SIMILAR PATTERNS OF AMINO ACIDS FOR 5GQB_A_GCSA604_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 TRP A 167
TRP A 275
THR A 276
LEU A 277
 SN5  A1563 ( 4.0A)
SN5  A1566 (-3.3A)
SN5  A1563 ( 3.3A)
None
 0.30A 5gqbA-2wk2A:
65.8		 5gqbA-2wk2A:
72.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 TRP A 168
TRP A 275
THR A 276
LEU A 277
 None
 0.38A 5gqbA-3b9eA:
38.1		 5gqbA-3b9eA:
50.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 TRP A 157
TRP A 265
THR A 266
LEU A 267
 None
NAG  A 603 ( 3.9A)
SN5  A 604 (-3.1A)
None
 0.36A 5gqbA-5df0A:
62.6		 5gqbA-5df0A:
61.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 TRP A 160
TRP A 268
THR A 269
LEU A 270
 TRP  A 160 ( 0.5A)
TRP  A 268 ( 0.5A)
THR  A 269 ( 0.8A)
LEU  A 270 ( 0.6A)
 0.16A 5gqbA-5gprA:
67.9		 5gqbA-5gprA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 4 TRP A 167
TRP A 275
THR A 276
LEU A 277
 GOL  A 707 (-4.0A)
None
None
None
 0.23A 5gqbA-5zl9A:
64.5		 5gqbA-5zl9A:
24.00