SIMILAR PATTERNS OF AMINO ACIDS FOR 5G08_A_Z80A1187_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE


(Homo sapiens)
PF00632
(HECT)
4 ILE A 843
PHE A 767
THR A 751
TRP A 768
None
1.23A 5g08A-1d5fA:
0.0
5g08A-1d5fA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhq PROTEIN KINASE SPK1

(Saccharomyces
cerevisiae)
PF00498
(FHA)
4 ILE A 625
TYR A 649
PHE A 624
PHE A 692
None
1.32A 5g08A-1fhqA:
undetectable
5g08A-1fhqA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fpw CALCIUM-BINDING
PROTEIN NCS-1


(Saccharomyces
cerevisiae)
PF13499
(EF-hand_7)
PF13833
(EF-hand_8)
4 ILE A  51
TYR A  52
THR A  91
TRP A 103
None
1.15A 5g08A-1fpwA:
16.0
5g08A-1fpwA:
56.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fpw CALCIUM-BINDING
PROTEIN NCS-1


(Saccharomyces
cerevisiae)
PF13499
(EF-hand_7)
PF13833
(EF-hand_8)
4 TYR A  52
PHE A  55
THR A  91
TRP A 103
None
1.28A 5g08A-1fpwA:
16.0
5g08A-1fpwA:
56.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)


(Penicillium
amagasakiense)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
4 ILE A 110
TYR A  73
THR A 335
TRP A 430
None
0.83A 5g08A-1gpeA:
2.1
5g08A-1gpeA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui)
PF00141
(peroxidase)
4 PHE A 241
PHE A 395
THR A 260
TRP A 318
HEM  A 800 ( 4.9A)
None
None
None
1.05A 5g08A-1itkA:
0.0
5g08A-1itkA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE


(Comamonas
testosteroni)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3)
4 TYR A 390
PHE A 606
THR A 442
TRP A 440
TFB  A1810 ( 3.8A)
None
None
None
1.20A 5g08A-1kb0A:
undetectable
5g08A-1kb0A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpi CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 2


(Mycobacterium
tuberculosis)
PF02353
(CMAS)
4 ILE A 276
TYR A 280
PHE A  31
TRP A  83
None
1.35A 5g08A-1kpiA:
0.0
5g08A-1kpiA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq3 GLYCEROL
DEHYDROGENASE


(Thermotoga
maritima)
PF00465
(Fe-ADH)
4 ILE A 128
TYR A 129
PHE A 135
THR A 118
None
None
None
TRS  A2922 ( 4.2A)
1.14A 5g08A-1kq3A:
undetectable
5g08A-1kq3A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltz PHENYLALANINE-4-HYDR
OXYLASE


(Chromobacterium
violaceum)
PF00351
(Biopterin_H)
4 ILE A 234
PHE A 185
THR A 119
TRP A 121
None
1.37A 5g08A-1ltzA:
0.0
5g08A-1ltzA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvg GUANYLATE KINASE

(Mus musculus)
PF00625
(Guanylate_kin)
4 ILE A 118
TYR A 119
PHE A 165
THR A  83
None
None
None
5GP  A1202 (-4.2A)
1.24A 5g08A-1lvgA:
undetectable
5g08A-1lvgA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE


(Bos taurus)
PF07748
(Glyco_hydro_38C)
4 ILE D 730
TYR D 642
PHE D 641
THR D 735
None
1.28A 5g08A-1o7dD:
undetectable
5g08A-1o7dD:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ooe DIHYDROPTERIDINE
REDUCTASE


(Caenorhabditis
elegans)
PF00106
(adh_short)
4 ILE A 201
PHE A 200
PHE A  23
THR A 210
None
1.16A 5g08A-1ooeA:
undetectable
5g08A-1ooeA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qv0 OBELIN

(Obelia
longissima)
PF00036
(EF-hand_1)
PF13202
(EF-hand_5)
4 ILE A  83
PHE A  85
PHE A  72
TRP A 114
None
None
CZH  A 201 ( 4.9A)
CZH  A 201 (-3.9A)
1.37A 5g08A-1qv0A:
3.2
5g08A-1qv0A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4c CYSTATIN C

(Homo sapiens)
PF00031
(Cystatin)
4 ILE A 101
TYR A  62
PHE A  63
TRP A 106
None
1.26A 5g08A-1r4cA:
undetectable
5g08A-1r4cA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT


(Thauera
aromatica)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
4 ILE A 280
PHE A 279
PHE A 254
THR A 212
None
1.36A 5g08A-1sb3A:
2.0
5g08A-1sb3A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw1 PROTEIN YTNJ

(Bacillus
subtilis)
PF00296
(Bac_luciferase)
4 ILE A 234
PHE A 235
PHE A 226
THR A  98
None
FMN  A2606 (-4.2A)
None
None
1.30A 5g08A-1yw1A:
undetectable
5g08A-1yw1A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE


(Streptococcus
pneumoniae)
PF03070
(TENA_THI-4)
4 ILE A 164
TYR A  95
PHE A 100
TRP A 152
None
1.37A 5g08A-1z72A:
undetectable
5g08A-1z72A:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aja ANKYRIN REPEAT
FAMILY PROTEIN


(Legionella
pneumophila)
no annotation 4 ILE A 194
TYR A 199
PHE A 202
THR A 314
None
1.17A 5g08A-2ajaA:
undetectable
5g08A-2ajaA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE


(Vitis vinifera)
PF00201
(UDPGT)
4 ILE A  87
PHE A  90
THR A 141
TRP A 140
None
None
U2F  A1457 (-3.9A)
None
1.21A 5g08A-2c1zA:
undetectable
5g08A-2c1zA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cmh SPERMIDINE SYNTHASE

(Helicobacter
pylori)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
4 ILE A 211
PHE A 192
PHE A 246
THR A  69
None
1.28A 5g08A-2cmhA:
undetectable
5g08A-2cmhA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgd 223AA LONG
HYPOTHETICAL
ARYLMALONATE
DECARBOXYLASE


(Sulfurisphaera
tokodaii)
no annotation 4 ILE A 113
TYR A 176
PHE A 134
THR A  78
None
1.16A 5g08A-2dgdA:
undetectable
5g08A-2dgdA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghi TRANSPORT PROTEIN

(Plasmodium
yoelii)
PF00005
(ABC_tran)
4 ILE A  18
PHE A  42
PHE A   5
THR A   8
None
1.34A 5g08A-2ghiA:
undetectable
5g08A-2ghiA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT


(Pseudomonas
stutzeri)
PF02332
(Phenol_Hydrox)
PF04945
(YHS)
4 ILE A 227
PHE A 220
THR A  92
TRP A  89
None
1.09A 5g08A-2incA:
undetectable
5g08A-2incA:
17.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jul CALSENILIN

(Mus musculus)
PF13499
(EF-hand_7)
PF13833
(EF-hand_8)
4 ILE A 117
PHE A 121
PHE A 138
TRP A 169
None
0.96A 5g08A-2julA:
16.6
5g08A-2julA:
32.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ls8 C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER D


(Homo sapiens)
PF00059
(Lectin_C)
4 ILE A  50
TYR A  15
PHE A  10
THR A  79
None
1.30A 5g08A-2ls8A:
undetectable
5g08A-2ls8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica)
PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3)
4 PHE A 482
PHE A 577
THR A 567
TRP A 591
None
1.21A 5g08A-2uvfA:
undetectable
5g08A-2uvfA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL


(Trypanosoma
brucei)
PF00121
(TIM)
4 ILE A   7
PHE A 231
PHE A  60
THR A  31
None
1.21A 5g08A-2x2gA:
undetectable
5g08A-2x2gA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N


(Thermosynechococcus
elongatus)
PF00148
(Oxidored_nitro)
4 ILE A 348
PHE A  11
PHE A 272
THR A 269
None
1.33A 5g08A-2xdqA:
undetectable
5g08A-2xdqA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygk NURA

(Sulfolobus
solfataricus)
PF09376
(NurA)
4 ILE A 233
PHE A 259
PHE A 210
THR A 224
None
1.35A 5g08A-2ygkA:
undetectable
5g08A-2ygkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynt GIM-1 PROTEIN

(Pseudomonas
aeruginosa)
PF00753
(Lactamase_B)
4 ILE B 187
PHE B 218
PHE B 172
THR B 142
None
0.99A 5g08A-2yntB:
undetectable
5g08A-2yntB:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywi HYPOTHETICAL
CONSERVED PROTEIN


(Geobacillus
kaustophilus)
PF00578
(AhpC-TSA)
4 ILE A  49
TYR A 133
PHE A 132
TRP A 190
None
1.37A 5g08A-2ywiA:
undetectable
5g08A-2ywiA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN


(Streptococcus
agalactiae)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
4 ILE A 658
TYR A 616
PHE A1018
THR A1024
None
1.37A 5g08A-3fawA:
undetectable
5g08A-3fawA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN


(Plexaura
homomalla)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
4 ILE A 879
TYR A 883
PHE A 882
THR A 772
GOL  A2302 (-3.7A)
None
None
None
1.12A 5g08A-3fg4A:
undetectable
5g08A-3fg4A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE


(Medicago
truncatula)
PF00201
(UDPGT)
4 ILE A  92
PHE A  95
THR A 146
TRP A 145
None
1.04A 5g08A-3hbjA:
undetectable
5g08A-3hbjA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks7 PUTATIVE PUTATIVE
PNGASE F


(Bacteroides
fragilis)
PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C)
4 ILE A 300
PHE A 311
PHE A 258
THR A 246
None
EDO  A 418 ( 4.4A)
None
None
1.26A 5g08A-3ks7A:
undetectable
5g08A-3ks7A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lms CARBOXYPEPTIDASE B2

(Homo sapiens)
PF00246
(Peptidase_M14)
4 ILE A  86
TYR A  96
PHE A  89
THR A 233
None
1.11A 5g08A-3lmsA:
undetectable
5g08A-3lmsA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA


(Archaeoglobus
fulgidus)
PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
4 PHE A 232
PHE B 364
THR A 237
TRP B 366
None
1.35A 5g08A-3mm5A:
undetectable
5g08A-3mm5A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0g ISOPRENE SYNTHASE

(Populus tremula
x Populus alba)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
4 ILE A 347
PHE A 420
THR A 389
TRP A 294
None
MG  A 621 ( 4.2A)
None
None
1.40A 5g08A-3n0gA:
2.7
5g08A-3n0gA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT


(Escherichia
coli)
PF01409
(tRNA-synt_2d)
PF02912
(Phe_tRNA-synt_N)
4 ILE A 175
PHE A 250
THR A 157
TRP A 159
None
PHE  A 980 (-4.5A)
None
None
1.36A 5g08A-3pcoA:
undetectable
5g08A-3pcoA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt3 E3 UBIQUITIN-PROTEIN
LIGASE UBR5


(Homo sapiens)
PF00632
(HECT)
4 ILE A2791
PHE A2714
THR A2694
TRP A2715
None
1.27A 5g08A-3pt3A:
undetectable
5g08A-3pt3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3h HMW1C-LIKE
GLYCOSYLTRANSFERASE


(Actinobacillus
pleuropneumoniae)
no annotation 4 ILE A 297
PHE A 315
PHE A 342
THR A 353
None
1.18A 5g08A-3q3hA:
undetectable
5g08A-3q3hA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
4 ILE A 427
PHE A 359
THR A 158
TRP A 154
None
1.33A 5g08A-3redA:
undetectable
5g08A-3redA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6i DNA-3-METHYLADENINE
GLYCOSYLASE 1


(Schizosaccharomyces
pombe)
PF00730
(HhH-GPD)
4 ILE A  71
PHE A  75
THR A 151
TRP A 150
None
1.32A 5g08A-3s6iA:
undetectable
5g08A-3s6iA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D


(Homo sapiens)
PF00233
(PDEase_I)
4 ILE A 336
PHE A 341
THR A 409
TRP A 405
ILE  A 336 ( 0.4A)
PHE  A 341 ( 1.3A)
THR  A 409 ( 0.8A)
TRP  A 405 ( 0.5A)
1.14A 5g08A-3sl5A:
undetectable
5g08A-3sl5A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vco DIHYDROFOLATE
REDUCTASE


(Schistosoma
mansoni)
PF00186
(DHFR_1)
4 ILE A 110
PHE A 109
PHE A 145
TRP A  13
None
1.28A 5g08A-3vcoA:
undetectable
5g08A-3vcoA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w8s GLUTATHIONE
S-TRANSFERASE-3


(Necator
americanus)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 ILE A  99
PHE A 132
PHE A 105
THR A 171
None
1.28A 5g08A-3w8sA:
undetectable
5g08A-3w8sA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whd C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER D


(Homo sapiens)
PF00059
(Lectin_C)
4 ILE A 131
TYR A  96
PHE A  91
THR A 160
None
1.18A 5g08A-3whdA:
undetectable
5g08A-3whdA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE


(Bacillus
circulans)
PF13199
(Glyco_hydro_66)
PF16990
(CBM_35)
4 ILE A 289
TYR A 288
PHE A 278
TRP A 186
None
1.38A 5g08A-3wnpA:
undetectable
5g08A-3wnpA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus)
PF00141
(peroxidase)
4 ILE A 387
PHE A 398
THR A 264
TRP A 321
None
None
NA  A 806 (-4.7A)
None
1.21A 5g08A-3wxoA:
undetectable
5g08A-3wxoA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus)
PF00141
(peroxidase)
4 PHE A 245
PHE A 398
THR A 264
TRP A 321
HEM  A 801 (-4.6A)
None
NA  A 806 (-4.7A)
None
0.93A 5g08A-3wxoA:
undetectable
5g08A-3wxoA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae5 SIGNAL TRANSDUCTION
PROTEIN TRAP


(Staphylococcus
aureus)
no annotation 4 ILE A  73
TYR A 157
PHE A 158
PHE A 135
None
1.30A 5g08A-4ae5A:
undetectable
5g08A-4ae5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aef NEOPULLULANASE
(ALPHA-AMYLASE II)


(Pyrococcus
furiosus)
PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16561
(AMPK1_CBM)
4 ILE A 300
PHE A 298
PHE A 217
TRP A 557
None
1.30A 5g08A-4aefA:
undetectable
5g08A-4aefA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awe ENDO-BETA-D-1,4-MANN
ANASE


(Neurospora
sitophila)
PF00150
(Cellulase)
4 TYR A 159
PHE A 156
PHE A 103
THR A  56
None
1.21A 5g08A-4aweA:
undetectable
5g08A-4aweA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsn EXPORTIN-1

(Homo sapiens)
PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C)
4 ILE A 547
TYR A 551
PHE A 516
THR A 472
None
1.10A 5g08A-4bsnA:
undetectable
5g08A-4bsnA:
10.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4by4 FI18190P1

(Drosophila
melanogaster)
PF00036
(EF-hand_1)
PF13499
(EF-hand_7)
5 ILE A  51
TYR A  52
PHE A  72
THR A  92
TRP A 103
None
0.43A 5g08A-4by4A:
23.6
5g08A-4by4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4by4 FI18190P1

(Drosophila
melanogaster)
PF00036
(EF-hand_1)
PF13499
(EF-hand_7)
5 TYR A  52
PHE A  55
PHE A  72
THR A  92
TRP A 103
None
0.81A 5g08A-4by4A:
23.6
5g08A-4by4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4by4 FI18190P1

(Drosophila
melanogaster)
PF00036
(EF-hand_1)
PF13499
(EF-hand_7)
5 TYR A  52
PHE A  56
PHE A  72
THR A  92
TRP A 103
None
1.43A 5g08A-4by4A:
23.6
5g08A-4by4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9y SPINDLE AND
KINETOCHORE-ASSOCIAT
ED PROTEIN 1


(Homo sapiens)
PF07160
(SKA1)
4 ILE A  30
PHE A   8
PHE A  97
THR A  89
None
1.32A 5g08A-4c9yA:
undetectable
5g08A-4c9yA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d05 ATP-DEPENDENT DNA
LIGASE


(Psychromonas
sp. SP041)
PF01068
(DNA_ligase_A_M)
PF14743
(DNA_ligase_OB_2)
4 ILE A  96
PHE A  97
PHE A  52
TRP A  89
None
AMP  A1263 (-3.4A)
None
None
1.30A 5g08A-4d05A:
undetectable
5g08A-4d05A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d72 GLYCOSIDE HYDROLASE

(Streptococcus
pneumoniae)
PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C)
4 ILE A 939
TYR A 938
PHE A 944
THR A 969
None
1.30A 5g08A-4d72A:
undetectable
5g08A-4d72A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk1 PUTATIVE THIOREDOXIN
REDUCTASE


(Bacillus
anthracis)
PF07992
(Pyr_redox_2)
4 ILE C 227
TYR C 126
PHE C 131
PHE C 231
None
FAD  C 500 (-4.3A)
None
None
1.31A 5g08A-4fk1C:
undetectable
5g08A-4fk1C:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE


(Thermothelomyces
thermophila)
no annotation 4 ILE A 109
PHE A 169
PHE A 146
THR A 222
None
1.27A 5g08A-4g4iA:
undetectable
5g08A-4g4iA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr8 MACROPHAGE
METALLOELASTASE


(Homo sapiens)
PF00413
(Peptidase_M10)
4 ILE A 134
PHE A 213
PHE A 149
THR A 145
None
1.25A 5g08A-4gr8A:
undetectable
5g08A-4gr8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE


(Solanum
lycopersicum)
PF00171
(Aldedh)
4 ILE A 287
PHE A 285
PHE A 396
TRP A 161
None
None
NAD  A 601 (-3.9A)
NAD  A 601 (-3.9A)
1.08A 5g08A-4i8qA:
undetectable
5g08A-4i8qA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR


(Xanthobacter
autotrophicus)
PF13561
(adh_short_C2)
4 ILE A 150
TYR A 156
PHE A  97
THR A 192
1HS  A 302 ( 4.3A)
1HS  A 302 ( 4.3A)
None
NAI  A 301 (-2.8A)
1.29A 5g08A-4ituA:
undetectable
5g08A-4ituA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2


(Homo sapiens)
no annotation 4 ILE A  44
PHE A  70
PHE A 120
THR A 304
None
1.25A 5g08A-4nzmA:
undetectable
5g08A-4nzmA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A


(Pseudomonas
mendocina)
PF02332
(Phenol_Hydrox)
4 ILE A 227
PHE A 220
THR A  92
TRP A  89
None
1.09A 5g08A-4p1cA:
undetectable
5g08A-4p1cA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO


(Escherichia
coli)
PF02624
(YcaO)
4 ILE A 244
PHE A 242
PHE A 335
TRP A 332
None
0.73A 5g08A-4q85A:
undetectable
5g08A-4q85A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tq5 PRENYLTRANSFERASE

(Archaeoglobus
fulgidus)
PF01040
(UbiA)
4 ILE A 292
PHE A 291
PHE A  57
TRP A  60
None
1.34A 5g08A-4tq5A:
undetectable
5g08A-4tq5A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE


(Escherichia
coli)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 ILE A 345
PHE A 326
PHE A 142
THR A 171
None
1.33A 5g08A-4uekA:
undetectable
5g08A-4uekA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE


(Bacillus
licheniformis)
PF01019
(G_glu_transpept)
4 ILE A 281
TYR A 276
PHE A 490
THR A 323
None
1.26A 5g08A-4y23A:
undetectable
5g08A-4y23A:
15.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yru NEURONAL CALCIUM
SENSOR 1


(Rattus
norvegicus)
PF00036
(EF-hand_1)
PF13499
(EF-hand_7)
5 ILE A  51
TYR A  52
PHE A  72
THR A  92
TRP A 103
None
0.54A 5g08A-4yruA:
21.0
5g08A-4yruA:
70.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1x LAGLIDADG
ENDONUCLEASE


(Fusarium
graminearum)
PF00961
(LAGLIDADG_1)
4 PHE A 219
PHE A 173
THR A  95
TRP A 169
None
1.30A 5g08A-4z1xA:
undetectable
5g08A-4z1xA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zet C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER C


(Homo sapiens)
PF00059
(Lectin_C)
4 ILE A 130
TYR A  95
PHE A  90
THR A 159
None
1.35A 5g08A-4zetA:
undetectable
5g08A-4zetA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgp CELL DIVISION CYCLE
PROTEIN 123


(Schizosaccharomyces
pombe)
PF07065
(D123)
4 ILE A 209
PHE A 178
THR A 247
TRP A 254
None
1.31A 5g08A-4zgpA:
undetectable
5g08A-4zgpA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A


(Oryctolagus
cuniculus)
PF01399
(PCI)
4 ILE A 446
PHE A 493
PHE A 398
THR A 435
None
1.30A 5g08A-5a5tA:
undetectable
5g08A-5a5tA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82

(Chaetomium
thermophilum)
no annotation 4 ILE B 427
PHE B 473
PHE B 492
THR B 478
None
1.14A 5g08A-5cwwB:
undetectable
5g08A-5cwwB:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl7 PORIN

(Acinetobacter
baumannii)
PF03573
(OprD)
4 ILE A 207
TYR A 208
PHE A 174
THR A 284
None
1.28A 5g08A-5dl7A:
undetectable
5g08A-5dl7A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCATS-A

(synthetic
construct)
PF00290
(Trp_syntA)
4 ILE A  52
PHE A  54
PHE A  22
THR A 183
None
None
G3P  A 301 ( 4.4A)
G3P  A 301 (-3.9A)
1.24A 5g08A-5ey5A:
0.5
5g08A-5ey5A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN


(Alicyclobacillus
acidocaldarius)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2)
4 ILE A 256
TYR A 253
THR A 203
TRP A 201
None
1.21A 5g08A-5gj8A:
undetectable
5g08A-5gj8A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxd AMP-DEPENDENT
SYNTHETASE AND
LIGASE


(Dinoroseobacter
shibae)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N)
4 ILE A 350
PHE A 349
PHE A 330
TRP A 277
None
1.19A 5g08A-5gxdA:
undetectable
5g08A-5gxdA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihe DNA POLYMERASE II
SMALL SUBUNIT


(Pyrococcus
abyssi)
PF00149
(Metallophos)
4 ILE A 401
PHE A 445
PHE A 376
TRP A 379
None
1.11A 5g08A-5iheA:
undetectable
5g08A-5iheA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j72 PUTATIVE
N-ACETYLMURAMOYL-L-A
LANINE
AMIDASE,AUTOLYSIN
CWP6


(Clostridioides
difficile)
PF01520
(Amidase_3)
PF04122
(CW_binding_2)
4 ILE A 363
TYR A 367
PHE A 366
THR A 183
None
0.81A 5g08A-5j72A:
undetectable
5g08A-5j72A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus)
PF00972
(Flavi_NS5)
PF01728
(FtsJ)
4 ILE A 670
PHE A 674
THR A 376
TRP A 379
None
1.17A 5g08A-5jjrA:
undetectable
5g08A-5jjrA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzw AEROLYSIN

(Aeromonas
hydrophila)
PF01117
(Aerolysin)
PF03440
(APT)
4 ILE A 302
PHE A 404
PHE A 410
THR A 223
None
1.25A 5g08A-5jzwA:
undetectable
5g08A-5jzwA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzw AEROLYSIN

(Aeromonas
hydrophila)
PF01117
(Aerolysin)
PF03440
(APT)
4 ILE A 302
PHE A 404
PHE A 410
THR A 275
None
0.89A 5g08A-5jzwA:
undetectable
5g08A-5jzwA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2


(Bos taurus)
PF00361
(Proton_antipo_M)
PF06444
(NADH_dehy_S2_C)
4 ILE N 209
TYR N 208
PHE N 216
THR N 119
None
0.89A 5g08A-5lc5N:
undetectable
5g08A-5lc5N:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1


(Francisella
tularensis)
no annotation 4 ILE A1286
TYR A1291
PHE A1294
THR A 927
None
1.01A 5g08A-5ng6A:
undetectable
5g08A-5ng6A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nop ATTACHMENT
GLYCOPROTEIN


(Mojiang
henipavirus)
PF00423
(HN)
4 ILE A 600
PHE A 515
PHE A 203
THR A 581
None
1.36A 5g08A-5nopA:
undetectable
5g08A-5nopA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium)
PF02310
(B12-binding)
4 ILE A 546
TYR A 552
PHE A 320
PHE A 585
None
None
SAM  A 803 (-4.5A)
None
1.23A 5g08A-5ul4A:
1.5
5g08A-5ul4A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w19 TRYPTOPHANASE

(Proteus
vulgaris)
no annotation 4 ILE A 218
PHE A 219
PHE A 167
THR A 190
None
None
None
9TD  A 502 ( 4.5A)
1.17A 5g08A-5w19A:
undetectable
5g08A-5w19A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN


(Pyrococcus
horikoshii)
PF03065
(Glyco_hydro_57)
PF09210
(DUF1957)
4 ILE A 258
PHE A 253
PHE A 221
THR A   6
None
1.15A 5g08A-5wu7A:
undetectable
5g08A-5wu7A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE


(unidentified)
PF00465
(Fe-ADH)
4 ILE A 130
TYR A 131
PHE A 137
THR A 120
None
1.14A 5g08A-5xn8A:
undetectable
5g08A-5xn8A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum)
no annotation 4 ILE A 257
PHE A 238
THR A 422
TRP A 424
None
1.30A 5g08A-5xqoA:
undetectable
5g08A-5xqoA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2


(Homo sapiens)
no annotation 4 ILE i 209
TYR i 208
PHE i 216
THR i 119
PLX  g 201 ( 4.6A)
None
None
None
0.96A 5g08A-5xtci:
undetectable
5g08A-5xtci:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7y ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ARYL HYDROCARBON
RECEPTOR REPRESSOR


(Bos taurus;
Homo sapiens)
PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11)
4 ILE B 369
PHE B 412
PHE B 446
TRP A 177
None
1.29A 5g08A-5y7yB:
undetectable
5g08A-5y7yB:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cpy GRMZM2G135359
PSEUDOKINASE


(Zea mays)
no annotation 4 ILE A 251
PHE A 306
PHE A 228
THR A 301
None
1.12A 5g08A-6cpyA:
undetectable
5g08A-6cpyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fc0 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-LIKE PROTEIN
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4G


(Chaetomium
thermophilum)
no annotation 4 TYR B1000
PHE B 998
PHE B1008
THR A  35
None
1.30A 5g08A-6fc0B:
undetectable
5g08A-6fc0B:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2


(Mus musculus)
no annotation 4 ILE N 209
TYR N 208
PHE N 216
THR N 119
None
0.74A 5g08A-6g72N:
undetectable
5g08A-6g72N:
21.38