SIMILAR PATTERNS OF AMINO ACIDS FOR 5G6S_H_RAUH400_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 SER A 353
GLN A 192
GLY A 193
VAL A 349
PHE A 518
 None
None
None
SCL  A 700 ( 4.6A)
None
 1.30A 5g6sE-1ebvA:
0.9
5g6sH-1ebvA:
1.5		 5g6sE-1ebvA:
18.78
5g6sH-1ebvA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)

(Escherichia
coli) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1) 		5 SER A 461
GLY A 485
VAL A 463
MET A 365
TYR A 528
 None
None
TPQ  A 466 ( 4.5A)
None
None
 1.46A 5g6sE-1qafA:
0.0
5g6sH-1qafA:
0.0		 5g6sE-1qafA:
18.36
5g6sH-1qafA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t 3-KETOACYL-COA
THIOLASE

(Pseudomonas
fragi) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 MET C 125
SER C 243
GLY C 152
MET C 130
PHE C 349
 None
ACO  C1003 (-3.5A)
None
ACO  C1003 ( 4.1A)
None
 1.49A 5g6sE-2d3tC:
0.2
5g6sH-2d3tC:
0.4		 5g6sE-2d3tC:
23.21
5g6sH-2d3tC:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		5 SER A 417
GLN A 865
VAL A 462
MET A 447
TYR A 891
 None
 1.42A 5g6sE-2yocA:
0.3
5g6sH-2yocA:
0.3		 5g6sE-2yocA:
15.78
5g6sH-2yocA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tij NUPC FAMILY PROTEIN

(Vibrio cholerae) 		PF01773
(Nucleos_tra2_N)
PF07662
(Nucleos_tra2_C)
PF07670
(Gate) 		5 MET A 266
SER A 337
MET A 195
GLY A 191
VAL A 334
 None
 1.10A 5g6sE-3tijA:
0.9
5g6sH-3tijA:
0.9		 5g6sE-3tijA:
24.01
5g6sH-3tijA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j90 RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12741
(SusD-like) 		5 MET A 145
GLN A  70
GLY A 105
VAL A 115
MET A 148
 None
 1.34A 5g6sE-5j90A:
0.0
5g6sH-5j90A:
0.0		 5g6sE-5j90A:
20.08
5g6sH-5j90A:
20.08