SIMILAR PATTERNS OF AMINO ACIDS FOR 5GWZ_D_010D6

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1byo PROTEIN
(PLASTOCYANIN)

(Silene
latifolia) 		PF00127
(Copper-bind) 		3 MET A  92
HIS A  37
GLY A  11
 CU  A 100 ( 2.7A)
CU  A 100 ( 3.1A)
None
 0.69A 5gwzB-1byoA:
undetectable		 5gwzB-1byoA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 MET A1451
HIS A1504
GLY A1462
 None
 0.80A 5gwzB-1e6yA:
0.0		 5gwzB-1e6yA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuz PLASTOCYANIN

(Ulva pertusa) 		PF00127
(Copper-bind) 		3 MET A  92
HIS A  37
GLY A   7
 CU  A 100 ( 2.6A)
CU  A 100 ( 3.2A)
None
 0.87A 5gwzB-1iuzA:
0.0		 5gwzB-1iuzA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js1 TRANSCARBAMYLASE

(Bacteroides
fragilis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 MET X  85
HIS X  92
GLY X  82
 None
 0.78A 5gwzB-1js1X:
0.0		 5gwzB-1js1X:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 MET A 968
HIS A 818
GLY A 638
 None
 0.79A 5gwzB-1kcwA:
0.0		 5gwzB-1kcwA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE

(Methylobacterium
extorquens) 		PF09176
(Mpt_N) 		3 MET A  93
HIS A 260
GLY A  66
 None
 0.70A 5gwzB-1luaA:
0.8		 5gwzB-1luaA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 MET A 431
HIS A 484
GLY A 442
 None
 0.81A 5gwzB-1mroA:
0.0		 5gwzB-1mroA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE
METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis;
Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		3 MET A 367
HIS C 238
GLY A 423
 None
 0.78A 5gwzB-1mroA:
0.0		 5gwzB-1mroA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 MET A 405
HIS A 415
GLY A 611
 None
 0.73A 5gwzB-1ogyA:
0.4		 5gwzB-1ogyA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1plb PLASTOCYANIN

(Petroselinum
crispum) 		PF00127
(Copper-bind) 		3 MET A  90
HIS A  37
GLY A  11
 CU  A 100 (-3.1A)
CU  A 100 ( 3.2A)
None
 0.45A 5gwzB-1plbA:
undetectable		 5gwzB-1plbA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdb CYTOCHROME C NITRITE
REDUCTASE

(Sulfurospirillum
deleyianum) 		PF02335
(Cytochrom_C552) 		3 MET A 277
HIS A 369
GLY A 395
 None
 0.86A 5gwzB-1qdbA:
undetectable		 5gwzB-1qdbA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s6d ALBUMIN 8

(Helianthus
annuus) 		PF00234
(Tryp_alpha_amyl) 		3 MET A  97
HIS A  88
GLY A   3
 None
 0.64A 5gwzB-1s6dA:
undetectable		 5gwzB-1s6dA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuf DIAMINOPIMELATE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 MET A 341
HIS A 351
GLY A 399
 None
 0.83A 5gwzB-1tufA:
undetectable		 5gwzB-1tufA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 MET A  49
HIS A  65
GLY A  44
 None
ZN  A 401 (-3.4A)
None
 0.84A 5gwzB-1vj0A:
undetectable		 5gwzB-1vj0A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkg MAJOR MITE FECAL
ALLERGEN DER P 1

(Dermatophagoides
pteronyssinus) 		PF00112
(Peptidase_C1) 		3 MET A 107
HIS A  48
GLY A 280
 None
 0.85A 5gwzB-1xkgA:
undetectable		 5gwzB-1xkgA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		3 MET A 106
HIS A  16
GLY A 361
 None
None
SUG  A1001 ( 4.2A)
 0.77A 5gwzB-1yniA:
undetectable		 5gwzB-1yniA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c41 DPS FAMILY
DNA-BINDING STRESS
RESPONSE PROTEIN

(Thermosynechococcus
elongatus) 		PF00210
(Ferritin) 		3 MET A  25
HIS A 106
GLY A  52
 None
 0.73A 5gwzB-2c41A:
undetectable		 5gwzB-2c41A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2can ORNITHINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00202
(Aminotran_3) 		3 MET A 139
HIS A 319
GLY A 146
 None
 0.68A 5gwzB-2canA:
undetectable		 5gwzB-2canA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		3 MET A 185
HIS A 294
GLY A 209
 None
 0.86A 5gwzB-2ctzA:
undetectable		 5gwzB-2ctzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cun PHOSPHOGLYCERATE
KINASE

(Pyrococcus
horikoshii) 		PF00162
(PGK) 		3 MET A  24
HIS A  72
GLY A  59
 None
 0.84A 5gwzB-2cunA:
undetectable		 5gwzB-2cunA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		3 MET A 550
HIS A 515
GLY A 484
 None
 0.79A 5gwzB-2e0wA:
undetectable		 5gwzB-2e0wA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		3 MET B 550
HIS B 515
GLY B 484
 None
 0.77A 5gwzB-2e0xB:
undetectable		 5gwzB-2e0xB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gop TRILOBED PROTEASE

(Pyrococcus
furiosus) 		PF07676
(PD40) 		3 MET A 213
HIS A 179
GLY A 251
 None
 0.88A 5gwzB-2gopA:
undetectable		 5gwzB-2gopA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		3 MET A 260
HIS A 214
GLY A 364
 None
ZN  A1001 (-3.2A)
None
 0.85A 5gwzB-2gsnA:
undetectable		 5gwzB-2gsnA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h12 CITRATE SYNTHASE

(Acetobacter
aceti) 		PF00285
(Citrate_synt) 		3 MET A 326
HIS A 234
GLY A 375
 None
 0.83A 5gwzB-2h12A:
undetectable		 5gwzB-2h12A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Arabidopsis
thaliana) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 MET A 222
HIS A 203
GLY A 217
 None
 0.73A 5gwzB-2ix4A:
undetectable		 5gwzB-2ix4A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p17 PIRIN-LIKE PROTEIN

(Geobacillus
kaustophilus) 		PF02678
(Pirin)
PF05726
(Pirin_C) 		3 MET A  15
HIS A 110
GLY A 211
 None
 0.67A 5gwzB-2p17A:
undetectable		 5gwzB-2p17A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm6 GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Helicobacter
pylori) 		PF01019
(G_glu_transpept) 		3 MET B 540
HIS B 504
GLY B 473
 None
None
GLU  B   1 (-3.6A)
 0.80A 5gwzB-2qm6B:
undetectable		 5gwzB-2qm6B:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E

(Bacillus cereus) 		PF04204
(HTS) 		3 MET A  44
HIS A 235
GLY A 144
 HSE  A1298 ( 3.8A)
HSE  A1298 (-3.9A)
None
 0.75A 5gwzB-2vdjA:
undetectable		 5gwzB-2vdjA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 MET A  15
HIS A  55
GLY A 337
 None
 0.82A 5gwzB-2x0nA:
undetectable		 5gwzB-2x0nA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 3 MET A 666
HIS A  33
GLY A 149
 None
 0.81A 5gwzB-2yr5A:
undetectable		 5gwzB-2yr5A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afe HYDROXYLASE,
PUTATIVE

(Mycobacterium
tuberculosis) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 MET A 213
HIS A  95
GLY A 167
 None
 0.68A 5gwzB-3afeA:
undetectable		 5gwzB-3afeA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf5 RIBOKINASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF00294
(PfkB) 		3 MET A 106
HIS A   9
GLY A 109
 None
PGO  A 288 ( 4.9A)
None
 0.86A 5gwzB-3bf5A:
undetectable		 5gwzB-3bf5A:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d23 3C-LIKE PROTEINASE

(Human
coronavirus
HKU1) 		no annotation 3 MET B  25
HIS B  41
GLY B 143
 None
 0.44A 5gwzB-3d23B:
19.9		 5gwzB-3d23B:
44.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 MET A1161
HIS A1243
GLY A1164
 None
 0.83A 5gwzB-3eh1A:
undetectable		 5gwzB-3eh1A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkb PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
avermitilis) 		PF00378
(ECH_1) 		3 MET A 145
HIS A  67
GLY A 254
 None
 0.82A 5gwzB-3gkbA:
undetectable		 5gwzB-3gkbA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihj ALANINE
AMINOTRANSFERASE 2

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		3 MET A 385
HIS A 337
GLY A 345
 None
 0.73A 5gwzB-3ihjA:
undetectable		 5gwzB-3ihjA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4e UNCHARACTERIZED
PEPTIDASE LMO0363

(Listeria
monocytogenes) 		PF03575
(Peptidase_S51) 		3 MET A 135
HIS A 160
GLY A  87
 None
 0.74A 5gwzB-3l4eA:
undetectable		 5gwzB-3l4eA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 MET A 303
HIS A 342
GLY A 253
 None
 0.57A 5gwzB-3lkdA:
undetectable		 5gwzB-3lkdA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mr1 METHIONINE
AMINOPEPTIDASE

(Rickettsia
prowazekii) 		PF00557
(Peptidase_M24) 		3 MET A 203
HIS A  77
GLY A 167
 None
PO4  A 252 (-4.2A)
None
 0.86A 5gwzB-3mr1A:
undetectable		 5gwzB-3mr1A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qil CLATHRIN HEAVY CHAIN
1

(Bos taurus) 		PF00637
(Clathrin) 		3 MET A1520
HIS A1505
GLY A1517
 None
 0.84A 5gwzB-3qilA:
undetectable		 5gwzB-3qilA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7w GTP-BINDING PROTEIN
GTR1

(Saccharomyces
cerevisiae) 		PF04670
(Gtr1_RagA) 		3 MET A 282
HIS A 189
GLY A  53
 None
 0.82A 5gwzB-3r7wA:
undetectable		 5gwzB-3r7wA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT

(uncultured
archaeon) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 MET A 450
HIS A 503
GLY A 461
 None
 0.80A 5gwzB-3sqgA:
undetectable		 5gwzB-3sqgA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		3 MET A 549
HIS A 860
GLY A 587
 None
 0.88A 5gwzB-3ux8A:
undetectable		 5gwzB-3ux8A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		3 MET A 345
HIS A 460
GLY A 335
 None
NDG  A4001 ( 4.0A)
None
 0.85A 5gwzB-3wfzA:
undetectable		 5gwzB-3wfzA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxx ACRH
AOPB

(Aeromonas
hydrophila;
Aeromonas
hydrophila) 		no annotation
PF04888
(SseC) 		3 MET B 204
HIS A  54
GLY B 196
 None
 0.69A 5gwzB-3wxxB:
undetectable		 5gwzB-3wxxB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aah METHANOL
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF13360
(PQQ_2) 		3 MET A 525
HIS A  68
GLY A  53
 None
 0.87A 5gwzB-4aahA:
undetectable		 5gwzB-4aahA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 MET A 502
HIS A 419
GLY A 376
 CU  A 601 (-3.2A)
CU  A 601 (-3.1A)
None
 0.85A 5gwzB-4akoA:
undetectable		 5gwzB-4akoA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ays AMYLOSUCRASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase) 		3 MET A 543
HIS A 475
GLY A 490
 None
 0.66A 5gwzB-4aysA:
undetectable		 5gwzB-4aysA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvl PHB DEPOLYMERASE
PHAZ7

(Paucimonas
lemoignei) 		PF01674
(Lipase_2) 		3 MET A 221
HIS A 106
GLY A 163
 None
 0.81A 5gwzB-4bvlA:
undetectable		 5gwzB-4bvlA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvl PHB DEPOLYMERASE
PHAZ7

(Paucimonas
lemoignei) 		PF01674
(Lipase_2) 		3 MET A 221
HIS A 106
GLY A 167
 None
 0.88A 5gwzB-4bvlA:
undetectable		 5gwzB-4bvlA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190
DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA43

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF03876
(SHS2_Rpb7-N) 		3 MET G  52
HIS A 571
GLY G  60
 None
 0.59A 5gwzB-4c3hG:
undetectable		 5gwzB-4c3hG:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6y CITRATE SYNTHASE

(Vibrio
vulnificus) 		PF00285
(Citrate_synt) 		3 MET A 319
HIS A 227
GLY A 367
 None
 0.87A 5gwzB-4e6yA:
undetectable		 5gwzB-4e6yA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehc PE-PGRS FAMILY
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 3 MET A 187
HIS A -16
GLY A 119
 None
ZN  A 301 ( 3.2A)
None
 0.80A 5gwzB-4ehcA:
1.7		 5gwzB-4ehcA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f41 PROTELOMERASE

(Agrobacterium
fabrum) 		PF16684
(Telomere_res) 		3 MET A 150
HIS A 188
GLY A 143
 None
 0.84A 5gwzB-4f41A:
undetectable		 5gwzB-4f41A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha6 PYRIDOXINE 4-OXIDASE

(Mesorhizobium
loti) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 MET A 333
HIS A 460
GLY A 107
 None
PXM  A 609 (-3.8A)
FAD  A 601 (-3.4A)
 0.84A 5gwzB-4ha6A:
undetectable		 5gwzB-4ha6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 MET A 193
HIS A  40
GLY A  52
 None
 0.82A 5gwzB-4jb6A:
undetectable		 5gwzB-4jb6A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzy CRYPTOCHROME-1

(Drosophila
melanogaster) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 MET A 215
HIS A 403
GLY A 356
 None
 0.88A 5gwzB-4jzyA:
undetectable		 5gwzB-4jzyA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4km3 METHIONINE
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF00557
(Peptidase_M24) 		3 MET A 161
HIS A 265
GLY A 284
 None
 0.71A 5gwzB-4km3A:
undetectable		 5gwzB-4km3A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kp2 HOMOACONITASE LARGE
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		3 MET A  30
HIS A  99
GLY A 132
 None
 0.63A 5gwzB-4kp2A:
undetectable		 5gwzB-4kp2A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III

(Scadoxus
multiflorus) 		PF00704
(Glyco_hydro_18) 		3 MET A 228
HIS A 236
GLY A 191
 None
 0.82A 5gwzB-4n42A:
undetectable		 5gwzB-4n42A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		3 MET B 599
HIS B 524
GLY B 594
 None
 0.84A 5gwzB-4ni2B:
undetectable		 5gwzB-4ni2B:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqy ISOPROPYLMALATE/CITR
AMALATE ISOMERASE
LARGE SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		3 MET A  33
HIS A 103
GLY A 137
 None
 0.83A 5gwzB-4nqyA:
0.1		 5gwzB-4nqyA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb9 ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycolicibacterium
smegmatis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		3 MET A 297
HIS A 105
GLY A 130
 None
 0.77A 5gwzB-4qb9A:
undetectable		 5gwzB-4qb9A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 MET A2816
HIS A2859
GLY A2810
 None
 0.84A 5gwzB-4rh7A:
undetectable		 5gwzB-4rh7A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)

(Bacillus
halodurans) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		3 MET A 220
HIS A 188
GLY A 182
 None
 0.81A 5gwzB-4v2xA:
undetectable		 5gwzB-4v2xA:
21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yog 3C-LIKE PROTEINASE

(Tylonycteris
bat coronavirus
HKU4) 		PF05409
(Peptidase_C30) 		3 MET A  25
HIS A  41
GLY A 146
 4F5  A 405 (-3.4A)
4F5  A 405 (-3.6A)
None
 0.86A 5gwzB-4yogA:
40.4		 5gwzB-4yogA:
47.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE

(Toxoplasma
gondii) 		PF00202
(Aminotran_3) 		3 MET A 133
HIS A 313
GLY A 140
 None
 0.75A 5gwzB-4zlvA:
undetectable		 5gwzB-4zlvA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztc AMINOTRANSFERASE
HOMOLOG

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		3 MET A 138
HIS A 130
GLY A 173
 None
 0.86A 5gwzB-4ztcA:
undetectable		 5gwzB-4ztcA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpk GAMMA-GLUTAMYLTRANSP
EPTIDASE (GGT)

(Helicobacter
pylori) 		PF01019
(G_glu_transpept) 		3 MET C 540
HIS C 504
GLY C 473
 None
None
4UD  C 701 (-3.5A)
 0.83A 5gwzB-5bpkC:
undetectable		 5gwzB-5bpkC:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ekz TRANSLATIONAL
ACTIVATOR OF
CYTOCHROME C OXIDASE
1

(Mus musculus) 		PF01709
(Transcrip_reg) 		3 MET A 172
HIS A 158
GLY A 175
 None
 0.85A 5gwzB-5ekzA:
undetectable		 5gwzB-5ekzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7r LMO0178 PROTEIN

(Listeria
monocytogenes) 		no annotation 3 MET E 264
HIS E 255
GLY E 243
 None
None
GLC  E 501 ( 4.5A)
 0.79A 5gwzB-5f7rE:
undetectable		 5gwzB-5f7rE:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghe PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 3 MET A 303
HIS A  67
GLY A 261
 None
 0.75A 5gwzB-5gheA:
undetectable		 5gwzB-5gheA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gri ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		PF00180
(Iso_dh) 		3 MET A  66
HIS A 290
GLY A 252
 None
 0.80A 5gwzB-5griA:
undetectable		 5gwzB-5griA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7w VENOM
5'-NUCLEOTIDASE

(Naja atra) 		no annotation 3 MET A 511
HIS A 438
GLY A 506
 None
 0.80A 5gwzB-5h7wA:
undetectable		 5gwzB-5h7wA:
20.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hyo PEDV 3CLPRO

(Porcine
epidemic
diarrhea virus) 		PF05409
(Peptidase_C30) 		3 MET A  25
HIS A  41
GLY A 142
 None
 0.62A 5gwzB-5hyoA:
42.4		 5gwzB-5hyoA:
97.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in8 ARISTOLOCHENE
SYNTHASE

(Aspergillus
terreus) 		no annotation 3 MET A 296
HIS A 268
GLY A 291
 None
 0.84A 5gwzB-5in8A:
0.2		 5gwzB-5in8A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE

(Shewanella
oneidensis) 		PF01041
(DegT_DnrJ_EryC1) 		3 MET A 140
HIS A 132
GLY A 175
 None
 0.73A 5gwzB-5k8bA:
undetectable		 5gwzB-5k8bA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh0 SMALL GTP-BINDING
PROTEIN

(Thermosipho
melanesiensis) 		PF01926
(MMR_HSR1) 		3 MET A 354
HIS A 348
GLY A 331
 None
 0.83A 5gwzB-5kh0A:
undetectable		 5gwzB-5kh0A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 3 MET A 303
HIS A  67
GLY A 261
 None
 0.81A 5gwzB-5kucA:
undetectable		 5gwzB-5kucA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 3 MET A 962
HIS A 812
GLY A 632
 None
 0.77A 5gwzB-5n4lA:
undetectable		 5gwzB-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd4 TUBULIN ALPHA CHAIN

(Bos taurus) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		3 MET A 313
HIS A 266
GLY A 436
 None
 0.84A 5gwzB-5nd4A:
undetectable		 5gwzB-5nd4A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A

(Methanothermococcus
thermolithotrophicus) 		PF00374
(NiFeSe_Hases) 		3 MET F  95
HIS F  69
GLY F 159
 None
 0.87A 5gwzB-5odrF:
undetectable		 5gwzB-5odrF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 MET A 295
HIS A 475
GLY A 367
 EST  A 601 ( 4.4A)
EST  A 601 (-4.4A)
None
 0.86A 5gwzB-5toaA:
undetectable		 5gwzB-5toaA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		3 MET A 138
HIS A 130
GLY A 173
 None
 0.85A 5gwzB-5u24A:
undetectable		 5gwzB-5u24A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7

(Homo sapiens) 		PF01663
(Phosphodiest) 		3 MET A  74
HIS A  95
GLY A 281
 IOD  A 532 ( 4.6A)
None
None
 0.63A 5gwzB-5udyA:
undetectable		 5gwzB-5udyA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'

(Mycobacterium
tuberculosis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 MET D 983
HIS D1150
GLY D 980
 None
 0.87A 5gwzB-5uheD:
undetectable		 5gwzB-5uheD:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Listeria
monocytogenes) 		PF00478
(IMPDH) 		3 MET A 391
HIS A  73
GLY A 400
 None
 0.85A 5gwzB-5upyA:
undetectable		 5gwzB-5upyA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		3 MET A 297
HIS A 200
GLY A 160
 None
 0.79A 5gwzB-5w1uA:
undetectable		 5gwzB-5w1uA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF00374
(NiFeSe_Hases) 		3 MET D 115
HIS D  88
GLY D 179
 None
 0.80A 5gwzB-5xfaD:
undetectable		 5gwzB-5xfaD:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 3 MET A 281
HIS A 158
GLY A 611
 None
 0.79A 5gwzB-5xyaA:
undetectable		 5gwzB-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4f ANKYRIN-2

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		3 MET A 838
HIS A 666
GLY A 694
 None
 0.75A 5gwzB-5y4fA:
undetectable		 5gwzB-5y4fA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6t ENDO-1,4-BETA-MANNAN
ASE

(Eisenia fetida) 		no annotation 3 MET A 107
HIS A  83
GLY A 100
 None
 0.62A 5gwzB-5y6tA:
undetectable		 5gwzB-5y6tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b1p GLUTAMATE--TRNA
LIGASE 1

(Helicobacter
pylori) 		PF00749
(tRNA-synt_1c) 		3 MET A 230
HIS A 204
GLY A  19
 None
 0.87A 5gwzB-6b1pA:
undetectable		 5gwzB-6b1pA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b1p GLUTAMATE--TRNA
LIGASE 1

(Helicobacter
pylori) 		PF00749
(tRNA-synt_1c) 		3 MET A 230
HIS A 204
GLY A  20
 None
 0.79A 5gwzB-6b1pA:
undetectable		 5gwzB-6b1pA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2

(Danio rerio) 		no annotation 3 MET A 235
HIS A 266
GLY A 158
 None
 0.82A 5gwzB-6d21A:
undetectable		 5gwzB-6d21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1

(Mus musculus) 		no annotation 3 MET A 203
HIS A 280
GLY A 161
 None
None
PLP  A 601 (-3.7A)
 0.73A 5gwzB-6enzA:
undetectable		 5gwzB-6enzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 3 MET A 376
HIS A 330
GLY A 484
 None
ZN  A1003 (-3.2A)
None
 0.88A 5gwzB-6f2tA:
undetectable		 5gwzB-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 3 MET A 933
HIS A 985
GLY A1198
 None
 0.69A 5gwzB-6fikA:
undetectable		 5gwzB-6fikA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g74 QUINOLINATE SYNTHASE
A

(Thermotoga
maritima) 		no annotation 3 MET A 257
HIS A  19
GLY A 232
 None
PHT  A 302 (-4.0A)
None
 0.86A 5gwzB-6g74A:
undetectable		 5gwzB-6g74A:
undetectable