SIMILAR PATTERNS OF AMINO ACIDS FOR 5FSA_A_X2NA590_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)

(Salmonella
enterica) 		PF00180
(Iso_dh) 		3 PRO A  56
ILE A  15
SER A  88
 None
 0.81A 5fsaA-1cnzA:
0.0		 5fsaA-1cnzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		3 PRO A 120
ILE A 688
SER A 127
 None
 0.61A 5fsaA-1e1cA:
0.0		 5fsaA-1e1cA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		3 PRO A 233
ILE A 106
SER A 178
 None
 0.68A 5fsaA-1fizA:
0.0		 5fsaA-1fizA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 PRO A 212
ILE A  33
SER A 340
 None
 0.70A 5fsaA-1g0dA:
0.0		 5fsaA-1g0dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h14 ENDO-1,4-BETA-XYLANA
SE

(Pseudoalteromonas
haloplanktis) 		PF01270
(Glyco_hydro_8) 		3 PRO A 143
ILE A 173
SER A 192
 None
 0.68A 5fsaA-1h14A:
0.0		 5fsaA-1h14A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882

(Lophonetta
specularioides) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		3 PRO A  57
ILE A  70
SER A  32
 None
 0.79A 5fsaA-1h8lA:
0.0		 5fsaA-1h8lA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		3 PRO A 471
ILE A 126
SER A 464
 None
 0.71A 5fsaA-1iq0A:
0.0		 5fsaA-1iq0A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqq S3-RNASE

(Pyrus pyrifolia) 		PF00445
(Ribonuclease_T2) 		3 PRO A  37
ILE A 167
SER A  90
 None
 0.76A 5fsaA-1iqqA:
0.0		 5fsaA-1iqqA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzt HYPOTHETICAL 27.5
KDA PROTEIN IN
SPX19-GCR2
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF03853
(YjeF_N) 		3 PRO A 175
ILE A 166
SER A 205
 None
 0.79A 5fsaA-1jztA:
0.0		 5fsaA-1jztA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0q SURFACE LAYER
PROTEIN

(Methanosarcina
mazei) 		PF00801
(PKD)
PF10282
(Lactonase) 		3 PRO A  41
ILE A  17
SER A  82
 None
 0.66A 5fsaA-1l0qA:
undetectable		 5fsaA-1l0qA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lml LEISHMANOLYSIN

(Leishmania
major) 		PF01457
(Peptidase_M8) 		3 PRO A 460
ILE A 335
SER A 462
 None
 0.73A 5fsaA-1lmlA:
undetectable		 5fsaA-1lmlA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnt OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		3 PRO A  76
ILE A 305
SER A 316
 None
 0.79A 5fsaA-1nntA:
undetectable		 5fsaA-1nntA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 PRO A  69
ILE A  94
SER A 113
 None
 0.79A 5fsaA-1nr0A:
undetectable		 5fsaA-1nr0A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw5 MODIFICATION
METHYLASE RSRI

(Rhodobacter
sphaeroides) 		PF01555
(N6_N4_Mtase) 		3 PRO A 228
ILE A 102
SER A 211
 None
 0.81A 5fsaA-1nw5A:
undetectable		 5fsaA-1nw5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 PRO A 106
ILE A  99
SER A 202
 None
 0.00A 5fsaA-1q5aA:
undetectable		 5fsaA-1q5aA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5f PYRUVATE OXIDASE

(Aerococcus
viridans) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 PRO A 544
ILE A 348
SER A 392
 None
None
TPP  A1602 (-2.7A)
 0.78A 5fsaA-1v5fA:
undetectable		 5fsaA-1v5fA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v77 HYPOTHETICAL PROTEIN
PH1877

(Pyrococcus
horikoshii) 		PF01876
(RNase_P_p30) 		3 PRO A 203
ILE A  34
SER A 198
 None
 0.64A 5fsaA-1v77A:
undetectable		 5fsaA-1v77A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		3 PRO A  82
ILE A  97
SER A 123
 None
 0.79A 5fsaA-1vf8A:
undetectable		 5fsaA-1vf8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpk DNA POLYMERASE III,
BETA SUBUNIT

(Thermotoga
maritima) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		3 PRO A 248
ILE A 353
SER A 344
 None
 0.65A 5fsaA-1vpkA:
undetectable		 5fsaA-1vpkA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA)
PF07737
(ATLF) 		3 PRO A 365
ILE A 462
SER A 354
 None
 0.76A 5fsaA-1xfuA:
1.3		 5fsaA-1xfuA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE

(Chlorobaculum
tepidum) 		PF04371
(PAD_porph) 		3 PRO A 299
ILE A  55
SER A 285
 None
 0.75A 5fsaA-1xknA:
undetectable		 5fsaA-1xknA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zan FAB AD11 LIGHT CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO L  40
ILE L  48
SER L 169
 None
 0.79A 5fsaA-1zanL:
undetectable		 5fsaA-1zanL:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aey FRUCTAN
1-EXOHYDROLASE IIA

(Cichorium
intybus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 PRO A 406
ILE A 476
SER A 400
 None
 0.78A 5fsaA-2aeyA:
undetectable		 5fsaA-2aeyA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be9 ASPARTATE
CARBAMOYLTRANSFERASE
REGULATORY CHAIN

(Sulfolobus
acidocaldarius) 		PF01948
(PyrI)
PF02748
(PyrI_C) 		3 PRO B 128
ILE B  78
SER B 121
 None
 0.70A 5fsaA-2be9B:
undetectable		 5fsaA-2be9B:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1

(Saccharomyces
cerevisiae) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 PRO A 353
ILE A 422
SER A 257
 None
 0.75A 5fsaA-2cvtA:
undetectable		 5fsaA-2cvtA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		3 PRO A  76
ILE A 305
SER A 316
 None
 0.80A 5fsaA-2d3iA:
undetectable		 5fsaA-2d3iA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg9 ADP-RIBOSYL CYCLASE
1

(Mus musculus) 		PF02267
(Rib_hydrolayse) 		3 PRO A 219
ILE A 250
SER A 261
 None
 0.80A 5fsaA-2eg9A:
undetectable		 5fsaA-2eg9A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Staphylococcus
aureus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		3 PRO B 147
ILE B 173
SER B  19
 None
 0.81A 5fsaA-2f2aB:
undetectable		 5fsaA-2f2aB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcg ANTIBACTERIAL
PROTEIN FALL-39,
CORE PEPTIDE

(Homo sapiens) 		PF12153
(CAP18_C) 		3 PRO F  33
ILE F  20
SER F  37
 None
 0.74A 5fsaA-2fcgF:
undetectable		 5fsaA-2fcgF:
4.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiy PROTEIN FDHE HOMOLOG

(Pseudomonas
aeruginosa) 		PF04216
(FdhE) 		3 PRO A 192
ILE A 138
SER A 226
 None
 0.78A 5fsaA-2fiyA:
undetectable		 5fsaA-2fiyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		3 PRO A 261
ILE A 151
SER A 328
 None
 0.77A 5fsaA-2fncA:
undetectable		 5fsaA-2fncA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h39 PROBABLE
GALACTOSE-1-PHOSPHAT
E URIDYL TRANSFERASE

(Arabidopsis
thaliana) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		3 PRO A  39
ILE A 248
SER A  22
 None
 0.77A 5fsaA-2h39A:
undetectable		 5fsaA-2h39A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE

(Homo sapiens) 		PF00171
(Aldedh) 		3 PRO A 751
ILE A 495
SER A 728
 None
 0.79A 5fsaA-2h5gA:
undetectable		 5fsaA-2h5gA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES

(Bacillus cereus) 		PF03486
(HI0933_like) 		3 PRO A 193
ILE A 231
SER A 354
 None
 0.80A 5fsaA-2i0zA:
undetectable		 5fsaA-2i0zA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 HYPOTHETICAL PROTEIN
YPL007C

(Saccharomyces
cerevisiae) 		PF12660
(zf-TFIIIC) 		3 PRO A 216
ILE A 158
SER A 218
 None
 0.81A 5fsaA-2j04A:
undetectable		 5fsaA-2j04A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 HYPOTHETICAL PROTEIN
YPL007C
YDR362CP

(Saccharomyces
cerevisiae) 		PF12660
(zf-TFIIIC)
no annotation 		3 PRO A 244
ILE A 234
SER B 457
 None
 0.77A 5fsaA-2j04A:
undetectable		 5fsaA-2j04A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		3 PRO A 417
ILE A  19
SER A 430
 None
 0.60A 5fsaA-2pi5A:
2.1		 5fsaA-2pi5A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 PRO A 969
ILE A 977
SER A 513
 None
 0.74A 5fsaA-2vdcA:
undetectable		 5fsaA-2vdcA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vtc CEL61B

(Trichoderma
reesei) 		PF03443
(Glyco_hydro_61) 		3 PRO A 152
ILE A  68
SER A 187
 None
 0.80A 5fsaA-2vtcA:
undetectable		 5fsaA-2vtcA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF13638
(PIN_4)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		3 PRO J 759
ILE J 807
SER J 296
 None
 0.65A 5fsaA-2wp8J:
undetectable		 5fsaA-2wp8J:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 PRO A 425
ILE A 414
SER A 614
 None
 0.78A 5fsaA-2xaxA:
undetectable		 5fsaA-2xaxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvn ASPERGILLUS
FUMIGATUS CHITINASE
A1

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		3 PRO A  65
ILE A  58
SER A 136
 None
 0.73A 5fsaA-2xvnA:
undetectable		 5fsaA-2xvnA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z87 CHONDROITIN SYNTHASE

(Escherichia
coli) 		PF00535
(Glycos_transf_2) 		3 PRO A 246
ILE A 265
SER A 286
 None
 0.73A 5fsaA-2z87A:
undetectable		 5fsaA-2z87A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 3 PRO A 445
ILE A 749
SER A 520
 None
 0.81A 5fsaA-3a0fA:
undetectable		 5fsaA-3a0fA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b98 PROSTAGLANDIN I2
SYNTHASE

(Danio rerio) 		PF00067
(p450) 		3 PRO A 205
ILE A 193
SER A 459
 None
 0.80A 5fsaA-3b98A:
30.3		 5fsaA-3b98A:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		3 PRO A 504
ILE A 534
SER A 474
 None
 0.81A 5fsaA-3ciyA:
undetectable		 5fsaA-3ciyA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clm TRANSALDOLASE

(Neisseria
gonorrhoeae) 		PF00923
(TAL_FSA) 		3 PRO A  44
ILE A 202
SER A 109
 None
 0.73A 5fsaA-3clmA:
undetectable		 5fsaA-3clmA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmg PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 PRO A 265
ILE A 281
SER A 205
 None
 0.73A 5fsaA-3cmgA:
undetectable		 5fsaA-3cmgA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvr INVASION PLASMID
ANTIGEN

(Shigella
flexneri) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		3 PRO A 179
ILE A 236
SER A 161
 None
 0.72A 5fsaA-3cvrA:
0.3		 5fsaA-3cvrA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM

(Homo sapiens) 		no annotation 3 PRO B 236
ILE B  99
SER B 296
 None
 0.79A 5fsaA-3dw8B:
undetectable		 5fsaA-3dw8B:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb8 CYSTEINE
PROTEASE-LIKE VIRA

(Shigella
flexneri) 		PF06872
(EspG) 		3 PRO A 125
ILE A 321
SER A  64
 None
 0.63A 5fsaA-3eb8A:
undetectable		 5fsaA-3eb8A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee1 EFFECTOR PROTEIN
VIRA

(Shigella
flexneri) 		PF06872
(EspG) 		3 PRO A 125
ILE A 321
SER A  64
 None
 0.79A 5fsaA-3ee1A:
undetectable		 5fsaA-3ee1A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ele AMINO TRANSFERASE

([Eubacterium]
rectale) 		PF00155
(Aminotran_1_2) 		3 PRO A  44
ILE A 358
SER A 246
 None
None
PLP  A 500 (-2.7A)
 0.74A 5fsaA-3eleA:
undetectable		 5fsaA-3eleA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE

(Mus musculus) 		PF00288
(GHMP_kinases_N) 		3 PRO A 379
ILE A  56
SER A 162
 None
 0.81A 5fsaA-3f0nA:
0.6		 5fsaA-3f0nA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo8 TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF17481
(Phage_sheath_1N) 		3 PRO D 253
ILE D 171
SER D 335
 None
 0.78A 5fsaA-3fo8D:
undetectable		 5fsaA-3fo8D:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0t PUTATIVE
AMINOTRANSFERASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		3 PRO A  78
ILE A  66
SER A 308
 None
 0.74A 5fsaA-3g0tA:
undetectable		 5fsaA-3g0tA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		3 PRO A  58
ILE A  84
SER A 100
 None
NIL  A   1 (-4.4A)
None
 0.67A 5fsaA-3gp0A:
undetectable		 5fsaA-3gp0A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqc DNA REPAIR PROTEIN
REV1

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		3 PRO A 463
ILE A 720
SER A 501
 None
 0.79A 5fsaA-3gqcA:
undetectable		 5fsaA-3gqcA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4y PUTATIVE CHEMOTAXIS
PROTEIN

(Desulfovibrio
vulgaris) 		PF13690
(CheX) 		3 PRO A  33
ILE A  49
SER A   2
 None
 0.70A 5fsaA-3h4yA:
undetectable		 5fsaA-3h4yA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF02738
(Ald_Xan_dh_C2) 		3 PRO B 297
ILE B 259
SER B  10
 None
 0.60A 5fsaA-3hrdB:
undetectable		 5fsaA-3hrdB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k55 BETA-HEMOLYSIN

(Staphylococcus
aureus) 		PF03372
(Exo_endo_phos) 		3 PRO A  76
ILE A 191
SER A  83
 None
 0.71A 5fsaA-3k55A:
undetectable		 5fsaA-3k55A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2o F-BOX ONLY PROTEIN 4

(Homo sapiens) 		PF00646
(F-box) 		3 PRO B 205
ILE B 214
SER B 199
 None
 0.77A 5fsaA-3l2oB:
undetectable		 5fsaA-3l2oB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2o F-BOX ONLY PROTEIN 4

(Homo sapiens) 		PF00646
(F-box) 		3 PRO B 205
ILE B 217
SER B 200
 None
 0.73A 5fsaA-3l2oB:
undetectable		 5fsaA-3l2oB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		3 PRO A 725
ILE A 784
SER A 694
 None
PEG  A7001 (-4.5A)
None
 0.74A 5fsaA-3lppA:
undetectable		 5fsaA-3lppA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3miz PUTATIVE
TRANSCRIPTIONAL
REGULATOR PROTEIN,
LACI FAMILY

(Rhizobium etli) 		PF13377
(Peripla_BP_3) 		3 PRO A 298
ILE A  93
SER A 327
 None
 0.78A 5fsaA-3mizA:
undetectable		 5fsaA-3mizA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 PRO B  59
ILE A  99
SER A  16
 None
 0.77A 5fsaA-3mm5B:
undetectable		 5fsaA-3mm5B:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o81 BETA-2-MICROGLOBULIN

(Gallus gallus) 		PF07654
(C1-set) 		3 PRO A  72
ILE A  37
SER A  16
 None
 0.73A 5fsaA-3o81A:
undetectable		 5fsaA-3o81A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5n RIBOFLAVIN UPTAKE
PROTEIN

(Staphylococcus
aureus) 		PF12822
(ECF_trnsprt) 		3 PRO A  50
ILE A  35
SER A  22
 None
 0.78A 5fsaA-3p5nA:
1.4		 5fsaA-3p5nA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5n RIBOFLAVIN UPTAKE
PROTEIN

(Staphylococcus
aureus) 		PF12822
(ECF_trnsprt) 		3 PRO A  50
ILE A 166
SER A  22
 None
 0.61A 5fsaA-3p5nA:
1.4		 5fsaA-3p5nA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE

(Francisella
tularensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 PRO A 281
ILE A 347
SER A 187
 None
 0.58A 5fsaA-3qtyA:
undetectable		 5fsaA-3qtyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r31 BETAINE ALDEHYDE
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF00171
(Aldedh) 		3 PRO A  13
ILE A 106
SER A  16
 None
 0.75A 5fsaA-3r31A:
undetectable		 5fsaA-3r31A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsc PUTATIVE
OXIDOREDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		3 PRO A 165
ILE A 155
SER A 227
 None
NAD  A 274 (-4.6A)
None
 0.79A 5fsaA-3tscA:
undetectable		 5fsaA-3tscA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3x OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 PRO A 153
ILE A  39
SER A 313
 None
 0.68A 5fsaA-3u3xA:
undetectable		 5fsaA-3u3xA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4y UNCHARACTERIZED
PROTEIN

(Desulfotomaculum
acetoxidans) 		PF10282
(Lactonase) 		3 PRO A 182
ILE A 142
SER A 226
 None
 0.74A 5fsaA-3u4yA:
undetectable		 5fsaA-3u4yA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uss PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF05995
(CDO_I) 		3 PRO A 117
ILE A 138
SER A 172
 None
 0.30A 5fsaA-3ussA:
undetectable		 5fsaA-3ussA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnk XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

([Clostridium]
cellulolyticum) 		PF01261
(AP_endonuc_2) 		3 PRO A  68
ILE A  32
SER A 110
 None
 0.75A 5fsaA-3vnkA:
undetectable		 5fsaA-3vnkA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo) 		PF00082
(Peptidase_S8) 		3 PRO A 490
ILE A 550
SER A 477
 None
 0.80A 5fsaA-3vtaA:
undetectable		 5fsaA-3vtaA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A

(Schizosaccharomyces
pombe) 		PF08662
(eIF2A) 		3 PRO A 319
ILE A 285
SER A 362
 None
 0.56A 5fsaA-3wj9A:
undetectable		 5fsaA-3wj9A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CMR4
CRISPR SYSTEM CMR
SUBUNIT CMR5

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs)
PF09701
(Cas_Cmr5) 		3 PRO C 134
ILE F   6
SER C 287
 None
 0.73A 5fsaA-3x1lC:
undetectable		 5fsaA-3x1lC:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		3 PRO A 603
ILE A 609
SER A 481
 None
 0.73A 5fsaA-3zzuA:
undetectable		 5fsaA-3zzuA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0t PUP--PROTEIN LIGASE

(Corynebacterium
glutamicum) 		PF03136
(Pup_ligase) 		3 PRO A 210
ILE A 203
SER A 214
 None
 0.76A 5fsaA-4b0tA:
undetectable		 5fsaA-4b0tA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boo ACETYLCHOLINE
RECEPTOR BETA
SUBUNIT

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		3 PRO B 464
ILE B 130
SER B 459
 None
 0.80A 5fsaA-4booB:
2.3		 5fsaA-4booB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cbx ACTIN-2

(Plasmodium
berghei) 		PF00022
(Actin) 		3 PRO A 102
ILE A 136
SER A   5
 None
 0.81A 5fsaA-4cbxA:
undetectable		 5fsaA-4cbxA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccw CARBOXYL ESTERASE NP

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		3 PRO A 214
ILE A 247
SER A 102
 None
 0.63A 5fsaA-4ccwA:
undetectable		 5fsaA-4ccwA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cit VANADIUM-DEPENDENT
HALOPEROXIDASE

(Zobellia
galactanivorans) 		PF01569
(PAP2) 		3 PRO A 262
ILE A 254
SER A  50
 OCS  A 260 ( 4.9A)
None
None
 0.80A 5fsaA-4citA:
undetectable		 5fsaA-4citA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0c BETA-2-MICROGLOBULIN

(Gallus gallus) 		PF07654
(C1-set) 		3 PRO B  71
ILE B  36
SER B  15
 None
 0.65A 5fsaA-4d0cB:
undetectable		 5fsaA-4d0cB:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0k A-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Chaetomium
thermophilum) 		no annotation 3 PRO A 248
ILE A 160
SER A 293
 None
 0.73A 5fsaA-4d0kA:
undetectable		 5fsaA-4d0kA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		no annotation 3 PRO A 422
ILE A 786
SER A 651
 None
 0.71A 5fsaA-4ecoA:
undetectable		 5fsaA-4ecoA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG

(Sphingomonas
paucimobilis) 		PF13417
(GST_N_3)
PF16865
(GST_C_5) 		3 PRO A 227
ILE A 121
SER A 233
 None
 0.77A 5fsaA-4g10A:
undetectable		 5fsaA-4g10A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP2
CAPSID PROTEIN VP3

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 PRO C 134
ILE C 105
SER B 216
 None
 0.81A 5fsaA-4gh4C:
undetectable		 5fsaA-4gh4C:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		3 PRO M 107
ILE M 127
SER M  33
 None
 0.79A 5fsaA-4gq2M:
0.9		 5fsaA-4gq2M:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Acinetobacter
sp. ADP1) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		3 PRO A 272
ILE A 343
SER A 253
 None
 0.61A 5fsaA-4gtnA:
undetectable		 5fsaA-4gtnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0n DNMT2

(Spodoptera
frugiperda) 		PF00145
(DNA_methylase) 		3 PRO A 302
ILE A 197
SER A  40
 None
 0.81A 5fsaA-4h0nA:
undetectable		 5fsaA-4h0nA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn3 LMO1757 PROTEIN

(Listeria
monocytogenes) 		PF07537
(CamS) 		3 PRO A  93
ILE A 220
SER A  48
 None
 0.70A 5fsaA-4hn3A:
undetectable		 5fsaA-4hn3A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME

(Rickettsia
typhi) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 PRO A 110
ILE A 116
SER A 106
 None
 0.41A 5fsaA-4hvtA:
undetectable		 5fsaA-4hvtA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		3 PRO A 136
ILE A  82
SER A 328
 None
 0.79A 5fsaA-4issA:
undetectable		 5fsaA-4issA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2

(Homo sapiens) 		PF00400
(WD40) 		3 PRO A 156
ILE A 462
SER A 208
 None
 0.79A 5fsaA-4j0wA:
undetectable		 5fsaA-4j0wA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0x RIBOSOMAL
RNA-PROCESSING
PROTEIN 9

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 PRO A 246
ILE A 524
SER A 292
 None
 0.78A 5fsaA-4j0xA:
undetectable		 5fsaA-4j0xA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le5 S-ADENOSYLMETHIONINE
SYNTHETASE

(Campylobacter
jejuni) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 PRO A 319
ILE A 269
SER A 347
 None
 0.66A 5fsaA-4le5A:
undetectable		 5fsaA-4le5A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II

(Acidothermus
cellulolyticus) 		no annotation 3 PRO A 423
ILE A 327
SER A 359
 None
 0.70A 5fsaA-4lgnA:
undetectable		 5fsaA-4lgnA:
20.39