SIMILAR PATTERNS OF AMINO ACIDS FOR 5G5H_A_ACTA1229

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE

(Escherichia
coli) 		PF00115
(COX1) 		4 VAL A 127
GLU A 300
THR A 538
GLU A 540
 None
 1.09A 5g5hA-1fftA:
0.0		 5g5hA-1fftA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbv MAJOR OUTER MEMBRANE
PROTEIN PAN 1

(Neisseria
gonorrhoeae) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 VAL A  41
GLU A  83
THR A 120
GLU A  81
 None
 1.46A 5g5hA-1kbvA:
0.0		 5g5hA-1kbvA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jex REGULATORY PROTEIN
E2

(Deltapapillomavirus
4) 		PF00508
(PPV_E2_N) 		4 VAL A 188
GLU A 120
THR A 128
GLU A 118
 None
 1.47A 5g5hA-2jexA:
undetectable		 5g5hA-2jexA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		4 VAL A 199
GLU A 229
THR A 226
GLU A 228
 None
 1.43A 5g5hA-2tohA:
0.0		 5g5hA-2tohA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE

(Listeria
innocua) 		PF06838
(Met_gamma_lyase) 		4 VAL A  70
GLU A 211
THR A 213
GLU A 214
 None
None
None
PEG  A 427 ( 4.6A)
 1.41A 5g5hA-3fd0A:
0.0		 5g5hA-3fd0A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA

(Methylobacillus
flagellatus) 		PF08886
(GshA) 		4 VAL A 359
GLU A 334
THR A 332
GLU A 342
 None
None
None
GOL  A 444 (-3.2A)
 1.50A 5g5hA-3k1tA:
0.0		 5g5hA-3k1tA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 VAL A 141
GLU A 122
THR A 148
GLU A 143
 None
 1.45A 5g5hA-3s2uA:
0.0		 5g5hA-3s2uA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00180
(Iso_dh) 		4 VAL A  16
GLU A  14
THR A 344
GLU A  18
 None
 1.25A 5g5hA-4iwhA:
0.0		 5g5hA-4iwhA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1p L-ARABINOSE
ISOMERASE

(Geobacillus
kaustophilus) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		4 VAL A 189
GLU A 281
THR A 279
GLU A 307
 None
None
None
MN  A 501 (-2.7A)
 1.44A 5g5hA-4r1pA:
0.0		 5g5hA-4r1pA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5daj NALD

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		4 VAL A  28
GLU A 121
THR A 119
GLU A 117
 None
 1.46A 5g5hA-5dajA:
undetectable		 5g5hA-5dajA:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT

(Escherichia
coli) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		4 VAL A 186
GLU A 193
THR A 195
GLU A 198
 None
 0.67A 5g5hA-5g5gA:
31.9		 5g5hA-5g5gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN

(Homo sapiens) 		PF00400
(WD40) 		4 VAL A 338
GLU A 340
THR A 321
GLU A 301
 None
 1.48A 5g5hA-5tf2A:
undetectable		 5g5hA-5tf2A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		4 VAL A 932
GLU A1274
THR A1276
GLU A1206
 None
 1.18A 5g5hA-5x7sA:
undetectable		 5g5hA-5x7sA:
10.59