SIMILAR PATTERNS OF AMINO ACIDS FOR 5G6S_C_RAUC400

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cij PROTEIN (HALOALKANE
DEHALOGENASE)

(Xanthobacter
autotrophicus) 		PF00561
(Abhydrolase_1) 		5 MET A  66
TYR A  63
GLN A 123
GLY A 257
VAL A 121
 None
 1.33A 5g6sB-1cijA:
undetectable
5g6sC-1cijA:
undetectable		 5g6sB-1cijA:
22.51
5g6sC-1cijA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m41 FMNH2-DEPENDENT
ALKANESULFONATE
MONOOXYGENASE

(Escherichia
coli) 		PF00296
(Bac_luciferase) 		5 TYR A 128
SER A 179
VAL A 181
TYR A 193
PHE A 175
 None
 1.18A 5g6sB-1m41A:
undetectable
5g6sC-1m41A:
undetectable		 5g6sB-1m41A:
23.54
5g6sC-1m41A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)

(Escherichia
coli) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1) 		5 SER A 461
GLY A 485
VAL A 463
MET A 365
TYR A 528
 None
None
TPQ  A 466 ( 4.5A)
None
None
 1.45A 5g6sB-1qafA:
undetectable
5g6sC-1qafA:
undetectable		 5g6sB-1qafA:
18.36
5g6sC-1qafA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0m TRIOSEPHOSPHATE
ISOMERASE

(Thermoproteus
tenax) 		PF00121
(TIM)
PF05690
(ThiG) 		5 SER A  54
GLN A  53
GLY A  85
VAL A  22
LEU A  48
 None
 1.11A 5g6sB-1w0mA:
undetectable
5g6sC-1w0mA:
undetectable		 5g6sB-1w0mA:
26.43
5g6sC-1w0mA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 TRP A 168
TYR A 123
GLY A 195
VAL A 121
LEU A 177
 None
None
GOL  A 755 ( 3.8A)
None
None
 1.45A 5g6sB-1yr2A:
undetectable
5g6sC-1yr2A:
undetectable		 5g6sB-1yr2A:
19.34
5g6sC-1yr2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 GLY A 557
VAL A 548
LEU A 555
TYR A 535
PHE A 346
 None
 1.45A 5g6sB-2fonA:
1.0
5g6sC-2fonA:
undetectable		 5g6sB-2fonA:
18.91
5g6sC-2fonA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermotoga
maritima) 		PF00342
(PGI) 		5 SER A 259
GLN A 298
GLY A 297
LEU A 283
MET A 404
 None
 1.45A 5g6sB-2q8nA:
2.1
5g6sC-2q8nA:
2.1		 5g6sB-2q8nA:
19.40
5g6sC-2q8nA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca) 		PF04672
(Methyltransf_19) 		5 GLN A 229
GLY A 231
VAL A 177
LEU A 191
MET A 193
 None
 1.45A 5g6sB-2qe6A:
2.6
5g6sC-2qe6A:
2.6		 5g6sB-2qe6A:
24.13
5g6sC-2qe6A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt0 HALOALKANE
DEHALOGENASE

(Plesiocystis
pacifica) 		PF00561
(Abhydrolase_1) 		5 MET A  65
TYR A  62
GLN A 122
GLY A 246
VAL A 120
 None
 1.47A 5g6sB-2xt0A:
undetectable
5g6sC-2xt0A:
undetectable		 5g6sB-2xt0A:
21.82
5g6sC-2xt0A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		5 SER A 417
GLN A 865
VAL A 462
MET A 447
TYR A 891
 None
 1.39A 5g6sB-2yocA:
undetectable
5g6sC-2yocA:
undetectable		 5g6sB-2yocA:
15.78
5g6sC-2yocA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d23 3C-LIKE PROTEINASE

(Human
coronavirus
HKU1) 		no annotation 5 TYR B  54
MET B 162
GLN B 164
GLY B 146
LEU B  27
 None
 1.46A 5g6sB-3d23B:
undetectable
5g6sC-3d23B:
undetectable		 5g6sB-3d23B:
22.26
5g6sC-3d23B:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddu PROLYL ENDOPEPTIDASE

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 TYR A 630
GLY A 557
VAL A 620
LEU A 635
MET A 633
 None
 1.46A 5g6sB-3dduA:
undetectable
5g6sC-3dduA:
undetectable		 5g6sB-3dduA:
17.63
5g6sC-3dduA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwc METALLOCARBOXYPEPTID
ASE

(Trypanosoma
cruzi) 		PF02074
(Peptidase_M32) 		5 MET A 313
GLY A 307
VAL A 338
LEU A 261
PHE A 256
 None
 1.32A 5g6sB-3dwcA:
0.9
5g6sC-3dwcA:
undetectable		 5g6sB-3dwcA:
21.53
5g6sC-3dwcA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 5 TYR X 141
SER X  16
GLY X 145
VAL X  10
LEU X 167
 None
 1.19A 5g6sB-3kvnX:
3.2
5g6sC-3kvnX:
2.9		 5g6sB-3kvnX:
20.50
5g6sC-3kvnX:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 MET A 196
GLY A 311
LEU A 223
MET A 220
PHE A 216
 None
 1.21A 5g6sB-3o57A:
undetectable
5g6sC-3o57A:
undetectable		 5g6sB-3o57A:
22.73
5g6sC-3o57A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 MET A 196
GLY A 311
LEU A 223
MET A 220
TYR A 219
 None
 0.90A 5g6sB-3o57A:
undetectable
5g6sC-3o57A:
undetectable		 5g6sB-3o57A:
22.73
5g6sC-3o57A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		5 MET A 122
GLY A 237
VAL A 169
LEU A 149
TYR A 145
 MET  A 122 ( 0.0A)
GLY  A 237 ( 0.0A)
VAL  A 169 ( 0.6A)
LEU  A 149 ( 0.6A)
TYR  A 145 ( 1.3A)
 1.25A 5g6sB-3sl5A:
undetectable
5g6sC-3sl5A:
undetectable		 5g6sB-3sl5A:
22.85
5g6sC-3sl5A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		5 MET A 122
SER A 197
GLY A 237
VAL A 169
LEU A 149
 MET  A 122 ( 0.0A)
SER  A 197 ( 0.0A)
GLY  A 237 ( 0.0A)
VAL  A 169 ( 0.6A)
LEU  A 149 ( 0.6A)
 1.49A 5g6sB-3sl5A:
undetectable
5g6sC-3sl5A:
undetectable		 5g6sB-3sl5A:
22.85
5g6sC-3sl5A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tij NUPC FAMILY PROTEIN

(Vibrio cholerae) 		PF01773
(Nucleos_tra2_N)
PF07662
(Nucleos_tra2_C)
PF07670
(Gate) 		5 MET A 266
SER A 337
MET A 195
GLY A 191
VAL A 334
 None
 1.11A 5g6sB-3tijA:
undetectable
5g6sC-3tijA:
undetectable		 5g6sB-3tijA:
24.01
5g6sC-3tijA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs6 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		PF00496
(SBP_bac_5) 		5 TYR A 228
SER A 546
GLY A 533
VAL A 258
LEU A 551
 None
 1.23A 5g6sB-3zs6A:
undetectable
5g6sC-3zs6A:
undetectable		 5g6sB-3zs6A:
22.00
5g6sC-3zs6A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw7 GH86A
BETA-PORPHYRANASE

(Bacteroides
plebeius) 		no annotation 5 GLN A 121
GLY A 123
LEU A 172
MET A 169
PHE A 162
 None
 1.26A 5g6sB-4aw7A:
undetectable
5g6sC-4aw7A:
undetectable		 5g6sB-4aw7A:
21.29
5g6sC-4aw7A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		5 TYR A 130
SER A 121
MET A  99
VAL A 224
LEU A 232
 None
 1.44A 5g6sB-4jypA:
undetectable
5g6sC-4jypA:
undetectable		 5g6sB-4jypA:
23.92
5g6sC-4jypA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA

(Artemisia
spiciformis) 		PF00348
(polyprenyl_synt) 		5 GLY A 212
VAL A  59
LEU A 209
TYR A 146
PHE A 141
 None
 1.37A 5g6sB-4kk2A:
0.6
5g6sC-4kk2A:
undetectable		 5g6sB-4kk2A:
21.04
5g6sC-4kk2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9g 2,4'-DIHYDROXYACETOP
HENONE DIOXYGENASE

(Alcaligenes sp.) 		PF07883
(Cupin_2) 		5 MET A 156
TYR A 153
SER A  49
VAL A  41
PHE A 148
 None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.5A)
None
GOL  A 403 ( 4.8A)
 1.41A 5g6sB-4p9gA:
undetectable
5g6sC-4p9gA:
undetectable		 5g6sB-4p9gA:
22.67
5g6sC-4p9gA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 MET A 368
GLY A 483
LEU A 395
MET A 392
PHE A 388
 None
 1.20A 5g6sB-4wziA:
undetectable
5g6sC-4wziA:
undetectable		 5g6sB-4wziA:
19.85
5g6sC-4wziA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 MET A 368
GLY A 483
LEU A 395
MET A 392
TYR A 391
 None
 0.93A 5g6sB-4wziA:
undetectable
5g6sC-4wziA:
undetectable		 5g6sB-4wziA:
19.85
5g6sC-4wziA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahv ANTH DOMAIN OF
ENDOCYTIC ADAPTOR
SLA2

(Saccharomyces
cerevisiae) 		PF07651
(ANTH) 		5 MET F 204
SER F 143
GLY F 217
LEU F 221
MET F 208
 None
 1.20A 5g6sB-5ahvF:
undetectable
5g6sC-5ahvF:
undetectable		 5g6sB-5ahvF:
22.40
5g6sC-5ahvF:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		5 TRP A  22
SER A  74
MET A  78
GLY A  30
LEU A  26
 None
 1.39A 5g6sB-5ej1A:
5.0
5g6sC-5ej1A:
4.8		 5g6sB-5ej1A:
16.13
5g6sC-5ej1A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es6 LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00551
(Formyl_trans_N) 		5 MET A 492
TYR A 478
LEU A 400
TYR A 375
PHE A 379
 None
 1.43A 5g6sB-5es6A:
2.1
5g6sC-5es6A:
2.4		 5g6sB-5es6A:
19.73
5g6sC-5es6A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00551
(Formyl_trans_N)
PF13193
(AMP-binding_C) 		5 MET A 492
TYR A 478
LEU A 400
TYR A 375
PHE A 379
 None
 1.38A 5g6sB-5es9A:
undetectable
5g6sC-5es9A:
2.6		 5g6sB-5es9A:
18.29
5g6sC-5es9A:
18.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g6r IMINE REDUCTASE

(Aspergillus
oryzae) 		PF03446
(NAD_binding_2) 		5 VAL A 121
LEU A 173
MET A 176
TYR A 177
PHE A 180
 NDP  A1000 ( 4.7A)
None
None
None
None
 0.59A 5g6sB-5g6rA:
37.8
5g6sC-5g6rA:
37.9		 5g6sB-5g6rA:
100.00
5g6sC-5g6rA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hws 2-DEHYDROPANTOATE
2-REDUCTASE

(Thermococcus
kodakarensis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 MET A   1
GLY A 143
VAL A 159
LEU A  96
PHE A 152
 None
 1.39A 5g6sB-5hwsA:
15.1
5g6sC-5hwsA:
15.0		 5g6sB-5hwsA:
26.14
5g6sC-5hwsA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j90 RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12741
(SusD-like) 		5 MET A 145
GLN A  70
GLY A 105
VAL A 115
MET A 148
 None
 1.40A 5g6sB-5j90A:
undetectable
5g6sC-5j90A:
undetectable		 5g6sB-5j90A:
20.08
5g6sC-5j90A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		no annotation 5 MET C 492
TYR C 478
LEU C 400
TYR C 375
PHE C 379
 None
 1.44A 5g6sB-5jnfC:
2.0
5g6sC-5jnfC:
2.8		 5g6sB-5jnfC:
21.53
5g6sC-5jnfC:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF01821
(ANATO)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 TYR B1053
SER B1096
GLN B1090
GLY B1152
LEU B1083
 None
 1.38A 5g6sB-5jpnB:
undetectable
5g6sC-5jpnB:
undetectable		 5g6sB-5jpnB:
18.55
5g6sC-5jpnB:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksd ATPASE 2, PLASMA
MEMBRANE-TYPE

(Arabidopsis
thaliana) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		5 TYR A 831
SER A 778
GLY A 784
VAL A 771
LEU A 787
 None
 1.16A 5g6sB-5ksdA:
2.4
5g6sC-5ksdA:
2.5		 5g6sB-5ksdA:
17.93
5g6sC-5ksdA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m58 C-METHYLTRANSFERASE
COUO

(Streptomyces
rishiriensis) 		PF13649
(Methyltransf_25) 		5 TYR A 191
SER A 146
VAL A 221
LEU A 143
PHE A 129
 None
 1.15A 5g6sB-5m58A:
4.2
5g6sC-5m58A:
4.1		 5g6sB-5m58A:
21.68
5g6sC-5m58A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE

(Streptomyces
niveus) 		PF13649
(Methyltransf_25) 		5 TYR A 191
SER A 146
VAL A 221
LEU A 143
PHE A 129
 None
 1.15A 5g6sB-5mgzA:
4.1
5g6sC-5mgzA:
4.0		 5g6sB-5mgzA:
22.73
5g6sC-5mgzA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5min QUINOPROTEIN GLUCOSE
DEHYDROGENASE B

(Acinetobacter
calcoaceticus) 		no annotation 5 TYR A 420
SER A 413
VAL A 418
LEU A 372
TYR A 355
 None
 1.29A 5g6sB-5minA:
undetectable
5g6sC-5minA:
undetectable		 5g6sB-5minA:
19.02
5g6sC-5minA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5l ADENYLATE CYCLASE

(Mycobacterium
intracellulare) 		no annotation 5 GLY A 299
VAL A 341
LEU A 276
TYR A 280
PHE A 283
 ONM  A 501 (-3.3A)
None
None
None
None
 1.31A 5g6sB-5o5lA:
undetectable
5g6sC-5o5lA:
undetectable		 5g6sB-5o5lA:
23.08
5g6sC-5o5lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 5 MET A 368
GLY A 483
LEU A 395
MET A 392
PHE A 388
 None
 1.24A 5g6sB-5ohjA:
undetectable
5g6sC-5ohjA:
undetectable		 5g6sB-5ohjA:
12.54
5g6sC-5ohjA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 5 MET A 368
GLY A 483
LEU A 395
MET A 392
TYR A 391
 None
 0.94A 5g6sB-5ohjA:
undetectable
5g6sC-5ohjA:
undetectable		 5g6sB-5ohjA:
12.54
5g6sC-5ohjA:
12.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ojl IMINE REDUCTASE

(Aspergillus
terreus) 		no annotation 5 TRP A 215
MET A 219
TYR A 222
SER A 240
GLN A 245
 None
 1.06A 5g6sB-5ojlA:
31.6
5g6sC-5ojlA:
31.7		 5g6sB-5ojlA:
50.57
5g6sC-5ojlA:
50.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uao TRYPTOPHANE-5-HALOGE
NASE

(Microbispora
sp. ATCC
PTA-5024) 		PF04820
(Trp_halogenase) 		5 MET A 176
TYR A 174
LEU A 185
TYR A 184
PHE A  93
 None
 1.34A 5g6sB-5uaoA:
5.1
5g6sC-5uaoA:
5.1		 5g6sB-5uaoA:
19.96
5g6sC-5uaoA:
19.96