SIMILAR PATTERNS OF AMINO ACIDS FOR 5FSA_A_X2NA590_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0c XYLOSE ISOMERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF01261
(AP_endonuc_2) 		5 LEU A 335
PHE A 330
PHE A 362
GLY A 292
LEU A 282
 None
 1.11A 5fsaA-1a0cA:
0.0		 5fsaA-1a0cA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0e XYLOSE ISOMERASE

(Thermotoga
neapolitana) 		PF01261
(AP_endonuc_2) 		5 LEU A 335
PHE A 330
PHE A 362
GLY A 292
LEU A 282
 None
 1.07A 5fsaA-1a0eA:
0.0		 5fsaA-1a0eA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhd UTROPHIN

(Homo sapiens) 		PF00307
(CH) 		5 TYR A 246
LEU A 247
GLY A 182
LEU A 189
HIS A 192
 None
 1.06A 5fsaA-1bhdA:
undetectable		 5fsaA-1bhdA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)

(Pedobacter
heparinus) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 ALA A 355
TYR A 356
LEU A 617
ILE A 650
HIS A 351
 None
 1.09A 5fsaA-1cb8A:
0.0		 5fsaA-1cb8A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpb DIHYDROLIPOYL-TRANSA
CETYLASE

(Azotobacter
vinelandii) 		PF00198
(2-oxoacid_dh) 		5 LEU A 477
PHE A 555
ILE A 503
PHE A 621
LEU A 629
 None
 1.08A 5fsaA-1dpbA:
undetectable		 5fsaA-1dpbA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gux RETINOBLASTOMA
PROTEIN

(Homo sapiens) 		PF01858
(RB_A) 		5 ALA A 562
LEU A 550
ILE A 382
PHE A 535
PHE A 514
 None
 1.02A 5fsaA-1guxA:
undetectable		 5fsaA-1guxA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkg HEXOKINASE A

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 LEU A 133
ILE A 187
PHE A 175
GLY A 434
LEU A  74
 None
 1.17A 5fsaA-1hkgA:
1.2		 5fsaA-1hkgA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 ALA A 111
LEU A 137
ILE A  55
GLY A 134
LEU A  66
 None
 1.04A 5fsaA-1hkkA:
undetectable		 5fsaA-1hkkA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		5 TYR B   4
LEU B  80
PHE B  71
GLY B 102
HIS B  53
 None
 1.20A 5fsaA-1htrB:
0.0		 5fsaA-1htrB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 ALA A 343
LEU A 282
PHE A 306
GLY A 600
LEU A 407
 None
 0.98A 5fsaA-1ksiA:
0.0		 5fsaA-1ksiA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 ALA A1509
ILE A1790
PHE A1876
GLY A1874
LEU A1594
 None
 1.18A 5fsaA-1larA:
0.0		 5fsaA-1larA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lln ANTIVIRAL PROTEIN 3

(Phytolacca
americana) 		PF00161
(RIP) 		5 ALA A 149
LEU A  61
ILE A   2
LEU A 137
PHE A  59
 None
None
None
MLY  A 134 ( 4.8A)
None
 1.21A 5fsaA-1llnA:
undetectable		 5fsaA-1llnA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrf REGULATORY PROTEIN
BLAR1

(Bacillus
licheniformis) 		PF00905
(Transpeptidase) 		5 TYR A 596
LEU A 587
PHE A 567
PHE A 554
GLY A 538
 None
 1.05A 5fsaA-1nrfA:
undetectable		 5fsaA-1nrfA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohe CDC14B2 PHOSPHATASE

(Homo sapiens) 		PF00782
(DSPc)
PF14671
(DSPn) 		5 TYR A 268
ILE A 220
PHE A 299
HIS A 280
PHE A 227
 None
 1.17A 5fsaA-1oheA:
undetectable		 5fsaA-1oheA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 ALA A 415
PHE A 268
ILE A 249
PHE A 527
HIS A 579
 FAD  A 701 (-3.6A)
None
None
None
None
 1.07A 5fsaA-1ps9A:
undetectable		 5fsaA-1ps9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 ALA A 111
LEU A 137
ILE A  55
GLY A 134
LEU A  66
 None
 1.03A 5fsaA-1wb0A:
undetectable		 5fsaA-1wb0A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		5 ALA A 231
LEU A  96
ILE A 127
GLY A  81
PHE A  37
 None
 1.06A 5fsaA-1x1nA:
undetectable		 5fsaA-1x1nA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		5 ALA A 121
LEU A 240
PHE A 205
ILE A 216
LEU A 148
 None
 0.92A 5fsaA-1ycnA:
undetectable		 5fsaA-1ycnA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE

(Clostridium
acetobutylicum) 		PF04616
(Glyco_hydro_43) 		5 ALA A 392
TYR A 532
ILE A  73
PHE A 510
LEU A  51
 None
 1.21A 5fsaA-1yi7A:
undetectable		 5fsaA-1yi7A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yka MONOTHIOL
GLUTAREDOXIN YDHD

(Escherichia
coli) 		PF00462
(Glutaredoxin) 		5 TYR A  49
LEU A  19
ILE A  52
PHE A  47
GLY A  31
 None
 1.05A 5fsaA-1ykaA:
undetectable		 5fsaA-1ykaA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 ALA A 794
ILE A 686
GLY A 710
HIS A 804
PHE A 724
 None
 1.17A 5fsaA-2b3xA:
undetectable		 5fsaA-2b3xA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw7 ENDONUCLEASE
PI-PKOII

(Thermococcus
kodakarensis) 		PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		5 ALA A 445
TYR A 446
PHE A 436
GLY A 378
LEU A 394
 None
 1.22A 5fsaA-2cw7A:
undetectable		 5fsaA-2cw7A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		5 ALA A 263
TYR A 270
LEU A 167
PHE A 309
GLY A 251
 None
NAD  A5555 (-3.6A)
None
None
None
 1.21A 5fsaA-2fknA:
0.7		 5fsaA-2fknA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o62 HYPOTHETICAL PROTEIN

(Nostoc
punctiforme) 		PF12204
(DUF3598) 		5 LEU A 116
ILE A 198
PHE A 110
GLY A  26
LEU A 106
 GOL  A 277 (-4.4A)
None
None
None
None
 1.07A 5fsaA-2o62A:
undetectable		 5fsaA-2o62A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pof CDP-DIACYLGLYCEROL
PYROPHOSPHATASE

(Escherichia
coli) 		PF02611
(CDH) 		5 ALA A 237
PHE A 193
GLY A  63
LEU A  78
PHE A 101
 None
 1.04A 5fsaA-2pofA:
undetectable		 5fsaA-2pofA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qga ADENYLOSUCCINATE
LYASE

(Plasmodium
vivax) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 ALA B 202
TYR B 239
LEU B 117
PHE B  50
PHE B 211
 None
 1.14A 5fsaA-2qgaB:
1.6		 5fsaA-2qgaB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhg TYROCIDINE
SYNTHETASE A

(Brevibacillus
brevis) 		PF00668
(Condensation) 		5 ALA A 278
LEU A 264
ILE A 259
PHE A 367
GLY A 415
 None
 1.19A 5fsaA-2xhgA:
undetectable		 5fsaA-2xhgA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb4 AMIDOHYDROLASE

(Chromobacterium
violaceum) 		PF02811
(PHP) 		5 ALA A  16
ILE A 280
PHE A   8
GLY A  80
LEU A  45
 None
 1.21A 5fsaA-2yb4A:
undetectable		 5fsaA-2yb4A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be8 NEUROLIGIN-4,
X-LINKED

(Homo sapiens) 		PF00135
(COesterase) 		5 LEU A 132
ILE A 185
PHE A 128
GLY A 174
LEU A 205
 None
None
None
PO4  A 623 ( 3.6A)
None
 1.01A 5fsaA-3be8A:
undetectable		 5fsaA-3be8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bin BAND 4.1-LIKE
PROTEIN 3

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 ALA A 280
LEU A 145
PHE A 136
GLY A 152
LEU A 117
 None
 1.17A 5fsaA-3binA:
undetectable		 5fsaA-3binA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		5 TYR A 204
LEU A 206
ILE A 196
GLY A 121
HIS A 188
 None
 1.09A 5fsaA-3c0kA:
undetectable		 5fsaA-3c0kA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2u XYLOSIDASE/ARABINOSI
DASE

(Selenomonas
ruminantium) 		PF04616
(Glyco_hydro_43)
PF07081
(DUF1349) 		5 ALA A 394
TYR A 534
ILE A  72
PHE A 512
LEU A  50
 None
 1.21A 5fsaA-3c2uA:
undetectable		 5fsaA-3c2uA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6t ASPARTATE
AMINOTRANSFERASE

(Lactobacillus
acidophilus) 		PF00155
(Aminotran_1_2) 		5 ALA A 264
LEU A 306
ILE A 146
GLY A 322
PHE A 293
 None
 1.17A 5fsaA-3f6tA:
undetectable		 5fsaA-3f6tA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnc PUTATIVE
ACETYLTRANSFERASE

(Listeria
innocua) 		PF13673
(Acetyltransf_10) 		5 ALA A  56
LEU A  84
PHE A 130
PHE A  87
GLY A  99
 None
None
MLI  A 162 (-4.7A)
None
MLI  A 162 (-3.4A)
 1.19A 5fsaA-3fncA:
undetectable		 5fsaA-3fncA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gka N-ETHYLMALEIMIDE
REDUCTASE

(Burkholderia
pseudomallei) 		PF00724
(Oxidored_FMN) 		5 ALA A 167
LEU A 215
ILE A 207
GLY A 253
LEU A 234
 None
 1.04A 5fsaA-3gkaA:
undetectable		 5fsaA-3gkaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		5 ALA A 345
TYR A 539
PHE A 253
PHE A 278
LEU A 432
 None
 1.18A 5fsaA-3hjrA:
undetectable		 5fsaA-3hjrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN

(Streptomyces
coelicolor) 		PF01547
(SBP_bac_1) 		5 PHE A 154
ILE A 320
PHE A 351
GLY A  54
LEU A  59
 None
 1.15A 5fsaA-3i3vA:
undetectable		 5fsaA-3i3vA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3imh GALACTOSE-1-EPIMERAS
E

(Lactobacillus
acidophilus) 		PF01263
(Aldose_epim) 		5 ALA A 211
LEU A 273
PHE A 244
GLY A 293
LEU A 227
 None
 1.08A 5fsaA-3imhA:
undetectable		 5fsaA-3imhA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES1

(Plasmodium
falciparum) 		PF01015
(Ribosomal_S3Ae) 		5 ALA B  71
LEU B  32
ILE B  91
PHE B  43
GLY B  63
 None
 1.13A 5fsaA-3j7aB:
undetectable		 5fsaA-3j7aB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kya PUTATIVE PHOSPHATASE

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		5 ALA A 223
TYR A 177
ILE A 189
PHE A 215
PHE A 256
 None
 1.12A 5fsaA-3kyaA:
undetectable		 5fsaA-3kyaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng0 GLUTAMINE SYNTHETASE

(Synechocystis
sp. PCC 6803) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		5 ALA A 133
ILE A 123
PHE A 129
GLY A 385
LEU A 360
 None
 1.16A 5fsaA-3ng0A:
undetectable		 5fsaA-3ng0A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o9p PERIPLASMIC MUREIN
PEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		5 PHE A 424
PHE A 109
GLY A 269
LEU A  34
PHE A 162
 None
None
None
MHI  A 516 (-3.7A)
None
 1.13A 5fsaA-3o9pA:
undetectable		 5fsaA-3o9pA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otn SUSD SUPERFAMILY
PROTEIN

(Parabacteroides
distasonis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 ALA A 213
TYR A 382
TYR A 184
GLY A 233
PHE A 151
 None
 1.03A 5fsaA-3otnA:
undetectable		 5fsaA-3otnA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pic CIP2

(Trichoderma
reesei) 		no annotation 5 PHE A 213
ILE A 195
PHE A 177
GLY A 251
LEU A 155
 None
 1.19A 5fsaA-3picA:
undetectable		 5fsaA-3picA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q63 MLL2253 PROTEIN

(Mesorhizobium
japonicum) 		PF08327
(AHSA1) 		5 ALA A  67
LEU A  38
PHE A 131
LEU A  61
PHE A  51
 None
 1.20A 5fsaA-3q63A:
undetectable		 5fsaA-3q63A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qre ENOYL-COA HYDRATASE,
ECHA12_1

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 ALA A  50
LEU A  59
ILE A 116
PHE A  24
GLY A 124
 None
 1.18A 5fsaA-3qreA:
undetectable		 5fsaA-3qreA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 ALA K  69
LEU K  19
ILE J 102
GLY L 601
LEU N 209
 None
 1.22A 5fsaA-3rkoK:
2.3		 5fsaA-3rkoK:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		5 ALA X 389
LEU X 272
ILE X 265
PHE X 295
LEU X  81
 None
 0.96A 5fsaA-3ss7X:
undetectable		 5fsaA-3ss7X:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v44 TOLL-LIKE RECEPTOR
5B AND VARIABLE
LYMPHOCYTE RECEPTOR
B.61 CHIMERIC
PROTEIN

(Danio rerio;
Eptatretus
burgeri) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU A 145
PHE A 166
GLY A 139
LEU A 111
PHE A  92
 None
 1.20A 5fsaA-3v44A:
undetectable		 5fsaA-3v44A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsk PENICILLIN-BINDING
PROTEIN 3

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 ALA A  46
LEU A  73
ILE A 320
GLY A 552
LEU A 284
 None
 1.13A 5fsaA-3vskA:
undetectable		 5fsaA-3vskA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7g CATALASE

(Corynebacterium
glutamicum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 ALA A  93
LEU A 129
PHE A 108
PHE A 127
PHE A 131
 None
 1.21A 5fsaA-4b7gA:
undetectable		 5fsaA-4b7gA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnh UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF06187
(DUF993) 		5 ALA A 350
LEU A 334
PHE A 330
LEU A 383
HIS A 386
 None
 1.13A 5fsaA-4dnhA:
undetectable		 5fsaA-4dnhA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		5 ALA A 551
LEU A 628
PHE A 666
PHE A 654
LEU A 616
 None
 1.19A 5fsaA-4ecnA:
undetectable		 5fsaA-4ecnA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1l ANI2.3 TCR A CHAIN
ANI2.3 TCR B CHAIN

(Escherichia
coli) 		PF07686
(V-set) 		5 ALA H  90
TYR H  31
TYR G  31
PHE G  33
GLY G  27
 None
 1.20A 5fsaA-4h1lH:
undetectable		 5fsaA-4h1lH:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hse CHAPERONE PROTEIN
CLPB

(Thermus
thermophilus) 		PF00004
(AAA) 		5 LEU A 291
PHE A 324
ILE A 314
GLY A 304
LEU A 232
 None
 1.16A 5fsaA-4hseA:
undetectable		 5fsaA-4hseA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inz SOLUBLE EPOXIDE
HYDROLASE

(Bacillus
megaterium) 		PF00561
(Abhydrolase_1) 		5 ALA A 186
TYR A 187
LEU A  55
ILE A  72
GLY A 103
 None
 1.12A 5fsaA-4inzA:
undetectable		 5fsaA-4inzA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbd PROLINE RACEMASE

(Pseudomonas
putida) 		PF05544
(Pro_racemase) 		5 ALA A 230
LEU A  50
ILE A   4
PHE A  79
HIS A  90
 None
None
None
None
CIT  A 401 (-3.7A)
 1.07A 5fsaA-4jbdA:
undetectable		 5fsaA-4jbdA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7a UNCHARACTERIZED
PROTEIN

(Bacteroides
caccae) 		PF15890
(Peptidase_Mx1) 		5 ALA A 217
LEU A 233
GLY A 107
LEU A 176
HIS A 177
 None
 1.21A 5fsaA-4l7aA:
undetectable		 5fsaA-4l7aA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Klebsiella
pneumoniae) 		PF02826
(2-Hacid_dh_C) 		5 TYR A 158
LEU A 153
PHE A  98
LEU A 106
PHE A 135
 None
 0.97A 5fsaA-4n18A:
undetectable		 5fsaA-4n18A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		5 LEU A 333
ILE A 325
PHE A 365
GLY A  78
LEU A 358
 None
 0.97A 5fsaA-4n7tA:
undetectable		 5fsaA-4n7tA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh1 L-IDITOL
2-DEHYDROGENASE

([Clostridium]
scindens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 153
LEU A 336
GLY A  54
HIS A  73
PHE A 129
 None
None
None
ZN  A 401 (-3.5A)
None
 1.16A 5fsaA-4oh1A:
undetectable		 5fsaA-4oh1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcw FILAGGRIN

(Homo sapiens) 		PF01023
(S_100) 		5 LEU A  80
ILE A  10
PHE A  40
LEU A  60
HIS A  59
 2PE  A 103 (-4.3A)
None
None
2PE  A 103 ( 4.9A)
None
 1.04A 5fsaA-4pcwA:
undetectable		 5fsaA-4pcwA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		5 PHE A 366
ILE A 143
PHE A 381
LEU A  29
PHE A 156
 None
 1.05A 5fsaA-4us4A:
undetectable		 5fsaA-4us4A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy6 HISTIDINE-SPECIFIC
METHYLTRANSFERASE
EGTD

(Mycolicibacterium
smegmatis) 		PF10017
(Methyltransf_33) 		5 ALA A  24
LEU A 167
PHE A 159
PHE A 142
GLY A  86
 None
None
None
SAH  A 801 (-3.4A)
SAH  A 801 (-3.0A)
 1.21A 5fsaA-4uy6A:
2.1		 5fsaA-4uy6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8i PROBABLE
SPHINGOSINE-1-PHOSPH
ATE LYASE

(Legionella
pneumophila) 		PF00282
(Pyridoxal_deC) 		5 ALA A 193
LEU A 372
PHE A 206
GLY A 331
LEU A 358
 None
 1.13A 5fsaA-4w8iA:
undetectable		 5fsaA-4w8iA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi8 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS

(Bartonella
clarridgeiae) 		PF02661
(Fic) 		5 ALA A  82
TYR A  75
PHE A 207
ILE A 210
PHE A 139
 None
 1.19A 5fsaA-4xi8A:
undetectable		 5fsaA-4xi8A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce6 FACT-SPT16

(Cicer arietinum) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 ALA A 327
TYR A 328
PHE A 382
ILE A 378
GLY A 302
 None
 1.09A 5fsaA-5ce6A:
undetectable		 5fsaA-5ce6A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		5 PHE A 224
PHE A 220
GLY A 275
LEU A 180
PHE A 164
 None
 1.19A 5fsaA-5d3oA:
undetectable		 5fsaA-5d3oA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		5 TYR A2221
PHE A2251
ILE A2250
PHE A2284
PHE A2168
 None
 1.20A 5fsaA-5fu7A:
undetectable		 5fsaA-5fu7A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5a GLUTATHIONE
S-TRANSFERASE U25

(Arabidopsis
thaliana) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		5 ALA A 116
LEU A 132
PHE A 128
GLY A 186
PHE A 173
 None
 1.14A 5fsaA-5g5aA:
undetectable		 5fsaA-5g5aA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmt ALGINATE LYASE

(Aplysia kurodai) 		no annotation 5 ILE A 200
PHE A 174
PHE A 253
GLY A 137
PHE A 232
 None
 1.13A 5fsaA-5gmtA:
undetectable		 5fsaA-5gmtA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtk BETAINE-ALDEHYDE
DEHYDROGENASE

(Bacillus cereus) 		PF00171
(Aldedh) 		5 ALA A  91
LEU A 190
ILE A  59
GLY A 222
LEU A 201
 None
 1.03A 5fsaA-5gtkA:
undetectable		 5fsaA-5gtkA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		5 TYR B1231
ILE B1161
PHE B1143
GLY B1171
PHE B1197
 None
 1.21A 5fsaA-5gztB:
undetectable		 5fsaA-5gztB:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		5 TYR A1231
ILE A1161
PHE A1143
GLY A1171
PHE A1197
 None
 1.17A 5fsaA-5gzuA:
undetectable		 5fsaA-5gzuA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6b PUTATIVE SECRETED
LIPASE

(Streptomyces
sp. W007) 		PF01674
(Lipase_2) 		5 ALA A  97
TYR A  20
LEU A  87
ILE A  80
GLY A 112
 None
 1.14A 5fsaA-5h6bA:
undetectable		 5fsaA-5h6bA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 5 LEU A 156
PHE A 226
ILE A 229
PHE A 171
HIS A  35
 None
 1.11A 5fsaA-5h7jA:
undetectable		 5fsaA-5h7jA:
10.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		11 ALA A  69
TYR A  72
TYR A 126
LEU A 129
PHE A 134
ILE A 139
PHE A 236
GLY A 314
LEU A 380
HIS A 381
PHE A 384
 None
None
VOR  A 602 ( 3.8A)
None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
VOR  A 602 (-4.0A)
None
None
 0.67A 5fsaA-5hs1A:
55.8		 5fsaA-5hs1A:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		11 ALA A  69
TYR A  72
TYR A 126
LEU A 129
PHE A 134
ILE A 139
PHE A 236
PHE A 241
GLY A 314
HIS A 381
PHE A 384
 None
None
VOR  A 602 ( 3.8A)
None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
None
VOR  A 602 (-3.0A)
None
None
 0.63A 5fsaA-5hs1A:
55.8		 5fsaA-5hs1A:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		12 ALA A  70
TYR A  73
TYR A 127
LEU A 130
PHE A 135
ILE A 140
PHE A 237
PHE A 242
GLY A 315
LEU A 381
HIS A 382
PHE A 385
 1YN  A 602 (-3.4A)
1YN  A 602 (-4.9A)
1YN  A 602 ( 3.8A)
None
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 4.5A)
1YN  A 602 ( 3.6A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-4.8A)
 0.72A 5fsaA-5jlcA:
54.7		 5fsaA-5jlcA:
62.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp7 ACETYL-COA
ACETYLTRANSFERASE

(Bacillus
subtilis) 		no annotation 5 ALA H 124
TYR H 123
TYR H 236
PHE H 320
ILE H 242
 None
 1.05A 5fsaA-5lp7H:
undetectable		 5fsaA-5lp7H:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlh -

(-) 		no annotation 5 ILE A 350
PHE A 282
GLY A 239
LEU A 221
PHE A 207
 XOG  A 402 (-4.8A)
None
None
None
None
 1.11A 5fsaA-5mlhA:
undetectable		 5fsaA-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msc CARBOXYLIC ACID
REDUCTASE

(Nocardia
iowensis) 		PF00501
(AMP-binding) 		5 ALA A 140
LEU A 307
PHE A 319
GLY A  62
LEU A  93
 None
 1.22A 5fsaA-5mscA:
undetectable		 5fsaA-5mscA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mxp -

(-) 		no annotation 5 ALA A 225
TYR A 226
LEU A 210
ILE A 173
PHE A 141
 None
None
ACT  A 401 ( 4.9A)
None
None
 1.15A 5fsaA-5mxpA:
undetectable		 5fsaA-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 ALA B 258
LEU B 950
PHE B 118
GLY B 476
PHE B 423
 None
 1.15A 5fsaA-5nd1B:
undetectable		 5fsaA-5nd1B:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o34 ENOYL-COA HYDRATASE
CARB HOMOLOGUE

(Streptomyces
cattleya) 		no annotation 5 ALA A  86
LEU A  95
ILE A 146
PHE A  60
GLY A 154
 None
 1.14A 5fsaA-5o34A:
undetectable		 5fsaA-5o34A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 5 ALA A  99
LEU A 110
ILE A 144
PHE A  85
GLY A  49
 KCX  A 130 ( 4.1A)
None
None
None
None
 1.14A 5fsaA-5oynA:
undetectable		 5fsaA-5oynA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svd NUCLEOLAR PROTEIN 9

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 TYR A 497
LEU A 494
PHE A 490
PHE A 501
GLY A 424
 TYR  A 497 ( 1.3A)
LEU  A 494 ( 0.6A)
PHE  A 490 ( 1.3A)
PHE  A 501 ( 1.3A)
GLY  A 424 ( 0.0A)
 1.11A 5fsaA-5svdA:
undetectable		 5fsaA-5svdA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4l ADENYLOSUCCINATE
LYASE

(Cryptococcus
neoformans) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 ALA A 259
PHE A  21
ILE A 334
GLY A 120
LEU A 179
 None
 1.12A 5fsaA-5v4lA:
undetectable		 5fsaA-5v4lA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu BNAB NIH45-46 SCFV
HEAVY CHAIN
BNAB NIH45-46 SCFV
LIGHT CHAIN

(Homo sapiens) 		no annotation 5 ALA D  60
TYR E  34
PHE E  92
GLY E  49
PHE D 104
 None
 1.20A 5fsaA-5wduD:
undetectable		 5fsaA-5wduD:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whr INDOLEAMINE
2,3-DIOXYGENASE 1

(Homo sapiens) 		no annotation 5 ALA A 338
PHE A 226
PHE A 214
GLY A 378
LEU A 388
 None
HEM  A 501 ( 4.0A)
HEM  A 501 (-4.0A)
AOJ  A 502 (-3.3A)
HEM  A 501 ( 4.8A)
 1.20A 5fsaA-5whrA:
0.9		 5fsaA-5whrA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xep CHITINASE-3-LIKE
PROTEIN 1

(Mus musculus) 		no annotation 5 ILE A  55
PHE A 107
GLY A 135
LEU A  67
PHE A 102
 None
 1.21A 5fsaA-5xepA:
undetectable		 5fsaA-5xepA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xep CHITINASE-3-LIKE
PROTEIN 1

(Mus musculus) 		no annotation 5 LEU A 138
ILE A  55
GLY A 135
LEU A  67
PHE A 102
 None
 1.20A 5fsaA-5xepA:
undetectable		 5fsaA-5xepA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au1 PUTATIVE HEMIN
STORAGE PROTEIN

(Bordetella
bronchiseptica) 		no annotation 5 TYR A 458
LEU A 461
PHE A 467
PHE A 376
GLY A 469
 None
 1.22A 5fsaA-6au1A:
undetectable		 5fsaA-6au1A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnp UNCONVENTIONAL
MYOSIN-VI

(Sus scrofa) 		no annotation 5 ALA I 422
PHE I 577
ILE I 579
PHE I 543
PHE I 647
 None
 1.19A 5fsaA-6bnpI:
undetectable		 5fsaA-6bnpI:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Danio rerio;
Eptatretus
burgeri) 		no annotation 5 LEU A 145
PHE A 166
GLY A 139
LEU A 111
PHE A  92
 None
 1.21A 5fsaA-6bxaA:
undetectable		 5fsaA-6bxaA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbr -

(-) 		no annotation 5 LEU A 679
PHE A 681
ILE A 572
PHE A 990
PHE A 576
 None
 1.21A 5fsaA-6dbrA:
undetectable		 5fsaA-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eq8 PERIPLASMIC
ALPHA-GALACTOSIDE-BI
NDING PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 5 ALA D 452
ILE D 420
GLY D 611
LEU D 607
PHE D   9
 None
 1.05A 5fsaA-6eq8D:
undetectable		 5fsaA-6eq8D:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 5 TYR A2330
ILE A2282
GLY A2463
LEU A2450
HIS A2452
 None
 1.19A 5fsaA-6fb3A:
undetectable		 5fsaA-6fb3A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 5 PHE A 313
ILE A 734
PHE A 335
PHE A 982
PHE A 977
 None
None
ZQU  A1304 ( 3.8A)
ZQU  A1305 ( 4.6A)
None
 1.08A 5fsaA-6fn1A:
undetectable		 5fsaA-6fn1A:
10.52