SIMILAR PATTERNS OF AMINO ACIDS FOR 5GWK_D_EVPD102

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfx PROTEIN (PH 2.5 ACID
PHOSPHATASE)

(Aspergillus
niger) 		PF00328
(His_Phos_2) 		4 GLY A 122
ASP A 125
ARG A  62
MET A 459
 None
 1.29A 5gwkB-1qfxA:
0.4		 5gwkB-1qfxA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq3 SUCCINATE
DEHYDROGENASE IP
SUBUNIT

(Gallus gallus) 		PF13085
(Fer2_3)
PF13534
(Fer4_17) 		4 GLY B 175
ASP B 176
ARG B 214
MET B 191
 None
 1.00A 5gwkB-1yq3B:
0.0		 5gwkB-1yq3B:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 GLY A 340
ASP A 318
ARG A 451
MET A 184
 None
None
NAD  A5555 (-4.1A)
None
 0.98A 5gwkB-2fknA:
0.6		 5gwkB-2fknA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Listeria
monocytogenes) 		PF06751
(EutB) 		4 GLY A 186
ASP A 187
ARG A 160
MET A 235
 None
 1.29A 5gwkB-2qezA:
0.0		 5gwkB-2qezA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A 202
ASP A 223
ARG A 200
MET A 239
 None
 1.24A 5gwkB-2qluA:
1.2		 5gwkB-2qluA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 GLY A 130
ASP A 180
ARG A 649
MET A  99
 None
 1.43A 5gwkB-3cemA:
1.2		 5gwkB-3cemA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9q SHEATH
TUBE

(Pseudomonas
aeruginosa) 		PF04984
(Phage_sheath_1)
PF04985
(Phage_tube)
PF17482
(Phage_sheath_1C) 		4 GLY S  16
ASP A 313
ARG S  86
MET S  56
 None
 1.21A 5gwkB-3j9qS:
undetectable		 5gwkB-3j9qS:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oy2 GLYCOSYLTRANSFERASE
B736L

(Paramecium
bursaria
Chlorella virus
NY2A) 		no annotation 4 GLY A 335
ASP A 332
ARG A 196
MET A 138
 None
 1.48A 5gwkB-3oy2A:
3.1		 5gwkB-3oy2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 GLY A 304
ASP A 317
ARG A 274
MET A 461
 None
None
SO4  A1825 (-3.1A)
None
 1.44A 5gwkB-4b9yA:
undetectable		 5gwkB-4b9yA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzx BIFUNCTIONAL ENZYME
CYSN/CYSC

(Mycobacterium
tuberculosis) 		PF01583
(APS_kinase) 		4 GLY A 563
ASP A 560
ARG A 569
MET A 494
 None
None
None
EDO  A1620 (-4.6A)
 1.33A 5gwkB-4bzxA:
2.6		 5gwkB-4bzxA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ily CHITOSANASE

(Streptomyces
sp. SirexAA-E) 		PF01374
(Glyco_hydro_46) 		4 GLY A 186
ASP A 185
ARG A 180
MET A  67
 None
 1.27A 5gwkB-4ilyA:
undetectable		 5gwkB-4ilyA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0x RIBOSOMAL
RNA-PROCESSING
PROTEIN 9

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 GLY A 362
ASP A 363
ARG A 360
MET A 407
 None
 1.07A 5gwkB-4j0xA:
undetectable		 5gwkB-4j0xA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx6 TRAP-TYPE
C4-DICARBOXYLATE:H+
SYMPORT SYSTEM
SUBSTRATE-BINDING
COMPONENT DCTP

(Shewanella
oneidensis) 		PF03480
(DctP) 		4 GLY A 327
ASP A 329
ARG A 111
MET A 124
 None
 1.38A 5gwkB-4mx6A:
0.9		 5gwkB-4mx6A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE

(Cosenzaea
myxofaciens) 		PF01266
(DAO) 		4 GLY A  33
ASP A  32
ARG A  31
MET A 334
 None
 1.24A 5gwkB-5fjnA:
0.5		 5gwkB-5fjnA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 GLY C3618
ASP C3641
ARG C3629
MET C3796
 None
 1.38A 5gwkB-5y3rC:
undetectable		 5gwkB-5y3rC:
11.61