SIMILAR PATTERNS OF AMINO ACIDS FOR 5H2U_A_1N1A501_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1al8 | GLYCOLATE OXIDASE (Spinaciaoleracea) |
PF01070(FMN_dh) | 3 | ILE A 45MET A 338ASP A 293 | None | 0.83A | 5h2uA-1al8A:undetectable | 5h2uA-1al8A:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b4p | PROTEIN (GLUTATHIONES-TRANSFERASE) (Rattusnorvegicus) |
PF00043(GST_C)PF02798(GST_N) | 3 | ILE A 207MET A 197ASP A 161 | None | 0.77A | 5h2uA-1b4pA:undetectable | 5h2uA-1b4pA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bc5 | CHEMOTAXIS RECEPTORMETHYLTRANSFERASE (Salmonellaenterica) |
PF01739(CheR)PF03705(CheR_N) | 3 | ILE A 86MET A 233ASP A 154 | NoneNoneSAH A 287 (-2.8A) | 0.85A | 5h2uA-1bc5A:undetectable | 5h2uA-1bc5A:23.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bxn | PROTEIN (RIBULOSEBISPHOSPHATECARBOXYLASE LARGECHAIN) (Cupriavidusnecator) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 3 | ILE A 267MET A 253ASP A 205 | None | 0.85A | 5h2uA-1bxnA:undetectable | 5h2uA-1bxnA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c72 | PROTEIN (GLUTATHIONES-TRANSFERASE) (Gallus gallus) |
PF00043(GST_C)PF02798(GST_N) | 3 | ILE A 207MET A 197ASP A 161 | None | 0.84A | 5h2uA-1c72A:undetectable | 5h2uA-1c72A:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dmu | BGLI RESTRICTIONENDONUCLEASE (Bacillussubtilis) |
PF14562(Endonuc_BglI) | 3 | ILE A 206MET A 139ASP A 135 | None | 0.81A | 5h2uA-1dmuA:undetectable | 5h2uA-1dmuA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e51 | DELTA-AMINOLEVULINICACID DEHYDRATASE (Homo sapiens) |
PF00490(ALAD) | 3 | ILE A 178MET A 250ASP A 169 | None | 0.75A | 5h2uA-1e51A:undetectable | 5h2uA-1e51A:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gzg | DELTA-AMINOLEVULINICACID DEHYDRATASE (Pseudomonasaeruginosa) |
PF00490(ALAD) | 3 | ILE A 185MET A 258ASP A 176 | None | 0.72A | 5h2uA-1gzgA:undetectable | 5h2uA-1gzgA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h14 | ENDO-1,4-BETA-XYLANASE (Pseudoalteromonashaloplanktis) |
PF01270(Glyco_hydro_8) | 3 | ILE A 173MET A 184ASP A 221 | None | 0.80A | 5h2uA-1h14A:0.2 | 5h2uA-1h14A:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hg8 | ENDOPOLYGALACTURONASE (Fusariumverticillioides) |
PF00295(Glyco_hydro_28) | 3 | ILE A 238MET A 228ASP A 213 | None | 0.81A | 5h2uA-1hg8A:undetectable | 5h2uA-1hg8A:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iwa | RIBULOSE-1,5-BISPHOSPHATECARBOXYLASE/OXYGENASE LARGE SUBUNIT (Galdieriapartita) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 3 | ILE A 264MET A 250ASP A 202 | None | 0.79A | 5h2uA-1iwaA:undetectable | 5h2uA-1iwaA:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kv9 | TYPE IIQUINOHEMOPROTEINALCOHOLDEHYDROGENASE (Pseudomonasputida) |
PF13360(PQQ_2)PF13442(Cytochrome_CBB3) | 3 | ILE A 605MET A 539ASP A 107 | HEM A 901 (-4.2A)NoneNone | 0.67A | 5h2uA-1kv9A:undetectable | 5h2uA-1kv9A:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ltd | FLAVOCYTOCHROME B2 (Saccharomycescerevisiae) |
PF00173(Cyt-b5)PF01070(FMN_dh) | 3 | ILE A 164MET A 462ASP A 417 | None | 0.84A | 5h2uA-1ltdA:undetectable | 5h2uA-1ltdA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mdf | 2,3-DIHYDROXYBENZOATE-AMP LIGASE (Bacillussubtilis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 3 | ILE A 200MET A 1ASP A 206 | None | 0.75A | 5h2uA-1mdfA:undetectable | 5h2uA-1mdfA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1odo | PUTATIVE CYTOCHROMEP450 154A1 (Streptomycescoelicolor) |
PF00067(p450) | 3 | ILE A 215MET A 239ASP A 209 | NoneHEM A1407 (-3.6A)None | 0.85A | 5h2uA-1odoA:undetectable | 5h2uA-1odoA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1omx | ALPHA-1,4-N-ACETYLHEXOSAMINYLTRANSFERASEEXTL2 (Mus musculus) |
PF09258(Glyco_transf_64) | 3 | ILE A 263MET A 249ASP A 173 | EDO A 401 ( 4.8A)NoneNone | 0.72A | 5h2uA-1omxA:undetectable | 5h2uA-1omxA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p0n | ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE (Bacillussubtilis) |
PF01070(FMN_dh) | 3 | ILE A 28MET A 310ASP A 265 | None | 0.83A | 5h2uA-1p0nA:undetectable | 5h2uA-1p0nA:23.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qcw | FLAVOCYTOCHROME B2 (Saccharomycescerevisiae) |
PF01070(FMN_dh) | 3 | ILE A 164MET A 462ASP A 417 | None | 0.82A | 5h2uA-1qcwA:undetectable | 5h2uA-1qcwA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s9i | DUAL SPECIFICITYMITOGEN-ACTIVATEDPROTEIN KINASEKINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 3 | ILE A 145MET A 150ASP A 212 | 5EA A1001 ( 3.7A)None MG A 536 (-3.3A) | 0.73A | 5h2uA-1s9iA:17.7 | 5h2uA-1s9iA:27.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vcg | ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE (Thermusthermophilus) |
PF01070(FMN_dh) | 3 | ILE A 247MET A 185ASP A 280 | None | 0.76A | 5h2uA-1vcgA:undetectable | 5h2uA-1vcgA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vqr | HYPOTHETICAL PROTEINCJ0248 (Campylobacterjejuni) |
PF08668(HDOD) | 3 | ILE A 101MET A 91ASP A 49 | None | 0.86A | 5h2uA-1vqrA:undetectable | 5h2uA-1vqrA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zq1 | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT E (Pyrococcusabyssi) |
PF02637(GatB_Yqey)PF02934(GatB_N)PF02938(GAD) | 3 | ILE C 169MET C 88ASP C 181 | None | 0.84A | 5h2uA-1zq1C:undetectable | 5h2uA-1zq1C:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c1h | DELTA-AMINOLEVULINICACID DEHYDRATASE (Prosthecochlorisvibrioformis) |
PF00490(ALAD) | 3 | ILE A 180MET A 251ASP A 171 | None | 0.71A | 5h2uA-2c1hA:undetectable | 5h2uA-2c1hA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cev | PROTEIN (ARGINASE) ([Bacillus]caldovelox) |
PF00491(Arginase) | 3 | ILE A 275MET A 27ASP A 21 | None | 0.68A | 5h2uA-2cevA:undetectable | 5h2uA-2cevA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gwc | GLUTAMATE CYSTEINELIGASE (Brassica juncea) |
PF04107(GCS2) | 3 | ILE A 213MET A 224ASP A 237 | NoneBSC A 2 ( 4.2A)None | 0.76A | 5h2uA-2gwcA:undetectable | 5h2uA-2gwcA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h8h | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 3 | ILE A 336MET A 341ASP A 404 | H8H A 534 ( 4.5A)NoneH8H A 534 (-4.2A) | 0.74A | 5h2uA-2h8hA:36.2 | 5h2uA-2h8hA:26.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h8q | RED FLUORESCENTPROTEIN DRFP583 (Discosoma sp.) |
PF01353(GFP) | 3 | ILE A 119MET A 83ASP A 110 | None | 0.76A | 5h2uA-2h8qA:undetectable | 5h2uA-2h8qA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hck | HEMATOPOETIC CELLKINASE HCK (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 3 | ILE A 336MET A 341ASP A 404 | None | 0.66A | 5h2uA-2hckA:33.8 | 5h2uA-2hckA:29.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iuk | SEED LIPOXYGENASE (Glycine max) |
PF00305(Lipoxygenase)PF01477(PLAT) | 3 | ILE A 864MET A 533ASP A 560 | None | 0.80A | 5h2uA-2iukA:undetectable | 5h2uA-2iukA:14.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ixd | LMBE-RELATED PROTEIN (Bacillus cereus) |
PF02585(PIG-L) | 3 | ILE A 18MET A 218ASP A 108 | None | 0.78A | 5h2uA-2ixdA:undetectable | 5h2uA-2ixdA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2onk | MOLYBDATE/TUNGSTATEABC TRANSPORTER,ATP-BINDING PROTEIN (Archaeoglobusfulgidus) |
PF00005(ABC_tran) | 3 | ILE A 180MET A 1ASP A 195 | None | 0.74A | 5h2uA-2onkA:undetectable | 5h2uA-2onkA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ozk | URIDYLATE-SPECIFICENDORIBONUCLEASE (Severe acuterespiratorysyndrome-relatedcoronavirus) |
PF06471(NSP11) | 3 | ILE A 295MET A 271ASP A 323 | None | 0.83A | 5h2uA-2ozkA:undetectable | 5h2uA-2ozkA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rjq | ADAMTS-5 (Homo sapiens) |
PF01421(Reprolysin) | 3 | ILE A 442MET A 381ASP A 377 | BAT A 559 (-4.3A)BAT A 559 ( 3.7A)BAT A 559 (-3.7A) | 0.82A | 5h2uA-2rjqA:undetectable | 5h2uA-2rjqA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vad | RED FLUORESCENTPROTEIN (Discosoma sp.) |
PF01353(GFP) | 3 | ILE A 119MET A 83ASP A 110 | None CL A1227 (-4.6A)None | 0.81A | 5h2uA-2vadA:undetectable | 5h2uA-2vadA:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vlg | SPORULATION KINASE A (Bacillussubtilis) |
PF08447(PAS_3) | 3 | ILE A 86MET A 111ASP A 58 | None | 0.78A | 5h2uA-2vlgA:undetectable | 5h2uA-2vlgA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z1b | DELTA-AMINOLEVULINICACID DEHYDRATASE (Mus musculus) |
PF00490(ALAD) | 3 | ILE A 178MET A 250ASP A 169 | None | 0.81A | 5h2uA-2z1bA:undetectable | 5h2uA-2z1bA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aja | PUTATIVEUNCHARACTERIZEDPROTEIN (Mycolicibacteriumsmegmatis) |
PF01083(Cutinase) | 3 | ILE A 207MET A 214ASP A 269 | None | 0.71A | 5h2uA-3ajaA:undetectable | 5h2uA-3ajaA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b05 | ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE (Sulfolobusshibatae) |
PF01070(FMN_dh) | 3 | ILE A 123MET A 128ASP A 216 | None | 0.69A | 5h2uA-3b05A:undetectable | 5h2uA-3b05A:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3blw | ISOCITRATEDEHYDROGENASE [NAD]SUBUNIT 1 (Saccharomycescerevisiae) |
PF00180(Iso_dh) | 3 | ILE A 186MET A 238ASP A 217 | None | 0.78A | 5h2uA-3blwA:undetectable | 5h2uA-3blwA:24.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c9h | ABC TRANSPORTER,SUBSTRATE BINDINGPROTEIN (Agrobacteriumfabrum) |
PF13416(SBP_bac_8) | 3 | ILE A 345MET A 205ASP A 177 | None | 0.72A | 5h2uA-3c9hA:undetectable | 5h2uA-3c9hA:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cu5 | TWO COMPONENTTRANSCRIPTIONALREGULATOR, ARACFAMILY (Lachnoclostridiumphytofermentans) |
PF00072(Response_reg) | 3 | ILE A 101MET A 59ASP A 69 | None | 0.84A | 5h2uA-3cu5A:undetectable | 5h2uA-3cu5A:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d7a | UPF0201 PROTEINPH1010 (Pyrococcushorikoshii) |
PF01877(RNA_binding) | 3 | ILE A 137MET A 124ASP A 71 | None | 0.65A | 5h2uA-3d7aA:undetectable | 5h2uA-3d7aA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dpi | NAD+ SYNTHETASE (Burkholderiapseudomallei) |
PF02540(NAD_synthase) | 3 | ILE A 56MET A 176ASP A 221 | None | 0.77A | 5h2uA-3dpiA:undetectable | 5h2uA-3dpiA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f2b | DNA-DIRECTED DNAPOLYMERASE III ALPHACHAIN (Geobacilluskaustophilus) |
PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 3 | ILE A 239MET A 269ASP A 273 | None | 0.85A | 5h2uA-3f2bA:undetectable | 5h2uA-3f2bA:14.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gs6 | BETA-HEXOSAMINIDASE (Vibrio cholerae) |
PF00933(Glyco_hydro_3) | 3 | ILE A 57MET A 155ASP A 109 | None | 0.79A | 5h2uA-3gs6A:undetectable | 5h2uA-3gs6A:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3htm | SPECKLE-TYPE POZPROTEIN (Homo sapiens) |
PF00651(BTB) | 3 | ILE A 217MET A 228ASP A 201 | None | 0.84A | 5h2uA-3htmA:undetectable | 5h2uA-3htmA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iiw | POLYCOMB PROTEIN EED (Homo sapiens) |
PF00400(WD40) | 3 | ILE A 193MET A 256ASP A 212 | None | 0.72A | 5h2uA-3iiwA:undetectable | 5h2uA-3iiwA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iqx | TAIL-ANCHOREDPROTEIN TARGETINGFACTOR GET3 (Chaetomiumthermophilum) |
PF02374(ArsA_ATPase) | 3 | ILE A 332MET A 14ASP A 23 | None | 0.83A | 5h2uA-3iqxA:undetectable | 5h2uA-3iqxA:24.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iuu | PUTATIVEMETALLOPEPTIDASE (Chelativoranssp. BNC1) |
PF07171(MlrC_C)PF07364(DUF1485) | 3 | ILE A 75MET A 304ASP A 27 | NoneIMD A 496 ( 4.6A)None | 0.82A | 5h2uA-3iuuA:undetectable | 5h2uA-3iuuA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kkz | UNCHARACTERIZEDPROTEIN Q5LES9 (Bacteroidesfragilis) |
PF13649(Methyltransf_25) | 3 | ILE A 53MET A 62ASP A 76 | NoneNoneSAM A 301 (-2.8A) | 0.81A | 5h2uA-3kkzA:undetectable | 5h2uA-3kkzA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm6 | STAGE V SPORULATIONPROTEIN AD (Bacillussubtilis) |
PF07451(SpoVAD) | 3 | ILE A 265MET A 114ASP A 260 | None | 0.79A | 5h2uA-3lm6A:undetectable | 5h2uA-3lm6A:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3obk | DELTA-AMINOLEVULINICACID DEHYDRATASE (Toxoplasmagondii) |
PF00490(ALAD) | 3 | ILE A 193MET A 265ASP A 184 | None | 0.66A | 5h2uA-3obkA:undetectable | 5h2uA-3obkA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qi3 | HIGH AFFINITYCGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 9A (Homo sapiens) |
PF00233(PDEase_I) | 3 | ILE A 454MET A 410ASP A 488 | None | 0.77A | 5h2uA-3qi3A:undetectable | 5h2uA-3qi3A:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sgz | HYDROXYACID OXIDASE2 (Rattusnorvegicus) |
PF01070(FMN_dh) | 3 | ILE A 44MET A 331ASP A 286 | None | 0.79A | 5h2uA-3sgzA:undetectable | 5h2uA-3sgzA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tlz | MCCF (Escherichiacoli) |
PF02016(Peptidase_S66) | 3 | ILE A 301MET A 258ASP A 266 | None | 0.74A | 5h2uA-3tlzA:undetectable | 5h2uA-3tlzA:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vsj | 2-AMINO-5-CHLOROPHENOL 1,6-DIOXYGENASEBETA SUBUNIT (Comamonastestosteroni) |
PF02900(LigB) | 3 | ILE B 64MET B 120ASP B 128 | None | 0.74A | 5h2uA-3vsjB:undetectable | 5h2uA-3vsjB:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vvc | CAPSULARPOLYSACCHARIDESYNTHESIS ENZYMECAP8E (Staphylococcusaureus) |
PF02719(Polysacc_synt_2)PF08485(Polysacc_syn_2C) | 3 | ILE A 58MET A 71ASP A 63 | None | 0.85A | 5h2uA-3vvcA:undetectable | 5h2uA-3vvcA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wig | DUAL SPECIFICITYMITOGEN-ACTIVATEDPROTEIN KINASEKINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 3 | ILE A 142MET A 147ASP A 209 | CHU A 403 (-3.8A)None MG A 402 (-3.2A) | 0.69A | 5h2uA-3wigA:18.9 | 5h2uA-3wigA:29.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zfx | EPHRIN TYPE-BRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 3 | ILE A 695MET A 700ASP A 762 | None | 0.77A | 5h2uA-3zfxA:30.9 | 5h2uA-3zfxA:38.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b0s | DEAMIDASE-DEPUPYLASEDOP (Acidothermuscellulolyticus) |
PF03136(Pup_ligase) | 3 | ILE A 174MET A 267ASP A 276 | None | 0.80A | 5h2uA-4b0sA:undetectable | 5h2uA-4b0sA:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cp8 | ALLOPHANATEHYDROLASE (Pseudomonas sp.ADP) |
PF01425(Amidase) | 3 | ILE A 305MET A 300ASP A 384 | None | 0.72A | 5h2uA-4cp8A:undetectable | 5h2uA-4cp8A:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dia | 2-PYRONE-4,6-DICARBAXYLATE HYDROLASE (Sphingomonaspaucimobilis) |
PF04909(Amidohydro_2) | 3 | ILE A 73MET A 287ASP A 29 | None | 0.63A | 5h2uA-4diaA:undetectable | 5h2uA-4diaA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ea1 | DEHYDROSQUALENESYNTHASE (Staphylococcusaureus) |
PF00494(SQS_PSY) | 3 | ILE A 14MET A 4ASP A 83 | None | 0.66A | 5h2uA-4ea1A:undetectable | 5h2uA-4ea1A:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ft2 | DNA(CYTOSINE-5)-METHYLTRANSFERASE 1 (Zea mays) |
PF00145(DNA_methylase)PF00385(Chromo)PF01426(BAH) | 3 | ILE A 287MET A 296ASP A 247 | None | 0.73A | 5h2uA-4ft2A:undetectable | 5h2uA-4ft2A:16.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iu4 | ARGINASE (Leishmaniamexicana) |
PF00491(Arginase) | 3 | ILE A 93MET A 15ASP A 285 | None | 0.75A | 5h2uA-4iu4A:undetectable | 5h2uA-4iu4A:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j8l | UNCHARACTERIZEDPROTEIN YHFS (Escherichiacoli) |
PF00155(Aminotran_1_2) | 3 | ILE A 116MET A 111ASP A 136 | None | 0.81A | 5h2uA-4j8lA:undetectable | 5h2uA-4j8lA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j8z | SPECKLE-TYPE POZPROTEIN (Homo sapiens) |
PF00651(BTB) | 3 | ILE A 217MET A 228ASP A 201 | None | 0.86A | 5h2uA-4j8zA:undetectable | 5h2uA-4j8zA:24.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k11 | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 3 | ILE A 336MET A 341ASP A 404 | 0J9 A 601 (-4.4A)None0J9 A 601 (-3.1A) | 0.72A | 5h2uA-4k11A:30.8 | 5h2uA-4k11A:31.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kem | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Azospirillumlipoferum) |
PF13378(MR_MLE_C) | 3 | ILE A 219MET A 281ASP A 245 | None | 0.80A | 5h2uA-4kemA:undetectable | 5h2uA-4kemA:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4le5 | S-ADENOSYLMETHIONINESYNTHETASE (Campylobacterjejuni) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 3 | ILE A 307MET A 343ASP A 335 | None | 0.67A | 5h2uA-4le5A:undetectable | 5h2uA-4le5A:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mju | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 3 | ILE A 379MET A 341ASP A 330 | None | 0.85A | 5h2uA-4mjuA:undetectable | 5h2uA-4mjuA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nzj | PUTATIVEALPHA-GALACTOSIDASE (Bacteroidesfragilis) |
PF05345(He_PIG)PF10632(He_PIG_assoc)PF16499(Melibiase_2) | 3 | ILE A 43MET A 88ASP A 93 | None | 0.83A | 5h2uA-4nzjA:2.0 | 5h2uA-4nzjA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p1l | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Chromohalobactersalexigens) |
PF03480(DctP) | 3 | ILE A 146MET A 128ASP A 138 | None | 0.85A | 5h2uA-4p1lA:undetectable | 5h2uA-4p1lA:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pj6 | LEUCYL-CYSTINYLAMINOPEPTIDASE (Homo sapiens) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 3 | ILE A 320MET A 188ASP A 322 | NoneNoneNAG A1103 (-3.1A) | 0.81A | 5h2uA-4pj6A:undetectable | 5h2uA-4pj6A:14.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4psw | HISTONEACETYLTRANSFERASETYPE B SUBUNIT 2 (Saccharomycescerevisiae) |
PF00400(WD40)PF12265(CAF1C_H4-bd) | 3 | ILE B 211MET B 272ASP B 230 | None | 0.84A | 5h2uA-4pswB:undetectable | 5h2uA-4pswB:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tl9 | CIRCADIAN CLOCKPROTEIN KINASE KAIC (Synechococcuselongatus) |
PF06745(ATPase) | 3 | ILE A 65MET A 21ASP A 68 | None | 0.77A | 5h2uA-4tl9A:undetectable | 5h2uA-4tl9A:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wjs | RSA4 (Chaetomiumthermophilum) |
PF00400(WD40) | 3 | ILE A 149MET A 209ASP A 168 | None | 0.77A | 5h2uA-4wjsA:undetectable | 5h2uA-4wjsA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wjv | RIBOSOME ASSEMBLYPROTEIN 4 (Saccharomycescerevisiae) |
PF00400(WD40) | 3 | ILE A 146MET A 206ASP A 165 | None | 0.78A | 5h2uA-4wjvA:undetectable | 5h2uA-4wjvA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xi2 | TYROSINE-PROTEINKINASE BTK (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 3 | ILE A 472MET A 477ASP A 539 | None | 0.68A | 5h2uA-4xi2A:34.0 | 5h2uA-4xi2A:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y93 | NON-SPECIFICPROTEIN-TYROSINEKINASE,NON-SPECIFICPROTEIN-TYROSINEKINASE (Bos taurus) |
PF00169(PH)PF00779(BTK)PF07714(Pkinase_Tyr) | 3 | ILE A 472MET A 477ASP A 539 | NoneNone746 A 702 (-3.7A) | 0.67A | 5h2uA-4y93A:34.7 | 5h2uA-4y93A:24.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b69 | GERANYLGERANYLGLYCERYL PHOSPHATESYNTHASE (Thermoplasmaacidophilum) |
PF01884(PcrB) | 3 | ILE A 64MET A 19ASP A 90 | None | 0.68A | 5h2uA-5b69A:undetectable | 5h2uA-5b69A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bt1 | HAT1-INTERACTINGFACTOR 1 (Saccharomycescerevisiae) |
no annotation | 3 | ILE A 66MET A 215ASP A 60 | None | 0.79A | 5h2uA-5bt1A:undetectable | 5h2uA-5bt1A:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g52 | VP2 (Deformed wingvirus) |
PF00073(Rhv) | 3 | ILE B 58MET B 119ASP B 54 | None | 0.80A | 5h2uA-5g52B:undetectable | 5h2uA-5g52B:24.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gri | ISOCITRATEDEHYDROGENASE [NAD]SUBUNIT ALPHA,MITOCHONDRIAL (Homo sapiens) |
PF00180(Iso_dh) | 3 | ILE A 176MET A 224ASP A 206 | None | 0.85A | 5h2uA-5griA:undetectable | 5h2uA-5griA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h53 | MYOSIN LIGHT CHAIN1/3, SKELETAL MUSCLEISOFORMSKELETAL MUSCLEMYOSIN HEAVY CHAINMYHC-EO/IIL (Oryctolaguscuniculus) |
PF00063(Myosin_head)PF02736(Myosin_N)PF13405(EF-hand_6) | 3 | ILE C 180MET A 789ASP C 129 | None | 0.83A | 5h2uA-5h53C:undetectable | 5h2uA-5h53C:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hfj | ADENINE SPECIFIC DNAMETHYLTRANSFERASE(DPNA) (Helicobacterpylori) |
PF01555(N6_N4_Mtase) | 3 | ILE A 13MET A 196ASP A 8 | NoneNoneSAM A 301 (-3.4A) | 0.71A | 5h2uA-5hfjA:undetectable | 5h2uA-5hfjA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ica | PERIODIC TRYPTOPHANPROTEIN 2-LIKEPROTEINPUTATIVE U3 SNORNPPROTEIN (Chaetomiumthermophilum) |
PF04003(Utp12)PF04192(Utp21) | 3 | ILE D 830MET C 995ASP D 835 | None | 0.62A | 5h2uA-5icaD:undetectable | 5h2uA-5icaD:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kc9 | GLUTAMATE RECEPTORIONOTROPIC, DELTA-1 (Mus musculus) |
PF01094(ANF_receptor) | 3 | ILE A 262MET A 315ASP A 264 | NoneNoneEDO A 503 ( 3.8A) | 0.78A | 5h2uA-5kc9A:undetectable | 5h2uA-5kc9A:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kel | C2G4 VARIABLE FABDOMAIN HEAVY CHAINC2G4 VARIABLE FABDOMAIN LIGHT CHAIN (Homo sapiens) |
PF07686(V-set) | 3 | ILE L 53MET H 100ASP L 56 | None | 0.68A | 5h2uA-5kelL:undetectable | 5h2uA-5kelL:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lad | PUTATIVE GTP-BINDINGPROTEIN (Thermotogamaritima) |
PF01926(MMR_HSR1) | 3 | ILE A 244MET A 238ASP A 183 | None | 0.79A | 5h2uA-5ladA:undetectable | 5h2uA-5ladA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5med | ARACHIDONATE15-LIPOXYGENASE (Cyanothece sp.PCC 8801) |
PF00305(Lipoxygenase) | 3 | ILE A 353MET A 119ASP A 371 | None | 0.73A | 5h2uA-5medA:undetectable | 5h2uA-5medA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uak | CYSTIC FIBROSISTRANSMEMBRANECONDUCTANCEREGULATOR (Homo sapiens) |
PF00005(ABC_tran)PF00664(ABC_membrane)PF14396(CFTR_R) | 3 | ILE A 255MET A 245ASP A 985 | None | 0.71A | 5h2uA-5uakA:undetectable | 5h2uA-5uakA:10.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5urp | TOXIN 2A (Paenibacilluslarvae) |
no annotation | 3 | ILE A 6MET A 169ASP A 3 | None | 0.77A | 5h2uA-5urpA:undetectable | 5h2uA-5urpA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wru | PROBABLE INORGANICPYROPHOSPHATASE (Plasmodiumfalciparum) |
no annotation | 3 | ILE A 65MET A 81ASP A 67 | None | 0.82A | 5h2uA-5wruA:undetectable | 5h2uA-5wruA:18.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xmj | FUMARATE REDUCTASEFLAVOPROTEIN SUBUNIT (Desulfovibriogigas) |
no annotation | 3 | ILE A 88MET A 590ASP A 82 | None | 0.77A | 5h2uA-5xmjA:undetectable | 5h2uA-5xmjA:12.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y4k | DMSP LYASE DDDY (Acinetobacterbereziniae) |
no annotation | 3 | ILE A 192MET A 272ASP A 189 | None | 0.77A | 5h2uA-5y4kA:undetectable | 5h2uA-5y4kA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6az0 | MITOCHONDRIAL INNERMEMBRANE I-AAAPROTEASESUPERCOMPLEX SUBUNITYME1 (Saccharomycescerevisiae) |
no annotation | 3 | ILE A 664MET A 635ASP A 669 | None | 0.77A | 5h2uA-6az0A:undetectable | 5h2uA-6az0A:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b7k | ENDO-ALPHA-(1->5)-L-ARABINANASE (Bacilluslicheniformis) |
no annotation | 3 | ILE A 186MET A 162ASP A 136 | None | 0.76A | 5h2uA-6b7kA:undetectable | 5h2uA-6b7kA:14.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fml | IES6 (Chaetomiumthermophilum) |
no annotation | 3 | ILE I 193MET I 204ASP I 171 | None | 0.79A | 5h2uA-6fmlI:undetectable | 5h2uA-6fmlI:14.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gsw | MU CLASS GLUTATHIONES-TRANSFERASE OFISOENZYME 3-3 (Rattus rattus) |
PF00043(GST_C)PF02798(GST_N) | 3 | ILE A 207MET A 197ASP A 161 | None | 0.81A | 5h2uA-6gswA:undetectable | 5h2uA-6gswA:21.45 |