SIMILAR PATTERNS OF AMINO ACIDS FOR 5GSN_A_MMZA503_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avb ARCELIN-1

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		3 ASN A  68
SER A  66
SER A 222
 NAG  A 400 (-1.8A)
NAG  A 400 (-3.1A)
None
 0.66A 5gsnA-1avbA:
undetectable		 5gsnA-1avbA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avb ARCELIN-1

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		3 ASN A 224
SER A 222
SER A  66
 None
None
NAG  A 400 (-3.1A)
 0.78A 5gsnA-1avbA:
undetectable		 5gsnA-1avbA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee6 PECTATE LYASE

(Bacillus sp.
KSM-P15) 		PF03211
(Pectate_lyase) 		3 ASN A 149
SER A 151
SER A 175
 None
 0.71A 5gsnA-1ee6A:
undetectable		 5gsnA-1ee6A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 ASN A 182
SER A 109
SER A 108
 None
 0.77A 5gsnA-1gg4A:
2.9		 5gsnA-1gg4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		3 ASN A 504
SER A 506
SER A 499
 None
 0.72A 5gsnA-1j0nA:
0.0		 5gsnA-1j0nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1juh QUERCETIN
2,3-DIOXYGENASE

(Aspergillus
japonicus) 		no annotation 3 ASN A 248
SER A 325
SER A 324
 NAG  A 504 (-1.9A)
NAG  A 504 (-3.1A)
None
 0.74A 5gsnA-1juhA:
undetectable		 5gsnA-1juhA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kr1 HEVAMINE A

(Hevea
brasiliensis) 		PF00704
(Glyco_hydro_18) 		3 ASN A 103
SER A 111
SER A 110
 None
 0.66A 5gsnA-1kr1A:
0.0		 5gsnA-1kr1A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mf1 ADENYLOSUCCINATE
SYNTHETASE

(Mus musculus) 		PF00709
(Adenylsucc_synt) 		3 ASN A 256
SER A 273
SER A 272
 AMP  A 459 (-3.9A)
None
None
 0.75A 5gsnA-1mf1A:
undetectable		 5gsnA-1mf1A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 ASN A 316
SER A 368
SER A 367
 None
 0.71A 5gsnA-1opkA:
0.0		 5gsnA-1opkA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osn THYMIDINE KINASE

(Human
alphaherpesvirus
3) 		PF00693
(Herpes_TK) 		3 ASN A 327
SER A 323
SER A 322
 None
 0.75A 5gsnA-1osnA:
undetectable		 5gsnA-1osnA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9b ADENYLOSUCCINATE
SYNTHETASE

(Plasmodium
falciparum) 		PF00709
(Adenylsucc_synt) 		3 ASN A 232
SER A 249
SER A 248
 IMO  A1601 (-3.7A)
None
None
 0.64A 5gsnA-1p9bA:
undetectable		 5gsnA-1p9bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgi PROTEIN
(CHITOSANASE)

(Bacillus
circulans) 		PF01374
(Glyco_hydro_46) 		3 ASN A 205
SER A 196
SER A 195
 None
 0.79A 5gsnA-1qgiA:
undetectable		 5gsnA-1qgiA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 ASN A 718
SER A 721
SER A 720
 None
 0.79A 5gsnA-1r8wA:
undetectable		 5gsnA-1r8wA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqw SACCHAROMYCES
CEREVISIAE NIP7P
HOMOLOG

(Homo sapiens) 		PF03657
(UPF0113) 		3 ASN A 124
SER A 126
SER A 149
 None
 0.49A 5gsnA-1sqwA:
undetectable		 5gsnA-1sqwA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te5 CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF13230
(GATase_4) 		3 ASN A 109
SER A 187
SER A 186
 None
 0.76A 5gsnA-1te5A:
undetectable		 5gsnA-1te5A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgh UBIQUITIN-LIKE 3

(Mus musculus) 		PF13881
(Rad60-SLD_2) 		3 ASN A  77
SER A  38
SER A  40
 None
 0.68A 5gsnA-1wghA:
undetectable		 5gsnA-1wghA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9c SULFITE OXIDASE

(Gallus gallus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		3 ASN A 437
SER A 435
SER A 434
 None
 0.74A 5gsnA-2a9cA:
undetectable		 5gsnA-2a9cA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 ASN A 244
SER A 213
SER A 214
 None
 0.73A 5gsnA-2atcA:
2.9		 5gsnA-2atcA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Helicobacter
pylori) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		3 ASN A 141
SER A 100
SER A 101
 None
 0.78A 5gsnA-2b7nA:
undetectable		 5gsnA-2b7nA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv2 CIONA
BETAGAMMA-CRYSTALLIN

(Ciona
intestinalis) 		PF00030
(Crystall) 		3 ASN A  26
SER A  78
SER A  79
 None
CA  A 102 (-2.2A)
None
 0.77A 5gsnA-2bv2A:
undetectable		 5gsnA-2bv2A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cit ENDOGLUCANASE H

(Ruminiclostridium
thermocellum) 		PF02156
(Glyco_hydro_26) 		3 ASN A 126
SER A 123
SER A 122
 None
 0.74A 5gsnA-2citA:
undetectable		 5gsnA-2citA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		3 ASN A 303
SER A 349
SER A 350
 None
 0.74A 5gsnA-2fgeA:
undetectable		 5gsnA-2fgeA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)

(West Nile virus) 		PF00972
(Flavi_NS5) 		3 ASN A 782
SER A 890
SER A 889
 None
 0.76A 5gsnA-2hcsA:
undetectable		 5gsnA-2hcsA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ASN A 297
SER A 349
SER A 348
 None
 0.63A 5gsnA-2hz0A:
undetectable		 5gsnA-2hz0A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4m ENDOGLUCANASE 45A

(Piromyces equi) 		PF02013
(CBM_10) 		3 ASN A  57
SER A  18
SER A  19
 None
 0.78A 5gsnA-2j4mA:
undetectable		 5gsnA-2j4mA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE

(Macaca
fascicularis) 		PF01408
(GFO_IDH_MocA) 		3 ASN X1278
SER X1015
SER X1014
 None
 0.74A 5gsnA-2o4uX:
4.2		 5gsnA-2o4uX:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 ASN A  57
SER A  66
SER A  59
 None
 0.71A 5gsnA-2p2mA:
2.5		 5gsnA-2p2mA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkq GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
B

(Spinacia
oleracea) 		PF00044
(Gp_dh_N)
PF02672
(CP12)
PF02800
(Gp_dh_C) 		3 ASN O 152
SER O 289
SER O 290
 None
 0.77A 5gsnA-2pkqO:
1.6		 5gsnA-2pkqO:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqu BETA-FRUCTOFURANOSID
ASE

(Arabidopsis
thaliana) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 ASN A 460
SER A 455
SER A 454
 None
 0.71A 5gsnA-2qquA:
undetectable		 5gsnA-2qquA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzg CONSERVED
UNCHARACTERIZED
ARCHAEAL PROTEIN

(Methanococcus
maripaludis) 		PF03685
(UPF0147) 		3 ASN A  15
SER A  18
SER A  17
 None
 0.78A 5gsnA-2qzgA:
undetectable		 5gsnA-2qzgA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rs7 ATP-DEPENDENT RNA
HELICASE A

(Mus musculus) 		PF00035
(dsrm) 		3 ASN A 182
SER A 263
SER A 262
 None
 0.54A 5gsnA-2rs7A:
undetectable		 5gsnA-2rs7A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2

(Homo sapiens) 		PF00709
(Adenylsucc_synt) 		3 ASN A 255
SER A 272
SER A 271
 None
 0.68A 5gsnA-2v40A:
undetectable		 5gsnA-2v40A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		3 ASN A  90
SER A  64
SER A  65
 None
 0.65A 5gsnA-2v5dA:
2.4		 5gsnA-2v5dA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN

(Bacteroides
fragilis) 		PF00210
(Ferritin) 		3 ASN A 110
SER A 113
SER A 112
 None
 0.70A 5gsnA-2vzbA:
undetectable		 5gsnA-2vzbA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zle PROTEASE DO

(Escherichia
coli) 		PF00595
(PDZ)
PF13365
(Trypsin_2) 		3 ASN A 324
SER A 320
SER A 319
 None
 0.67A 5gsnA-2zleA:
undetectable		 5gsnA-2zleA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4l DNA MISMATCH REPAIR
PROTEIN PMS1

(Saccharomyces
cerevisiae) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		3 ASN A 245
SER A 248
SER A 247
 None
 0.72A 5gsnA-3h4lA:
undetectable		 5gsnA-3h4lA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho6 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80) 		3 ASN A 200
SER A 234
SER A 233
 None
 0.77A 5gsnA-3ho6A:
undetectable		 5gsnA-3ho6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htn PUTATIVE DNA BINDING
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF03479
(DUF296) 		3 ASN A 120
SER A 122
SER A  79
 None
 0.73A 5gsnA-3htnA:
undetectable		 5gsnA-3htnA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz2 BETA/GAMA CRYSTALLIN
FAMILY PROTEIN

(Methanosarcina
acetivorans) 		PF00030
(Crystall) 		3 ASN A  12
SER A  66
SER A  67
 None
 0.71A 5gsnA-3hz2A:
undetectable		 5gsnA-3hz2A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 C381 TURRET PROTEIN

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 3 ASN P 196
SER P 214
SER P 215
 None
 0.68A 5gsnA-3j31P:
undetectable		 5gsnA-3j31P:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw3 ALANINE RACEMASE

(Bartonella
henselae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 ASN A 178
SER A 186
SER A 185
 None
 0.63A 5gsnA-3kw3A:
1.1		 5gsnA-3kw3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		3 ASN B 317
SER B 329
SER B 328
 None
 0.72A 5gsnA-3m2rB:
undetectable		 5gsnA-3m2rB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		3 ASN A 694
SER A 737
SER A 736
 None
 0.63A 5gsnA-3m62A:
undetectable		 5gsnA-3m62A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mog PROBABLE
3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Escherichia
coli) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 ASN A 192
SER A 121
SER A 122
 None
 0.46A 5gsnA-3mogA:
undetectable		 5gsnA-3mogA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2o BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF02784
(Orn_Arg_deC_N) 		3 ASN A 235
SER A 231
SER A 229
 None
 0.70A 5gsnA-3n2oA:
undetectable		 5gsnA-3n2oA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz8 MOUSE ANTI V3
ANTIBODY 7C8 FAB,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASN A  86
SER A  82
SER A  82
 None
 0.77A 5gsnA-3nz8A:
undetectable		 5gsnA-3nz8A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2

(Saccharomyces
cerevisiae) 		PF10193
(Telomere_reg-2) 		3 ASN A 273
SER A 276
SER A 275
 None
 0.76A 5gsnA-3o4zA:
undetectable		 5gsnA-3o4zA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obv PROTEIN DIAPHANOUS
HOMOLOG 1

(Mus musculus) 		PF02181
(FH2)
PF06345
(Drf_DAD) 		3 ASN E 955
SER E 958
SER E 957
 None
 0.71A 5gsnA-3obvE:
undetectable		 5gsnA-3obvE:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p6l SUGAR PHOSPHATE
ISOMERASE/EPIMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		3 ASN A 157
SER A 183
SER A 154
 None
 0.74A 5gsnA-3p6lA:
undetectable		 5gsnA-3p6lA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qa8 MGC80376 PROTEIN

(Xenopus laevis) 		PF00069
(Pkinase) 		3 ASN A  72
SER A 131
SER A 130
 None
 0.74A 5gsnA-3qa8A:
undetectable		 5gsnA-3qa8A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk9 MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM44

(Saccharomyces
cerevisiae) 		PF04280
(Tim44) 		3 ASN A 248
SER A 397
SER A 427
 None
 0.73A 5gsnA-3qk9A:
undetectable		 5gsnA-3qk9A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg0 CALRETICULIN

(Mus musculus) 		PF00262
(Calreticulin) 		3 ASN A 129
SER A 310
SER A  85
 None
 0.76A 5gsnA-3rg0A:
undetectable		 5gsnA-3rg0A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		3 ASN A  93
SER A 119
SER A 118
 K  A 444 ( 3.7A)
None
None
 0.63A 5gsnA-3tr1A:
undetectable		 5gsnA-3tr1A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 ASN A 261
SER A 259
SER A 154
 None
 0.70A 5gsnA-3tz6A:
3.0		 5gsnA-3tz6A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ult ICE
RECRYSTALLIZATION
INHIBITION
PROTEIN-LIKE PROTEIN

(Lolium perenne) 		no annotation 3 ASN A  73
SER A  75
SER A  61
 None
 0.78A 5gsnA-3ultA:
undetectable		 5gsnA-3ultA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		3 ASN A 805
SER A 657
SER A 658
 None
 0.58A 5gsnA-4c4vA:
undetectable		 5gsnA-4c4vA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cn8 PROXIMAL THREAD
MATRIX PROTEIN 1

(Mytilus
galloprovincialis) 		PF00092
(VWA) 		3 ASN A 218
SER A 411
SER A 412
 None
 0.62A 5gsnA-4cn8A:
3.0		 5gsnA-4cn8A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddd IMMUNOGENIC PROTEIN

(Ehrlichia
chaffeensis) 		PF16868
(NMT1_3) 		3 ASN A 205
SER A 182
SER A 183
 None
 0.77A 5gsnA-4dddA:
undetectable		 5gsnA-4dddA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtv GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT ALPHA

(Rattus
norvegicus) 		PF01239
(PPTA) 		3 ASN A 177
SER A 180
SER A 179
 None
 0.75A 5gsnA-4gtvA:
undetectable		 5gsnA-4gtvA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)

(Geobacillus
kaustophilus) 		PF00854
(PTR2) 		3 ASN A 138
SER A 141
SER A 140
 None
 0.73A 5gsnA-4ikvA:
undetectable		 5gsnA-4ikvA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1

(Caenorhabditis
elegans) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 ASN A 203
SER A 132
SER A 133
 None
 0.54A 5gsnA-4j0eA:
4.0		 5gsnA-4j0eA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		3 ASN A 622
SER A 625
SER A 624
 None
 0.78A 5gsnA-4kf7A:
undetectable		 5gsnA-4kf7A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3a INTERNALIN K

(Listeria
monocytogenes) 		no annotation 3 ASN A 200
SER A 198
SER A 175
 None
 0.65A 5gsnA-4l3aA:
undetectable		 5gsnA-4l3aA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on3 SORTING NEXIN-10

(Homo sapiens) 		PF00787
(PX) 		3 ASN A  67
SER A 116
SER A 115
 None
 0.64A 5gsnA-4on3A:
undetectable		 5gsnA-4on3A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ope NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 ASN A4421
SER A4423
SER A4424
 None
 0.71A 5gsnA-4opeA:
undetectable		 5gsnA-4opeA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1n 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Clostridium
butyricum) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 ASN A 188
SER A 117
SER A 118
 None
 0.55A 5gsnA-4r1nA:
3.7		 5gsnA-4r1nA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 ASN A 322
SER A 293
SER A 264
 EDO  A 506 (-3.8A)
None
None
 0.71A 5gsnA-4r5dA:
undetectable		 5gsnA-4r5dA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 ASN A 436
SER A 407
SER A 378
 None
SO4  A 505 ( 3.9A)
None
 0.73A 5gsnA-4r5dA:
undetectable		 5gsnA-4r5dA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4toq CLASS III CHITINASE

(Punica granatum) 		PF00704
(Glyco_hydro_18) 		3 ASN A 103
SER A 111
SER A 110
 None
 0.69A 5gsnA-4toqA:
undetectable		 5gsnA-4toqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsh SURFACE PROTEIN
ADHESIN

(Streptococcus
mutans) 		PF16364
(Antigen_C) 		3 ASN B1335
SER B1486
SER B1485
 None
 0.79A 5gsnA-4tshB:
undetectable		 5gsnA-4tshB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3j PROTEIN STU2

(Saccharomyces
cerevisiae) 		no annotation 3 ASN C 455
SER C 452
SER C 451
 None
 0.78A 5gsnA-4u3jC:
undetectable		 5gsnA-4u3jC:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 3 ASN B 316
SER B 368
SER B 367
 None
 0.68A 5gsnA-4xeyB:
undetectable		 5gsnA-4xeyB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwu INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH) 		3 ASN A 469
SER A  52
SER A  53
 None
 0.72A 5gsnA-4xwuA:
undetectable		 5gsnA-4xwuA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcq FIBRONECTIN-BINDING
PROTEIN

(Streptococcus
equi) 		PF08341
(TED) 		3 ASN D 120
SER D 123
SER D 122
 None
 0.68A 5gsnA-5dcqD:
undetectable		 5gsnA-5dcqD:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASN L 148
SER L 121
SER L 150
 None
 0.68A 5gsnA-5eorL:
undetectable		 5gsnA-5eorL:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcu JR4 FAB LIGHT CHAIN

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASN L  27
SER L  69
SER L  70
 None
 0.77A 5gsnA-5fcuL:
undetectable		 5gsnA-5fcuL:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 PUTATIVE LIPOPROTEIN
SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug)
PF12771
(SusD-like_2) 		3 ASN A 301
SER B 437
SER B 436
 None
 0.77A 5gsnA-5fq6A:
undetectable		 5gsnA-5fq6A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fre EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF02973
(Sialidase) 		3 ASN A  11
SER A  14
SER A  15
 None
 0.76A 5gsnA-5freA:
undetectable		 5gsnA-5freA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gm3 ENDOGLUCANASE-1

(Aspergillus
aculeatus) 		PF01670
(Glyco_hydro_12) 		3 ASN A  38
SER A  48
SER A 212
 None
 0.78A 5gsnA-5gm3A:
undetectable		 5gsnA-5gm3A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 TOLL-LIKE RECEPTOR 3

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		3 ASN A 230
SER A 205
SER A 179
 None
 0.64A 5gsnA-5gs0A:
undetectable		 5gsnA-5gs0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A

(Clostridium
perfringens) 		PF03496
(ADPrib_exo_Tox) 		3 ASN A 279
SER A 282
SER A 281
 None
 0.78A 5gsnA-5h04A:
undetectable		 5gsnA-5h04A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5v FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2

(Escherichia
coli) 		PF02465
(FliD_N)
PF07195
(FliD_C) 		3 ASN A 189
SER A 237
SER A 238
 None
 0.51A 5gsnA-5h5vA:
undetectable		 5gsnA-5h5vA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5w FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2

(Escherichia
coli) 		PF07195
(FliD_C)
PF07196
(Flagellin_IN) 		3 ASN A 189
SER A 237
SER A 238
 None
 0.44A 5gsnA-5h5wA:
undetectable		 5gsnA-5h5wA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i84 PHOSPHATE-BINDING
PROTEIN PSTS

(Xanthomonas
citri) 		PF12849
(PBP_like_2) 		3 ASN A 201
SER A 163
SER A  62
 None
 0.78A 5gsnA-5i84A:
undetectable		 5gsnA-5i84A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 ASN A 714
SER A 716
SER A 719
 NAG  A1012 (-1.9A)
None
None
 0.78A 5gsnA-5j6sA:
undetectable		 5gsnA-5j6sA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnb POLY(A) RNA
POLYMERASE GLD-2

(Caenorhabditis
elegans) 		PF03828
(PAP_assoc) 		3 ASN A 602
SER A 595
SER A 596
 SO4  A1001 (-3.5A)
SO4  A1001 ( 2.4A)
None
 0.55A 5gsnA-5jnbA:
undetectable		 5gsnA-5jnbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kis RHS2

(Yersinia
entomophaga) 		no annotation 3 ASN B  86
SER B  89
SER B 104
 None
 0.78A 5gsnA-5kisB:
undetectable		 5gsnA-5kisB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		3 ASN A 726
SER A 757
SER A 758
 None
 0.62A 5gsnA-5l5gA:
undetectable		 5gsnA-5l5gA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5n PLEXIN-A4

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		3 ASN A 725
SER A 756
SER A 757
 ASN  A 725 ( 0.6A)
SER  A 756 ( 0.0A)
SER  A 757 ( 0.0A)
 0.63A 5gsnA-5l5nA:
undetectable		 5gsnA-5l5nA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc9 LAMININ SUBUNIT
ALPHA-1

(Mus musculus) 		PF00054
(Laminin_G_1)
PF06009
(Laminin_II) 		3 ASN A2468
SER A2314
SER A2315
 None
 0.61A 5gsnA-5mc9A:
undetectable		 5gsnA-5mc9A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 3 ASN A 161
SER A 166
SER A 165
 None
 0.79A 5gsnA-5n7qA:
undetectable		 5gsnA-5n7qA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 ASN A 469
SER A  52
SER A  53
 None
 0.79A 5gsnA-5tc3A:
undetectable		 5gsnA-5tc3A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4l ADENYLOSUCCINATE
LYASE

(Cryptococcus
neoformans) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		3 ASN A 178
SER A 250
SER A 249
 None
 0.63A 5gsnA-5v4lA:
undetectable		 5gsnA-5v4lA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wix P-47 PROTEIN

(Clostridium
botulinum) 		no annotation 3 ASN A   2
SER A 209
SER A 208
 None
 0.75A 5gsnA-5wixA:
undetectable		 5gsnA-5wixA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 3 ASN A 662
SER A 636
SER A 606
 None
 0.78A 5gsnA-5y3jA:
undetectable		 5gsnA-5y3jA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d7a PERFORIN-LIKE
PROTEIN 1

(Toxoplasma
gondii) 		no annotation 3 ASN A 862
SER A 891
SER A 890
 None
 0.78A 5gsnA-6d7aA:
undetectable		 5gsnA-6d7aA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6df3 -

(-) 		no annotation 3 ASN H 110
SER H  76
SER H  80
 None
 0.77A 5gsnA-6df3H:
undetectable		 5gsnA-6df3H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ey4 GLDM

(Flavobacterium
johnsoniae) 		no annotation 3 ASN A  47
SER A  50
SER A  49
 None
 0.79A 5gsnA-6ey4A:
undetectable		 5gsnA-6ey4A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 3 ASN A1886
SER A 835
SER A 836
 None
 0.79A 5gsnA-6ez8A:
undetectable		 5gsnA-6ez8A:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpd PROTEIN AB21

(Agaricus
bisporus) 		no annotation 3 ASN A 143
SER A 146
SER A 145
 None
 0.67A 5gsnA-6fpdA:
undetectable		 5gsnA-6fpdA:
11.65