SIMILAR PATTERNS OF AMINO ACIDS FOR 5H1E_A_VDXA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		5 LEU A 552
ILE A 399
SER A 398
VAL A 547
HIS A 546
 None
 1.43A 5h1eA-1cjyA:
0.0		 5h1eA-1cjyA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnr TUMOR NECROSIS
FACTOR BETA

(Homo sapiens) 		PF00229
(TNF) 		5 LEU A  33
SER A  64
VAL A  75
HIS A 135
HIS A  99
 None
 1.23A 5h1eA-1tnrA:
undetectable		 5h1eA-1tnrA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		5 LEU A 377
SER A 654
TRP A 637
VAL A 531
HIS A 530
 None
None
None
None
CU  A 801 (-3.2A)
 1.48A 5h1eA-1w7cA:
0.0		 5h1eA-1w7cA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xuv HYPOTHETICAL PROTEIN
MM0500

(Methanosarcina
mazei) 		PF08327
(AHSA1) 		5 PHE A  41
LEU A 130
SER A 132
ILE A  26
SER A 157
 None
 1.22A 5h1eA-1xuvA:
undetectable		 5h1eA-1xuvA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa1 HEMOGLOBIN BETA-C
CHAIN

(Trematomus
newnesi) 		PF00042
(Globin) 		5 PHE B  15
LEU B  71
ILE B  67
VAL B 138
HIS B  92
 None
HEM  B 400 ( 4.8A)
HEM  B 400 (-4.1A)
None
HEM  B 400 (-3.4A)
 1.21A 5h1eA-2aa1B:
undetectable		 5h1eA-2aa1B:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7v TRANSMEMBRANE
PROTEASE

(Mus musculus) 		PF01390
(SEA) 		5 LEU A  93
SER A  91
ARG A 141
SER A 137
VAL A 130
 None
 1.43A 5h1eA-2e7vA:
0.0		 5h1eA-2e7vA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k1g LIPOPROTEIN SPR

(Escherichia
coli) 		PF00877
(NLPC_P60) 		5 SER A  61
ARG A  86
VAL A 130
HIS A 131
HIS A 119
 None
 1.42A 5h1eA-2k1gA:
0.0		 5h1eA-2k1gA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN

(Bacillus
megaterium) 		PF13377
(Peripla_BP_3) 		5 TYR G 161
PHE G  74
LEU G  78
SER G 147
VAL G  65
 None
BG6  G1092 (-3.3A)
None
None
None
 1.43A 5h1eA-2nzuG:
0.0		 5h1eA-2nzuG:
22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		8 PHE A 153
LEU A 229
SER A 233
ILE A 267
ARG A 270
VAL A 296
HIS A 301
HIS A 393
 None
VD4  A 500 ( 4.8A)
VD4  A 500 ( 2.8A)
VD4  A 500 ( 4.7A)
VD4  A 500 ( 4.0A)
VD4  A 500 ( 4.4A)
VD4  A 500 ( 3.9A)
VD4  A 500 ( 3.9A)
 1.34A 5h1eA-2o4jA:
39.6		 5h1eA-2o4jA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		12 TYR A 143
PHE A 150
LEU A 229
SER A 233
ILE A 267
ARG A 270
SER A 271
SER A 274
TRP A 282
VAL A 296
HIS A 301
HIS A 393
 VD4  A 500 ( 4.7A)
None
VD4  A 500 ( 4.8A)
VD4  A 500 ( 2.8A)
VD4  A 500 ( 4.7A)
VD4  A 500 ( 4.0A)
VD4  A 500 ( 3.9A)
VD4  A 500 ( 2.9A)
VD4  A 500 ( 3.7A)
VD4  A 500 ( 4.4A)
VD4  A 500 ( 3.9A)
VD4  A 500 ( 3.9A)
 0.27A 5h1eA-2o4jA:
39.6		 5h1eA-2o4jA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		7 TYR A 143
PHE A 150
LEU A 229
SER A 271
SER A 274
TRP A 282
HIS A 301
 VD4  A 500 ( 4.7A)
None
VD4  A 500 ( 4.8A)
VD4  A 500 ( 3.9A)
VD4  A 500 ( 2.9A)
VD4  A 500 ( 3.7A)
VD4  A 500 ( 3.9A)
 1.21A 5h1eA-2o4jA:
39.6		 5h1eA-2o4jA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zae RIBONUCLEASE P
PROTEIN COMPONENT 1

(Pyrococcus
horikoshii) 		PF01868
(UPF0086) 		5 LEU A 112
ILE A  43
ARG A  40
VAL A  70
HIS A  34
 None
 1.28A 5h1eA-2zaeA:
0.0		 5h1eA-2zaeA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 SER A 272
SER A 231
SER A 198
HIS A 136
HIS A 134
 None
None
None
CU  A 701 (-3.2A)
CU  A 702 (-3.1A)
 1.35A 5h1eA-3abgA:
undetectable		 5h1eA-3abgA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akc CYTIDYLATE KINASE

(Thermus
thermophilus) 		PF02224
(Cytidylate_kin) 		5 TYR A 141
SER A  13
SER A 179
VAL A  97
HIS A  89
 None
ADP  A 210 (-3.5A)
None
CDP  A 209 (-4.3A)
None
 1.45A 5h1eA-3akcA:
undetectable		 5h1eA-3akcA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b46 AMINOTRANSFERASE
BNA3

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		5 LEU A  97
SER A 100
ILE A 317
SER A 316
HIS A 242
 None
 1.34A 5h1eA-3b46A:
undetectable		 5h1eA-3b46A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		5 PHE A 286
ILE A  85
SER A  78
VAL A 278
HIS A  63
 None
None
None
None
FE  A 502 (-3.1A)
 1.17A 5h1eA-3g77A:
undetectable		 5h1eA-3g77A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4t DIPHTHINE SYNTHASE

(Entamoeba
histolytica) 		PF00590
(TP_methylase) 		5 PHE A 127
LEU A 249
SER A 120
ILE A 228
HIS A 246
 None
 1.49A 5h1eA-3i4tA:
undetectable		 5h1eA-3i4tA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128

(Homo sapiens) 		PF02225
(PA) 		5 PHE A 146
LEU A 119
ILE A 183
SER A 182
VAL A  49
 None
 1.49A 5h1eA-3icuA:
undetectable		 5h1eA-3icuA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loy COPPER AMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid) 		5 PHE A 442
LEU A 440
VAL A 286
HIS A 436
HIS A 597
 None
None
None
CU  A 635 (-3.2A)
CU  A 635 (-3.0A)
 1.50A 5h1eA-3loyA:
undetectable		 5h1eA-3loyA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A

(Bacillus
subtilis) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		5 TYR A 162
PHE A  75
LEU A  79
SER A 148
VAL A  66
 None
 1.47A 5h1eA-3oqnA:
undetectable		 5h1eA-3oqnA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5m ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 PHE A  59
LEU A  52
ILE A  38
VAL A   6
HIS A   8
 None
None
None
EDO  A 252 (-4.3A)
None
 1.41A 5h1eA-3p5mA:
undetectable		 5h1eA-3p5mA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF06824
(Glyco_hydro_125) 		5 PHE A 287
LEU A 226
SER A 229
SER A 217
HIS A 177
 None
 1.35A 5h1eA-3qpfA:
undetectable		 5h1eA-3qpfA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpx FAB C2507 HEAVY
CHAIN
FAB C2507 LIGHT
CHAIN

(Homo sapiens;
Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 PHE L 117
LEU L 134
SER H 138
VAL L 195
HIS L 197
 None
 1.36A 5h1eA-3qpxL:
undetectable		 5h1eA-3qpxL:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6g SH2
DOMAIN-CONTAINING
PROTEIN 3C

(Homo sapiens) 		PF00617
(RasGEF) 		5 LEU A 495
SER A 691
ARG A 542
SER A 541
HIS A 484
 None
 1.33A 5h1eA-3t6gA:
undetectable		 5h1eA-3t6gA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thw DNA MISMATCH REPAIR
PROTEIN MSH3

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05192
(MutS_III) 		5 LEU B 567
ILE B 909
ARG B 584
SER B 911
VAL B 554
 None
 1.43A 5h1eA-3thwB:
undetectable		 5h1eA-3thwB:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9j F-BOX/LRR-REPEAT
PROTEIN 5

(Homo sapiens) 		PF01814
(Hemerythrin) 		5 PHE A 142
ILE A  66
SER A  73
VAL A 133
HIS A 126
 None
None
None
None
FE  A 200 (-3.5A)
 1.28A 5h1eA-3u9jA:
undetectable		 5h1eA-3u9jA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9j F-BOX/LRR-REPEAT
PROTEIN 5

(Homo sapiens) 		PF01814
(Hemerythrin) 		5 PHE A 142
LEU A 138
ILE A  66
SER A  73
VAL A 133
 None
 1.45A 5h1eA-3u9jA:
undetectable		 5h1eA-3u9jA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uca GERANYLTRANSTRANSFER
ASE

(Clostridium
perfringens) 		PF00348
(polyprenyl_synt) 		5 PHE A 216
LEU A 220
ILE A  54
SER A  62
HIS A  84
 None
 1.46A 5h1eA-3ucaA:
undetectable		 5h1eA-3ucaA:
22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 PHE A 153
LEU A 233
SER A 237
ILE A 271
ARG A 274
HIS A 305
HIS A 397
 None
ED9  A 501 ( 4.3A)
ED9  A 501 (-2.7A)
ED9  A 501 (-4.5A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.9A)
ED9  A 501 (-3.9A)
 1.37A 5h1eA-3wgpA:
37.4		 5h1eA-3wgpA:
90.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 TYR A 143
PHE A 150
LEU A 233
SER A 237
ILE A 271
ARG A 274
SER A 275
SER A 278
TRP A 286
VAL A 300
HIS A 305
HIS A 397
 ED9  A 501 (-3.7A)
None
ED9  A 501 ( 4.3A)
ED9  A 501 (-2.7A)
ED9  A 501 (-4.5A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.5A)
ED9  A 501 (-4.5A)
ED9  A 501 (-3.9A)
ED9  A 501 (-3.9A)
 0.32A 5h1eA-3wgpA:
37.4		 5h1eA-3wgpA:
90.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 TYR A 143
PHE A 150
LEU A 233
SER A 275
SER A 278
TRP A 286
HIS A 305
 ED9  A 501 (-3.7A)
None
ED9  A 501 ( 4.3A)
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.5A)
ED9  A 501 (-3.9A)
 1.19A 5h1eA-3wgpA:
37.4		 5h1eA-3wgpA:
90.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

([Eubacterium]
eligens) 		PF01497
(Peripla_BP_2) 		5 TYR A  80
SER A  84
ILE A 107
TRP A 309
VAL A 341
 None
 1.22A 5h1eA-4hn9A:
undetectable		 5h1eA-4hn9A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i84 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 PHE A 267
LEU A 246
ILE A 211
SER A 257
VAL A 200
 None
 1.43A 5h1eA-4i84A:
undetectable		 5h1eA-4i84A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9u L-LACTATE
DEHYDROGENASE A
CHAIN

(Oryctolagus
cuniculus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 PHE A 152
LEU A 132
SER A  88
SER A 127
VAL A  25
 None
None
None
None
1E7  A 401 (-4.5A)
 1.43A 5h1eA-4i9uA:
undetectable		 5h1eA-4i9uA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rld ASPARTIC PROTEASE
BLA G 2

(Blattella
germanica) 		PF00026
(Asp) 		5 PHE A 151
SER A  33
ILE A 213
SER A 189
VAL A 182
 None
 1.42A 5h1eA-4rldA:
undetectable		 5h1eA-4rldA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 PHE A 269
LEU A 248
ILE A 213
SER A 259
VAL A 202
 None
 1.46A 5h1eA-4rt6A:
undetectable		 5h1eA-4rt6A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upe NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
fructosivorans) 		PF00374
(NiFeSe_Hases) 		5 PHE Q 390
LEU Q 386
SER Q 420
HIS Q 118
HIS Q 123
 None
 1.21A 5h1eA-4upeQ:
undetectable		 5h1eA-4upeQ:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmp HEAVY CHAIN OF
ANTIBODY VRC08
LIGHT CHAIN OF
ANTIBODY VRC08

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 PHE L 118
LEU L 135
SER H 132
VAL L 196
HIS L 198
 None
 1.48A 5h1eA-4xmpL:
undetectable		 5h1eA-4xmpL:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 LEU A1262
SER A1265
ILE A1195
VAL A1099
HIS A1042
 None
 1.43A 5h1eA-5epgA:
undetectable		 5h1eA-5epgA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 5 LEU A 415
ILE A 474
SER A 475
SER A 336
VAL A 425
 None
 1.50A 5h1eA-5nitA:
undetectable		 5h1eA-5nitA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3p DH511.4 FAB HEAVY
CHAIN
DH511.4 FAB LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 PHE L 118
LEU L 135
SER H 132
VAL L 196
HIS L 198
 None
 1.38A 5h1eA-5u3pL:
undetectable		 5h1eA-5u3pL:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucy TUBULIN ALPHA CHAIN

(Tetrahymena
thermophila) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 TYR A 272
LEU A  23
SER A 236
ILE A 235
HIS A   8
 None
 1.32A 5h1eA-5ucyA:
undetectable		 5h1eA-5ucyA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		PF13281
(DUF4071) 		5 LEU A 333
ILE A 313
SER A 320
VAL A 351
HIS A 348
 None
 1.37A 5h1eA-5ulmA:
undetectable		 5h1eA-5ulmA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1

(Streptococcus
gordonii) 		no annotation 5 TYR A 462
PHE A  32
SER A 449
ILE A 503
SER A 306
 None
 1.47A 5h1eA-5vaeA:
undetectable		 5h1eA-5vaeA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A 246
ILE A 254
SER A 229
HIS A 224
HIS A 222
 None
 1.18A 5h1eA-5vywA:
undetectable		 5h1eA-5vywA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 5 PHE A 277
LEU A 281
ILE A1229
SER A 442
HIS A1138
 None
 1.35A 5h1eA-5wlhA:
undetectable		 5h1eA-5wlhA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 5 TYR A 981
LEU A 569
SER A 568
SER A 976
VAL A 634
 None
 1.39A 5h1eA-5wlhA:
undetectable		 5h1eA-5wlhA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 8 PHE A 185
LEU A 261
SER A 265
ILE A 299
ARG A 302
VAL A 328
HIS A 333
HIS A 423
 None
DZW  A 501 ( 4.5A)
DZW  A 501 (-3.0A)
DZW  A 501 (-4.7A)
DZW  A 501 (-3.8A)
DZW  A 501 ( 4.3A)
DZW  A 501 (-3.9A)
DZW  A 501 (-4.0A)
 1.29A 5h1eA-6fobA:
38.0		 5h1eA-6fobA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 12 TYR A 175
PHE A 182
LEU A 261
SER A 265
ILE A 299
ARG A 302
SER A 303
SER A 306
TRP A 314
VAL A 328
HIS A 333
HIS A 423
 None
None
DZW  A 501 ( 4.5A)
DZW  A 501 (-3.0A)
DZW  A 501 (-4.7A)
DZW  A 501 (-3.8A)
DZW  A 501 (-3.8A)
DZW  A 501 (-2.7A)
DZW  A 501 (-3.5A)
DZW  A 501 ( 4.3A)
DZW  A 501 (-3.9A)
DZW  A 501 (-4.0A)
 0.34A 5h1eA-6fobA:
38.0		 5h1eA-6fobA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 7 TYR A 175
PHE A 182
LEU A 261
SER A 303
SER A 306
TRP A 314
HIS A 333
 None
None
DZW  A 501 ( 4.5A)
DZW  A 501 (-3.8A)
DZW  A 501 (-2.7A)
DZW  A 501 (-3.5A)
DZW  A 501 (-3.9A)
 1.15A 5h1eA-6fobA:
38.0		 5h1eA-6fobA:
21.78