SIMILAR PATTERNS OF AMINO ACIDS FOR 5GTR_A_ESTA601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (BETA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		5 ALA B 173
LEU B 153
LEU B 152
ILE B 493
GLY B 491
 None
 0.99A 5gtrA-1a6dB:
undetectable		 5gtrA-1a6dB:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE

(Streptomyces
antibioticus) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03726
(PNPase) 		5 LEU A 510
GLU A 513
ARG A 339
ILE A 561
GLY A 487
 None
 1.12A 5gtrA-1e3hA:
undetectable		 5gtrA-1e3hA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekq HYDROXYETHYLTHIAZOLE
KINASE

(Bacillus
subtilis) 		PF02110
(HK) 		5 LEU A 199
ALA A 196
LEU A 248
LEU A 249
GLY A 242
 None
 1.00A 5gtrA-1ekqA:
0.0		 5gtrA-1ekqA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		5 ALA A 212
GLU A 191
LEU A 298
ARG A 186
LEU A 223
 None
 1.07A 5gtrA-1g0vA:
undetectable		 5gtrA-1g0vA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		5 LEU A 116
LEU A 115
ILE A  83
GLY A 121
LEU A 123
 None
 0.95A 5gtrA-1gynA:
undetectable		 5gtrA-1gynA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i0a DELTA CRYSTALLIN I

(Meleagris
gallopavo) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		6 LEU A  49
ALA A  46
LEU A  60
ILE A 100
GLY A  66
LEU A  67
 None
 1.19A 5gtrA-1i0aA:
0.1		 5gtrA-1i0aA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldn L-LACTATE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 263
LEU A 134
LEU A 132
ILE A 298
LEU A 270
 None
 1.09A 5gtrA-1ldnA:
undetectable		 5gtrA-1ldnA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkl NK-LYSIN

(Sus scrofa) 		PF05184
(SapB_1) 		5 MET A  49
GLU A  24
LEU A  61
ILE A  69
LEU A  14
 None
 1.05A 5gtrA-1nklA:
0.7		 5gtrA-1nklA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE

(Sus scrofa) 		PF01144
(CoA_trans) 		5 LEU A  46
ALA A  48
LEU A 170
ILE A  30
GLY A  24
 None
 1.13A 5gtrA-1opeA:
undetectable		 5gtrA-1opeA:
18.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 MET A 343
LEU A 349
ALA A 350
GLU A 353
LEU A 387
MET A 388
LEU A 391
ARG A 394
MET A 421
ILE A 424
GLY A 521
LEU A 525
 EST  A   1 ( 4.0A)
EST  A   1 ( 4.8A)
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
None
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
EST  A   1 ( 4.5A)
EST  A   1 ( 4.1A)
EST  A   1 (-3.6A)
 0.49A 5gtrA-1pcgA:
36.2		 5gtrA-1pcgA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvt SUGAR-PHOSPHATE
ALDOLASE

(Thermotoga
maritima) 		PF00596
(Aldolase_II) 		5 ALA A 215
GLU A 216
LEU A 127
GLY A 193
LEU A 188
 None
 1.03A 5gtrA-1pvtA:
undetectable		 5gtrA-1pvtA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3s THERMOSOME ALPHA
SUBUNIT

(Thermococcus
sp. JCM 11816) 		PF00118
(Cpn60_TCP1) 		5 ALA A 175
LEU A 155
LEU A 154
ILE A 495
GLY A 493
 None
 1.01A 5gtrA-1q3sA:
2.5		 5gtrA-1q3sA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgv TRNA PSEUDOURIDINE
SYNTHASE B

(Mycobacterium
tuberculosis) 		PF01509
(TruB_N)
PF09142
(TruB_C)
PF16198
(TruB_C_2) 		5 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.04A 5gtrA-1sgvA:
undetectable		 5gtrA-1sgvA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgv TRNA PSEUDOURIDINE
SYNTHASE B

(Mycobacterium
tuberculosis) 		PF01509
(TruB_N)
PF09142
(TruB_C)
PF16198
(TruB_C_2) 		5 ALA A 231
LEU A 226
LEU A 224
ILE A  51
LEU A  63
 None
 1.14A 5gtrA-1sgvA:
undetectable		 5gtrA-1sgvA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybf AMP NUCLEOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01048
(PNP_UDP_1) 		5 LEU A 207
LEU A 206
ILE A  92
GLY A 239
LEU A 236
 None
 1.08A 5gtrA-1ybfA:
undetectable		 5gtrA-1ybfA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7s HUMAN COXSACKIEVIRUS
A21

(Enterovirus C) 		PF00073
(Rhv) 		5 LEU 2 186
ALA 2 187
LEU 2 181
LEU 2 177
GLY 2  77
 None
 1.11A 5gtrA-1z7s2:
undetectable		 5gtrA-1z7s2:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aao CALCIUM-DEPENDENT
PROTEIN KINASE,
ISOFORM AK1

(Arabidopsis
thaliana) 		PF13499
(EF-hand_7) 		5 LEU A  60
LEU A  68
MET A  32
ILE A  36
GLY A  52
 None
 1.07A 5gtrA-2aaoA:
undetectable		 5gtrA-2aaoA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Prosthecochloris
vibrioformis) 		PF00490
(ALAD) 		5 ALA A  66
GLU A  69
LEU A  40
ILE A  86
GLY A  85
 None
 1.04A 5gtrA-2c1hA:
undetectable		 5gtrA-2c1hA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 550
ALA A 546
MET A 680
GLY A 675
LEU A 673
 None
 1.14A 5gtrA-2f57A:
undetectable		 5gtrA-2f57A:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 271
ALA A 272
GLU A 275
LEU A 309
ARG A 316
 OHT  A 500 ( 4.4A)
OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
 0.46A 5gtrA-2gpvA:
25.9		 5gtrA-2gpvA:
37.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5g ALR4455 PROTEIN

(Nostoc sp. PCC
7120) 		PF00378
(ECH_1) 		5 LEU D 103
LEU D 104
ARG D 221
ILE D 236
GLY D  96
 None
 0.90A 5gtrA-2j5gD:
undetectable		 5gtrA-2j5gD:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 MET A 343
LEU A 349
ALA A 350
GLU A 353
LEU A 387
MET A 388
LEU A 391
ARG A 394
MET A 421
ILE A 424
GLY A 521
LEU A 525
 EST  A 596 (-4.8A)
EST  A 596 ( 4.1A)
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
EST  A 596 ( 4.2A)
None
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
EST  A 596 ( 4.7A)
EST  A 596 ( 4.0A)
EST  A 596 (-3.6A)
 0.63A 5gtrA-2ocfA:
34.5		 5gtrA-2ocfA:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF02542
(YgbB) 		5 LEU A  86
ALA A  83
GLU A  82
GLY A 124
LEU A 123
 None
 0.99A 5gtrA-2pmpA:
undetectable		 5gtrA-2pmpA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  35
ALA A  36
LEU A  77
ARG A  80
MET A 108
 1CA  A 247 ( 4.4A)
1CA  A 247 (-3.6A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
 0.75A 5gtrA-2q3yA:
27.1		 5gtrA-2q3yA:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Paraburkholderia
phytofirmans) 		PF13407
(Peripla_BP_4) 		5 ALA A  44
LEU A  92
LEU A  93
ILE A  86
GLY A  85
 None
 1.05A 5gtrA-2rjoA:
undetectable		 5gtrA-2rjoA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Homo sapiens) 		PF00133
(tRNA-synt_1) 		5 LEU A 449
ALA A 463
GLU A 462
ILE A 434
GLY A 471
 None
 1.14A 5gtrA-2wfdA:
undetectable		 5gtrA-2wfdA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 512
LEU A 604
LEU A 603
GLY A 610
LEU A 686
 None
 1.06A 5gtrA-2wntA:
undetectable		 5gtrA-2wntA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7x SENSOR PROTEIN

(Bacteroides
thetaiotaomicron) 		PF13407
(Peripla_BP_4) 		5 ALA A 201
GLU A 204
LEU A 160
ILE A 247
GLY A 246
 None
 0.97A 5gtrA-2x7xA:
undetectable		 5gtrA-2x7xA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 MET A 503
ALA A 524
LEU A 493
MET A 492
GLY A 575
 PGR  A1764 ( 3.5A)
None
None
None
PGR  A1742 (-4.2A)
 0.88A 5gtrA-2xe4A:
undetectable		 5gtrA-2xe4A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		5 GLU A 373
ARG A  64
ILE A 179
GLY A  44
LEU A  41
 None
 1.03A 5gtrA-2zkjA:
undetectable		 5gtrA-2zkjA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 LEU A 326
LEU A 311
ILE A 435
GLY A 316
LEU A 318
 None
 1.10A 5gtrA-3d1jA:
undetectable		 5gtrA-3d1jA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA X 319
GLU X 318
LEU X 314
ARG X  11
GLY X 220
 None
 1.11A 5gtrA-3e3bX:
undetectable		 5gtrA-3e3bX:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF00480
(ROK) 		5 LEU A 625
ALA A 624
LEU A 671
ILE A 678
GLY A 646
 None
 1.04A 5gtrA-3eo3A:
undetectable		 5gtrA-3eo3A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ALA A 483
LEU A 341
LEU A 342
MET A 288
ILE A 291
 None
 1.07A 5gtrA-3g4gA:
3.1		 5gtrA-3g4gA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Escherichia
coli) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 LEU A 482
GLU A 485
ARG A 315
ILE A 533
GLY A 463
 None
 1.11A 5gtrA-3gmeA:
undetectable		 5gtrA-3gmeA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goa 3-KETOACYL-COA
THIOLASE

(Salmonella
enterica) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ALA A 246
LEU A  34
MET A  35
LEU A  38
ILE A  53
 None
 1.12A 5gtrA-3goaA:
undetectable		 5gtrA-3goaA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hig AMILORIDE-SENSITIVE
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 LEU A  75
ALA A  97
GLU A  96
MET A 125
ILE A 101
 None
 0.85A 5gtrA-3higA:
undetectable		 5gtrA-3higA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE

(Methanocaldococcus
jannaschii) 		PF02277
(DBI_PRT) 		6 LEU A 246
ALA A 247
LEU A 163
MET A 216
GLY A 213
LEU A 209
 None
 1.44A 5gtrA-3l0zA:
undetectable		 5gtrA-3l0zA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		5 ALA A 351
LEU A 202
LEU A 205
ILE A 297
GLY A 294
 NA  A 751 (-4.9A)
None
None
None
None
 1.08A 5gtrA-3mpnA:
undetectable		 5gtrA-3mpnA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ALA A 391
LEU A 249
LEU A 250
MET A 196
ILE A 199
 None
 1.08A 5gtrA-3o57A:
2.8		 5gtrA-3o57A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA

(Sulfolobus
solfataricus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		5 MET A 215
LEU A 246
ALA A 289
GLU A 288
GLY A 298
 None
None
None
None
5GP  A   1 (-3.7A)
 1.12A 5gtrA-3penA:
undetectable		 5gtrA-3penA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtp ENOLASE 1

(Entamoeba
histolytica) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ALA A 218
LEU A 161
ILE A 263
GLY A 260
LEU A 259
 None
 0.95A 5gtrA-3qtpA:
undetectable		 5gtrA-3qtpA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2h BACTERIOFERRITIN

(Pseudomonas
aeruginosa) 		PF00210
(Ferritin) 		5 LEU A  19
LEU A  59
LEU A  58
ILE A   8
GLY A  67
 None
 1.14A 5gtrA-3r2hA:
undetectable		 5gtrA-3r2hA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ALA A 317
LEU A 175
LEU A 176
MET A 122
ILE A 125
 ALA  A 317 ( 0.0A)
LEU  A 175 ( 0.6A)
LEU  A 176 ( 0.6A)
MET  A 122 ( 0.0A)
ILE  A 125 ( 0.6A)
 1.08A 5gtrA-3sl5A:
3.2		 5gtrA-3sl5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swh PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF10540
(Membr_traf_MHD) 		5 LEU A1477
ALA A1357
MET A1399
ILE A1403
GLY A1333
 None
 1.11A 5gtrA-3swhA:
undetectable		 5gtrA-3swhA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzt GLYCOSYL TRANSFERASE
FAMILY 8

(Anaerococcus
prevotii) 		PF01501
(Glyco_transf_8) 		5 LEU A   5
ALA A   4
LEU A 118
ILE A 122
LEU A 163
 None
EDO  A 302 (-4.5A)
EDO  A 302 (-4.3A)
None
None
 1.10A 5gtrA-3tztA:
undetectable		 5gtrA-3tztA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 LEU A 534
GLU A 537
ARG A 358
ILE A 585
GLY A 508
 None
 1.05A 5gtrA-3u1kA:
undetectable		 5gtrA-3u1kA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wau 4-O-BETA-D-MANNOSYL-
D-GLUCOSE
PHOSPHORYLASE

(Bacteroides
fragilis) 		PF04041
(Glyco_hydro_130) 		5 GLU A 314
LEU A 323
ARG A  35
ILE A 250
GLY A 274
 None
 1.10A 5gtrA-3wauA:
undetectable		 5gtrA-3wauA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbh ALKALINE PHOSPHATASE

(Halomonas sp.
#593) 		PF00245
(Alk_phosphatase) 		5 ALA A 290
GLU A 289
MET A  14
ILE A 268
GLY A 266
 None
None
None
None
MG  A 501 ( 4.4A)
 0.95A 5gtrA-3wbhA:
undetectable		 5gtrA-3wbhA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl0 CELL CYCLE ARREST
PROTEIN BUB3
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF08171
(Mad3_BUB1_II) 		5 LEU B 340
ALA B 341
ILE A 104
GLY A  79
LEU A 102
 None
 1.01A 5gtrA-4bl0B:
undetectable		 5gtrA-4bl0B:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 LEU A 383
LEU A 272
ILE A 410
GLY A 266
LEU A 265
 None
 1.15A 5gtrA-4c9mA:
2.6		 5gtrA-4c9mA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		5 LEU A 357
ALA A 356
LEU A  35
GLY A 399
LEU A 397
 None
 0.96A 5gtrA-4ccdA:
undetectable		 5gtrA-4ccdA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 460
LEU A 488
MET A 449
ILE A 450
GLY A 499
 None
 0.96A 5gtrA-4cokA:
undetectable		 5gtrA-4cokA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		6 MET A 114
LEU A 102
ALA A 106
LEU A  82
LEU A  81
ILE A  27
 None
 1.24A 5gtrA-4dqdA:
undetectable		 5gtrA-4dqdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A1016
LEU A1017
MET A1052
GLY A1010
LEU A1009
 None
 0.95A 5gtrA-4g34A:
undetectable		 5gtrA-4g34A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 ALA A  56
LEU A 324
LEU A 327
ILE A 189
GLY A 214
 None
 1.01A 5gtrA-4gp1A:
2.4		 5gtrA-4gp1A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Dickeya
paradisiaca) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 311
ALA A 308
LEU A 341
ILE A 330
GLY A 334
 None
 1.02A 5gtrA-4ihcA:
undetectable		 5gtrA-4ihcA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j34 KYNURENINE
3-MONOOXYGENASE

(Saccharomyces
cerevisiae) 		PF01494
(FAD_binding_3) 		5 LEU A  19
ALA A  20
LEU A  62
GLY A 330
LEU A 312
 None
 1.13A 5gtrA-4j34A:
undetectable		 5gtrA-4j34A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6c CYTOCHROME P450
MONOOXYGENASE

(Nocardia
farcinica) 		PF00067
(p450) 		5 LEU A 362
ALA A 363
GLU A 366
GLY A 289
LEU A 285
 HEM  A 502 ( 4.6A)
HEM  A 502 (-2.9A)
None
None
None
 1.07A 5gtrA-4j6cA:
undetectable		 5gtrA-4j6cA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjn HISTONE H2A.2
HISTONE H2B.2

(Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		5 LEU D  83
ALA D  80
GLU D  79
GLY C  38
LEU C  35
 None
 1.07A 5gtrA-4jjnD:
undetectable		 5gtrA-4jjnD:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA

(Bacillus
subtilis) 		PF01041
(DegT_DnrJ_EryC1) 		5 LEU A 159
ALA A 160
ILE A 220
GLY A 132
LEU A 134
 None
 1.11A 5gtrA-4k2bA:
undetectable		 5gtrA-4k2bA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpr THIOREDOXIN
REDUCTASE 1,
CYTOPLASMIC

(Rattus
norvegicus) 		no annotation 5 ALA E 290
LEU E 288
LEU E 194
ILE E 245
GLY E 207
 None
 0.99A 5gtrA-4kprE:
undetectable		 5gtrA-4kprE:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		6 ALA A 263
GLU A 262
LEU A 210
ARG A 255
ILE A 183
GLY A 184
 None
 1.47A 5gtrA-4llsA:
undetectable		 5gtrA-4llsA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA E 318
GLU E 317
LEU E 313
ARG E  10
GLY E 219
 None
 1.10A 5gtrA-4md8E:
undetectable		 5gtrA-4md8E:
19.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 LEU A 286
ALA A 287
GLU A 290
LEU A 324
ARG A 331
GLY A 444
 None
 1.07A 5gtrA-4n1yA:
30.4		 5gtrA-4n1yA:
39.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		7 LEU A 286
ALA A 287
GLU A 290
LEU A 324
ARG A 331
ILE A 361
GLY A 447
 None
 0.60A 5gtrA-4n1yA:
30.4		 5gtrA-4n1yA:
39.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		7 LEU A 286
ALA A 287
GLU A 290
LEU A 324
ARG A 331
MET A 358
ILE A 361
 None
 0.71A 5gtrA-4n1yA:
30.4		 5gtrA-4n1yA:
39.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3h KSHV PROTEASE

(Human
gammaherpesvirus
8) 		PF00716
(Peptidase_S21) 		5 ALA A 154
GLU A 155
LEU A 173
GLY A  57
LEU A  56
 None
 1.12A 5gtrA-4p3hA:
undetectable		 5gtrA-4p3hA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecium) 		PF13377
(Peripla_BP_3) 		5 LEU A 308
LEU A 309
ILE A  88
GLY A 302
LEU A 301
 None
 1.14A 5gtrA-4rk1A:
undetectable		 5gtrA-4rk1A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 772
ALA A 773
LEU A 810
LEU A 814
ARG A 817
 CV7  A1987 ( 4.5A)
CV7  A1987 (-3.5A)
CV7  A1987 (-4.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
 0.39A 5gtrA-4udbA:
26.7		 5gtrA-4udbA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umz CYTOCHROME P450
HYDROXYLASE PIKC

(Streptomyces
venezuelae) 		PF00067
(p450) 		5 LEU A 359
ALA A 360
GLU A 363
GLY A 288
LEU A 284
 HEM  A1407 ( 4.6A)
HEM  A1407 (-3.3A)
None
None
None
 1.08A 5gtrA-4umzA:
2.4		 5gtrA-4umzA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwa RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF00622
(SPRY)
PF01365
(RYDR_ITPR)
PF02026
(RyR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		5 MET A 403
LEU A 410
LEU A 445
LEU A 443
GLY A 450
 None
 0.98A 5gtrA-4uwaA:
undetectable		 5gtrA-4uwaA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ALA A 563
LEU A 421
LEU A 422
MET A 368
ILE A 371
 None
 1.07A 5gtrA-4wziA:
3.3		 5gtrA-4wziA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomyces
pombe) 		PF01008
(IF-2B) 		5 ALA C 299
LEU G 363
LEU G 364
ILE G 326
GLY G 357
 None
 0.90A 5gtrA-5b04C:
undetectable		 5gtrA-5b04C:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bvr ALPHA-ACTININ-LIKE
PROTEIN 1

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		5 MET A  84
LEU A  76
LEU A  43
ILE A  50
GLY A  51
 None
 1.10A 5gtrA-5bvrA:
undetectable		 5gtrA-5bvrA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8a LIGHT-DEPENDENT
TRANSCRIPTIONAL
REGULATOR CARH

(Thermus
thermophilus) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		5 LEU A 152
LEU A 124
LEU A 121
GLY A  84
LEU A  87
 None
B12  A 300 (-4.1A)
B12  A 300 (-4.3A)
None
None
 1.07A 5gtrA-5c8aA:
undetectable		 5gtrA-5c8aA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwe CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 LEU A 349
ALA A 350
GLU A 353
GLY A 278
LEU A 274
 HEM  A 403 ( 4.9A)
HEM  A 403 (-3.3A)
None
None
None
 1.13A 5gtrA-5cweA:
2.1		 5gtrA-5cweA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4y HOMOSERINE
O-ACETYLTRANSFERASE

(Pseudomonas
veronii) 		PF00561
(Abhydrolase_1) 		5 ALA A 163
LEU A 336
MET A  63
ILE A  66
GLY A 327
 None
 1.15A 5gtrA-5e4yA:
undetectable		 5gtrA-5e4yA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		5 LEU A  24
LEU A  60
LEU A 101
GLY A  93
LEU A  89
 None
 1.15A 5gtrA-5e7pA:
undetectable		 5gtrA-5e7pA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gam PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08082
(PRO8NT)
PF08083
(PROCN) 		5 MET A 622
LEU A 175
LEU A 176
ILE A 719
LEU A 168
 None
None
None
C  U 111 ( 4.4A)
None
 1.11A 5gtrA-5gamA:
undetectable		 5gtrA-5gamA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hwq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Myxococcus
xanthus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 LEU A 337
ALA A 248
LEU A 322
GLY A 302
LEU A 301
 None
None
None
GOL  A 502 ( 3.8A)
GOL  A 502 (-4.0A)
 1.01A 5gtrA-5hwqA:
undetectable		 5gtrA-5hwqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijb TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF00560
(LRR_1)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU A 207
LEU A 194
LEU A 197
GLY A 251
LEU A 249
 None
 0.94A 5gtrA-5ijbA:
undetectable		 5gtrA-5ijbA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbe INACTIVE
GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF02324
(Glyco_hydro_70) 		5 ALA A1016
GLU A1053
MET A1441
ILE A1486
GLY A 973
 None
None
None
GLC  A1708 ( 4.2A)
GLC  A1708 ( 3.5A)
 1.14A 5gtrA-5jbeA:
undetectable		 5gtrA-5jbeA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ALA A  96
LEU A  53
ILE A 395
GLY A 267
LEU A 146
 None
 1.11A 5gtrA-5lnqA:
undetectable		 5gtrA-5lnqA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 315
ALA A 316
LEU A 109
ILE A 266
GLY A 265
 None
 1.11A 5gtrA-5macA:
undetectable		 5gtrA-5macA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mji BRAMP DOMAIN PROTEIN

(Streptomyces
davaonensis) 		PF03358
(FMN_red) 		5 LEU A   8
LEU A 104
LEU A 107
GLY A 150
LEU A 146
 None
 1.07A 5gtrA-5mjiA:
undetectable		 5gtrA-5mjiA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 772
ALA A 773
LEU A 814
ARG A 817
MET A 845
 ECV  A1101 ( 3.9A)
ECV  A1101 (-3.8A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
 0.74A 5gtrA-5mwpA:
26.2		 5gtrA-5mwpA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 5 ALA A  22
LEU A  19
ILE A 267
GLY A 223
LEU A 219
 None
 0.92A 5gtrA-5od2A:
undetectable		 5gtrA-5od2A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 5 ALA A 563
LEU A 421
LEU A 422
MET A 368
ILE A 371
 None
 1.07A 5gtrA-5ohjA:
3.2		 5gtrA-5ohjA:
17.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 301
ALA A 302
GLU A 305
ARG A 346
ILE A 373
LEU A 476
 EST  A 601 ( 4.3A)
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
EST  A 601 (-4.1A)
None
EST  A 601 (-3.5A)
 1.23A 5gtrA-5toaA:
29.9		 5gtrA-5toaA:
59.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 MET A 295
LEU A 301
ALA A 302
GLU A 305
LEU A 339
MET A 340
LEU A 343
ARG A 346
ILE A 376
GLY A 472
LEU A 476
 EST  A 601 ( 4.4A)
EST  A 601 ( 4.3A)
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.8A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.0A)
EST  A 601 (-3.5A)
 0.61A 5gtrA-5toaA:
29.9		 5gtrA-5toaA:
59.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 LEU A  96
GLU A 168
LEU A 195
ILE A  39
LEU A  34
 None
 1.13A 5gtrA-5u4hA:
undetectable		 5gtrA-5u4hA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4n FRUCTOSE-1

(Neisseria
gonorrhoeae) 		PF01116
(F_bP_aldolase) 		5 ALA A 193
GLU A 142
LEU A 146
GLY A 152
LEU A 149
 None
 0.98A 5gtrA-5u4nA:
undetectable		 5gtrA-5u4nA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		5 MET A  74
LEU A  30
LEU A  35
ILE A 376
GLY A 135
 None
 1.14A 5gtrA-5x2qA:
undetectable		 5gtrA-5x2qA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1

(Homo sapiens) 		PF00514
(Arm) 		5 LEU A 149
LEU A 136
LEU A 140
MET A 194
GLY A 158
 None
 1.13A 5gtrA-5xgcA:
undetectable		 5gtrA-5xgcA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Desulfovibrio
gigas) 		no annotation 5 MET A 248
LEU A 245
LEU A 184
ILE A 238
GLY A 235
 None
None
None
None
FAD  A 701 (-3.5A)
 1.07A 5gtrA-5xmjA:
undetectable		 5gtrA-5xmjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xx9 BACTERIOFERRITIN

(Streptomyces
coelicolor) 		no annotation 5 LEU A  19
LEU A  58
ILE A   8
GLY A  67
LEU A  68
 None
 1.08A 5gtrA-5xx9A:
undetectable		 5gtrA-5xx9A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 5 LEU A  58
LEU A 104
LEU A 105
GLY A  44
LEU A  94
 None
None
None
RFH  A 502 ( 4.7A)
None
 1.07A 5gtrA-6c7sA:
undetectable		 5gtrA-6c7sA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Acinetobacter
baumannii) 		no annotation 5 LEU A 484
GLU A 487
ARG A 317
ILE A 535
GLY A 465
 None
 1.02A 5gtrA-6d6kA:
undetectable		 5gtrA-6d6kA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gk6 -

(-) 		no annotation 5 LEU A 359
ALA A 360
GLU A 363
GLY A 288
LEU A 284
 HEM  A 501 ( 4.5A)
HEM  A 501 (-3.5A)
HEM  A 501 ( 4.5A)
None
None
 1.14A 5gtrA-6gk6A:
undetectable		 5gtrA-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ayz UBIQUITIN-CONJUGATIN
G ENZYME RAD6

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		4 LEU A  55
LEU A  92
PHE A  72
LEU A 112
 None
 0.86A 5gtrA-1ayzA:
undetectable		 5gtrA-1ayzA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkd SON OF SEVENLESS-1

(Homo sapiens) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 LEU S 640
PHE S 958
LEU S 613
HIS S 700
 None
 1.04A 5gtrA-1bkdS:
1.6		 5gtrA-1bkdS:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy2 COLLAGEN ALPHA1(XV)
CHAIN

(Mus musculus) 		PF06482
(Endostatin) 		4 LEU A 241
LEU A 244
LEU A 224
HIS A 193
 None
 1.00A 5gtrA-1dy2A:
undetectable		 5gtrA-1dy2A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2

(Homo sapiens) 		PF00145
(DNA_methylase) 		4 LEU A 385
LEU A  74
PHE A 164
LEU A 377
 None
None
None
SAH  A 392 ( 4.7A)
 1.01A 5gtrA-1g55A:
0.0		 5gtrA-1g55A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7k UBIQUITIN-CONJUGATIN
G ENZYME E2 H10

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU A  81
LEU A 118
PHE A  98
LEU A 138
 None
 1.03A 5gtrA-1i7kA:
0.0		 5gtrA-1i7kA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io3 CYTOCHROME C2

(Blastochloris
viridis) 		PF00034
(Cytochrom_C) 		4 LEU A  34
PHE A  35
LEU A  93
HIS A  17
 HEM  A 108 ( 4.8A)
None
None
HEM  A 108 (-3.1A)
 1.05A 5gtrA-1io3A:
undetectable		 5gtrA-1io3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jov HI1317

(Haemophilus
influenzae) 		PF01263
(Aldose_epim) 		4 LEU A   6
LEU A   9
LEU A  37
HIS A  25
 None
 0.97A 5gtrA-1jovA:
undetectable		 5gtrA-1jovA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5a AMIDE SYNTHASE

(Vibrio cholerae) 		PF00668
(Condensation) 		4 LEU A 376
LEU A 219
PHE A 397
LEU A 241
 None
 1.04A 5gtrA-1l5aA:
0.0		 5gtrA-1l5aA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 LEU A 346
LEU A 374
PHE A 350
HIS A 342
 None
 0.96A 5gtrA-1mqqA:
0.0		 5gtrA-1mqqA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9r AGROBACTERIUM
TUMEFACIENS DPS

(Agrobacterium
tumefaciens) 		PF00210
(Ferritin) 		4 LEU A  54
LEU A  43
PHE A  58
LEU A 110
 None
 1.02A 5gtrA-1o9rA:
undetectable		 5gtrA-1o9rA:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 346
LEU A 384
PHE A 404
LEU A 428
HIS A 524
 EST  A   1 (-4.4A)
None
EST  A   1 (-4.9A)
None
EST  A   1 (-3.8A)
 0.33A 5gtrA-1pcgA:
36.2		 5gtrA-1pcgA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxy FIMBRIN-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00307
(CH) 		4 LEU A 137
LEU A 156
LEU A 166
HIS A 132
 None
 0.98A 5gtrA-1pxyA:
undetectable		 5gtrA-1pxyA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 LEU A 408
LEU A 417
LEU A 388
HIS A 395
 None
 1.03A 5gtrA-1serA:
undetectable		 5gtrA-1serA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 LEU A 656
LEU A 501
PHE A 660
LEU A 607
 None
 0.94A 5gtrA-1suvA:
undetectable		 5gtrA-1suvA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 800
LEU A 862
PHE A 681
LEU A 764
 None
 0.95A 5gtrA-1t46A:
undetectable		 5gtrA-1t46A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux4 BNI1 PROTEIN

(Saccharomyces
cerevisiae) 		PF02181
(FH2) 		4 LEU A1565
LEU A1712
PHE A1569
LEU A1591
 None
 0.69A 5gtrA-1ux4A:
undetectable		 5gtrA-1ux4A:
24.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 324
PHE A 382
LEU A 405
HIS A 494
 None
 0.79A 5gtrA-1xb7A:
28.3		 5gtrA-1xb7A:
33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6l UBIQUITIN-CONJUGATIN
G ENZYME E2E2

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU A  52
LEU A  89
PHE A  69
LEU A 109
 None
 0.99A 5gtrA-1y6lA:
undetectable		 5gtrA-1y6lA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A  22
LEU A 132
PHE A 137
LEU A 310
 None
 0.80A 5gtrA-1ykwA:
undetectable		 5gtrA-1ykwA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3d UBIQUITIN-CONJUGATIN
G ENZYME E2 1

(Caenorhabditis
elegans) 		PF00179
(UQ_con) 		4 LEU A  55
LEU A  92
PHE A  72
LEU A 112
 None
 0.93A 5gtrA-1z3dA:
undetectable		 5gtrA-1z3dA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE LARGE
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 LEU A 321
LEU A 302
LEU A 177
HIS A  51
 None
 0.85A 5gtrA-2b24A:
undetectable		 5gtrA-2b24A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bep UBIQUITIN-CONJUGATIN
G ENZYME E2-25 KDA

(Bos taurus) 		PF00179
(UQ_con) 		4 LEU A  58
LEU A  96
PHE A  75
LEU A 116
 None
 1.04A 5gtrA-2bepA:
undetectable		 5gtrA-2bepA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		4 LEU A 225
LEU A 193
PHE A 221
LEU A 181
 None
 0.74A 5gtrA-2e7uA:
undetectable		 5gtrA-2e7uA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fna CONSERVED
HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus) 		PF01637
(ATPase_2) 		4 LEU A 127
LEU A  98
PHE A 123
LEU A  80
 None
 0.95A 5gtrA-2fnaA:
undetectable		 5gtrA-2fnaA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 LEU A 556
LEU A 610
PHE A 473
LEU A 507
 None
 0.85A 5gtrA-2g3nA:
undetectable		 5gtrA-2g3nA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmi UBIQUITIN-CONJUGATIN
G ENZYME E2 13

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		4 LEU A  54
LEU A  91
PHE A  71
LEU A 111
 None
 0.91A 5gtrA-2gmiA:
undetectable		 5gtrA-2gmiA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB

(Methanocaldococcus
jannaschii) 		PF02492
(cobW) 		4 LEU A 210
LEU A 163
PHE A 206
LEU A  49
 None
 0.92A 5gtrA-2hf8A:
undetectable		 5gtrA-2hf8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		4 LEU A  47
PHE A 154
LEU A 156
HIS A  15
 None
 1.02A 5gtrA-2jkyA:
undetectable		 5gtrA-2jkyA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqa CALPAIN 8

(Homo sapiens) 		PF00648
(Peptidase_C2) 		4 LEU A 284
LEU A 232
PHE A 331
LEU A 338
 None
CSO  A 233 ( 4.3A)
None
None
 0.97A 5gtrA-2nqaA:
undetectable		 5gtrA-2nqaA:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 346
LEU A 384
PHE A 404
LEU A 428
HIS A 524
 EST  A 596 (-4.4A)
None
None
None
EST  A 596 (-4.2A)
 0.37A 5gtrA-2ocfA:
34.5		 5gtrA-2ocfA:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtz METHIONINE SYNTHASE
REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 LEU A 328
LEU A 428
PHE A 370
LEU A 441
 None
 1.05A 5gtrA-2qtzA:
undetectable		 5gtrA-2qtzA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0j UBIQUITIN CARRIER
PROTEIN

(Plasmodium
falciparum) 		PF00179
(UQ_con) 		4 LEU A  52
LEU A  89
PHE A  69
LEU A 109
 None
 0.93A 5gtrA-2r0jA:
undetectable		 5gtrA-2r0jA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb6 UBIQUITIN-CONJUGATIN
G ENZYME E2 B

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU A  55
LEU A  92
PHE A  72
LEU A 112
 None
 0.94A 5gtrA-2yb6A:
undetectable		 5gtrA-2yb6A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 LEU A 282
LEU A 331
PHE A 284
LEU A 266
 None
 1.02A 5gtrA-2z7xA:
undetectable		 5gtrA-2z7xA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 LEU A 282
LEU A 334
PHE A 284
LEU A 266
 None
 1.05A 5gtrA-2z7xA:
undetectable		 5gtrA-2z7xA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 411
LEU A 464
PHE A 416
LEU A 450
 None
 1.05A 5gtrA-3b2dA:
undetectable		 5gtrA-3b2dA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzh UBIQUITIN-CONJUGATIN
G ENZYME E2 E1

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU A  98
LEU A 135
PHE A 115
LEU A 155
 None
GOL  A 200 (-3.0A)
None
None
 1.05A 5gtrA-3bzhA:
undetectable		 5gtrA-3bzhA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 128
LEU A  80
PHE A 119
LEU A  90
 None
 0.85A 5gtrA-3ciyA:
undetectable		 5gtrA-3ciyA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqz RESPONSE REGULATOR

(Colwellia
psychrerythraea) 		PF00072
(Response_reg) 		4 LEU A  43
LEU A  99
LEU A  51
HIS A  66
 LEU  A  43 ( 0.6A)
LEU  A  99 ( 0.6A)
LEU  A  51 ( 0.5A)
HIS  A  66 ( 1.0A)
 0.91A 5gtrA-3eqzA:
undetectable		 5gtrA-3eqzA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3err FUSION PROTEIN OF
MICROTUBULE BINDING
DOMAIN FROM MOUSE
CYTOPLASMIC DYNEIN
AND SERYL-TRNA
SYNTHETASE FROM
THERMUS THERMOPHILUS

(Mus musculus;
Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF12777
(MT) 		4 LEU A 408
LEU A 417
LEU A 388
HIS A 395
 None
 0.97A 5gtrA-3errA:
undetectable		 5gtrA-3errA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gri DIHYDROOROTASE

(Staphylococcus
aureus) 		PF01979
(Amidohydro_1) 		4 LEU A 348
LEU A  10
PHE A 330
LEU A 380
 None
 0.98A 5gtrA-3griA:
undetectable		 5gtrA-3griA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 LEU B 478
LEU B 469
PHE B 474
LEU B 771
 None
 1.03A 5gtrA-3h0gB:
undetectable		 5gtrA-3h0gB:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcu UBIQUITIN-CONJUGATIN
G ENZYME E2 N

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU B  54
LEU B  91
PHE B  71
LEU B 111
 None
 0.84A 5gtrA-3hcuB:
undetectable		 5gtrA-3hcuB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA

(Methylobacillus
flagellatus) 		PF08886
(GshA) 		4 LEU A 410
LEU A  56
PHE A 221
LEU A  21
 None
 0.93A 5gtrA-3k1tA:
undetectable		 5gtrA-3k1tA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		4 LEU A 405
LEU A 418
PHE A 245
HIS A  80
 None
 0.87A 5gtrA-3k9dA:
undetectable		 5gtrA-3k9dA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmu ALPHA-PARVIN

(Homo sapiens) 		PF00307
(CH) 		4 LEU B 361
LEU B 303
PHE B 290
LEU B 276
 None
 0.92A 5gtrA-3kmuB:
undetectable		 5gtrA-3kmuB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3le1 PHOSPHOTRANSFERASE
SYSTEM, HPR-RELATED
PROTEINS

(Caldanaerobacter
subterraneus) 		PF00381
(PTS-HPr) 		4 LEU A  80
LEU A  63
PHE A  85
LEU A  14
 None
 0.94A 5gtrA-3le1A:
undetectable		 5gtrA-3le1A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		4 LEU X 643
LEU X 590
PHE X 537
LEU X 605
 None
 1.05A 5gtrA-3lxuX:
undetectable		 5gtrA-3lxuX:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oi8 UNCHARACTERIZED
PROTEIN

(Neisseria
meningitidis) 		PF00571
(CBS) 		4 LEU A 129
LEU A 113
LEU A  73
HIS A 109
 None
None
GOL  A   1 (-4.1A)
None
 1.04A 5gtrA-3oi8A:
undetectable		 5gtrA-3oi8A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfw RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large) 		4 LEU A 275
LEU A 267
PHE A 276
LEU A  84
 None
 0.96A 5gtrA-3qfwA:
undetectable		 5gtrA-3qfwA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swh PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF10540
(Membr_traf_MHD) 		4 LEU A1268
LEU A1275
PHE A1189
LEU A1181
 None
 0.89A 5gtrA-3swhA:
1.5		 5gtrA-3swhA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 LEU A  87
LEU A  39
PHE A  83
LEU A  52
 None
 0.85A 5gtrA-3wy2A:
undetectable		 5gtrA-3wy2A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 LEU A 115
LEU A  67
PHE A 111
LEU A  80
 None
 0.86A 5gtrA-3zo9A:
undetectable		 5gtrA-3zo9A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bh6 APC/C ACTIVATOR
PROTEIN CDH1

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 LEU A 281
LEU A 308
LEU A 277
HIS A 520
 None
 1.05A 5gtrA-4bh6A:
undetectable		 5gtrA-4bh6A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		4 LEU B 310
LEU B 290
PHE B 282
LEU B 263
 None
 1.03A 5gtrA-4ci2B:
undetectable		 5gtrA-4ci2B:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE

(Salmonella
enterica) 		PF01909
(NTP_transf_2)
PF13427
(DUF4111) 		4 LEU A 139
LEU A 134
LEU A  96
HIS A  32
 None
 0.97A 5gtrA-4cs6A:
undetectable		 5gtrA-4cs6A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edn BETA-PARVIN

(Homo sapiens) 		PF00307
(CH) 		4 LEU A 353
LEU A 295
PHE A 282
LEU A 268
 None
 0.99A 5gtrA-4ednA:
undetectable		 5gtrA-4ednA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fai CG5976, ISOFORM B

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		4 LEU A 229
LEU A 226
PHE A 313
HIS A 137
 PBD  A 402 (-4.8A)
None
PBD  A 402 (-3.8A)
None
 0.95A 5gtrA-4faiA:
undetectable		 5gtrA-4faiA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fyc THIOL:DISULFIDE
INTERCHANGE PROTEIN
(DSBC)

(Helicobacter
pylori) 		PF13098
(Thioredoxin_2) 		4 LEU A 184
LEU A 205
PHE A 180
LEU A 171
 None
 0.86A 5gtrA-4fycA:
undetectable		 5gtrA-4fycA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpr UBIQUITIN-CONJUGATIN
G ENZYME FAMILY
PROTEIN

(Entamoeba
histolytica) 		PF00179
(UQ_con) 		4 LEU A  52
LEU A  89
PHE A  69
LEU A 109
 None
 1.04A 5gtrA-4gprA:
undetectable		 5gtrA-4gprA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 LEU A 341
LEU A 323
PHE A 551
LEU A 395
 None
 0.79A 5gtrA-4hozA:
undetectable		 5gtrA-4hozA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5n SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA -
CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG CHIMERIC
CONSTRUCT

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 LEU B 238
LEU B 248
PHE B 237
LEU B 298
 None
 1.01A 5gtrA-4i5nB:
undetectable		 5gtrA-4i5nB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9f GLYCEROL 3-PHOSPHATE
PHOSPHATASE

(Mycobacterium
tuberculosis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 LEU A 254
LEU A 264
LEU A 205
HIS A 258
 None
 0.99A 5gtrA-4i9fA:
undetectable		 5gtrA-4i9fA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		4 LEU A1000
LEU A1030
PHE A 996
LEU A1054
 None
 1.05A 5gtrA-4kf7A:
undetectable		 5gtrA-4kf7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 LEU A 238
LEU A 248
PHE A 237
LEU A 298
 None
 0.91A 5gtrA-4mewA:
undetectable		 5gtrA-4mewA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhp GLUTAMINYL CYCLASE,
PUTATIVE

(Ixodes
scapularis) 		PF04389
(Peptidase_M28) 		4 LEU A 239
LEU A 236
PHE A 317
HIS A 128
 None
 0.97A 5gtrA-4mhpA:
undetectable		 5gtrA-4mhpA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mte ZINC UPTAKE
REGULATION PROTEIN

(Escherichia
coli) 		PF01475
(FUR) 		4 LEU A   9
LEU A  29
PHE A  91
LEU A  70
 None
 1.01A 5gtrA-4mteA:
undetectable		 5gtrA-4mteA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		4 LEU A 494
LEU A 509
PHE A 744
HIS A 526
 None
 0.86A 5gtrA-4nh0A:
undetectable		 5gtrA-4nh0A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN

(Haemophilus
influenzae) 		PF03480
(DctP) 		4 LEU A 109
LEU A  92
PHE A 110
LEU A 120
 None
2UF  A 401 (-4.3A)
None
None
 0.97A 5gtrA-4pbqA:
undetectable		 5gtrA-4pbqA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn5 FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
3

(Escherichia
coli) 		PF02302
(PTS_IIB) 		4 LEU A  62
LEU A   4
PHE A  74
LEU A  49
 None
 1.05A 5gtrA-4tn5A:
undetectable		 5gtrA-4tn5A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uob ENDONUCLEASE III-3

(Deinococcus
radiodurans) 		PF00730
(HhH-GPD) 		4 LEU A 104
LEU A 313
PHE A 100
LEU A 261
 None
SF4  A1329 ( 4.8A)
None
None
 0.93A 5gtrA-4uobA:
undetectable		 5gtrA-4uobA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wva UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		PF01204
(Trehalase) 		4 LEU A 135
LEU A 142
PHE A  59
LEU A  33
 None
 0.93A 5gtrA-4wvaA:
undetectable		 5gtrA-4wvaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xd9 RIBOSOME BIOGENESIS
PROTEIN, PUTATIVE
(AFU_ORTHOLOGUE
AFUA_8G04790)

(Aspergillus
nidulans) 		PF04427
(Brix) 		4 LEU A 171
LEU A 164
PHE A 172
LEU A 206
 None
 0.83A 5gtrA-4xd9A:
undetectable		 5gtrA-4xd9A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14629
(ORC4_C) 		4 LEU D 100
LEU D  88
PHE D 121
LEU D 164
 None
 0.80A 5gtrA-4xgcD:
undetectable		 5gtrA-4xgcD:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yii UBIQUITIN-CONJUGATIN
G ENZYME E2 C

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU U  81
LEU U 118
PHE U  98
LEU U 138
 None
 1.01A 5gtrA-4yiiU:
undetectable		 5gtrA-4yiiU:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Homo sapiens) 		PF04389
(Peptidase_M28) 		4 LEU A 249
LEU A 246
PHE A 325
HIS A 140
 None
 1.01A 5gtrA-4yu9A:
undetectable		 5gtrA-4yu9A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 LEU R 205
LEU R 232
LEU R 201
HIS R 444
 None
 0.98A 5gtrA-5a31R:
undetectable		 5gtrA-5a31R:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4p REPEBODY

(synthetic
construct) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 LEU A 161
LEU A 113
PHE A 152
LEU A 123
 None
 1.03A 5gtrA-5b4pA:
undetectable		 5gtrA-5b4pA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmt UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		no annotation 4 LEU A 133
LEU A 181
PHE A 254
LEU A 214
 None
 0.79A 5gtrA-5bmtA:
undetectable		 5gtrA-5bmtA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brq GLYCOSIDE HYDROLASE
FAMILY 13

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 LEU A  88
LEU A  40
PHE A  84
LEU A  53
 None
 0.99A 5gtrA-5brqA:
undetectable		 5gtrA-5brqA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by8 RPF2

(Aspergillus
nidulans) 		PF04427
(Brix) 		4 LEU A 171
LEU A 164
PHE A 172
LEU A 206
 None
 0.84A 5gtrA-5by8A:
undetectable		 5gtrA-5by8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfl UBIQUITIN-CONJUGATIN
G ENZYME E2 K

(Homo sapiens) 		PF00179
(UQ_con)
PF00627
(UBA) 		4 LEU A  58
LEU A  96
PHE A  75
LEU A 116
 None
GOL  A 301 (-3.5A)
None
None
 1.03A 5gtrA-5dflA:
undetectable		 5gtrA-5dflA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta) 		PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 LEU A 665
LEU A 711
PHE A 670
LEU A 704
 None
 1.03A 5gtrA-5gmhA:
undetectable		 5gtrA-5gmhA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvi UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Danio rerio) 		PF00443
(UCH) 		4 LEU A  82
LEU A 139
PHE A  88
LEU A 169
 None
 0.90A 5gtrA-5gviA:
undetectable		 5gtrA-5gviA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzo UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN

(Chaetomium
thermophilum) 		PF06427
(UDP-g_GGTase) 		4 LEU A 811
LEU A 717
PHE A 828
LEU A 703
 None
 1.05A 5gtrA-5mzoA:
undetectable		 5gtrA-5mzoA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngz UBIQUITIN-CONJUGATIN
G ENZYME E2 T

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU A  53
LEU A  90
PHE A  70
LEU A 114
 None
 1.05A 5gtrA-5ngzA:
undetectable		 5gtrA-5ngzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkz UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA

(Ogataea angusta) 		no annotation 4 LEU A  63
LEU A 123
PHE A  80
LEU A 143
 None
 1.03A 5gtrA-5nkzA:
undetectable		 5gtrA-5nkzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Homo sapiens) 		PF00443
(UCH) 		4 LEU A  86
LEU A 143
PHE A  92
LEU A 173
 None
 1.04A 5gtrA-5ohkA:
undetectable		 5gtrA-5ohkA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojj UBIQUITIN-CONJUGATIN
G ENZYME E2 T

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU A  53
LEU A  90
PHE A  70
LEU A 114
 None
 1.03A 5gtrA-5ojjA:
undetectable		 5gtrA-5ojjA:
18.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 298
PHE A 356
LEU A 380
HIS A 475
 EST  A 601 (-4.1A)
EST  A 601 ( 4.9A)
None
EST  A 601 (-4.4A)
 0.30A 5gtrA-5toaA:
29.9		 5gtrA-5toaA:
59.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 4 LEU A 152
LEU A 184
PHE A 148
LEU A 231
 None
 1.03A 5gtrA-5turA:
undetectable		 5gtrA-5turA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis) 		no annotation 4 LEU A 133
LEU A 157
PHE A  84
LEU A  64
 None
 0.99A 5gtrA-5ufmA:
undetectable		 5gtrA-5ufmA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Homo sapiens) 		PF13191
(AAA_16)
PF14629
(ORC4_C) 		4 LEU C 111
LEU C  99
PHE C 132
LEU C 176
 None
 1.02A 5gtrA-5uj7C:
undetectable		 5gtrA-5uj7C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w99 PBTD

(Planobispora
rosea) 		no annotation 4 LEU A  45
LEU A 107
LEU A  25
HIS A  66
 None
 1.01A 5gtrA-5w99A:
undetectable		 5gtrA-5w99A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides) 		no annotation 4 LEU A 264
LEU A 298
PHE A 344
LEU A 330
 None
 0.95A 5gtrA-5wypA:
undetectable		 5gtrA-5wypA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7u TREHALOSE SYNTHASE

(Thermobaculum
terrenum) 		no annotation 4 LEU A  87
LEU A  39
PHE A  83
LEU A  52
 None
 0.92A 5gtrA-5x7uA:
undetectable		 5gtrA-5x7uA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans) 		no annotation 4 LEU A  88
LEU A  40
PHE A  84
LEU A  53
 None
 1.04A 5gtrA-5ykbA:
undetectable		 5gtrA-5ykbA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2

(Homo sapiens) 		no annotation 4 LEU A 275
PHE A 176
LEU A 137
HIS A 315
 None
 0.97A 5gtrA-6apjA:
undetectable		 5gtrA-6apjA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emo -

(-) 		no annotation 4 LEU A 377
PHE A 476
LEU A 363
HIS A 356
 None
 0.98A 5gtrA-6emoA:
undetectable		 5gtrA-6emoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emr -

(-) 		no annotation 4 LEU A 377
PHE A 488
LEU A 363
HIS A 356
 None
 0.91A 5gtrA-6emrA:
undetectable		 5gtrA-6emrA:
undetectable