SIMILAR PATTERNS OF AMINO ACIDS FOR 5FUK_A_SNPA1236_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlj UDP-GLUCOSE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 ILE A 346
ILE A 343
ILE A 376
LEU A 338
 None
 0.82A 5fukA-1dljA:
0.0
5fukB-1dljA:
0.0		 5fukA-1dljA:
20.25
5fukB-1dljA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
SMALL SUBUNIT

(Desulfovibrio
desulfuricans) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 ILE A  32
THR A  47
ILE A  48
LEU A  24
 None
 0.68A 5fukA-1e3dA:
undetectable
5fukB-1e3dA:
undetectable		 5fukA-1e3dA:
22.26
5fukB-1e3dA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eom ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F3

(Elizabethkingia
meningoseptica) 		PF00704
(Glyco_hydro_18) 		4 ILE A  12
ILE A 185
SER A 124
LEU A 210
 None
 0.62A 5fukA-1eomA:
undetectable
5fukB-1eomA:
undetectable		 5fukA-1eomA:
24.27
5fukB-1eomA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7u 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Escherichia
coli) 		PF00793
(DAHP_synth_1) 		4 ILE A 238
THR A  45
ILE A  50
PHE A 263
 None
 0.64A 5fukA-1g7uA:
0.1
5fukB-1g7uA:
0.0		 5fukA-1g7uA:
23.41
5fukB-1g7uA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4w TRYPSIN IVA

(Homo sapiens) 		PF00089
(Trypsin) 		4 ILE A 106
ILE A  47
THR A 241
ILE A 242
 None
 0.79A 5fukA-1h4wA:
undetectable
5fukB-1h4wA:
undetectable		 5fukA-1h4wA:
20.23
5fukB-1h4wA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98

(Homo sapiens) 		PF04096
(Nucleoporin2) 		4 ILE A 774
THR A 726
ILE A 750
LEU A 769
 None
 0.79A 5fukA-1ko6A:
undetectable
5fukB-1ko6A:
undetectable		 5fukA-1ko6A:
20.75
5fukB-1ko6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n31 L-CYSTEINE/CYSTINE
LYASE C-DES

(Synechocystis
sp. PCC 6714) 		PF00266
(Aminotran_5) 		4 ILE A 130
ILE A 162
ILE A 120
LEU A 195
 None
 0.82A 5fukA-1n31A:
0.0
5fukB-1n31A:
0.0		 5fukA-1n31A:
20.81
5fukB-1n31A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7r HYALURONIDASE

(Streptococcus
pneumoniae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 ILE A 696
ILE A 742
PHE A 746
LEU A 596
 None
 0.75A 5fukA-1n7rA:
0.0
5fukB-1n7rA:
0.0		 5fukA-1n7rA:
13.71
5fukB-1n7rA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7u ADSORPTION PROTEIN
P2

(Salmonella
virus PRD1) 		PF09214
(Prd1-P2) 		4 ILE A 491
ILE A 494
PHE A 523
LEU A 454
 None
 0.79A 5fukA-1n7uA:
undetectable
5fukB-1n7uA:
undetectable		 5fukA-1n7uA:
17.35
5fukB-1n7uA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nww LIMONENE-1,2-EPOXIDE
HYDROLASE

(Rhodococcus
erythropolis) 		PF07858
(LEH) 		4 ILE A   5
ILE A  80
ILE A 116
LEU A  35
 None
HPN  A 900 ( 4.4A)
None
None
 0.81A 5fukA-1nwwA:
undetectable
5fukB-1nwwA:
undetectable		 5fukA-1nwwA:
21.16
5fukB-1nwwA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Aquifex
aeolicus) 		PF01746
(tRNA_m1G_MT) 		4 ILE A  70
THR A  89
ILE A  88
LEU A  11
 None
 0.76A 5fukA-1oy5A:
0.0
5fukB-1oy5A:
0.0		 5fukA-1oy5A:
19.85
5fukB-1oy5A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8c HYPOTHETICAL PROTEIN
MG027

(Mycoplasma
genitalium) 		PF09185
(DUF1948) 		4 ILE A  75
ILE A  68
ILE A  25
LEU A  32
 None
IOD  A 154 ( 4.5A)
None
IOD  A 154 ( 4.9A)
 0.67A 5fukA-1q8cA:
undetectable
5fukB-1q8cA:
undetectable		 5fukA-1q8cA:
21.52
5fukB-1q8cA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td6 HYPOTHETICAL PROTEIN
MG237 HOMOLOG

(Mycoplasma
pneumoniae) 		PF11428
(DUF3196) 		4 ILE A 197
ILE A 232
PHE A 160
LEU A 210
 None
 0.80A 5fukA-1td6A:
0.0
5fukB-1td6A:
0.5		 5fukA-1td6A:
21.36
5fukB-1td6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN

(Pseudomonas
aeruginosa) 		PF04958
(AstA) 		4 ILE A 267
ILE A 239
PHE A 245
LEU A 291
 None
 0.81A 5fukA-1yleA:
0.3
5fukB-1yleA:
0.1		 5fukA-1yleA:
22.95
5fukB-1yleA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bd0 SEPIAPTERIN
REDUCTASE

(Chlorobaculum
tepidum) 		PF00106
(adh_short) 		4 ILE A  87
THR A   8
PHE A  22
LEU A 128
 None
 0.63A 5fukA-2bd0A:
0.0
5fukB-2bd0A:
0.0		 5fukA-2bd0A:
22.30
5fukB-2bd0A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens) 		PF00026
(Asp) 		4 ILE A  45
ILE A  64
THR A 117
ILE A 118
 None
 0.71A 5fukA-2ewyA:
undetectable
5fukB-2ewyA:
undetectable		 5fukA-2ewyA:
21.68
5fukB-2ewyA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzr APOLIPOPROTEIN D

(Homo sapiens) 		PF08212
(Lipocalin_2) 		4 ILE A 128
ILE A  32
THR A 148
ILE A 152
 None
 0.78A 5fukA-2hzrA:
undetectable
5fukB-2hzrA:
undetectable		 5fukA-2hzrA:
22.58
5fukB-2hzrA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuu DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		4 ILE A 646
ILE A 663
ILE A 650
LEU A 664
 None
 0.83A 5fukA-2iuuA:
undetectable
5fukB-2iuuA:
undetectable		 5fukA-2iuuA:
20.00
5fukB-2iuuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jj7 HEMOLYSIN II
REGULATORY PROTEIN

(Bacillus cereus) 		PF00440
(TetR_N) 		4 ILE A 147
ILE A 132
THR A 155
ILE A 154
 None
 0.81A 5fukA-2jj7A:
undetectable
5fukB-2jj7A:
undetectable		 5fukA-2jj7A:
23.75
5fukB-2jj7A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l5p LIPOCALIN 12

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		4 ILE A 175
THR A 167
ILE A 166
PHE A 190
 None
 0.81A 5fukA-2l5pA:
undetectable
5fukB-2l5pA:
undetectable		 5fukA-2l5pA:
21.14
5fukB-2l5pA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p58 PUTATIVE TYPE III
SECRETION PROTEIN
YSCF
PUTATIVE TYPE III
SECRETION PROTEIN
YSCG

(Yersinia pestis) 		PF09392
(T3SS_needle_F)
PF09477
(Type_III_YscG) 		4 ILE C 102
THR B  70
ILE B  71
SER B  74
 None
 0.71A 5fukA-2p58C:
undetectable
5fukB-2p58C:
undetectable		 5fukA-2p58C:
20.09
5fukB-2p58C:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pge MENC

(Desulfotalea
psychrophila) 		PF13378
(MR_MLE_C) 		4 ILE A 185
ILE A 158
ILE A 200
LEU A 181
 None
 0.71A 5fukA-2pgeA:
undetectable
5fukB-2pgeA:
undetectable		 5fukA-2pgeA:
21.64
5fukB-2pgeA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pju PROPIONATE
CATABOLISM OPERON
REGULATORY PROTEIN

(Escherichia
coli) 		PF06506
(PrpR_N) 		4 ILE A  39
ILE A  42
ILE A  65
PHE A 186
 None
 0.75A 5fukA-2pjuA:
undetectable
5fukB-2pjuA:
undetectable		 5fukA-2pjuA:
22.81
5fukB-2pjuA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnm PROTEASE VP4

(Infectious
pancreatic
necrosis virus) 		PF01768
(Birna_VP4) 		4 ILE A 564
ILE A 542
ILE A 613
LEU A 560
 None
 0.80A 5fukA-2pnmA:
undetectable
5fukB-2pnmA:
undetectable		 5fukA-2pnmA:
22.48
5fukB-2pnmA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzb UNCHARACTERIZED
PROTEIN YFEY

(Escherichia
coli) 		PF06572
(DUF1131) 		4 ILE A 158
ILE A 107
ILE A 114
LEU A  49
 None
 0.83A 5fukA-2qzbA:
undetectable
5fukB-2qzbA:
undetectable		 5fukA-2qzbA:
20.75
5fukB-2qzbA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vml PHYCOCYANIN ALPHA
CHAIN

(Gloeobacter
violaceus) 		PF00502
(Phycobilisome) 		4 ILE A 134
THR A  94
ILE A  93
LEU A  51
 None
 0.82A 5fukA-2vmlA:
undetectable
5fukB-2vmlA:
undetectable		 5fukA-2vmlA:
21.01
5fukB-2vmlA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnu EXOSOME COMPLEX
EXONUCLEASE RRP44

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		4 ILE D 425
ILE D 449
ILE D 436
LEU D 444
 None
 0.74A 5fukA-2vnuD:
undetectable
5fukB-2vnuD:
undetectable		 5fukA-2vnuD:
16.84
5fukB-2vnuD:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woo ATPASE GET3

(Schizosaccharomyces
pombe) 		PF02374
(ArsA_ATPase) 		4 ILE A 242
ILE A 250
PHE A 292
LEU A 158
 None
 0.80A 5fukA-2wooA:
undetectable
5fukB-2wooA:
undetectable		 5fukA-2wooA:
23.62
5fukB-2wooA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF13638
(PIN_4)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		4 ILE J 425
ILE J 449
ILE J 436
LEU J 444
 None
 0.62A 5fukA-2wp8J:
undetectable
5fukB-2wp8J:
undetectable		 5fukA-2wp8J:
14.72
5fukB-2wp8J:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdf PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 ILE A 330
ILE A 377
ILE A 424
PHE A 448
 None
 0.78A 5fukA-2xdfA:
undetectable
5fukB-2xdfA:
undetectable		 5fukA-2xdfA:
17.25
5fukB-2xdfA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA

(Homo sapiens) 		PF01504
(PIP5K) 		4 ILE A 194
ILE A 360
ILE A 158
LEU A 175
 None
PHD  A 359 ( 4.1A)
None
None
 0.59A 5fukA-2ybxA:
undetectable
5fukB-2ybxA:
undetectable		 5fukA-2ybxA:
19.40
5fukB-2ybxA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ILE A 165
ILE A 220
PHE A 170
LEU A 213
 None
 0.63A 5fukA-2z81A:
undetectable
5fukB-2z81A:
undetectable		 5fukA-2z81A:
19.20
5fukB-2z81A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP C

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ILE C 119
ILE C  25
ILE C  49
LEU C  27
 None
 0.81A 5fukA-3aizC:
undetectable
5fukB-3aizC:
undetectable		 5fukA-3aizC:
21.17
5fukB-3aizC:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcq ALPHA-CHAIN
HEMOGLOBIN

(Brycon cephalus) 		PF00042
(Globin) 		4 ILE A  17
ILE A  10
SER A   9
LEU A 110
 None
 0.82A 5fukA-3bcqA:
undetectable
5fukB-3bcqA:
undetectable		 5fukA-3bcqA:
22.81
5fukB-3bcqA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0r UBIQUITIN
THIOESTERASE OTU1

(Saccharomyces
cerevisiae) 		PF02338
(OTU) 		4 ILE A 179
ILE A 169
SER A 174
LEU A 158
 None
 0.80A 5fukA-3c0rA:
undetectable
5fukB-3c0rA:
undetectable		 5fukA-3c0rA:
21.54
5fukB-3c0rA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2) 		4 ILE A 750
ILE A 758
SER A 775
PHE A 776
 None
 0.75A 5fukA-3d3mA:
undetectable
5fukB-3d3mA:
undetectable		 5fukA-3d3mA:
20.68
5fukB-3d3mA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2) 		4 ILE A 758
ILE A 771
SER A 775
PHE A 776
 None
 0.62A 5fukA-3d3mA:
undetectable
5fukB-3d3mA:
undetectable		 5fukA-3d3mA:
20.68
5fukB-3d3mA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfa CALCIUM-DEPENDENT
PROTEIN KINASE
CGD3_920

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 ILE A  95
ILE A 110
PHE A 101
LEU A 130
 None
 0.83A 5fukA-3dfaA:
undetectable
5fukB-3dfaA:
undetectable		 5fukA-3dfaA:
19.53
5fukB-3dfaA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN

(Escherichia
coli) 		PF00005
(ABC_tran)
PF09383
(NIL) 		4 ILE C 207
ILE C 179
ILE C  87
LEU C 171
 None
 0.80A 5fukA-3dhwC:
undetectable
5fukB-3dhwC:
undetectable		 5fukA-3dhwC:
21.90
5fukB-3dhwC:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e73 LANC-LIKE PROTEIN 1

(Homo sapiens) 		PF05147
(LANC_like) 		4 ILE A 104
ILE A 159
THR A 185
ILE A 186
 None
 0.79A 5fukA-3e73A:
undetectable
5fukB-3e73A:
undetectable		 5fukA-3e73A:
19.18
5fukB-3e73A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1v DNA POLYMERASE III
SUBUNIT BETA

(Escherichia
coli) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 ILE A 317
THR A 293
ILE A 292
PHE A 319
 None
 0.81A 5fukA-3f1vA:
undetectable
5fukB-3f1vA:
undetectable		 5fukA-3f1vA:
20.38
5fukB-3f1vA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		4 THR A 579
ILE A 580
SER A 583
PHE A 585
 None
 0.50A 5fukA-3hs0A:
undetectable
5fukB-3hs0A:
undetectable		 5fukA-3hs0A:
17.92
5fukB-3hs0A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Candida
albicans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ILE A 353
ILE A 358
ILE A 151
PHE A  82
 None
 0.81A 5fukA-3hskA:
undetectable
5fukB-3hskA:
undetectable		 5fukA-3hskA:
22.70
5fukB-3hskA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		4 ILE A 221
ILE A 234
SER A 238
PHE A 239
 None
 0.67A 5fukA-3l6aA:
undetectable
5fukB-3l6aA:
undetectable		 5fukA-3l6aA:
19.52
5fukB-3l6aA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgb TEG12

(uncultured soil
bacterium) 		PF00685
(Sulfotransfer_1) 		4 ILE A  26
ILE A 181
ILE A   7
SER A  41
 None
 0.68A 5fukA-3mgbA:
undetectable
5fukB-3mgbA:
undetectable		 5fukA-3mgbA:
24.85
5fukB-3mgbA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nva CTP SYNTHASE

(Sulfolobus
solfataricus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 THR A 409
ILE A 420
PHE A 360
LEU A 423
 None
 0.80A 5fukA-3nvaA:
undetectable
5fukB-3nvaA:
undetectable		 5fukA-3nvaA:
18.78
5fukB-3nvaA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o01 CELL INVASION
PROTEIN SIPD

(Salmonella
enterica) 		PF06511
(IpaD) 		4 THR A 329
ILE A 330
SER A 333
LEU A  87
 None
 0.71A 5fukA-3o01A:
undetectable
5fukB-3o01A:
undetectable		 5fukA-3o01A:
21.22
5fukB-3o01A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pk0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		4 ILE A  18
THR A 145
ILE A 144
SER A 143
 GOL  A 285 ( 3.7A)
PEG  A 265 ( 4.3A)
None
None
 0.80A 5fukA-3pk0A:
undetectable
5fukB-3pk0A:
undetectable		 5fukA-3pk0A:
24.91
5fukB-3pk0A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE

(Salmonella
enterica) 		PF04131
(NanE) 		4 ILE A 147
ILE A 182
ILE A  70
PHE A 104
 None
 0.83A 5fukA-3q58A:
undetectable
5fukB-3q58A:
undetectable		 5fukA-3q58A:
22.48
5fukB-3q58A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qiv SHORT-CHAIN
DEHYDROGENASE OR
3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 ILE A 238
ILE A 179
SER A 143
LEU A 168
 None
 0.82A 5fukA-3qivA:
undetectable
5fukB-3qivA:
undetectable		 5fukA-3qivA:
23.51
5fukB-3qivA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv9 PYRUVATE KINASE 2

(Trypanosoma
cruzi) 		PF00224
(PK)
PF02887
(PK_C) 		4 ILE A 206
THR A  64
ILE A  65
LEU A  83
 None
 0.74A 5fukA-3qv9A:
undetectable
5fukB-3qv9A:
undetectable		 5fukA-3qv9A:
18.85
5fukB-3qv9A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rih SHORT CHAIN
DEHYDROGENASE OR
REDUCTASE

(Mycobacteroides
abscessus) 		PF13561
(adh_short_C2) 		4 ILE A  31
THR A 158
ILE A 157
SER A 156
 None
PG5  A 273 ( 4.2A)
None
PG5  A 273 ( 4.9A)
 0.78A 5fukA-3rihA:
undetectable
5fukB-3rihA:
undetectable		 5fukA-3rihA:
24.21
5fukB-3rihA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE

(Methanocaldococcus
jannaschii) 		no annotation 4 ILE A 184
ILE A  68
ILE A 171
LEU A  65
 None
 0.80A 5fukA-3s4lA:
undetectable
5fukB-3s4lA:
undetectable		 5fukA-3s4lA:
19.85
5fukB-3s4lA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syq G PROTEIN-ACTIVATED
INWARD RECTIFIER
POTASSIUM CHANNEL 2

(Mus musculus) 		PF01007
(IRK) 		4 ILE A 262
ILE A 213
ILE A 294
LEU A 220
 None
 0.76A 5fukA-3syqA:
undetectable
5fukB-3syqA:
undetectable		 5fukA-3syqA:
21.84
5fukB-3syqA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tvi ASPARTOKINASE

(Clostridium
acetobutylicum) 		PF00696
(AA_kinase)
PF01842
(ACT) 		4 ILE A 302
ILE A 354
THR A 298
ILE A 342
 None
 0.82A 5fukA-3tviA:
undetectable
5fukB-3tviA:
undetectable		 5fukA-3tviA:
20.26
5fukB-3tviA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uav PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Bacillus cereus) 		PF01048
(PNP_UDP_1) 		4 ILE A  28
ILE A  86
ILE A 227
PHE A 221
 None
 0.81A 5fukA-3uavA:
undetectable
5fukB-3uavA:
undetectable		 5fukA-3uavA:
21.89
5fukB-3uavA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uze ENVELOPE PROTEIN

(Dengue virus) 		PF02832
(Flavi_glycop_C) 		4 ILE C 378
THR C 353
ILE C 352
LEU C 321
 None
 0.70A 5fukA-3uzeC:
undetectable
5fukB-3uzeC:
undetectable		 5fukA-3uzeC:
20.78
5fukB-3uzeC:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuo NTNHA

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		4 ILE A 618
ILE A 760
SER A 678
LEU A 624
 None
 0.67A 5fukA-3vuoA:
undetectable
5fukB-3vuoA:
undetectable		 5fukA-3vuoA:
12.09
5fukB-3vuoA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj2 CARBOXYLESTERASE

(Ferroplasma
acidiphilum) 		PF07859
(Abhydrolase_3) 		4 ILE A  92
ILE A 111
ILE A  58
LEU A  80
 None
 0.80A 5fukA-3wj2A:
undetectable
5fukB-3wj2A:
undetectable		 5fukA-3wj2A:
21.67
5fukB-3wj2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zto NUCLEOSIDE
DIPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00334
(NDK) 		4 ILE A 135
ILE A   8
PHE A  40
LEU A  77
 None
 0.67A 5fukA-3ztoA:
undetectable
5fukB-3ztoA:
undetectable		 5fukA-3ztoA:
19.49
5fukB-3ztoA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1

(Homo sapiens) 		PF00753
(Lactamase_B)
PF12706
(Lactamase_B_2) 		4 ILE A  58
THR A  77
ILE A  78
LEU A  71
 None
 0.73A 5fukA-3zwfA:
undetectable
5fukB-3zwfA:
undetectable		 5fukA-3zwfA:
18.97
5fukB-3zwfA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3t DNA MISMATCH REPAIR
PROTEIN HSM3

(Saccharomyces
cerevisiae) 		no annotation 4 ILE A  29
THR A  57
ILE A  58
LEU A  13
 None
 0.68A 5fukA-4a3tA:
undetectable
5fukB-4a3tA:
undetectable		 5fukA-4a3tA:
19.19
5fukB-4a3tA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3s ALDEHYDE
DEHYDROGENASE

(Lachnoclostridium
phytofermentans) 		PF00171
(Aldedh) 		4 ILE A 365
ILE A 362
ILE A 298
LEU A 353
 None
 0.76A 5fukA-4c3sA:
undetectable
5fukB-4c3sA:
undetectable		 5fukA-4c3sA:
20.99
5fukB-4c3sA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG

(Homo sapiens) 		PF02854
(MIF4G) 		4 ILE B 405
ILE B 190
SER B 224
LEU B 185
 None
 0.75A 5fukA-4c9bB:
undetectable
5fukB-4c9bB:
undetectable		 5fukA-4c9bB:
20.59
5fukB-4c9bB:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw5 DFNA

(Bacillus
velezensis) 		PF03060
(NMO) 		4 ILE A 364
ILE A 399
ILE A 410
LEU A 403
 None
 0.78A 5fukA-4cw5A:
undetectable
5fukB-4cw5A:
undetectable		 5fukA-4cw5A:
20.43
5fukB-4cw5A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2i HERA

(Sulfolobus
solfataricus) 		PF01935
(DUF87)
PF05872
(DUF853)
PF09378
(HAS-barrel) 		4 ILE A 165
ILE A 186
ILE A 174
LEU A 189
 None
 0.79A 5fukA-4d2iA:
undetectable
5fukB-4d2iA:
undetectable		 5fukA-4d2iA:
19.96
5fukB-4d2iA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		4 ILE A 434
ILE A 372
ILE A 380
PHE A 397
 None
 0.76A 5fukA-4e0tA:
undetectable
5fukB-4e0tA:
undetectable		 5fukA-4e0tA:
20.05
5fukB-4e0tA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE

(Solanum
tuberosum) 		PF00332
(Glyco_hydro_17) 		4 ILE A 253
ILE A 182
SER A 155
LEU A 162
 None
 0.73A 5fukA-4gziA:
undetectable
5fukB-4gziA:
undetectable		 5fukA-4gziA:
22.88
5fukB-4gziA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgn 2-KETO-3-DEOXY-D-MAN
NO-OCTULOSONATE
8-PHOSPHATE
PHOSPHOHYDROLASE

(Bacteroides
thetaiotaomicron) 		PF08282
(Hydrolase_3) 		4 ILE A  47
ILE A  59
PHE A  94
LEU A  75
 None
 0.79A 5fukA-4hgnA:
undetectable
5fukB-4hgnA:
undetectable		 5fukA-4hgnA:
20.90
5fukB-4hgnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hym TOPOISOMERASE IV,
SUBUNIT B

(Francisella
tularensis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 ILE A 306
ILE A 286
ILE A 367
LEU A 315
 None
 0.67A 5fukA-4hymA:
undetectable
5fukB-4hymA:
undetectable		 5fukA-4hymA:
20.41
5fukB-4hymA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mst CLASS I CHITINASE

(Hevea
brasiliensis) 		PF00182
(Glyco_hydro_19) 		4 ILE A 205
ILE A  85
THR A  96
PHE A 110
 None
 0.79A 5fukA-4mstA:
undetectable
5fukB-4mstA:
undetectable		 5fukA-4mstA:
20.44
5fukB-4mstA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opf NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ILE A6469
THR A6408
ILE A6406
LEU A6489
 None
 0.81A 5fukA-4opfA:
undetectable
5fukB-4opfA:
undetectable		 5fukA-4opfA:
21.38
5fukB-4opfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF10294
(Methyltransf_16) 		4 ILE A 247
ILE A 227
ILE A 318
PHE A 280
 None
 0.57A 5fukA-4pwyA:
undetectable
5fukB-4pwyA:
undetectable		 5fukA-4pwyA:
21.83
5fukB-4pwyA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qa8 PUTATIVE LIPOPROTEIN
LPRF

(Mycobacterium
bovis) 		PF07161
(LppX_LprAFG) 		4 ILE A 154
ILE A 197
ILE A 245
LEU A 204
 None
None
PJZ  A 301 ( 4.2A)
None
 0.73A 5fukA-4qa8A:
undetectable
5fukB-4qa8A:
undetectable		 5fukA-4qa8A:
24.07
5fukB-4qa8A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwy TRYPSIN-1

(Homo sapiens) 		PF00089
(Trypsin) 		4 ILE A 106
ILE A  47
THR A 241
ILE A 242
 None
 0.79A 5fukA-4wwyA:
undetectable
5fukB-4wwyA:
undetectable		 5fukA-4wwyA:
21.83
5fukB-4wwyA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		4 ILE A 119
ILE A 144
ILE A 181
LEU A 208
 None
 0.81A 5fukA-4xfwA:
undetectable
5fukB-4xfwA:
undetectable		 5fukA-4xfwA:
23.32
5fukB-4xfwA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xng UNCHARACTERIZED
PROTEIN MG218.1

(Mycoplasma
genitalium) 		no annotation 4 ILE A 179
THR A 131
ILE A 135
PHE A  81
 None
 0.82A 5fukA-4xngA:
undetectable
5fukB-4xngA:
undetectable		 5fukA-4xngA:
23.81
5fukB-4xngA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8n RETICULOCYTE-BINDING
PROTEIN 2A

(Plasmodium
vivax) 		no annotation 4 ILE A 174
ILE A 382
THR A 429
LEU A 424
 None
 0.74A 5fukA-4z8nA:
undetectable
5fukB-4z8nA:
undetectable		 5fukA-4z8nA:
20.56
5fukB-4z8nA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkq PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cricetid
gammaherpesvirus
2) 		no annotation 4 ILE A 217
THR A  80
ILE A  79
LEU A 221
 None
 0.81A 5fukA-4zkqA:
undetectable
5fukB-4zkqA:
undetectable		 5fukA-4zkqA:
18.52
5fukB-4zkqA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC

(Chlamydomonas
reinhardtii) 		no annotation 4 ILE A 180
ILE A 314
PHE A  85
LEU A 118
 None
 0.72A 5fukA-5b5xA:
undetectable
5fukB-5b5xA:
undetectable		 5fukA-5b5xA:
21.22
5fukB-5b5xA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdh MAJOR ACID
PHOSPHATASE

(Legionella
pneumophila) 		PF00328
(His_Phos_2) 		4 ILE A 194
THR A 228
ILE A 229
SER A 232
 None
None
None
1PE  A 402 (-3.4A)
 0.76A 5fukA-5cdhA:
undetectable
5fukB-5cdhA:
undetectable		 5fukA-5cdhA:
21.35
5fukB-5cdhA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9n B-1,4-ENDOGLUCANASE

(Prevotella
bryantii) 		PF00150
(Cellulase) 		5 ILE A 263
THR A 321
ILE A 278
SER A 319
LEU A 260
 XYS  A 410 ( 4.7A)
None
None
None
None
 1.15A 5fukA-5d9nA:
undetectable
5fukB-5d9nA:
undetectable		 5fukA-5d9nA:
22.78
5fukB-5d9nA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0q NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96

(Xenopus
tropicalis) 		PF04096
(Nucleoporin2) 		4 ILE B 777
THR B 729
ILE B 753
LEU B 772
 None
 0.83A 5fukA-5e0qB:
undetectable
5fukB-5e0qB:
undetectable		 5fukA-5e0qB:
19.67
5fukB-5e0qB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfohalobium
retbaense) 		PF13458
(Peripla_BP_6) 		4 ILE A 467
ILE A 579
ILE A 496
LEU A 588
 None
 0.81A 5fukA-5ereA:
undetectable
5fukB-5ereA:
undetectable		 5fukA-5ereA:
19.00
5fukB-5ereA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG

(Caenorhabditis
elegans) 		PF03159
(XRN_N) 		4 ILE A 192
ILE A 179
ILE A  85
LEU A 196
 None
 0.77A 5fukA-5firA:
undetectable
5fukB-5firA:
undetectable		 5fukA-5firA:
16.30
5fukB-5firA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ILE B  52
ILE B  73
THR B  45
ILE B 143
 None
 0.74A 5fukA-5fq6B:
undetectable
5fukB-5fq6B:
undetectable		 5fukA-5fq6B:
12.94
5fukB-5fq6B:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]

(Thermotoga
maritima) 		PF03060
(NMO) 		4 ILE A 173
ILE A 293
ILE A 284
SER A 280
 None
None
None
FMN  A 402 (-2.7A)
 0.77A 5fukA-5gvhA:
undetectable
5fukB-5gvhA:
undetectable		 5fukA-5gvhA:
24.38
5fukB-5gvhA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1k GEM-ASSOCIATED
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ILE A 550
ILE A 584
THR A 573
ILE A 574
 None
 0.72A 5fukA-5h1kA:
undetectable
5fukB-5h1kA:
undetectable		 5fukA-5h1kA:
15.86
5fukB-5h1kA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcf CALRETICULIN,
PUTATIVE,CALRETICULI
N, PUTATIVE

(Trypanosoma
cruzi) 		PF00262
(Calreticulin) 		4 ILE A 317
THR A  68
SER A 324
LEU A  76
 None
 0.82A 5fukA-5hcfA:
undetectable
5fukB-5hcfA:
undetectable		 5fukA-5hcfA:
20.86
5fukB-5hcfA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk7 URACIL-DNA
GLYCOSYLASE

(Homo sapiens) 		PF03167
(UDG) 		4 ILE D 141
ILE D 173
SER D 169
LEU D 202
 None
 0.71A 5fukA-5jk7D:
undetectable
5fukB-5jk7D:
undetectable		 5fukA-5jk7D:
19.44
5fukB-5jk7D:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk5 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Acidaminococcus
sp. BV3L6) 		no annotation 4 ILE A 374
THR A 439
ILE A 442
LEU A 481
 None
 0.80A 5fukA-5kk5A:
undetectable
5fukB-5kk5A:
undetectable		 5fukA-5kk5A:
10.96
5fukB-5kk5A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljm SPERMATOGENESIS-ASSO
CIATED PROTEIN 2

(Homo sapiens) 		no annotation 4 ILE A 134
THR A 125
SER A  73
LEU A  92
 None
GOL  A 302 ( 4.9A)
None
None
 0.76A 5fukA-5ljmA:
undetectable
5fukB-5ljmA:
undetectable		 5fukA-5ljmA:
17.09
5fukB-5ljmA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me3 SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		4 ILE A 706
ILE A 713
THR A 728
ILE A 729
 None
 0.70A 5fukA-5me3A:
undetectable
5fukB-5me3A:
undetectable		 5fukA-5me3A:
12.18
5fukB-5me3A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu5 UNCHARACTERIZED
PROTEIN

(Magnetospirillum
magneticum) 		no annotation 4 ILE A 199
ILE A 147
PHE A 228
LEU A 180
 None
 0.76A 5fukA-5mu5A:
undetectable
5fukB-5mu5A:
undetectable		 5fukA-5mu5A:
18.26
5fukB-5mu5A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ore OCTOPINE-BINDING
PERIPLASMIC PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 4 ILE A  50
THR A  26
ILE A  27
LEU A  45
 None
 0.81A 5fukA-5oreA:
undetectable
5fukB-5oreA:
undetectable		 5fukA-5oreA:
16.02
5fukB-5oreA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE

(Brucella
abortus) 		PF13561
(adh_short_C2) 		4 ILE A 220
ILE A 135
THR A  13
PHE A  27
 None
 0.82A 5fukA-5t5qA:
undetectable
5fukB-5t5qA:
undetectable		 5fukA-5t5qA:
27.11
5fukB-5t5qA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tey N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14

(Homo sapiens) 		PF05063
(MT-A70) 		4 ILE A 456
ILE B 315
THR A 460
ILE A 466
 None
 0.65A 5fukA-5teyA:
undetectable
5fukB-5teyA:
undetectable		 5fukA-5teyA:
17.54
5fukB-5teyA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vis DIHYDROPTEROATE
SYNTHASE

(soil metagenome) 		PF00809
(Pterin_bind) 		4 ILE A   6
THR A 233
ILE A 234
SER A 237
 None
 0.62A 5fukA-5visA:
undetectable
5fukB-5visA:
undetectable		 5fukA-5visA:
21.84
5fukB-5visA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6an7 TRANSPORT PERMEASE
PROTEIN

(Aquifex
aeolicus) 		no annotation 4 ILE D  81
ILE D 108
ILE D 148
SER D 151
 None
 0.81A 5fukA-6an7D:
undetectable
5fukB-6an7D:
undetectable		 5fukA-6an7D:
23.13
5fukB-6an7D:
23.13