SIMILAR PATTERNS OF AMINO ACIDS FOR 5GWK_F_EVPF102

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)


(Pyrococcus
furiosus)
PF01314
(AFOR_C)
PF02730
(AFOR_N)
4 GLY A 300
ARG A 330
MET A 274
MET A 241
None
1.33A 5gwkA-1b25A:
0.0
5gwkA-1b25A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ck7 PROTEIN (GELATINASE
A)


(Homo sapiens)
PF00040
(fn2)
PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1)
4 GLY A 255
ASP A 254
ARG A 252
MET A 282
None
1.47A 5gwkA-1ck7A:
0.0
5gwkA-1ck7A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA


(Desulfovibrio
gigas)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
4 GLY A 580
ASP A 132
ARG A 592
MET A 175
None
1.35A 5gwkA-1h0hA:
1.4
5gwkA-1h0hA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui)
PF00141
(peroxidase)
4 GLY A 482
ASP A 726
ARG A 561
MET A 621
CL  A2012 ( 4.9A)
None
None
None
1.09A 5gwkA-1itkA:
0.0
5gwkA-1itkA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Geobacillus
stearothermophilus)
PF01676
(Metalloenzyme)
PF06415
(iPGM_N)
4 GLY A 354
ASP A 356
ARG A 327
MET A 491
None
1.46A 5gwkA-1o99A:
0.2
5gwkA-1o99A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohe CDC14B2 PHOSPHATASE

(Homo sapiens)
PF00782
(DSPc)
PF14671
(DSPn)
4 GLY A 371
ASP A 372
ARG A 334
MET A 362
None
1.30A 5gwkA-1oheA:
1.6
5gwkA-1oheA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE


(Mus musculus)
PF02898
(NO_synthase)
4 GLY A 273
ASP A 274
ARG A 382
MET A 325
None
1.36A 5gwkA-1qw5A:
undetectable
5gwkA-1qw5A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 GLY A 418
ASP A 420
ARG A 103
MET A  45
None
1.41A 5gwkA-1r9jA:
1.4
5gwkA-1r9jA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT


(Corynebacterium
sp. U-96)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4)
4 GLY A 638
ASP A 715
MET A 648
MET A 666
None
1.39A 5gwkA-1vrqA:
2.1
5gwkA-1vrqA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi3 THIAMINE PHOSPHATE
PYROPHOSPHORYLASE


(Pyrococcus
furiosus)
PF02581
(TMP-TENI)
4 GLY A  81
ASP A  80
ARG A  55
MET A 186
None
1.06A 5gwkA-1xi3A:
undetectable
5gwkA-1xi3A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8a HYPOTHETICAL PROTEIN
AF1437


(Archaeoglobus
fulgidus)
no annotation 4 GLY A   8
ASP A 207
ARG A 297
MET A  21
MG  A 501 ( 4.4A)
MG  A 501 (-2.6A)
None
None
1.39A 5gwkA-1y8aA:
undetectable
5gwkA-1y8aA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)


(Arabidopsis
thaliana)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc)
4 ASP A 882
ARG A 985
MET A 704
MET A 707
None
1.44A 5gwkA-2fgeA:
undetectable
5gwkA-2fgeA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0i THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBG


(Escherichia
coli)
PF13098
(Thioredoxin_2)
4 GLY A 136
ASP A 106
MET A  84
MET A  80
None
1.43A 5gwkA-2h0iA:
undetectable
5gwkA-2h0iA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE


(Thermus
thermophilus)
PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N)
4 GLY A 408
ASP A 406
ARG A 404
MET A 267
None
1.41A 5gwkA-2ip4A:
undetectable
5gwkA-2ip4A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1


(Arabidopsis
thaliana)
PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2)
4 GLY A 336
ASP A 314
MET A  54
MET A  58
None
1.40A 5gwkA-2j3hA:
undetectable
5gwkA-2j3hA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obh CENTRIN-2

(Homo sapiens)
PF13499
(EF-hand_7)
4 GLY A  46
ASP A  41
MET A  93
MET A  97
None
1.32A 5gwkA-2obhA:
undetectable
5gwkA-2obhA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA


(Desulfovibrio
vulgaris)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
4 GLY A 330
ASP A 233
ARG A 378
MET B 284
None
None
SRM  B 503 (-2.9A)
None
1.03A 5gwkA-2v4jA:
undetectable
5gwkA-2v4jA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsb GALACTITOL
DEHYDROGENASE


(Rhodobacter
sphaeroides)
PF13561
(adh_short_C2)
4 GLY A  18
ASP A  42
ARG A  43
MET A 200
NAD  A 500 (-3.3A)
NAD  A 500 (-2.8A)
NAD  A 500 (-3.4A)
POL  A1255 ( 4.5A)
1.47A 5gwkA-2wsbA:
1.5
5gwkA-2wsbA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT


(Desulfomicrobium
norvegicum)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF12838
(Fer4_7)
4 GLY A 330
ASP A 233
ARG A 378
MET B 289
None
None
SRM  B 503 (-2.9A)
None
1.08A 5gwkA-2xsjA:
2.0
5gwkA-2xsjA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT


(Thermus
thermophilus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 GLY A 282
ASP A 279
ARG A 283
MET A 199
None
1.23A 5gwkA-2yquA:
2.5
5gwkA-2yquA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cai POSSIBLE
AMINOTRANSFERASE


(Mycobacterium
tuberculosis)
PF00266
(Aminotran_5)
4 GLY A 226
ASP A  86
ARG A  87
MET A 293
None
1.44A 5gwkA-3caiA:
undetectable
5gwkA-3caiA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Leishmania
mexicana)
PF01676
(Metalloenzyme)
PF06415
(iPGM_N)
4 GLY B 133
ASP B 167
ARG B 202
MET B 315
None
2PG  B 565 ( 2.4A)
3PG  B 564 ( 2.8A)
None
1.41A 5gwkA-3igzB:
2.1
5gwkA-3igzB:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN


(Saccharomyces
cerevisiae)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
4 GLY A  18
ASP A  17
MET A  70
MET A 119
None
1.24A 5gwkA-3k4xA:
undetectable
5gwkA-3k4xA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN


(Saccharomyces
cerevisiae)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
4 GLY A 552
ASP A 551
MET A 604
MET A 653
None
1.24A 5gwkA-3k4xA:
undetectable
5gwkA-3k4xA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6x GLUTAMINE SYNTHETASE

(Bacteroides
fragilis)
PF00120
(Gln-synt_C)
PF12437
(GSIII_N)
4 GLY A 394
ARG A 398
MET A 312
MET A 315
None
P3S  A3001 (-3.8A)
None
None
1.18A 5gwkA-3o6xA:
undetectable
5gwkA-3o6xA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaa ATP SYNTHASE SUBUNIT
BETA


(Escherichia
coli)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
4 GLY D 178
ASP D 242
ARG D 246
MET D 275
None
MG  D 601 ( 4.3A)
SO4  D 630 (-3.7A)
None
1.01A 5gwkA-3oaaD:
undetectable
5gwkA-3oaaD:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oru DUF1989 FAMILY
PROTEIN


(Ruegeria sp.
TM1040)
PF09347
(DUF1989)
4 GLY A  15
ASP A  14
ARG A 148
MET A 209
None
CL  A 301 ( 4.6A)
None
None
1.06A 5gwkA-3oruA:
undetectable
5gwkA-3oruA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE


(Azotobacter
vinelandii)
PF00148
(Oxidored_nitro)
4 GLY A 230
ASP A 231
ARG A 233
MET A  84
None
1.14A 5gwkA-3pdiA:
undetectable
5gwkA-3pdiA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvz UDP-N-ACETYLGLUCOSAM
INE 4,6-DEHYDRATASE


(Aliivibrio
fischeri)
PF02719
(Polysacc_synt_2)
4 GLY A  96
ASP A  94
ARG A 133
MET A 179
None
NAD  A 501 (-3.3A)
None
None
1.28A 5gwkA-3pvzA:
1.1
5gwkA-3pvzA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens)
PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED)
4 GLY A 743
ASP A 744
ARG A 297
MET A 731
None
1.22A 5gwkA-3snhA:
4.0
5gwkA-3snhA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxl HIAXHD3

(Humicola
insolens)
PF04616
(Glyco_hydro_43)
4 GLY A 531
ASP A  40
ARG A 533
MET A 557
None
1.39A 5gwkA-3zxlA:
undetectable
5gwkA-3zxlA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata)
PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s)
4 GLY A 962
ASP A 961
ARG A 973
MET A 850
None
1.37A 5gwkA-4bedA:
2.4
5gwkA-4bedA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dia 2-PYRONE-4,6-DICARBA
XYLATE HYDROLASE


(Sphingomonas
paucimobilis)
PF04909
(Amidohydro_2)
4 GLY A 192
ASP A 191
ARG A 199
MET A 267
None
1.48A 5gwkA-4diaA:
undetectable
5gwkA-4diaA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1


(Trypanosoma
brucei)
PF00233
(PDEase_I)
4 GLY A 763
ASP A 762
ARG A 769
MET A 814
None
1.12A 5gwkA-4i15A:
undetectable
5gwkA-4i15A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kp2 HOMOACONITASE LARGE
SUBUNIT


(Methanocaldococcus
jannaschii)
PF00330
(Aconitase)
4 GLY A 192
ASP A 158
ARG A 254
MET A 187
None
0.89A 5gwkA-4kp2A:
undetectable
5gwkA-4kp2A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN


(Saccharomyces
cerevisiae)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
4 GLY A  18
ASP A  17
MET A  70
MET A 119
None
1.37A 5gwkA-4l60A:
undetectable
5gwkA-4l60A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus)
PF04196
(Bunya_RdRp)
PF15518
(L_protein_N)
4 GLY A1475
ASP A1480
ARG A1628
MET A1688
None
1.41A 5gwkA-5amqA:
undetectable
5gwkA-5amqA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN


(Alicyclobacillus
acidocaldarius)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2)
4 GLY A  85
ASP A  84
ARG A 361
MET A 293
None
1.22A 5gwkA-5gj8A:
1.2
5gwkA-5gj8A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5l BACTERIOPHYTOCHROME
PROTEIN


(Agrobacterium
fabrum)
PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2)
4 GLY A 169
ASP A 171
ARG A 192
MET A 257
CA  A 602 ( 4.3A)
None
None
BLA  A 601 ( 3.7A)
1.35A 5gwkA-5i5lA:
undetectable
5gwkA-5i5lA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC


(Homo sapiens)
PF01411
(tRNA-synt_2c)
4 GLY A 321
ASP A 316
ARG A 325
MET A 370
None
1.06A 5gwkA-5knnA:
undetectable
5gwkA-5knnA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens)
PF03538
(VRP1)
4 GLY A1864
ASP A1865
ARG A1966
MET A1854
None
1.43A 5gwkA-5lkiA:
4.6
5gwkA-5lkiA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnb ISATIN HYDROLASE A

(Labrenzia
aggregata)
no annotation 4 GLY A 162
ASP A 161
ARG A 159
MET A 143
None
1.46A 5gwkA-5nnbA:
undetectable
5gwkA-5nnbA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti8 AMINOTRANSFERASE

(Pseudomonas sp.
M1)
PF00202
(Aminotran_3)
4 GLY A 398
ARG A 394
MET A 414
MET A  58
None
1.40A 5gwkA-5ti8A:
undetectable
5gwkA-5ti8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bog RNA
POLYMERASE-ASSOCIATE
D PROTEIN RAPA


(Escherichia
coli)
no annotation 4 GLY A 595
ASP A 598
ARG A 422
MET A 189
None
1.26A 5gwkA-6bogA:
3.7
5gwkA-6bogA:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eux POLYMERASE BASIC
PROTEIN 2


(Influenza B
virus)
no annotation 4 GLY A 370
ASP A 395
MET A 404
MET A 412
None
1.40A 5gwkA-6euxA:
undetectable
5gwkA-6euxA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC


(Spinacia
oleracea)
no annotation 4 GLY D 201
ASP D 273
ARG D 277
MET D 306
None
1.25A 5gwkA-6fkhD:
undetectable
5gwkA-6fkhD:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gc6 50S RIBOSOMAL
PROTEIN L2


(Escherichia
coli)
no annotation 4 GLY C 168
ASP C 167
ARG C 166
MET C 180
None
1.13A 5gwkA-6gc6C:
undetectable
5gwkA-6gc6C:
7.23