SIMILAR PATTERNS OF AMINO ACIDS FOR 5G5G_B_ACTB1321

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bu3 CALCIUM-BINDING
PROTEIN

(Merluccius
bilinearis) 		PF13499
(EF-hand_7) 		3 THR A  78
ASP A  79
ALA A  80
 None
 0.00A 5g5gB-1bu3A:
undetectable		 5g5gB-1bu3A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		3 THR A 354
ASP A 355
ALA A 356
 None
 0.09A 5g5gB-1crlA:
0.0		 5g5gB-1crlA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		3 THR 1 103
ASP 1 104
ALA 1 105
 None
 0.06A 5g5gB-1gt91:
0.0		 5g5gB-1gt91:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		3 THR A 248
ASP A 249
ALA A 250
 None
 0.06A 5g5gB-1guqA:
0.0		 5g5gB-1guqA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		3 THR A 354
ASP A 355
ALA A 356
 None
 0.00A 5g5gB-1gz7A:
0.0		 5g5gB-1gz7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Escherichia
coli) 		PF03740
(PdxJ) 		3 THR A 164
ASP A 165
ALA A 166
 None
 0.08A 5g5gB-1ixpA:
0.0		 5g5gB-1ixpA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdi L-RIBULOSE 5
PHOSPHATE
4-EPIMERASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		3 THR A 133
ASP A 134
ALA A 135
 None
 0.11A 5g5gB-1jdiA:
0.0		 5g5gB-1jdiA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knl ENDO-1,4-BETA-XYLANA
SE A

(Streptomyces
lividans) 		PF00652
(Ricin_B_lectin) 		3 THR A  46
ASP A  47
ALA A  48
 None
 0.00A 5g5gB-1knlA:
undetectable		 5g5gB-1knlA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ouu HEMOGLOBIN I

(Oncorhynchus
mykiss) 		PF00042
(Globin) 		3 THR B   4
ASP B   5
ALA B   6
 None
 0.05A 5g5gB-1ouuB:
undetectable		 5g5gB-1ouuB:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh4 CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 THR A 180
ASP A 181
ALA A 182
 None
 0.08A 5g5gB-1qh4A:
undetectable		 5g5gB-1qh4A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqb TRANSCARBOXYLASE 5S
SUBUNIT

(Propionibacterium
freudenreichii) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		3 THR A 466
ASP A 467
ALA A 468
 None
 0.04A 5g5gB-1rqbA:
0.0		 5g5gB-1rqbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spj KALLIKREIN 1

(Homo sapiens) 		PF00089
(Trypsin) 		3 THR A 115
ASP A 116
ALA A 117
 None
 0.00A 5g5gB-1spjA:
undetectable		 5g5gB-1spjA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tue REGULATORY PROTEIN
E2

(Alphapapillomavirus
7) 		PF00508
(PPV_E2_N) 		3 THR B 145
ASP B 146
ALA B 147
 None
 0.00A 5g5gB-1tueB:
undetectable		 5g5gB-1tueB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6u ENDO-1,4-BETA-D-XYLA
NASE

(Streptomyces
olivaceoviridis) 		PF00331
(Glyco_hydro_10)
PF00652
(Ricin_B_lectin) 		3 THR A 353
ASP A 354
ALA A 355
 None
 0.05A 5g5gB-1v6uA:
undetectable		 5g5gB-1v6uA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE

(Clostridium
acetobutylicum) 		PF04029
(2-ph_phosp) 		3 THR A 176
ASP A 177
ALA A 178
 None
 0.00A 5g5gB-1vr0A:
undetectable		 5g5gB-1vr0A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ynb HYPOTHETICAL PROTEIN
AF1432

(Archaeoglobus
fulgidus) 		PF13023
(HD_3) 		3 THR A 153
ASP A 154
ALA A 155
 None
 0.11A 5g5gB-1ynbA:
undetectable		 5g5gB-1ynbA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb7 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 THR A  81
ASP A  82
ALA A  83
 None
 0.10A 5g5gB-1zb7A:
undetectable		 5g5gB-1zb7A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csd TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		3 THR A 508
ASP A 509
ALA A 510
 None
 0.00A 5g5gB-2csdA:
undetectable		 5g5gB-2csdA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF00232
(Glyco_hydro_1) 		3 THR A 239
ASP A 240
ALA A 241
 None
 0.10A 5g5gB-2e3zA:
undetectable		 5g5gB-2e3zA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e80 CYTOCHROME C-552

(Wolinella
succinogenes) 		PF02335
(Cytochrom_C552) 		3 THR A 375
ASP A 376
ALA A 377
 None
 0.08A 5g5gB-2e80A:
undetectable		 5g5gB-2e80A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6u ORNITHINE
CARBAMOYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 THR A 274
ASP A 275
ALA A 276
 SO4  A 801 (-3.1A)
None
SO4  A 801 ( 3.7A)
 0.11A 5g5gB-2i6uA:
undetectable		 5g5gB-2i6uA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1n OUTER MEMBRANE
PROTEIN C

(Escherichia
coli) 		PF00267
(Porin_1) 		3 THR A 203
ASP A 204
ALA A 205
 None
 0.00A 5g5gB-2j1nA:
undetectable		 5g5gB-2j1nA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kmg KLCA

(Bordetella
pertussis) 		PF03230
(Antirestrict) 		3 THR A 111
ASP A 112
ALA A 113
 None
 0.00A 5g5gB-2kmgA:
undetectable		 5g5gB-2kmgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntb PECTINESTERASE A

(Dickeya
dadantii) 		PF01095
(Pectinesterase) 		3 THR A 345
ASP A 346
ALA A 347
 None
 0.11A 5g5gB-2ntbA:
undetectable		 5g5gB-2ntbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2or0 HYDROXYLASE

(Rhodococcus
jostii) 		PF08028
(Acyl-CoA_dh_2) 		3 THR A  29
ASP A  30
ALA A  31
 None
 0.08A 5g5gB-2or0A:
undetectable		 5g5gB-2or0A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		3 THR A 149
ASP A 150
ALA A 151
 None
 0.11A 5g5gB-2q01A:
undetectable		 5g5gB-2q01A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q17 FORMYLGLYCINE
GENERATING ENZYME

(Streptomyces
coelicolor) 		PF03781
(FGE-sulfatase) 		3 THR A  83
ASP A  84
ALA A  85
 None
 0.07A 5g5gB-2q17A:
undetectable		 5g5gB-2q17A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf9 PUTATIVE SECRETED
PROTEIN

(Streptomyces
coelicolor) 		PF03713
(DUF305) 		3 THR A 131
ASP A 132
ALA A 133
 None
 0.00A 5g5gB-2qf9A:
undetectable		 5g5gB-2qf9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpm CYTOKININ
DEHYDROGENASE 1

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		3 THR A 308
ASP A 309
ALA A 310
 None
 0.09A 5g5gB-2qpmA:
5.6		 5g5gB-2qpmA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r14 MORPHINONE REDUCTASE

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		3 THR A  80
ASP A  81
ALA A  82
 None
 0.10A 5g5gB-2r14A:
undetectable		 5g5gB-2r14A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9z CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		3 THR A 282
ASP A 283
ALA A 284
 None
 0.11A 5g5gB-2x9zA:
undetectable		 5g5gB-2x9zA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt0 HALOALKANE
DEHALOGENASE

(Plesiocystis
pacifica) 		PF00561
(Abhydrolase_1) 		3 THR A 187
ASP A 188
ALA A 189
 None
 0.00A 5g5gB-2xt0A:
undetectable		 5g5gB-2xt0A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y2c 1,6-ANHYDRO-N-ACETYL
MURAMYL-L-ALANINE
AMIDASE AMPD

(Citrobacter
freundii) 		PF01510
(Amidase_2) 		3 THR A 126
ASP A 127
ALA A 128
 None
 0.07A 5g5gB-2y2cA:
undetectable		 5g5gB-2y2cA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywq RIBOSOMAL SUBUNIT
INTERFACE PROTEIN

(Thermus
thermophilus) 		PF02482
(Ribosomal_S30AE) 		3 THR A  14
ASP A  15
ALA A  16
 None
 0.02A 5g5gB-2ywqA:
undetectable		 5g5gB-2ywqA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq7 GROUP 1 TRUNCATED
HEMOGLOBIN

(Tetrahymena
pyriformis) 		PF01152
(Bac_globin) 		3 THR A 100
ASP A 101
ALA A 102
 None
 0.08A 5g5gB-3aq7A:
undetectable		 5g5gB-3aq7A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE

(Mesorhizobium
japonicum) 		PF08241
(Methyltransf_11) 		3 THR A 216
ASP A 217
ALA A 218
 None
 0.06A 5g5gB-3bkwA:
undetectable		 5g5gB-3bkwA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clm TRANSALDOLASE

(Neisseria
gonorrhoeae) 		PF00923
(TAL_FSA) 		3 THR A 142
ASP A 143
ALA A 144
 None
 0.00A 5g5gB-3clmA:
undetectable		 5g5gB-3clmA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwk METHYLCITRATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00285
(Citrate_synt) 		3 THR A  82
ASP A  83
ALA A  84
 None
 0.00A 5g5gB-3hwkA:
undetectable		 5g5gB-3hwkA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivp PUTATIVE
TRANSPOSON-RELATED
DNA-BINDING PROTEIN

(Clostridioides
difficile) 		PF01381
(HTH_3) 		3 THR A  95
ASP A  96
ALA A  97
 None
 0.09A 5g5gB-3ivpA:
undetectable		 5g5gB-3ivpA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsk CYPBP37 PROTEIN

(Neurospora
crassa) 		PF01946
(Thi4) 		3 THR A  49
ASP A  50
ALA A  51
 None
 0.08A 5g5gB-3jskA:
undetectable		 5g5gB-3jskA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l06 N-ACETYLORNITHINE
CARBAMOYLTRANSFERASE

(Xanthomonas
campestris) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 THR A 304
ASP A 305
ALA A 306
 None
 0.10A 5g5gB-3l06A:
undetectable		 5g5gB-3l06A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 THR A 433
ASP A 434
ALA A 435
 None
 0.10A 5g5gB-3lkdA:
undetectable		 5g5gB-3lkdA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		3 THR A 296
ASP A 297
ALA A 298
 None
 0.07A 5g5gB-3mc2A:
undetectable		 5g5gB-3mc2A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n11 CHITINASE A

(Bacillus cereus) 		PF00704
(Glyco_hydro_18) 		3 THR A  84
ASP A  85
ALA A  86
 None
 0.04A 5g5gB-3n11A:
undetectable		 5g5gB-3n11A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nda SERPIN-2

(Ixodes ricinus) 		PF00079
(Serpin) 		3 THR A  68
ASP A  69
ALA A  70
 None
 0.08A 5g5gB-3ndaA:
undetectable		 5g5gB-3ndaA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE

(Klebsiella
pneumoniae) 		PF00266
(Aminotran_5) 		3 THR A 233
ASP A 234
ALA A 235
 None
 0.07A 5g5gB-3nnkA:
undetectable		 5g5gB-3nnkA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc6 6-PHOSPHOGLUCONOLACT
ONASE

(Mycolicibacterium
smegmatis) 		PF01182
(Glucosamine_iso) 		3 THR A 159
ASP A 160
ALA A 161
 None
 0.09A 5g5gB-3oc6A:
undetectable		 5g5gB-3oc6A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owv DNA-ENTRY NUCLEASE

(Streptococcus
pneumoniae) 		PF01223
(Endonuclease_NS) 		3 THR A  59
ASP A  60
ALA A  61
 None
 0.05A 5g5gB-3owvA:
undetectable		 5g5gB-3owvA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 THR B 354
ASP B 355
ALA B 356
 None
 0.11A 5g5gB-3pcoB:
undetectable		 5g5gB-3pcoB:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf2 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		3 THR A 414
ASP A 415
ALA A 416
 None
 0.00A 5g5gB-3pf2A:
undetectable		 5g5gB-3pf2A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pig BETA-FRUCTOFURANOSID
ASE

(Bifidobacterium
longum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 THR A 449
ASP A 450
ALA A 451
 None
 0.05A 5g5gB-3pigA:
undetectable		 5g5gB-3pigA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2l PUTATIVE CELL
ADHESION PROTEIN

(Bacteroides
fragilis) 		PF13149
(Mfa_like_1) 		3 THR A 226
ASP A 227
ALA A 228
 None
 0.05A 5g5gB-3t2lA:
undetectable		 5g5gB-3t2lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqu NON-CANONICAL PURINE
NTP PYROPHOSPHATASE

(Coxiella
burnetii) 		PF01725
(Ham1p_like) 		3 THR A  94
ASP A  95
ALA A  96
 None
 0.07A 5g5gB-3tquA:
undetectable		 5g5gB-3tquA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE

(Mycobacteroides
abscessus) 		PF01182
(Glucosamine_iso) 		3 THR A 161
ASP A 162
ALA A 163
 None
 0.06A 5g5gB-3tx2A:
undetectable		 5g5gB-3tx2A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 THR A 553
ASP A 554
ALA A 555
 None
 0.10A 5g5gB-3uk1A:
undetectable		 5g5gB-3uk1A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Rhodobacter
sphaeroides) 		PF13561
(adh_short_C2) 		3 THR A  92
ASP A  93
ALA A  94
 None
 0.00A 5g5gB-3uxyA:
undetectable		 5g5gB-3uxyA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgc L-ALLO-THREONINE
ALDOLASE

(Aeromonas
jandaei) 		PF01212
(Beta_elim_lyase) 		3 THR A  15
ASP A  16
ALA A  17
 None
 0.00A 5g5gB-3wgcA:
undetectable		 5g5gB-3wgcA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz1 AGARASE

(Microbulbifer
thermotolerans) 		PF00722
(Glyco_hydro_16) 		3 THR A 270
ASP A 271
ALA A 272
 None
 0.08A 5g5gB-3wz1A:
undetectable		 5g5gB-3wz1A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		3 THR A 408
ASP A 409
ALA A 410
 GOL  A1436 ( 4.8A)
None
None
 0.10A 5g5gB-4aoaA:
undetectable		 5g5gB-4aoaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cg1 CUTINASE

(Thermobifida
fusca) 		PF12740
(Chlorophyllase2) 		3 THR A  11
ASP A  12
ALA A  13
 None
 0.06A 5g5gB-4cg1A:
undetectable		 5g5gB-4cg1A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee1 DNA PRIMASE

(Staphylococcus
aureus) 		PF08275
(Toprim_N)
PF13155
(Toprim_2) 		3 THR A 149
ASP A 150
ALA A 151
 None
 0.00A 5g5gB-4ee1A:
undetectable		 5g5gB-4ee1A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewt PEPTIDASE,
M20/M25/M40 FAMILY

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 THR A 263
ASP A 264
ALA A 265
 None
 0.08A 5g5gB-4ewtA:
undetectable		 5g5gB-4ewtA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfj TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		3 THR A 508
ASP A 509
ALA A 510
 None
 0.05A 5g5gB-4gfjA:
undetectable		 5g5gB-4gfjA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2l BETA GLOBIN

(Peromyscus
maniculatus) 		PF00042
(Globin) 		3 THR B   4
ASP B   5
ALA B   6
 None
 0.10A 5g5gB-4h2lB:
undetectable		 5g5gB-4h2lB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j20 CYTOCHROME C-555

(Chlorobaculum
tepidum) 		PF13442
(Cytochrome_CBB3) 		3 THR A  72
ASP A  73
ALA A  74
 IPA  A 105 ( 4.8A)
None
IPA  A 102 ( 4.0A)
 0.07A 5g5gB-4j20A:
undetectable		 5g5gB-4j20A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k70 UL37

(Suid
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		3 THR A 361
ASP A 362
ALA A 363
 None
GOL  A1001 (-4.7A)
None
 0.00A 5g5gB-4k70A:
undetectable		 5g5gB-4k70A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		3 THR A 246
ASP A 247
ALA A 248
 None
 0.01A 5g5gB-4mniA:
undetectable		 5g5gB-4mniA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx2 ADENYLOSUCCINATE
LYASE

(Leishmania
donovani) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		3 THR A  86
ASP A  87
ALA A  88
 None
 0.07A 5g5gB-4mx2A:
undetectable		 5g5gB-4mx2A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		3 THR A 383
ASP A 384
ALA A 385
 None
 0.00A 5g5gB-4n78A:
undetectable		 5g5gB-4n78A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nur PSDSA

(Pseudomonas sp.
S9) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		3 THR A  49
ASP A  50
ALA A  51
 None
 0.00A 5g5gB-4nurA:
undetectable		 5g5gB-4nurA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oen SECOND SUBSTRATE
BINDING DOMAIN OF
PUTATIVE AMINO ACID
ABC TRANSPORTER

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		3 THR A 337
ASP A 338
ALA A 339
 ACT  A 505 (-4.2A)
ACT  A 505 (-4.0A)
ACT  A 505 (-3.6A)
 0.10A 5g5gB-4oenA:
undetectable		 5g5gB-4oenA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzj TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Eggerthella
lenta) 		PF00126
(HTH_1) 		3 THR A  58
ASP A  59
ALA A  60
 None
 0.06A 5g5gB-4pzjA:
undetectable		 5g5gB-4pzjA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Burkholderia
thailandensis) 		PF01128
(IspD) 		3 THR A  99
ASP A 100
ALA A 101
 None
 0.00A 5g5gB-4ys8A:
undetectable		 5g5gB-4ys8A:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z6i BROMODOMAIN-CONTAINI
NG PROTEIN 9

(Homo sapiens) 		PF00439
(Bromodomain) 		3 THR A  50
ASP A  51
ALA A  52
 None
 0.06A 5g5gB-4z6iA:
undetectable		 5g5gB-4z6iA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dji 3'-PHOSPHOADENOSINE
5'-PHOSPHATE
PHOSPHATASE

(Mycobacterium
tuberculosis) 		PF00459
(Inositol_P) 		3 THR A  14
ASP A  15
ALA A  16
 None
 0.00A 5g5gB-5djiA:
undetectable		 5g5gB-5djiA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN

(Thermobaculum
terrenum) 		PF13181
(TPR_8)
PF13844
(Glyco_transf_41) 		3 THR A 225
ASP A 226
ALA A 227
 None
 0.00A 5g5gB-5djsA:
undetectable		 5g5gB-5djsA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7s LON PROTEASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C) 		3 THR A 523
ASP A 524
ALA A 525
 None
 0.00A 5g5gB-5e7sA:
undetectable		 5g5gB-5e7sA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5n MONOOXYGENASE

(Micromonospora
sp. TP-A0468) 		PF05368
(NmrA) 		3 THR A  41
ASP A  42
ALA A  43
 None
 0.10A 5g5gB-5f5nA:
undetectable		 5g5gB-5f5nA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmu TRAF3-INTERACTING
PROTEIN 1

(Mus musculus) 		PF10243
(MIP-T3) 		3 THR A  54
ASP A  55
ALA A  56
 None
 0.09A 5g5gB-5fmuA:
undetectable		 5g5gB-5fmuA:
18.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT

(Escherichia
coli) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		3 THR B  62
ASP B  63
ALA B  64
 ACT  B1321 (-4.0A)
ACT  B1321 (-4.9A)
ACT  B1321 (-3.4A)
 0.00A 5g5gB-5g5gB:
56.9		 5g5gB-5g5gB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh3 OXYA PROTEIN

(Actinoplanes
teichomyceticus) 		PF00067
(p450) 		3 THR A 218
ASP A 219
ALA A 220
 None
 0.00A 5g5gB-5hh3A:
undetectable		 5g5gB-5hh3A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE

(Shewanella
oneidensis) 		PF01041
(DegT_DnrJ_EryC1) 		3 THR A 378
ASP A 379
ALA A 380
 None
 0.07A 5g5gB-5k8bA:
undetectable		 5g5gB-5k8bA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksd ATPASE 2, PLASMA
MEMBRANE-TYPE

(Arabidopsis
thaliana) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		3 THR A 609
ASP A 610
ALA A 611
 None
 0.08A 5g5gB-5ksdA:
undetectable		 5g5gB-5ksdA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdu RPB7-BINDING PROTEIN
SEB1

(Schizosaccharomyces
pombe) 		PF00076
(RRM_1) 		3 THR A 500
ASP A 501
ALA A 502
 None
 0.00A 5g5gB-5mduA:
undetectable		 5g5gB-5mduA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE

(Thermomonospora
curvata) 		PF03781
(FGE-sulfatase) 		3 THR A  77
ASP A  78
ALA A  79
 None
 0.00A 5g5gB-5nyyA:
undetectable		 5g5gB-5nyyA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1t PROTEIN NRD1

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		3 THR A 431
ASP A 432
ALA A 433
 None
 0.08A 5g5gB-5o1tA:
undetectable		 5g5gB-5o1tA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1w PROTEIN NRD1

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		3 THR A 431
ASP A 432
ALA A 433
 None
 0.00A 5g5gB-5o1wA:
undetectable		 5g5gB-5o1wA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G

(Methanothermococcus
thermolithotrophicus) 		PF01058
(Oxidored_q6) 		3 THR E 242
ASP E 243
ALA E 244
 None
 0.09A 5g5gB-5odrE:
undetectable		 5g5gB-5odrE:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tfq BETA-LACTAMASE

(Bacteroides
cellulosilyticus) 		PF13354
(Beta-lactamase2) 		3 THR A 256
ASP A 257
ALA A 258
 None
 0.10A 5g5gB-5tfqA:
undetectable		 5g5gB-5tfqA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvg ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Burkholderia
vietnamiensis) 		PF00982
(Glyco_transf_20) 		3 THR A 188
ASP A 189
ALA A 190
 None
 0.10A 5g5gB-5tvgA:
undetectable		 5g5gB-5tvgA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1h OUTER MEMBRANE PORIN
F

(Pseudomonas
aeruginosa) 		PF00691
(OmpA) 		3 THR A  55
ASP A  56
ALA A  57
 None
 0.04A 5g5gB-5u1hA:
undetectable		 5g5gB-5u1hA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wo1 PERIPLASMIC
CHAPERONE SPY

(Escherichia
coli) 		PF07813
(LTXXQ) 		3 THR A  35
ASP A  36
ALA A  37
 THR  A  35 (-0.8A)
ASP  A  36 (-0.5A)
ALA  A  37 ( 0.0A)
 0.06A 5g5gB-5wo1A:
undetectable		 5g5gB-5wo1A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xap PROTEIN TRANSLOCASE
SUBUNIT SECD

(Deinococcus
radiodurans) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		3 THR A 211
ASP A 212
ALA A 213
 None
 0.00A 5g5gB-5xapA:
undetectable		 5g5gB-5xapA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xed CYTOCHROME
C-551,CYTOCHROME
C-552

(Pseudomonas
aeruginosa;
Hydrogenobacter
thermophilus) 		PF00034
(Cytochrom_C) 		3 THR A  67
ASP A  68
ALA A  69
 None
 0.11A 5g5gB-5xedA:
undetectable		 5g5gB-5xedA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3s -

(-) 		no annotation 3 THR A 793
ASP A 794
ALA A 795
 None
 0.09A 5g5gB-5y3sA:
undetectable		 5g5gB-5y3sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydl PKS

(Streptomyces
sp. CNQ431) 		no annotation 3 THR A 308
ASP A 309
ALA A 310
 None
 0.07A 5g5gB-5ydlA:
undetectable		 5g5gB-5ydlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8m -

(-) 		no annotation 3 THR A 214
ASP A 215
ALA A 216
 None
 0.09A 5g5gB-6a8mA:
undetectable		 5g5gB-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Homo sapiens) 		no annotation 3 THR C 218
ASP C 219
ALA C 220
 None
 0.00A 5g5gB-6cajC:
undetectable		 5g5gB-6cajC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d3i -

(-) 		no annotation 3 THR A 229
ASP A 230
ALA A 231
 None
 0.09A 5g5gB-6d3iA:
undetectable		 5g5gB-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dk2 -

(-) 		no annotation 3 THR A 453
ASP A 454
ALA A 455
 EDO  A 626 (-4.0A)
EDO  A 626 (-3.9A)
EDO  A 626 (-3.5A)
 0.00A 5g5gB-6dk2A:
undetectable		 5g5gB-6dk2A:
undetectable