SIMILAR PATTERNS OF AMINO ACIDS FOR 5GWX_A_SAMA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1civ NADP-MALATE
DEHYDROGENASE

(Flaveria
bidentis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ARG A 136
ASN A 224
ASP A 197
 None
None
NAP  A 386 ( 4.8A)
 0.60A 5gwxA-1civA:
6.2		 5gwxA-1civA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyg CYCLODEXTRIN
GLUCANOTRANSFERASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		3 ARG A 116
ASN A  56
ASP A  24
 None
None
CA  A 682 (-3.2A)
 0.93A 5gwxA-1cygA:
undetectable		 5gwxA-1cygA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 ARG A   8
ASN A 181
ASP A 227
 None
 0.82A 5gwxA-1d6hA:
undetectable		 5gwxA-1d6hA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		3 ARG A 436
ASN A 488
ASP A 574
 None
 0.92A 5gwxA-1d8cA:
undetectable		 5gwxA-1d8cA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		3 ARG A 757
ASN A 655
ASP A 631
 None
 0.89A 5gwxA-1i8qA:
undetectable		 5gwxA-1i8qA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idm 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		3 ARG A  92
ASN A 100
ASP A 243
 None
 0.73A 5gwxA-1idmA:
undetectable		 5gwxA-1idmA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3u ASPARTASE

(Bacillus sp.
YM55-1) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 ARG A 210
ASN A 287
ASP A 294
 None
 0.78A 5gwxA-1j3uA:
undetectable		 5gwxA-1j3uA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmc PROTEIN (REPLICATION
PROTEIN A (RPA))

(Homo sapiens) 		PF01336
(tRNA_anti-codon)
PF16900
(REPA_OB_2) 		3 ARG A 412
ASN A 402
ASP A 369
 None
 0.92A 5gwxA-1jmcA:
undetectable		 5gwxA-1jmcA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		3 ARG A 131
ASN A 340
ASP A 315
 None
 0.57A 5gwxA-1kczA:
undetectable		 5gwxA-1kczA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkr 3-METHYLASPARTATE
AMMONIA-LYASE

(Citrobacter
amalonaticus) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		3 ARG A 131
ASN A 340
ASP A 315
 None
 0.66A 5gwxA-1kkrA:
undetectable		 5gwxA-1kkrA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kob TWITCHIN

(Aplysia
californica) 		PF00069
(Pkinase) 		3 ARG A 355
ASN A 179
ASP A 232
 None
 0.84A 5gwxA-1kobA:
undetectable		 5gwxA-1kobA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		3 ARG A 517
ASN A 541
ASP A 152
 None
 0.92A 5gwxA-1m1cA:
undetectable		 5gwxA-1m1cA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 ARG B 517
ASN B 738
ASP B 731
 None
 0.90A 5gwxA-1m2vB:
undetectable		 5gwxA-1m2vB:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miv TRNA CCA-ADDING
ENZYME

(Geobacillus
stearothermophilus) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd)
PF13735
(tRNA_NucTran2_2) 		3 ARG A 160
ASN A 116
ASP A  42
 None
 0.84A 5gwxA-1mivA:
undetectable		 5gwxA-1mivA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miv TRNA CCA-ADDING
ENZYME

(Geobacillus
stearothermophilus) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd)
PF13735
(tRNA_NucTran2_2) 		3 ARG A 160
ASN A 116
ASP A 107
 None
 0.84A 5gwxA-1mivA:
undetectable		 5gwxA-1mivA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw9 DNA TOPOISOMERASE I

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 ARG X 493
ASN X 548
ASP X 541
 None
 0.78A 5gwxA-1mw9X:
undetectable		 5gwxA-1mw9X:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1noz DNA POLYMERASE

(Escherichia
virus T4) 		PF03104
(DNA_pol_B_exo1) 		3 ARG A 238
ASN A 200
ASP A 193
 None
 0.76A 5gwxA-1nozA:
undetectable		 5gwxA-1nozA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsv GALACTOSE MUTAROTASE

(Lactococcus
lactis) 		PF01263
(Aldose_epim) 		3 ARG A  71
ASN A  96
ASP A  58
 BGC  A1400 (-2.9A)
BGC  A1400 (-2.8A)
None
 0.81A 5gwxA-1nsvA:
undetectable		 5gwxA-1nsvA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 ARG A 517
ASN A 738
ASP A 731
 None
 0.90A 5gwxA-1pd1A:
undetectable		 5gwxA-1pd1A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5n 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Acinetobacter
calcoaceticus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		3 ARG A 176
ASN A 247
ASP A 254
 None
 0.88A 5gwxA-1q5nA:
undetectable		 5gwxA-1q5nA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmv PEROXIREDOXIN-2

(Homo sapiens) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		3 ARG A  91
ASN A 100
ASP A  64
 None
 0.85A 5gwxA-1qmvA:
undetectable		 5gwxA-1qmvA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		3 ARG A  52
ASN A 168
ASP A 161
 None
 0.86A 5gwxA-1upxA:
undetectable		 5gwxA-1upxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0h 3'-5' EXONUCLEASE
ERI1

(Homo sapiens) 		PF00929
(RNase_T) 		3 ARG A 272
ASN A 259
ASP A 134
 None
None
MG  A1000 (-2.0A)
 0.89A 5gwxA-1w0hA:
undetectable		 5gwxA-1w0hA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		3 ARG A 514
ASN A 496
ASP A 339
 None
 0.75A 5gwxA-1xjeA:
undetectable		 5gwxA-1xjeA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1e STILBENE SYNTHASE

(Arachis
hypogaea) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 ARG A   8
ASN A 181
ASP A 227
 None
 0.72A 5gwxA-1z1eA:
undetectable		 5gwxA-1z1eA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		3 ARG A 282
ASN A 210
ASP A 207
 None
 0.61A 5gwxA-2d1gA:
undetectable		 5gwxA-2d1gA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d52 PENTAKETIDE CHROMONE
SYNTHASE

(Aloe
arborescens) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 ARG A  21
ASN A 194
ASP A 240
 None
 0.86A 5gwxA-2d52A:
undetectable		 5gwxA-2d52A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ARG A 492
ASN A  80
ASP A  65
 None
 0.91A 5gwxA-2g5tA:
undetectable		 5gwxA-2g5tA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i39 PROTEIN N1

(Vaccinia virus) 		PF06227
(Poxvirus) 		3 ARG A 100
ASN A  60
ASP A  52
 None
 0.77A 5gwxA-2i39A:
undetectable		 5gwxA-2i39A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 ARG A 861
ASN A 722
ASP A 270
 None
 0.91A 5gwxA-2nz9A:
undetectable		 5gwxA-2nz9A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2z HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF01933
(UPF0052) 		3 ARG A  78
ASN A  92
ASP A  37
 SO4  A 323 (-2.8A)
SO4  A 323 (-3.5A)
None
 0.93A 5gwxA-2o2zA:
4.9		 5gwxA-2o2zA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ARG A 493
ASN A  78
ASP A  63
 None
 0.92A 5gwxA-2oaeA:
undetectable		 5gwxA-2oaeA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogj DIHYDROOROTASE

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		3 ARG A 281
ASN A 249
ASP A 217
 None
 0.85A 5gwxA-2ogjA:
undetectable		 5gwxA-2ogjA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p12 HYPOTHETICAL PROTEIN
DUF402

(Rhodococcus
jostii) 		PF04167
(DUF402) 		3 ARG A  68
ASN A  23
ASP A  50
 None
 0.87A 5gwxA-2p12A:
undetectable		 5gwxA-2p12A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13489
(Methyltransf_23) 		3 ARG A  15
ASN A  43
ASP A  50
 None
 0.89A 5gwxA-2p35A:
17.4		 5gwxA-2p35A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3n AGGLUTININ-1 B CHAIN

(Abrus
precatorius) 		PF00652
(Ricin_B_lectin) 		3 ARG B 220
ASN B 128
ASP B  96
 None
 0.91A 5gwxA-2q3nB:
undetectable		 5gwxA-2q3nB:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus;
Staphylococcus
haemolyticus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 ARG B 577
ASN B 516
ASP A 336
 None
 0.92A 5gwxA-2rhqB:
undetectable		 5gwxA-2rhqB:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmh FUCOLECTIN-RELATED
PROTEIN

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		3 ARG A 493
ASN A 491
ASP A 469
 None
 0.89A 5gwxA-2wmhA:
undetectable		 5gwxA-2wmhA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apm PROTEIN-ARGININE
DEIMINASE TYPE-4

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		3 ARG A 212
ASN A 153
ASP A 157
 None
 0.91A 5gwxA-3apmA:
undetectable		 5gwxA-3apmA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euh CHROMOSOME PARTITION
PROTEIN MUKF

(Escherichia
coli) 		PF03882
(KicB)
PF17192
(MukF_M)
PF17193
(MukF_C) 		3 ARG A 102
ASN A  39
ASP A 112
 None
 0.86A 5gwxA-3euhA:
undetectable		 5gwxA-3euhA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF00202
(Aminotran_3) 		3 ARG A  46
ASN A  32
ASP A  13
 EDO  A 459 (-4.5A)
None
None
 0.86A 5gwxA-3fcrA:
undetectable		 5gwxA-3fcrA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvq FE(3+) IONS IMPORT
ATP-BINDING PROTEIN
FBPC

(Neisseria
gonorrhoeae) 		PF00005
(ABC_tran) 		3 ARG A  80
ASN A  74
ASP A  57
 None
 0.85A 5gwxA-3fvqA:
2.2		 5gwxA-3fvqA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw6 CELLULASE

(uncultured
bacterium) 		PF12891
(Glyco_hydro_44) 		3 ARG A  72
ASN A 220
ASP A  88
 None
 0.90A 5gwxA-3fw6A:
undetectable		 5gwxA-3fw6A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		3 ARG A 232
ASN A 508
ASP A 184
 None
 0.88A 5gwxA-3hjrA:
undetectable		 5gwxA-3hjrA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		3 ARG X 256
ASN X 275
ASP X 389
 None
 0.87A 5gwxA-3jb9X:
undetectable		 5gwxA-3jb9X:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jur EXO-POLY-ALPHA-D-GAL
ACTURONOSIDASE

(Thermotoga
maritima) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		3 ARG A 189
ASN A 238
ASP A 261
 None
 0.89A 5gwxA-3jurA:
undetectable		 5gwxA-3jurA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k96 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Coxiella
burnetii) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		3 ARG A 256
ASN A 257
ASP A 245
 None
 0.90A 5gwxA-3k96A:
5.6		 5gwxA-3k96A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kre PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Ehrlichia
chaffeensis) 		PF01259
(SAICAR_synt) 		3 ARG A 203
ASN A 100
ASP A 129
 CL  A 400 ( 3.7A)
CL  A 400 (-4.8A)
EDO  A 302 (-3.9A)
 0.88A 5gwxA-3kreA:
undetectable		 5gwxA-3kreA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngm EXTRACELLULAR LIPASE

(Fusarium
graminearum) 		PF01764
(Lipase_3) 		3 ARG A 202
ASN A 301
ASP A 293
 None
 0.71A 5gwxA-3ngmA:
undetectable		 5gwxA-3ngmA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 ARG A   8
ASN A 181
ASP A 227
 None
 0.87A 5gwxA-3ov3A:
undetectable		 5gwxA-3ov3A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC) 		3 ARG A1456
ASN A1441
ASP A 965
 None
 0.88A 5gwxA-3ptaA:
9.1		 5gwxA-3ptaA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6y ASPARTASE

(Bacillus sp.
YM55-1) 		PF00206
(Lyase_1) 		3 ARG A 210
ASN A 287
ASP A 294
 ARG  A 210 ( 0.6A)
ASN  A 287 ( 0.6A)
ASP  A 294 ( 0.6A)
 0.78A 5gwxA-3r6yA:
undetectable		 5gwxA-3r6yA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ARG A 661
ASN A 628
ASP A 682
 None
 0.84A 5gwxA-3tt0A:
undetectable		 5gwxA-3tt0A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 ARG A 671
ASN A 207
ASP A 150
 None
 0.78A 5gwxA-3u4aA:
undetectable		 5gwxA-3u4aA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		3 ARG A 412
ASN A 419
ASP A 135
 None
 0.69A 5gwxA-3u95A:
4.2		 5gwxA-3u95A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		3 ARG A  69
ASN A 381
ASP A  39
 None
 0.93A 5gwxA-3zbyA:
undetectable		 5gwxA-3zbyA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b09 TRANSCRIPTIONAL
REGULATORY PROTEIN
BAER

(Escherichia
coli) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		3 ARG A 199
ASN A 207
ASP A 160
 None
 0.78A 5gwxA-4b09A:
2.9		 5gwxA-4b09A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0s DEAMIDASE-DEPUPYLASE
DOP

(Acidothermus
cellulolyticus) 		PF03136
(Pup_ligase) 		3 ARG A 120
ASN A 404
ASP A 362
 None
 0.93A 5gwxA-4b0sA:
undetectable		 5gwxA-4b0sA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190
DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA12

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF01096
(TFIIS_C)
PF02150
(RNA_POL_M_15KD) 		3 ARG I 122
ASN I 124
ASP A 627
 None
 0.84A 5gwxA-4c3hI:
undetectable		 5gwxA-4c3hI:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqk POLYMERASE BASIC
PROTEIN 2

(Influenza A
virus) 		PF00604
(Flu_PB2) 		3 ARG A 415
ASN A 448
ASP A 408
 None
 0.85A 5gwxA-4eqkA:
undetectable		 5gwxA-4eqkA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjh PHOSPHOMANNOMUTASE

(Brucella
melitensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 ARG A 445
ASN A 440
ASP A 244
 G6Q  A 544 (-4.0A)
G6Q  A 544 ( 3.6A)
MG  A 552 (-2.7A)
 0.90A 5gwxA-4hjhA:
undetectable		 5gwxA-4hjhA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr6 LECTIN

(Trichosanthes
anguina) 		PF00652
(Ricin_B_lectin) 		3 ARG C 216
ASN C 121
ASP C  88
 None
 0.81A 5gwxA-4hr6C:
undetectable		 5gwxA-4hr6C:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4it1 PUTATIVE GLUCARATE
DEHYDRATASE

(Pseudomonas
fluorescens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A 404
ASN A 322
ASP A 221
 TLA  A 502 (-2.9A)
TLA  A 502 ( 4.8A)
MG  A 501 (-2.6A)
 0.74A 5gwxA-4it1A:
undetectable		 5gwxA-4it1A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE

(Pseudomonas
savastanoi) 		PF01593
(Amino_oxidase) 		3 ARG A 257
ASN A 479
ASP A 203
 None
 0.83A 5gwxA-4iv9A:
4.6		 5gwxA-4iv9A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00180
(Iso_dh) 		3 ARG A  90
ASN A  98
ASP A 250
 None
None
MG  A 401 (-2.7A)
 0.81A 5gwxA-4iwhA:
undetectable		 5gwxA-4iwhA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6c CYTOCHROME P450
MONOOXYGENASE

(Nocardia
farcinica) 		PF00067
(p450) 		3 ARG A 258
ASN A 392
ASP A  18
 None
 0.80A 5gwxA-4j6cA:
undetectable		 5gwxA-4j6cA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhc NUCLEOPORIN NUP157

(Saccharomyces
cerevisiae) 		PF08801
(Nucleoporin_N) 		3 ARG A 718
ASN A 588
ASP A 544
 None
 0.85A 5gwxA-4mhcA:
undetectable		 5gwxA-4mhcA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4na3 POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 ARG A 239
ASN A 204
ASP A  90
 None
 0.78A 5gwxA-4na3A:
undetectable		 5gwxA-4na3A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE

(Geobacillus
stearothermophilus) 		PF16499
(Melibiase_2) 		3 ARG A 216
ASN A 248
ASP A 192
 None
 0.90A 5gwxA-4nxkA:
undetectable		 5gwxA-4nxkA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1

(Homo sapiens) 		PF00899
(ThiF)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		3 ARG A 127
ASN A 166
ASP A 171
 None
 0.92A 5gwxA-4p22A:
undetectable		 5gwxA-4p22A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5y GLYCOSYL HYDROLASE,
FAMILY
31/FIBRONECTIN TYPE
III DOMAIN PROTEIN

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		3 ARG A 121
ASN A 116
ASP A 146
 None
None
NGA  A 201 ( 4.7A)
 0.85A 5gwxA-4p5yA:
undetectable		 5gwxA-4p5yA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 ARG A2774
ASN A2739
ASP A2627
 None
 0.93A 5gwxA-4qyrA:
undetectable		 5gwxA-4qyrA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rul DNA TOPOISOMERASE 1

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01396
(zf-C4_Topoisom)
PF01751
(Toprim)
PF08272
(Topo_Zn_Ribbon) 		3 ARG A 493
ASN A 548
ASP A 541
 None
 0.85A 5gwxA-4rulA:
undetectable		 5gwxA-4rulA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uul L-LACTATE
DEHYDROGENASE

(Trichomonas
vaginalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ARG A  97
ASN A 185
ASP A 158
 None
 0.66A 5gwxA-4uulA:
6.7		 5gwxA-4uulA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wum CHALCONE SYNTHASE

(Freesia hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 ARG A   8
ASN A 181
ASP A 227
 None
 0.83A 5gwxA-4wumA:
undetectable		 5gwxA-4wumA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjy CHALCONE SYNTHASE 1

(Oryza sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 ARG A  11
ASN A 184
ASP A 230
 None
 0.82A 5gwxA-4yjyA:
undetectable		 5gwxA-4yjyA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA

(Pseudomonas
fluorescens) 		PF04820
(Trp_halogenase) 		3 ARG A 195
ASN A 330
ASP A 375
 None
 0.66A 5gwxA-4z43A:
2.4		 5gwxA-4z43A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgq CELL DIVISION CYCLE
PROTEIN 123

(Schizosaccharomyces
pombe) 		PF07065
(D123) 		3 ARG A 190
ASN A 241
ASP A 135
 None
 0.91A 5gwxA-4zgqA:
undetectable		 5gwxA-4zgqA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c4r PRECORRIN-6A
REDUCTASE

(Rhodobacter
capsulatus) 		PF02571
(CbiJ) 		3 ARG A  99
ASN A 197
ASP A 108
 None
 0.87A 5gwxA-5c4rA:
4.0		 5gwxA-5c4rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxw PENICILLIN-BINDING
PROTEIN 1A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		3 ARG A 323
ASN A 319
ASP A 494
 None
 0.91A 5gwxA-5cxwA:
undetectable		 5gwxA-5cxwA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ew5 COLICIN-E9

(Escherichia
coli) 		PF03515
(Cloacin) 		3 ARG A 432
ASN A 341
ASP A 421
 None
 0.92A 5gwxA-5ew5A:
undetectable		 5gwxA-5ew5A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmq INFLUENZA A PB2
SUBUNIT

(Influenza A
virus) 		PF00604
(Flu_PB2) 		3 ARG A 415
ASN A 448
ASP A 408
 None
 0.77A 5gwxA-5fmqA:
undetectable		 5gwxA-5fmqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 ARG A 266
ASN A 201
ASP A  38
 SGN  A1522 (-2.9A)
None
CA  A1521 ( 2.8A)
 0.88A 5gwxA-5g2vA:
undetectable		 5gwxA-5g2vA:
22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE

(Methanohalophilus
portucalensis) 		PF13649
(Methyltransf_25) 		3 ARG A  43
ASN A  73
ASP A  88
 SAH  A 301 ( 3.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-2.8A)
 0.10A 5gwxA-5h02A:
41.5		 5gwxA-5h02A:
98.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc7 CEREBELLIN-1

(Homo sapiens) 		PF00386
(C1q) 		3 ARG A 150
ASN A  71
ASP A  87
 None
 0.88A 5gwxA-5kc7A:
undetectable		 5gwxA-5kc7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		3 ARG A 240
ASN A 115
ASP A 108
 None
 0.85A 5gwxA-5lrbA:
undetectable		 5gwxA-5lrbA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 3 ARG B 224
ASN B 189
ASP B  76
 None
 0.86A 5gwxA-5my0B:
undetectable		 5gwxA-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nms 25.3 KDA HEAT SHOCK
PROTEIN,
CHLOROPLASTIC
25.3 KDA HEAT SHOCK
PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF00011
(HSP20)
PF00011
(HSP20) 		3 ARG B  98
ASN B 162
ASP A 108
 None
 0.89A 5gwxA-5nmsB:
undetectable		 5gwxA-5nmsB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sx4 EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01030
(Recep_L_domain) 		3 ARG M 427
ASN M 398
ASP M 369
 None
 0.79A 5gwxA-5sx4M:
undetectable		 5gwxA-5sx4M:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szj RAS-RELATED PROTEIN
RAB-10

(Homo sapiens) 		PF00071
(Ras) 		3 ARG A 105
ASN A 106
ASP A  17
 None
 0.85A 5gwxA-5szjA:
2.8		 5gwxA-5szjA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 ARG A 708
ASN A 239
ASP A 178
 None
 0.87A 5gwxA-5tf0A:
undetectable		 5gwxA-5tf0A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc5 CHS2 CHALCONE
SYNTHASE

(Malus domestica) 		no annotation 3 ARG A   8
ASN A 181
ASP A 227
 None
 0.88A 5gwxA-5uc5A:
undetectable		 5gwxA-5uc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqz GLUCAN-BINDING
PROTEIN C, GBPC

(Streptococcus
mutans) 		no annotation 3 ARG A 180
ASN A 340
ASP A 335
 None
 0.90A 5gwxA-5uqzA:
undetectable		 5gwxA-5uqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5us8 ARGININOSUCCINATE
SYNTHASE

(Bordetella
pertussis) 		PF00764
(Arginosuc_synth) 		3 ARG A 107
ASN A 196
ASP A  49
 None
 0.92A 5gwxA-5us8A:
3.6		 5gwxA-5us8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 MAJOR CAPSID PROTEIN

(Escherichia
virus T4) 		PF07068
(Gp23) 		3 ARG A 304
ASN A 311
ASP A 432
 None
 0.88A 5gwxA-5vf3A:
undetectable		 5gwxA-5vf3A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjn CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		3 ARG A 345
ASN A  36
ASP A 405
 None
 0.90A 5gwxA-5xjnA:
undetectable		 5gwxA-5xjnA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 ARG A 706
ASN A 233
ASP A 176
 None
 0.85A 5gwxA-5xxoA:
2.4		 5gwxA-5xxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 3 ARG A1662
ASN A1694
ASP A1698
 None
 0.93A 5gwxA-6bq1A:
undetectable		 5gwxA-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea) 		no annotation 3 ARG B 593
ASN B 504
ASP B 508
 None
 0.91A 5gwxA-6bywB:
undetectable		 5gwxA-6bywB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7mdh PROTEIN (MALATE
DEHYDROGENASE)

(Sorghum bicolor) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ARG A 140
ASN A 228
ASP A 201
 None
None
ZN  A 503 ( 2.7A)
 0.60A 5gwxA-7mdhA:
4.9		 5gwxA-7mdhA:
25.70