SIMILAR PATTERNS OF AMINO ACIDS FOR 5G5G_C_ACTC1740

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c07 PROTEIN (EPIDERMAL
GROWTH FACTOR
RECEPTOR PATHWAY
SUBSTRATE 15)

(Homo sapiens) 		PF12763
(EF-hand_4) 		4 VAL A  40
GLU A  39
GLY A  37
LEU A  69
 None
CA  A 110 (-2.4A)
None
None
 1.33A 5g5gC-1c07A:
undetectable		 5g5gC-1c07A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cq3 VIRAL CHEMOKINE
INHIBITOR

(Cowpox virus) 		PF02250
(Orthopox_35kD) 		4 VAL A  94
GLU A  87
GLY A  68
LEU A  70
 None
 1.02A 5g5gC-1cq3A:
0.0		 5g5gC-1cq3A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg3 DYSTROPHIN

(Homo sapiens) 		PF00397
(WW)
PF09068
(EF-hand_2)
PF09069
(EF-hand_3) 		4 VAL A 263
GLU A 260
GLY A 235
LEU A 238
 None
 1.26A 5g5gC-1eg3A:
0.0		 5g5gC-1eg3A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 VAL A 393
GLU A 392
GLY A 362
LEU A 396
 None
 1.34A 5g5gC-1ethA:
0.0		 5g5gC-1ethA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 VAL A 305
GLU A 306
GLY A 366
LEU A 365
 None
 1.16A 5g5gC-1fpqA:
0.0		 5g5gC-1fpqA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 VAL A 496
GLU A 493
GLY A 145
LEU A 142
 None
 1.14A 5g5gC-1g8kA:
0.0		 5g5gC-1g8kA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hup MANNOSE-BINDING
PROTEIN

(Homo sapiens) 		PF00059
(Lectin_C) 		4 VAL A 142
GLU A 225
GLY A 165
LEU A 178
 None
 1.23A 5g5gC-1hupA:
0.0		 5g5gC-1hupA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mcw IMMUNOGLOBULIN WEIR
(LIGHT CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL W 107
GLU W  85
GLY W  12
LEU W  80
 None
 1.26A 5g5gC-1mcwW:
0.0		 5g5gC-1mcwW:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mty METHANE
MONOOXYGENASE
HYDROXYLASE
METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus;
Methylococcus
capsulatus) 		PF02332
(Phenol_Hydrox)
PF02332
(Phenol_Hydrox) 		4 VAL D  23
GLU D  27
GLY B 198
LEU B 195
 None
 1.39A 5g5gC-1mtyD:
0.0		 5g5gC-1mtyD:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgv TROPOMODULIN TMD-1

(Caenorhabditis
elegans) 		no annotation 4 VAL A 340
GLU A 308
GLY A 337
LEU A 336
 None
 1.08A 5g5gC-1pgvA:
0.0		 5g5gC-1pgvA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl8 HUMAN SORBITOL
DEHYDROGENASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A  41
GLU A  70
GLY A  68
LEU A 128
 None
ZN  A 402 (-3.2A)
None
None
 1.20A 5g5gC-1pl8A:
undetectable		 5g5gC-1pl8A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qp8 FORMATE
DEHYDROGENASE

(Pyrobaculum
aerophilum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 VAL A  32
GLU A   2
GLY A  30
LEU A  29
 None
 1.14A 5g5gC-1qp8A:
undetectable		 5g5gC-1qp8A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3i 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE

(Rattus
norvegicus) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 VAL A  27
GLU A  25
GLY A  77
LEU A  76
 None
 1.29A 5g5gC-1s3iA:
undetectable		 5g5gC-1s3iA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0z NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 VAL A 238
GLU A 236
GLY A 289
LEU A  93
 None
 1.07A 5g5gC-1v0zA:
undetectable		 5g5gC-1v0zA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v30 HYPOTHETICAL UPF0131
PROTEIN PH0828

(Pyrococcus
horikoshii) 		PF06094
(GGACT) 		4 VAL A  12
GLU A  60
GLY A  14
LEU A  16
 NHE  A2854 (-3.4A)
None
NHE  A2854 (-2.9A)
NHE  A2854 (-3.3A)
 1.32A 5g5gC-1v30A:
undetectable		 5g5gC-1v30A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb3 THREONINE SYNTHASE

(Escherichia
coli) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 VAL A 242
GLU A 369
GLY A 371
LEU A 361
 None
 1.40A 5g5gC-1vb3A:
undetectable		 5g5gC-1vb3A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz8 ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		4 VAL A 146
GLU A 239
GLY A 242
LEU A 248
 None
MPD  A3003 (-3.2A)
None
None
 1.30A 5g5gC-1wz8A:
undetectable		 5g5gC-1wz8A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 VAL A 554
GLU A 553
GLY A 550
LEU A 745
 None
 1.32A 5g5gC-1x9nA:
undetectable		 5g5gC-1x9nA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 VAL A 233
GLU A 231
GLY A 284
LEU A  88
 None
 1.12A 5g5gC-1xogA:
undetectable		 5g5gC-1xogA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima) 		PF02065
(Melibiase) 		4 VAL A 473
GLU A 444
GLY A 470
LEU A 431
 None
 1.34A 5g5gC-1zy9A:
0.2		 5g5gC-1zy9A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1d SOXA

(Paracoccus
denitrificans) 		no annotation 4 VAL A 101
GLU A 104
GLY A 149
LEU A 150
 None
 1.10A 5g5gC-2c1dA:
undetectable		 5g5gC-2c1dA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfz SDS HYDROLASE SDSA1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 VAL A 443
GLU A 479
GLY A 448
LEU A 452
 None
 1.25A 5g5gC-2cfzA:
undetectable		 5g5gC-2cfzA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de0 ALPHA-(1,6)-FUCOSYLT
RANSFERASE

(Homo sapiens) 		PF14604
(SH3_9) 		4 VAL X 474
GLU X 477
GLY X 221
LEU X 224
 None
 1.37A 5g5gC-2de0X:
undetectable		 5g5gC-2de0X:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eel CELL DEATH ACTIVATOR
CIDE-A

(Homo sapiens) 		PF02017
(CIDE-N) 		4 VAL A  48
GLU A  78
GLY A  46
LEU A  38
 None
 1.19A 5g5gC-2eelA:
undetectable		 5g5gC-2eelA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fin RABBITPOX ENCODED CC
CHEMOKINE INHIBITOR

(Vaccinia virus) 		PF02250
(Orthopox_35kD) 		4 VAL A 112
GLU A 105
GLY A  86
LEU A  88
 None
 1.25A 5g5gC-2finA:
undetectable		 5g5gC-2finA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1

(Homo sapiens) 		PF00171
(Aldedh) 		4 VAL A 120
GLU A 119
GLY A 102
LEU A 101
 None
 0.86A 5g5gC-2j6lA:
undetectable		 5g5gC-2j6lA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg7 ANTIQUITIN

(Acanthopagrus
schlegelii) 		PF00171
(Aldedh) 		4 VAL A 118
GLU A 117
GLY A 100
LEU A  99
 None
 0.89A 5g5gC-2jg7A:
undetectable		 5g5gC-2jg7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2npu FKBP12-RAPAMYCIN
COMPLEX-ASSOCIATED
PROTEIN

(Homo sapiens) 		PF08771
(FRB_dom) 		4 VAL A2050
GLU A2033
GLY A2030
LEU A2054
 None
 1.34A 5g5gC-2npuA:
undetectable		 5g5gC-2npuA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkb SERINE
DEHYDRATASE-LIKE

(Homo sapiens) 		PF00291
(PALP) 		4 VAL A 173
GLU A 200
GLY A 176
LEU A 179
 PLP  A 400 ( 4.1A)
K  A 401 (-3.7A)
PLP  A 400 (-2.9A)
None
 1.34A 5g5gC-2rkbA:
undetectable		 5g5gC-2rkbA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE

(Thermotoga
maritima) 		PF00483
(NTP_transferase) 		4 VAL A  56
GLU A  80
GLY A  93
LEU A   5
 GTP  A 601 (-4.0A)
GTP  A 601 (-2.9A)
None
None
 1.29A 5g5gC-2x60A:
undetectable		 5g5gC-2x60A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xs6 PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA

(Homo sapiens) 		PF00620
(RhoGAP) 		4 VAL A 232
GLU A 136
GLY A 230
LEU A 229
 None
 1.37A 5g5gC-2xs6A:
undetectable		 5g5gC-2xs6A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 294
GLU A 116
GLY A 275
LEU A 276
 None
 1.38A 5g5gC-2yquA:
undetectable		 5g5gC-2yquA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0u RESPONSE REGULATOR

(Thermotoga
maritima) 		PF00072
(Response_reg) 		4 VAL A  63
GLU A  62
GLY A  34
LEU A  38
 None
 1.15A 5g5gC-3a0uA:
undetectable		 5g5gC-3a0uA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE
SLIDING CLAMP

(Pyrococcus
furiosus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 VAL B 140
GLU B 139
GLY B 185
LEU B 179
 None
 1.25A 5g5gC-3a2fB:
undetectable		 5g5gC-3a2fB:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqt UNCHARACTERIZED
PROTEIN

(Listeria
monocytogenes) 		PF04994
(TfoX_C) 		4 VAL A  62
GLU A  59
GLY A  35
LEU A  31
 None
 1.32A 5g5gC-3bqtA:
undetectable		 5g5gC-3bqtA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjs RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 4 VAL A  35
GLU A  30
GLY A   8
LEU A  13
 None
 1.36A 5g5gC-3cjsA:
undetectable		 5g5gC-3cjsA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjt RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF06325
(PrmA) 		4 VAL A  35
GLU A  30
GLY A   8
LEU A  13
 None
 1.36A 5g5gC-3cjtA:
undetectable		 5g5gC-3cjtA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnf 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE

(Aquifex
aeolicus) 		PF02401
(LYTB) 		4 VAL A 127
GLU A 126
GLY A 120
LEU A 118
 None
 1.13A 5g5gC-3dnfA:
undetectable		 5g5gC-3dnfA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3geh TRNA MODIFICATION
GTPASE MNME

(Nostoc sp. PCC
7120) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		4 VAL A 443
GLU A 437
GLY A 440
LEU A 129
 None
 1.18A 5g5gC-3gehA:
undetectable		 5g5gC-3gehA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ing HOMOSERINE
DEHYDROGENASE

(Thermoplasma
acidophilum) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 VAL A 251
GLU A 253
GLY A 168
LEU A 276
 None
 1.36A 5g5gC-3ingA:
undetectable		 5g5gC-3ingA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsa HOMOSERINE
DEHYDROGENASE

(Thermoplasma
volcanium) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 VAL A 255
GLU A 257
GLY A 170
LEU A 280
 None
 1.33A 5g5gC-3jsaA:
undetectable		 5g5gC-3jsaA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcn ADENYLATE CYCLASE
HOMOLOG

(Rhodopirellula
baltica) 		PF00072
(Response_reg) 		4 VAL A  68
GLU A  67
GLY A  38
LEU A  42
 None
 1.14A 5g5gC-3kcnA:
undetectable		 5g5gC-3kcnA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv0 HET-C2

(Podospora
anserina) 		PF08718
(GLTP) 		4 VAL A 179
GLU A 182
GLY A 173
LEU A 172
 MLY  A 178 ( 3.4A)
None
MLY  A 171 ( 4.6A)
MLY  A 171 ( 4.1A)
 1.31A 5g5gC-3kv0A:
undetectable		 5g5gC-3kv0A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcv SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM

(Micromonospora
zionensis) 		PF07091
(FmrO) 		4 VAL B 215
GLU B 214
GLY B 212
LEU B 204
 None
 1.23A 5g5gC-3lcvB:
undetectable		 5g5gC-3lcvB:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n40 P62 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		PF00943
(Alpha_E2_glycop)
PF01563
(Alpha_E3_glycop) 		4 VAL P 332
GLU P 203
GLY P 201
LEU P 215
 None
 1.39A 5g5gC-3n40P:
undetectable		 5g5gC-3n40P:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owc PROBABLE
ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		4 VAL A 169
GLU A 151
GLY A 153
LEU A 154
 None
 1.14A 5g5gC-3owcA:
1.1		 5g5gC-3owcA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 VAL A 134
GLU A 136
GLY A 100
LEU A 101
 None
 1.25A 5g5gC-3pocA:
1.1		 5g5gC-3pocA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm3 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Campylobacter
jejuni) 		PF01116
(F_bP_aldolase) 		4 VAL A  78
GLU A  77
GLY A 116
LEU A 117
 None
 0.94A 5g5gC-3qm3A:
undetectable		 5g5gC-3qm3A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID

(Mammuthus
primigenius) 		PF00042
(Globin) 		4 VAL B 134
GLU B 131
GLY B 107
LEU B 110
 None
 1.22A 5g5gC-3vreB:
undetectable		 5g5gC-3vreB:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 VAL L  76
GLU L 108
GLY L 103
LEU L  41
 None
 1.33A 5g5gC-3wxrL:
undetectable		 5g5gC-3wxrL:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8x POSSIBLE
MARR-TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF12802
(MarR_2) 		4 VAL A 126
GLU A 125
GLY A 123
LEU A 102
 None
 1.09A 5g5gC-4b8xA:
undetectable		 5g5gC-4b8xA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL

(Homo sapiens) 		PF07992
(Pyr_redox_2)
PF14721
(AIF_C) 		4 VAL A 277
GLU A 276
GLY A 373
LEU A 379
 None
 1.10A 5g5gC-4bv6A:
undetectable		 5g5gC-4bv6A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A

(Aspergillus
tubingensis) 		PF00295
(Glyco_hydro_28) 		4 VAL A  92
GLU A  93
GLY A 129
LEU A 167
 None
 1.11A 5g5gC-4c2lA:
undetectable		 5g5gC-4c2lA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus) 		PF03486
(HI0933_like) 		4 VAL A 323
GLU A 250
GLY A 325
LEU A 197
 None
 1.21A 5g5gC-4cnkA:
undetectable		 5g5gC-4cnkA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw7 PUTATIVE ADENYLATE
KINASE

(Pyrococcus
abyssi) 		PF13238
(AAA_18) 		4 VAL A  11
GLU A 114
GLY A   7
LEU A  86
 ATP  A1001 (-4.4A)
None
None
None
 1.13A 5g5gC-4cw7A:
undetectable		 5g5gC-4cw7A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG

(Sphingomonas
paucimobilis) 		PF13417
(GST_N_3)
PF16865
(GST_C_5) 		4 VAL A 131
GLU A 134
GLY A 112
LEU A 171
 None
 1.36A 5g5gC-4g10A:
undetectable		 5g5gC-4g10A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE

(Escherichia
coli) 		PF02401
(LYTB) 		4 VAL A 127
GLU A 126
GLY A 120
LEU A 118
 None
 1.15A 5g5gC-4h4cA:
undetectable		 5g5gC-4h4cA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjc ENVELOPE
GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		PF07245
(Phlebovirus_G2) 		4 VAL A1093
GLU A1092
GLY A1112
LEU A1114
 None
 1.39A 5g5gC-4hjcA:
undetectable		 5g5gC-4hjcA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixu ARGINASE-2,
MITOCHONDRIAL

(Homo sapiens) 		PF00491
(Arginase) 		4 VAL A 295
GLU A 296
GLY A 118
LEU A 122
 None
38I  A 406 (-3.8A)
None
None
 1.34A 5g5gC-4ixuA:
undetectable		 5g5gC-4ixuA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Neisseria
meningitidis) 		PF13561
(adh_short_C2) 		4 VAL A 151
GLU A 168
GLY A 149
LEU A 148
 None
 1.28A 5g5gC-4m87A:
undetectable		 5g5gC-4m87A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7b LYTB

(Plasmodium
falciparum) 		PF02401
(LYTB) 		4 VAL A 129
GLU A 128
GLY A 122
LEU A 120
 None
 1.07A 5g5gC-4n7bA:
undetectable		 5g5gC-4n7bA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis) 		PF04909
(Amidohydro_2) 		4 VAL A 131
GLU A 127
GLY A 114
LEU A 137
 None
 1.15A 5g5gC-4ng3A:
undetectable		 5g5gC-4ng3A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nic DNA-BINDING
TRANSCRIPTIONAL
REGULATOR RSTA

(Klebsiella
pneumoniae) 		PF00072
(Response_reg) 		4 VAL A   7
GLU A  31
GLY A  34
LEU A  55
 None
 1.20A 5g5gC-4nicA:
undetectable		 5g5gC-4nicA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 VAL A 395
GLU A 389
GLY A 387
LEU A1237
 None
 1.25A 5g5gC-4o9xA:
undetectable		 5g5gC-4o9xA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN

(Fusobacterium
nucleatum) 		PF03480
(DctP) 		4 VAL A 222
GLU A 151
GLY A 205
LEU A 198
 None
 1.02A 5g5gC-4pfbA:
undetectable		 5g5gC-4pfbA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00171
(Aldedh) 		4 VAL A 118
GLU A 117
GLY A 100
LEU A  99
 None
 0.89A 5g5gC-4pxnA:
undetectable		 5g5gC-4pxnA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qv9 PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 VAL K  76
GLU K 108
GLY K 103
LEU K  41
 None
 1.22A 5g5gC-4qv9K:
undetectable		 5g5gC-4qv9K:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN

(Lactococcus
phage 1358) 		no annotation 4 VAL A 246
GLU A 248
GLY A 339
LEU A 295
 None
 1.08A 5g5gC-4rggA:
undetectable		 5g5gC-4rggA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 VAL B 318
GLU B 322
GLY B 334
LEU B 335
 None
 0.93A 5g5gC-4um8B:
undetectable		 5g5gC-4um8B:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04101
(Glyco_tran_28_C)
PF06925
(MGDG_synth) 		4 VAL A 331
GLU A 418
GLY A 422
LEU A 337
 None
 1.09A 5g5gC-4wyiA:
undetectable		 5g5gC-4wyiA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66

(Homo sapiens) 		PF08007
(Cupin_4) 		4 VAL A 559
GLU A 560
GLY A 618
LEU A 619
 None
 0.72A 5g5gC-4y4rA:
undetectable		 5g5gC-4y4rA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zbg ACETYLTRANSFERASE

(Brucella
abortus) 		PF13527
(Acetyltransf_9) 		4 VAL A  17
GLU A  13
GLY A  59
LEU A  84
 None
 1.14A 5g5gC-4zbgA:
1.2		 5g5gC-4zbgA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED

(Bacteroides
thetaiotaomicron) 		PF04041
(Glyco_hydro_130) 		4 VAL B 123
GLU B 119
GLY B 106
LEU B  87
 None
 1.12A 5g5gC-5a7vB:
undetectable		 5g5gC-5a7vB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase) 		4 VAL A 288
GLU A 286
GLY A 227
LEU A 318
 ZN  A 343 ( 4.8A)
None
None
None
 1.40A 5g5gC-5a89A:
undetectable		 5g5gC-5a89A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brj TWO COMPONENT
RESPONSE REGULATOR

(Agrobacterium
tumefaciens) 		PF00072
(Response_reg) 		4 VAL A  76
GLU A  75
GLY A  38
LEU A  42
 None
 0.98A 5g5gC-5brjA:
undetectable		 5g5gC-5brjA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btb AFR263CP

(Eremothecium
gossypii) 		PF08652
(RAI1) 		4 VAL A 216
GLU A 215
GLY A 218
LEU A  43
 None
 1.34A 5g5gC-5btbA:
0.2		 5g5gC-5btbA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3u L-SERINE
AMMONIA-LYASE

(Rhizomucor
miehei) 		PF00291
(PALP) 		4 VAL A 179
GLU A 206
GLY A 182
LEU A 185
 PLP  A 401 ( 4.1A)
None
PLP  A 401 (-3.4A)
None
 1.31A 5g5gC-5c3uA:
undetectable		 5g5gC-5c3uA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 VAL A 444
GLU A 451
GLY A 535
LEU A 536
 None
CA  A2002 (-3.0A)
None
None
 1.01A 5g5gC-5e6sA:
undetectable		 5g5gC-5e6sA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		4 VAL A 314
GLU A 293
GLY A 415
LEU A 418
 None
 1.32A 5g5gC-5e78A:
undetectable		 5g5gC-5e78A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		4 VAL A 297
GLU A 296
GLY A 294
LEU A 292
 None
 1.11A 5g5gC-5e7pA:
undetectable		 5g5gC-5e7pA:
26.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewq AMIDASE

(Bacillus
anthracis) 		PF01425
(Amidase) 		4 VAL A 293
GLU A 525
GLY A 521
LEU A 490
 None
 1.27A 5g5gC-5ewqA:
undetectable		 5g5gC-5ewqA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsh CSM6

(Thermus
thermophilus) 		PF09670
(Cas_Cas02710) 		4 VAL A 280
GLU A 284
GLY A 252
LEU A 256
 None
 1.00A 5g5gC-5fshA:
undetectable		 5g5gC-5fshA:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 VAL C 320
GLU C 324
GLY C 335
LEU C 336
 None
ACT  C1740 (-3.1A)
ACT  C1740 ( 3.9A)
ACT  C1740 ( 4.5A)
 0.00A 5g5gC-5g5gC:
64.2		 5g5gC-5g5gC:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idq SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Burkholderia
vietnamiensis) 		PF00106
(adh_short) 		4 VAL A 200
GLU A 203
GLY A 220
LEU A 216
 None
 1.06A 5g5gC-5idqA:
undetectable		 5g5gC-5idqA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jn0 CRK-II SH2 DOMAIN

(Homo sapiens) 		PF00017
(SH2) 		4 VAL A  51
GLU A  53
GLY A  33
LEU A  97
 None
 0.90A 5g5gC-5jn0A:
undetectable		 5g5gC-5jn0A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzv ADENYLATE KINASE
ISOENZYME 6

(Homo sapiens) 		PF13238
(AAA_18) 		4 VAL A  14
GLU A 123
GLY A  10
LEU A  95
 ADP  A 201 (-4.2A)
None
None
None
 1.21A 5g5gC-5jzvA:
undetectable		 5g5gC-5jzvA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3z POLYKETIDE
KETOREDUCTASE SIMC7

(Streptomyces
antibioticus) 		PF13460
(NAD_binding_10) 		4 VAL A  46
GLU A  44
GLY A  29
LEU A   4
 None
 1.17A 5g5gC-5l3zA:
undetectable		 5g5gC-5l3zA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 VAL A 109
GLU A 111
GLY A 100
LEU A 101
 None
None
FAD  A 501 ( 3.8A)
None
 1.19A 5g5gC-5l6fA:
undetectable		 5g5gC-5l6fA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcn UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF12146
(Hydrolase_4) 		4 VAL A 154
GLU A 121
GLY A 151
LEU A  72
 None
 1.22A 5g5gC-5lcnA:
0.4		 5g5gC-5lcnA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		no annotation 4 VAL A 183
GLU A 182
GLY A 180
LEU A 175
 None
 1.14A 5g5gC-5lj9A:
undetectable		 5g5gC-5lj9A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nem INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 VAL B 315
GLU B 319
GLY B 331
LEU B 332
 None
 0.83A 5g5gC-5nemB:
undetectable		 5g5gC-5nemB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nge UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		no annotation 4 VAL A 263
GLU A 266
GLY A 275
LEU A 216
 None
 1.31A 5g5gC-5ngeA:
undetectable		 5g5gC-5ngeA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uib OXIDOREDUCTASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF01408
(GFO_IDH_MocA) 		4 VAL A 111
GLU A 115
GLY A 316
LEU A 320
 None
 0.87A 5g5gC-5uibA:
undetectable		 5g5gC-5uibA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upr TRIOSEPHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF00121
(TIM) 		4 VAL A 230
GLU A 225
GLY A 211
LEU A 210
 None
 1.06A 5g5gC-5uprA:
0.1		 5g5gC-5uprA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 VAL A 807
GLU A 783
GLY A 824
LEU A 728
 None
 1.39A 5g5gC-5ux5A:
undetectable		 5g5gC-5ux5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvw UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Pseudomonas
aeruginosa) 		PF01225
(Mur_ligase)
PF08245
(Mur_ligase_M) 		4 VAL A 147
GLU A 170
GLY A 150
LEU A 108
 None
 1.35A 5g5gC-5vvwA:
undetectable		 5g5gC-5vvwA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yak -

(-) 		no annotation 4 VAL A 111
GLU A 109
GLY A 266
LEU A 233
 None
 0.87A 5g5gC-5yakA:
undetectable		 5g5gC-5yakA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4j NUCLEOPORIN GLE1

(Homo sapiens) 		no annotation 4 VAL B 492
GLU B 491
GLY B 488
LEU B 576
 None
 1.24A 5g5gC-6b4jB:
undetectable		 5g5gC-6b4jB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c62 BIURET HYDROLASE

(Pseudomonas sp.
ADP) 		no annotation 4 VAL A 289
GLU A 287
GLY A 258
LEU A 367
 None
 1.32A 5g5gC-6c62A:
undetectable		 5g5gC-6c62A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6req PROTEIN
(METHYLMALONYL-COA
MUTASE)

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase) 		4 VAL B 581
GLU B 580
GLY B 578
LEU B 518
 None
 1.13A 5g5gC-6reqB:
0.0		 5g5gC-6reqB:
23.51