SIMILAR PATTERNS OF AMINO ACIDS FOR 5G5H_C_ACTC1743

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 LYS A 349
ASP A 370
PHE A 343
PRO A 380
 None
 1.41A 5g5hA-1w9xA:
0.0
5g5hC-1w9xA:
0.0		 5g5hA-1w9xA:
19.18
5g5hC-1w9xA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 LYS A 349
ASP A 370
PHE A 343
PRO A 380
 None
 1.38A 5g5hA-2d3lA:
0.0
5g5hC-2d3lA:
0.0		 5g5hA-2d3lA:
19.65
5g5hC-2d3lA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 LYS A 349
ASP A 370
PHE A 343
PRO A 380
 None
 1.41A 5g5hA-2dieA:
0.0
5g5hC-2dieA:
0.0		 5g5hA-2dieA:
18.78
5g5hC-2dieA:
20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF00111
(Fer2)
PF01799
(Fer2_2)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 LYS A  97
ASP A 100
PHE C 120
MET C 269
PRO C 271
 None
None
None
IOD  A1227 ( 4.1A)
None
 0.14A 5g5hA-5g5gA:
31.9
5g5hC-5g5gA:
0.0		 5g5hA-5g5gA:
100.00
5g5hC-5g5gA:
16.44