SIMILAR PATTERNS OF AMINO ACIDS FOR 5FSA_B_X2NB590_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a04 NITRATE/NITRITE
RESPONSE REGULATOR
PROTEIN NARL


(Escherichia
coli)
PF00072
(Response_reg)
PF00196
(GerE)
5 GLY A  21
GLN A  24
LEU A  55
GLY A 126
PHE A  86
None
1.23A 5fsaB-1a04A:
undetectable
5fsaB-1a04A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE


(Bacillus
subtilis)
PF00156
(Pribosyltran)
PF13522
(GATase_6)
5 GLY A  27
GLN A  24
LEU A 180
ILE A 216
HIS A  70
None
1.18A 5fsaB-1ao0A:
undetectable
5fsaB-1ao0A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hc7 PROLYL-TRNA
SYNTHETASE


(Thermus
thermophilus)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1)
5 TYR A 182
GLY A 227
GLN A 225
PHE A 236
GLY A 117
None
1.08A 5fsaB-1hc7A:
0.0
5fsaB-1hc7A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg8 ENDOPOLYGALACTURONAS
E


(Fusarium
verticillioides)
PF00295
(Glyco_hydro_28)
6 TYR A 112
GLY A 109
GLN A 110
LEU A  58
PHE A  71
ILE A  95
None
1.41A 5fsaB-1hg8A:
0.0
5fsaB-1hg8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE


(Thermococcus
litoralis)
PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926)
5 GLY A  52
PHE A 238
PHE A  34
ILE A 241
HIS A  49
None
1.19A 5fsaB-1k1xA:
0.0
5fsaB-1k1xA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6u TRYPTOPHANYL-TRNA
SYNTHETASE


(Homo sapiens)
PF00579
(tRNA-synt_1b)
5 GLY A 265
LEU A 103
PHE A 138
ILE A 136
PHE A  84
None
1.18A 5fsaB-1r6uA:
0.0
5fsaB-1r6uA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw9 CHONDROITIN AC LYASE

(Paenarthrobacter
aurescens)
PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N)
5 GLY A 481
TYR A 626
ILE A 450
GLY A 422
HIS A 376
None
1.16A 5fsaB-1rw9A:
undetectable
5fsaB-1rw9A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s58 B19 PARVOVIRUS
CAPSID


(Primate
erythroparvovirus
1)
PF00740
(Parvo_coat)
5 TYR A 161
GLN A 451
PHE A  99
PHE A 492
ILE A 108
None
1.26A 5fsaB-1s58A:
undetectable
5fsaB-1s58A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT
QUINOLINE
2-OXIDOREDUCTASE
SMALL SUBUNIT


(Pseudomonas
putida)
PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
5 GLY B 509
GLN B 508
LEU B  27
ILE A 121
HIS A 103
MCN  B4921 ( 4.3A)
MCN  B4921 (-3.8A)
None
None
None
1.28A 5fsaB-1t3qB:
2.0
5fsaB-1t3qB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER


(Escherichia
coli)
PF00909
(Ammonium_transp)
5 TYR A 374
GLY A 373
PHE A 215
GLY A 163
THR A 165
None
None
NH3  A 402 (-3.4A)
None
None
1.16A 5fsaB-1u7gA:
undetectable
5fsaB-1u7gA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1


(Methylobacterium
extorquens)
PF01011
(PQQ)
PF13360
(PQQ_2)
5 GLY A 428
GLN A 429
LEU A 129
ILE A 517
GLY A 539
None
None
None
None
PQQ  A1596 (-3.5A)
1.05A 5fsaB-1w6sA:
undetectable
5fsaB-1w6sA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN 1


(Pyrococcus
furiosus)
PF00290
(Trp_syntA)
PF00291
(PALP)
5 GLY A 111
PHE B 274
PHE A  41
GLY B 287
PHE A 125
None
1.22A 5fsaB-1wdwA:
undetectable
5fsaB-1wdwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9e HMG-COA SYNTHASE

(Enterococcus
faecalis)
PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C)
5 TYR A 227
LEU A 281
TYR A 112
ILE A  75
PHE A 314
None
1.18A 5fsaB-1x9eA:
undetectable
5fsaB-1x9eA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahn THAUMATIN-LIKE
PROTEIN


(Prunus avium)
PF00314
(Thaumatin)
5 GLY A 213
LEU A  41
PHE A  31
PHE A   5
GLY A  16
None
1.28A 5fsaB-2ahnA:
undetectable
5fsaB-2ahnA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT


(Pseudomonas
fragi)
PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
5 GLY A 392
LEU A 412
PHE A 447
GLY A 449
THR A 478
None
1.21A 5fsaB-2d3tA:
undetectable
5fsaB-2d3tA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN


(Pyrococcus
horikoshii)
PF00005
(ABC_tran)
PF08402
(TOBE_2)
5 GLY A 291
LEU A 331
PHE A 342
THR A 303
PHE A 266
None
1.23A 5fsaB-2d62A:
undetectable
5fsaB-2d62A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum)
PF12891
(Glyco_hydro_44)
5 TYR A 362
LEU A 355
ILE A 227
GLY A 229
PHE A 381
None
1.12A 5fsaB-2e0pA:
undetectable
5fsaB-2e0pA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
5 GLY A 374
LEU A 203
ILE A 189
GLY A 190
THR A 172
None
None
None
None
FAD  A1002 (-4.1A)
1.18A 5fsaB-2e5vA:
undetectable
5fsaB-2e5vA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9y CARBAMATE KINASE

(Aeropyrum
pernix)
PF00696
(AA_kinase)
5 GLY A 196
GLN A  86
LEU A 232
GLY A 296
THR A 236
None
1.13A 5fsaB-2e9yA:
undetectable
5fsaB-2e9yA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis)
PF01274
(Malate_synthase)
5 TYR A 555
GLN A 557
ILE A 639
THR A 517
HIS A 551
None
1.23A 5fsaB-2gq3A:
undetectable
5fsaB-2gq3A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI


(Haemophilus
haemolyticus)
PF00145
(DNA_methylase)
5 GLY A 158
LEU A 251
TYR A 299
ILE A 207
GLY A 264
None
1.22A 5fsaB-2i9kA:
undetectable
5fsaB-2i9kA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ich PUTATIVE ATTH

(Nitrosomonas
europaea)
PF07143
(CrtC)
PF17186
(Lipocalin_9)
5 GLY A 171
PHE A 333
GLY A 343
THR A  53
PHE A 244
None
None
None
None
NHE  A   1 (-3.6A)
1.28A 5fsaB-2ichA:
undetectable
5fsaB-2ichA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odl ADHESIN

(Haemophilus
influenzae)
PF05860
(Haemagg_act)
5 GLY A 166
GLN A 145
LEU A 233
GLY A 216
THR A 171
None
1.19A 5fsaB-2odlA:
undetectable
5fsaB-2odlA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p24 H-2 CLASS II
HISTOCOMPATIBILITY
ANTIGEN, A-U ALPHA
CHAIN
H-2 CLASS II
HISTOCOMPATIBILITY
ANTIGEN, A-U BETA
CHAIN


(Mus musculus)
PF00969
(MHC_II_beta)
PF00993
(MHC_II_alpha)
PF07654
(C1-set)
5 GLY B   1
TYR A 133
PHE A 138
ILE A 106
GLY B 251
None
1.29A 5fsaB-2p24B:
undetectable
5fsaB-2p24B:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1


(Saccharomyces
cerevisiae)
PF00393
(6PGD)
PF03446
(NAD_binding_2)
5 GLY A 129
PHE A 394
TYR A 379
PHE A 371
HIS A 185
FLC  A 502 ( 4.5A)
None
None
None
FLC  A 502 (-4.5A)
1.11A 5fsaB-2p4qA:
undetectable
5fsaB-2p4qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qiw PEP PHOSPHONOMUTASE

(Corynebacterium
glutamicum)
PF13714
(PEP_mutase)
5 GLY A 228
LEU A  23
PHE A  11
ILE A 101
GLY A 108
GOL  A 259 (-3.6A)
None
None
None
None
1.04A 5fsaB-2qiwA:
undetectable
5fsaB-2qiwA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjp CYTOCHROME B

(Rhodobacter
sphaeroides)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
5 GLY A 152
GLN A 153
LEU A 181
ILE A 169
GLY A 167
None
1.25A 5fsaB-2qjpA:
0.0
5fsaB-2qjpA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmi PBP RELATED
BETA-LACTAMASE


(Pyrococcus
abyssi)
PF00144
(Beta-lactamase)
PF13969
(Pab87_oct)
5 TYR A 284
ILE A 215
GLY A 307
THR A 310
HIS A 302
None
1.29A 5fsaB-2qmiA:
undetectable
5fsaB-2qmiA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rau PUTATIVE ESTERASE

(Sulfolobus
solfataricus)
PF12146
(Hydrolase_4)
5 GLY A 154
LEU A 329
ILE A 217
GLY A 211
PHE A 304
None
None
CA  A 354 ( 3.9A)
None
None
1.20A 5fsaB-2rauA:
undetectable
5fsaB-2rauA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6o THIOREDOXIN
GLUTATHIONE
REDUCTASE


(Schistosoma
mansoni)
PF00462
(Glutaredoxin)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 TYR A 212
GLY A 151
PHE A 474
ILE A 547
GLY A 545
None
1.28A 5fsaB-2v6oA:
undetectable
5fsaB-2v6oA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8j PECTATE LYASE

(Yersinia
enterocolitica)
PF06917
(Pectate_lyase_2)
5 LEU A 131
TYR A 135
PHE A 156
THR A 169
PHE A 513
None
1.28A 5fsaB-2v8jA:
undetectable
5fsaB-2v8jA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vtc CEL61B

(Trichoderma
reesei)
PF03443
(Glyco_hydro_61)
5 PHE A 211
TYR A 214
ILE A 123
GLY A  92
HIS A   1
None
None
None
None
NI  A1231 (-3.2A)
1.16A 5fsaB-2vtcA:
undetectable
5fsaB-2vtcA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING


(Geobacillus
stearothermophilus)
PF00393
(6PGD)
PF03446
(NAD_binding_2)
5 GLY A 129
PHE A 394
TYR A 379
PHE A 371
HIS A 185
6PG  A1470 (-3.7A)
None
None
None
6PG  A1470 (-4.5A)
1.10A 5fsaB-2w8zA:
undetectable
5fsaB-2w8zA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE


(Pseudomonas
aeruginosa)
PF01370
(Epimerase)
5 TYR A  54
PHE A 333
GLY A 194
THR A 192
HIS A  26
None
1.10A 5fsaB-2x4gA:
undetectable
5fsaB-2x4gA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1


(Homo sapiens)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
5 GLY A 676
GLN A 675
LEU A 686
GLY A 920
PHE A 699
None
0.90A 5fsaB-2yd0A:
undetectable
5fsaB-2yd0A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING


(Klebsiella
pneumoniae)
PF00393
(6PGD)
PF03446
(NAD_binding_2)
5 GLY A 129
PHE A 393
TYR A 378
PHE A 370
HIS A 186
None
1.16A 5fsaB-2zygA:
undetectable
5fsaB-2zygA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
5 LEU A 463
PHE A 143
ILE A 173
GLY A 225
HIS A 396
None
None
None
None
C2O  A 702 ( 3.3A)
1.23A 5fsaB-3aw5A:
undetectable
5fsaB-3aw5A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb7 INTERPAIN A

(Prevotella
intermedia)
PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69)
5 GLY A 292
LEU A 163
TYR A 199
PHE A 259
GLY A 258
None
1.19A 5fsaB-3bb7A:
undetectable
5fsaB-3bb7A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be8 NEUROLIGIN-4,
X-LINKED


(Homo sapiens)
PF00135
(COesterase)
5 LEU A 132
PHE A 128
ILE A 172
GLY A 174
HIS A 113
None
None
None
PO4  A 623 ( 3.6A)
None
1.25A 5fsaB-3be8A:
undetectable
5fsaB-3be8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans)
PF00149
(Metallophos)
5 GLN A 125
LEU A 177
ILE A 220
GLY A 247
THR A  33
None
1.14A 5fsaB-3c9fA:
undetectable
5fsaB-3c9fA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9t L-TYROSINE
DECARBOXYLASE MFNA


(Methanocaldococcus
jannaschii)
PF00282
(Pyridoxal_deC)
5 GLY A 288
LEU A 298
PHE A 216
ILE A 214
GLY A 211
None
1.23A 5fsaB-3f9tA:
undetectable
5fsaB-3f9tA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcj NITROALKANE OXIDASE

(Fusarium
oxysporum)
PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N)
5 GLY A 267
GLN A 266
ILE A 285
GLY A 281
THR A 358
None
0.95A 5fsaB-3fcjA:
undetectable
5fsaB-3fcjA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19


(Rhodobacter
sphaeroides)
PF01244
(Peptidase_M19)
6 GLY A 313
LEU A  38
PHE A  53
PHE A  48
ILE A 133
GLY A  51
None
1.41A 5fsaB-3fdgA:
undetectable
5fsaB-3fdgA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2


(Mus musculus)
PF04916
(Phospholip_B)
5 GLY A 377
GLN A 408
LEU A 168
GLY A 218
PHE A 163
None
1.15A 5fsaB-3fgwA:
undetectable
5fsaB-3fgwA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw6 CELLULASE

(uncultured
bacterium)
PF12891
(Glyco_hydro_44)
5 GLY A 272
GLN A 280
LEU A 310
GLY A 250
PHE A 325
None
1.06A 5fsaB-3fw6A:
undetectable
5fsaB-3fw6A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hy8 PYRIDOXINE-5'-PHOSPH
ATE OXIDASE


(Homo sapiens)
PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C)
5 GLY A 144
GLN A 214
LEU A 149
TYR A 157
PHE A 109
None
None
None
PO4  A 360 (-3.7A)
None
1.24A 5fsaB-3hy8A:
undetectable
5fsaB-3hy8A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE


(Cupriavidus
pinatubonensis)
PF00465
(Fe-ADH)
5 GLY A 249
LEU A 166
GLY A  96
THR A 100
HIS A  71
None
None
None
None
NAD  A 400 (-3.4A)
1.24A 5fsaB-3jzdA:
undetectable
5fsaB-3jzdA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mda DNA POLYMERASE
LAMBDA


(Homo sapiens)
PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm)
5 GLY A 508
LEU A 532
GLY A 524
THR A 522
PHE A 560
None
1.25A 5fsaB-3mdaA:
undetectable
5fsaB-3mdaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0h GLUTATHIONE
REDUCTASE


(Bartonella
henselae)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 TYR A  99
GLY A  40
PHE A 345
ILE A 414
GLY A 412
None
1.07A 5fsaB-3o0hA:
undetectable
5fsaB-3o0hA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B


(Pseudomonas
aeruginosa)
PF00115
(COX1)
5 GLY B 408
GLN B 411
PHE B 261
ILE B 254
GLY B 257
None
1.04A 5fsaB-3o0rB:
undetectable
5fsaB-3o0rB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS


(Aspergillus
oryzae)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 GLY A 402
LEU A  97
GLY A 211
THR A 203
PHE A 512
None
FAY  A 600 (-4.9A)
None
None
FAY  A 600 (-3.6A)
1.25A 5fsaB-3q9tA:
undetectable
5fsaB-3q9tA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1


(Homo sapiens)
PF11838
(ERAP1_C)
5 GLY A 676
GLN A 675
LEU A 686
GLY A 920
PHE A 699
None
0.94A 5fsaB-3rjoA:
undetectable
5fsaB-3rjoA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M


(Escherichia
coli)
no annotation 5 GLY M 413
GLN M 416
LEU M 272
ILE M  83
GLY M  85
None
1.19A 5fsaB-3rkoM:
undetectable
5fsaB-3rkoM:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tnl SHIKIMATE
DEHYDROGENASE


(Listeria
monocytogenes)
PF08501
(Shikimate_dh_N)
5 GLY A 269
GLN A 268
LEU A  15
PHE A  48
PHE A  36
None
SKM  A 293 (-3.3A)
None
None
None
1.22A 5fsaB-3tnlA:
undetectable
5fsaB-3tnlA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1h 3-ISOPROPYLMALATE
DEHYDROGENASE


(Bacillus sp.
(in: Bacteria))
PF00180
(Iso_dh)
5 GLY A 309
TYR A  40
GLY A  72
THR A 296
PHE A  36
None
0.95A 5fsaB-3u1hA:
undetectable
5fsaB-3u1hA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsy SORTILIN-RELATED
RECEPTOR


(Homo sapiens)
PF15901
(Sortilin_C)
PF15902
(Sortilin-Vps10)
5 GLY A 238
LEU A 231
PHE A 284
ILE A 293
THR A 263
None
1.11A 5fsaB-3wsyA:
undetectable
5fsaB-3wsyA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP


(Corynebacterium
glutamicum)
PF02028
(BCCT)
5 PHE A 380
TYR A 197
GLY A 249
THR A 522
PHE A 110
None
1.22A 5fsaB-4ainA:
undetectable
5fsaB-4ainA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bob ERPP PROTEIN

(Borreliella
burgdorferi)
PF02471
(OspE)
5 LEU A  52
PHE A  77
ILE A 121
GLY A 138
THR A 150
None
1.18A 5fsaB-4bobA:
undetectable
5fsaB-4bobA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans)
PF00232
(Glyco_hydro_1)
5 GLY A 261
ILE A 165
GLY A 175
THR A 181
PHE A 291
None
1.28A 5fsaB-4ha4A:
undetectable
5fsaB-4ha4A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4b PYLD

(Methanosarcina
barkeri)
no annotation 5 LEU A 101
PHE A  63
PHE A 108
THR A 125
PHE A  76
None
0TF  A 904 (-3.8A)
None
NAI  A 901 (-3.4A)
None
1.18A 5fsaB-4j4bA:
undetectable
5fsaB-4j4bA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8p FLAVODOXIN

(Bacteroides
uniformis)
PF12682
(Flavodoxin_4)
5 GLY A  36
PHE A 126
TYR A  99
PHE A 120
PHE A  53
GOL  A 206 ( 3.3A)
None
GOL  A 203 (-4.7A)
None
None
1.22A 5fsaB-4j8pA:
undetectable
5fsaB-4j8pA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcs ENOYL-COA
HYDRATASE/ISOMERASE


(Cupriavidus
metallidurans)
PF00378
(ECH_1)
5 GLY A  13
LEU A 115
PHE A  26
ILE A  83
GLY A  86
None
1.18A 5fsaB-4jcsA:
undetectable
5fsaB-4jcsA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE


(Agaricus
bisporus)
PF00264
(Tyrosinase)
5 GLY A 135
LEU A 205
ILE A 263
GLY A 265
THR A 268
None
1.27A 5fsaB-4ouaA:
0.4
5fsaB-4ouaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psw HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT
HISTONE
ACETYLTRANSFERASE
TYPE B SUBUNIT 2
HISTONE H4 TYPE VIII


(Ophiophagus
hannah;
Saccharomyces
cerevisiae)
PF00400
(WD40)
PF00583
(Acetyltransf_1)
PF10394
(Hat1_N)
PF12265
(CAF1C_H4-bd)
no annotation
5 TYR A 194
GLY C  11
LEU B 278
PHE B 303
GLY B 309
None
1.23A 5fsaB-4pswA:
undetectable
5fsaB-4pswA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN


(Zea mays)
PF00171
(Aldedh)
5 GLY A 270
GLN A 423
LEU A 343
PHE A 352
GLY A 370
None
1.25A 5fsaB-4pxnA:
undetectable
5fsaB-4pxnA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlv ADP-RIBOSYLATING
TOXIN CARDS


(Mycoplasma
pneumoniae)
PF02917
(Pertussis_S1)
5 LEU A 403
ILE A 280
GLY A 279
THR A 285
PHE A 315
None
1.26A 5fsaB-4tlvA:
undetectable
5fsaB-4tlvA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpn PUTATIVE P450-LIKE
PROTEIN


(Streptomyces
scabiei)
PF00067
(p450)
5 GLY A 226
LEU A 239
TYR A 199
GLY A 156
THR A 215
None
1.28A 5fsaB-4tpnA:
26.6
5fsaB-4tpnA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy6 HISTIDINE-SPECIFIC
METHYLTRANSFERASE
EGTD


(Mycolicibacterium
smegmatis)
PF10017
(Methyltransf_33)
5 GLY A  25
LEU A 167
PHE A 159
PHE A 142
GLY A  86
None
None
None
SAH  A 801 (-3.4A)
SAH  A 801 (-3.0A)
1.01A 5fsaB-4uy6A:
undetectable
5fsaB-4uy6A:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uym 14-ALPHA STEROL
DEMETHYLASE


(Aspergillus
fumigatus)
PF00067
(p450)
5 LEU A 125
PHE A 130
TYR A 136
PHE A 229
HIS A 374
None
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
None
None
1.20A 5fsaB-4uymA:
51.5
5fsaB-4uymA:
50.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uym 14-ALPHA STEROL
DEMETHYLASE


(Aspergillus
fumigatus)
PF00067
(p450)
6 TYR A  68
GLY A  69
LEU A 125
PHE A 130
TYR A 136
HIS A 374
None
None
None
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
None
1.01A 5fsaB-4uymA:
51.5
5fsaB-4uymA:
50.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs ECU04_1440 PROTEIN
SIMILARITY TO
HELICASE MOT1


(Encephalitozoon
cuniculi)
PF00352
(TBP)
no annotation
5 GLY C  93
GLN C  95
LEU D 104
PHE C 213
ILE C 293
None
1.10A 5fsaB-4wzsC:
undetectable
5fsaB-4wzsC:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Rhodobacter
sphaeroides)
PF03480
(DctP)
5 GLY A 192
PHE A 131
PHE A  93
ILE A 137
THR A  78
None
1.27A 5fsaB-4x8rA:
undetectable
5fsaB-4x8rA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG


(Bacillus
subtilis)
PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C)
5 LEU A 302
TYR A 115
PHE A 303
ILE A  78
PHE A 334
None
1.04A 5fsaB-4yxtA:
undetectable
5fsaB-4yxtA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT


(Azospira oryzae)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
5 TYR A 875
GLY A 876
GLN A 485
ILE A 395
PHE A 737
None
1.24A 5fsaB-5chcA:
undetectable
5fsaB-5chcA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfw SINGLE CHAIN FV
FRAGMENT


(Mus musculus)
PF07686
(V-set)
5 TYR H 602
GLN H 604
ILE H 308
THR H 124
PHE H 753
None
1.29A 5fsaB-5dfwH:
undetectable
5fsaB-5dfwH:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee0 OBG-LIKE ATPASE 1

(Oryza sativa)
PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C)
5 GLY A  19
LEU A  90
PHE A 123
THR A 258
HIS A 303
None
1.25A 5fsaB-5ee0A:
undetectable
5fsaB-5ee0A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey7 FRUCTOKINASE

(Vibrio cholerae)
PF00294
(PfkB)
5 GLY A 307
LEU A  80
PHE A  63
GLY A  65
PHE A  75
NA  A 401 (-4.3A)
None
None
None
None
1.25A 5fsaB-5ey7A:
undetectable
5fsaB-5ey7A:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE


(Saccharomyces
cerevisiae)
PF00067
(p450)
5 TYR A  72
GLY A  73
GLY A 315
THR A 318
HIS A 381
None
None
HEM  A 601 (-3.5A)
HEM  A 601 (-3.4A)
None
0.86A 5fsaB-5hs1A:
54.7
5fsaB-5hs1A:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE


(Saccharomyces
cerevisiae)
PF00067
(p450)
9 TYR A  72
GLY A  73
LEU A 129
PHE A 134
TYR A 140
GLY A 314
THR A 318
HIS A 381
PHE A 384
None
None
None
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
None
None
0.62A 5fsaB-5hs1A:
54.7
5fsaB-5hs1A:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE


(Saccharomyces
cerevisiae)
PF00067
(p450)
6 TYR A  72
GLY A  73
TYR A 140
ILE A 471
HIS A 381
PHE A 384
None
None
HEM  A 601 (-4.3A)
HEM  A 601 ( 4.9A)
None
None
1.50A 5fsaB-5hs1A:
54.7
5fsaB-5hs1A:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE


(Saccharomyces
cerevisiae)
PF00067
(p450)
9 TYR A  72
LEU A 129
PHE A 134
TYR A 140
PHE A 236
GLY A 314
THR A 318
HIS A 381
PHE A 384
None
None
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
None
None
0.64A 5fsaB-5hs1A:
54.7
5fsaB-5hs1A:
59.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hst POLYKETIDE SYNTHASE
TYPE I


(Bacillus
amyloliquefaciens)
PF14765
(PS-DH)
5 GLY A 222
LEU A 284
PHE A 213
ILE A  59
GLY A  56
None
1.18A 5fsaB-5hstA:
undetectable
5fsaB-5hstA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]


(Candida
albicans)
PF00982
(Glyco_transf_20)
5 GLY A 406
GLN A 409
PHE A 463
ILE A 139
GLY A 167
None
1.10A 5fsaB-5huuA:
undetectable
5fsaB-5huuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)


(Aspergillus
fumigatus)
PF00982
(Glyco_transf_20)
5 GLY A 413
GLN A 416
PHE A 470
ILE A 147
GLY A 175
None
1.10A 5fsaB-5hvmA:
undetectable
5fsaB-5hvmA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)


(Aspergillus
fumigatus)
PF00982
(Glyco_transf_20)
5 GLY A 413
GLN A 416
PHE A 470
ILE A 146
GLY A 175
None
1.16A 5fsaB-5hvoA:
undetectable
5fsaB-5hvoA:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE


([Candida]
glabrata)
PF00067
(p450)
5 LEU A 130
TYR A 127
PHE A 237
GLY A 315
THR A 319
None
1YN  A 602 ( 3.8A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1.26A 5fsaB-5jlcA:
52.0
5fsaB-5jlcA:
62.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE


([Candida]
glabrata)
PF00067
(p450)
5 TYR A  73
GLY A  74
GLY A 316
THR A 319
HIS A 382
1YN  A 602 (-4.9A)
1YN  A 602 ( 3.8A)
HEM  A 601 (-3.5A)
HEM  A 601 ( 3.5A)
1YN  A 602 (-4.2A)
1.04A 5fsaB-5jlcA:
52.0
5fsaB-5jlcA:
62.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE


([Candida]
glabrata)
PF00067
(p450)
10 TYR A  73
GLY A  74
LEU A 130
PHE A 135
TYR A 141
PHE A 237
GLY A 315
THR A 319
HIS A 382
PHE A 385
1YN  A 602 (-4.9A)
1YN  A 602 ( 3.8A)
None
1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 (-4.2A)
1YN  A 602 (-4.8A)
0.68A 5fsaB-5jlcA:
52.0
5fsaB-5jlcA:
62.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE


([Candida]
glabrata)
PF00067
(p450)
6 TYR A  73
GLY A  74
TYR A 141
ILE A 473
HIS A 382
PHE A 385
1YN  A 602 (-4.9A)
1YN  A 602 ( 3.8A)
HEM  A 601 (-4.2A)
HEM  A 601 (-4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-4.8A)
1.39A 5fsaB-5jlcA:
52.0
5fsaB-5jlcA:
62.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK


(Gluconacetobacter
diazotrophicus)
PF00148
(Oxidored_nitro)
PF11844
(DUF3364)
5 TYR B 247
PHE B 106
PHE B  76
ILE B 461
GLY B 227
None
1.29A 5fsaB-5kohB:
undetectable
5fsaB-5kohB:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kov PL-2 SCFV CHAIN

(Mus musculus)
PF07686
(V-set)
5 GLY C1057
PHE C  27
ILE C  51
GLY C  33
HIS C1055
None
1.20A 5fsaB-5kovC:
undetectable
5fsaB-5kovC:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktz VHH 12B

(Camelus
dromedarius)
PF07686
(V-set)
5 GLY 7  15
GLN 7  13
LEU 7  20
GLY 7 115
PHE 7  68
None
1.24A 5fsaB-5ktz7:
undetectable
5fsaB-5ktz7:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE


(Streptomyces
niveus)
PF13649
(Methyltransf_25)
5 GLY A  34
LEU A  66
PHE A  92
GLY A  51
PHE A  61
None
1.02A 5fsaB-5mgzA:
undetectable
5fsaB-5mgzA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ols RHAMNOGALACTURONAN
LYASE


(Bacteroides
thetaiotaomicron)
no annotation 5 GLY A  57
LEU A  47
TYR A  67
PHE A 129
ILE A 144
None
1.07A 5fsaB-5olsA:
undetectable
5fsaB-5olsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN

(Enterovirus E)
PF00073
(Rhv)
5 LEU B 166
PHE C 218
ILE C 215
THR B 119
PHE B 156
None
1.24A 5fsaB-5osnB:
undetectable
5fsaB-5osnB:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN


(Saccharomyces
cerevisiae)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
5 GLY A 135
GLN A 134
LEU A 379
ILE A 292
PHE A 170
None
1.19A 5fsaB-5w3fA:
undetectable
5fsaB-5w3fA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4k DMSP LYASE DDDY

(Acinetobacter
bereziniae)
no annotation 5 GLY A 345
GLN A 348
PHE A 332
ILE A 270
THR A 357
None
1.14A 5fsaB-5y4kA:
undetectable
5fsaB-5y4kA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb3 -

(-)
no annotation 5 TYR A 452
LEU A 376
PHE A 335
PHE A 326
THR A 436
None
1.08A 5fsaB-5zb3A:
undetectable
5fsaB-5zb3A:
undetectable