SIMILAR PATTERNS OF AMINO ACIDS FOR 5G5H_C_ACTC1742

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ASP B 224
LYS B 227
THR B 231
ASP B 229
 None
 1.32A 5g5hC-1ffvB:
36.0		 5g5hC-1ffvB:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF02358
(Trehalose_PPase) 		4 ASP A 179
LYS A 197
THR A 182
ASP A 183
 MG  A 240 (-2.5A)
None
None
MG  A 240 ( 4.5A)
 1.39A 5g5hC-1u02A:
0.0		 5g5hC-1u02A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yew CAPSID PROTEIN

(Barmah Forest
virus) 		PF00944
(Peptidase_S3) 		4 ASP A 124
LYS A 125
TRP A 237
THR A 171
 None
 1.27A 5g5hC-2yewA:
0.0		 5g5hC-2yewA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjp PEROXIREDOXIN,
BACTERIOFERRITIN
COMIGRATORY PROTEIN
HOMOLOG (BCP-4)

(Sulfolobus
solfataricus) 		PF00578
(AhpC-TSA) 		4 ASP A  17
LYS A  19
THR A  89
ASP A  15
 None
 1.25A 5g5hC-3hjpA:
0.0		 5g5hC-3hjpA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuw NEUTRAL
ENDOPEPTIDASE

(Lactobacillus
rhamnosus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 ASP A 440
LYS A 443
THR A 447
ASP A 445
 None
 1.15A 5g5hC-4iuwA:
0.0		 5g5hC-4iuwA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Homo sapiens) 		PF04389
(Peptidase_M28) 		4 ASP A 248
TRP A 329
THR A 158
ASP A 159
 None
None
None
ZN  A 401 (-2.1A)
 1.47A 5g5hC-4yu9A:
0.0		 5g5hC-4yu9A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6k POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ASP A  45
LYS A  46
THR A  39
ASP A  43
 None
 1.43A 5g5hC-5e6kA:
0.0		 5g5hC-5e6kA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eny POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ASP A  45
LYS A  46
THR A  39
ASP A  43
 None
 1.33A 5g5hC-5enyA:
0.0		 5g5hC-5enyA:
22.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ASP C  93
LYS C  94
TRP C 215
THR C 218
ASP C 219
 None
 0.52A 5g5hC-5g5gC:
60.9		 5g5hC-5g5gC:
99.86