SIMILAR PATTERNS OF AMINO ACIDS FOR 5GQB_A_GCSA605_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ak0 P1 NUCLEASE

(Penicillium
citrinum)
PF02265
(S1-P1_nuclease)
3 TRP A 208
ILE A  87
SER A  86
None
0.97A 5gqbA-1ak0A:
undetectable
5gqbA-1ak0A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coo RNA POLYMERASE ALPHA
SUBUNIT


(Escherichia
coli)
PF03118
(RNA_pol_A_CTD)
3 TRP A 321
ILE A 326
SER A 325
None
1.00A 5gqbA-1cooA:
undetectable
5gqbA-1cooA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE

(Escherichia
coli)
PF00115
(COX1)
3 TRP A 331
ILE A 245
SER A 242
None
1.00A 5gqbA-1fftA:
undetectable
5gqbA-1fftA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkp HYDANTOINASE

(Thermus sp.)
PF01979
(Amidohydro_1)
3 TRP A 301
ILE A 309
SER A 263
None
0.91A 5gqbA-1gkpA:
6.9
5gqbA-1gkpA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE


(Paenarthrobacter
aurescens)
PF01979
(Amidohydro_1)
3 TRP A 298
ILE A 306
SER A 263
None
0.88A 5gqbA-1gkrA:
5.5
5gqbA-1gkrA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyd ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE A


(Cellvibrio
japonicus)
PF04616
(Glyco_hydro_43)
3 TRP B 177
ILE B 157
SER B 112
None
1.03A 5gqbA-1gydB:
undetectable
5gqbA-1gydB:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE


(Escherichia
coli)
PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N)
3 TRP A 418
ILE A 407
SER A 410
None
0.87A 5gqbA-1gytA:
undetectable
5gqbA-1gytA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE


(Alicyclobacillus
acidocaldarius)
PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N)
3 TRP A 247
ILE A 152
SER A 178
None
1.02A 5gqbA-1h39A:
undetectable
5gqbA-1h39A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7z ADENOVIRUS FIBRE
PROTEIN


(Human
mastadenovirus
B)
PF00541
(Adeno_knob)
3 TRP A 290
ILE A 145
SER A 154
None
0.97A 5gqbA-1h7zA:
undetectable
5gqbA-1h7zA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j93 UROPORPHYRINOGEN
DECARBOXYLASE


(Nicotiana
tabacum)
PF01208
(URO-D)
3 TRP A  29
ILE A 249
SER A 271
None
1.02A 5gqbA-1j93A:
7.3
5gqbA-1j93A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ntx ALPHA-NEUROTOXIN

(Dendroaspis
polylepis)
PF00087
(Toxin_TOLIP)
3 TRP A  29
ILE A  37
SER A   8
None
0.97A 5gqbA-1ntxA:
undetectable
5gqbA-1ntxA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otw COENZYME PQQ
SYNTHESIS PROTEIN C


(Klebsiella
pneumoniae)
PF03070
(TENA_THI-4)
3 TRP A  46
ILE A 153
SER A 156
None
PQQ  A 500 (-3.6A)
None
0.87A 5gqbA-1otwA:
undetectable
5gqbA-1otwA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT


(Acidaminococcus
fermentans)
PF01039
(Carboxyl_trans)
3 TRP A 410
ILE A 444
SER A 442
None
0.96A 5gqbA-1pixA:
2.7
5gqbA-1pixA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT


(Thermotoga
maritima)
PF01039
(Carboxyl_trans)
3 TRP A  38
ILE A  77
SER A  92
None
0.90A 5gqbA-1vrgA:
3.1
5gqbA-1vrgA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris)
PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965)
3 TRP A 637
ILE A 399
SER A 397
None
0.95A 5gqbA-1w7cA:
undetectable
5gqbA-1w7cA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcg THIOGLUCOSIDASE

(Brevicoryne
brassicae)
PF00232
(Glyco_hydro_1)
3 TRP A 123
ILE A 169
SER A 226
None
0.87A 5gqbA-1wcgA:
5.7
5gqbA-1wcgA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl7 ARABINANASE-TS

(Geobacillus
thermodenitrificans)
PF04616
(Glyco_hydro_43)
3 TRP A 166
ILE A 146
SER A 102
None
0.99A 5gqbA-1wl7A:
undetectable
5gqbA-1wl7A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl7 ARABINANASE-TS

(Geobacillus
thermodenitrificans)
PF04616
(Glyco_hydro_43)
3 TRP A 166
ILE A 146
SER A 109
None
0.96A 5gqbA-1wl7A:
undetectable
5gqbA-1wl7A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhc NADH OXIDASE
/NITRITE REDUCTASE


(Pyrococcus
furiosus)
PF07992
(Pyr_redox_2)
3 TRP A  61
ILE A  67
SER A  20
None
0.86A 5gqbA-1xhcA:
undetectable
5gqbA-1xhcA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli)
PF00480
(ROK)
3 TRP A 199
ILE A 340
SER A 345
None
1.01A 5gqbA-1z6rA:
undetectable
5gqbA-1z6rA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acy ACYLPHOSPHATASE

(Bos taurus)
PF00708
(Acylphosphatase)
3 TRP A  64
ILE A  75
SER A  73
None
0.81A 5gqbA-2acyA:
undetectable
5gqbA-2acyA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvl ACYL-COA
DEHYDROGENASE


(Thermus
thermophilus)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
3 TRP A  37
ILE A  84
SER A 157
None
1.00A 5gqbA-2dvlA:
undetectable
5gqbA-2dvlA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2b AQUAPORIN AQPM

(Methanothermobacter
marburgensis)
PF00230
(MIP)
3 TRP A 144
ILE A 224
SER A 223
None
0.99A 5gqbA-2f2bA:
undetectable
5gqbA-2f2bA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8t ARGONAUTE PROTEIN

(Aquifex
aeolicus)
PF02171
(Piwi)
3 TRP A  40
ILE A 190
SER A 222
None
1.01A 5gqbA-2f8tA:
undetectable
5gqbA-2f8tA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2foi ENOYL-ACYL CARRIER
REDUCTASE


(Plasmodium
falciparum)
PF13561
(adh_short_C2)
3 TRP A 113
ILE A 153
SER A 120
None
0.92A 5gqbA-2foiA:
undetectable
5gqbA-2foiA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fq4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY


(Bacillus cereus)
PF00440
(TetR_N)
PF16859
(TetR_C_11)
3 TRP A  53
ILE A  38
SER A  21
None
0.96A 5gqbA-2fq4A:
undetectable
5gqbA-2fq4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsz PROBABLE THIOL
PEROXIDASE


(Bacillus
subtilis)
PF08534
(Redoxin)
3 TRP A  93
ILE A  52
SER A  83
None
0.92A 5gqbA-2jszA:
undetectable
5gqbA-2jszA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2r GLUCOKINASE 1,
PUTATIVE


(Trypanosoma
cruzi)
PF02685
(Glucokinase)
3 TRP A 156
ILE A 302
SER A 294
None
1.02A 5gqbA-2q2rA:
undetectable
5gqbA-2q2rA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsp RSV PROTEASE

(Rous sarcoma
virus)
PF00077
(RVP)
3 TRP A  50
ILE A  32
SER A 107
None
0.61A 5gqbA-2rspA:
undetectable
5gqbA-2rspA:
12.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wk2 CHITINASE A

(Serratia
marcescens)
PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N)
3 TRP A 167
ILE A 207
SER A 210
SN5  A1563 ( 4.0A)
SN5  A1563 ( 4.0A)
SN5  A1563 (-3.6A)
0.68A 5gqbA-2wk2A:
65.8
5gqbA-2wk2A:
72.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wk2 CHITINASE A

(Serratia
marcescens)
PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N)
3 TRP A 314
ILE A 312
SER A 361
None
0.92A 5gqbA-2wk2A:
65.8
5gqbA-2wk2A:
72.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxz LYSINE-SPECIFIC
DEMETHYLASE 6B


(Homo sapiens)
PF02373
(JmjC)
3 TRP A1474
ILE A1323
SER A1382
None
1.02A 5gqbA-2xxzA:
undetectable
5gqbA-2xxzA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5q PUTATIVE SULFATASE
YIDJ


(Bacteroides
thetaiotaomicron)
PF00884
(Sulfatase)
PF16347
(DUF4976)
3 TRP A 375
ILE A 224
SER A 227
None
0.81A 5gqbA-3b5qA:
undetectable
5gqbA-3b5qA:
21.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b9e CHITINASE A

(Vibrio harveyi)
PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N)
3 TRP A 314
ILE A 312
SER A 362
None
0.95A 5gqbA-3b9eA:
38.1
5gqbA-3b9eA:
50.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bex TYPE III
PANTOTHENATE KINASE


(Thermotoga
maritima)
PF03309
(Pan_kinase)
3 TRP A  84
ILE A  57
SER A  74
None
0.91A 5gqbA-3bexA:
undetectable
5gqbA-3bexA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3v ARACHIN ARAH3
ISOFORM


(Arachis
hypogaea)
PF00190
(Cupin_1)
3 TRP A 389
ILE A  21
SER A 473
None
0.71A 5gqbA-3c3vA:
undetectable
5gqbA-3c3vA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e74 ALLANTOINASE

(Escherichia
coli)
PF01979
(Amidohydro_1)
3 TRP A 301
ILE A 309
SER A 266
None
0.99A 5gqbA-3e74A:
4.4
5gqbA-3e74A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE


(Plasmodium
berghei)
PF13561
(adh_short_C2)
3 TRP A  96
ILE A 136
SER A 103
None
1.01A 5gqbA-3f4bA:
2.3
5gqbA-3f4bA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0i EPOXIDE HYDROLASE

(Aspergillus
niger)
PF06441
(EHN)
3 TRP A 302
ILE A 271
SER A  38
None
1.04A 5gqbA-3g0iA:
undetectable
5gqbA-3g0iA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE


(Arthrobacter
globiformis)
PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M)
3 TRP A 657
ILE A 639
SER A 620
None
0.76A 5gqbA-3gsiA:
undetectable
5gqbA-3gsiA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2i ESTERASE

(Xanthomonas
oryzae)
PF03583
(LIP)
3 TRP A 261
ILE A 232
SER A 236
None
0.99A 5gqbA-3h2iA:
undetectable
5gqbA-3h2iA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9c METHIONYL-TRNA
SYNTHETASE


(Escherichia
coli)
PF09334
(tRNA-synt_1g)
3 TRP A 281
ILE A 109
SER A 312
None
0.96A 5gqbA-3h9cA:
undetectable
5gqbA-3h9cA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
3 TRP A 393
ILE A  65
SER A  64
None
1.00A 5gqbA-3ihvA:
undetectable
5gqbA-3ihvA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus)
no annotation 3 TRP A 821
ILE A 855
SER A 802
None
0.88A 5gqbA-3j3iA:
undetectable
5gqbA-3j3iA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kpx APOPHOTOPROTEIN
CLYTIN-3


(Clytia gregaria)
PF13202
(EF-hand_5)
3 TRP A 117
ILE A 147
SER A 145
CZH  A 201 (-3.8A)
CZH  A 201 (-4.1A)
CZH  A 201 ( 4.5A)
1.03A 5gqbA-3kpxA:
undetectable
5gqbA-3kpxA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdu N-FORMIMINO-L-GLUTAM
ATE IMINOHYDROLASE


(Pseudomonas
aeruginosa)
PF01979
(Amidohydro_1)
3 TRP A 427
ILE A  23
SER A   2
None
1.02A 5gqbA-3mduA:
2.8
5gqbA-3mduA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6z PUTATIVE
IMMUNOGLOBULIN A1
PROTEASE


(Bacteroides
ovatus)
no annotation 3 TRP A 367
ILE A 376
SER A 380
None
0.99A 5gqbA-3n6zA:
undetectable
5gqbA-3n6zA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5e ATLASTIN-1

(Homo sapiens)
PF02263
(GBP)
3 TRP A 303
ILE A 173
SER A 211
None
1.03A 5gqbA-3q5eA:
undetectable
5gqbA-3q5eA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT


(Cryptococcus
neoformans)
PF01239
(PPTA)
3 TRP A 148
ILE A 134
SER A 137
None
0.94A 5gqbA-3sfyA:
undetectable
5gqbA-3sfyA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsc PUTATIVE
OXIDOREDUCTASE


(Mycobacterium
avium)
PF13561
(adh_short_C2)
3 TRP A 250
ILE A 153
SER A 151
None
0.91A 5gqbA-3tscA:
3.3
5gqbA-3tscA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqi ATG5

(Kluyveromyces
marxianus)
PF04106
(APG5)
3 TRP A 144
ILE A 173
SER A 172
None
0.98A 5gqbA-3vqiA:
undetectable
5gqbA-3vqiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2


(Saccharomyces
cerevisiae)
PF04054
(Not1)
PF04153
(NOT2_3_5)
3 TRP B  60
ILE A1812
SER A1758
None
1.03A 5gqbA-4by6B:
undetectable
5gqbA-4by6B:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus)
PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M)
3 TRP A 214
ILE A 217
SER A 210
None
0.97A 5gqbA-4ccdA:
10.7
5gqbA-4ccdA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3


(Homo sapiens)
PF01825
(GPS)
PF02793
(HRM)
PF16489
(GAIN)
3 TRP A 834
ILE A 672
SER A 671
None
0.89A 5gqbA-4dloA:
undetectable
5gqbA-4dloA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fas HYDROXYLAMINE
OXIDOREDUCTASE


(Nitrosomonas
europaea)
PF13447
(Multi-haem_cyto)
3 TRP A 217
ILE A  52
SER A  55
None
0.94A 5gqbA-4fasA:
undetectable
5gqbA-4fasA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8i HYPOTHETICAL PROTEIN

(Bacteroides
uniformis)
PF16227
(DUF4886)
3 TRP A 160
ILE A 185
SER A 127
None
0.66A 5gqbA-4i8iA:
2.7
5gqbA-4i8iA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE


(Saccharomyces
cerevisiae)
PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N)
3 TRP A 628
ILE A 667
SER A 671
None
0.83A 5gqbA-4j5tA:
undetectable
5gqbA-4j5tA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1


(Saccharomyces
cerevisiae)
PF00155
(Aminotran_1_2)
3 TRP A 145
ILE A 215
SER A 165
None
PLP  A 601 (-3.9A)
None
1.02A 5gqbA-4je5A:
2.5
5gqbA-4je5A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmn PROBABLE
L,D-TRANSPEPTIDASE
LDTA


(Mycobacterium
tuberculosis)
PF03734
(YkuD)
3 TRP A  88
ILE A  74
SER A  73
None
1.00A 5gqbA-4jmnA:
2.7
5gqbA-4jmnA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A


(Mus musculus)
PF13516
(LRR_6)
3 TRP A 508
ILE A 515
SER A 514
None
0.88A 5gqbA-4k17A:
2.0
5gqbA-4k17A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4liy FIBER PROTEIN

(Human
mastadenovirus
B)
PF00541
(Adeno_knob)
3 TRP A 290
ILE A 145
SER A 154
None
0.96A 5gqbA-4liyA:
undetectable
5gqbA-4liyA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mcj UNCHARACTERIZED
PROTEIN


(Parabacteroides
distasonis)
PF15891
(Nuc_deoxyri_tr2)
3 TRP A  60
ILE A 115
SER A 121
None
0.98A 5gqbA-4mcjA:
2.1
5gqbA-4mcjA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9d RIK1-ASSOCIATED
FACTOR 1


(Schizosaccharomyces
pombe)
no annotation 3 TRP B 573
ILE B 549
SER B 506
None
0.78A 5gqbA-4o9dB:
undetectable
5gqbA-4o9dB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovy HALOACID
DEHALOGENASE DOMAIN
PROTEIN HYDROLASE


(Planctopirus
limnophila)
PF12710
(HAD)
3 TRP A  71
ILE A 182
SER A 184
None
None
EDO  A 407 ( 4.3A)
1.01A 5gqbA-4ovyA:
undetectable
5gqbA-4ovyA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE


(Escherichia
coli)
PF14883
(GHL13)
3 TRP A 387
ILE A 340
SER A 393
None
0.87A 5gqbA-4p7lA:
17.0
5gqbA-4p7lA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT


(Cupriavidus
necator)
PF03480
(DctP)
3 TRP A 101
ILE A  91
SER A  36
None
0.92A 5gqbA-4p8bA:
undetectable
5gqbA-4p8bA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qex ERYTHROCYTE-BINDING
ANTIGEN-175


(Plasmodium
falciparum)
PF05424
(Duffy_binding)
3 TRP A 463
ILE A 377
SER A 380
None
0.84A 5gqbA-4qexA:
undetectable
5gqbA-4qexA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE


(Leishmania
major)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
3 TRP A 372
ILE A 407
SER A  95
None
1.03A 5gqbA-4qg5A:
undetectable
5gqbA-4qg5A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0s PROTEIN TYROSINE
PHOSPHATASE TPBA


(Pseudomonas
aeruginosa)
PF03162
(Y_phosphatase2)
3 TRP A  89
ILE A  47
SER A  59
None
0.77A 5gqbA-4r0sA:
undetectable
5gqbA-4r0sA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uv6 APICAL MEROZOITE
ANTIGEN 1


(Plasmodium
knowlesi)
PF02430
(AMA-1)
3 TRP A 344
ILE A  72
SER A 290
None
1.04A 5gqbA-4uv6A:
undetectable
5gqbA-4uv6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8b EXO-XYLOGLUCANASE

(uncultured
bacterium)
PF00150
(Cellulase)
3 TRP A 171
ILE A 200
SER A 197
BGC  A 603 ( 4.3A)
None
None
1.04A 5gqbA-4w8bA:
11.6
5gqbA-4w8bA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN SEH1

(Saccharomyces
cerevisiae)
PF00400
(WD40)
3 TRP C  51
ILE C  58
SER C  74
None
0.94A 5gqbA-4xmmC:
undetectable
5gqbA-4xmmC:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz6 GLYCINE
BETAINE/PROLINE ABC
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN


(Ruegeria
pomeroyi)
PF04069
(OpuAC)
3 TRP A  55
ILE A  52
SER A  62
TMO  A 401 ( 3.8A)
None
None
0.98A 5gqbA-4xz6A:
undetectable
5gqbA-4xz6A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq9 UNCHARACTERIZED
PROTEIN


(Legionella
pneumophila)
PF12252
(SidE)
3 TRP A 481
ILE A 492
SER A 494
None
0.99A 5gqbA-5bq9A:
undetectable
5gqbA-5bq9A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cow PUTATIVE
UNCHARACTERIZED
PROTEIN


(Caenorhabditis
remanei)
no annotation 3 TRP A 343
ILE A 317
SER A 438
None
0.85A 5gqbA-5cowA:
undetectable
5gqbA-5cowA:
18.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus)
PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N)
3 TRP A 157
ILE A 197
SER A 200
None
0.68A 5gqbA-5df0A:
62.6
5gqbA-5df0A:
61.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3b MACRODOMAIN PROTEIN

(Streptomyces
coelicolor)
no annotation 3 TRP A 134
ILE A   4
SER A 142
None
1.01A 5gqbA-5e3bA:
undetectable
5gqbA-5e3bA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ekd TRYPTOPHAN--TRNA
LIGASE,
MITOCHONDRIAL


(Homo sapiens)
PF00579
(tRNA-synt_1b)
3 TRP A  59
ILE A 104
SER A 109
None
1.01A 5gqbA-5ekdA:
undetectable
5gqbA-5ekdA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR


(Acinetobacter
baumannii)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
3 TRP A 314
ILE A 364
SER A 372
None
1.00A 5gqbA-5fp1A:
undetectable
5gqbA-5fp1A:
21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gpr CHITINASE

(Ostrinia
furnacalis)
PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N)
3 TRP A 160
ILE A 200
SER A 203
TRP  A 160 ( 0.5A)
ILE  A 200 ( 0.7A)
SER  A 203 ( 0.0A)
0.27A 5gqbA-5gprA:
67.9
5gqbA-5gprA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF11864
(DUF3384)
3 TRP A 129
ILE A 136
SER A 148
TRP  A 129 ( 0.5A)
ILE  A 136 ( 0.6A)
SER  A 148 ( 0.0A)
0.91A 5gqbA-5hiuA:
undetectable
5gqbA-5hiuA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE


(Human
picobirnavirus)
no annotation 3 TRP B  51
ILE B  58
SER B  57
None
1.02A 5gqbA-5i61B:
undetectable
5gqbA-5i61B:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ioj HALOALKYLPHOSPHORUS
HYDROLASE


(Sphingobium sp.
TCM1)
no annotation 3 TRP A 531
ILE A 158
SER A 220
None
0.72A 5gqbA-5iojA:
undetectable
5gqbA-5iojA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvv BETA-1,3-GLUCOSYLTRA
NSFERASE


(Paecilomyces
sp.
'thermophila')
no annotation 3 TRP B 199
ILE B 210
SER B 209
None
0.96A 5gqbA-5jvvB:
undetectable
5gqbA-5jvvB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1


(Rattus
norvegicus)
PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF13426
(PAS_9)
3 TRP A 370
ILE A 456
SER A 433
None
0.94A 5gqbA-5k7lA:
undetectable
5gqbA-5k7lA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA


(Mus musculus)
PF01532
(Glyco_hydro_47)
3 TRP A 326
ILE A 324
SER A 322
None
0.99A 5gqbA-5kkbA:
undetectable
5gqbA-5kkbA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq6 VIRULENCE PROTEIN
VSDE


(Salmonella
enterica)
PF05563
(SpvD)
3 TRP A 184
ILE A 157
SER A 160
None
0.92A 5gqbA-5lq6A:
undetectable
5gqbA-5lq6A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ov3 RETINOBLASTOMA-BINDI
NG PROTEIN 5


(Mus musculus)
no annotation 3 TRP A  93
ILE A  89
SER A  85
None
1.00A 5gqbA-5ov3A:
undetectable
5gqbA-5ov3A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2x UNCHARACTERIZED
PROTEIN LPG1670


(Legionella
pneumophila)
no annotation 3 TRP A 237
ILE A 217
SER A 213
None
0.86A 5gqbA-5t2xA:
undetectable
5gqbA-5t2xA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tii 3-OXOACYL-ACP
REDUCTASE


(uncultured
bacterium)
PF13561
(adh_short_C2)
3 TRP A 231
ILE A 140
SER A 138
None
0.87A 5gqbA-5tiiA:
3.5
5gqbA-5tiiA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjc KINETOCHORE PROTEIN
MIS16


(Schizosaccharomyces
pombe)
no annotation 3 TRP A 417
ILE A 340
SER A 334
None
0.99A 5gqbA-5wjcA:
undetectable
5gqbA-5wjcA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1


(Homo sapiens)
PF00400
(WD40)
PF00931
(NB-ARC)
3 TRP A1061
ILE A1027
SER A1021
None
0.87A 5gqbA-5wveA:
undetectable
5gqbA-5wveA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens)
no annotation 3 TRP A 167
ILE A 207
SER A 210
GOL  A 707 (-4.0A)
GOL  A 707 ( 4.5A)
GOL  A 707 (-3.2A)
0.59A 5gqbA-5zl9A:
64.5
5gqbA-5zl9A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens)
no annotation 3 TRP A 314
ILE A 312
SER A 361
None
0.90A 5gqbA-5zl9A:
64.5
5gqbA-5zl9A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9g ATLASTIN-1

(Homo sapiens)
no annotation 3 TRP B 303
ILE B 173
SER B 211
None
0.59A 5gqbA-6b9gB:
undetectable
5gqbA-6b9gB:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3


(Saccharomyces
cerevisiae)
no annotation 3 TRP A 598
ILE A 602
SER A 552
None
0.98A 5gqbA-6c26A:
undetectable
5gqbA-6c26A:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2j RNAP2

(Escherichia
virus N4)
no annotation 3 TRP B 183
ILE B 247
SER B 246
None
0.90A 5gqbA-6c2jB:
undetectable
5gqbA-6c2jB:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ces RAS-RELATED
GTP-BINDING PROTEIN
A


(Homo sapiens)
no annotation 3 TRP A 165
ILE A  26
SER A  22
GNP  A 500 (-4.6A)
None
GNP  A 500 (-4.4A)
0.92A 5gqbA-6cesA:
3.7
5gqbA-6cesA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyd PUTATIVE
FAD-DEPENDENT
OXYGENASE ENCM


(Streptomyces
maritimus)
no annotation 3 TRP A 275
ILE A 289
SER A 288
None
1.02A 5gqbA-6fydA:
undetectable
5gqbA-6fydA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE


(Paenibacillus
sp. YM1)
no annotation 3 TRP A 342
ILE A 776
SER A 774
None
0.85A 5gqbA-6gh2A:
undetectable
5gqbA-6gh2A:
8.07