SIMILAR PATTERNS OF AMINO ACIDS FOR 5GTR_A_ESTA601_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ayz UBIQUITIN-CONJUGATIN
G ENZYME RAD6

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		4 LEU A  55
LEU A  92
PHE A  72
LEU A 112
 None
 0.86A 5gtrA-1ayzA:
undetectable		 5gtrA-1ayzA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkd SON OF SEVENLESS-1

(Homo sapiens) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 LEU S 640
PHE S 958
LEU S 613
HIS S 700
 None
 1.04A 5gtrA-1bkdS:
1.6		 5gtrA-1bkdS:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy2 COLLAGEN ALPHA1(XV)
CHAIN

(Mus musculus) 		PF06482
(Endostatin) 		4 LEU A 241
LEU A 244
LEU A 224
HIS A 193
 None
 1.00A 5gtrA-1dy2A:
undetectable		 5gtrA-1dy2A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2

(Homo sapiens) 		PF00145
(DNA_methylase) 		4 LEU A 385
LEU A  74
PHE A 164
LEU A 377
 None
None
None
SAH  A 392 ( 4.7A)
 1.01A 5gtrA-1g55A:
0.0		 5gtrA-1g55A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7k UBIQUITIN-CONJUGATIN
G ENZYME E2 H10

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU A  81
LEU A 118
PHE A  98
LEU A 138
 None
 1.03A 5gtrA-1i7kA:
0.0		 5gtrA-1i7kA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io3 CYTOCHROME C2

(Blastochloris
viridis) 		PF00034
(Cytochrom_C) 		4 LEU A  34
PHE A  35
LEU A  93
HIS A  17
 HEM  A 108 ( 4.8A)
None
None
HEM  A 108 (-3.1A)
 1.05A 5gtrA-1io3A:
undetectable		 5gtrA-1io3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jov HI1317

(Haemophilus
influenzae) 		PF01263
(Aldose_epim) 		4 LEU A   6
LEU A   9
LEU A  37
HIS A  25
 None
 0.97A 5gtrA-1jovA:
undetectable		 5gtrA-1jovA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5a AMIDE SYNTHASE

(Vibrio cholerae) 		PF00668
(Condensation) 		4 LEU A 376
LEU A 219
PHE A 397
LEU A 241
 None
 1.04A 5gtrA-1l5aA:
0.0		 5gtrA-1l5aA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 LEU A 346
LEU A 374
PHE A 350
HIS A 342
 None
 0.96A 5gtrA-1mqqA:
0.0		 5gtrA-1mqqA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9r AGROBACTERIUM
TUMEFACIENS DPS

(Agrobacterium
tumefaciens) 		PF00210
(Ferritin) 		4 LEU A  54
LEU A  43
PHE A  58
LEU A 110
 None
 1.02A 5gtrA-1o9rA:
undetectable		 5gtrA-1o9rA:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 346
LEU A 384
PHE A 404
LEU A 428
HIS A 524
 EST  A   1 (-4.4A)
None
EST  A   1 (-4.9A)
None
EST  A   1 (-3.8A)
 0.33A 5gtrA-1pcgA:
36.2		 5gtrA-1pcgA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxy FIMBRIN-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00307
(CH) 		4 LEU A 137
LEU A 156
LEU A 166
HIS A 132
 None
 0.98A 5gtrA-1pxyA:
undetectable		 5gtrA-1pxyA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 LEU A 408
LEU A 417
LEU A 388
HIS A 395
 None
 1.03A 5gtrA-1serA:
undetectable		 5gtrA-1serA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 LEU A 656
LEU A 501
PHE A 660
LEU A 607
 None
 0.94A 5gtrA-1suvA:
undetectable		 5gtrA-1suvA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 800
LEU A 862
PHE A 681
LEU A 764
 None
 0.95A 5gtrA-1t46A:
undetectable		 5gtrA-1t46A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux4 BNI1 PROTEIN

(Saccharomyces
cerevisiae) 		PF02181
(FH2) 		4 LEU A1565
LEU A1712
PHE A1569
LEU A1591
 None
 0.69A 5gtrA-1ux4A:
undetectable		 5gtrA-1ux4A:
24.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 324
PHE A 382
LEU A 405
HIS A 494
 None
 0.79A 5gtrA-1xb7A:
28.3		 5gtrA-1xb7A:
33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6l UBIQUITIN-CONJUGATIN
G ENZYME E2E2

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU A  52
LEU A  89
PHE A  69
LEU A 109
 None
 0.99A 5gtrA-1y6lA:
undetectable		 5gtrA-1y6lA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A  22
LEU A 132
PHE A 137
LEU A 310
 None
 0.80A 5gtrA-1ykwA:
undetectable		 5gtrA-1ykwA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3d UBIQUITIN-CONJUGATIN
G ENZYME E2 1

(Caenorhabditis
elegans) 		PF00179
(UQ_con) 		4 LEU A  55
LEU A  92
PHE A  72
LEU A 112
 None
 0.93A 5gtrA-1z3dA:
undetectable		 5gtrA-1z3dA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE LARGE
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 LEU A 321
LEU A 302
LEU A 177
HIS A  51
 None
 0.85A 5gtrA-2b24A:
undetectable		 5gtrA-2b24A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bep UBIQUITIN-CONJUGATIN
G ENZYME E2-25 KDA

(Bos taurus) 		PF00179
(UQ_con) 		4 LEU A  58
LEU A  96
PHE A  75
LEU A 116
 None
 1.04A 5gtrA-2bepA:
undetectable		 5gtrA-2bepA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		4 LEU A 225
LEU A 193
PHE A 221
LEU A 181
 None
 0.74A 5gtrA-2e7uA:
undetectable		 5gtrA-2e7uA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fna CONSERVED
HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus) 		PF01637
(ATPase_2) 		4 LEU A 127
LEU A  98
PHE A 123
LEU A  80
 None
 0.95A 5gtrA-2fnaA:
undetectable		 5gtrA-2fnaA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 LEU A 556
LEU A 610
PHE A 473
LEU A 507
 None
 0.85A 5gtrA-2g3nA:
undetectable		 5gtrA-2g3nA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmi UBIQUITIN-CONJUGATIN
G ENZYME E2 13

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		4 LEU A  54
LEU A  91
PHE A  71
LEU A 111
 None
 0.91A 5gtrA-2gmiA:
undetectable		 5gtrA-2gmiA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB

(Methanocaldococcus
jannaschii) 		PF02492
(cobW) 		4 LEU A 210
LEU A 163
PHE A 206
LEU A  49
 None
 0.92A 5gtrA-2hf8A:
undetectable		 5gtrA-2hf8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		4 LEU A  47
PHE A 154
LEU A 156
HIS A  15
 None
 1.02A 5gtrA-2jkyA:
undetectable		 5gtrA-2jkyA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqa CALPAIN 8

(Homo sapiens) 		PF00648
(Peptidase_C2) 		4 LEU A 284
LEU A 232
PHE A 331
LEU A 338
 None
CSO  A 233 ( 4.3A)
None
None
 0.97A 5gtrA-2nqaA:
undetectable		 5gtrA-2nqaA:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 346
LEU A 384
PHE A 404
LEU A 428
HIS A 524
 EST  A 596 (-4.4A)
None
None
None
EST  A 596 (-4.2A)
 0.37A 5gtrA-2ocfA:
34.5		 5gtrA-2ocfA:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtz METHIONINE SYNTHASE
REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 LEU A 328
LEU A 428
PHE A 370
LEU A 441
 None
 1.05A 5gtrA-2qtzA:
undetectable		 5gtrA-2qtzA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0j UBIQUITIN CARRIER
PROTEIN

(Plasmodium
falciparum) 		PF00179
(UQ_con) 		4 LEU A  52
LEU A  89
PHE A  69
LEU A 109
 None
 0.93A 5gtrA-2r0jA:
undetectable		 5gtrA-2r0jA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb6 UBIQUITIN-CONJUGATIN
G ENZYME E2 B

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU A  55
LEU A  92
PHE A  72
LEU A 112
 None
 0.94A 5gtrA-2yb6A:
undetectable		 5gtrA-2yb6A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 LEU A 282
LEU A 331
PHE A 284
LEU A 266
 None
 1.02A 5gtrA-2z7xA:
undetectable		 5gtrA-2z7xA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 LEU A 282
LEU A 334
PHE A 284
LEU A 266
 None
 1.05A 5gtrA-2z7xA:
undetectable		 5gtrA-2z7xA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 411
LEU A 464
PHE A 416
LEU A 450
 None
 1.05A 5gtrA-3b2dA:
undetectable		 5gtrA-3b2dA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzh UBIQUITIN-CONJUGATIN
G ENZYME E2 E1

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU A  98
LEU A 135
PHE A 115
LEU A 155
 None
GOL  A 200 (-3.0A)
None
None
 1.05A 5gtrA-3bzhA:
undetectable		 5gtrA-3bzhA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 128
LEU A  80
PHE A 119
LEU A  90
 None
 0.85A 5gtrA-3ciyA:
undetectable		 5gtrA-3ciyA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqz RESPONSE REGULATOR

(Colwellia
psychrerythraea) 		PF00072
(Response_reg) 		4 LEU A  43
LEU A  99
LEU A  51
HIS A  66
 LEU  A  43 ( 0.6A)
LEU  A  99 ( 0.6A)
LEU  A  51 ( 0.5A)
HIS  A  66 ( 1.0A)
 0.91A 5gtrA-3eqzA:
undetectable		 5gtrA-3eqzA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3err FUSION PROTEIN OF
MICROTUBULE BINDING
DOMAIN FROM MOUSE
CYTOPLASMIC DYNEIN
AND SERYL-TRNA
SYNTHETASE FROM
THERMUS THERMOPHILUS

(Mus musculus;
Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF12777
(MT) 		4 LEU A 408
LEU A 417
LEU A 388
HIS A 395
 None
 0.97A 5gtrA-3errA:
undetectable		 5gtrA-3errA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gri DIHYDROOROTASE

(Staphylococcus
aureus) 		PF01979
(Amidohydro_1) 		4 LEU A 348
LEU A  10
PHE A 330
LEU A 380
 None
 0.98A 5gtrA-3griA:
undetectable		 5gtrA-3griA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 LEU B 478
LEU B 469
PHE B 474
LEU B 771
 None
 1.03A 5gtrA-3h0gB:
undetectable		 5gtrA-3h0gB:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcu UBIQUITIN-CONJUGATIN
G ENZYME E2 N

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU B  54
LEU B  91
PHE B  71
LEU B 111
 None
 0.84A 5gtrA-3hcuB:
undetectable		 5gtrA-3hcuB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA

(Methylobacillus
flagellatus) 		PF08886
(GshA) 		4 LEU A 410
LEU A  56
PHE A 221
LEU A  21
 None
 0.93A 5gtrA-3k1tA:
undetectable		 5gtrA-3k1tA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		4 LEU A 405
LEU A 418
PHE A 245
HIS A  80
 None
 0.87A 5gtrA-3k9dA:
undetectable		 5gtrA-3k9dA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmu ALPHA-PARVIN

(Homo sapiens) 		PF00307
(CH) 		4 LEU B 361
LEU B 303
PHE B 290
LEU B 276
 None
 0.92A 5gtrA-3kmuB:
undetectable		 5gtrA-3kmuB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3le1 PHOSPHOTRANSFERASE
SYSTEM, HPR-RELATED
PROTEINS

(Caldanaerobacter
subterraneus) 		PF00381
(PTS-HPr) 		4 LEU A  80
LEU A  63
PHE A  85
LEU A  14
 None
 0.94A 5gtrA-3le1A:
undetectable		 5gtrA-3le1A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		4 LEU X 643
LEU X 590
PHE X 537
LEU X 605
 None
 1.05A 5gtrA-3lxuX:
undetectable		 5gtrA-3lxuX:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oi8 UNCHARACTERIZED
PROTEIN

(Neisseria
meningitidis) 		PF00571
(CBS) 		4 LEU A 129
LEU A 113
LEU A  73
HIS A 109
 None
None
GOL  A   1 (-4.1A)
None
 1.04A 5gtrA-3oi8A:
undetectable		 5gtrA-3oi8A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfw RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large) 		4 LEU A 275
LEU A 267
PHE A 276
LEU A  84
 None
 0.96A 5gtrA-3qfwA:
undetectable		 5gtrA-3qfwA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swh PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF10540
(Membr_traf_MHD) 		4 LEU A1268
LEU A1275
PHE A1189
LEU A1181
 None
 0.89A 5gtrA-3swhA:
1.5		 5gtrA-3swhA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 LEU A  87
LEU A  39
PHE A  83
LEU A  52
 None
 0.85A 5gtrA-3wy2A:
undetectable		 5gtrA-3wy2A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 LEU A 115
LEU A  67
PHE A 111
LEU A  80
 None
 0.86A 5gtrA-3zo9A:
undetectable		 5gtrA-3zo9A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bh6 APC/C ACTIVATOR
PROTEIN CDH1

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 LEU A 281
LEU A 308
LEU A 277
HIS A 520
 None
 1.05A 5gtrA-4bh6A:
undetectable		 5gtrA-4bh6A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		4 LEU B 310
LEU B 290
PHE B 282
LEU B 263
 None
 1.03A 5gtrA-4ci2B:
undetectable		 5gtrA-4ci2B:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE

(Salmonella
enterica) 		PF01909
(NTP_transf_2)
PF13427
(DUF4111) 		4 LEU A 139
LEU A 134
LEU A  96
HIS A  32
 None
 0.97A 5gtrA-4cs6A:
undetectable		 5gtrA-4cs6A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edn BETA-PARVIN

(Homo sapiens) 		PF00307
(CH) 		4 LEU A 353
LEU A 295
PHE A 282
LEU A 268
 None
 0.99A 5gtrA-4ednA:
undetectable		 5gtrA-4ednA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fai CG5976, ISOFORM B

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		4 LEU A 229
LEU A 226
PHE A 313
HIS A 137
 PBD  A 402 (-4.8A)
None
PBD  A 402 (-3.8A)
None
 0.95A 5gtrA-4faiA:
undetectable		 5gtrA-4faiA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fyc THIOL:DISULFIDE
INTERCHANGE PROTEIN
(DSBC)

(Helicobacter
pylori) 		PF13098
(Thioredoxin_2) 		4 LEU A 184
LEU A 205
PHE A 180
LEU A 171
 None
 0.86A 5gtrA-4fycA:
undetectable		 5gtrA-4fycA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpr UBIQUITIN-CONJUGATIN
G ENZYME FAMILY
PROTEIN

(Entamoeba
histolytica) 		PF00179
(UQ_con) 		4 LEU A  52
LEU A  89
PHE A  69
LEU A 109
 None
 1.04A 5gtrA-4gprA:
undetectable		 5gtrA-4gprA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 LEU A 341
LEU A 323
PHE A 551
LEU A 395
 None
 0.79A 5gtrA-4hozA:
undetectable		 5gtrA-4hozA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5n SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA -
CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG CHIMERIC
CONSTRUCT

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 LEU B 238
LEU B 248
PHE B 237
LEU B 298
 None
 1.01A 5gtrA-4i5nB:
undetectable		 5gtrA-4i5nB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9f GLYCEROL 3-PHOSPHATE
PHOSPHATASE

(Mycobacterium
tuberculosis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 LEU A 254
LEU A 264
LEU A 205
HIS A 258
 None
 0.99A 5gtrA-4i9fA:
undetectable		 5gtrA-4i9fA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		4 LEU A1000
LEU A1030
PHE A 996
LEU A1054
 None
 1.05A 5gtrA-4kf7A:
undetectable		 5gtrA-4kf7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 LEU A 238
LEU A 248
PHE A 237
LEU A 298
 None
 0.91A 5gtrA-4mewA:
undetectable		 5gtrA-4mewA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhp GLUTAMINYL CYCLASE,
PUTATIVE

(Ixodes
scapularis) 		PF04389
(Peptidase_M28) 		4 LEU A 239
LEU A 236
PHE A 317
HIS A 128
 None
 0.97A 5gtrA-4mhpA:
undetectable		 5gtrA-4mhpA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mte ZINC UPTAKE
REGULATION PROTEIN

(Escherichia
coli) 		PF01475
(FUR) 		4 LEU A   9
LEU A  29
PHE A  91
LEU A  70
 None
 1.01A 5gtrA-4mteA:
undetectable		 5gtrA-4mteA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		4 LEU A 494
LEU A 509
PHE A 744
HIS A 526
 None
 0.86A 5gtrA-4nh0A:
undetectable		 5gtrA-4nh0A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN

(Haemophilus
influenzae) 		PF03480
(DctP) 		4 LEU A 109
LEU A  92
PHE A 110
LEU A 120
 None
2UF  A 401 (-4.3A)
None
None
 0.97A 5gtrA-4pbqA:
undetectable		 5gtrA-4pbqA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn5 FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
3

(Escherichia
coli) 		PF02302
(PTS_IIB) 		4 LEU A  62
LEU A   4
PHE A  74
LEU A  49
 None
 1.05A 5gtrA-4tn5A:
undetectable		 5gtrA-4tn5A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uob ENDONUCLEASE III-3

(Deinococcus
radiodurans) 		PF00730
(HhH-GPD) 		4 LEU A 104
LEU A 313
PHE A 100
LEU A 261
 None
SF4  A1329 ( 4.8A)
None
None
 0.93A 5gtrA-4uobA:
undetectable		 5gtrA-4uobA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wva UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		PF01204
(Trehalase) 		4 LEU A 135
LEU A 142
PHE A  59
LEU A  33
 None
 0.93A 5gtrA-4wvaA:
undetectable		 5gtrA-4wvaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xd9 RIBOSOME BIOGENESIS
PROTEIN, PUTATIVE
(AFU_ORTHOLOGUE
AFUA_8G04790)

(Aspergillus
nidulans) 		PF04427
(Brix) 		4 LEU A 171
LEU A 164
PHE A 172
LEU A 206
 None
 0.83A 5gtrA-4xd9A:
undetectable		 5gtrA-4xd9A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14629
(ORC4_C) 		4 LEU D 100
LEU D  88
PHE D 121
LEU D 164
 None
 0.80A 5gtrA-4xgcD:
undetectable		 5gtrA-4xgcD:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yii UBIQUITIN-CONJUGATIN
G ENZYME E2 C

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU U  81
LEU U 118
PHE U  98
LEU U 138
 None
 1.01A 5gtrA-4yiiU:
undetectable		 5gtrA-4yiiU:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Homo sapiens) 		PF04389
(Peptidase_M28) 		4 LEU A 249
LEU A 246
PHE A 325
HIS A 140
 None
 1.01A 5gtrA-4yu9A:
undetectable		 5gtrA-4yu9A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 LEU R 205
LEU R 232
LEU R 201
HIS R 444
 None
 0.98A 5gtrA-5a31R:
undetectable		 5gtrA-5a31R:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4p REPEBODY

(synthetic
construct) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 LEU A 161
LEU A 113
PHE A 152
LEU A 123
 None
 1.03A 5gtrA-5b4pA:
undetectable		 5gtrA-5b4pA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmt UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		no annotation 4 LEU A 133
LEU A 181
PHE A 254
LEU A 214
 None
 0.79A 5gtrA-5bmtA:
undetectable		 5gtrA-5bmtA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brq GLYCOSIDE HYDROLASE
FAMILY 13

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 LEU A  88
LEU A  40
PHE A  84
LEU A  53
 None
 0.99A 5gtrA-5brqA:
undetectable		 5gtrA-5brqA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by8 RPF2

(Aspergillus
nidulans) 		PF04427
(Brix) 		4 LEU A 171
LEU A 164
PHE A 172
LEU A 206
 None
 0.84A 5gtrA-5by8A:
undetectable		 5gtrA-5by8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfl UBIQUITIN-CONJUGATIN
G ENZYME E2 K

(Homo sapiens) 		PF00179
(UQ_con)
PF00627
(UBA) 		4 LEU A  58
LEU A  96
PHE A  75
LEU A 116
 None
GOL  A 301 (-3.5A)
None
None
 1.03A 5gtrA-5dflA:
undetectable		 5gtrA-5dflA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta) 		PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 LEU A 665
LEU A 711
PHE A 670
LEU A 704
 None
 1.03A 5gtrA-5gmhA:
undetectable		 5gtrA-5gmhA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvi UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Danio rerio) 		PF00443
(UCH) 		4 LEU A  82
LEU A 139
PHE A  88
LEU A 169
 None
 0.90A 5gtrA-5gviA:
undetectable		 5gtrA-5gviA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzo UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN

(Chaetomium
thermophilum) 		PF06427
(UDP-g_GGTase) 		4 LEU A 811
LEU A 717
PHE A 828
LEU A 703
 None
 1.05A 5gtrA-5mzoA:
undetectable		 5gtrA-5mzoA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngz UBIQUITIN-CONJUGATIN
G ENZYME E2 T

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU A  53
LEU A  90
PHE A  70
LEU A 114
 None
 1.05A 5gtrA-5ngzA:
undetectable		 5gtrA-5ngzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkz UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA

(Ogataea angusta) 		no annotation 4 LEU A  63
LEU A 123
PHE A  80
LEU A 143
 None
 1.03A 5gtrA-5nkzA:
undetectable		 5gtrA-5nkzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Homo sapiens) 		PF00443
(UCH) 		4 LEU A  86
LEU A 143
PHE A  92
LEU A 173
 None
 1.04A 5gtrA-5ohkA:
undetectable		 5gtrA-5ohkA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojj UBIQUITIN-CONJUGATIN
G ENZYME E2 T

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU A  53
LEU A  90
PHE A  70
LEU A 114
 None
 1.03A 5gtrA-5ojjA:
undetectable		 5gtrA-5ojjA:
18.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 298
PHE A 356
LEU A 380
HIS A 475
 EST  A 601 (-4.1A)
EST  A 601 ( 4.9A)
None
EST  A 601 (-4.4A)
 0.30A 5gtrA-5toaA:
29.9		 5gtrA-5toaA:
59.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 4 LEU A 152
LEU A 184
PHE A 148
LEU A 231
 None
 1.03A 5gtrA-5turA:
undetectable		 5gtrA-5turA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis) 		no annotation 4 LEU A 133
LEU A 157
PHE A  84
LEU A  64
 None
 0.99A 5gtrA-5ufmA:
undetectable		 5gtrA-5ufmA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Homo sapiens) 		PF13191
(AAA_16)
PF14629
(ORC4_C) 		4 LEU C 111
LEU C  99
PHE C 132
LEU C 176
 None
 1.02A 5gtrA-5uj7C:
undetectable		 5gtrA-5uj7C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w99 PBTD

(Planobispora
rosea) 		no annotation 4 LEU A  45
LEU A 107
LEU A  25
HIS A  66
 None
 1.01A 5gtrA-5w99A:
undetectable		 5gtrA-5w99A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides) 		no annotation 4 LEU A 264
LEU A 298
PHE A 344
LEU A 330
 None
 0.95A 5gtrA-5wypA:
undetectable		 5gtrA-5wypA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7u TREHALOSE SYNTHASE

(Thermobaculum
terrenum) 		no annotation 4 LEU A  87
LEU A  39
PHE A  83
LEU A  52
 None
 0.92A 5gtrA-5x7uA:
undetectable		 5gtrA-5x7uA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans) 		no annotation 4 LEU A  88
LEU A  40
PHE A  84
LEU A  53
 None
 1.04A 5gtrA-5ykbA:
undetectable		 5gtrA-5ykbA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2

(Homo sapiens) 		no annotation 4 LEU A 275
PHE A 176
LEU A 137
HIS A 315
 None
 0.97A 5gtrA-6apjA:
undetectable		 5gtrA-6apjA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emo -

(-) 		no annotation 4 LEU A 377
PHE A 476
LEU A 363
HIS A 356
 None
 0.98A 5gtrA-6emoA:
undetectable		 5gtrA-6emoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emr -

(-) 		no annotation 4 LEU A 377
PHE A 488
LEU A 363
HIS A 356
 None
 0.91A 5gtrA-6emrA:
undetectable		 5gtrA-6emrA:
undetectable