SIMILAR PATTERNS OF AMINO ACIDS FOR 5GQB_A_GCSA602_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bqg | D-GLUCARATEDEHYDRATASE (Pseudomonasputida) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | TRP A 246GLU A 222ASP A 241 | None | 0.62A | 5gqbA-1bqgA:5.7 | 5gqbA-1bqgA:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e6z | CHITINASE B (Serratiamarcescens) |
PF00704(Glyco_hydro_18) | 3 | TRP A 97GLU A 144ASP A 215 | NAG A 503 ( 3.7A)NGO A 502 (-3.4A)NGO A 502 ( 3.1A) | 0.35A | 5gqbA-1e6zA:34.8 | 5gqbA-1e6zA:23.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f26 | NITRIC OXIDEREDUCTASE (Fusariumoxysporum) |
PF00067(p450) | 3 | TRP A 337GLU A 277ASP A 341 | None | 0.99A | 5gqbA-1f26A:undetectable | 5gqbA-1f26A:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1flg | PROTEIN(QUINOPROTEINETHANOLDEHYDROGENASE) (Pseudomonasaeruginosa) |
PF01011(PQQ)PF13360(PQQ_2) | 3 | TRP A 370GLU A 383ASP A 313 | None | 1.05A | 5gqbA-1flgA:undetectable | 5gqbA-1flgA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h39 | SQUALENE--HOPENECYCLASE (Alicyclobacillusacidocaldarius) |
PF13243(SQHop_cyclase_C)PF13249(SQHop_cyclase_N) | 3 | TRP A 302GLU A 291ASP A 57 | None | 0.70A | 5gqbA-1h39A:undetectable | 5gqbA-1h39A:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hkk | CHITOTRIOSIDASE-1 (Homo sapiens) |
PF00704(Glyco_hydro_18) | 3 | TRP A 99GLU A 140ASP A 213 | NAA A1390 ( 4.3A)AMI A1388 ( 3.3A)AMI A1388 ( 2.9A) | 0.35A | 5gqbA-1hkkA:44.5 | 5gqbA-1hkkA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1itx | GLYCOSYL HYDROLASE (Bacilluscirculans) |
PF00704(Glyco_hydro_18) | 3 | TRP A 164GLU A 204ASP A 280 | NoneGOL A1007 (-3.7A)None | 0.23A | 5gqbA-1itxA:46.7 | 5gqbA-1itxA:29.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jct | GLUCARATEDEHYDRATASE (Escherichiacoli) |
PF13378(MR_MLE_C) | 3 | TRP A 240GLU A 216ASP A 235 | NoneNone MG A 498 ( 2.6A) | 0.53A | 5gqbA-1jctA:5.2 | 5gqbA-1jctA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kfw | CHITINASE B (Arthrobactersp. TAD20) |
PF00704(Glyco_hydro_18) | 3 | TRP A 136GLU A 192ASP A 272 | NoneGOL A 530 (-3.9A)GOL A 530 (-3.7A) | 0.31A | 5gqbA-1kfwA:41.3 | 5gqbA-1kfwA:26.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t5o | TRANSLATIONINITIATION FACTOREIF2B, SUBUNIT DELTA (Archaeoglobusfulgidus) |
PF01008(IF-2B) | 3 | TRP A 272GLU A 332ASP A 239 | None | 0.73A | 5gqbA-1t5oA:2.1 | 5gqbA-1t5oA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tz6 | PUTATIVE SUGARKINASE (Salmonellaenterica) |
PF00294(PfkB) | 3 | TRP A 166GLU A 171ASP A 134 | None | 1.00A | 5gqbA-1tz6A:undetectable | 5gqbA-1tz6A:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wb0 | CHITOTRIOSIDASE 1 (Homo sapiens) |
PF00704(Glyco_hydro_18) | 3 | TRP A 99GLU A 140ASP A 213 | None | 0.37A | 5gqbA-1wb0A:44.2 | 5gqbA-1wb0A:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wno | CHITINASE (Aspergillusfumigatus) |
PF00704(Glyco_hydro_18) | 3 | TRP A 99GLU A 139ASP A 208 | None | 0.50A | 5gqbA-1wnoA:43.3 | 5gqbA-1wnoA:24.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eve | HYPOTHETICAL PROTEINPSPTO5229 (Pseudomonassyringae groupgenomosp. 3) |
PF01878(EVE) | 3 | TRP A 142GLU A 46ASP A 103 | None | 1.06A | 5gqbA-2eveA:undetectable | 5gqbA-2eveA:13.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g6t | UNCHARACTERIZEDPROTEIN, HOMOLOGHI1244 FROMHAEMOPHILUSINFLUENZAE (Clostridiumacetobutylicum) |
PF08942(DUF1919) | 3 | TRP A 7GLU A 77ASP A 51 | None | 1.02A | 5gqbA-2g6tA:undetectable | 5gqbA-2g6tA:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h0b | NEUREXIN-1-ALPHA (Bos taurus) |
PF02210(Laminin_G_2) | 3 | TRP A 367GLU A 281ASP A 369 | None | 0.98A | 5gqbA-2h0bA:undetectable | 5gqbA-2h0bA:15.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2le1 | UNCHARACTERIZEDPROTEIN (Thermobifidafusca) |
PF10604(Polyketide_cyc2) | 3 | TRP A 18GLU A 70ASP A 23 | None | 0.83A | 5gqbA-2le1A:undetectable | 5gqbA-2le1A:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o0h | DNA PACKAGINGPROTEIN GP17 (Escherichiavirus T4) |
PF03237(Terminase_6) | 3 | TRP A 221GLU A 208ASP A 201 | None | 0.99A | 5gqbA-2o0hA:undetectable | 5gqbA-2o0hA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q3h | RAS HOMOLOG GENEFAMILY, MEMBER U (Homo sapiens) |
PF00071(Ras) | 3 | TRP A 143GLU A 146ASP A 108 | None | 1.04A | 5gqbA-2q3hA:2.6 | 5gqbA-2q3hA:15.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qom | SERINE PROTEASE ESPP (Escherichiacoli) |
PF03797(Autotransporter) | 3 | TRP A1166GLU A1168ASP A1031 | None | 1.02A | 5gqbA-2qomA:undetectable | 5gqbA-2qomA:20.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wk2 | CHITINASE A (Serratiamarcescens) |
PF00704(Glyco_hydro_18)PF08329(ChitinaseA_N) | 3 | TRP A 275GLU A 315ASP A 391 | SN5 A1566 (-3.3A)SN5 A1566 ( 2.9A)NGT A1565 (-2.9A) | 0.18A | 5gqbA-2wk2A:65.8 | 5gqbA-2wk2A:72.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x40 | BETA-GLUCOSIDASE (Thermotoganeapolitana) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 3 | TRP A 687GLU A 195ASP A 678 | None | 0.97A | 5gqbA-2x40A:3.4 | 5gqbA-2x40A:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ybu | ACIDIC MAMMALIANCHITINASE (Homo sapiens) |
PF00704(Glyco_hydro_18) | 3 | TRP A 99GLU A 140ASP A 213 | CX9 A1399 ( 3.4A)CX9 A1398 (-3.7A)CX9 A1398 ( 4.4A) | 0.27A | 5gqbA-2ybuA:43.9 | 5gqbA-2ybuA:24.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ywv | PHOSPHORIBOSYLAMINOIMIDAZOLESUCCINOCARBOXAMIDESYNTHETASE (Geobacilluskaustophilus) |
PF01259(SAICAR_synt) | 3 | TRP A 203GLU A 110ASP A 176 | NoneNoneSO4 A 543 ( 4.6A) | 1.05A | 5gqbA-2ywvA:undetectable | 5gqbA-2ywvA:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b7f | GLYCOSYL HYDROLASE,BNR REPEAT (Cupriaviduspinatubonensis) |
no annotation | 3 | TRP A 293GLU A 370ASP A 288 | NoneEDO A 400 ( 3.2A)EDO A 400 (-3.6A) | 0.97A | 5gqbA-3b7fA:undetectable | 5gqbA-3b7fA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c1a | PUTATIVEOXIDOREDUCTASE (Magnetospirillummagnetotacticum) |
PF01408(GFO_IDH_MocA) | 3 | TRP A 263GLU A 153ASP A 245 | None | 0.95A | 5gqbA-3c1aA:undetectable | 5gqbA-3c1aA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c26 | PUTATIVEACETYLTRANSFERASETA0821 (Thermoplasmaacidophilum) |
PF00583(Acetyltransf_1) | 3 | TRP A 55GLU A 77ASP A 177 | EDO A 269 (-4.9A)EDO A 269 ( 4.8A)None | 1.04A | 5gqbA-3c26A:undetectable | 5gqbA-3c26A:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dbk | ELASTASE (Pseudomonasaeruginosa) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 3 | TRP A 90GLU A 249ASP A 243 | None | 1.01A | 5gqbA-3dbkA:undetectable | 5gqbA-3dbkA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e23 | UNCHARACTERIZEDPROTEIN RPA2492 (Rhodopseudomonaspalustris) |
PF08241(Methyltransf_11) | 3 | TRP A 163GLU A 170ASP A 118 | SO4 A 224 ( 4.3A)NoneNone | 1.06A | 5gqbA-3e23A:undetectable | 5gqbA-3e23A:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fg6 | ADSEVERIN (Homo sapiens) |
PF00626(Gelsolin) | 3 | TRP A 715GLU A 642ASP A 638 | None | 0.95A | 5gqbA-3fg6A:undetectable | 5gqbA-3fg6A:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g6l | CHITINASE (Clonostachysrosea) |
PF00704(Glyco_hydro_18) | 3 | TRP A 134GLU A 174ASP A 243 | None | 0.73A | 5gqbA-3g6lA:43.8 | 5gqbA-3g6lA:25.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7l | CHROMODOMAIN-CONTAININGPROTEIN 1 (Schizosaccharomycespombe) |
PF00385(Chromo) | 3 | TRP A 44GLU A 55ASP A 20 | None | 0.91A | 5gqbA-3g7lA:undetectable | 5gqbA-3g7lA:7.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyc | PUTATIVE GLYCOSIDEHYDROLASE (Parabacteroidesdistasonis) |
PF12876(Cellulase-like) | 3 | TRP A 141GLU A 331ASP A 183 | None | 0.91A | 5gqbA-3gycA:6.5 | 5gqbA-3gycA:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mqt | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Shewanellapealeana) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | TRP A 311GLU A 334ASP A 206 | None MG A1243 ( 4.9A) MG A1243 (-3.3A) | 0.81A | 5gqbA-3mqtA:8.5 | 5gqbA-3mqtA:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mzn | GLUCARATEDEHYDRATASE (Chromohalobactersalexigens) |
PF13378(MR_MLE_C) | 3 | TRP A 236GLU A 212ASP A 231 | None | 0.60A | 5gqbA-3mznA:6.2 | 5gqbA-3mznA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nua | PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (Clostridiumperfringens) |
PF01259(SAICAR_synt) | 3 | TRP A 202GLU A 110ASP A 176 | NoneNoneAMP A 242 (-3.4A) | 1.06A | 5gqbA-3nuaA:undetectable | 5gqbA-3nuaA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nxl | GLUCARATEDEHYDRATASE (Burkholderialata) |
PF13378(MR_MLE_C) | 3 | TRP A 260GLU A 236ASP A 255 | NoneNone MG A 476 (-2.8A) | 0.50A | 5gqbA-3nxlA:5.1 | 5gqbA-3nxlA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nzg | PUTATIVE RACEMASE (Pseudovibriosp. JE062) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | TRP A 316GLU A 339ASP A 211 | NoneGOL A 601 (-2.6A) MG A 507 ( 2.7A) | 1.00A | 5gqbA-3nzgA:6.2 | 5gqbA-3nzgA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p0w | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Ralstoniapickettii) |
PF13378(MR_MLE_C) | 3 | TRP A 256GLU A 232ASP A 251 | NoneNone MG A 471 ( 2.6A) | 0.57A | 5gqbA-3p0wA:5.2 | 5gqbA-3p0wA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pfr | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Actinobacillussuccinogenes) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | TRP A 241GLU A 217ASP A 236 | NoneNone MG A 456 ( 2.7A) | 0.47A | 5gqbA-3pfrA:5.5 | 5gqbA-3pfrA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qok | PUTATIVE CHITINASEII (Klebsiellapneumoniae) |
PF00704(Glyco_hydro_18) | 3 | TRP A 114GLU A 153ASP A 223 | None | 0.43A | 5gqbA-3qokA:36.8 | 5gqbA-3qokA:24.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3slt | SERINE PROTEASE ESPP (Escherichiacoli) |
PF03797(Autotransporter) | 3 | TRP A1166GLU A1168ASP A1031 | None | 0.96A | 5gqbA-3sltA:undetectable | 5gqbA-3sltA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t0q | AGR253WP (Eremotheciumgossypii) |
PF00225(Kinesin) | 3 | TRP A 490GLU A 597ASP A 443 | None | 1.03A | 5gqbA-3t0qA:undetectable | 5gqbA-3t0qA:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ujz | METALLOPROTEASE STCE (Escherichiacoli) |
PF10462(Peptidase_M66) | 3 | TRP A 478GLU A 263ASP A 481 | None | 0.87A | 5gqbA-3ujzA:undetectable | 5gqbA-3ujzA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3va8 | PROBABLE DEHYDRATASE (Fusariumgraminearum) |
PF13378(MR_MLE_C) | 3 | TRP A 225GLU A 201ASP A 220 | NoneNone MG A 425 ( 2.4A) | 0.67A | 5gqbA-3va8A:3.8 | 5gqbA-3va8A:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vdg | PROBABLE GLUCARATEDEHYDRATASE (Mycolicibacteriumsmegmatis) |
PF13378(MR_MLE_C) | 3 | TRP A 227GLU A 203ASP A 222 | NoneNone NA A 502 (-2.9A) | 0.60A | 5gqbA-3vdgA:5.4 | 5gqbA-3vdgA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w4r | CHITINASE (Ostriniafurnacalis) |
PF00704(Glyco_hydro_18) | 3 | TRP A 107GLU A 148ASP A 218 | None | 0.41A | 5gqbA-3w4rA:43.0 | 5gqbA-3w4rA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w5n | PUTATIVERHAMNOSIDASE (Streptomycesavermitilis) |
PF05592(Bac_rhamnosid)PF08531(Bac_rhamnosid_N)PF17389(Bac_rhamnosid6H)PF17390(Bac_rhamnosid_C) | 3 | TRP A 107GLU A 109ASP A 360 | None | 0.95A | 5gqbA-3w5nA:3.5 | 5gqbA-3w5nA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wl1 | CHITINASE (Ostriniafurnacalis) |
PF00704(Glyco_hydro_18) | 3 | TRP A 107GLU A 148ASP A 218 | NAG A 505 ( 3.4A)NAG A 501 (-2.7A)NAG A 501 ( 3.2A) | 0.41A | 5gqbA-3wl1A:43.1 | 5gqbA-3wl1A:24.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zlb | PHOSPHOGLYCERATEKINASE (Streptococcuspneumoniae) |
PF00162(PGK) | 3 | TRP A 139GLU A 121ASP A 132 | None | 1.07A | 5gqbA-3zlbA:undetectable | 5gqbA-3zlbA:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a5q | CHI1 (Yersiniaentomophaga) |
PF00704(Glyco_hydro_18) | 3 | TRP A 215GLU A 256ASP A 326 | None | 0.78A | 5gqbA-4a5qA:36.3 | 5gqbA-4a5qA:26.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dhg | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Thermobisporabispora) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | TRP A 222GLU A 198ASP A 217 | None | 0.55A | 5gqbA-4dhgA:5.5 | 5gqbA-4dhgA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dws | CHI2 (Yersiniaentomophaga) |
PF00704(Glyco_hydro_18) | 3 | TRP A 308GLU A 349ASP A 425 | None | 0.61A | 5gqbA-4dwsA:36.8 | 5gqbA-4dwsA:29.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dyk | AMIDOHYDROLASE (Pseudomonasaeruginosa) |
PF01979(Amidohydro_1) | 3 | TRP A 298GLU A 295ASP A 341 | None | 1.02A | 5gqbA-4dykA:6.7 | 5gqbA-4dykA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g8t | GLUCARATEDEHYDRATASE (Actinobacillussuccinogenes) |
PF13378(MR_MLE_C) | 3 | TRP A 236GLU A 212ASP A 231 | NoneNone NA A 502 (-2.3A) | 0.55A | 5gqbA-4g8tA:3.2 | 5gqbA-4g8tA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gyp | GLUCARATEDEHYDRATASE-RELATEDPROTEIN (Escherichiacoli) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | TRP C 239GLU C 215ASP C 234 | None | 0.64A | 5gqbA-4gypC:5.4 | 5gqbA-4gypC:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hn8 | D-GLUCARATEDEHYDRATASE (Pseudomonasmendocina) |
PF13378(MR_MLE_C) | 3 | TRP A 257GLU A 233ASP A 252 | None | 0.55A | 5gqbA-4hn8A:5.0 | 5gqbA-4hn8A:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hyr | GLUCARATEDEHYDRATASE (Acidaminococcusintestini) |
PF13378(MR_MLE_C) | 3 | TRP A 236GLU A 212ASP A 231 | None | 0.55A | 5gqbA-4hyrA:6.4 | 5gqbA-4hyrA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jdq | SLR1964 PROTEIN (Synechocystissp. PCC 6803) |
no annotation | 3 | TRP A 9GLU A 13ASP A 98 | None | 0.92A | 5gqbA-4jdqA:undetectable | 5gqbA-4jdqA:13.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mae | METHANOLDEHYDROGENASE (Methylacidiphilumfumariolicum) |
PF13360(PQQ_2) | 3 | TRP A 351GLU A 364ASP A 296 | None | 1.03A | 5gqbA-4maeA:undetectable | 5gqbA-4maeA:24.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n5x | CALCIUM-BINDINGMITOCHONDRIALCARRIER PROTEINSCAMC-1 (Homo sapiens) |
PF13499(EF-hand_7) | 3 | TRP A 144GLU A 88ASP A 149 | None | 0.87A | 5gqbA-4n5xA:undetectable | 5gqbA-4n5xA:16.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p47 | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Ochrobactrumanthropi) |
PF03480(DctP) | 3 | TRP A 249GLU A 261ASP A 254 | None | 1.04A | 5gqbA-4p47A:undetectable | 5gqbA-4p47A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pj3 | INTRON-BINDINGPROTEIN AQUARIUS (Homo sapiens) |
PF13086(AAA_11)PF13087(AAA_12)PF16399(Aquarius_N) | 3 | TRP A 175GLU A 186ASP A 315 | None | 1.01A | 5gqbA-4pj3A:undetectable | 5gqbA-4pj3A:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q22 | GLYCOSIDE HYDROLASEFAMILY 18 (Serratiaproteamaculans) |
PF00704(Glyco_hydro_18) | 3 | TRP A 114GLU A 153ASP A 223 | NoneACT A 502 (-3.8A)GOL A 504 (-2.7A) | 0.56A | 5gqbA-4q22A:36.8 | 5gqbA-4q22A:25.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rqo | L-SERINE DEHYDRATASE (Legionellapneumophila) |
PF03313(SDH_alpha)PF03315(SDH_beta) | 3 | TRP A 201GLU A 198ASP A 7 | None | 0.99A | 5gqbA-4rqoA:undetectable | 5gqbA-4rqoA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4txg | CHITINASE (Chromobacteriumviolaceum) |
PF00704(Glyco_hydro_18)PF06483(ChiC) | 3 | TRP A 255GLU A 314ASP A 398 | None CS A 803 (-2.9A) CS A 812 (-4.0A) | 0.50A | 5gqbA-4txgA:32.5 | 5gqbA-4txgA:24.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w5u | CHITINASE (Streptomycesthermoviolaceus) |
no annotation | 3 | TRP B 142GLU B 183ASP B 251 | MLI B 501 ( 3.8A)NoneMLI B 501 ( 4.7A) | 0.30A | 5gqbA-4w5uB:45.4 | 5gqbA-4w5uB:29.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w7g | DYNEIN LIGHTINTERMEDIATE CHAIN (Chaetomiumthermophilum) |
PF05783(DLIC) | 3 | TRP A 159GLU A 158ASP A 117 | None | 1.02A | 5gqbA-4w7gA:undetectable | 5gqbA-4w7gA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x33 | DIPHTHAMIDEBIOSYNTHESIS PROTEIN3PROTEIN ATS1 (Saccharomycescerevisiae) |
PF00415(RCC1)PF05207(zf-CSL) | 3 | TRP B 229GLU B 271ASP A 5 | None | 0.99A | 5gqbA-4x33B:undetectable | 5gqbA-4x33B:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xqk | LLABIII (Lactococcuslactis) |
PF00271(Helicase_C)PF02384(N6_Mtase)PF04851(ResIII)PF13156(Mrr_cat_2) | 3 | TRP A1048GLU A1105ASP A1073 | None | 0.95A | 5gqbA-4xqkA:undetectable | 5gqbA-4xqkA:16.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yu5 | IMMUNE INHIBITOR A,METALLOPROTEASE (Bacillus cereus) |
PF05547(Peptidase_M6) | 3 | TRP A 405GLU A 649ASP A 657 | None | 0.94A | 5gqbA-4yu5A:undetectable | 5gqbA-4yu5A:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zcv | CALCIUM-BINDINGMITOCHONDRIALCARRIER PROTEINSCAMC-1 (Homo sapiens) |
PF13499(EF-hand_7) | 3 | TRP A 144GLU A 88ASP A 149 | None | 0.95A | 5gqbA-4zcvA:undetectable | 5gqbA-4zcvA:16.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zke | SUPERKILLER PROTEIN7 (Saccharomycescerevisiae) |
PF00009(GTP_EFTU) | 3 | TRP A 498GLU A 440ASP A 435 | TRP A 498 ( 0.5A)GLU A 440 ( 0.6A)ASP A 435 ( 0.6A) | 1.01A | 5gqbA-4zkeA:undetectable | 5gqbA-4zkeA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zmh | UNCHARACTERIZEDPROTEIN (Saccharophagusdegradans) |
PF15979(Glyco_hydro_115) | 3 | TRP A 487GLU A 484ASP A 168 | None | 1.03A | 5gqbA-4zmhA:4.2 | 5gqbA-4zmhA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ztu | DNA POLYMERASESUBUNIT GAMMA-2,MITOCHONDRIAL (Homo sapiens) |
PF03129(HGTP_anticodon) | 3 | TRP B 295GLU B 298ASP B 89 | None | 0.85A | 5gqbA-4ztuB:undetectable | 5gqbA-4ztuB:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c24 | HIV-1 REVERSETRANSCRIPTASE, P51SUBUNIT (Humanimmunodeficiencyvirus 1) |
PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb) | 3 | TRP B 414GLU B 413ASP B 76 | None | 0.97A | 5gqbA-5c24B:undetectable | 5gqbA-5c24B:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c53 | POL GAMMA B (Homo sapiens) |
PF03129(HGTP_anticodon) | 3 | TRP B 295GLU B 298ASP B 89 | None | 0.80A | 5gqbA-5c53B:undetectable | 5gqbA-5c53B:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cj5 | ALPHA-1,4-GLUCAN:MALTOSE-1-PHOSPHATEMALTOSYLTRANSFERASE (Mycolicibacteriumthermoresistibile) |
PF00128(Alpha-amylase)PF11896(DUF3416) | 3 | TRP A 350GLU A 394ASP A 310 | None | 1.03A | 5gqbA-5cj5A:11.4 | 5gqbA-5cj5A:21.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5df0 | AC-CHIA (Autographacalifornicamultiplenucleopolyhedrovirus) |
PF00704(Glyco_hydro_18)PF08329(ChitinaseA_N) | 3 | TRP A 265GLU A 305ASP A 382 | NAG A 603 ( 3.9A)58Y A 605 (-3.1A)58Y A 605 ( 3.0A) | 0.17A | 5gqbA-5df0A:62.6 | 5gqbA-5df0A:61.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dte | MONOSACCHARIDE-TRANSPORTING ATPASE (Actinobacillussuccinogenes) |
PF13407(Peripla_BP_4) | 3 | TRP A 200GLU A 69ASP A 118 | ALL A 401 (-3.6A)ALL A 401 (-3.3A)ALL A 401 (-3.0A) | 1.01A | 5gqbA-5dteA:undetectable | 5gqbA-5dteA:20.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5gpr | CHITINASE (Ostriniafurnacalis) |
PF00704(Glyco_hydro_18)PF08329(ChitinaseA_N) | 3 | TRP A 268GLU A 308ASP A 384 | TRP A 268 ( 0.5A)GLU A 308 ( 0.6A)ASP A 384 ( 0.5A) | 0.28A | 5gqbA-5gprA:67.9 | 5gqbA-5gprA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gzt | CHITINASE (Paenibacillussp. FPU-7) |
PF00704(Glyco_hydro_18) | 3 | TRP B 652GLU B 691ASP B 767 | None | 0.33A | 5gqbA-5gztB:41.7 | 5gqbA-5gztB:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gzt | CHITINASE (Paenibacillussp. FPU-7) |
PF00704(Glyco_hydro_18) | 3 | TRP B1138GLU B1177ASP B1253 | None | 0.45A | 5gqbA-5gztB:41.7 | 5gqbA-5gztB:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gzu | CHITINASE (Paenibacillussp. FPU-7) |
PF00704(Glyco_hydro_18) | 3 | TRP A 652GLU A 691ASP A 767 | None | 0.45A | 5gqbA-5gzuA:43.3 | 5gqbA-5gzuA:23.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gzu | CHITINASE (Paenibacillussp. FPU-7) |
PF00704(Glyco_hydro_18) | 3 | TRP A1138GLU A1177ASP A1253 | None | 0.34A | 5gqbA-5gzuA:43.3 | 5gqbA-5gzuA:23.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h0q | LIPID BINDINGPROTEIN (Grifolafrondosa) |
no annotation | 3 | TRP A 155GLU A 79ASP A 161 | None | 1.06A | 5gqbA-5h0qA:undetectable | 5gqbA-5h0qA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hyh | UNCHARACTERIZEDPROTEIN (Streptomycesvenezuelae) |
PF11583(AurF) | 3 | TRP A 82GLU A 71ASP A 87 | None | 0.86A | 5gqbA-5hyhA:undetectable | 5gqbA-5hyhA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i67 | PHOSPHOENOLPYRUVATECARBOXYKINASE [GTP] (Mycobacteriumtuberculosis) |
PF00821(PEPCK_C)PF17297(PEPCK_N) | 3 | TRP A 288GLU A 259ASP A 526 | None | 0.89A | 5gqbA-5i67A:undetectable | 5gqbA-5i67A:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ihx | TYROSINE--TRNALIGASE,MITOCHONDRIAL (Aspergillusnidulans) |
PF00579(tRNA-synt_1b) | 3 | TRP A 281GLU A 238ASP A 323 | None | 1.05A | 5gqbA-5ihxA:undetectable | 5gqbA-5ihxA:23.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jzw | AEROLYSIN (Aeromonashydrophila) |
PF01117(Aerolysin)PF03440(APT) | 3 | TRP A 359GLU A 84ASP A 7 | None | 0.84A | 5gqbA-5jzwA:undetectable | 5gqbA-5jzwA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mdq | CHITOPORIN (Vibrio harveyi) |
no annotation | 3 | TRP A 185GLU A 204ASP A 147 | NoneNone NA A 401 ( 4.7A) | 1.02A | 5gqbA-5mdqA:undetectable | 5gqbA-5mdqA:9.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n8n | EVPB FAMILY TYPE VISECRETION PROTEIN (Pseudomonasaeruginosa) |
no annotation | 3 | TRP B 138GLU B 181ASP B 236 | None | 0.99A | 5gqbA-5n8nB:undetectable | 5gqbA-5n8nB:10.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nf4 | MINOR FIMBRIUM TIPSUBUNIT MFA3 (Porphyromonasgingivalis) |
no annotation | 3 | TRP A 341GLU A 61ASP A 195 | None | 0.98A | 5gqbA-5nf4A:4.1 | 5gqbA-5nf4A:7.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5pfr | BROMODOMAIN ADJACENTTO ZINC FINGERDOMAIN PROTEIN 2B (Homo sapiens) |
PF00439(Bromodomain) | 3 | TRP A1965GLU A1927ASP A1869 | None | 0.96A | 5gqbA-5pfrA:undetectable | 5gqbA-5pfrA:13.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ukw | GLUCOSE-6-PHOSPHATE1-DEHYDROGENASE (Homo sapiens) |
PF00479(G6PD_N)PF02781(G6PD_C) | 3 | TRP A 53GLU A 94ASP A 58 | None | 0.83A | 5gqbA-5ukwA:undetectable | 5gqbA-5ukwA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xwq | FUNGAL CHITINASEFROM RHIZOMUCORMIEHEI (NATIVEPROTEIN) (Rhizomucormiehei) |
no annotation | 3 | TRP A 142GLU A 182ASP A 257 | None | 0.23A | 5gqbA-5xwqA:37.3 | 5gqbA-5xwqA:9.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y29 | INSECT GROUP IICHITINASE (Ostriniafurnacalis) |
no annotation | 3 | TRP A1691GLU A1733ASP A1804 | None | 0.12A | 5gqbA-5y29A:43.9 | 5gqbA-5y29A:10.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y2a | INSECT GROUP IICHITINASE (Ostriniafurnacalis) |
no annotation | 3 | TRP A2138GLU A2180ASP A2251 | None | 0.22A | 5gqbA-5y2aA:43.1 | 5gqbA-5y2aA:9.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zl9 | CHITINASE AB (Serratiamarcescens) |
no annotation | 3 | TRP A 275GLU A 315ASP A 393 | NoneGOL A 706 (-3.3A)GOL A 703 (-3.0A) | 0.21A | 5gqbA-5zl9A:64.5 | 5gqbA-5zl9A:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fgh | BROMODOMAIN ADJACENTTO ZINC FINGERDOMAIN PROTEIN 2A (Homo sapiens) |
no annotation | 3 | TRP A1894GLU A1856ASP A1798 | None | 0.98A | 5gqbA-6fghA:undetectable | 5gqbA-6fghA:8.62 |