SIMILAR PATTERNS OF AMINO ACIDS FOR 5H2U_B_1N1B501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 209
ALA A 220
ILE A 264
THR A 266
GLY A 272
LEU A 321
ASP A 332
 None
 0.76A 5h2uB-1k9aA:
30.3		 5h2uB-1k9aA:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
VAL A 275
ALA A 288
ILE A 332
THR A 334
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.78A 5h2uB-1opkA:
29.5		 5h2uB-1opkA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  78
VAL A  86
ALA A  99
ILE A 145
GLY A 153
LEU A 201
 ATP  A 535 (-3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
5EA  A1001 ( 3.7A)
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
 0.54A 5h2uB-1s9iA:
17.7		 5h2uB-1s9iA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  86
ALA A  99
ILE A 145
GLY A 153
LEU A 201
ASP A 212
 ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
5EA  A1001 ( 3.7A)
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
MG  A 536 (-3.3A)
 0.58A 5h2uB-1s9iA:
17.7		 5h2uB-1s9iA:
27.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 595
VAL A 603
ALA A 621
THR A 670
GLY A 676
LEU A 799
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
 0.73A 5h2uB-1t46A:
25.9		 5h2uB-1t46A:
37.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
ALA A  36
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.81A 5h2uB-1zltA:
16.3		 5h2uB-1zltA:
28.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU X  17
VAL X  25
ALA X  37
GLY X  88
LEU X 137
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.80A 5h2uB-2dq7X:
31.6		 5h2uB-2dq7X:
49.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
VAL X  25
ALA X  37
ILE X  80
THR X  82
GLY X  88
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.73A 5h2uB-2dq7X:
31.6		 5h2uB-2dq7X:
49.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 162
VAL A 170
ALA A 184
ILE A 234
LEU A 238
LEU A 290
ASP A 320
 None
 0.99A 5h2uB-2eu9A:
21.1		 5h2uB-2eu9A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
ALA A  40
ILE A  91
LEU A  95
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 ( 4.9A)
ADP  A 500 (-4.3A)
 0.63A 5h2uB-2f9gA:
16.6		 5h2uB-2f9gA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
GLY A 110
LEU A 158
GLY A 168
ASP A 169
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 (-3.4A)
STU  A 400 ( 4.6A)
None
STU  A 400 (-3.6A)
 0.78A 5h2uB-2gcdA:
25.3		 5h2uB-2gcdA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
VAL A 281
ALA A 293
ILE A 336
THR A 338
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.64A 5h2uB-2h8hA:
36.3		 5h2uB-2h8hA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
VAL A 281
ALA A 293
ILE A 336
THR A 338
GLY A 344
LEU A 393
ASP A 404
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.71A 5h2uB-2hckA:
33.7		 5h2uB-2hckA:
29.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 643
ALA A 659
LYS A 661
ILE A 705
THR A 707
GLY A 713
LEU A 761
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.69A 5h2uB-2henA:
26.5		 5h2uB-2henA:
37.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
VAL A 259
ALA A 271
ILE A 314
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.44A 5h2uB-2hk5A:
24.5		 5h2uB-2hk5A:
45.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 248
VAL A 256
ALA A 269
ILE A 313
THR A 315
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.7A)
 0.66A 5h2uB-2hz0A:
32.0		 5h2uB-2hz0A:
42.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 VAL A 436
ALA A 452
ILE A 497
LEU A 501
GLY A 505
LEU A 553
GLY A 563
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
None
4ST  A1687 (-4.3A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
None
 0.81A 5h2uB-2j0jA:
30.2		 5h2uB-2j0jA:
18.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 436
ALA A 452
ILE A 497
LEU A 501
GLY A 505
LEU A 553
GLY A 563
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
None
BII  A1687 (-4.4A)
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
BII  A1687 ( 3.9A)
 0.78A 5h2uB-2jkmA:
29.8		 5h2uB-2jkmA:
35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 436
ALA A 452
LYS A 454
ILE A 497
LEU A 501
GLY A 563
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
None
BII  A1687 (-4.4A)
BII  A1687 ( 3.9A)
 0.87A 5h2uB-2jkmA:
29.8		 5h2uB-2jkmA:
35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
ALA A 271
ILE A 314
THR A 316
GLY A 322
LEU A 371
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.80A 5h2uB-2og8A:
30.0		 5h2uB-2og8A:
45.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
VAL A 259
ALA A 271
LYS A 273
ILE A 314
THR A 316
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
 0.64A 5h2uB-2og8A:
30.0		 5h2uB-2og8A:
45.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
VAL A 596
ALA A 614
LYS A 616
THR A 663
LEU A 785
GLY A 795
 None
 0.87A 5h2uB-2ogvA:
27.7		 5h2uB-2ogvA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
VAL A 596
ALA A 614
THR A 663
GLY A 669
LEU A 785
GLY A 795
 None
 0.70A 5h2uB-2ogvA:
27.7		 5h2uB-2ogvA:
35.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 LEU A 344
VAL A 352
ALA A 367
LYS A 369
GLY A 420
LEU A 468
ASP A 479
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
 0.83A 5h2uB-2ozoA:
31.9		 5h2uB-2ozoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 LEU A  25
VAL A  33
ALA A  46
LEU A 105
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
 0.60A 5h2uB-2phkA:
22.8		 5h2uB-2phkA:
25.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 487
VAL A 495
ALA A 515
LYS A 517
GLY A 570
LEU A 633
 None
 0.71A 5h2uB-2psqA:
29.6		 5h2uB-2psqA:
32.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
LEU A 245
THR A 265
GLY A 271
LEU A 328
ASP A 339
 ADE  A 488 (-3.2A)
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.58A 5h2uB-2qluA:
24.8		 5h2uB-2qluA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 204
ALA A 215
THR A 265
GLY A 271
LEU A 328
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.73A 5h2uB-2qluA:
24.8		 5h2uB-2qluA:
25.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 635
ALA A 651
ILE A 697
THR A 699
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 0.60A 5h2uB-2qobA:
24.2		 5h2uB-2qobA:
33.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 689
ALA A 705
ILE A 751
THR A 753
GLY A 759
LEU A 807
 None
 0.63A 5h2uB-2r2pA:
29.5		 5h2uB-2r2pA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 724
VAL A 732
ALA A 749
THR A 796
LEU A 798
GLY A 802
LEU A 850
ASP A 861
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.5A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.68A 5h2uB-2r4bA:
32.4		 5h2uB-2r4bA:
31.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  52
VAL A  60
ALA A  73
LEU A 120
LEU A 171
ASP A 185
 DKI  A1338 (-3.8A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
DKI  A1338 (-4.2A)
DKI  A1338 (-4.9A)
DKI  A1338 (-3.8A)
 0.82A 5h2uB-2w4oA:
22.5		 5h2uB-2w4oA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 226
VAL A 234
ALA A 247
ILE A 299
LEU A 303
GLY A 307
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 ( 4.9A)
XK9  A1511 (-4.1A)
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 0.72A 5h2uB-2xk9A:
14.4		 5h2uB-2xk9A:
29.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 635
ALA A 651
ILE A 697
THR A 699
GLY A 705
LEU A 753
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
 0.53A 5h2uB-2xyuA:
26.7		 5h2uB-2xyuA:
38.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  38
ALA A  51
LEU A 109
GLY A 113
LEU A 160
ASP A 171
 None
B49  A1294 (-3.2A)
B49  A1294 ( 4.7A)
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
 0.84A 5h2uB-2y7jA:
8.1		 5h2uB-2y7jA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 313
ALA A 326
ILE A 374
GLY A 382
GLY A 462
ASP A 463
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
None
770  A 901 (-3.4A)
None
770  A 901 (-3.8A)
 0.83A 5h2uB-2z2wA:
23.8		 5h2uB-2z2wA:
27.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1002
VAL A1010
ALA A1028
LYS A1030
GLY A1082
GLY A1149
ASP A1150
 S91  A   1 ( 4.1A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.2A)
S91  A   1 (-3.3A)
None
None
 0.76A 5h2uB-2z8cA:
28.8		 5h2uB-2z8cA:
36.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1002
VAL A1010
ALA A1028
LYS A1030
LEU A1078
GLY A1082
GLY A1149
 S91  A   1 ( 4.1A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.2A)
S91  A   1 (-4.7A)
S91  A   1 (-3.3A)
None
 0.49A 5h2uB-2z8cA:
28.8		 5h2uB-2z8cA:
36.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 253
VAL A 261
ALA A 273
ILE A 317
THR A 319
GLY A 325
LEU A 374
 None
 0.50A 5h2uB-2zv7A:
27.2		 5h2uB-2zv7A:
45.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 261
LYS A 275
ILE A 317
THR A 319
GLY A 325
LEU A 374
 None
 0.84A 5h2uB-2zv7A:
27.2		 5h2uB-2zv7A:
45.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 484
VAL A 492
ALA A 512
GLY A 567
LEU A 630
ASP A 641
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
 0.84A 5h2uB-3c4fA:
29.8		 5h2uB-3c4fA:
41.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 209
ALA A 220
ILE A 264
THR A 266
GLY A 272
LEU A 321
ASP A 332
 None
 0.76A 5h2uB-3d7uA:
24.9		 5h2uB-3d7uA:
43.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		6 LEU A  29
VAL A  37
ALA A  50
GLY A 106
LEU A 153
ASP A 167
 None
 0.78A 5h2uB-3dxnA:
27.2		 5h2uB-3dxnA:
31.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  59
VAL A  67
ALA A  80
ILE A 127
LEU A 131
LEU A 186
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.4A)
None
STU  A   1 (-4.6A)
STU  A   1 (-4.4A)
 0.75A 5h2uB-3fmeA:
16.8		 5h2uB-3fmeA:
26.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 431
VAL A 439
ALA A 455
LEU A 504
GLY A 508
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.08A 5h2uB-3fzpA:
24.1		 5h2uB-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 431
VAL A 439
ALA A 455
LYS A 457
LEU A 504
GLY A 566
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-4.4A)
None
AGS  A 999 ( 3.9A)
 1.10A 5h2uB-3fzpA:
24.1		 5h2uB-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 439
ALA A 455
ILE A 500
LEU A 504
GLY A 508
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.08A 5h2uB-3fzpA:
24.1		 5h2uB-3fzpA:
37.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		7 LEU A  21
VAL A  29
ALA A  42
LYS A  44
LEU A 143
GLY A 158
ASP A 159
 None
 0.66A 5h2uB-3gbzA:
20.7		 5h2uB-3gbzA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		6 LEU A 226
VAL A 234
ALA A 247
ILE A 299
LEU A 303
LEU A 354
 None
 0.85A 5h2uB-3i6uA:
23.7		 5h2uB-3i6uA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		6 LEU A 226
VAL A 234
ALA A 247
LEU A 303
LEU A 354
ASP A 368
 None
 0.84A 5h2uB-3i6uA:
23.7		 5h2uB-3i6uA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  82
VAL A  90
ALA A 103
ILE A 150
LEU A 154
LEU A 205
 ANP  A 610 ( 4.5A)
ANP  A 610 (-3.9A)
ANP  A 610 ( 3.7A)
None
GOL  A   1 (-4.6A)
None
 0.82A 5h2uB-3igoA:
22.6		 5h2uB-3igoA:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 696
VAL A 704
THR A 768
GLY A 774
LEU A 822
ASP A 833
 ANP  A   1 (-4.4A)
ANP  A   1 (-3.9A)
ANP  A   1 ( 4.8A)
ANP  A   1 ( 4.9A)
ANP  A   1 (-4.7A)
MG  A1001 ( 3.1A)
 0.73A 5h2uB-3kexA:
33.4		 5h2uB-3kexA:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 649
ALA A 665
ILE A 711
THR A 713
GLY A 719
LEU A 767
ASP A 778
 None
None
None
None
GOL  A 403 (-3.4A)
None
None
 0.82A 5h2uB-3kulA:
30.6		 5h2uB-3kulA:
34.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 LEU A 680
VAL A 689
ALA A 700
ILE A 743
LEU A 747
LEU A 804
 ADP  A2101 ( 4.1A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
None
None
ADP  A2101 (-4.4A)
 0.68A 5h2uB-3lj0A:
23.2		 5h2uB-3lj0A:
24.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1005
VAL A1013
ALA A1031
LEU A1081
GLY A1085
GLY A1152
 None
None
None
None
None
CCX  A   1 (-3.6A)
 0.79A 5h2uB-3lw0A:
28.2		 5h2uB-3lw0A:
37.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 694
ALA A 719
THR A 766
LEU A 768
GLY A 772
LEU A 820
ASP A 831
 ITI  A   1 (-3.9A)
ITI  A   1 (-2.9A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.6A)
ITI  A   1 ( 4.6A)
 1.00A 5h2uB-3lzbA:
32.3		 5h2uB-3lzbA:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 694
VAL A 702
ALA A 719
LYS A 721
THR A 766
LEU A 768
LEU A 820
ASP A 831
 ITI  A   1 (-3.9A)
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.6A)
ITI  A   1 ( 4.6A)
 0.99A 5h2uB-3lzbA:
32.3		 5h2uB-3lzbA:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 ALA A 229
LEU A 259
THR A 279
GLY A 285
LEU A 339
ASP A 350
 LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.66A 5h2uB-3mdyA:
24.8		 5h2uB-3mdyA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 VAL A 218
ALA A 229
THR A 279
GLY A 285
LEU A 339
ASP A 350
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.77A 5h2uB-3mdyA:
24.8		 5h2uB-3mdyA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 216
ALA A 227
LEU A 257
THR A 277
GLY A 283
LEU A 337
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.75A 5h2uB-3my0A:
25.7		 5h2uB-3my0A:
29.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 192
VAL A 200
ALA A 213
LEU A 265
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.9A)
None
AMP  A 577 (-4.8A)
 0.55A 5h2uB-3nyoA:
18.3		 5h2uB-3nyoA:
18.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 363
ALA A 373
LEU A 406
ILE A 419
THR A 421
GLY A 485
ASP A 486
 SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
None
SM5  A   1 (-3.5A)
 0.80A 5h2uB-3omvA:
19.6		 5h2uB-3omvA:
32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1096
ALA A1112
LYS A1114
LEU A1144
GLY A1167
ASP A1226
 ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
ANP  A1358 (-3.2A)
None
None
MG  A   1 ( 3.2A)
 0.84A 5h2uB-3plsA:
31.8		 5h2uB-3plsA:
38.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 726
VAL A 734
ALA A 751
THR A 798
LEU A 800
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.50A 5h2uB-3pp0A:
31.2		 5h2uB-3pp0A:
31.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 734
ALA A 751
THR A 798
LEU A 800
GLY A 804
LEU A 852
ASP A 863
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.76A 5h2uB-3pp0A:
31.2		 5h2uB-3pp0A:
31.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 VAL A 565
ALA A 576
ILE A 623
THR A 625
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.66A 5h2uB-3ppzA:
29.2		 5h2uB-3ppzA:
30.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 206
ALA A 217
LEU A 247
THR A 267
GLY A 273
LEU A 329
ASP A 340
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
None
 0.69A 5h2uB-3q4tA:
25.1		 5h2uB-3q4tA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL B 603
ALA B 616
ILE B 884
LEU B 888
GLY B 952
ASP B 953
 None
 0.69A 5h2uB-3qd2B:
16.1		 5h2uB-3qd2B:
25.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 423
VAL A 431
ALA A 443
ILE A 487
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.62A 5h2uB-3sxsA:
32.4		 5h2uB-3sxsA:
43.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 423
VAL A 431
ALA A 443
LYS A 445
ILE A 487
THR A 489
GLY A 495
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
 0.82A 5h2uB-3sxsA:
32.4		 5h2uB-3sxsA:
43.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 484
VAL A 492
ALA A 512
GLY A 567
LEU A 630
ASP A 641
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
07J  A   1 (-4.7A)
 0.89A 5h2uB-3tt0A:
28.9		 5h2uB-3tt0A:
35.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		8 LEU A 295
VAL A 303
ALA A 315
LEU A 347
GLY A 369
LEU A 423
GLY A 433
ASP A 434
 None
 0.59A 5h2uB-3ulzA:
18.5		 5h2uB-3ulzA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 LEU A 295
VAL A 303
ALA A 315
LYS A 317
LEU A 347
GLY A 433
ASP A 434
 None
 0.85A 5h2uB-3ulzA:
18.5		 5h2uB-3ulzA:
26.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 544
VAL A 552
ALA A 570
GLY A 623
LEU A 686
GLY A 696
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
0F4  A 902 (-3.3A)
 0.60A 5h2uB-3v5qA:
17.8		 5h2uB-3v5qA:
36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  59
VAL A  67
ALA A  80
ILE A 127
LEU A 131
LEU A 186
ASP A 197
 None
ANK  A 401 (-4.3A)
ANK  A 401 (-3.0A)
None
None
ANK  A 401 ( 4.9A)
MG  A 402 ( 2.8A)
 0.85A 5h2uB-3vn9A:
19.3		 5h2uB-3vn9A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 139
VAL A 147
ALA A 160
LEU A 194
GLY A 216
LEU A 263
 N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-4.9A)
N13  A 501 (-3.5A)
N13  A 501 (-4.5A)
 0.84A 5h2uB-3w18A:
23.0		 5h2uB-3w18A:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  75
VAL A  83
ALA A  96
ILE A 142
GLY A 150
LEU A 198
ASP A 209
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
 0.65A 5h2uB-3wigA:
26.2		 5h2uB-3wigA:
29.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
VAL A 848
ALA A 866
GLY A 922
LEU A1035
ASP A1046
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.72A 5h2uB-3wzdA:
29.8		 5h2uB-3wzdA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A1978
LEU A2010
ILE A2024
LEU A2028
GLY A2031
LEU A2086
GLY A2101
 VGH  A3000 (-3.4A)
VGH  A3000 (-4.8A)
None
VGH  A3000 ( 4.8A)
None
VGH  A3000 (-4.3A)
VGH  A3000 (-3.5A)
 1.03A 5h2uB-3zbfA:
25.2		 5h2uB-3zbfA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1951
LEU A2010
GLY A2032
LEU A2086
GLY A2101
ASP A2102
 VGH  A3000 ( 4.4A)
VGH  A3000 (-4.8A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
VGH  A3000 (-3.5A)
None
 0.75A 5h2uB-3zbfA:
25.2		 5h2uB-3zbfA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A1951
VAL A1959
ALA A1978
LEU A2010
ILE A2024
LEU A2028
GLY A2032
LEU A2086
GLY A2101
 VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 (-4.8A)
None
VGH  A3000 ( 4.8A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
VGH  A3000 (-3.5A)
 0.66A 5h2uB-3zbfA:
25.2		 5h2uB-3zbfA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 633
ALA A 649
ILE A 695
THR A 697
GLY A 703
LEU A 751
ASP A 762
 None
 0.71A 5h2uB-3zfxA:
31.1		 5h2uB-3zfxA:
38.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  83
VAL A  91
ALA A 104
LEU A 138
GLY A 160
LEU A 207
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
None
VX6  A 500 (-3.3A)
VX6  A 500 (-4.6A)
 0.69A 5h2uB-4af3A:
20.3		 5h2uB-4af3A:
26.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 560
VAL A 568
ALA A 586
GLY A 639
LEU A 699
GLY A 709
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
LTI  A1839 (-3.4A)
 0.66A 5h2uB-4at3A:
30.8		 5h2uB-4at3A:
36.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 105
ALA A 121
ILE A 167
THR A 169
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.88A 5h2uB-4aw5A:
26.5		 5h2uB-4aw5A:
38.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  68
ALA A  89
ILE A 137
LEU A 141
GLY A 202
ASP A 203
 9ZP  A1333 (-3.9A)
9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.7A)
9ZP  A1333 ( 4.4A)
None
 0.78A 5h2uB-4b6lA:
24.6		 5h2uB-4b6lA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  42
VAL A  50
ALA A  63
GLY A 116
LEU A 164
ASP A 175
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
XZN  A1317 (-3.2A)
 0.75A 5h2uB-4bc6A:
21.5		 5h2uB-4bc6A:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  42
VAL A  50
ALA A  63
ILE A 108
GLY A 116
LEU A 164
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-4.4A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
 0.76A 5h2uB-4bc6A:
21.5		 5h2uB-4bc6A:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 VAL A 222
ALA A 233
LEU A 263
THR A 283
GLY A 289
LEU A 343
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.80A 5h2uB-4c02A:
25.1		 5h2uB-4c02A:
28.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 VAL A 575
ALA A 588
LYS A 590
ILE A 634
LEU A 638
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.90A 5h2uB-4e93A:
32.4		 5h2uB-4e93A:
33.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 515
VAL A 523
ALA A 541
GLY A 594
LEU A 656
GLY A 666
 None
 0.58A 5h2uB-4f0iA:
29.2		 5h2uB-4f0iA:
33.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 377
VAL A 385
ALA A 400
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.65A 5h2uB-4f4pA:
29.5		 5h2uB-4f4pA:
38.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 LEU A 377
VAL A 385
ALA A 400
GLY A 454
LEU A 501
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.49A 5h2uB-4fl3A:
33.2		 5h2uB-4fl3A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 LEU A 377
VAL A 385
LYS A 402
GLY A 454
LEU A 501
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-2.7A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.86A 5h2uB-4fl3A:
33.2		 5h2uB-4fl3A:
21.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A1122
VAL A1130
ALA A1148
ILE A1194
LEU A1198
GLY A1202
LEU A1256
GLY A1269
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.8A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 (-4.5A)
 0.60A 5h2uB-4fodA:
23.4		 5h2uB-4fodA:
34.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		7 VAL A 416
ALA A 429
ILE A 469
LEU A 473
GLY A 477
LEU A 524
ASP A 536
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.9A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.70A 5h2uB-4g3fA:
23.6		 5h2uB-4g3fA:
24.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 855
VAL A 863
ALA A 880
GLY A 935
LEU A 983
GLY A 993
 IZA  A2001 (-3.7A)
None
IZA  A2001 (-3.4A)
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
None
 0.64A 5h2uB-4gl9A:
27.0		 5h2uB-4gl9A:
33.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 855
VAL A 863
GLY A 935
LEU A 983
GLY A 993
ASP A 994
 IZA  A2001 (-3.7A)
None
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
None
IZA  A2001 ( 4.5A)
 0.73A 5h2uB-4gl9A:
27.0		 5h2uB-4gl9A:
33.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		7 LEU A 132
VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 269
ASP A 270
 None
 0.84A 5h2uB-4hzsA:
24.1		 5h2uB-4hzsA:
34.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		9 LEU A 132
VAL A 140
ALA A 156
THR A 205
LEU A 207
GLY A 211
LEU A 259
GLY A 269
ASP A 270
 None
 0.71A 5h2uB-4hzsA:
24.1		 5h2uB-4hzsA:
34.51