SIMILAR PATTERNS OF AMINO ACIDS FOR 5FSA_B_X2NB590

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a04 NITRATE/NITRITE
RESPONSE REGULATOR
PROTEIN NARL


(Escherichia
coli)
PF00072
(Response_reg)
PF00196
(GerE)
5 GLY A  21
GLN A  24
LEU A  55
GLY A 126
PHE A  86
None
1.23A 5fsaB-1a04A:
undetectable
5fsaB-1a04A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE


(Bacillus
subtilis)
PF00156
(Pribosyltran)
PF13522
(GATase_6)
5 GLY A  27
GLN A  24
LEU A 180
ILE A 216
HIS A  70
None
1.18A 5fsaB-1ao0A:
undetectable
5fsaB-1ao0A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hc7 PROLYL-TRNA
SYNTHETASE


(Thermus
thermophilus)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1)
5 TYR A 182
GLY A 227
GLN A 225
PHE A 236
GLY A 117
None
1.08A 5fsaB-1hc7A:
0.0
5fsaB-1hc7A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg8 ENDOPOLYGALACTURONAS
E


(Fusarium
verticillioides)
PF00295
(Glyco_hydro_28)
6 TYR A 112
GLY A 109
GLN A 110
LEU A  58
PHE A  71
ILE A  95
None
1.41A 5fsaB-1hg8A:
0.0
5fsaB-1hg8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE


(Thermococcus
litoralis)
PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926)
5 GLY A  52
PHE A 238
PHE A  34
ILE A 241
HIS A  49
None
1.19A 5fsaB-1k1xA:
0.0
5fsaB-1k1xA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6u TRYPTOPHANYL-TRNA
SYNTHETASE


(Homo sapiens)
PF00579
(tRNA-synt_1b)
5 GLY A 265
LEU A 103
PHE A 138
ILE A 136
PHE A  84
None
1.18A 5fsaB-1r6uA:
0.0
5fsaB-1r6uA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw9 CHONDROITIN AC LYASE

(Paenarthrobacter
aurescens)
PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N)
5 GLY A 481
TYR A 626
ILE A 450
GLY A 422
HIS A 376
None
1.16A 5fsaB-1rw9A:
undetectable
5fsaB-1rw9A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s58 B19 PARVOVIRUS
CAPSID


(Primate
erythroparvovirus
1)
PF00740
(Parvo_coat)
5 TYR A 161
GLN A 451
PHE A  99
PHE A 492
ILE A 108
None
1.26A 5fsaB-1s58A:
undetectable
5fsaB-1s58A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT
QUINOLINE
2-OXIDOREDUCTASE
SMALL SUBUNIT


(Pseudomonas
putida)
PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
5 GLY B 509
GLN B 508
LEU B  27
ILE A 121
HIS A 103
MCN  B4921 ( 4.3A)
MCN  B4921 (-3.8A)
None
None
None
1.28A 5fsaB-1t3qB:
2.0
5fsaB-1t3qB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER


(Escherichia
coli)
PF00909
(Ammonium_transp)
5 TYR A 374
GLY A 373
PHE A 215
GLY A 163
THR A 165
None
None
NH3  A 402 (-3.4A)
None
None
1.16A 5fsaB-1u7gA:
undetectable
5fsaB-1u7gA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1


(Methylobacterium
extorquens)
PF01011
(PQQ)
PF13360
(PQQ_2)
5 GLY A 428
GLN A 429
LEU A 129
ILE A 517
GLY A 539
None
None
None
None
PQQ  A1596 (-3.5A)
1.05A 5fsaB-1w6sA:
undetectable
5fsaB-1w6sA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN 1


(Pyrococcus
furiosus)
PF00290
(Trp_syntA)
PF00291
(PALP)
5 GLY A 111
PHE B 274
PHE A  41
GLY B 287
PHE A 125
None
1.22A 5fsaB-1wdwA:
undetectable
5fsaB-1wdwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9e HMG-COA SYNTHASE

(Enterococcus
faecalis)
PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C)
5 TYR A 227
LEU A 281
TYR A 112
ILE A  75
PHE A 314
None
1.18A 5fsaB-1x9eA:
undetectable
5fsaB-1x9eA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahn THAUMATIN-LIKE
PROTEIN


(Prunus avium)
PF00314
(Thaumatin)
5 GLY A 213
LEU A  41
PHE A  31
PHE A   5
GLY A  16
None
1.28A 5fsaB-2ahnA:
undetectable
5fsaB-2ahnA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT


(Pseudomonas
fragi)
PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
5 GLY A 392
LEU A 412
PHE A 447
GLY A 449
THR A 478
None
1.21A 5fsaB-2d3tA:
undetectable
5fsaB-2d3tA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN


(Pyrococcus
horikoshii)
PF00005
(ABC_tran)
PF08402
(TOBE_2)
5 GLY A 291
LEU A 331
PHE A 342
THR A 303
PHE A 266
None
1.23A 5fsaB-2d62A:
undetectable
5fsaB-2d62A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum)
PF12891
(Glyco_hydro_44)
5 TYR A 362
LEU A 355
ILE A 227
GLY A 229
PHE A 381
None
1.12A 5fsaB-2e0pA:
undetectable
5fsaB-2e0pA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
5 GLY A 374
LEU A 203
ILE A 189
GLY A 190
THR A 172
None
None
None
None
FAD  A1002 (-4.1A)
1.18A 5fsaB-2e5vA:
undetectable
5fsaB-2e5vA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9y CARBAMATE KINASE

(Aeropyrum
pernix)
PF00696
(AA_kinase)
5 GLY A 196
GLN A  86
LEU A 232
GLY A 296
THR A 236
None
1.13A 5fsaB-2e9yA:
undetectable
5fsaB-2e9yA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis)
PF01274
(Malate_synthase)
5 TYR A 555
GLN A 557
ILE A 639
THR A 517
HIS A 551
None
1.23A 5fsaB-2gq3A:
undetectable
5fsaB-2gq3A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI


(Haemophilus
haemolyticus)
PF00145
(DNA_methylase)
5 GLY A 158
LEU A 251
TYR A 299
ILE A 207
GLY A 264
None
1.22A 5fsaB-2i9kA:
undetectable
5fsaB-2i9kA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ich PUTATIVE ATTH

(Nitrosomonas
europaea)
PF07143
(CrtC)
PF17186
(Lipocalin_9)
5 GLY A 171
PHE A 333
GLY A 343
THR A  53
PHE A 244
None
None
None
None
NHE  A   1 (-3.6A)
1.28A 5fsaB-2ichA:
undetectable
5fsaB-2ichA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odl ADHESIN

(Haemophilus
influenzae)
PF05860
(Haemagg_act)
5 GLY A 166
GLN A 145
LEU A 233
GLY A 216
THR A 171
None
1.19A 5fsaB-2odlA:
undetectable
5fsaB-2odlA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p24 H-2 CLASS II
HISTOCOMPATIBILITY
ANTIGEN, A-U ALPHA
CHAIN
H-2 CLASS II
HISTOCOMPATIBILITY
ANTIGEN, A-U BETA
CHAIN


(Mus musculus)
PF00969
(MHC_II_beta)
PF00993
(MHC_II_alpha)
PF07654
(C1-set)
5 GLY B   1
TYR A 133
PHE A 138
ILE A 106
GLY B 251
None
1.29A 5fsaB-2p24B:
undetectable
5fsaB-2p24B:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1


(Saccharomyces
cerevisiae)
PF00393
(6PGD)
PF03446
(NAD_binding_2)
5 GLY A 129
PHE A 394
TYR A 379
PHE A 371
HIS A 185
FLC  A 502 ( 4.5A)
None
None
None
FLC  A 502 (-4.5A)
1.11A 5fsaB-2p4qA:
undetectable
5fsaB-2p4qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qiw PEP PHOSPHONOMUTASE

(Corynebacterium
glutamicum)
PF13714
(PEP_mutase)
5 GLY A 228
LEU A  23
PHE A  11
ILE A 101
GLY A 108
GOL  A 259 (-3.6A)
None
None
None
None
1.04A 5fsaB-2qiwA:
undetectable
5fsaB-2qiwA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjp CYTOCHROME B

(Rhodobacter
sphaeroides)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
5 GLY A 152
GLN A 153
LEU A 181
ILE A 169
GLY A 167
None
1.25A 5fsaB-2qjpA:
0.0
5fsaB-2qjpA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmi PBP RELATED
BETA-LACTAMASE


(Pyrococcus
abyssi)
PF00144
(Beta-lactamase)
PF13969
(Pab87_oct)
5 TYR A 284
ILE A 215
GLY A 307
THR A 310
HIS A 302
None
1.29A 5fsaB-2qmiA:
undetectable
5fsaB-2qmiA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rau PUTATIVE ESTERASE

(Sulfolobus
solfataricus)
PF12146
(Hydrolase_4)
5 GLY A 154
LEU A 329
ILE A 217
GLY A 211
PHE A 304
None
None
CA  A 354 ( 3.9A)
None
None
1.20A 5fsaB-2rauA:
undetectable
5fsaB-2rauA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6o THIOREDOXIN
GLUTATHIONE
REDUCTASE


(Schistosoma
mansoni)
PF00462
(Glutaredoxin)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 TYR A 212
GLY A 151
PHE A 474
ILE A 547
GLY A 545
None
1.28A 5fsaB-2v6oA:
undetectable
5fsaB-2v6oA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8j PECTATE LYASE

(Yersinia
enterocolitica)
PF06917
(Pectate_lyase_2)
5 LEU A 131
TYR A 135
PHE A 156
THR A 169
PHE A 513
None
1.28A 5fsaB-2v8jA:
undetectable
5fsaB-2v8jA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vtc CEL61B

(Trichoderma
reesei)
PF03443
(Glyco_hydro_61)
5 PHE A 211
TYR A 214
ILE A 123
GLY A  92
HIS A   1
None
None
None
None
NI  A1231 (-3.2A)
1.16A 5fsaB-2vtcA:
undetectable
5fsaB-2vtcA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING


(Geobacillus
stearothermophilus)
PF00393
(6PGD)
PF03446
(NAD_binding_2)
5 GLY A 129
PHE A 394
TYR A 379
PHE A 371
HIS A 185
6PG  A1470 (-3.7A)
None
None
None
6PG  A1470 (-4.5A)
1.10A 5fsaB-2w8zA:
undetectable
5fsaB-2w8zA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE


(Pseudomonas
aeruginosa)
PF01370
(Epimerase)
5 TYR A  54
PHE A 333
GLY A 194
THR A 192
HIS A  26
None
1.10A 5fsaB-2x4gA:
undetectable
5fsaB-2x4gA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1


(Homo sapiens)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
5 GLY A 676
GLN A 675
LEU A 686
GLY A 920
PHE A 699
None
0.90A 5fsaB-2yd0A:
undetectable
5fsaB-2yd0A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING


(Klebsiella
pneumoniae)
PF00393
(6PGD)
PF03446
(NAD_binding_2)
5 GLY A 129
PHE A 393
TYR A 378
PHE A 370
HIS A 186
None
1.16A 5fsaB-2zygA:
undetectable
5fsaB-2zygA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
5 LEU A 463
PHE A 143
ILE A 173
GLY A 225
HIS A 396
None
None
None
None
C2O  A 702 ( 3.3A)
1.23A 5fsaB-3aw5A:
undetectable
5fsaB-3aw5A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb7 INTERPAIN A

(Prevotella
intermedia)
PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69)
5 GLY A 292
LEU A 163
TYR A 199
PHE A 259
GLY A 258
None
1.19A 5fsaB-3bb7A:
undetectable
5fsaB-3bb7A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be8 NEUROLIGIN-4,
X-LINKED


(Homo sapiens)
PF00135
(COesterase)
5 LEU A 132
PHE A 128
ILE A 172
GLY A 174
HIS A 113
None
None
None
PO4  A 623 ( 3.6A)
None
1.25A 5fsaB-3be8A:
undetectable
5fsaB-3be8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans)
PF00149
(Metallophos)
5 GLN A 125
LEU A 177
ILE A 220
GLY A 247
THR A  33
None
1.14A 5fsaB-3c9fA:
undetectable
5fsaB-3c9fA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9t L-TYROSINE
DECARBOXYLASE MFNA


(Methanocaldococcus
jannaschii)
PF00282
(Pyridoxal_deC)
5 GLY A 288
LEU A 298
PHE A 216
ILE A 214
GLY A 211
None
1.23A 5fsaB-3f9tA:
undetectable
5fsaB-3f9tA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcj NITROALKANE OXIDASE

(Fusarium
oxysporum)
PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N)
5 GLY A 267
GLN A 266
ILE A 285
GLY A 281
THR A 358
None
0.95A 5fsaB-3fcjA:
undetectable
5fsaB-3fcjA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19


(Rhodobacter
sphaeroides)
PF01244
(Peptidase_M19)
6 GLY A 313
LEU A  38
PHE A  53
PHE A  48
ILE A 133
GLY A  51
None
1.41A 5fsaB-3fdgA:
undetectable
5fsaB-3fdgA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2


(Mus musculus)
PF04916
(Phospholip_B)
5 GLY A 377
GLN A 408
LEU A 168
GLY A 218
PHE A 163
None
1.15A 5fsaB-3fgwA:
undetectable
5fsaB-3fgwA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw6 CELLULASE

(uncultured
bacterium)
PF12891
(Glyco_hydro_44)
5 GLY A 272
GLN A 280
LEU A 310
GLY A 250
PHE A 325
None
1.06A 5fsaB-3fw6A:
undetectable
5fsaB-3fw6A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hy8 PYRIDOXINE-5'-PHOSPH
ATE OXIDASE


(Homo sapiens)
PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C)
5 GLY A 144
GLN A 214
LEU A 149
TYR A 157
PHE A 109
None
None
None
PO4  A 360 (-3.7A)
None
1.24A 5fsaB-3hy8A:
undetectable
5fsaB-3hy8A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE


(Cupriavidus
pinatubonensis)
PF00465
(Fe-ADH)
5 GLY A 249
LEU A 166
GLY A  96
THR A 100
HIS A  71
None
None
None
None
NAD  A 400 (-3.4A)
1.24A 5fsaB-3jzdA:
undetectable
5fsaB-3jzdA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mda DNA POLYMERASE
LAMBDA


(Homo sapiens)
PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm)
5 GLY A 508
LEU A 532
GLY A 524
THR A 522
PHE A 560
None
1.25A 5fsaB-3mdaA:
undetectable
5fsaB-3mdaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0h GLUTATHIONE
REDUCTASE


(Bartonella
henselae)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 TYR A  99
GLY A  40
PHE A 345
ILE A 414
GLY A 412
None
1.07A 5fsaB-3o0hA:
undetectable
5fsaB-3o0hA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B


(Pseudomonas
aeruginosa)
PF00115
(COX1)
5 GLY B 408
GLN B 411
PHE B 261
ILE B 254
GLY B 257
None
1.04A 5fsaB-3o0rB:
undetectable
5fsaB-3o0rB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS


(Aspergillus
oryzae)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 GLY A 402
LEU A  97
GLY A 211
THR A 203
PHE A 512
None
FAY  A 600 (-4.9A)
None
None
FAY  A 600 (-3.6A)
1.25A 5fsaB-3q9tA:
undetectable
5fsaB-3q9tA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1


(Homo sapiens)
PF11838
(ERAP1_C)
5 GLY A 676
GLN A 675
LEU A 686
GLY A 920
PHE A 699
None
0.94A 5fsaB-3rjoA:
undetectable
5fsaB-3rjoA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M


(Escherichia
coli)
no annotation 5 GLY M 413
GLN M 416
LEU M 272
ILE M  83
GLY M  85
None
1.19A 5fsaB-3rkoM:
undetectable
5fsaB-3rkoM:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tnl SHIKIMATE
DEHYDROGENASE


(Listeria
monocytogenes)
PF08501
(Shikimate_dh_N)
5 GLY A 269
GLN A 268
LEU A  15
PHE A  48
PHE A  36
None
SKM  A 293 (-3.3A)
None
None
None
1.22A 5fsaB-3tnlA:
undetectable
5fsaB-3tnlA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1h 3-ISOPROPYLMALATE
DEHYDROGENASE


(Bacillus sp.
(in: Bacteria))
PF00180
(Iso_dh)
5 GLY A 309
TYR A  40
GLY A  72
THR A 296
PHE A  36
None
0.95A 5fsaB-3u1hA:
undetectable
5fsaB-3u1hA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsy SORTILIN-RELATED
RECEPTOR


(Homo sapiens)
PF15901
(Sortilin_C)
PF15902
(Sortilin-Vps10)
5 GLY A 238
LEU A 231
PHE A 284
ILE A 293
THR A 263
None
1.11A 5fsaB-3wsyA:
undetectable
5fsaB-3wsyA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP


(Corynebacterium
glutamicum)
PF02028
(BCCT)
5 PHE A 380
TYR A 197
GLY A 249
THR A 522
PHE A 110
None
1.22A 5fsaB-4ainA:
undetectable
5fsaB-4ainA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bob ERPP PROTEIN

(Borreliella
burgdorferi)
PF02471
(OspE)
5 LEU A  52
PHE A  77
ILE A 121
GLY A 138
THR A 150
None
1.18A 5fsaB-4bobA:
undetectable
5fsaB-4bobA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans)
PF00232
(Glyco_hydro_1)
5 GLY A 261
ILE A 165
GLY A 175
THR A 181
PHE A 291
None
1.28A 5fsaB-4ha4A:
undetectable
5fsaB-4ha4A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4b PYLD

(Methanosarcina
barkeri)
no annotation 5 LEU A 101
PHE A  63
PHE A 108
THR A 125
PHE A  76
None
0TF  A 904 (-3.8A)
None
NAI  A 901 (-3.4A)
None
1.18A 5fsaB-4j4bA:
undetectable
5fsaB-4j4bA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8p FLAVODOXIN

(Bacteroides
uniformis)
PF12682
(Flavodoxin_4)
5 GLY A  36
PHE A 126
TYR A  99
PHE A 120
PHE A  53
GOL  A 206 ( 3.3A)
None
GOL  A 203 (-4.7A)
None
None
1.22A 5fsaB-4j8pA:
undetectable
5fsaB-4j8pA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcs ENOYL-COA
HYDRATASE/ISOMERASE


(Cupriavidus
metallidurans)
PF00378
(ECH_1)
5 GLY A  13
LEU A 115
PHE A  26
ILE A  83
GLY A  86
None
1.18A 5fsaB-4jcsA:
undetectable
5fsaB-4jcsA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE


(Agaricus
bisporus)
PF00264
(Tyrosinase)
5 GLY A 135
LEU A 205
ILE A 263
GLY A 265
THR A 268
None
1.27A 5fsaB-4ouaA:
0.4
5fsaB-4ouaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psw HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT
HISTONE
ACETYLTRANSFERASE
TYPE B SUBUNIT 2
HISTONE H4 TYPE VIII


(Ophiophagus
hannah;
Saccharomyces
cerevisiae)
PF00400
(WD40)
PF00583
(Acetyltransf_1)
PF10394
(Hat1_N)
PF12265
(CAF1C_H4-bd)
no annotation
5 TYR A 194
GLY C  11
LEU B 278
PHE B 303
GLY B 309
None
1.23A 5fsaB-4pswA:
undetectable
5fsaB-4pswA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN


(Zea mays)
PF00171
(Aldedh)
5 GLY A 270
GLN A 423
LEU A 343
PHE A 352
GLY A 370
None
1.25A 5fsaB-4pxnA:
undetectable
5fsaB-4pxnA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlv ADP-RIBOSYLATING
TOXIN CARDS


(Mycoplasma
pneumoniae)
PF02917
(Pertussis_S1)
5 LEU A 403
ILE A 280
GLY A 279
THR A 285
PHE A 315
None
1.26A 5fsaB-4tlvA:
undetectable
5fsaB-4tlvA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpn PUTATIVE P450-LIKE
PROTEIN


(Streptomyces
scabiei)
PF00067
(p450)
5 GLY A 226
LEU A 239
TYR A 199
GLY A 156
THR A 215
None
1.28A 5fsaB-4tpnA:
26.6
5fsaB-4tpnA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy6 HISTIDINE-SPECIFIC
METHYLTRANSFERASE
EGTD


(Mycolicibacterium
smegmatis)
PF10017
(Methyltransf_33)
5 GLY A  25
LEU A 167
PHE A 159
PHE A 142
GLY A  86
None
None
None
SAH  A 801 (-3.4A)
SAH  A 801 (-3.0A)
1.01A 5fsaB-4uy6A:
undetectable
5fsaB-4uy6A:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uym 14-ALPHA STEROL
DEMETHYLASE


(Aspergillus
fumigatus)
PF00067
(p450)
5 LEU A 125
PHE A 130
TYR A 136
PHE A 229
HIS A 374
None
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
None
None
1.20A 5fsaB-4uymA:
51.5
5fsaB-4uymA:
50.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uym 14-ALPHA STEROL
DEMETHYLASE


(Aspergillus
fumigatus)
PF00067
(p450)
6 TYR A  68
GLY A  69
LEU A 125
PHE A 130
TYR A 136
HIS A 374
None
None
None
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
None
1.01A 5fsaB-4uymA:
51.5
5fsaB-4uymA:
50.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs ECU04_1440 PROTEIN
SIMILARITY TO
HELICASE MOT1


(Encephalitozoon
cuniculi)
PF00352
(TBP)
no annotation
5 GLY C  93
GLN C  95
LEU D 104
PHE C 213
ILE C 293
None
1.10A 5fsaB-4wzsC:
undetectable
5fsaB-4wzsC:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Rhodobacter
sphaeroides)
PF03480
(DctP)
5 GLY A 192
PHE A 131
PHE A  93
ILE A 137
THR A  78
None
1.27A 5fsaB-4x8rA:
undetectable
5fsaB-4x8rA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG


(Bacillus
subtilis)
PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C)
5 LEU A 302
TYR A 115
PHE A 303
ILE A  78
PHE A 334
None
1.04A 5fsaB-4yxtA:
undetectable
5fsaB-4yxtA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT


(Azospira oryzae)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
5 TYR A 875
GLY A 876
GLN A 485
ILE A 395
PHE A 737
None
1.24A 5fsaB-5chcA:
undetectable
5fsaB-5chcA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfw SINGLE CHAIN FV
FRAGMENT


(Mus musculus)
PF07686
(V-set)
5 TYR H 602
GLN H 604
ILE H 308
THR H 124
PHE H 753
None
1.29A 5fsaB-5dfwH:
undetectable
5fsaB-5dfwH:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee0 OBG-LIKE ATPASE 1

(Oryza sativa)
PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C)
5 GLY A  19
LEU A  90
PHE A 123
THR A 258
HIS A 303
None
1.25A 5fsaB-5ee0A:
undetectable
5fsaB-5ee0A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey7 FRUCTOKINASE

(Vibrio cholerae)
PF00294
(PfkB)
5 GLY A 307
LEU A  80
PHE A  63
GLY A  65
PHE A  75
NA  A 401 (-4.3A)
None
None
None
None
1.25A 5fsaB-5ey7A:
undetectable
5fsaB-5ey7A:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE


(Saccharomyces
cerevisiae)
PF00067
(p450)
5 TYR A  72
GLY A  73
GLY A 315
THR A 318
HIS A 381
None
None
HEM  A 601 (-3.5A)
HEM  A 601 (-3.4A)
None
0.86A 5fsaB-5hs1A:
54.7
5fsaB-5hs1A:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE


(Saccharomyces
cerevisiae)
PF00067
(p450)
9 TYR A  72
GLY A  73
LEU A 129
PHE A 134
TYR A 140
GLY A 314
THR A 318
HIS A 381
PHE A 384
None
None
None
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
None
None
0.62A 5fsaB-5hs1A:
54.7
5fsaB-5hs1A:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE


(Saccharomyces
cerevisiae)
PF00067
(p450)
6 TYR A  72
GLY A  73
TYR A 140
ILE A 471
HIS A 381
PHE A 384
None
None
HEM  A 601 (-4.3A)
HEM  A 601 ( 4.9A)
None
None
1.50A 5fsaB-5hs1A:
54.7
5fsaB-5hs1A:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE


(Saccharomyces
cerevisiae)
PF00067
(p450)
9 TYR A  72
LEU A 129
PHE A 134
TYR A 140
PHE A 236
GLY A 314
THR A 318
HIS A 381
PHE A 384
None
None
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
None
None
0.64A 5fsaB-5hs1A:
54.7
5fsaB-5hs1A:
59.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hst POLYKETIDE SYNTHASE
TYPE I


(Bacillus
amyloliquefaciens)
PF14765
(PS-DH)
5 GLY A 222
LEU A 284
PHE A 213
ILE A  59
GLY A  56
None
1.18A 5fsaB-5hstA:
undetectable
5fsaB-5hstA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]


(Candida
albicans)
PF00982
(Glyco_transf_20)
5 GLY A 406
GLN A 409
PHE A 463
ILE A 139
GLY A 167
None
1.10A 5fsaB-5huuA:
undetectable
5fsaB-5huuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)


(Aspergillus
fumigatus)
PF00982
(Glyco_transf_20)
5 GLY A 413
GLN A 416
PHE A 470
ILE A 147
GLY A 175
None
1.10A 5fsaB-5hvmA:
undetectable
5fsaB-5hvmA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)


(Aspergillus
fumigatus)
PF00982
(Glyco_transf_20)
5 GLY A 413
GLN A 416
PHE A 470
ILE A 146
GLY A 175
None
1.16A 5fsaB-5hvoA:
undetectable
5fsaB-5hvoA:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE


([Candida]
glabrata)
PF00067
(p450)
5 LEU A 130
TYR A 127
PHE A 237
GLY A 315
THR A 319
None
1YN  A 602 ( 3.8A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1.26A 5fsaB-5jlcA:
52.0
5fsaB-5jlcA:
62.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE


([Candida]
glabrata)
PF00067
(p450)
5 TYR A  73
GLY A  74
GLY A 316
THR A 319
HIS A 382
1YN  A 602 (-4.9A)
1YN  A 602 ( 3.8A)
HEM  A 601 (-3.5A)
HEM  A 601 ( 3.5A)
1YN  A 602 (-4.2A)
1.04A 5fsaB-5jlcA:
52.0
5fsaB-5jlcA:
62.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE


([Candida]
glabrata)
PF00067
(p450)
10 TYR A  73
GLY A  74
LEU A 130
PHE A 135
TYR A 141
PHE A 237
GLY A 315
THR A 319
HIS A 382
PHE A 385
1YN  A 602 (-4.9A)
1YN  A 602 ( 3.8A)
None
1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 (-4.2A)
1YN  A 602 (-4.8A)
0.68A 5fsaB-5jlcA:
52.0
5fsaB-5jlcA:
62.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE


([Candida]
glabrata)
PF00067
(p450)
6 TYR A  73
GLY A  74
TYR A 141
ILE A 473
HIS A 382
PHE A 385
1YN  A 602 (-4.9A)
1YN  A 602 ( 3.8A)
HEM  A 601 (-4.2A)
HEM  A 601 (-4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-4.8A)
1.39A 5fsaB-5jlcA:
52.0
5fsaB-5jlcA:
62.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK


(Gluconacetobacter
diazotrophicus)
PF00148
(Oxidored_nitro)
PF11844
(DUF3364)
5 TYR B 247
PHE B 106
PHE B  76
ILE B 461
GLY B 227
None
1.29A 5fsaB-5kohB:
undetectable
5fsaB-5kohB:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kov PL-2 SCFV CHAIN

(Mus musculus)
PF07686
(V-set)
5 GLY C1057
PHE C  27
ILE C  51
GLY C  33
HIS C1055
None
1.20A 5fsaB-5kovC:
undetectable
5fsaB-5kovC:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktz VHH 12B

(Camelus
dromedarius)
PF07686
(V-set)
5 GLY 7  15
GLN 7  13
LEU 7  20
GLY 7 115
PHE 7  68
None
1.24A 5fsaB-5ktz7:
undetectable
5fsaB-5ktz7:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE


(Streptomyces
niveus)
PF13649
(Methyltransf_25)
5 GLY A  34
LEU A  66
PHE A  92
GLY A  51
PHE A  61
None
1.02A 5fsaB-5mgzA:
undetectable
5fsaB-5mgzA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ols RHAMNOGALACTURONAN
LYASE


(Bacteroides
thetaiotaomicron)
no annotation 5 GLY A  57
LEU A  47
TYR A  67
PHE A 129
ILE A 144
None
1.07A 5fsaB-5olsA:
undetectable
5fsaB-5olsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN

(Enterovirus E)
PF00073
(Rhv)
5 LEU B 166
PHE C 218
ILE C 215
THR B 119
PHE B 156
None
1.24A 5fsaB-5osnB:
undetectable
5fsaB-5osnB:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN


(Saccharomyces
cerevisiae)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
5 GLY A 135
GLN A 134
LEU A 379
ILE A 292
PHE A 170
None
1.19A 5fsaB-5w3fA:
undetectable
5fsaB-5w3fA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4k DMSP LYASE DDDY

(Acinetobacter
bereziniae)
no annotation 5 GLY A 345
GLN A 348
PHE A 332
ILE A 270
THR A 357
None
1.14A 5fsaB-5y4kA:
undetectable
5fsaB-5y4kA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb3 -

(-)
no annotation 5 TYR A 452
LEU A 376
PHE A 335
PHE A 326
THR A 436
None
1.08A 5fsaB-5zb3A:
undetectable
5fsaB-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
3 PRO A 499
LEU A 643
SER A 635
None
0.80A 5fsaB-1bf2A:
0.0
5fsaB-1bf2A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsk ANTIBODY HEAVY CHAIN
FAB


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 PRO C  86
LEU C  11
SER C  17
None
0.55A 5fsaB-1fskC:
0.0
5fsaB-1fskC:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu1 GAMMA1-ADAPTIN

(Homo sapiens)
PF02883
(Alpha_adaptinC2)
3 PRO A 765
LEU A 798
SER A 768
None
0.78A 5fsaB-1iu1A:
undetectable
5fsaB-1iu1A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyb RIBONUCLEASE

(Nicotiana
glutinosa)
PF00445
(Ribonuclease_T2)
3 PRO A  14
LEU A 123
SER A  34
None
0.62A 5fsaB-1iybA:
0.0
5fsaB-1iybA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyb RIBONUCLEASE

(Nicotiana
glutinosa)
PF00445
(Ribonuclease_T2)
3 PRO A  14
LEU A 127
SER A  34
None
0.77A 5fsaB-1iybA:
0.0
5fsaB-1iybA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeq KU70

(Homo sapiens)
PF02037
(SAP)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N)
3 PRO A 370
LEU A 413
SER A 383
None
0.72A 5fsaB-1jeqA:
0.0
5fsaB-1jeqA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy5 CALSEPRRP

(Calystegia
sepium)
PF00445
(Ribonuclease_T2)
3 PRO A 199
LEU A 204
SER A 172
None
0.72A 5fsaB-1jy5A:
0.0
5fsaB-1jy5A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzk HEROIN ESTERASE

(Rhodococcus sp.)
PF07859
(Abhydrolase_3)
3 PRO A 180
LEU A  83
SER A 152
None
0.84A 5fsaB-1lzkA:
0.0
5fsaB-1lzkA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mh6 BLEOMYCIN RESISTANCE
PROTEIN


(Klebsiella
pneumoniae)
no annotation 3 PRO A 309
LEU A 245
SER A 216
None
0.73A 5fsaB-1mh6A:
undetectable
5fsaB-1mh6A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n9b BETA-LACTAMASE SHV-2

(Klebsiella
pneumoniae)
PF13354
(Beta-lactamase2)
3 PRO A 107
LEU A 122
SER A 130
None
None
EPE  A 400 (-2.5A)
0.78A 5fsaB-1n9bA:
0.0
5fsaB-1n9bA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum)
PF01425
(Amidase)
3 PRO A 115
LEU A 119
SER A 355
None
0.84A 5fsaB-1ocmA:
undetectable
5fsaB-1ocmA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT


(Propionibacterium
freudenreichii)
PF01039
(Carboxyl_trans)
3 PRO A 372
LEU A 317
SER A 340
None
0.58A 5fsaB-1on9A:
undetectable
5fsaB-1on9A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q47 SEMAPHORIN 3A

(Mus musculus)
PF01403
(Sema)
3 PRO A 415
LEU A 308
SER A 294
None
0.67A 5fsaB-1q47A:
undetectable
5fsaB-1q47A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE


(Rhodotorula
toruloides)
PF00221
(Lyase_aromatic)
3 PRO A 369
LEU A 335
SER A 310
None
0.82A 5fsaB-1t6pA:
1.5
5fsaB-1t6pA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqv THIAMINE
MONOPHOSPHATE KINASE


(Aquifex
aeolicus)
PF00586
(AIRS)
3 PRO A  57
LEU A  86
SER A  95
None
0.75A 5fsaB-1vqvA:
undetectable
5fsaB-1vqvA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI


(Escherichia
coli)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
3 PRO A 678
LEU A 340
SER A 268
None
0.73A 5fsaB-1we5A:
undetectable
5fsaB-1we5A:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis)
PF00067
(p450)
3 PRO A 178
LEU A  29
SER A 431
None
0.77A 5fsaB-1x8vA:
34.6
5fsaB-1x8vA:
30.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aey FRUCTAN
1-EXOHYDROLASE IIA


(Cichorium
intybus)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
3 PRO A 253
LEU A 266
SER A 258
None
0.57A 5fsaB-2aeyA:
undetectable
5fsaB-2aeyA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5y YKUV PROTEIN

(Bacillus
subtilis)
PF00578
(AhpC-TSA)
3 PRO A  70
LEU A  17
SER A  98
None
0.80A 5fsaB-2b5yA:
undetectable
5fsaB-2b5yA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhz RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR (GEF)-LIKE 1


(Homo sapiens)
no annotation 3 PRO A  17
LEU A  58
SER A  94
None
0.82A 5fsaB-2dhzA:
undetectable
5fsaB-2dhzA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djk PROTEIN
DISULFIDE-ISOMERASE


(Humicola
insolens)
PF13848
(Thioredoxin_6)
3 PRO A 120
LEU A  72
SER A 124
None
0.85A 5fsaB-2djkA:
undetectable
5fsaB-2djkA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9x DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2


(Homo sapiens)
PF05916
(Sld5)
3 PRO B  19
LEU B  33
SER B  22
None
0.79A 5fsaB-2e9xB:
undetectable
5fsaB-2e9xB:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)


(Arabidopsis
thaliana)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc)
3 PRO A 287
LEU A 189
SER A 183
None
0.82A 5fsaB-2fgeA:
undetectable
5fsaB-2fgeA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk0 D-PSICOSE
3-EPIMERASE


(Agrobacterium
tumefaciens)
PF01261
(AP_endonuc_2)
3 PRO A  68
LEU A 147
SER A 110
PRO  A  68 ( 1.1A)
LEU  A 147 ( 0.6A)
SER  A 110 ( 0.0A)
0.65A 5fsaB-2hk0A:
undetectable
5fsaB-2hk0A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3u YBBR FAMILY PROTEIN

(Desulfitobacterium
hafniense)
no annotation 3 PRO A  78
LEU A  24
SER A  28
None
0.76A 5fsaB-2l3uA:
undetectable
5fsaB-2l3uA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens)
PF01979
(Amidohydro_1)
3 PRO A 374
LEU A 409
SER A 439
None
0.76A 5fsaB-2oodA:
undetectable
5fsaB-2oodA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq3 MANNITOL-SPECIFIC
CRYPTIC
PHOSPHOTRANSFERASE
ENZYME IIA COMPONENT


(Escherichia
coli)
PF00359
(PTS_EIIA_2)
3 PRO A   8
LEU A 103
SER A  31
None
0.81A 5fsaB-2oq3A:
undetectable
5fsaB-2oq3A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnk 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE


(Homo sapiens)
PF06052
(3-HAO)
3 PRO A  86
LEU A 172
SER A 176
None
0.76A 5fsaB-2qnkA:
undetectable
5fsaB-2qnkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vak SIGMA A

(Avian
orthoreovirus)
PF03084
(Sigma_1_2)
3 PRO A  86
LEU A  80
SER A  20
None
0.68A 5fsaB-2vakA:
undetectable
5fsaB-2vakA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL


(Homo sapiens)
PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
3 PRO A 339
LEU A 305
SER A 342
None
0.84A 5fsaB-2xijA:
undetectable
5fsaB-2xijA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv5 YJEQ PROTEIN

(Aquifex
aeolicus)
PF03193
(RsgA_GTPase)
3 PRO A  92
LEU A  99
SER A 174
None
None
GDP  A1001 ( 4.1A)
0.85A 5fsaB-2yv5A:
undetectable
5fsaB-2yv5A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP


(Escherichia
coli)
PF02395
(Peptidase_S6)
3 PRO A 661
LEU A 752
SER A 689
None
0.74A 5fsaB-3ak5A:
undetectable
5fsaB-3ak5A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay5 CYCLIN-D1-BINDING
PROTEIN 1


(Homo sapiens)
PF13324
(GCIP)
3 PRO A  17
LEU A  77
SER A  81
None
0.69A 5fsaB-3ay5A:
undetectable
5fsaB-3ay5A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btp SINGLE-STRAND
DNA-BINDING PROTEIN


(Agrobacterium
fabrum)
PF07229
(VirE2)
3 PRO A 161
LEU A 264
SER A 258
None
0.78A 5fsaB-3btpA:
undetectable
5fsaB-3btpA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE


(Homo sapiens)
PF00305
(Lipoxygenase)
3 PRO A 558
LEU A 296
SER A 345
None
0.60A 5fsaB-3d3lA:
1.9
5fsaB-3d3lA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eay SENTRIN-SPECIFIC
PROTEASE 7


(Homo sapiens)
PF02902
(Peptidase_C48)
3 PRO A 788
LEU A 722
SER A 739
None
0.82A 5fsaB-3eayA:
undetectable
5fsaB-3eayA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fle SE_1780 PROTEIN

(Staphylococcus
epidermidis)
PF06028
(DUF915)
3 PRO A 164
LEU A  94
SER A 127
None
0.82A 5fsaB-3fleA:
undetectable
5fsaB-3fleA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fm0 PROTEIN CIAO1

(Homo sapiens)
PF00400
(WD40)
3 PRO A 160
LEU A 263
SER A 205
None
0.78A 5fsaB-3fm0A:
undetectable
5fsaB-3fm0A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE


(Vibrio cholerae)
PF00342
(PGI)
3 PRO A 407
LEU A 170
SER A 410
None
0.80A 5fsaB-3hjbA:
undetectable
5fsaB-3hjbA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3


(Thermus
thermophilus)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4)
3 PRO 3 551
LEU 3 345
SER 3 557
None
0.74A 5fsaB-3i9v3:
undetectable
5fsaB-3i9v3:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON


(Thermococcus
onnurineus)
PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32)
3 PRO A 581
LEU A 446
SER A 550
None
0.68A 5fsaB-3k1jA:
undetectable
5fsaB-3k1jA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwb PREPHENATE
DEHYDRATASE


(Paenarthrobacter
aurescens)
PF00800
(PDT)
PF01842
(ACT)
3 PRO A 191
LEU A 183
SER A 276
None
0.82A 5fsaB-3mwbA:
undetectable
5fsaB-3mwbA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT


(Allochromatium
vinosum)
PF00374
(NiFeSe_Hases)
3 PRO B1225
LEU B1228
SER B1232
None
0.81A 5fsaB-3myrB:
1.0
5fsaB-3myrB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ol2 SEMAPHORIN-4D

(Homo sapiens)
PF00047
(ig)
PF01403
(Sema)
PF01437
(PSI)
3 PRO A 406
LEU A 293
SER A 282
None
0.76A 5fsaB-3ol2A:
undetectable
5fsaB-3ol2A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN


(Homo sapiens)
PF04389
(Peptidase_M28)
3 PRO X 320
LEU X 339
SER X 323
None
0.61A 5fsaB-3pb9X:
undetectable
5fsaB-3pb9X:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE
REGULATORY PROTEIN


(Xenopus laevis)
no annotation 3 PRO B 453
LEU B 406
SER B 430
None
0.81A 5fsaB-3w0lB:
0.4
5fsaB-3w0lB:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whe HEMAGGLUTININ

(Influenza A
virus)
PF00509
(Hemagglutinin)
3 PRO A 215
LEU A 194
SER A 199
None
0.74A 5fsaB-3wheA:
undetectable
5fsaB-3wheA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 PRO H  82
LEU H  11
SER H  17
None
0.75A 5fsaB-4ag4H:
undetectable
5fsaB-4ag4H:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5q GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN D


(Phanerochaete
chrysosporium)
PF03443
(Glyco_hydro_61)
3 PRO A  10
LEU A 141
SER A  61
None
0.81A 5fsaB-4b5qA:
undetectable
5fsaB-4b5qA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blf SINGLE-STRAND
DNA-BINDING PROTEIN


(Agrobacterium
tumefaciens)
PF07229
(VirE2)
3 PRO A 161
LEU A 264
SER A 258
None
0.79A 5fsaB-4blfA:
undetectable
5fsaB-4blfA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin)
3 PRO B 363
LEU B  92
SER B 413
None
0.76A 5fsaB-4cakB:
undetectable
5fsaB-4cakB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe)
PF11715
(Nup160)
3 PRO B  96
LEU B 673
SER B  92
None
0.79A 5fsaB-4fhnB:
undetectable
5fsaB-4fhnB:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbr BETA-2 ADRENERGIC
RECEPTOR


(Homo sapiens)
PF00001
(7tm_1)
3 PRO A 211
LEU A 259
SER A 207
None
None
CAU  A 500 (-4.1A)
0.82A 5fsaB-4gbrA:
0.0
5fsaB-4gbrA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq1 NUP37

(Schizosaccharomyces
pombe)
PF00400
(WD40)
3 PRO A 195
LEU A 283
SER A 264
None
0.83A 5fsaB-4gq1A:
undetectable
5fsaB-4gq1A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz8 SEMAPHORIN-3A

(Mus musculus)
PF01403
(Sema)
3 PRO A 415
LEU A 308
SER A 294
None
0.70A 5fsaB-4gz8A:
undetectable
5fsaB-4gz8A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE


(Burkholderia
lata)
PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C)
3 PRO A 169
LEU A 162
SER A 137
None
0.68A 5fsaB-4hmwA:
undetectable
5fsaB-4hmwA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kys THIAMINE
PYRIDINYLASE I


(Clostridium
botulinum)
PF01547
(SBP_bac_1)
3 PRO A 246
LEU A 186
SER A 251
None
0.54A 5fsaB-4kysA:
undetectable
5fsaB-4kysA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l15 FIDGETIN-LIKE
PROTEIN 1


(Caenorhabditis
elegans)
PF00004
(AAA)
PF09336
(Vps4_C)
3 PRO A 357
LEU A 321
SER A 519
None
0.70A 5fsaB-4l15A:
undetectable
5fsaB-4l15A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE


(Aspergillus
fischeri)
PF11991
(Trp_DMAT)
3 PRO A 243
LEU A 281
SER A 346
None
0.72A 5fsaB-4ld7A:
undetectable
5fsaB-4ld7A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1


(Homo sapiens)
PF00400
(WD40)
3 PRO A 179
LEU A 231
SER A 235
None
0.77A 5fsaB-4lg9A:
undetectable
5fsaB-4lg9A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A


(Ustilago maydis)
PF03664
(Glyco_hydro_62)
3 PRO A  41
LEU A 283
SER A 267
None
0.81A 5fsaB-4n2rA:
undetectable
5fsaB-4n2rA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN


(Bacteroides
thetaiotaomicron)
PF16819
(DUF5074)
PF16820
(PKD_3)
3 PRO A 348
LEU A 398
SER A 442
None
0.71A 5fsaB-4r5oA:
undetectable
5fsaB-4r5oA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus)
PF14498
(Glyco_hyd_65N_2)
3 PRO A 188
LEU A  59
SER A 360
None
0.72A 5fsaB-4ufcA:
undetectable
5fsaB-4ufcA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6z ALCOHOL
DEHYDROGENASE 1


(Saccharomyces
cerevisiae)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 PRO A 271
LEU A 182
SER A 248
None
8ID  A 403 (-3.3A)
8ID  A 403 (-3.5A)
0.78A 5fsaB-4w6zA:
undetectable
5fsaB-4w6zA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A


(Pseudomonas
aeruginosa)
PF01425
(Amidase)
3 PRO A 180
LEU A 120
SER A 176
None
0.83A 5fsaB-4wj3A:
1.1
5fsaB-4wj3A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xk1 PHOSPHOSERINE
AMINOTRANSFERASE


(Pseudomonas
aeruginosa)
PF00266
(Aminotran_5)
3 PRO A 132
LEU A 139
SER A 122
None
0.74A 5fsaB-4xk1A:
undetectable
5fsaB-4xk1A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL


(Mus musculus)
PF01370
(Epimerase)
3 PRO A 223
LEU A 355
SER A 294
None
0.82A 5fsaB-4yraA:
undetectable
5fsaB-4yraA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyl RPHYB PROTEIN

(Rhodopseudomonas
palustris)
PF00072
(Response_reg)
3 PRO A   8
LEU A 136
SER A  33
None
0.78A 5fsaB-4zylA:
undetectable
5fsaB-4zylA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a20 MAJOR TAIL PROTEIN
GP17.1


(Bacillus phage
SPP1)
PF06199
(Phage_tail_2)
3 PRO H 147
LEU H  43
SER H  58
None
0.44A 5fsaB-5a20H:
undetectable
5fsaB-5a20H:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3f DYNAMIN 3

(Homo sapiens)
PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED)
3 PRO A  68
LEU A  29
SER A 117
None
0.77A 5fsaB-5a3fA:
0.1
5fsaB-5a3fA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqp EDTA MONOOXYGENASE

(EDTA-degrading
bacterium BNC1)
PF00296
(Bac_luciferase)
3 PRO A  59
LEU A  55
SER A  96
None
0.83A 5fsaB-5dqpA:
undetectable
5fsaB-5dqpA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN


(Bacteroides
thetaiotaomicron)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
3 PRO B 135
LEU B  64
SER B  58
None
0.84A 5fsaB-5fq6B:
undetectable
5fsaB-5fq6B:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN


(Alicyclobacillus
acidocaldarius)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2)
3 PRO A  42
LEU A  24
SER A  86
None
0.61A 5fsaB-5gj8A:
undetectable
5fsaB-5gj8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN


(Alicyclobacillus
acidocaldarius)
PF02771
(Acyl-CoA_dh_N)
3 PRO D  42
LEU D  24
SER D  86
None
0.54A 5fsaB-5gj8D:
undetectable
5fsaB-5gj8D:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii)
no annotation 3 PRO A 130
LEU A 692
SER A 688
None
0.80A 5fsaB-5h7jA:
undetectable
5fsaB-5h7jA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB


(Mus musculus)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
3 PRO A 693
LEU A 622
SER A 664
None
0.65A 5fsaB-5hjrA:
undetectable
5fsaB-5hjrA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA


(Homo sapiens)
no annotation 3 PRO B  45
LEU B 134
SER B  68
None
0.61A 5fsaB-5iz5B:
undetectable
5fsaB-5iz5B:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp3 XANTHOMONAS OUTER
PROTEIN D


(Xanthomonas
euvesicatoria)
PF02902
(Peptidase_C48)
3 PRO A 503
LEU A 412
SER A 469
None
0.76A 5fsaB-5jp3A:
undetectable
5fsaB-5jp3A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMC


(Escherichia
coli)
PF06804
(Lipoprotein_18)
3 PRO C  88
LEU C 178
SER C 105
None
0.57A 5fsaB-5ljoC:
undetectable
5fsaB-5ljoC:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
3 PRO A 552
LEU A 933
SER A 727
None
0.63A 5fsaB-5m59A:
undetectable
5fsaB-5m59A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN


(Tribolium
castaneum)
no annotation 3 PRO A 473
LEU A 338
SER A 407
None
0.75A 5fsaB-5oatA:
undetectable
5fsaB-5oatA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tih CYRPA ANTIBODY FAB
HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 PRO H  86
LEU H  11
SER H  17
None
0.72A 5fsaB-5tihH:
undetectable
5fsaB-5tihH:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u22 N2152

(Neocallimastix
frontalis)
PF01229
(Glyco_hydro_39)
3 PRO A  69
LEU A 300
SER A  65
None
0.84A 5fsaB-5u22A:
undetectable
5fsaB-5u22A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubj ALPHA-L-ARABINOFURAN
OSIDASE AXHA-2


(Aspergillus
nidulans)
PF03664
(Glyco_hydro_62)
3 PRO A  55
LEU A 300
SER A 284
None
0.77A 5fsaB-5ubjA:
undetectable
5fsaB-5ubjA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhk O-GLCNACASE
TIM-BARREL DOMAIN


(Homo sapiens)
PF07555
(NAGidase)
3 PRO A 209
LEU A 171
SER A 168
None
0.85A 5fsaB-5uhkA:
undetectable
5fsaB-5uhkA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN C
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42


(Saccharomyces
cerevisiae)
no annotation 3 PRO B 113
LEU D  64
SER D 266
None
0.69A 5fsaB-5uz5B:
undetectable
5fsaB-5uz5B:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5via PSEUDOPEROXIDASE

(Leishmania
major)
PF00141
(peroxidase)
3 PRO A  59
LEU A 332
SER A 336
None
0.76A 5fsaB-5viaA:
undetectable
5fsaB-5viaA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtf VP1

(Hepatovirus A)
PF12944
(HAV_VP)
3 PRO A 119
LEU A 264
SER A 271
None
0.62A 5fsaB-5wtfA:
undetectable
5fsaB-5wtfA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C


(Paenibacillus
sp. A11-2)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2)
3 PRO A  42
LEU A  24
SER A  86
None
0.62A 5fsaB-5xdeA:
undetectable
5fsaB-5xdeA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN


(Thermus
thermophilus)
no annotation 3 PRO A 330
LEU A 455
SER A 645
None
0.83A 5fsaB-5xpgA:
undetectable
5fsaB-5xpgA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT


(Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194)
3 PRO C 897
LEU C2563
SER C2789
None
0.83A 5fsaB-5y3rC:
undetectable
5fsaB-5y3rC:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yly NITRATE REDUCTASE

(Ulva prolifera)
no annotation 3 PRO A 721
LEU A 756
SER A 760
None
0.80A 5fsaB-5ylyA:
undetectable
5fsaB-5ylyA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 SODIUM-COUPLED
NEUTRAL AMINO ACID
TRANSPORTER 9


(Danio rerio)
no annotation 3 PRO C 415
LEU C 350
SER C 492
None
0.71A 5fsaB-6c08C:
undetectable
5fsaB-6c08C:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY


(Thermobifida
fusca)
no annotation 3 PRO A 307
LEU A 260
SER A 264
None
0.72A 5fsaB-6c66A:
undetectable
5fsaB-6c66A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1


(Homo sapiens)
no annotation 3 PRO A 795
LEU A 482
SER A 460
None
0.77A 5fsaB-6caaA:
undetectable
5fsaB-6caaA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv0 SPIKE GLYCOPROTEIN

(Avian
coronavirus)
no annotation 3 PRO A 770
LEU A 681
SER A 671
None
0.59A 5fsaB-6cv0A:
undetectable
5fsaB-6cv0A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cvq APRATAXIN

(Homo sapiens)
no annotation 3 PRO A 206
LEU A 213
SER A 209
None
0.83A 5fsaB-6cvqA:
undetectable
5fsaB-6cvqA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cvq APRATAXIN

(Homo sapiens)
no annotation 3 PRO A 254
LEU A 203
SER A 212
AMP  A 401 (-4.5A)
AMP  A 401 ( 4.7A)
None
0.84A 5fsaB-6cvqA:
undetectable
5fsaB-6cvqA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC


(Spinacia
oleracea)
no annotation 3 PRO C 159
LEU C 383
SER C 369
None
0.84A 5fsaB-6fkhC:
undetectable
5fsaB-6fkhC:
10.99