SIMILAR PATTERNS OF AMINO ACIDS FOR 5GS4_A_ESTA603_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0c SULFURTRANSFERASE

(Azotobacter
vinelandii) 		PF00581
(Rhodanese) 		4 LEU A 102
LEU A 141
LEU A  69
PHE A  98
 None
 0.92A 5gs4A-1e0cA:
undetectable		 5gs4A-1e0cA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Thermotoga
maritima) 		PF01380
(SIS) 		4 LEU A  91
LEU A  66
PHE A  93
LEU A 162
 None
 1.01A 5gs4A-1j5xA:
0.0		 5gs4A-1j5xA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		4 LEU A 423
LEU A 440
LEU A 437
LEU A 326
 None
 0.66A 5gs4A-1jqoA:
0.0		 5gs4A-1jqoA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldk CULLIN HOMOLOG

(Homo sapiens) 		PF00888
(Cullin) 		4 LEU A 279
LEU A 237
PHE A 232
LEU A 184
 None
 0.99A 5gs4A-1ldkA:
0.0		 5gs4A-1ldkA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 LEU A 346
LEU A 374
PHE A 350
HIS A 342
 None
 0.99A 5gs4A-1mqqA:
undetectable		 5gs4A-1mqqA:
15.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 346
LEU A 384
LEU A 387
PHE A 404
LEU A 428
HIS A 524
 EST  A   1 (-4.4A)
None
EST  A   1 (-4.0A)
EST  A   1 (-4.9A)
None
EST  A   1 (-3.8A)
 0.19A 5gs4A-1pcgA:
37.6		 5gs4A-1pcgA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjb L-ALANINE
DEHYDROGENASE

(Phormidium
lapideum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 LEU A 323
LEU A 317
PHE A  91
LEU A 128
 None
 0.92A 5gs4A-1pjbA:
0.0		 5gs4A-1pjbA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		4 LEU A 363
LEU A 380
LEU A 377
LEU A 286
 None
 0.78A 5gs4A-1qb4A:
0.6		 5gs4A-1qb4A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		4 LEU B1707
LEU B1792
LEU B1790
HIS B1630
 None
 0.97A 5gs4A-1sddB:
undetectable		 5gs4A-1sddB:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sj8 TALIN 1

(Mus musculus) 		PF09141
(Talin_middle) 		4 LEU A 594
LEU A 513
LEU A 609
LEU A 651
 None
 0.94A 5gs4A-1sj8A:
1.4		 5gs4A-1sj8A:
22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 324
LEU A 365
PHE A 382
LEU A 405
HIS A 494
 None
 0.71A 5gs4A-1xb7A:
28.5		 5gs4A-1xb7A:
33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfc ALANINE RACEMASE

(Mycobacterium
tuberculosis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A 152
LEU A 114
LEU A 111
PHE A 148
 None
 0.97A 5gs4A-1xfcA:
undetectable		 5gs4A-1xfcA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqs HSPBP1 PROTEIN

(Homo sapiens) 		PF08609
(Fes1) 		4 LEU A 193
LEU A 215
PHE A 226
LEU A 253
 None
 0.89A 5gs4A-1xqsA:
undetectable		 5gs4A-1xqsA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A  22
LEU A 132
PHE A 137
LEU A 310
 None
 0.77A 5gs4A-1ykwA:
undetectable		 5gs4A-1ykwA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE LARGE
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 LEU A 321
LEU A 302
LEU A 177
HIS A  51
 None
 0.94A 5gs4A-2b24A:
undetectable		 5gs4A-2b24A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bac PUTATIVE
AMINOOXIDASE

(Cutibacterium
acnes) 		PF01593
(Amino_oxidase) 		4 LEU A 151
LEU A 117
LEU A 120
LEU A 141
 None
 0.84A 5gs4A-2bacA:
undetectable		 5gs4A-2bacA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		4 LEU A 557
LEU A 428
LEU A 517
HIS A 584
 None
 0.92A 5gs4A-2bxyA:
undetectable		 5gs4A-2bxyA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzm FAS-ASSOCIATED
FACTOR 1

(Homo sapiens) 		no annotation 4 LEU A  68
LEU A  25
LEU A  10
LEU A  76
 None
 0.87A 5gs4A-2dzmA:
undetectable		 5gs4A-2dzmA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eez ALANINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 LEU A 322
LEU A 316
PHE A  90
LEU A 127
 None
 0.96A 5gs4A-2eezA:
undetectable		 5gs4A-2eezA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 LEU A 325
LEU A 319
PHE A 462
LEU A 449
 None
 0.90A 5gs4A-2fgeA:
undetectable		 5gs4A-2fgeA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmi UBIQUITIN-CONJUGATIN
G ENZYME E2 13

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		4 LEU A  54
LEU A  91
PHE A  71
LEU A 111
 None
 0.94A 5gs4A-2gmiA:
undetectable		 5gs4A-2gmiA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB

(Methanocaldococcus
jannaschii) 		PF02492
(cobW) 		4 LEU A 210
LEU A 163
PHE A 206
LEU A  49
 None
 0.94A 5gs4A-2hf8A:
undetectable		 5gs4A-2hf8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 LEU A 242
LEU A 271
LEU A 268
HIS A 246
 None
 0.97A 5gs4A-2id5A:
undetectable		 5gs4A-2id5A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 LEU A 349
LEU A 774
PHE A 341
LEU A 285
 None
 0.97A 5gs4A-2iukA:
undetectable		 5gs4A-2iukA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knh PROTEIN CBFA2T1

(Homo sapiens) 		PF07531
(TAFH) 		4 LEU A 281
LEU A 299
PHE A 323
LEU A 333
 None
 0.91A 5gs4A-2knhA:
undetectable		 5gs4A-2knhA:
19.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 346
LEU A 384
LEU A 387
PHE A 404
LEU A 428
HIS A 524
 EST  A 596 (-4.4A)
None
EST  A 596 ( 4.2A)
None
None
EST  A 596 (-4.2A)
 0.30A 5gs4A-2ocfA:
35.5		 5gs4A-2ocfA:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		4 LEU A 191
LEU A 234
PHE A 193
LEU A 200
 None
 0.97A 5gs4A-2omvA:
undetectable		 5gs4A-2omvA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtz METHIONINE SYNTHASE
REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 LEU A 328
LEU A 425
PHE A 370
LEU A 441
 None
 0.83A 5gs4A-2qtzA:
undetectable		 5gs4A-2qtzA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtz METHIONINE SYNTHASE
REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		5 LEU A 328
LEU A 428
LEU A 425
PHE A 370
LEU A 445
 None
 1.35A 5gs4A-2qtzA:
undetectable		 5gs4A-2qtzA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8s CLATHRIN INTERACTOR
1

(Homo sapiens) 		PF01417
(ENTH) 		4 LEU E  86
LEU E  89
PHE E  57
HIS E 104
 None
None
None
GOL  E1159 (-4.2A)
 0.78A 5gs4A-2v8sE:
undetectable		 5gs4A-2v8sE:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4n UNCHARACTERIZED
PROTEIN DR_0571

(Deinococcus
radiodurans) 		PF01266
(DAO) 		4 LEU A 151
LEU A 276
LEU A 324
LEU A 336
 None
 0.99A 5gs4A-3c4nA:
undetectable		 5gs4A-3c4nA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 128
LEU A  80
PHE A 119
LEU A  90
 None
 0.86A 5gs4A-3ciyA:
undetectable		 5gs4A-3ciyA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dja PROTEIN CT_858

(Chlamydia
trachomatis) 		PF03572
(Peptidase_S41) 		4 LEU A  43
LEU A  49
PHE A  97
LEU A  68
 None
 0.80A 5gs4A-3djaA:
undetectable		 5gs4A-3djaA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkw DNR PROTEIN

(Pseudomonas
aeruginosa) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 LEU A 120
LEU A 117
PHE A  53
LEU A  28
 None
 0.84A 5gs4A-3dkwA:
undetectable		 5gs4A-3dkwA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e73 LANC-LIKE PROTEIN 1

(Homo sapiens) 		PF05147
(LANC_like) 		4 LEU A  28
LEU A 387
PHE A 382
LEU A 333
 None
 0.81A 5gs4A-3e73A:
undetectable		 5gs4A-3e73A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqz RESPONSE REGULATOR

(Colwellia
psychrerythraea) 		PF00072
(Response_reg) 		4 LEU A  43
LEU A  99
LEU A  51
HIS A  66
 LEU  A  43 ( 0.6A)
LEU  A  99 ( 0.6A)
LEU  A  51 ( 0.5A)
HIS  A  66 ( 1.0A)
 0.93A 5gs4A-3eqzA:
undetectable		 5gs4A-3eqzA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy4 6-4 PHOTOLYASE

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 LEU A 296
LEU A 299
PHE A 144
LEU A 165
 None
FAD  A 900 ( 4.9A)
None
None
 0.78A 5gs4A-3fy4A:
undetectable		 5gs4A-3fy4A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gri DIHYDROOROTASE

(Staphylococcus
aureus) 		PF01979
(Amidohydro_1) 		4 LEU A 348
LEU A  10
PHE A 330
LEU A 380
 None
 0.78A 5gs4A-3griA:
undetectable		 5gs4A-3griA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9p PUTATIVE
TRIPHOSPHORIBOSYL-DE
PHOSPHO-COA SYNTHASE

(Archaeoglobus
fulgidus) 		PF01874
(CitG) 		4 LEU A 262
LEU A  94
LEU A  91
LEU A 177
 None
 0.80A 5gs4A-3h9pA:
undetectable		 5gs4A-3h9pA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcu UBIQUITIN-CONJUGATIN
G ENZYME E2 N

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU B  54
LEU B  91
PHE B  71
LEU B 111
 None
 0.88A 5gs4A-3hcuB:
undetectable		 5gs4A-3hcuB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjh TRANSCRIPTION-REPAIR
-COUPLING FACTOR

(Escherichia
coli) 		no annotation 4 LEU A 272
LEU A 327
PHE A 276
LEU A 282
 None
 1.00A 5gs4A-3hjhA:
undetectable		 5gs4A-3hjhA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		4 LEU A 405
LEU A 418
PHE A 245
HIS A  80
 None
 0.80A 5gs4A-3k9dA:
undetectable		 5gs4A-3k9dA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmu ALPHA-PARVIN

(Homo sapiens) 		PF00307
(CH) 		4 LEU B 361
LEU B 303
PHE B 290
LEU B 276
 None
 0.86A 5gs4A-3kmuB:
undetectable		 5gs4A-3kmuB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3le1 PHOSPHOTRANSFERASE
SYSTEM, HPR-RELATED
PROTEINS

(Caldanaerobacter
subterraneus) 		PF00381
(PTS-HPr) 		4 LEU A  80
LEU A  63
PHE A  85
LEU A  14
 None
 1.00A 5gs4A-3le1A:
undetectable		 5gs4A-3le1A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mlg 2X CHIMERA OF
HELICOBACTER PYLORI
PROTEIN HP0242

(Helicobacter
pylori) 		PF09442
(DUF2018) 		4 LEU A  43
LEU A 130
LEU A 133
PHE A 146
 None
 0.93A 5gs4A-3mlgA:
undetectable		 5gs4A-3mlgA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Streptomyces
avermitilis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 LEU A 183
LEU A 258
LEU A   3
LEU A 254
 None
 0.97A 5gs4A-3n05A:
undetectable		 5gs4A-3n05A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6x GLUTAMINE SYNTHETASE

(Bacteroides
fragilis) 		PF00120
(Gln-synt_C)
PF12437
(GSIII_N) 		4 LEU A 123
LEU A 122
PHE A 105
LEU A 163
 None
 1.00A 5gs4A-3o6xA:
undetectable		 5gs4A-3o6xA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		4 LEU A 581
LEU A 539
PHE A 533
LEU A 499
 None
 0.92A 5gs4A-3opbA:
undetectable		 5gs4A-3opbA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qat MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Bartonella
henselae) 		PF00698
(Acyl_transf_1) 		4 LEU A 101
LEU A 116
PHE A 107
LEU A 218
 None
 1.01A 5gs4A-3qatA:
undetectable		 5gs4A-3qatA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfw RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large) 		4 LEU A 275
LEU A 267
PHE A 276
LEU A  84
 None
 0.99A 5gs4A-3qfwA:
undetectable		 5gs4A-3qfwA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sip CASPASE

(Drosophila
melanogaster) 		PF00656
(Peptidase_C14) 		4 LEU A  90
LEU B 249
LEU B 253
LEU B 215
 None
 0.92A 5gs4A-3sipA:
undetectable		 5gs4A-3sipA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		4 LEU A 235
LEU A 200
LEU A 486
PHE A 231
 None
None
None
NDP  A 801 (-4.4A)
 0.65A 5gs4A-3slkA:
undetectable		 5gs4A-3slkA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3viu PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 2

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 564
LEU A 687
LEU A 695
HIS A 619
 None
 1.02A 5gs4A-3viuA:
undetectable		 5gs4A-3viuA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LEU A4285
LEU A4410
LEU A4408
LEU A4355
 None
 0.71A 5gs4A-3vkgA:
undetectable		 5gs4A-3vkgA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		4 LEU A 417
LEU A 434
LEU A 431
LEU A 321
 None
 0.66A 5gs4A-3zgbA:
undetectable		 5gs4A-3zgbA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 LEU A 115
LEU A  67
PHE A 111
LEU A  80
 None
 0.86A 5gs4A-3zo9A:
undetectable		 5gs4A-3zo9A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b28 METALLOPEPTIDASE,
FAMILY M24, PUTATIVE

(Roseobacter
denitrificans) 		PF00557
(Peptidase_M24) 		4 LEU A  76
LEU A 183
PHE A  78
LEU A 139
 None
 0.95A 5gs4A-4b28A:
undetectable		 5gs4A-4b28A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edn BETA-PARVIN

(Homo sapiens) 		PF00307
(CH) 		4 LEU A 353
LEU A 295
PHE A 282
LEU A 268
 None
 0.90A 5gs4A-4ednA:
undetectable		 5gs4A-4ednA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd2 CHAPERONE PROTEIN
CLPB

(Thermus
thermophilus) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 LEU A 745
LEU A 684
LEU A 681
LEU A 706
 None
 0.95A 5gs4A-4fd2A:
undetectable		 5gs4A-4fd2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6z GLUTAMATE-TRNA
LIGASE

(Burkholderia
thailandensis) 		PF00749
(tRNA-synt_1c) 		4 LEU A 270
LEU A  26
PHE A   9
HIS A  18
 None
 0.99A 5gs4A-4g6zA:
undetectable		 5gs4A-4g6zA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 LEU A 341
LEU A 323
PHE A 551
LEU A 395
 None
 0.89A 5gs4A-4hozA:
undetectable		 5gs4A-4hozA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6n UBIQUITIN
CARBOXYL-HYDROLASE

(Trichinella
spiralis) 		PF01088
(Peptidase_C12) 		4 LEU A  90
LEU A  93
LEU A 108
HIS A  21
 None
 0.95A 5gs4A-4i6nA:
undetectable		 5gs4A-4i6nA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9f GLYCEROL 3-PHOSPHATE
PHOSPHATASE

(Mycobacterium
tuberculosis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 LEU A 254
LEU A 264
LEU A 205
HIS A 258
 None
 0.86A 5gs4A-4i9fA:
undetectable		 5gs4A-4i9fA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ig7 UBIQUITIN C-TERMINAL
HYDROLASE 37

(Trichinella
spiralis) 		PF01088
(Peptidase_C12) 		4 LEU A  90
LEU A  93
LEU A 108
HIS A  21
 None
 0.97A 5gs4A-4ig7A:
undetectable		 5gs4A-4ig7A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isc METHYLTRANSFERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF05401
(NodS) 		4 LEU A 123
LEU A 126
LEU A 167
HIS A 160
 None
 0.75A 5gs4A-4iscA:
undetectable		 5gs4A-4iscA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6c CYTOCHROME P450
MONOOXYGENASE

(Nocardia
farcinica) 		PF00067
(p450) 		4 LEU A 153
LEU A 145
LEU A 254
LEU A 371
 None
 1.02A 5gs4A-4j6cA:
2.6		 5gs4A-4j6cA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		4 LEU A 494
LEU A 509
PHE A 744
HIS A 526
 None
 0.78A 5gs4A-4nh0A:
undetectable		 5gs4A-4nh0A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7e RESPONSE REGULATOR
OF A TWO COMPONENT
REGULATORY SYSTEM

(Leptospira
biflexa) 		PF00072
(Response_reg) 		4 LEU A  54
LEU A  64
PHE A  79
LEU A  95
 None
 0.99A 5gs4A-4q7eA:
undetectable		 5gs4A-4q7eA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzz PEPTIDASE M24

(Ruegeria
lacuscaerulensis) 		PF00557
(Peptidase_M24) 		4 LEU A  76
LEU A 183
PHE A  78
LEU A 139
 None
 0.92A 5gs4A-4rzzA:
undetectable		 5gs4A-4rzzA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wva UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		PF01204
(Trehalase) 		4 LEU A 135
LEU A 142
PHE A  59
LEU A  33
 None
 0.82A 5gs4A-4wvaA:
undetectable		 5gs4A-4wvaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6

(Saccharomyces
cerevisiae) 		PF09295
(ChAPs) 		4 LEU B 531
LEU B 586
LEU B 589
LEU B 544
 None
 1.00A 5gs4A-4yg8B:
undetectable		 5gs4A-4yg8B:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zti POLYMERASE COFACTOR
VP35,NUCLEOPROTEIN

(Zaire
ebolavirus) 		PF02097
(Filo_VP35)
PF05505
(Ebola_NP) 		4 LEU A  79
PHE A 106
LEU A 209
HIS A 216
 None
 0.98A 5gs4A-4ztiA:
undetectable		 5gs4A-4ztiA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 LEU R 205
LEU R 232
LEU R 201
HIS R 444
 None
 1.00A 5gs4A-5a31R:
undetectable		 5gs4A-5a31R:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4p REPEBODY

(synthetic
construct) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 LEU A 161
LEU A 113
PHE A 152
LEU A 123
 None
 0.97A 5gs4A-5b4pA:
undetectable		 5gs4A-5b4pA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cnx AMINOPEPTIDASE YPDF

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 LEU A  20
LEU A  11
LEU A  16
LEU A  90
 None
 0.93A 5gs4A-5cnxA:
undetectable		 5gs4A-5cnxA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejs MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum) 		PF00373
(FERM_M)
PF00784
(MyTH4)
PF09380
(FERM_C) 		4 LEU A2262
LEU A2204
LEU A2201
LEU A2247
 None
 0.92A 5gs4A-5ejsA:
undetectable		 5gs4A-5ejsA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es6 LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00551
(Formyl_trans_N) 		4 LEU A 407
LEU A 412
PHE A 205
LEU A 271
 None
 1.01A 5gs4A-5es6A:
undetectable		 5gs4A-5es6A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00551
(Formyl_trans_N)
PF13193
(AMP-binding_C) 		4 LEU A 407
LEU A 412
PHE A 205
LEU A 271
 None
 1.02A 5gs4A-5es9A:
undetectable		 5gs4A-5es9A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5et1 ESPIN

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 LEU A   3
LEU A  18
LEU A  21
HIS A  42
 None
 0.96A 5gs4A-5et1A:
undetectable		 5gs4A-5et1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5et1 ESPIN

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 LEU A   7
LEU A  18
LEU A  21
LEU A  61
 None
 0.95A 5gs4A-5et1A:
undetectable		 5gs4A-5et1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdn PHOSPHOENOLPYRUVATE
CARBOXYLASE 3

(Arabidopsis
thaliana) 		PF00311
(PEPcase) 		4 LEU A 419
LEU A 436
LEU A 433
LEU A 322
 None
 0.72A 5gs4A-5fdnA:
3.1		 5gs4A-5fdnA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE

(Escherichia
coli) 		PF01814
(Hemerythrin)
PF04405
(ScdA_N) 		4 LEU A 167
LEU A 166
LEU A  91
HIS A 204
 None
None
None
ZN  A1222 ( 3.3A)
 0.98A 5gs4A-5fnpA:
2.8		 5gs4A-5fnpA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3

(Rattus
norvegicus) 		PF12796
(Ank_2)
PF16511
(FERM_f0) 		4 LEU A  55
LEU A  43
LEU A  40
LEU A  24
 None
 0.97A 5gs4A-5g4xA:
undetectable		 5gs4A-5g4xA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 LEU A 726
LEU A 730
LEU A 765
HIS A 743
 None
 0.90A 5gs4A-5ja1A:
undetectable		 5gs4A-5ja1A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		no annotation 4 LEU C 407
LEU C 412
PHE C 205
LEU C 271
 None
 0.98A 5gs4A-5jnfC:
undetectable		 5gs4A-5jnfC:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqc VP3

(Black queen
cell virus) 		no annotation 4 LEU C 170
LEU C 219
PHE C 134
LEU C  80
 None
 0.79A 5gs4A-5mqcC:
undetectable		 5gs4A-5mqcC:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzo UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN

(Chaetomium
thermophilum) 		PF06427
(UDP-g_GGTase) 		4 LEU A 811
LEU A 717
PHE A 828
LEU A 703
 None
 0.95A 5gs4A-5mzoA:
undetectable		 5gs4A-5mzoA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Homo sapiens) 		PF00443
(UCH) 		4 LEU A  86
LEU A 121
PHE A  92
LEU A 173
 None
 1.01A 5gs4A-5ohkA:
undetectable		 5gs4A-5ohkA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 LEU T 744
LEU T 741
PHE T 736
LEU T 706
 None
 0.80A 5gs4A-5ojsT:
undetectable		 5gs4A-5ojsT:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swk E3 UBIQUITIN-PROTEIN
LIGASE MDM2

(Homo sapiens) 		no annotation 4 LEU A 107
LEU A  38
LEU A  35
LEU A  85
 None
 1.00A 5gs4A-5swkA:
undetectable		 5gs4A-5swkA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 298
LEU A 339
PHE A 356
LEU A 380
HIS A 475
 EST  A 601 (-4.1A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.9A)
None
EST  A 601 (-4.4A)
 0.29A 5gs4A-5toaA:
30.8		 5gs4A-5toaA:
59.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis) 		no annotation 4 LEU A 133
LEU A 157
PHE A  84
LEU A  64
 None
 0.94A 5gs4A-5ufmA:
undetectable		 5gs4A-5ufmA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x18 CASEIN KINASE I
HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LEU A 261
LEU A 314
PHE A 265
LEU A 335
 None
 1.00A 5gs4A-5x18A:
undetectable		 5gs4A-5x18A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU C1600
LEU C1627
LEU C1624
PHE C1605
 None
 0.76A 5gs4A-5x6oC:
undetectable		 5gs4A-5x6oC:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z02 E3 UBIQUITIN-PROTEIN
LIGASE MDM2

(Homo sapiens) 		no annotation 4 LEU A  86
LEU A  17
LEU A  14
LEU A  64
 None
 0.96A 5gs4A-5z02A:
undetectable		 5gs4A-5z02A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 4 LEU A 258
LEU A 547
LEU A 550
LEU A 699
 None
 1.01A 5gs4A-6azpA:
undetectable		 5gs4A-6azpA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bc1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 28

(Homo sapiens) 		no annotation 4 LEU C1087
LEU C1080
LEU C1058
LEU C1117
 None
 0.96A 5gs4A-6bc1C:
undetectable		 5gs4A-6bc1C:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk5 UBIQUITIN LIGASE CBL

(Salpingoeca
rosetta) 		no annotation 4 LEU A 115
LEU A  51
LEU A  54
HIS A 108
 None
 0.91A 5gs4A-6bk5A:
undetectable		 5gs4A-6bk5A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccb GLYCOPROTEIN 120

(Human
immunodeficiency
virus 1) 		no annotation 4 LEU C 342
LEU C 452
PHE C 361
LEU C 349
 None
 0.92A 5gs4A-6ccbC:
undetectable		 5gs4A-6ccbC:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d04 RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 4 LEU E 443
LEU E 440
PHE E 435
LEU E 192
 None
 0.92A 5gs4A-6d04E:
1.7		 5gs4A-6d04E:
16.38