SIMILAR PATTERNS OF AMINO ACIDS FOR 5GSN_C_MMZC503_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv5 HYPOTHETICAL PROTEIN
YWQG

(Bacillus
subtilis) 		PF09234
(DUF1963) 		4 TYR A 111
ASN A  67
SER A  69
SER A  80
 None
 1.30A 5gsnC-1pv5A:
0.0		 5gsnC-1pv5A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		4 TYR A 889
ASN A 928
SER A  81
SER A  82
 None
 1.26A 5gsnC-1uf2A:
0.0		 5gsnC-1uf2A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7l PHYCOERYTHROCYANIN
ALPHA CHAIN
PHYCOERYTHROCYANIN
BETA CHAIN

(Mastigocladus
laminosus) 		PF00502
(Phycobilisome) 		4 TYR A  18
ASN B  47
SER B  50
SER B  49
 None
 0.98A 5gsnC-2c7lA:
undetectable		 5gsnC-2c7lA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		4 TYR A  85
ASN A  91
SER A 222
SER A 223
 None
NDP  A 501 ( 3.5A)
NDP  A 501 (-2.9A)
NDP  A 501 (-2.8A)
 0.80A 5gsnC-2gv8A:
35.0		 5gsnC-2gv8A:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 TYR A 520
ASN A 133
SER A 130
SER A 129
 None
 1.32A 5gsnC-3h09A:
0.0		 5gsnC-3h09A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l84 TRANSKETOLASE

(Campylobacter
jejuni) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 TYR A 600
ASN A 627
SER A 623
SER A 621
 None
 1.14A 5gsnC-3l84A:
2.7		 5gsnC-3l84A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vis ESTERASE

(Thermobifida
alba) 		PF12740
(Chlorophyllase2) 		4 TYR A  83
ASN A 156
SER A 152
SER A 151
 None
 1.48A 5gsnC-3visA:
1.2		 5gsnC-3visA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ar9 COLLAGENASE COLT

(Clostridium
tetani) 		PF01752
(Peptidase_M9) 		4 TYR A 665
ASN A 676
SER A 669
SER A 668
 None
 1.48A 5gsnC-4ar9A:
0.8		 5gsnC-4ar9A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00659
(POLO_box) 		4 TYR A 645
ASN A 671
SER A 667
SER A 666
 None
 1.27A 5gsnC-4xb0A:
0.0		 5gsnC-4xb0A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5buo AMYLOID BETA A4
PROTEIN

(Homo sapiens) 		PF12925
(APP_E2) 		4 TYR A 401
ASN A 475
SER A 471
SER A 469
 None
 1.40A 5gsnC-5buoA:
undetectable		 5gsnC-5buoA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE

(Astrosporangium
hypotensionis) 		PF01432
(Peptidase_M3) 		4 TYR A  34
ASN A  84
SER A  87
SER A  86
 None
None
K26  A1005 ( 4.2A)
None
 1.23A 5gsnC-5l44A:
1.1		 5gsnC-5l44A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m76 LIGHT CHAIN DIMER

(Homo sapiens) 		no annotation 4 TYR A  32
ASN A  25
SER A  94
SER A  93
 None
 1.46A 5gsnC-5m76A:
undetectable		 5gsnC-5m76A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr7 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Vibrio cholerae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 TYR A 199
ASN A 218
SER A 245
SER A 246
 None
 1.36A 5gsnC-5tr7A:
undetectable		 5gsnC-5tr7A:
23.26