833
 ANP  A   1 (-4.4A)
ANP  A   1 ( 4.8A)
ANP  A   1 ( 4.9A)
ANP  A   1 (-4.7A)
MG  A1001 ( 3.1A)
 0.59A 5h2uC-3kexA:
33.2		 5h2uC-3kexA:
30.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		5 ALA A 229
LEU A 259
THR A 279
GLY A 285
LEU A 339
 LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.63A 5h2uC-3mdyA:
24.8		 5h2uC-3mdyA:
28.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 373
LEU A 406
ILE A 419
THR A 421
GLY A 485
 SM5  A   1 (-3.6A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
None
 0.64A 5h2uC-3omvA:
27.1		 5h2uC-3omvA:
32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 726
ALA A 751
THR A 798
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.50A 5h2uC-3pp0A:
31.1		 5h2uC-3pp0A:
31.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 217
LEU A 247
THR A 267
GLY A 273
ASP A 340
 TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
None
 0.56A 5h2uC-3q4tA:
24.9		 5h2uC-3q4tA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 217
LEU A 247
THR A 267
GLY A 273
LEU A 329
 TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
 0.56A 5h2uC-3q4tA:
24.9		 5h2uC-3q4tA:
27.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 423
ALA A 443
LYS A 445
ILE A 487
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.6A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.65A 5h2uC-3sxsA:
32.1		 5h2uC-3sxsA:
43.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 423
ALA A 443
LYS A 445
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.63A 5h2uC-3sxsA:
32.1		 5h2uC-3sxsA:
43.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 LEU A 295
ALA A 315
LEU A 347
GLY A 369
LEU A 423
GLY A 433
ASP A 434
 None
 0.51A 5h2uC-3ulzA:
18.5		 5h2uC-3ulzA:
26.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ARG A 542
LEU A 544
ALA A 570
GLY A 623
LEU A 686
GLY A 696
 None
0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
0F4  A 902 (-3.3A)
 0.56A 5h2uC-3v5qA:
24.6		 5h2uC-3v5qA:
36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  75
ALA A  96
LYS A  98
ILE A 142
GLY A 150
LEU A 198
ASP A 209
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
 0.70A 5h2uC-3wigA:
26.1		 5h2uC-3wigA:
29.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 840
ALA A 866
GLY A 922
LEU A1035
ASP A1046
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.55A 5h2uC-3wzdA:
29.6		 5h2uC-3wzdA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1951
ALA A1978
LEU A2010
ILE A2024
GLY A2032
LEU A2086
GLY A2101
 VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 (-4.8A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
VGH  A3000 (-3.5A)
 0.65A 5h2uC-3zbfA:
29.1		 5h2uC-3zbfA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 649
ILE A 695
THR A 697
GLY A 703
LEU A 751
 None
 0.57A 5h2uC-3zfxA:
30.9		 5h2uC-3zfxA:
38.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 649
LYS A 651
THR A 697
GLY A 703
LEU A 751
 None
 0.68A 5h2uC-3zfxA:
30.9		 5h2uC-3zfxA:
38.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 840
ALA A 866
LYS A 868
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.67A 5h2uC-4agdA:
4.0		 5h2uC-4agdA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ARG A 558
LEU A 560
ALA A 586
GLY A 639
LEU A 699
GLY A 709
 None
LTI  A1839 ( 4.2A)
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
LTI  A1839 (-3.4A)
 0.68A 5h2uC-4at3A:
30.7		 5h2uC-4at3A:
36.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  42
ALA A  63
GLY A 116
LEU A 164
ASP A 175
 XZN  A1317 (-3.6A)
XZN  A1317 (-3.5A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
XZN  A1317 (-3.2A)
 0.60A 5h2uC-4bc6A:
21.3		 5h2uC-4bc6A:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  42
ALA A  63
ILE A 108
GLY A 116
LEU A 164
 XZN  A1317 (-3.6A)
XZN  A1317 (-3.5A)
XZN  A1317 (-4.4A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
 0.66A 5h2uC-4bc6A:
21.3		 5h2uC-4bc6A:
27.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 515
ALA A 541
GLY A 594
LEU A 656
GLY A 666
 None
 0.51A 5h2uC-4f0iA:
23.3		 5h2uC-4f0iA:
33.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 LEU A 377
ALA A 400
LYS A 402
GLY A 454
LEU A 501
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.58A 5h2uC-4fl3A:
33.0		 5h2uC-4fl3A:
21.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1122
ALA A1148
ILE A1194
GLY A1202
LEU A1256
GLY A1269
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 (-4.5A)
 0.50A 5h2uC-4fodA:
23.4		 5h2uC-4fodA:
34.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 855
ALA A 880
GLY A 935
LEU A 983
GLY A 993
 IZA  A2001 (-3.7A)
IZA  A2001 (-3.4A)
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
None
 0.59A 5h2uC-4gl9A:
26.8		 5h2uC-4gl9A:
33.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 LEU A 132
ALA A 156
LYS A 158
THR A 205
GLY A 269
ASP A 270
 None
 0.71A 5h2uC-4hzsA:
23.9		 5h2uC-4hzsA:
34.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		7 LEU A 132
ALA A 156
THR A 205
GLY A 211
LEU A 259
GLY A 269
ASP A 270
 None
 0.59A 5h2uC-4hzsA:
23.9		 5h2uC-4hzsA:
34.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 132
ALA A 156
THR A 205
GLY A 211
LEU A 259
GLY A 269
 1G0  A 401 ( 4.5A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
None
 0.81A 5h2uC-4id7A:
25.8		 5h2uC-4id7A:
40.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
ALA A 293
GLY A 344
LEU A 393
ASP A 404
 0J9  A 601 (-4.0A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
 0.42A 5h2uC-4k11A:
36.0		 5h2uC-4k11A:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  33
ALA A  54
ILE A  97
GLY A 105
LEU A 153
 GOL  A 404 ( 3.6A)
GOL  A 404 ( 3.1A)
None
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
 0.66A 5h2uC-4lg4A:
21.5		 5h2uC-4lg4A:
25.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 273
ALA A 293
ILE A 336
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.57A 5h2uC-4lggA:
29.2		 5h2uC-4lggA:
52.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 273
ALA A 293
LYS A 295
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.61A 5h2uC-4lggA:
29.2		 5h2uC-4lggA:
52.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A  49
LEU A  74
THR A  95
GLY A 101
LEU A 150
ASP A 161
 ANP  A 401 (-3.1A)
None
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
MG  A 403 ( 3.1A)
 0.49A 5h2uC-4m69A:
22.6		 5h2uC-4m69A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA A  49
LYS A  51
LEU A  74
THR A  95
ASP A 161
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
MG  A 403 ( 3.1A)
 0.56A 5h2uC-4m69A:
22.6		 5h2uC-4m69A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ARG A  44
LEU A  46
ALA A  67
GLY A 128
GLU A 132
LEU A 180
 None
SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
 1.02A 5h2uC-4o38A:
18.8		 5h2uC-4o38A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ARG A  44
LEU A  46
ALA A  67
THR A 123
GLY A 128
LEU A 180
 None
SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.66A 5h2uC-4o38A:
18.8		 5h2uC-4o38A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 ARG A 190
LEU A 192
ALA A 213
LEU A 318
ASP A 329
 None
SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.59A 5h2uC-4tnbA:
19.8		 5h2uC-4tnbA:
21.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 ARG A  12
LEU A  14
ALA A  35
ILE A  79
GLY A  87
LEU A 136
 None
ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.64A 5h2uC-4ueuA:
30.3		 5h2uC-4ueuA:
52.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 ARG A  12
LEU A  14
ALA A  35
THR A  81
GLY A  87
LEU A 136
 None
ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.67A 5h2uC-4ueuA:
30.3		 5h2uC-4ueuA:
52.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  40
ALA A  61
ILE A 106
GLY A 114
LEU A 162
 6UI  A 700 ( 4.9A)
6UI  A 700 (-3.3A)
6UI  A 700 (-3.5A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
 0.55A 5h2uC-4usfA:
17.7		 5h2uC-4usfA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  52
ALA A  72
ILE A 124
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.60A 5h2uC-4wsqA:
23.6		 5h2uC-4wsqA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 LEU B 267
ALA B 288
ILE B 332
THR B 334
GLY B 340
LEU B 389
 1N1  B 601 (-3.7A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.52A 5h2uC-4xeyB:
30.8		 5h2uC-4xeyB:
29.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 LEU B 267
ALA B 288
LYS B 290
ILE B 332
THR B 334
GLY B 340
 1N1  B 601 (-3.7A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
 0.61A 5h2uC-4xeyB:
30.8		 5h2uC-4xeyB:
29.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 408
ALA A 428
THR A 474
GLY A 480
LEU A 528
ASP A 539
 None
 0.95A 5h2uC-4xi2A:
30.3		 5h2uC-4xi2A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		6 LEU A 408
ALA A 428
ILE A 472
GLY A 480
LEU A 528
ASP A 539
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 (-3.7A)
 0.65A 5h2uC-4y93A:
35.0		 5h2uC-4y93A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		6 LEU A 408
ALA A 428
THR A 474
GLY A 480
LEU A 528
ASP A 539
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 (-3.7A)
 0.71A 5h2uC-4y93A:
35.0		 5h2uC-4y93A:
24.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 484
ALA A 512
GLY A 567
LEU A 630
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.63A 5h2uC-5a46A:
29.1		 5h2uC-5a46A:
35.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		6 ARG A  97
LEU A  99
ALA A 120
LEU A 154
GLY A 176
LEU A 223
 None
5U5  A 401 (-3.8A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.8A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.68A 5h2uC-5eykA:
22.8		 5h2uC-5eykA:
27.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
ALA A 625
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.65A 5h2uC-5grnA:
24.2		 5h2uC-5grnA:
39.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  57
ALA A  77
ILE A 128
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.54A 5h2uC-5i3oA:
23.0		 5h2uC-5i3oA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ARG A 394
ALA A 417
LYS A 419
GLY A 471
LEU A 518
GLY A 532
 None
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.7A)
 0.84A 5h2uC-5jznA:
22.5		 5h2uC-5jznA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 209
ALA A 228
LEU A 263
GLY A 289
LEU A 338
 None
6UY  A 501 (-3.4A)
None
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
 0.68A 5h2uC-5ko1A:
24.9		 5h2uC-5ko1A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		5 LEU A  18
ALA A  39
LYS A  41
LEU A  73
ILE A  87
 None
 0.66A 5h2uC-5m09A:
21.9		 5h2uC-5m09A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 8 LEU A  24
ALA A  45
LYS A  47
ILE A  93
THR A  95
GLY A 101
GLU A 105
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
None
9WS  A 401 (-4.6A)
 0.72A 5h2uC-5w5jA:
18.4		 5h2uC-5w5jA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 8 LEU A  24
ALA A  45
LYS A  47
LEU A  79
THR A  95
GLY A 101
GLU A 105
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
None
9WS  A 401 (-4.6A)
 0.69A 5h2uC-5w5jA:
18.4		 5h2uC-5w5jA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 LEU A 891
ALA A 917
LEU A 947
ILE A 961
GLY A 969
LEU A1017
ASP A1028
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
None
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
MG  A1202 ( 3.0A)
 0.73A 5h2uC-5wnoA:
31.6		 5h2uC-5wnoA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 LEU A 891
ALA A 917
LEU A 947
THR A 963
GLY A 969
LEU A1017
ASP A1028
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
MG  A1202 ( 3.0A)
 0.64A 5h2uC-5wnoA:
31.6		 5h2uC-5wnoA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 5 ALA A  54
ILE A  97
GLY A 105
LEU A 153
ASP A 164
 ANP  A 501 ( 3.7A)
None
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
MG  A 502 ( 3.1A)
 0.53A 5h2uC-6ao5A:
24.9		 5h2uC-6ao5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 5 LEU A  33
ALA A  54
GLY A 105
LEU A 153
ASP A 164
 ANP  A 501 ( 3.8A)
ANP  A 501 ( 3.7A)
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
MG  A 502 ( 3.1A)
 0.45A 5h2uC-6ao5A:
24.9		 5h2uC-6ao5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 5 ALA A 237
GLY A 294
LEU A 347
GLY A 357
ASP A 358
 DL1  A 601 (-3.4A)
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
DL1  A 601 ( 4.8A)
DL1  A 601 (-3.1A)
 0.57A 5h2uC-6bfnA:
24.1		 5h2uC-6bfnA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 ARG A 879
LEU A 881
ALA A 906
GLY A 962
GLU A 966
LEU A1010
 None
ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.5A)
 0.69A 5h2uC-6c7yA:
28.0		 5h2uC-6c7yA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 ARG A 879
LEU A 881
ALA A 906
GLY A 962
LEU A1010
GLY A1020
 None
ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
None
 0.63A 5h2uC-6c7yA:
28.0		 5h2uC-6c7yA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 ARG A 879
LEU A 881
GLY A 962
LEU A1010
GLY A1020
ASP A1021
 None
ADP  A1201 ( 4.5A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
None
MG  A1203 (-1.8A)
 0.92A 5h2uC-6c7yA:
28.0		 5h2uC-6c7yA:
15.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 ARG A 195
LEU A 197
ALA A 217
LEU A 248
THR A 264
GLY A 329
 None
FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-3.4A)
 1.09A 5h2uC-6cz4A:
35.2		 5h2uC-6cz4A:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 ARG A 195
LEU A 197
ALA A 217
THR A 264
LEU A 319
GLY A 329
 None
FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
 1.07A 5h2uC-6cz4A:
35.2		 5h2uC-6cz4A:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 LEU A 197
ALA A 217
ILE A 262
THR A 264
LEU A 319
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.0A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
 0.74A 5h2uC-6cz4A:
35.2		 5h2uC-6cz4A:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 LEU A 197
ALA A 217
LEU A 248
ILE A 262
THR A 264
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-3.4A)
 0.79A 5h2uC-6cz4A:
35.2		 5h2uC-6cz4A:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 LEU A 197
ALA A 217
LEU A 248
THR A 264
GLY A 270
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.4A)
 0.93A 5h2uC-6cz4A:
35.2		 5h2uC-6cz4A:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 LEU A 197
ALA A 217
THR A 264
GLY A 270
LEU A 319
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
 0.91A 5h2uC-6cz4A:
35.2		 5h2uC-6cz4A:
93.75