SIMILAR PATTERNS OF AMINO ACIDS FOR 5FSA_B_X2NB590_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bf2 | ISOAMYLASE (Pseudomonasamyloderamosa) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 3 | PRO A 499LEU A 643SER A 635 | None | 0.80A | 5fsaB-1bf2A:0.0 | 5fsaB-1bf2A:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fsk | ANTIBODY HEAVY CHAINFAB (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 3 | PRO C 86LEU C 11SER C 17 | None | 0.55A | 5fsaB-1fskC:0.0 | 5fsaB-1fskC:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iu1 | GAMMA1-ADAPTIN (Homo sapiens) |
PF02883(Alpha_adaptinC2) | 3 | PRO A 765LEU A 798SER A 768 | None | 0.78A | 5fsaB-1iu1A:undetectable | 5fsaB-1iu1A:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iyb | RIBONUCLEASE (Nicotianaglutinosa) |
PF00445(Ribonuclease_T2) | 3 | PRO A 14LEU A 123SER A 34 | None | 0.62A | 5fsaB-1iybA:0.0 | 5fsaB-1iybA:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iyb | RIBONUCLEASE (Nicotianaglutinosa) |
PF00445(Ribonuclease_T2) | 3 | PRO A 14LEU A 127SER A 34 | None | 0.77A | 5fsaB-1iybA:0.0 | 5fsaB-1iybA:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jeq | KU70 (Homo sapiens) |
PF02037(SAP)PF02735(Ku)PF03730(Ku_C)PF03731(Ku_N) | 3 | PRO A 370LEU A 413SER A 383 | None | 0.72A | 5fsaB-1jeqA:0.0 | 5fsaB-1jeqA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jy5 | CALSEPRRP (Calystegiasepium) |
PF00445(Ribonuclease_T2) | 3 | PRO A 199LEU A 204SER A 172 | None | 0.72A | 5fsaB-1jy5A:0.0 | 5fsaB-1jy5A:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lzk | HEROIN ESTERASE (Rhodococcus sp.) |
PF07859(Abhydrolase_3) | 3 | PRO A 180LEU A 83SER A 152 | None | 0.84A | 5fsaB-1lzkA:0.0 | 5fsaB-1lzkA:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mh6 | BLEOMYCIN RESISTANCEPROTEIN (Klebsiellapneumoniae) |
no annotation | 3 | PRO A 309LEU A 245SER A 216 | None | 0.73A | 5fsaB-1mh6A:undetectable | 5fsaB-1mh6A:13.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n9b | BETA-LACTAMASE SHV-2 (Klebsiellapneumoniae) |
PF13354(Beta-lactamase2) | 3 | PRO A 107LEU A 122SER A 130 | NoneNoneEPE A 400 (-2.5A) | 0.78A | 5fsaB-1n9bA:0.0 | 5fsaB-1n9bA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ocm | MALONAMIDASE E2 (Bradyrhizobiumjaponicum) |
PF01425(Amidase) | 3 | PRO A 115LEU A 119SER A 355 | None | 0.84A | 5fsaB-1ocmA:undetectable | 5fsaB-1ocmA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1on9 | METHYLMALONYL-COACARBOXYLTRANSFERASE12S SUBUNIT (Propionibacteriumfreudenreichii) |
PF01039(Carboxyl_trans) | 3 | PRO A 372LEU A 317SER A 340 | None | 0.58A | 5fsaB-1on9A:undetectable | 5fsaB-1on9A:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q47 | SEMAPHORIN 3A (Mus musculus) |
PF01403(Sema) | 3 | PRO A 415LEU A 308SER A 294 | None | 0.67A | 5fsaB-1q47A:undetectable | 5fsaB-1q47A:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t6p | PHENYLALANINEAMMONIA-LYASE (Rhodotorulatoruloides) |
PF00221(Lyase_aromatic) | 3 | PRO A 369LEU A 335SER A 310 | None | 0.82A | 5fsaB-1t6pA:1.5 | 5fsaB-1t6pA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vqv | THIAMINEMONOPHOSPHATE KINASE (Aquifexaeolicus) |
PF00586(AIRS) | 3 | PRO A 57LEU A 86SER A 95 | None | 0.75A | 5fsaB-1vqvA:undetectable | 5fsaB-1vqvA:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1we5 | PUTATIVE FAMILY 31GLUCOSIDASE YICI (Escherichiacoli) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 3 | PRO A 678LEU A 340SER A 268 | None | 0.73A | 5fsaB-1we5A:undetectable | 5fsaB-1we5A:21.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1x8v | CYTOCHROME P450 51 (Mycobacteriumtuberculosis) |
PF00067(p450) | 3 | PRO A 178LEU A 29SER A 431 | None | 0.77A | 5fsaB-1x8vA:34.6 | 5fsaB-1x8vA:30.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aey | FRUCTAN1-EXOHYDROLASE IIA (Cichoriumintybus) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 3 | PRO A 253LEU A 266SER A 258 | None | 0.57A | 5fsaB-2aeyA:undetectable | 5fsaB-2aeyA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b5y | YKUV PROTEIN (Bacillussubtilis) |
PF00578(AhpC-TSA) | 3 | PRO A 70LEU A 17SER A 98 | None | 0.80A | 5fsaB-2b5yA:undetectable | 5fsaB-2b5yA:14.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dhz | RAP GUANINENUCLEOTIDE EXCHANGEFACTOR (GEF)-LIKE 1 (Homo sapiens) |
no annotation | 3 | PRO A 17LEU A 58SER A 94 | None | 0.82A | 5fsaB-2dhzA:undetectable | 5fsaB-2dhzA:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2djk | PROTEINDISULFIDE-ISOMERASE (Humicolainsolens) |
PF13848(Thioredoxin_6) | 3 | PRO A 120LEU A 72SER A 124 | None | 0.85A | 5fsaB-2djkA:undetectable | 5fsaB-2djkA:16.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e9x | DNA REPLICATIONCOMPLEX GINS PROTEINPSF2 (Homo sapiens) |
PF05916(Sld5) | 3 | PRO B 19LEU B 33SER B 22 | None | 0.79A | 5fsaB-2e9xB:undetectable | 5fsaB-2e9xB:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fge | ZINC METALLOPROTEASE(INSULINASE FAMILY) (Arabidopsisthaliana) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C)PF08367(M16C_assoc) | 3 | PRO A 287LEU A 189SER A 183 | None | 0.82A | 5fsaB-2fgeA:undetectable | 5fsaB-2fgeA:19.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hk0 | D-PSICOSE3-EPIMERASE (Agrobacteriumtumefaciens) |
PF01261(AP_endonuc_2) | 3 | PRO A 68LEU A 147SER A 110 | PRO A 68 ( 1.1A)LEU A 147 ( 0.6A)SER A 110 ( 0.0A) | 0.65A | 5fsaB-2hk0A:undetectable | 5fsaB-2hk0A:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2l3u | YBBR FAMILY PROTEIN (Desulfitobacteriumhafniense) |
no annotation | 3 | PRO A 78LEU A 24SER A 28 | None | 0.76A | 5fsaB-2l3uA:undetectable | 5fsaB-2l3uA:12.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ood | BLR3880 PROTEIN (Bradyrhizobiumdiazoefficiens) |
PF01979(Amidohydro_1) | 3 | PRO A 374LEU A 409SER A 439 | None | 0.76A | 5fsaB-2oodA:undetectable | 5fsaB-2oodA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oq3 | MANNITOL-SPECIFICCRYPTICPHOSPHOTRANSFERASEENZYME IIA COMPONENT (Escherichiacoli) |
PF00359(PTS_EIIA_2) | 3 | PRO A 8LEU A 103SER A 31 | None | 0.81A | 5fsaB-2oq3A:undetectable | 5fsaB-2oq3A:16.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qnk | 3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE (Homo sapiens) |
PF06052(3-HAO) | 3 | PRO A 86LEU A 172SER A 176 | None | 0.76A | 5fsaB-2qnkA:undetectable | 5fsaB-2qnkA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vak | SIGMA A (Avianorthoreovirus) |
PF03084(Sigma_1_2) | 3 | PRO A 86LEU A 80SER A 20 | None | 0.68A | 5fsaB-2vakA:undetectable | 5fsaB-2vakA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xij | METHYLMALONYL-COAMUTASE,MITOCHONDRIAL (Homo sapiens) |
PF01642(MM_CoA_mutase)PF02310(B12-binding) | 3 | PRO A 339LEU A 305SER A 342 | None | 0.84A | 5fsaB-2xijA:undetectable | 5fsaB-2xijA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yv5 | YJEQ PROTEIN (Aquifexaeolicus) |
PF03193(RsgA_GTPase) | 3 | PRO A 92LEU A 99SER A 174 | NoneNoneGDP A1001 ( 4.1A) | 0.85A | 5fsaB-2yv5A:undetectable | 5fsaB-2yv5A:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ak5 | HEMOGLOBIN-BINDINGPROTEASE HBP (Escherichiacoli) |
PF02395(Peptidase_S6) | 3 | PRO A 661LEU A 752SER A 689 | None | 0.74A | 5fsaB-3ak5A:undetectable | 5fsaB-3ak5A:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ay5 | CYCLIN-D1-BINDINGPROTEIN 1 (Homo sapiens) |
PF13324(GCIP) | 3 | PRO A 17LEU A 77SER A 81 | None | 0.69A | 5fsaB-3ay5A:undetectable | 5fsaB-3ay5A:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3btp | SINGLE-STRANDDNA-BINDING PROTEIN (Agrobacteriumfabrum) |
PF07229(VirE2) | 3 | PRO A 161LEU A 264SER A 258 | None | 0.78A | 5fsaB-3btpA:undetectable | 5fsaB-3btpA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d3l | ARACHIDONATE12-LIPOXYGENASE,12S-TYPE (Homo sapiens) |
PF00305(Lipoxygenase) | 3 | PRO A 558LEU A 296SER A 345 | None | 0.60A | 5fsaB-3d3lA:1.9 | 5fsaB-3d3lA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eay | SENTRIN-SPECIFICPROTEASE 7 (Homo sapiens) |
PF02902(Peptidase_C48) | 3 | PRO A 788LEU A 722SER A 739 | None | 0.82A | 5fsaB-3eayA:undetectable | 5fsaB-3eayA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fle | SE_1780 PROTEIN (Staphylococcusepidermidis) |
PF06028(DUF915) | 3 | PRO A 164LEU A 94SER A 127 | None | 0.82A | 5fsaB-3fleA:undetectable | 5fsaB-3fleA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fm0 | PROTEIN CIAO1 (Homo sapiens) |
PF00400(WD40) | 3 | PRO A 160LEU A 263SER A 205 | None | 0.78A | 5fsaB-3fm0A:undetectable | 5fsaB-3fm0A:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hjb | GLUCOSE-6-PHOSPHATEISOMERASE (Vibrio cholerae) |
PF00342(PGI) | 3 | PRO A 407LEU A 170SER A 410 | None | 0.80A | 5fsaB-3hjbA:undetectable | 5fsaB-3hjbA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i9v | NADH-QUINONEOXIDOREDUCTASESUBUNIT 3 (Thermusthermophilus) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4)PF10588(NADH-G_4Fe-4S_3)PF13510(Fer2_4) | 3 | PRO 3 551LEU 3 345SER 3 557 | None | 0.74A | 5fsaB-3i9v3:undetectable | 5fsaB-3i9v3:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k1j | ATP-DEPENDENTPROTEASE LON (Thermococcusonnurineus) |
PF01078(Mg_chelatase)PF05362(Lon_C)PF13654(AAA_32) | 3 | PRO A 581LEU A 446SER A 550 | None | 0.68A | 5fsaB-3k1jA:undetectable | 5fsaB-3k1jA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mwb | PREPHENATEDEHYDRATASE (Paenarthrobacteraurescens) |
PF00800(PDT)PF01842(ACT) | 3 | PRO A 191LEU A 183SER A 276 | None | 0.82A | 5fsaB-3mwbA:undetectable | 5fsaB-3mwbA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3myr | NICKEL-DEPENDENTHYDROGENASE LARGESUBUNIT (Allochromatiumvinosum) |
PF00374(NiFeSe_Hases) | 3 | PRO B1225LEU B1228SER B1232 | None | 0.81A | 5fsaB-3myrB:1.0 | 5fsaB-3myrB:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ol2 | SEMAPHORIN-4D (Homo sapiens) |
PF00047(ig)PF01403(Sema)PF01437(PSI) | 3 | PRO A 406LEU A 293SER A 282 | None | 0.76A | 5fsaB-3ol2A:undetectable | 5fsaB-3ol2A:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pb9 | GLUTAMINYL-PEPTIDECYCLOTRANSFERASE-LIKE PROTEIN (Homo sapiens) |
PF04389(Peptidase_M28) | 3 | PRO X 320LEU X 339SER X 323 | None | 0.61A | 5fsaB-3pb9X:undetectable | 5fsaB-3pb9X:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w0l | GLUCOKINASEREGULATORY PROTEIN (Xenopus laevis) |
no annotation | 3 | PRO B 453LEU B 406SER B 430 | None | 0.81A | 5fsaB-3w0lB:0.4 | 5fsaB-3w0lB:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3whe | HEMAGGLUTININ (Influenza Avirus) |
PF00509(Hemagglutinin) | 3 | PRO A 215LEU A 194SER A 199 | None | 0.74A | 5fsaB-3wheA:undetectable | 5fsaB-3wheA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ag4 | MONOCLONAL ANTIBODY3E3 HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 3 | PRO H 82LEU H 11SER H 17 | None | 0.75A | 5fsaB-4ag4H:undetectable | 5fsaB-4ag4H:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b5q | GLYCOSIDE HYDROLASEFAMILY 61 PROTEIN D (Phanerochaetechrysosporium) |
PF03443(Glyco_hydro_61) | 3 | PRO A 10LEU A 141SER A 61 | None | 0.81A | 5fsaB-4b5qA:undetectable | 5fsaB-4b5qA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4blf | SINGLE-STRANDDNA-BINDING PROTEIN (Agrobacteriumtumefaciens) |
PF07229(VirE2) | 3 | PRO A 161LEU A 264SER A 258 | None | 0.79A | 5fsaB-4blfA:undetectable | 5fsaB-4blfA:18.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cak | INTEGRIN BETA-3 (Homo sapiens) |
PF00362(Integrin_beta)PF07965(Integrin_B_tail)PF07974(EGF_2)PF17205(PSI_integrin) | 3 | PRO B 363LEU B 92SER B 413 | None | 0.76A | 5fsaB-4cakB:undetectable | 5fsaB-4cakB:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fhn | NUCLEOPORIN NUP120 (Schizosaccharomycespombe) |
PF11715(Nup160) | 3 | PRO B 96LEU B 673SER B 92 | None | 0.79A | 5fsaB-4fhnB:undetectable | 5fsaB-4fhnB:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gbr | BETA-2 ADRENERGICRECEPTOR (Homo sapiens) |
PF00001(7tm_1) | 3 | PRO A 211LEU A 259SER A 207 | NoneNoneCAU A 500 (-4.1A) | 0.82A | 5fsaB-4gbrA:0.0 | 5fsaB-4gbrA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gq1 | NUP37 (Schizosaccharomycespombe) |
PF00400(WD40) | 3 | PRO A 195LEU A 283SER A 264 | None | 0.83A | 5fsaB-4gq1A:undetectable | 5fsaB-4gq1A:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gz8 | SEMAPHORIN-3A (Mus musculus) |
PF01403(Sema) | 3 | PRO A 415LEU A 308SER A 294 | None | 0.70A | 5fsaB-4gz8A:undetectable | 5fsaB-4gz8A:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hmw | PYRIDOXAMINE5'-PHOSPHATE OXIDASE (Burkholderialata) |
PF01243(Putative_PNPOx)PF10590(PNP_phzG_C) | 3 | PRO A 169LEU A 162SER A 137 | None | 0.68A | 5fsaB-4hmwA:undetectable | 5fsaB-4hmwA:18.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kys | THIAMINEPYRIDINYLASE I (Clostridiumbotulinum) |
PF01547(SBP_bac_1) | 3 | PRO A 246LEU A 186SER A 251 | None | 0.54A | 5fsaB-4kysA:undetectable | 5fsaB-4kysA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l15 | FIDGETIN-LIKEPROTEIN 1 (Caenorhabditiselegans) |
PF00004(AAA)PF09336(Vps4_C) | 3 | PRO A 357LEU A 321SER A 519 | None | 0.70A | 5fsaB-4l15A:undetectable | 5fsaB-4l15A:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ld7 | DIMETHYLALLYLTRYPTOPHAN SYNTHASE (Aspergillusfischeri) |
PF11991(Trp_DMAT) | 3 | PRO A 243LEU A 281SER A 346 | None | 0.72A | 5fsaB-4ld7A:undetectable | 5fsaB-4ld7A:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lg9 | F-BOX-LIKE/WDREPEAT-CONTAININGPROTEIN TBL1XR1 (Homo sapiens) |
PF00400(WD40) | 3 | PRO A 179LEU A 231SER A 235 | None | 0.77A | 5fsaB-4lg9A:undetectable | 5fsaB-4lg9A:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n2r | ALPHA-L-ARABINOFURANOSIDASE UMABF62A (Ustilago maydis) |
PF03664(Glyco_hydro_62) | 3 | PRO A 41LEU A 283SER A 267 | None | 0.81A | 5fsaB-4n2rA:undetectable | 5fsaB-4n2rA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r5o | QUINONPROTEINALCOHOLDEHYDROGENASE-LIKEPROTEIN (Bacteroidesthetaiotaomicron) |
PF16819(DUF5074)PF16820(PKD_3) | 3 | PRO A 348LEU A 398SER A 442 | None | 0.71A | 5fsaB-4r5oA:undetectable | 5fsaB-4r5oA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ufc | GH95 (Bacteroidesovatus) |
PF14498(Glyco_hyd_65N_2) | 3 | PRO A 188LEU A 59SER A 360 | None | 0.72A | 5fsaB-4ufcA:undetectable | 5fsaB-4ufcA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w6z | ALCOHOLDEHYDROGENASE 1 (Saccharomycescerevisiae) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | PRO A 271LEU A 182SER A 248 | None8ID A 403 (-3.3A)8ID A 403 (-3.5A) | 0.78A | 5fsaB-4w6zA:undetectable | 5fsaB-4w6zA:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wj3 | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT A (Pseudomonasaeruginosa) |
PF01425(Amidase) | 3 | PRO A 180LEU A 120SER A 176 | None | 0.83A | 5fsaB-4wj3A:1.1 | 5fsaB-4wj3A:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xk1 | PHOSPHOSERINEAMINOTRANSFERASE (Pseudomonasaeruginosa) |
PF00266(Aminotran_5) | 3 | PRO A 132LEU A 139SER A 122 | None | 0.74A | 5fsaB-4xk1A:undetectable | 5fsaB-4xk1A:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yra | L-THREONINE3-DEHYDROGENASE,MITOCHONDRIAL (Mus musculus) |
PF01370(Epimerase) | 3 | PRO A 223LEU A 355SER A 294 | None | 0.82A | 5fsaB-4yraA:undetectable | 5fsaB-4yraA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zyl | RPHYB PROTEIN (Rhodopseudomonaspalustris) |
PF00072(Response_reg) | 3 | PRO A 8LEU A 136SER A 33 | None | 0.78A | 5fsaB-4zylA:undetectable | 5fsaB-4zylA:16.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a20 | MAJOR TAIL PROTEINGP17.1 (Bacillus phageSPP1) |
PF06199(Phage_tail_2) | 3 | PRO H 147LEU H 43SER H 58 | None | 0.44A | 5fsaB-5a20H:undetectable | 5fsaB-5a20H:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a3f | DYNAMIN 3 (Homo sapiens) |
PF00169(PH)PF00350(Dynamin_N)PF01031(Dynamin_M)PF02212(GED) | 3 | PRO A 68LEU A 29SER A 117 | None | 0.77A | 5fsaB-5a3fA:0.1 | 5fsaB-5a3fA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dqp | EDTA MONOOXYGENASE (EDTA-degradingbacterium BNC1) |
PF00296(Bac_luciferase) | 3 | PRO A 59LEU A 55SER A 96 | None | 0.83A | 5fsaB-5dqpA:undetectable | 5fsaB-5dqpA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fq6 | SUSC/RAGA FAMILYTONB-LINKED OUTERMEMBRANE PROTEIN (Bacteroidesthetaiotaomicron) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 3 | PRO B 135LEU B 64SER B 58 | None | 0.84A | 5fsaB-5fq6B:undetectable | 5fsaB-5fq6B:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gj8 | ACYL-COADEHYDROGENASE TYPE 2DOMAIN PROTEIN (Alicyclobacillusacidocaldarius) |
PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N)PF08028(Acyl-CoA_dh_2) | 3 | PRO A 42LEU A 24SER A 86 | None | 0.61A | 5fsaB-5gj8A:undetectable | 5fsaB-5gj8A:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gj8 | ACYL-COADEHYDROGENASE TYPE 2DOMAIN PROTEIN (Alicyclobacillusacidocaldarius) |
PF02771(Acyl-CoA_dh_N) | 3 | PRO D 42LEU D 24SER D 86 | None | 0.54A | 5fsaB-5gj8D:undetectable | 5fsaB-5gj8D:13.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h7j | ELONGATION FACTOR 2 (Pyrococcushorikoshii) |
no annotation | 3 | PRO A 130LEU A 692SER A 688 | None | 0.80A | 5fsaB-5h7jA:undetectable | 5fsaB-5h7jA:10.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hjr | NEUTRALALPHA-GLUCOSIDASE AB (Mus musculus) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 3 | PRO A 693LEU A 622SER A 664 | None | 0.65A | 5fsaB-5hjrA:undetectable | 5fsaB-5hjrA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iz5 | CYTOSOLICPHOSPHOLIPASE A2DELTA (Homo sapiens) |
no annotation | 3 | PRO B 45LEU B 134SER B 68 | None | 0.61A | 5fsaB-5iz5B:undetectable | 5fsaB-5iz5B:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jp3 | XANTHOMONAS OUTERPROTEIN D (Xanthomonaseuvesicatoria) |
PF02902(Peptidase_C48) | 3 | PRO A 503LEU A 412SER A 469 | None | 0.76A | 5fsaB-5jp3A:undetectable | 5fsaB-5jp3A:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ljo | OUTER MEMBRANEPROTEIN ASSEMBLYFACTOR BAMC (Escherichiacoli) |
PF06804(Lipoprotein_18) | 3 | PRO C 88LEU C 178SER C 105 | None | 0.57A | 5fsaB-5ljoC:undetectable | 5fsaB-5ljoC:16.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m59 | PRE-MRNA SPLICINGHELICASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF00270(DEAD)PF00271(Helicase_C)PF02889(Sec63) | 3 | PRO A 552LEU A 933SER A 727 | None | 0.63A | 5fsaB-5m59A:undetectable | 5fsaB-5m59A:13.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oat | SERINE/THREONINE-PROTEIN KINASE PINK1,MITOCHONDRIAL-LIKEPROTEIN (Triboliumcastaneum) |
no annotation | 3 | PRO A 473LEU A 338SER A 407 | None | 0.75A | 5fsaB-5oatA:undetectable | 5fsaB-5oatA:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tih | CYRPA ANTIBODY FABHEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 3 | PRO H 86LEU H 11SER H 17 | None | 0.72A | 5fsaB-5tihH:undetectable | 5fsaB-5tihH:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u22 | N2152 (Neocallimastixfrontalis) |
PF01229(Glyco_hydro_39) | 3 | PRO A 69LEU A 300SER A 65 | None | 0.84A | 5fsaB-5u22A:undetectable | 5fsaB-5u22A:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ubj | ALPHA-L-ARABINOFURANOSIDASE AXHA-2 (Aspergillusnidulans) |
PF03664(Glyco_hydro_62) | 3 | PRO A 55LEU A 300SER A 284 | None | 0.77A | 5fsaB-5ubjA:undetectable | 5fsaB-5ubjA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uhk | O-GLCNACASETIM-BARREL DOMAIN (Homo sapiens) |
PF07555(NAGidase) | 3 | PRO A 209LEU A 171SER A 168 | None | 0.85A | 5fsaB-5uhkA:undetectable | 5fsaB-5uhkA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uz5 | U1 SMALL NUCLEARRIBONUCLEOPROTEIN CU1 SMALL NUCLEARRIBONUCLEOPROTEINCOMPONENT PRP42 (Saccharomycescerevisiae) |
no annotation | 3 | PRO B 113LEU D 64SER D 266 | None | 0.69A | 5fsaB-5uz5B:undetectable | 5fsaB-5uz5B:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5via | PSEUDOPEROXIDASE (Leishmaniamajor) |
PF00141(peroxidase) | 3 | PRO A 59LEU A 332SER A 336 | None | 0.76A | 5fsaB-5viaA:undetectable | 5fsaB-5viaA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wtf | VP1 (Hepatovirus A) |
PF12944(HAV_VP) | 3 | PRO A 119LEU A 264SER A 271 | None | 0.62A | 5fsaB-5wtfA:undetectable | 5fsaB-5wtfA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xde | THERMOPHILICDIBENZOTHIOPHENEDESULFURIZATIONENZYME C (Paenibacillussp. A11-2) |
PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N)PF08028(Acyl-CoA_dh_2) | 3 | PRO A 42LEU A 24SER A 86 | None | 0.62A | 5fsaB-5xdeA:undetectable | 5fsaB-5xdeA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xpg | UNCHARACTERIZEDPROTEIN (Thermusthermophilus) |
no annotation | 3 | PRO A 330LEU A 455SER A 645 | None | 0.83A | 5fsaB-5xpgA:undetectable | 5fsaB-5xpgA:11.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y3r | DNA-DEPENDENTPROTEIN KINASECATALYTIC SUBUNIT (Homo sapiens) |
PF00454(PI3_PI4_kinase)PF02259(FAT)PF02260(FATC)PF08163(NUC194) | 3 | PRO C 897LEU C2563SER C2789 | None | 0.83A | 5fsaB-5y3rC:undetectable | 5fsaB-5y3rC:8.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yly | NITRATE REDUCTASE (Ulva prolifera) |
no annotation | 3 | PRO A 721LEU A 756SER A 760 | None | 0.80A | 5fsaB-5ylyA:undetectable | 5fsaB-5ylyA:11.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c08 | SODIUM-COUPLEDNEUTRAL AMINO ACIDTRANSPORTER 9 (Danio rerio) |
no annotation | 3 | PRO C 415LEU C 350SER C 492 | None | 0.71A | 5fsaB-6c08C:undetectable | 5fsaB-6c08C:9.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c66 | CRISPR-ASSOCIATEDPROTEIN, CSE1 FAMILY (Thermobifidafusca) |
no annotation | 3 | PRO A 307LEU A 260SER A 264 | None | 0.72A | 5fsaB-6c66A:undetectable | 5fsaB-6c66A:9.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6caa | ELECTROGENIC SODIUMBICARBONATECOTRANSPORTER 1 (Homo sapiens) |
no annotation | 3 | PRO A 795LEU A 482SER A 460 | None | 0.77A | 5fsaB-6caaA:undetectable | 5fsaB-6caaA:10.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cv0 | SPIKE GLYCOPROTEIN (Aviancoronavirus) |
no annotation | 3 | PRO A 770LEU A 681SER A 671 | None | 0.59A | 5fsaB-6cv0A:undetectable | 5fsaB-6cv0A:9.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cvq | APRATAXIN (Homo sapiens) |
no annotation | 3 | PRO A 206LEU A 213SER A 209 | None | 0.83A | 5fsaB-6cvqA:undetectable | 5fsaB-6cvqA:11.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cvq | APRATAXIN (Homo sapiens) |
no annotation | 3 | PRO A 254LEU A 203SER A 212 | AMP A 401 (-4.5A)AMP A 401 ( 4.7A)None | 0.84A | 5fsaB-6cvqA:undetectable | 5fsaB-6cvqA:11.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fkh | ATP SYNTHASE SUBUNITALPHA, CHLOROPLASTIC (Spinaciaoleracea) |
no annotation | 3 | PRO C 159LEU C 383SER C 369 | None | 0.84A | 5fsaB-6fkhC:undetectable | 5fsaB-6fkhC:10.99 |