SIMILAR PATTERNS OF AMINO ACIDS FOR 5FSA_B_X2NB590_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
3 PRO A 499
LEU A 643
SER A 635
None
0.80A 5fsaB-1bf2A:
0.0
5fsaB-1bf2A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsk ANTIBODY HEAVY CHAIN
FAB


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 PRO C  86
LEU C  11
SER C  17
None
0.55A 5fsaB-1fskC:
0.0
5fsaB-1fskC:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu1 GAMMA1-ADAPTIN

(Homo sapiens)
PF02883
(Alpha_adaptinC2)
3 PRO A 765
LEU A 798
SER A 768
None
0.78A 5fsaB-1iu1A:
undetectable
5fsaB-1iu1A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyb RIBONUCLEASE

(Nicotiana
glutinosa)
PF00445
(Ribonuclease_T2)
3 PRO A  14
LEU A 123
SER A  34
None
0.62A 5fsaB-1iybA:
0.0
5fsaB-1iybA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyb RIBONUCLEASE

(Nicotiana
glutinosa)
PF00445
(Ribonuclease_T2)
3 PRO A  14
LEU A 127
SER A  34
None
0.77A 5fsaB-1iybA:
0.0
5fsaB-1iybA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeq KU70

(Homo sapiens)
PF02037
(SAP)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N)
3 PRO A 370
LEU A 413
SER A 383
None
0.72A 5fsaB-1jeqA:
0.0
5fsaB-1jeqA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy5 CALSEPRRP

(Calystegia
sepium)
PF00445
(Ribonuclease_T2)
3 PRO A 199
LEU A 204
SER A 172
None
0.72A 5fsaB-1jy5A:
0.0
5fsaB-1jy5A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzk HEROIN ESTERASE

(Rhodococcus sp.)
PF07859
(Abhydrolase_3)
3 PRO A 180
LEU A  83
SER A 152
None
0.84A 5fsaB-1lzkA:
0.0
5fsaB-1lzkA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mh6 BLEOMYCIN RESISTANCE
PROTEIN


(Klebsiella
pneumoniae)
no annotation 3 PRO A 309
LEU A 245
SER A 216
None
0.73A 5fsaB-1mh6A:
undetectable
5fsaB-1mh6A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n9b BETA-LACTAMASE SHV-2

(Klebsiella
pneumoniae)
PF13354
(Beta-lactamase2)
3 PRO A 107
LEU A 122
SER A 130
None
None
EPE  A 400 (-2.5A)
0.78A 5fsaB-1n9bA:
0.0
5fsaB-1n9bA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum)
PF01425
(Amidase)
3 PRO A 115
LEU A 119
SER A 355
None
0.84A 5fsaB-1ocmA:
undetectable
5fsaB-1ocmA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT


(Propionibacterium
freudenreichii)
PF01039
(Carboxyl_trans)
3 PRO A 372
LEU A 317
SER A 340
None
0.58A 5fsaB-1on9A:
undetectable
5fsaB-1on9A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q47 SEMAPHORIN 3A

(Mus musculus)
PF01403
(Sema)
3 PRO A 415
LEU A 308
SER A 294
None
0.67A 5fsaB-1q47A:
undetectable
5fsaB-1q47A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE


(Rhodotorula
toruloides)
PF00221
(Lyase_aromatic)
3 PRO A 369
LEU A 335
SER A 310
None
0.82A 5fsaB-1t6pA:
1.5
5fsaB-1t6pA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqv THIAMINE
MONOPHOSPHATE KINASE


(Aquifex
aeolicus)
PF00586
(AIRS)
3 PRO A  57
LEU A  86
SER A  95
None
0.75A 5fsaB-1vqvA:
undetectable
5fsaB-1vqvA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI


(Escherichia
coli)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
3 PRO A 678
LEU A 340
SER A 268
None
0.73A 5fsaB-1we5A:
undetectable
5fsaB-1we5A:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis)
PF00067
(p450)
3 PRO A 178
LEU A  29
SER A 431
None
0.77A 5fsaB-1x8vA:
34.6
5fsaB-1x8vA:
30.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aey FRUCTAN
1-EXOHYDROLASE IIA


(Cichorium
intybus)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
3 PRO A 253
LEU A 266
SER A 258
None
0.57A 5fsaB-2aeyA:
undetectable
5fsaB-2aeyA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5y YKUV PROTEIN

(Bacillus
subtilis)
PF00578
(AhpC-TSA)
3 PRO A  70
LEU A  17
SER A  98
None
0.80A 5fsaB-2b5yA:
undetectable
5fsaB-2b5yA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhz RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR (GEF)-LIKE 1


(Homo sapiens)
no annotation 3 PRO A  17
LEU A  58
SER A  94
None
0.82A 5fsaB-2dhzA:
undetectable
5fsaB-2dhzA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djk PROTEIN
DISULFIDE-ISOMERASE


(Humicola
insolens)
PF13848
(Thioredoxin_6)
3 PRO A 120
LEU A  72
SER A 124
None
0.85A 5fsaB-2djkA:
undetectable
5fsaB-2djkA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9x DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2


(Homo sapiens)
PF05916
(Sld5)
3 PRO B  19
LEU B  33
SER B  22
None
0.79A 5fsaB-2e9xB:
undetectable
5fsaB-2e9xB:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)


(Arabidopsis
thaliana)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc)
3 PRO A 287
LEU A 189
SER A 183
None
0.82A 5fsaB-2fgeA:
undetectable
5fsaB-2fgeA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk0 D-PSICOSE
3-EPIMERASE


(Agrobacterium
tumefaciens)
PF01261
(AP_endonuc_2)
3 PRO A  68
LEU A 147
SER A 110
PRO  A  68 ( 1.1A)
LEU  A 147 ( 0.6A)
SER  A 110 ( 0.0A)
0.65A 5fsaB-2hk0A:
undetectable
5fsaB-2hk0A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3u YBBR FAMILY PROTEIN

(Desulfitobacterium
hafniense)
no annotation 3 PRO A  78
LEU A  24
SER A  28
None
0.76A 5fsaB-2l3uA:
undetectable
5fsaB-2l3uA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens)
PF01979
(Amidohydro_1)
3 PRO A 374
LEU A 409
SER A 439
None
0.76A 5fsaB-2oodA:
undetectable
5fsaB-2oodA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq3 MANNITOL-SPECIFIC
CRYPTIC
PHOSPHOTRANSFERASE
ENZYME IIA COMPONENT


(Escherichia
coli)
PF00359
(PTS_EIIA_2)
3 PRO A   8
LEU A 103
SER A  31
None
0.81A 5fsaB-2oq3A:
undetectable
5fsaB-2oq3A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnk 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE


(Homo sapiens)
PF06052
(3-HAO)
3 PRO A  86
LEU A 172
SER A 176
None
0.76A 5fsaB-2qnkA:
undetectable
5fsaB-2qnkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vak SIGMA A

(Avian
orthoreovirus)
PF03084
(Sigma_1_2)
3 PRO A  86
LEU A  80
SER A  20
None
0.68A 5fsaB-2vakA:
undetectable
5fsaB-2vakA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL


(Homo sapiens)
PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
3 PRO A 339
LEU A 305
SER A 342
None
0.84A 5fsaB-2xijA:
undetectable
5fsaB-2xijA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv5 YJEQ PROTEIN

(Aquifex
aeolicus)
PF03193
(RsgA_GTPase)
3 PRO A  92
LEU A  99
SER A 174
None
None
GDP  A1001 ( 4.1A)
0.85A 5fsaB-2yv5A:
undetectable
5fsaB-2yv5A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP


(Escherichia
coli)
PF02395
(Peptidase_S6)
3 PRO A 661
LEU A 752
SER A 689
None
0.74A 5fsaB-3ak5A:
undetectable
5fsaB-3ak5A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay5 CYCLIN-D1-BINDING
PROTEIN 1


(Homo sapiens)
PF13324
(GCIP)
3 PRO A  17
LEU A  77
SER A  81
None
0.69A 5fsaB-3ay5A:
undetectable
5fsaB-3ay5A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btp SINGLE-STRAND
DNA-BINDING PROTEIN


(Agrobacterium
fabrum)
PF07229
(VirE2)
3 PRO A 161
LEU A 264
SER A 258
None
0.78A 5fsaB-3btpA:
undetectable
5fsaB-3btpA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE


(Homo sapiens)
PF00305
(Lipoxygenase)
3 PRO A 558
LEU A 296
SER A 345
None
0.60A 5fsaB-3d3lA:
1.9
5fsaB-3d3lA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eay SENTRIN-SPECIFIC
PROTEASE 7


(Homo sapiens)
PF02902
(Peptidase_C48)
3 PRO A 788
LEU A 722
SER A 739
None
0.82A 5fsaB-3eayA:
undetectable
5fsaB-3eayA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fle SE_1780 PROTEIN

(Staphylococcus
epidermidis)
PF06028
(DUF915)
3 PRO A 164
LEU A  94
SER A 127
None
0.82A 5fsaB-3fleA:
undetectable
5fsaB-3fleA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fm0 PROTEIN CIAO1

(Homo sapiens)
PF00400
(WD40)
3 PRO A 160
LEU A 263
SER A 205
None
0.78A 5fsaB-3fm0A:
undetectable
5fsaB-3fm0A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE


(Vibrio cholerae)
PF00342
(PGI)
3 PRO A 407
LEU A 170
SER A 410
None
0.80A 5fsaB-3hjbA:
undetectable
5fsaB-3hjbA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3


(Thermus
thermophilus)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4)
3 PRO 3 551
LEU 3 345
SER 3 557
None
0.74A 5fsaB-3i9v3:
undetectable
5fsaB-3i9v3:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON


(Thermococcus
onnurineus)
PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32)
3 PRO A 581
LEU A 446
SER A 550
None
0.68A 5fsaB-3k1jA:
undetectable
5fsaB-3k1jA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwb PREPHENATE
DEHYDRATASE


(Paenarthrobacter
aurescens)
PF00800
(PDT)
PF01842
(ACT)
3 PRO A 191
LEU A 183
SER A 276
None
0.82A 5fsaB-3mwbA:
undetectable
5fsaB-3mwbA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT


(Allochromatium
vinosum)
PF00374
(NiFeSe_Hases)
3 PRO B1225
LEU B1228
SER B1232
None
0.81A 5fsaB-3myrB:
1.0
5fsaB-3myrB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ol2 SEMAPHORIN-4D

(Homo sapiens)
PF00047
(ig)
PF01403
(Sema)
PF01437
(PSI)
3 PRO A 406
LEU A 293
SER A 282
None
0.76A 5fsaB-3ol2A:
undetectable
5fsaB-3ol2A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN


(Homo sapiens)
PF04389
(Peptidase_M28)
3 PRO X 320
LEU X 339
SER X 323
None
0.61A 5fsaB-3pb9X:
undetectable
5fsaB-3pb9X:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE
REGULATORY PROTEIN


(Xenopus laevis)
no annotation 3 PRO B 453
LEU B 406
SER B 430
None
0.81A 5fsaB-3w0lB:
0.4
5fsaB-3w0lB:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whe HEMAGGLUTININ

(Influenza A
virus)
PF00509
(Hemagglutinin)
3 PRO A 215
LEU A 194
SER A 199
None
0.74A 5fsaB-3wheA:
undetectable
5fsaB-3wheA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 PRO H  82
LEU H  11
SER H  17
None
0.75A 5fsaB-4ag4H:
undetectable
5fsaB-4ag4H:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5q GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN D


(Phanerochaete
chrysosporium)
PF03443
(Glyco_hydro_61)
3 PRO A  10
LEU A 141
SER A  61
None
0.81A 5fsaB-4b5qA:
undetectable
5fsaB-4b5qA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blf SINGLE-STRAND
DNA-BINDING PROTEIN


(Agrobacterium
tumefaciens)
PF07229
(VirE2)
3 PRO A 161
LEU A 264
SER A 258
None
0.79A 5fsaB-4blfA:
undetectable
5fsaB-4blfA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin)
3 PRO B 363
LEU B  92
SER B 413
None
0.76A 5fsaB-4cakB:
undetectable
5fsaB-4cakB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe)
PF11715
(Nup160)
3 PRO B  96
LEU B 673
SER B  92
None
0.79A 5fsaB-4fhnB:
undetectable
5fsaB-4fhnB:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbr BETA-2 ADRENERGIC
RECEPTOR


(Homo sapiens)
PF00001
(7tm_1)
3 PRO A 211
LEU A 259
SER A 207
None
None
CAU  A 500 (-4.1A)
0.82A 5fsaB-4gbrA:
0.0
5fsaB-4gbrA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq1 NUP37

(Schizosaccharomyces
pombe)
PF00400
(WD40)
3 PRO A 195
LEU A 283
SER A 264
None
0.83A 5fsaB-4gq1A:
undetectable
5fsaB-4gq1A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz8 SEMAPHORIN-3A

(Mus musculus)
PF01403
(Sema)
3 PRO A 415
LEU A 308
SER A 294
None
0.70A 5fsaB-4gz8A:
undetectable
5fsaB-4gz8A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE


(Burkholderia
lata)
PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C)
3 PRO A 169
LEU A 162
SER A 137
None
0.68A 5fsaB-4hmwA:
undetectable
5fsaB-4hmwA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kys THIAMINE
PYRIDINYLASE I


(Clostridium
botulinum)
PF01547
(SBP_bac_1)
3 PRO A 246
LEU A 186
SER A 251
None
0.54A 5fsaB-4kysA:
undetectable
5fsaB-4kysA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l15 FIDGETIN-LIKE
PROTEIN 1


(Caenorhabditis
elegans)
PF00004
(AAA)
PF09336
(Vps4_C)
3 PRO A 357
LEU A 321
SER A 519
None
0.70A 5fsaB-4l15A:
undetectable
5fsaB-4l15A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE


(Aspergillus
fischeri)
PF11991
(Trp_DMAT)
3 PRO A 243
LEU A 281
SER A 346
None
0.72A 5fsaB-4ld7A:
undetectable
5fsaB-4ld7A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1


(Homo sapiens)
PF00400
(WD40)
3 PRO A 179
LEU A 231
SER A 235
None
0.77A 5fsaB-4lg9A:
undetectable
5fsaB-4lg9A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A


(Ustilago maydis)
PF03664
(Glyco_hydro_62)
3 PRO A  41
LEU A 283
SER A 267
None
0.81A 5fsaB-4n2rA:
undetectable
5fsaB-4n2rA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN


(Bacteroides
thetaiotaomicron)
PF16819
(DUF5074)
PF16820
(PKD_3)
3 PRO A 348
LEU A 398
SER A 442
None
0.71A 5fsaB-4r5oA:
undetectable
5fsaB-4r5oA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus)
PF14498
(Glyco_hyd_65N_2)
3 PRO A 188
LEU A  59
SER A 360
None
0.72A 5fsaB-4ufcA:
undetectable
5fsaB-4ufcA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6z ALCOHOL
DEHYDROGENASE 1


(Saccharomyces
cerevisiae)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 PRO A 271
LEU A 182
SER A 248
None
8ID  A 403 (-3.3A)
8ID  A 403 (-3.5A)
0.78A 5fsaB-4w6zA:
undetectable
5fsaB-4w6zA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A


(Pseudomonas
aeruginosa)
PF01425
(Amidase)
3 PRO A 180
LEU A 120
SER A 176
None
0.83A 5fsaB-4wj3A:
1.1
5fsaB-4wj3A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xk1 PHOSPHOSERINE
AMINOTRANSFERASE


(Pseudomonas
aeruginosa)
PF00266
(Aminotran_5)
3 PRO A 132
LEU A 139
SER A 122
None
0.74A 5fsaB-4xk1A:
undetectable
5fsaB-4xk1A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL


(Mus musculus)
PF01370
(Epimerase)
3 PRO A 223
LEU A 355
SER A 294
None
0.82A 5fsaB-4yraA:
undetectable
5fsaB-4yraA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyl RPHYB PROTEIN

(Rhodopseudomonas
palustris)
PF00072
(Response_reg)
3 PRO A   8
LEU A 136
SER A  33
None
0.78A 5fsaB-4zylA:
undetectable
5fsaB-4zylA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a20 MAJOR TAIL PROTEIN
GP17.1


(Bacillus phage
SPP1)
PF06199
(Phage_tail_2)
3 PRO H 147
LEU H  43
SER H  58
None
0.44A 5fsaB-5a20H:
undetectable
5fsaB-5a20H:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3f DYNAMIN 3

(Homo sapiens)
PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED)
3 PRO A  68
LEU A  29
SER A 117
None
0.77A 5fsaB-5a3fA:
0.1
5fsaB-5a3fA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqp EDTA MONOOXYGENASE

(EDTA-degrading
bacterium BNC1)
PF00296
(Bac_luciferase)
3 PRO A  59
LEU A  55
SER A  96
None
0.83A 5fsaB-5dqpA:
undetectable
5fsaB-5dqpA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN


(Bacteroides
thetaiotaomicron)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
3 PRO B 135
LEU B  64
SER B  58
None
0.84A 5fsaB-5fq6B:
undetectable
5fsaB-5fq6B:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN


(Alicyclobacillus
acidocaldarius)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2)
3 PRO A  42
LEU A  24
SER A  86
None
0.61A 5fsaB-5gj8A:
undetectable
5fsaB-5gj8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN


(Alicyclobacillus
acidocaldarius)
PF02771
(Acyl-CoA_dh_N)
3 PRO D  42
LEU D  24
SER D  86
None
0.54A 5fsaB-5gj8D:
undetectable
5fsaB-5gj8D:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii)
no annotation 3 PRO A 130
LEU A 692
SER A 688
None
0.80A 5fsaB-5h7jA:
undetectable
5fsaB-5h7jA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB


(Mus musculus)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
3 PRO A 693
LEU A 622
SER A 664
None
0.65A 5fsaB-5hjrA:
undetectable
5fsaB-5hjrA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA


(Homo sapiens)
no annotation 3 PRO B  45
LEU B 134
SER B  68
None
0.61A 5fsaB-5iz5B:
undetectable
5fsaB-5iz5B:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp3 XANTHOMONAS OUTER
PROTEIN D


(Xanthomonas
euvesicatoria)
PF02902
(Peptidase_C48)
3 PRO A 503
LEU A 412
SER A 469
None
0.76A 5fsaB-5jp3A:
undetectable
5fsaB-5jp3A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMC


(Escherichia
coli)
PF06804
(Lipoprotein_18)
3 PRO C  88
LEU C 178
SER C 105
None
0.57A 5fsaB-5ljoC:
undetectable
5fsaB-5ljoC:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
3 PRO A 552
LEU A 933
SER A 727
None
0.63A 5fsaB-5m59A:
undetectable
5fsaB-5m59A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN


(Tribolium
castaneum)
no annotation 3 PRO A 473
LEU A 338
SER A 407
None
0.75A 5fsaB-5oatA:
undetectable
5fsaB-5oatA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tih CYRPA ANTIBODY FAB
HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 PRO H  86
LEU H  11
SER H  17
None
0.72A 5fsaB-5tihH:
undetectable
5fsaB-5tihH:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u22 N2152

(Neocallimastix
frontalis)
PF01229
(Glyco_hydro_39)
3 PRO A  69
LEU A 300
SER A  65
None
0.84A 5fsaB-5u22A:
undetectable
5fsaB-5u22A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubj ALPHA-L-ARABINOFURAN
OSIDASE AXHA-2


(Aspergillus
nidulans)
PF03664
(Glyco_hydro_62)
3 PRO A  55
LEU A 300
SER A 284
None
0.77A 5fsaB-5ubjA:
undetectable
5fsaB-5ubjA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhk O-GLCNACASE
TIM-BARREL DOMAIN


(Homo sapiens)
PF07555
(NAGidase)
3 PRO A 209
LEU A 171
SER A 168
None
0.85A 5fsaB-5uhkA:
undetectable
5fsaB-5uhkA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN C
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42


(Saccharomyces
cerevisiae)
no annotation 3 PRO B 113
LEU D  64
SER D 266
None
0.69A 5fsaB-5uz5B:
undetectable
5fsaB-5uz5B:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5via PSEUDOPEROXIDASE

(Leishmania
major)
PF00141
(peroxidase)
3 PRO A  59
LEU A 332
SER A 336
None
0.76A 5fsaB-5viaA:
undetectable
5fsaB-5viaA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtf VP1

(Hepatovirus A)
PF12944
(HAV_VP)
3 PRO A 119
LEU A 264
SER A 271
None
0.62A 5fsaB-5wtfA:
undetectable
5fsaB-5wtfA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C


(Paenibacillus
sp. A11-2)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2)
3 PRO A  42
LEU A  24
SER A  86
None
0.62A 5fsaB-5xdeA:
undetectable
5fsaB-5xdeA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN


(Thermus
thermophilus)
no annotation 3 PRO A 330
LEU A 455
SER A 645
None
0.83A 5fsaB-5xpgA:
undetectable
5fsaB-5xpgA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT


(Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194)
3 PRO C 897
LEU C2563
SER C2789
None
0.83A 5fsaB-5y3rC:
undetectable
5fsaB-5y3rC:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yly NITRATE REDUCTASE

(Ulva prolifera)
no annotation 3 PRO A 721
LEU A 756
SER A 760
None
0.80A 5fsaB-5ylyA:
undetectable
5fsaB-5ylyA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 SODIUM-COUPLED
NEUTRAL AMINO ACID
TRANSPORTER 9


(Danio rerio)
no annotation 3 PRO C 415
LEU C 350
SER C 492
None
0.71A 5fsaB-6c08C:
undetectable
5fsaB-6c08C:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY


(Thermobifida
fusca)
no annotation 3 PRO A 307
LEU A 260
SER A 264
None
0.72A 5fsaB-6c66A:
undetectable
5fsaB-6c66A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1


(Homo sapiens)
no annotation 3 PRO A 795
LEU A 482
SER A 460
None
0.77A 5fsaB-6caaA:
undetectable
5fsaB-6caaA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv0 SPIKE GLYCOPROTEIN

(Avian
coronavirus)
no annotation 3 PRO A 770
LEU A 681
SER A 671
None
0.59A 5fsaB-6cv0A:
undetectable
5fsaB-6cv0A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cvq APRATAXIN

(Homo sapiens)
no annotation 3 PRO A 206
LEU A 213
SER A 209
None
0.83A 5fsaB-6cvqA:
undetectable
5fsaB-6cvqA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cvq APRATAXIN

(Homo sapiens)
no annotation 3 PRO A 254
LEU A 203
SER A 212
AMP  A 401 (-4.5A)
AMP  A 401 ( 4.7A)
None
0.84A 5fsaB-6cvqA:
undetectable
5fsaB-6cvqA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC


(Spinacia
oleracea)
no annotation 3 PRO C 159
LEU C 383
SER C 369
None
0.84A 5fsaB-6fkhC:
undetectable
5fsaB-6fkhC:
10.99