SIMILAR PATTERNS OF AMINO ACIDS FOR 5GQB_A_GCSA605_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ak0 | P1 NUCLEASE (Penicilliumcitrinum) |
PF02265(S1-P1_nuclease) | 3 | TRP A 208ILE A 87SER A 86 | None | 0.97A | 5gqbA-1ak0A:undetectable | 5gqbA-1ak0A:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1coo | RNA POLYMERASE ALPHASUBUNIT (Escherichiacoli) |
PF03118(RNA_pol_A_CTD) | 3 | TRP A 321ILE A 326SER A 325 | None | 1.00A | 5gqbA-1cooA:undetectable | 5gqbA-1cooA:9.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fft | UBIQUINOL OXIDASE (Escherichiacoli) |
PF00115(COX1) | 3 | TRP A 331ILE A 245SER A 242 | None | 1.00A | 5gqbA-1fftA:undetectable | 5gqbA-1fftA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gkp | HYDANTOINASE (Thermus sp.) |
PF01979(Amidohydro_1) | 3 | TRP A 301ILE A 309SER A 263 | None | 0.91A | 5gqbA-1gkpA:6.9 | 5gqbA-1gkpA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gkr | NON-ATP DEPENDENTL-SELECTIVEHYDANTOINASE (Paenarthrobacteraurescens) |
PF01979(Amidohydro_1) | 3 | TRP A 298ILE A 306SER A 263 | None | 0.88A | 5gqbA-1gkrA:5.5 | 5gqbA-1gkrA:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gyd | ARABINANENDO-1,5-ALPHA-L-ARABINOSIDASE A (Cellvibriojaponicus) |
PF04616(Glyco_hydro_43) | 3 | TRP B 177ILE B 157SER B 112 | None | 1.03A | 5gqbA-1gydB:undetectable | 5gqbA-1gydB:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gyt | CYTOSOLAMINOPEPTIDASE (Escherichiacoli) |
PF00883(Peptidase_M17)PF02789(Peptidase_M17_N) | 3 | TRP A 418ILE A 407SER A 410 | None | 0.87A | 5gqbA-1gytA:undetectable | 5gqbA-1gytA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h39 | SQUALENE--HOPENECYCLASE (Alicyclobacillusacidocaldarius) |
PF13243(SQHop_cyclase_C)PF13249(SQHop_cyclase_N) | 3 | TRP A 247ILE A 152SER A 178 | None | 1.02A | 5gqbA-1h39A:undetectable | 5gqbA-1h39A:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h7z | ADENOVIRUS FIBREPROTEIN (HumanmastadenovirusB) |
PF00541(Adeno_knob) | 3 | TRP A 290ILE A 145SER A 154 | None | 0.97A | 5gqbA-1h7zA:undetectable | 5gqbA-1h7zA:16.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j93 | UROPORPHYRINOGENDECARBOXYLASE (Nicotianatabacum) |
PF01208(URO-D) | 3 | TRP A 29ILE A 249SER A 271 | None | 1.02A | 5gqbA-1j93A:7.3 | 5gqbA-1j93A:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ntx | ALPHA-NEUROTOXIN (Dendroaspispolylepis) |
PF00087(Toxin_TOLIP) | 3 | TRP A 29ILE A 37SER A 8 | None | 0.97A | 5gqbA-1ntxA:undetectable | 5gqbA-1ntxA:5.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1otw | COENZYME PQQSYNTHESIS PROTEIN C (Klebsiellapneumoniae) |
PF03070(TENA_THI-4) | 3 | TRP A 46ILE A 153SER A 156 | NonePQQ A 500 (-3.6A)None | 0.87A | 5gqbA-1otwA:undetectable | 5gqbA-1otwA:16.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pix | GLUTACONYL-COADECARBOXYLASE ASUBUNIT (Acidaminococcusfermentans) |
PF01039(Carboxyl_trans) | 3 | TRP A 410ILE A 444SER A 442 | None | 0.96A | 5gqbA-1pixA:2.7 | 5gqbA-1pixA:24.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vrg | PROPIONYL-COACARBOXYLASE, BETASUBUNIT (Thermotogamaritima) |
PF01039(Carboxyl_trans) | 3 | TRP A 38ILE A 77SER A 92 | None | 0.90A | 5gqbA-1vrgA:3.1 | 5gqbA-1vrgA:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w7c | LYSYL OXIDASE (Komagataellapastoris) |
PF01179(Cu_amine_oxid)PF02727(Cu_amine_oxidN2)PF09248(DUF1965) | 3 | TRP A 637ILE A 399SER A 397 | None | 0.95A | 5gqbA-1w7cA:undetectable | 5gqbA-1w7cA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wcg | THIOGLUCOSIDASE (Brevicorynebrassicae) |
PF00232(Glyco_hydro_1) | 3 | TRP A 123ILE A 169SER A 226 | None | 0.87A | 5gqbA-1wcgA:5.7 | 5gqbA-1wcgA:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wl7 | ARABINANASE-TS (Geobacillusthermodenitrificans) |
PF04616(Glyco_hydro_43) | 3 | TRP A 166ILE A 146SER A 102 | None | 0.99A | 5gqbA-1wl7A:undetectable | 5gqbA-1wl7A:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wl7 | ARABINANASE-TS (Geobacillusthermodenitrificans) |
PF04616(Glyco_hydro_43) | 3 | TRP A 166ILE A 146SER A 109 | None | 0.96A | 5gqbA-1wl7A:undetectable | 5gqbA-1wl7A:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xhc | NADH OXIDASE/NITRITE REDUCTASE (Pyrococcusfuriosus) |
PF07992(Pyr_redox_2) | 3 | TRP A 61ILE A 67SER A 20 | None | 0.86A | 5gqbA-1xhcA:undetectable | 5gqbA-1xhcA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z6r | MLC PROTEIN (Escherichiacoli) |
PF00480(ROK) | 3 | TRP A 199ILE A 340SER A 345 | None | 1.01A | 5gqbA-1z6rA:undetectable | 5gqbA-1z6rA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2acy | ACYLPHOSPHATASE (Bos taurus) |
PF00708(Acylphosphatase) | 3 | TRP A 64ILE A 75SER A 73 | None | 0.81A | 5gqbA-2acyA:undetectable | 5gqbA-2acyA:12.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dvl | ACYL-COADEHYDROGENASE (Thermusthermophilus) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 3 | TRP A 37ILE A 84SER A 157 | None | 1.00A | 5gqbA-2dvlA:undetectable | 5gqbA-2dvlA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f2b | AQUAPORIN AQPM (Methanothermobactermarburgensis) |
PF00230(MIP) | 3 | TRP A 144ILE A 224SER A 223 | None | 0.99A | 5gqbA-2f2bA:undetectable | 5gqbA-2f2bA:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f8t | ARGONAUTE PROTEIN (Aquifexaeolicus) |
PF02171(Piwi) | 3 | TRP A 40ILE A 190SER A 222 | None | 1.01A | 5gqbA-2f8tA:undetectable | 5gqbA-2f8tA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2foi | ENOYL-ACYL CARRIERREDUCTASE (Plasmodiumfalciparum) |
PF13561(adh_short_C2) | 3 | TRP A 113ILE A 153SER A 120 | None | 0.92A | 5gqbA-2foiA:undetectable | 5gqbA-2foiA:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fq4 | TRANSCRIPTIONALREGULATOR, TETRFAMILY (Bacillus cereus) |
PF00440(TetR_N)PF16859(TetR_C_11) | 3 | TRP A 53ILE A 38SER A 21 | None | 0.96A | 5gqbA-2fq4A:undetectable | 5gqbA-2fq4A:16.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jsz | PROBABLE THIOLPEROXIDASE (Bacillussubtilis) |
PF08534(Redoxin) | 3 | TRP A 93ILE A 52SER A 83 | None | 0.92A | 5gqbA-2jszA:undetectable | 5gqbA-2jszA:14.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q2r | GLUCOKINASE 1,PUTATIVE (Trypanosomacruzi) |
PF02685(Glucokinase) | 3 | TRP A 156ILE A 302SER A 294 | None | 1.02A | 5gqbA-2q2rA:undetectable | 5gqbA-2q2rA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rsp | RSV PROTEASE (Rous sarcomavirus) |
PF00077(RVP) | 3 | TRP A 50ILE A 32SER A 107 | None | 0.61A | 5gqbA-2rspA:undetectable | 5gqbA-2rspA:12.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wk2 | CHITINASE A (Serratiamarcescens) |
PF00704(Glyco_hydro_18)PF08329(ChitinaseA_N) | 3 | TRP A 167ILE A 207SER A 210 | SN5 A1563 ( 4.0A)SN5 A1563 ( 4.0A)SN5 A1563 (-3.6A) | 0.68A | 5gqbA-2wk2A:65.8 | 5gqbA-2wk2A:72.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wk2 | CHITINASE A (Serratiamarcescens) |
PF00704(Glyco_hydro_18)PF08329(ChitinaseA_N) | 3 | TRP A 314ILE A 312SER A 361 | None | 0.92A | 5gqbA-2wk2A:65.8 | 5gqbA-2wk2A:72.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xxz | LYSINE-SPECIFICDEMETHYLASE 6B (Homo sapiens) |
PF02373(JmjC) | 3 | TRP A1474ILE A1323SER A1382 | None | 1.02A | 5gqbA-2xxzA:undetectable | 5gqbA-2xxzA:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b5q | PUTATIVE SULFATASEYIDJ (Bacteroidesthetaiotaomicron) |
PF00884(Sulfatase)PF16347(DUF4976) | 3 | TRP A 375ILE A 224SER A 227 | None | 0.81A | 5gqbA-3b5qA:undetectable | 5gqbA-3b5qA:21.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b9e | CHITINASE A (Vibrio harveyi) |
PF00704(Glyco_hydro_18)PF08329(ChitinaseA_N) | 3 | TRP A 314ILE A 312SER A 362 | None | 0.95A | 5gqbA-3b9eA:38.1 | 5gqbA-3b9eA:50.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bex | TYPE IIIPANTOTHENATE KINASE (Thermotogamaritima) |
PF03309(Pan_kinase) | 3 | TRP A 84ILE A 57SER A 74 | None | 0.91A | 5gqbA-3bexA:undetectable | 5gqbA-3bexA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c3v | ARACHIN ARAH3ISOFORM (Arachishypogaea) |
PF00190(Cupin_1) | 3 | TRP A 389ILE A 21SER A 473 | None | 0.71A | 5gqbA-3c3vA:undetectable | 5gqbA-3c3vA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e74 | ALLANTOINASE (Escherichiacoli) |
PF01979(Amidohydro_1) | 3 | TRP A 301ILE A 309SER A 266 | None | 0.99A | 5gqbA-3e74A:4.4 | 5gqbA-3e74A:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f4b | ENOYL-ACYL CARRIERPROTEIN REDUCTASE (Plasmodiumberghei) |
PF13561(adh_short_C2) | 3 | TRP A 96ILE A 136SER A 103 | None | 1.01A | 5gqbA-3f4bA:2.3 | 5gqbA-3f4bA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g0i | EPOXIDE HYDROLASE (Aspergillusniger) |
PF06441(EHN) | 3 | TRP A 302ILE A 271SER A 38 | None | 1.04A | 5gqbA-3g0iA:undetectable | 5gqbA-3g0iA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gsi | N,N-DIMETHYLGLYCINEOXIDASE (Arthrobacterglobiformis) |
PF01266(DAO)PF01571(GCV_T)PF08669(GCV_T_C)PF16350(FAO_M) | 3 | TRP A 657ILE A 639SER A 620 | None | 0.76A | 5gqbA-3gsiA:undetectable | 5gqbA-3gsiA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h2i | ESTERASE (Xanthomonasoryzae) |
PF03583(LIP) | 3 | TRP A 261ILE A 232SER A 236 | None | 0.99A | 5gqbA-3h2iA:undetectable | 5gqbA-3h2iA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h9c | METHIONYL-TRNASYNTHETASE (Escherichiacoli) |
PF09334(tRNA-synt_1g) | 3 | TRP A 281ILE A 109SER A 312 | None | 0.96A | 5gqbA-3h9cA:undetectable | 5gqbA-3h9cA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ihv | SUSD HOMOLOG (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 3 | TRP A 393ILE A 65SER A 64 | None | 1.00A | 5gqbA-3ihvA:undetectable | 5gqbA-3ihvA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j3i | CAPSID PROTEIN (Penicilliumchrysogenumvirus) |
no annotation | 3 | TRP A 821ILE A 855SER A 802 | None | 0.88A | 5gqbA-3j3iA:undetectable | 5gqbA-3j3iA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kpx | APOPHOTOPROTEINCLYTIN-3 (Clytia gregaria) |
PF13202(EF-hand_5) | 3 | TRP A 117ILE A 147SER A 145 | CZH A 201 (-3.8A)CZH A 201 (-4.1A)CZH A 201 ( 4.5A) | 1.03A | 5gqbA-3kpxA:undetectable | 5gqbA-3kpxA:16.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdu | N-FORMIMINO-L-GLUTAMATE IMINOHYDROLASE (Pseudomonasaeruginosa) |
PF01979(Amidohydro_1) | 3 | TRP A 427ILE A 23SER A 2 | None | 1.02A | 5gqbA-3mduA:2.8 | 5gqbA-3mduA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n6z | PUTATIVEIMMUNOGLOBULIN A1PROTEASE (Bacteroidesovatus) |
no annotation | 3 | TRP A 367ILE A 376SER A 380 | None | 0.99A | 5gqbA-3n6zA:undetectable | 5gqbA-3n6zA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q5e | ATLASTIN-1 (Homo sapiens) |
PF02263(GBP) | 3 | TRP A 303ILE A 173SER A 211 | None | 1.03A | 5gqbA-3q5eA:undetectable | 5gqbA-3q5eA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sfy | CRYPTOCOCCUSNEOFORMANS PROTEINFARNESYLTRANSFERASEALPHA SUBUNIT (Cryptococcusneoformans) |
PF01239(PPTA) | 3 | TRP A 148ILE A 134SER A 137 | None | 0.94A | 5gqbA-3sfyA:undetectable | 5gqbA-3sfyA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsc | PUTATIVEOXIDOREDUCTASE (Mycobacteriumavium) |
PF13561(adh_short_C2) | 3 | TRP A 250ILE A 153SER A 151 | None | 0.91A | 5gqbA-3tscA:3.3 | 5gqbA-3tscA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vqi | ATG5 (Kluyveromycesmarxianus) |
PF04106(APG5) | 3 | TRP A 144ILE A 173SER A 172 | None | 0.98A | 5gqbA-3vqiA:undetectable | 5gqbA-3vqiA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4by6 | GENERAL NEGATIVEREGULATOR OFTRANSCRIPTIONSUBUNIT 1GENERAL NEGATIVEREGULATOR OFTRANSCRIPTIONSUBUNIT 2 (Saccharomycescerevisiae) |
PF04054(Not1)PF04153(NOT2_3_5) | 3 | TRP B 60ILE A1812SER A1758 | None | 1.03A | 5gqbA-4by6B:undetectable | 5gqbA-4by6B:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ccd | GALACTOCEREBROSIDASE (Mus musculus) |
PF02057(Glyco_hydro_59)PF17387(Glyco_hydro_59M) | 3 | TRP A 214ILE A 217SER A 210 | None | 0.97A | 5gqbA-4ccdA:10.7 | 5gqbA-4ccdA:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dlo | BRAIN-SPECIFICANGIOGENESISINHIBITOR 3 (Homo sapiens) |
PF01825(GPS)PF02793(HRM)PF16489(GAIN) | 3 | TRP A 834ILE A 672SER A 671 | None | 0.89A | 5gqbA-4dloA:undetectable | 5gqbA-4dloA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fas | HYDROXYLAMINEOXIDOREDUCTASE (Nitrosomonaseuropaea) |
PF13447(Multi-haem_cyto) | 3 | TRP A 217ILE A 52SER A 55 | None | 0.94A | 5gqbA-4fasA:undetectable | 5gqbA-4fasA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i8i | HYPOTHETICAL PROTEIN (Bacteroidesuniformis) |
PF16227(DUF4886) | 3 | TRP A 160ILE A 185SER A 127 | None | 0.66A | 5gqbA-4i8iA:2.7 | 5gqbA-4i8iA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j5t | MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE (Saccharomycescerevisiae) |
PF03200(Glyco_hydro_63)PF16923(Glyco_hydro_63N) | 3 | TRP A 628ILE A 667SER A 671 | None | 0.83A | 5gqbA-4j5tA:undetectable | 5gqbA-4j5tA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4je5 | AROMATIC/AMINOADIPATE AMINOTRANSFERASE 1 (Saccharomycescerevisiae) |
PF00155(Aminotran_1_2) | 3 | TRP A 145ILE A 215SER A 165 | NonePLP A 601 (-3.9A)None | 1.02A | 5gqbA-4je5A:2.5 | 5gqbA-4je5A:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jmn | PROBABLEL,D-TRANSPEPTIDASELDTA (Mycobacteriumtuberculosis) |
PF03734(YkuD) | 3 | TRP A 88ILE A 74SER A 73 | None | 1.00A | 5gqbA-4jmnA:2.7 | 5gqbA-4jmnA:17.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k17 | LEUCINE-RICHREPEAT-CONTAININGPROTEIN 16A (Mus musculus) |
PF13516(LRR_6) | 3 | TRP A 508ILE A 515SER A 514 | None | 0.88A | 5gqbA-4k17A:2.0 | 5gqbA-4k17A:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4liy | FIBER PROTEIN (HumanmastadenovirusB) |
PF00541(Adeno_knob) | 3 | TRP A 290ILE A 145SER A 154 | None | 0.96A | 5gqbA-4liyA:undetectable | 5gqbA-4liyA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mcj | UNCHARACTERIZEDPROTEIN (Parabacteroidesdistasonis) |
PF15891(Nuc_deoxyri_tr2) | 3 | TRP A 60ILE A 115SER A 121 | None | 0.98A | 5gqbA-4mcjA:2.1 | 5gqbA-4mcjA:14.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o9d | RIK1-ASSOCIATEDFACTOR 1 (Schizosaccharomycespombe) |
no annotation | 3 | TRP B 573ILE B 549SER B 506 | None | 0.78A | 5gqbA-4o9dB:undetectable | 5gqbA-4o9dB:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ovy | HALOACIDDEHALOGENASE DOMAINPROTEIN HYDROLASE (Planctopiruslimnophila) |
PF12710(HAD) | 3 | TRP A 71ILE A 182SER A 184 | NoneNoneEDO A 407 ( 4.3A) | 1.01A | 5gqbA-4ovyA:undetectable | 5gqbA-4ovyA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p7l | POLY-BETA-1,6-N-ACETYL-D-GLUCOSAMINEN-DEACETYLASE (Escherichiacoli) |
PF14883(GHL13) | 3 | TRP A 387ILE A 340SER A 393 | None | 0.87A | 5gqbA-4p7lA:17.0 | 5gqbA-4p7lA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p8b | TRAP-TYPETRANSPORTER,PERIPLASMICCOMPONENT (Cupriavidusnecator) |
PF03480(DctP) | 3 | TRP A 101ILE A 91SER A 36 | None | 0.92A | 5gqbA-4p8bA:undetectable | 5gqbA-4p8bA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qex | ERYTHROCYTE-BINDINGANTIGEN-175 (Plasmodiumfalciparum) |
PF05424(Duffy_binding) | 3 | TRP A 463ILE A 377SER A 380 | None | 0.84A | 5gqbA-4qexA:undetectable | 5gqbA-4qexA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qg5 | PUTATIVEPHOSPHOGLUCOMUTASE (Leishmaniamajor) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 3 | TRP A 372ILE A 407SER A 95 | None | 1.03A | 5gqbA-4qg5A:undetectable | 5gqbA-4qg5A:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r0s | PROTEIN TYROSINEPHOSPHATASE TPBA (Pseudomonasaeruginosa) |
PF03162(Y_phosphatase2) | 3 | TRP A 89ILE A 47SER A 59 | None | 0.77A | 5gqbA-4r0sA:undetectable | 5gqbA-4r0sA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uv6 | APICAL MEROZOITEANTIGEN 1 (Plasmodiumknowlesi) |
PF02430(AMA-1) | 3 | TRP A 344ILE A 72SER A 290 | None | 1.04A | 5gqbA-4uv6A:undetectable | 5gqbA-4uv6A:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w8b | EXO-XYLOGLUCANASE (unculturedbacterium) |
PF00150(Cellulase) | 3 | TRP A 171ILE A 200SER A 197 | BGC A 603 ( 4.3A)NoneNone | 1.04A | 5gqbA-4w8bA:11.6 | 5gqbA-4w8bA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xmm | NUCLEOPORIN SEH1 (Saccharomycescerevisiae) |
PF00400(WD40) | 3 | TRP C 51ILE C 58SER C 74 | None | 0.94A | 5gqbA-4xmmC:undetectable | 5gqbA-4xmmC:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xz6 | GLYCINEBETAINE/PROLINE ABCTRANSPORTER,PERIPLASMICSUBSTRATE-BINDINGPROTEIN (Ruegeriapomeroyi) |
PF04069(OpuAC) | 3 | TRP A 55ILE A 52SER A 62 | TMO A 401 ( 3.8A)NoneNone | 0.98A | 5gqbA-4xz6A:undetectable | 5gqbA-4xz6A:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bq9 | UNCHARACTERIZEDPROTEIN (Legionellapneumophila) |
PF12252(SidE) | 3 | TRP A 481ILE A 492SER A 494 | None | 0.99A | 5gqbA-5bq9A:undetectable | 5gqbA-5bq9A:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cow | PUTATIVEUNCHARACTERIZEDPROTEIN (Caenorhabditisremanei) |
no annotation | 3 | TRP A 343ILE A 317SER A 438 | None | 0.85A | 5gqbA-5cowA:undetectable | 5gqbA-5cowA:18.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5df0 | AC-CHIA (Autographacalifornicamultiplenucleopolyhedrovirus) |
PF00704(Glyco_hydro_18)PF08329(ChitinaseA_N) | 3 | TRP A 157ILE A 197SER A 200 | None | 0.68A | 5gqbA-5df0A:62.6 | 5gqbA-5df0A:61.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e3b | MACRODOMAIN PROTEIN (Streptomycescoelicolor) |
no annotation | 3 | TRP A 134ILE A 4SER A 142 | None | 1.01A | 5gqbA-5e3bA:undetectable | 5gqbA-5e3bA:15.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ekd | TRYPTOPHAN--TRNALIGASE,MITOCHONDRIAL (Homo sapiens) |
PF00579(tRNA-synt_1b) | 3 | TRP A 59ILE A 104SER A 109 | None | 1.01A | 5gqbA-5ekdA:undetectable | 5gqbA-5ekdA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fp1 | TONB-DEPENDENTSIDEROPHORE RECEPTOR (Acinetobacterbaumannii) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 3 | TRP A 314ILE A 364SER A 372 | None | 1.00A | 5gqbA-5fp1A:undetectable | 5gqbA-5fp1A:21.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5gpr | CHITINASE (Ostriniafurnacalis) |
PF00704(Glyco_hydro_18)PF08329(ChitinaseA_N) | 3 | TRP A 160ILE A 200SER A 203 | TRP A 160 ( 0.5A)ILE A 200 ( 0.7A)SER A 203 ( 0.0A) | 0.27A | 5gqbA-5gprA:67.9 | 5gqbA-5gprA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hiu | GTPASEACTIVATOR-LIKEPROTEIN (Chaetomiumthermophilum) |
PF11864(DUF3384) | 3 | TRP A 129ILE A 136SER A 148 | TRP A 129 ( 0.5A)ILE A 136 ( 0.6A)SER A 148 ( 0.0A) | 0.91A | 5gqbA-5hiuA:undetectable | 5gqbA-5hiuA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i61 | POTENTIALRNA-DEPENDENT RNAPOLYMERASE (Humanpicobirnavirus) |
no annotation | 3 | TRP B 51ILE B 58SER B 57 | None | 1.02A | 5gqbA-5i61B:undetectable | 5gqbA-5i61B:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ioj | HALOALKYLPHOSPHORUSHYDROLASE (Sphingobium sp.TCM1) |
no annotation | 3 | TRP A 531ILE A 158SER A 220 | None | 0.72A | 5gqbA-5iojA:undetectable | 5gqbA-5iojA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jvv | BETA-1,3-GLUCOSYLTRANSFERASE (Paecilomycessp.'thermophila') |
no annotation | 3 | TRP B 199ILE B 210SER B 209 | None | 0.96A | 5gqbA-5jvvB:undetectable | 5gqbA-5jvvB:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k7l | POTASSIUMVOLTAGE-GATEDCHANNEL SUBFAMILY HMEMBER 1 (Rattusnorvegicus) |
PF00027(cNMP_binding)PF00520(Ion_trans)PF13426(PAS_9) | 3 | TRP A 370ILE A 456SER A 433 | None | 0.94A | 5gqbA-5k7lA:undetectable | 5gqbA-5k7lA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kkb | MANNOSYL-OLIGOSACCHARIDE1,2-ALPHA-MANNOSIDASE IA (Mus musculus) |
PF01532(Glyco_hydro_47) | 3 | TRP A 326ILE A 324SER A 322 | None | 0.99A | 5gqbA-5kkbA:undetectable | 5gqbA-5kkbA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lq6 | VIRULENCE PROTEINVSDE (Salmonellaenterica) |
PF05563(SpvD) | 3 | TRP A 184ILE A 157SER A 160 | None | 0.92A | 5gqbA-5lq6A:undetectable | 5gqbA-5lq6A:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ov3 | RETINOBLASTOMA-BINDING PROTEIN 5 (Mus musculus) |
no annotation | 3 | TRP A 93ILE A 89SER A 85 | None | 1.00A | 5gqbA-5ov3A:undetectable | 5gqbA-5ov3A:12.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t2x | UNCHARACTERIZEDPROTEIN LPG1670 (Legionellapneumophila) |
no annotation | 3 | TRP A 237ILE A 217SER A 213 | None | 0.86A | 5gqbA-5t2xA:undetectable | 5gqbA-5t2xA:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tii | 3-OXOACYL-ACPREDUCTASE (unculturedbacterium) |
PF13561(adh_short_C2) | 3 | TRP A 231ILE A 140SER A 138 | None | 0.87A | 5gqbA-5tiiA:3.5 | 5gqbA-5tiiA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wjc | KINETOCHORE PROTEINMIS16 (Schizosaccharomycespombe) |
no annotation | 3 | TRP A 417ILE A 340SER A 334 | None | 0.99A | 5gqbA-5wjcA:undetectable | 5gqbA-5wjcA:10.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wve | APOPTOTICPROTEASE-ACTIVATINGFACTOR 1 (Homo sapiens) |
PF00400(WD40)PF00931(NB-ARC) | 3 | TRP A1061ILE A1027SER A1021 | None | 0.87A | 5gqbA-5wveA:undetectable | 5gqbA-5wveA:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zl9 | CHITINASE AB (Serratiamarcescens) |
no annotation | 3 | TRP A 167ILE A 207SER A 210 | GOL A 707 (-4.0A)GOL A 707 ( 4.5A)GOL A 707 (-3.2A) | 0.59A | 5gqbA-5zl9A:64.5 | 5gqbA-5zl9A:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zl9 | CHITINASE AB (Serratiamarcescens) |
no annotation | 3 | TRP A 314ILE A 312SER A 361 | None | 0.90A | 5gqbA-5zl9A:64.5 | 5gqbA-5zl9A:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b9g | ATLASTIN-1 (Homo sapiens) |
no annotation | 3 | TRP B 303ILE B 173SER B 211 | None | 0.59A | 5gqbA-6b9gB:undetectable | 5gqbA-6b9gB:10.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c26 | DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEINGLYCOSYLTRANSFERASESUBUNIT STT3 (Saccharomycescerevisiae) |
no annotation | 3 | TRP A 598ILE A 602SER A 552 | None | 0.98A | 5gqbA-6c26A:undetectable | 5gqbA-6c26A:9.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c2j | RNAP2 (Escherichiavirus N4) |
no annotation | 3 | TRP B 183ILE B 247SER B 246 | None | 0.90A | 5gqbA-6c2jB:undetectable | 5gqbA-6c2jB:8.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ces | RAS-RELATEDGTP-BINDING PROTEINA (Homo sapiens) |
no annotation | 3 | TRP A 165ILE A 26SER A 22 | GNP A 500 (-4.6A)NoneGNP A 500 (-4.4A) | 0.92A | 5gqbA-6cesA:3.7 | 5gqbA-6cesA:9.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fyd | PUTATIVEFAD-DEPENDENTOXYGENASE ENCM (Streptomycesmaritimus) |
no annotation | 3 | TRP A 275ILE A 289SER A 288 | None | 1.02A | 5gqbA-6fydA:undetectable | 5gqbA-6fydA:9.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gh2 | LAMINARIBIOSEPHOSPHORYLASE (Paenibacillussp. YM1) |
no annotation | 3 | TRP A 342ILE A 776SER A 774 | None | 0.85A | 5gqbA-6gh2A:undetectable | 5gqbA-6gh2A:8.07 |