SIMILAR PATTERNS OF AMINO ACIDS FOR 5FSE_C_HQEC1583_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE

(Escherichia
coli) 		PF00218
(IGPS)
PF00697
(PRAI) 		4 ILE A  73
ARG A  65
CYH A  54
GLU A  53
 None
 1.43A 5fseC-1piiA:
1.3		 5fseC-1piiA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf8 CASEIN KINASE II

(Homo sapiens) 		PF01214
(CK_II_beta) 		4 ILE A  88
GLN A  96
CYH A  23
GLU A  24
 None
 1.18A 5fseC-1qf8A:
undetectable		 5fseC-1qf8A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II

(Homo sapiens) 		PF00106
(adh_short) 		4 ILE A 189
GLN A 138
ARG A 147
GLU A 135
 None
 1.33A 5fseC-1so8A:
3.1		 5fseC-1so8A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 ILE A  95
GLN A  42
ARG A  41
GLU A  39
 None
 1.48A 5fseC-2d3tA:
2.4		 5fseC-2d3tA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Thermus
caldophilus) 		PF01116
(F_bP_aldolase) 		4 ILE A 228
GLN A 215
ARG A 222
GLU A 216
 None
 1.45A 5fseC-2fjkA:
2.6		 5fseC-2fjkA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n12 UNCONVENTIONAL
MYOSIN-VI

(Homo sapiens) 		no annotation 4 ILE A 106
ARG A 119
CYH A 118
GLU A 121
 None
 1.43A 5fseC-2n12A:
undetectable		 5fseC-2n12A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2noz N-GLYCOSYLASE/DNA
LYASE

(Homo sapiens) 		PF00730
(HhH-GPD)
PF07934
(OGG_N) 		4 ILE A 254
GLN A 135
CYH A 140
GLU A 139
 None
 0.96A 5fseC-2nozA:
0.0		 5fseC-2nozA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3v MEVALONATE KINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ILE A 119
GLN A 123
CYH A 161
GLU A 162
 None
 1.40A 5fseC-2r3vA:
undetectable		 5fseC-2r3vA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR

(Pseudomonas
putida) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		4 GLN A 128
ARG A 127
CYH A 124
GLU A 125
 None
 1.39A 5fseC-2uxoA:
undetectable		 5fseC-2uxoA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4t DNAJ HOMOLOG
SUBFAMILY C MEMBER 3

(Homo sapiens) 		PF00226
(DnaJ)
PF09976
(TPR_21)
PF13181
(TPR_8) 		4 ILE A 174
ARG A 194
CYH A 197
GLU A 196
 None
 1.08A 5fseC-2y4tA:
0.0		 5fseC-2y4tA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fh2 PROBABLE
ATP-DEPENDENT
PROTEASE (HEAT SHOCK
PROTEIN)

(Corynebacterium
glutamicum) 		PF02861
(Clp_N) 		4 ILE A  38
GLN A  61
ARG A  60
GLU A  62
 None
 1.31A 5fseC-3fh2A:
undetectable		 5fseC-3fh2A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fky GLUTAMINE SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 ILE A 339
GLN A 132
CYH A 249
GLU A 133
 None
None
None
FLC  A 371 (-3.2A)
 1.27A 5fseC-3fkyA:
0.0		 5fseC-3fkyA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd PROTEIN DIN1

(Schizosaccharomyces
pombe) 		PF08652
(RAI1) 		4 ILE B 167
ARG B 170
CYH B 162
GLU B 157
 None
 1.39A 5fseC-3fqdB:
undetectable		 5fseC-3fqdB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbx GLUTAMATE
DECARBOXYLASE 1

(Arabidopsis
thaliana) 		PF00282
(Pyridoxal_deC) 		4 ILE A  76
GLN A 331
CYH A  72
GLU A  69
 None
 1.31A 5fseC-3hbxA:
undetectable		 5fseC-3hbxA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ieg DNAJ HOMOLOG
SUBFAMILY C MEMBER 3

(Mus musculus) 		PF09976
(TPR_21)
PF13181
(TPR_8) 		4 ILE A 174
ARG A 194
CYH A 197
GLU A 196
 None
 1.33A 5fseC-3iegA:
undetectable		 5fseC-3iegA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 ILE A 194
GLN A 269
CYH A 213
GLU A 214
 ANP  A   1 (-4.8A)
None
ANP  A   1 (-4.3A)
None
 1.47A 5fseC-3is5A:
undetectable		 5fseC-3is5A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lke ENOYL-COA HYDRATASE

(Bacillus
halodurans) 		PF00378
(ECH_1) 		4 ILE A 127
ARG A 196
CYH A 187
GLU A 188
 None
 1.01A 5fseC-3lkeA:
2.6		 5fseC-3lkeA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		4 GLN A 302
ARG A 268
CYH A 262
GLU A 263
 None
 1.27A 5fseC-3nz4A:
undetectable		 5fseC-3nz4A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4t TPR
REPEAT-CONTAINING
PROTEIN

(Cytophaga
hutchinsonii) 		PF07719
(TPR_2) 		4 ILE A 248
ARG A 268
CYH A 271
GLU A 274
 None
 1.19A 5fseC-3u4tA:
undetectable		 5fseC-3u4tA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2

(Escherichia
coli) 		PF00294
(PfkB) 		4 ILE A 136
GLN A 157
CYH A 163
GLU A 182
 None
 1.47A 5fseC-3uqeA:
2.3		 5fseC-3uqeA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v6a APOPTOSIS INHIBITOR
5

(Homo sapiens) 		PF05918
(API5) 		4 ILE A  78
GLN A  47
ARG A  43
GLU A  85
 None
 1.48A 5fseC-3v6aA:
undetectable		 5fseC-3v6aA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Tetrahymena
thermophila) 		PF05028
(PARG_cat) 		4 ILE A 161
GLN A 166
ARG A 165
GLU A 167
 None
 1.07A 5fseC-4eppA:
2.6		 5fseC-4eppA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hc5 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Sphaerobacter
thermophilus) 		PF00903
(Glyoxalase) 		4 ILE A  87
GLN A 112
ARG A 113
GLU A 130
 None
 1.29A 5fseC-4hc5A:
undetectable		 5fseC-4hc5A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hrt GLOBIN-2 A CHAIN
HEMOGLOBIN B CHAIN

(Scapharca
inaequivalvis) 		PF00042
(Globin) 		4 ILE B  73
ARG A  89
CYH A  92
GLU A  95
 None
 1.33A 5fseC-4hrtB:
undetectable		 5fseC-4hrtB:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		4 ILE A 335
ARG A 342
CYH A 345
GLU A 348
 None
 1.42A 5fseC-4hsuA:
undetectable		 5fseC-4hsuA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcs ENOYL-COA
HYDRATASE/ISOMERASE

(Cupriavidus
metallidurans) 		PF00378
(ECH_1) 		4 ILE A 195
GLN A 190
ARG A 191
GLU A 189
 None
 1.03A 5fseC-4jcsA:
1.6		 5fseC-4jcsA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01746
(tRNA_m1G_MT) 		4 ILE A 112
GLN A 146
ARG A 143
GLU A 149
 None
 1.50A 5fseC-4jwjA:
undetectable		 5fseC-4jwjA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh1 CASEIN KINASE II
SUBUNIT BETA

(Homo sapiens) 		PF01214
(CK_II_beta) 		4 ILE C  88
GLN C  96
CYH C  23
GLU C  24
 None
 1.28A 5fseC-4nh1C:
undetectable		 5fseC-4nh1C:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5y GLYCOSYL HYDROLASE,
FAMILY
31/FIBRONECTIN TYPE
III DOMAIN PROTEIN

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		4 ILE A  46
GLN A  80
ARG A  79
GLU A  43
 None
None
NGA  A 201 (-2.3A)
None
 1.21A 5fseC-4p5yA:
undetectable		 5fseC-4p5yA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6

(Saccharomyces
cerevisiae) 		PF09295
(ChAPs) 		4 ILE B  78
ARG B  58
CYH B  54
GLU B  53
 None
 1.29A 5fseC-4yg8B:
2.1		 5fseC-4yg8B:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo4 DEPHOSPHO-COA KINASE

(Campylobacter
jejuni) 		PF01121
(CoaE) 		4 ILE A  21
ARG A 186
CYH A 189
GLU A 188
 None
 1.21A 5fseC-4zo4A:
undetectable		 5fseC-4zo4A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5che PROTEIN FLUORESCENT
IN BLUE LIGHT,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13424
(TPR_12) 		4 ILE E 264
GLN E 255
CYH E 293
GLU E 296
 None
 1.46A 5fseC-5cheE:
undetectable		 5fseC-5cheE:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csc CITRATE SYNTHASE

(Gallus gallus) 		PF00285
(Citrate_synt) 		4 ILE B 234
ARG B 329
CYH B 332
GLU B 335
 None
 1.27A 5fseC-5cscB:
undetectable		 5fseC-5cscB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csc CITRATE SYNTHASE

(Gallus gallus) 		PF00285
(Citrate_synt) 		4 ILE B 234
GLN B  75
CYH B 332
GLU B 335
 None
 1.47A 5fseC-5cscB:
undetectable		 5fseC-5cscB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN

(Klebsiella
pneumoniae) 		PF13407
(Peripla_BP_4) 		4 ILE A 245
GLN A 242
ARG A 241
GLU A 237
 None
 1.36A 5fseC-5hsgA:
2.2		 5fseC-5hsgA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		4 ILE A 322
GLN A 329
ARG A 332
GLU A 144
 None
 1.34A 5fseC-5mq6A:
undetectable		 5fseC-5mq6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Homo sapiens) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 ILE A 234
GLN A 372
ARG A 370
CYH A 232
 None
 1.34A 5fseC-5ukwA:
1.3		 5fseC-5ukwA:
21.41