SIMILAR PATTERNS OF AMINO ACIDS FOR 5H2U_A_1N1A501_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al8 GLYCOLATE OXIDASE

(Spinacia
oleracea)
PF01070
(FMN_dh)
3 ILE A  45
MET A 338
ASP A 293
None
0.83A 5h2uA-1al8A:
undetectable
5h2uA-1al8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)


(Rattus
norvegicus)
PF00043
(GST_C)
PF02798
(GST_N)
3 ILE A 207
MET A 197
ASP A 161
None
0.77A 5h2uA-1b4pA:
undetectable
5h2uA-1b4pA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bc5 CHEMOTAXIS RECEPTOR
METHYLTRANSFERASE


(Salmonella
enterica)
PF01739
(CheR)
PF03705
(CheR_N)
3 ILE A  86
MET A 233
ASP A 154
None
None
SAH  A 287 (-2.8A)
0.85A 5h2uA-1bc5A:
undetectable
5h2uA-1bc5A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxn PROTEIN (RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN)


(Cupriavidus
necator)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
3 ILE A 267
MET A 253
ASP A 205
None
0.85A 5h2uA-1bxnA:
undetectable
5h2uA-1bxnA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c72 PROTEIN (GLUTATHIONE
S-TRANSFERASE)


(Gallus gallus)
PF00043
(GST_C)
PF02798
(GST_N)
3 ILE A 207
MET A 197
ASP A 161
None
0.84A 5h2uA-1c72A:
undetectable
5h2uA-1c72A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmu BGLI RESTRICTION
ENDONUCLEASE


(Bacillus
subtilis)
PF14562
(Endonuc_BglI)
3 ILE A 206
MET A 139
ASP A 135
None
0.81A 5h2uA-1dmuA:
undetectable
5h2uA-1dmuA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE


(Homo sapiens)
PF00490
(ALAD)
3 ILE A 178
MET A 250
ASP A 169
None
0.75A 5h2uA-1e51A:
undetectable
5h2uA-1e51A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE


(Pseudomonas
aeruginosa)
PF00490
(ALAD)
3 ILE A 185
MET A 258
ASP A 176
None
0.72A 5h2uA-1gzgA:
undetectable
5h2uA-1gzgA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h14 ENDO-1,4-BETA-XYLANA
SE


(Pseudoalteromonas
haloplanktis)
PF01270
(Glyco_hydro_8)
3 ILE A 173
MET A 184
ASP A 221
None
0.80A 5h2uA-1h14A:
0.2
5h2uA-1h14A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg8 ENDOPOLYGALACTURONAS
E


(Fusarium
verticillioides)
PF00295
(Glyco_hydro_28)
3 ILE A 238
MET A 228
ASP A 213
None
0.81A 5h2uA-1hg8A:
undetectable
5h2uA-1hg8A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwa RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT


(Galdieria
partita)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
3 ILE A 264
MET A 250
ASP A 202
None
0.79A 5h2uA-1iwaA:
undetectable
5h2uA-1iwaA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kv9 TYPE II
QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE


(Pseudomonas
putida)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3)
3 ILE A 605
MET A 539
ASP A 107
HEM  A 901 (-4.2A)
None
None
0.67A 5h2uA-1kv9A:
undetectable
5h2uA-1kv9A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltd FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae)
PF00173
(Cyt-b5)
PF01070
(FMN_dh)
3 ILE A 164
MET A 462
ASP A 417
None
0.84A 5h2uA-1ltdA:
undetectable
5h2uA-1ltdA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE


(Bacillus
subtilis)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
3 ILE A 200
MET A   1
ASP A 206
None
0.75A 5h2uA-1mdfA:
undetectable
5h2uA-1mdfA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1


(Streptomyces
coelicolor)
PF00067
(p450)
3 ILE A 215
MET A 239
ASP A 209
None
HEM  A1407 (-3.6A)
None
0.85A 5h2uA-1odoA:
undetectable
5h2uA-1odoA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1omx ALPHA-1,4-N-ACETYLHE
XOSAMINYLTRANSFERASE
EXTL2


(Mus musculus)
PF09258
(Glyco_transf_64)
3 ILE A 263
MET A 249
ASP A 173
EDO  A 401 ( 4.8A)
None
None
0.72A 5h2uA-1omxA:
undetectable
5h2uA-1omxA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0n ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE


(Bacillus
subtilis)
PF01070
(FMN_dh)
3 ILE A  28
MET A 310
ASP A 265
None
0.83A 5h2uA-1p0nA:
undetectable
5h2uA-1p0nA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcw FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae)
PF01070
(FMN_dh)
3 ILE A 164
MET A 462
ASP A 417
None
0.82A 5h2uA-1qcwA:
undetectable
5h2uA-1qcwA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
3 ILE A 145
MET A 150
ASP A 212
5EA  A1001 ( 3.7A)
None
MG  A 536 (-3.3A)
0.73A 5h2uA-1s9iA:
17.7
5h2uA-1s9iA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE


(Thermus
thermophilus)
PF01070
(FMN_dh)
3 ILE A 247
MET A 185
ASP A 280
None
0.76A 5h2uA-1vcgA:
undetectable
5h2uA-1vcgA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqr HYPOTHETICAL PROTEIN
CJ0248


(Campylobacter
jejuni)
PF08668
(HDOD)
3 ILE A 101
MET A  91
ASP A  49
None
0.86A 5h2uA-1vqrA:
undetectable
5h2uA-1vqrA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E


(Pyrococcus
abyssi)
PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD)
3 ILE C 169
MET C  88
ASP C 181
None
0.84A 5h2uA-1zq1C:
undetectable
5h2uA-1zq1C:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE


(Prosthecochloris
vibrioformis)
PF00490
(ALAD)
3 ILE A 180
MET A 251
ASP A 171
None
0.71A 5h2uA-2c1hA:
undetectable
5h2uA-2c1hA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox)
PF00491
(Arginase)
3 ILE A 275
MET A  27
ASP A  21
None
0.68A 5h2uA-2cevA:
undetectable
5h2uA-2cevA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE


(Brassica juncea)
PF04107
(GCS2)
3 ILE A 213
MET A 224
ASP A 237
None
BSC  A   2 ( 4.2A)
None
0.76A 5h2uA-2gwcA:
undetectable
5h2uA-2gwcA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
3 ILE A 336
MET A 341
ASP A 404
H8H  A 534 ( 4.5A)
None
H8H  A 534 (-4.2A)
0.74A 5h2uA-2h8hA:
36.2
5h2uA-2h8hA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8q RED FLUORESCENT
PROTEIN DRFP583


(Discosoma sp.)
PF01353
(GFP)
3 ILE A 119
MET A  83
ASP A 110
None
0.76A 5h2uA-2h8qA:
undetectable
5h2uA-2h8qA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
3 ILE A 336
MET A 341
ASP A 404
None
0.66A 5h2uA-2hckA:
33.8
5h2uA-2hckA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
3 ILE A 864
MET A 533
ASP A 560
None
0.80A 5h2uA-2iukA:
undetectable
5h2uA-2iukA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixd LMBE-RELATED PROTEIN

(Bacillus cereus)
PF02585
(PIG-L)
3 ILE A  18
MET A 218
ASP A 108
None
0.78A 5h2uA-2ixdA:
undetectable
5h2uA-2ixdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2onk MOLYBDATE/TUNGSTATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN


(Archaeoglobus
fulgidus)
PF00005
(ABC_tran)
3 ILE A 180
MET A   1
ASP A 195
None
0.74A 5h2uA-2onkA:
undetectable
5h2uA-2onkA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE


(Severe acute
respiratory
syndrome-related
coronavirus)
PF06471
(NSP11)
3 ILE A 295
MET A 271
ASP A 323
None
0.83A 5h2uA-2ozkA:
undetectable
5h2uA-2ozkA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjq ADAMTS-5

(Homo sapiens)
PF01421
(Reprolysin)
3 ILE A 442
MET A 381
ASP A 377
BAT  A 559 (-4.3A)
BAT  A 559 ( 3.7A)
BAT  A 559 (-3.7A)
0.82A 5h2uA-2rjqA:
undetectable
5h2uA-2rjqA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vad RED FLUORESCENT
PROTEIN


(Discosoma sp.)
PF01353
(GFP)
3 ILE A 119
MET A  83
ASP A 110
None
CL  A1227 (-4.6A)
None
0.81A 5h2uA-2vadA:
undetectable
5h2uA-2vadA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlg SPORULATION KINASE A

(Bacillus
subtilis)
PF08447
(PAS_3)
3 ILE A  86
MET A 111
ASP A  58
None
0.78A 5h2uA-2vlgA:
undetectable
5h2uA-2vlgA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1b DELTA-AMINOLEVULINIC
ACID DEHYDRATASE


(Mus musculus)
PF00490
(ALAD)
3 ILE A 178
MET A 250
ASP A 169
None
0.81A 5h2uA-2z1bA:
undetectable
5h2uA-2z1bA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aja PUTATIVE
UNCHARACTERIZED
PROTEIN


(Mycolicibacterium
smegmatis)
PF01083
(Cutinase)
3 ILE A 207
MET A 214
ASP A 269
None
0.71A 5h2uA-3ajaA:
undetectable
5h2uA-3ajaA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE


(Sulfolobus
shibatae)
PF01070
(FMN_dh)
3 ILE A 123
MET A 128
ASP A 216
None
0.69A 5h2uA-3b05A:
undetectable
5h2uA-3b05A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1


(Saccharomyces
cerevisiae)
PF00180
(Iso_dh)
3 ILE A 186
MET A 238
ASP A 217
None
0.78A 5h2uA-3blwA:
undetectable
5h2uA-3blwA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9h ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN


(Agrobacterium
fabrum)
PF13416
(SBP_bac_8)
3 ILE A 345
MET A 205
ASP A 177
None
0.72A 5h2uA-3c9hA:
undetectable
5h2uA-3c9hA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cu5 TWO COMPONENT
TRANSCRIPTIONAL
REGULATOR, ARAC
FAMILY


(Lachnoclostridium
phytofermentans)
PF00072
(Response_reg)
3 ILE A 101
MET A  59
ASP A  69
None
0.84A 5h2uA-3cu5A:
undetectable
5h2uA-3cu5A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7a UPF0201 PROTEIN
PH1010


(Pyrococcus
horikoshii)
PF01877
(RNA_binding)
3 ILE A 137
MET A 124
ASP A  71
None
0.65A 5h2uA-3d7aA:
undetectable
5h2uA-3d7aA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpi NAD+ SYNTHETASE

(Burkholderia
pseudomallei)
PF02540
(NAD_synthase)
3 ILE A  56
MET A 176
ASP A 221
None
0.77A 5h2uA-3dpiA:
undetectable
5h2uA-3dpiA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN


(Geobacillus
kaustophilus)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
3 ILE A 239
MET A 269
ASP A 273
None
0.85A 5h2uA-3f2bA:
undetectable
5h2uA-3f2bA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs6 BETA-HEXOSAMINIDASE

(Vibrio cholerae)
PF00933
(Glyco_hydro_3)
3 ILE A  57
MET A 155
ASP A 109
None
0.79A 5h2uA-3gs6A:
undetectable
5h2uA-3gs6A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htm SPECKLE-TYPE POZ
PROTEIN


(Homo sapiens)
PF00651
(BTB)
3 ILE A 217
MET A 228
ASP A 201
None
0.84A 5h2uA-3htmA:
undetectable
5h2uA-3htmA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iiw POLYCOMB PROTEIN EED

(Homo sapiens)
PF00400
(WD40)
3 ILE A 193
MET A 256
ASP A 212
None
0.72A 5h2uA-3iiwA:
undetectable
5h2uA-3iiwA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqx TAIL-ANCHORED
PROTEIN TARGETING
FACTOR GET3


(Chaetomium
thermophilum)
PF02374
(ArsA_ATPase)
3 ILE A 332
MET A  14
ASP A  23
None
0.83A 5h2uA-3iqxA:
undetectable
5h2uA-3iqxA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuu PUTATIVE
METALLOPEPTIDASE


(Chelativorans
sp. BNC1)
PF07171
(MlrC_C)
PF07364
(DUF1485)
3 ILE A  75
MET A 304
ASP A  27
None
IMD  A 496 ( 4.6A)
None
0.82A 5h2uA-3iuuA:
undetectable
5h2uA-3iuuA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkz UNCHARACTERIZED
PROTEIN Q5LES9


(Bacteroides
fragilis)
PF13649
(Methyltransf_25)
3 ILE A  53
MET A  62
ASP A  76
None
None
SAM  A 301 (-2.8A)
0.81A 5h2uA-3kkzA:
undetectable
5h2uA-3kkzA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm6 STAGE V SPORULATION
PROTEIN AD


(Bacillus
subtilis)
PF07451
(SpoVAD)
3 ILE A 265
MET A 114
ASP A 260
None
0.79A 5h2uA-3lm6A:
undetectable
5h2uA-3lm6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE


(Toxoplasma
gondii)
PF00490
(ALAD)
3 ILE A 193
MET A 265
ASP A 184
None
0.66A 5h2uA-3obkA:
undetectable
5h2uA-3obkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi3 HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A


(Homo sapiens)
PF00233
(PDEase_I)
3 ILE A 454
MET A 410
ASP A 488
None
0.77A 5h2uA-3qi3A:
undetectable
5h2uA-3qi3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2


(Rattus
norvegicus)
PF01070
(FMN_dh)
3 ILE A  44
MET A 331
ASP A 286
None
0.79A 5h2uA-3sgzA:
undetectable
5h2uA-3sgzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlz MCCF

(Escherichia
coli)
PF02016
(Peptidase_S66)
3 ILE A 301
MET A 258
ASP A 266
None
0.74A 5h2uA-3tlzA:
undetectable
5h2uA-3tlzA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsj 2-AMINO-5-CHLOROPHEN
OL 1,6-DIOXYGENASE
BETA SUBUNIT


(Comamonas
testosteroni)
PF02900
(LigB)
3 ILE B  64
MET B 120
ASP B 128
None
0.74A 5h2uA-3vsjB:
undetectable
5h2uA-3vsjB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvc CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP8E


(Staphylococcus
aureus)
PF02719
(Polysacc_synt_2)
PF08485
(Polysacc_syn_2C)
3 ILE A  58
MET A  71
ASP A  63
None
0.85A 5h2uA-3vvcA:
undetectable
5h2uA-3vvcA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
3 ILE A 142
MET A 147
ASP A 209
CHU  A 403 (-3.8A)
None
MG  A 402 (-3.2A)
0.69A 5h2uA-3wigA:
18.9
5h2uA-3wigA:
29.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
3 ILE A 695
MET A 700
ASP A 762
None
0.77A 5h2uA-3zfxA:
30.9
5h2uA-3zfxA:
38.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0s DEAMIDASE-DEPUPYLASE
DOP


(Acidothermus
cellulolyticus)
PF03136
(Pup_ligase)
3 ILE A 174
MET A 267
ASP A 276
None
0.80A 5h2uA-4b0sA:
undetectable
5h2uA-4b0sA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp8 ALLOPHANATE
HYDROLASE


(Pseudomonas sp.
ADP)
PF01425
(Amidase)
3 ILE A 305
MET A 300
ASP A 384
None
0.72A 5h2uA-4cp8A:
undetectable
5h2uA-4cp8A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dia 2-PYRONE-4,6-DICARBA
XYLATE HYDROLASE


(Sphingomonas
paucimobilis)
PF04909
(Amidohydro_2)
3 ILE A  73
MET A 287
ASP A  29
None
0.63A 5h2uA-4diaA:
undetectable
5h2uA-4diaA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ea1 DEHYDROSQUALENE
SYNTHASE


(Staphylococcus
aureus)
PF00494
(SQS_PSY)
3 ILE A  14
MET A   4
ASP A  83
None
0.66A 5h2uA-4ea1A:
undetectable
5h2uA-4ea1A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Zea mays)
PF00145
(DNA_methylase)
PF00385
(Chromo)
PF01426
(BAH)
3 ILE A 287
MET A 296
ASP A 247
None
0.73A 5h2uA-4ft2A:
undetectable
5h2uA-4ft2A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu4 ARGINASE

(Leishmania
mexicana)
PF00491
(Arginase)
3 ILE A  93
MET A  15
ASP A 285
None
0.75A 5h2uA-4iu4A:
undetectable
5h2uA-4iu4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8l UNCHARACTERIZED
PROTEIN YHFS


(Escherichia
coli)
PF00155
(Aminotran_1_2)
3 ILE A 116
MET A 111
ASP A 136
None
0.81A 5h2uA-4j8lA:
undetectable
5h2uA-4j8lA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8z SPECKLE-TYPE POZ
PROTEIN


(Homo sapiens)
PF00651
(BTB)
3 ILE A 217
MET A 228
ASP A 201
None
0.86A 5h2uA-4j8zA:
undetectable
5h2uA-4j8zA:
24.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
3 ILE A 336
MET A 341
ASP A 404
0J9  A 601 (-4.4A)
None
0J9  A 601 (-3.1A)
0.72A 5h2uA-4k11A:
30.8
5h2uA-4k11A:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kem MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Azospirillum
lipoferum)
PF13378
(MR_MLE_C)
3 ILE A 219
MET A 281
ASP A 245
None
0.80A 5h2uA-4kemA:
undetectable
5h2uA-4kemA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le5 S-ADENOSYLMETHIONINE
SYNTHETASE


(Campylobacter
jejuni)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
3 ILE A 307
MET A 343
ASP A 335
None
0.67A 5h2uA-4le5A:
undetectable
5h2uA-4le5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mju NEURAMINIDASE

(Influenza A
virus)
PF00064
(Neur)
3 ILE A 379
MET A 341
ASP A 330
None
0.85A 5h2uA-4mjuA:
undetectable
5h2uA-4mjuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzj PUTATIVE
ALPHA-GALACTOSIDASE


(Bacteroides
fragilis)
PF05345
(He_PIG)
PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2)
3 ILE A  43
MET A  88
ASP A  93
None
0.83A 5h2uA-4nzjA:
2.0
5h2uA-4nzjA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Chromohalobacter
salexigens)
PF03480
(DctP)
3 ILE A 146
MET A 128
ASP A 138
None
0.85A 5h2uA-4p1lA:
undetectable
5h2uA-4p1lA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE


(Homo sapiens)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
3 ILE A 320
MET A 188
ASP A 322
None
None
NAG  A1103 (-3.1A)
0.81A 5h2uA-4pj6A:
undetectable
5h2uA-4pj6A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psw HISTONE
ACETYLTRANSFERASE
TYPE B SUBUNIT 2


(Saccharomyces
cerevisiae)
PF00400
(WD40)
PF12265
(CAF1C_H4-bd)
3 ILE B 211
MET B 272
ASP B 230
None
0.84A 5h2uA-4pswB:
undetectable
5h2uA-4pswB:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tl9 CIRCADIAN CLOCK
PROTEIN KINASE KAIC


(Synechococcus
elongatus)
PF06745
(ATPase)
3 ILE A  65
MET A  21
ASP A  68
None
0.77A 5h2uA-4tl9A:
undetectable
5h2uA-4tl9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjs RSA4

(Chaetomium
thermophilum)
PF00400
(WD40)
3 ILE A 149
MET A 209
ASP A 168
None
0.77A 5h2uA-4wjsA:
undetectable
5h2uA-4wjsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjv RIBOSOME ASSEMBLY
PROTEIN 4


(Saccharomyces
cerevisiae)
PF00400
(WD40)
3 ILE A 146
MET A 206
ASP A 165
None
0.78A 5h2uA-4wjvA:
undetectable
5h2uA-4wjvA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK


(Mus musculus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
3 ILE A 472
MET A 477
ASP A 539
None
0.68A 5h2uA-4xi2A:
34.0
5h2uA-4xi2A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE


(Bos taurus)
PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr)
3 ILE A 472
MET A 477
ASP A 539
None
None
746  A 702 (-3.7A)
0.67A 5h2uA-4y93A:
34.7
5h2uA-4y93A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE


(Thermoplasma
acidophilum)
PF01884
(PcrB)
3 ILE A  64
MET A  19
ASP A  90
None
0.68A 5h2uA-5b69A:
undetectable
5h2uA-5b69A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt1 HAT1-INTERACTING
FACTOR 1


(Saccharomyces
cerevisiae)
no annotation 3 ILE A  66
MET A 215
ASP A  60
None
0.79A 5h2uA-5bt1A:
undetectable
5h2uA-5bt1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP2

(Deformed wing
virus)
PF00073
(Rhv)
3 ILE B  58
MET B 119
ASP B  54
None
0.80A 5h2uA-5g52B:
undetectable
5h2uA-5g52B:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gri ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT ALPHA,
MITOCHONDRIAL


(Homo sapiens)
PF00180
(Iso_dh)
3 ILE A 176
MET A 224
ASP A 206
None
0.85A 5h2uA-5griA:
undetectable
5h2uA-5griA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 MYOSIN LIGHT CHAIN
1/3, SKELETAL MUSCLE
ISOFORM
SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL


(Oryctolagus
cuniculus)
PF00063
(Myosin_head)
PF02736
(Myosin_N)
PF13405
(EF-hand_6)
3 ILE C 180
MET A 789
ASP C 129
None
0.83A 5h2uA-5h53C:
undetectable
5h2uA-5h53C:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)


(Helicobacter
pylori)
PF01555
(N6_N4_Mtase)
3 ILE A  13
MET A 196
ASP A   8
None
None
SAM  A 301 (-3.4A)
0.71A 5h2uA-5hfjA:
undetectable
5h2uA-5hfjA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ica PERIODIC TRYPTOPHAN
PROTEIN 2-LIKE
PROTEIN
PUTATIVE U3 SNORNP
PROTEIN


(Chaetomium
thermophilum)
PF04003
(Utp12)
PF04192
(Utp21)
3 ILE D 830
MET C 995
ASP D 835
None
0.62A 5h2uA-5icaD:
undetectable
5h2uA-5icaD:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1


(Mus musculus)
PF01094
(ANF_receptor)
3 ILE A 262
MET A 315
ASP A 264
None
None
EDO  A 503 ( 3.8A)
0.78A 5h2uA-5kc9A:
undetectable
5h2uA-5kc9A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kel C2G4 VARIABLE FAB
DOMAIN HEAVY CHAIN
C2G4 VARIABLE FAB
DOMAIN LIGHT CHAIN


(Homo sapiens)
PF07686
(V-set)
3 ILE L  53
MET H 100
ASP L  56
None
0.68A 5h2uA-5kelL:
undetectable
5h2uA-5kelL:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lad PUTATIVE GTP-BINDING
PROTEIN


(Thermotoga
maritima)
PF01926
(MMR_HSR1)
3 ILE A 244
MET A 238
ASP A 183
None
0.79A 5h2uA-5ladA:
undetectable
5h2uA-5ladA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5med ARACHIDONATE
15-LIPOXYGENASE


(Cyanothece sp.
PCC 8801)
PF00305
(Lipoxygenase)
3 ILE A 353
MET A 119
ASP A 371
None
0.73A 5h2uA-5medA:
undetectable
5h2uA-5medA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR


(Homo sapiens)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R)
3 ILE A 255
MET A 245
ASP A 985
None
0.71A 5h2uA-5uakA:
undetectable
5h2uA-5uakA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5urp TOXIN 2A

(Paenibacillus
larvae)
no annotation 3 ILE A   6
MET A 169
ASP A   3
None
0.77A 5h2uA-5urpA:
undetectable
5h2uA-5urpA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wru PROBABLE INORGANIC
PYROPHOSPHATASE


(Plasmodium
falciparum)
no annotation 3 ILE A  65
MET A  81
ASP A  67
None
0.82A 5h2uA-5wruA:
undetectable
5h2uA-5wruA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT


(Desulfovibrio
gigas)
no annotation 3 ILE A  88
MET A 590
ASP A  82
None
0.77A 5h2uA-5xmjA:
undetectable
5h2uA-5xmjA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4k DMSP LYASE DDDY

(Acinetobacter
bereziniae)
no annotation 3 ILE A 192
MET A 272
ASP A 189
None
0.77A 5h2uA-5y4kA:
undetectable
5h2uA-5y4kA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1


(Saccharomyces
cerevisiae)
no annotation 3 ILE A 664
MET A 635
ASP A 669
None
0.77A 5h2uA-6az0A:
undetectable
5h2uA-6az0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE


(Bacillus
licheniformis)
no annotation 3 ILE A 186
MET A 162
ASP A 136
None
0.76A 5h2uA-6b7kA:
undetectable
5h2uA-6b7kA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml IES6

(Chaetomium
thermophilum)
no annotation 3 ILE I 193
MET I 204
ASP I 171
None
0.79A 5h2uA-6fmlI:
undetectable
5h2uA-6fmlI:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3


(Rattus rattus)
PF00043
(GST_C)
PF02798
(GST_N)
3 ILE A 207
MET A 197
ASP A 161
None
0.81A 5h2uA-6gswA:
undetectable
5h2uA-6gswA:
21.45