SIMILAR PATTERNS OF AMINO ACIDS FOR 5FSA_A_X2NA590

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0c XYLOSE ISOMERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF01261
(AP_endonuc_2) 		5 LEU A 335
PHE A 330
PHE A 362
GLY A 292
LEU A 282
 None
 1.11A 5fsaA-1a0cA:
0.0		 5fsaA-1a0cA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0e XYLOSE ISOMERASE

(Thermotoga
neapolitana) 		PF01261
(AP_endonuc_2) 		5 LEU A 335
PHE A 330
PHE A 362
GLY A 292
LEU A 282
 None
 1.07A 5fsaA-1a0eA:
0.0		 5fsaA-1a0eA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhd UTROPHIN

(Homo sapiens) 		PF00307
(CH) 		5 TYR A 246
LEU A 247
GLY A 182
LEU A 189
HIS A 192
 None
 1.06A 5fsaA-1bhdA:
undetectable		 5fsaA-1bhdA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)

(Pedobacter
heparinus) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 ALA A 355
TYR A 356
LEU A 617
ILE A 650
HIS A 351
 None
 1.09A 5fsaA-1cb8A:
0.0		 5fsaA-1cb8A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpb DIHYDROLIPOYL-TRANSA
CETYLASE

(Azotobacter
vinelandii) 		PF00198
(2-oxoacid_dh) 		5 LEU A 477
PHE A 555
ILE A 503
PHE A 621
LEU A 629
 None
 1.08A 5fsaA-1dpbA:
undetectable		 5fsaA-1dpbA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gux RETINOBLASTOMA
PROTEIN

(Homo sapiens) 		PF01858
(RB_A) 		5 ALA A 562
LEU A 550
ILE A 382
PHE A 535
PHE A 514
 None
 1.02A 5fsaA-1guxA:
undetectable		 5fsaA-1guxA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkg HEXOKINASE A

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 LEU A 133
ILE A 187
PHE A 175
GLY A 434
LEU A  74
 None
 1.17A 5fsaA-1hkgA:
1.2		 5fsaA-1hkgA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 ALA A 111
LEU A 137
ILE A  55
GLY A 134
LEU A  66
 None
 1.04A 5fsaA-1hkkA:
undetectable		 5fsaA-1hkkA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		5 TYR B   4
LEU B  80
PHE B  71
GLY B 102
HIS B  53
 None
 1.20A 5fsaA-1htrB:
0.0		 5fsaA-1htrB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 ALA A 343
LEU A 282
PHE A 306
GLY A 600
LEU A 407
 None
 0.98A 5fsaA-1ksiA:
0.0		 5fsaA-1ksiA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 ALA A1509
ILE A1790
PHE A1876
GLY A1874
LEU A1594
 None
 1.18A 5fsaA-1larA:
0.0		 5fsaA-1larA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lln ANTIVIRAL PROTEIN 3

(Phytolacca
americana) 		PF00161
(RIP) 		5 ALA A 149
LEU A  61
ILE A   2
LEU A 137
PHE A  59
 None
None
None
MLY  A 134 ( 4.8A)
None
 1.21A 5fsaA-1llnA:
undetectable		 5fsaA-1llnA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrf REGULATORY PROTEIN
BLAR1

(Bacillus
licheniformis) 		PF00905
(Transpeptidase) 		5 TYR A 596
LEU A 587
PHE A 567
PHE A 554
GLY A 538
 None
 1.05A 5fsaA-1nrfA:
undetectable		 5fsaA-1nrfA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohe CDC14B2 PHOSPHATASE

(Homo sapiens) 		PF00782
(DSPc)
PF14671
(DSPn) 		5 TYR A 268
ILE A 220
PHE A 299
HIS A 280
PHE A 227
 None
 1.17A 5fsaA-1oheA:
undetectable		 5fsaA-1oheA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 ALA A 415
PHE A 268
ILE A 249
PHE A 527
HIS A 579
 FAD  A 701 (-3.6A)
None
None
None
None
 1.07A 5fsaA-1ps9A:
undetectable		 5fsaA-1ps9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 ALA A 111
LEU A 137
ILE A  55
GLY A 134
LEU A  66
 None
 1.03A 5fsaA-1wb0A:
undetectable		 5fsaA-1wb0A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		5 ALA A 231
LEU A  96
ILE A 127
GLY A  81
PHE A  37
 None
 1.06A 5fsaA-1x1nA:
undetectable		 5fsaA-1x1nA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		5 ALA A 121
LEU A 240
PHE A 205
ILE A 216
LEU A 148
 None
 0.92A 5fsaA-1ycnA:
undetectable		 5fsaA-1ycnA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE

(Clostridium
acetobutylicum) 		PF04616
(Glyco_hydro_43) 		5 ALA A 392
TYR A 532
ILE A  73
PHE A 510
LEU A  51
 None
 1.21A 5fsaA-1yi7A:
undetectable		 5fsaA-1yi7A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yka MONOTHIOL
GLUTAREDOXIN YDHD

(Escherichia
coli) 		PF00462
(Glutaredoxin) 		5 TYR A  49
LEU A  19
ILE A  52
PHE A  47
GLY A  31
 None
 1.05A 5fsaA-1ykaA:
undetectable		 5fsaA-1ykaA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 ALA A 794
ILE A 686
GLY A 710
HIS A 804
PHE A 724
 None
 1.17A 5fsaA-2b3xA:
undetectable		 5fsaA-2b3xA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw7 ENDONUCLEASE
PI-PKOII

(Thermococcus
kodakarensis) 		PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		5 ALA A 445
TYR A 446
PHE A 436
GLY A 378
LEU A 394
 None
 1.22A 5fsaA-2cw7A:
undetectable		 5fsaA-2cw7A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		5 ALA A 263
TYR A 270
LEU A 167
PHE A 309
GLY A 251
 None
NAD  A5555 (-3.6A)
None
None
None
 1.21A 5fsaA-2fknA:
0.7		 5fsaA-2fknA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o62 HYPOTHETICAL PROTEIN

(Nostoc
punctiforme) 		PF12204
(DUF3598) 		5 LEU A 116
ILE A 198
PHE A 110
GLY A  26
LEU A 106
 GOL  A 277 (-4.4A)
None
None
None
None
 1.07A 5fsaA-2o62A:
undetectable		 5fsaA-2o62A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pof CDP-DIACYLGLYCEROL
PYROPHOSPHATASE

(Escherichia
coli) 		PF02611
(CDH) 		5 ALA A 237
PHE A 193
GLY A  63
LEU A  78
PHE A 101
 None
 1.04A 5fsaA-2pofA:
undetectable		 5fsaA-2pofA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qga ADENYLOSUCCINATE
LYASE

(Plasmodium
vivax) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 ALA B 202
TYR B 239
LEU B 117
PHE B  50
PHE B 211
 None
 1.14A 5fsaA-2qgaB:
1.6		 5fsaA-2qgaB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhg TYROCIDINE
SYNTHETASE A

(Brevibacillus
brevis) 		PF00668
(Condensation) 		5 ALA A 278
LEU A 264
ILE A 259
PHE A 367
GLY A 415
 None
 1.19A 5fsaA-2xhgA:
undetectable		 5fsaA-2xhgA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb4 AMIDOHYDROLASE

(Chromobacterium
violaceum) 		PF02811
(PHP) 		5 ALA A  16
ILE A 280
PHE A   8
GLY A  80
LEU A  45
 None
 1.21A 5fsaA-2yb4A:
undetectable		 5fsaA-2yb4A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be8 NEUROLIGIN-4,
X-LINKED

(Homo sapiens) 		PF00135
(COesterase) 		5 LEU A 132
ILE A 185
PHE A 128
GLY A 174
LEU A 205
 None
None
None
PO4  A 623 ( 3.6A)
None
 1.01A 5fsaA-3be8A:
undetectable		 5fsaA-3be8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bin BAND 4.1-LIKE
PROTEIN 3

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 ALA A 280
LEU A 145
PHE A 136
GLY A 152
LEU A 117
 None
 1.17A 5fsaA-3binA:
undetectable		 5fsaA-3binA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		5 TYR A 204
LEU A 206
ILE A 196
GLY A 121
HIS A 188
 None
 1.09A 5fsaA-3c0kA:
undetectable		 5fsaA-3c0kA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2u XYLOSIDASE/ARABINOSI
DASE

(Selenomonas
ruminantium) 		PF04616
(Glyco_hydro_43)
PF07081
(DUF1349) 		5 ALA A 394
TYR A 534
ILE A  72
PHE A 512
LEU A  50
 None
 1.21A 5fsaA-3c2uA:
undetectable		 5fsaA-3c2uA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6t ASPARTATE
AMINOTRANSFERASE

(Lactobacillus
acidophilus) 		PF00155
(Aminotran_1_2) 		5 ALA A 264
LEU A 306
ILE A 146
GLY A 322
PHE A 293
 None
 1.17A 5fsaA-3f6tA:
undetectable		 5fsaA-3f6tA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnc PUTATIVE
ACETYLTRANSFERASE

(Listeria
innocua) 		PF13673
(Acetyltransf_10) 		5 ALA A  56
LEU A  84
PHE A 130
PHE A  87
GLY A  99
 None
None
MLI  A 162 (-4.7A)
None
MLI  A 162 (-3.4A)
 1.19A 5fsaA-3fncA:
undetectable		 5fsaA-3fncA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gka N-ETHYLMALEIMIDE
REDUCTASE

(Burkholderia
pseudomallei) 		PF00724
(Oxidored_FMN) 		5 ALA A 167
LEU A 215
ILE A 207
GLY A 253
LEU A 234
 None
 1.04A 5fsaA-3gkaA:
undetectable		 5fsaA-3gkaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		5 ALA A 345
TYR A 539
PHE A 253
PHE A 278
LEU A 432
 None
 1.18A 5fsaA-3hjrA:
undetectable		 5fsaA-3hjrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN

(Streptomyces
coelicolor) 		PF01547
(SBP_bac_1) 		5 PHE A 154
ILE A 320
PHE A 351
GLY A  54
LEU A  59
 None
 1.15A 5fsaA-3i3vA:
undetectable		 5fsaA-3i3vA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3imh GALACTOSE-1-EPIMERAS
E

(Lactobacillus
acidophilus) 		PF01263
(Aldose_epim) 		5 ALA A 211
LEU A 273
PHE A 244
GLY A 293
LEU A 227
 None
 1.08A 5fsaA-3imhA:
undetectable		 5fsaA-3imhA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES1

(Plasmodium
falciparum) 		PF01015
(Ribosomal_S3Ae) 		5 ALA B  71
LEU B  32
ILE B  91
PHE B  43
GLY B  63
 None
 1.13A 5fsaA-3j7aB:
undetectable		 5fsaA-3j7aB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kya PUTATIVE PHOSPHATASE

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		5 ALA A 223
TYR A 177
ILE A 189
PHE A 215
PHE A 256
 None
 1.12A 5fsaA-3kyaA:
undetectable		 5fsaA-3kyaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng0 GLUTAMINE SYNTHETASE

(Synechocystis
sp. PCC 6803) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		5 ALA A 133
ILE A 123
PHE A 129
GLY A 385
LEU A 360
 None
 1.16A 5fsaA-3ng0A:
undetectable		 5fsaA-3ng0A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o9p PERIPLASMIC MUREIN
PEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		5 PHE A 424
PHE A 109
GLY A 269
LEU A  34
PHE A 162
 None
None
None
MHI  A 516 (-3.7A)
None
 1.13A 5fsaA-3o9pA:
undetectable		 5fsaA-3o9pA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otn SUSD SUPERFAMILY
PROTEIN

(Parabacteroides
distasonis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 ALA A 213
TYR A 382
TYR A 184
GLY A 233
PHE A 151
 None
 1.03A 5fsaA-3otnA:
undetectable		 5fsaA-3otnA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pic CIP2

(Trichoderma
reesei) 		no annotation 5 PHE A 213
ILE A 195
PHE A 177
GLY A 251
LEU A 155
 None
 1.19A 5fsaA-3picA:
undetectable		 5fsaA-3picA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q63 MLL2253 PROTEIN

(Mesorhizobium
japonicum) 		PF08327
(AHSA1) 		5 ALA A  67
LEU A  38
PHE A 131
LEU A  61
PHE A  51
 None
 1.20A 5fsaA-3q63A:
undetectable		 5fsaA-3q63A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qre ENOYL-COA HYDRATASE,
ECHA12_1

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 ALA A  50
LEU A  59
ILE A 116
PHE A  24
GLY A 124
 None
 1.18A 5fsaA-3qreA:
undetectable		 5fsaA-3qreA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 ALA K  69
LEU K  19
ILE J 102
GLY L 601
LEU N 209
 None
 1.22A 5fsaA-3rkoK:
2.3		 5fsaA-3rkoK:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		5 ALA X 389
LEU X 272
ILE X 265
PHE X 295
LEU X  81
 None
 0.96A 5fsaA-3ss7X:
undetectable		 5fsaA-3ss7X:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v44 TOLL-LIKE RECEPTOR
5B AND VARIABLE
LYMPHOCYTE RECEPTOR
B.61 CHIMERIC
PROTEIN

(Danio rerio;
Eptatretus
burgeri) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU A 145
PHE A 166
GLY A 139
LEU A 111
PHE A  92
 None
 1.20A 5fsaA-3v44A:
undetectable		 5fsaA-3v44A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsk PENICILLIN-BINDING
PROTEIN 3

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 ALA A  46
LEU A  73
ILE A 320
GLY A 552
LEU A 284
 None
 1.13A 5fsaA-3vskA:
undetectable		 5fsaA-3vskA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7g CATALASE

(Corynebacterium
glutamicum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 ALA A  93
LEU A 129
PHE A 108
PHE A 127
PHE A 131
 None
 1.21A 5fsaA-4b7gA:
undetectable		 5fsaA-4b7gA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnh UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF06187
(DUF993) 		5 ALA A 350
LEU A 334
PHE A 330
LEU A 383
HIS A 386
 None
 1.13A 5fsaA-4dnhA:
undetectable		 5fsaA-4dnhA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		5 ALA A 551
LEU A 628
PHE A 666
PHE A 654
LEU A 616
 None
 1.19A 5fsaA-4ecnA:
undetectable		 5fsaA-4ecnA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1l ANI2.3 TCR A CHAIN
ANI2.3 TCR B CHAIN

(Escherichia
coli) 		PF07686
(V-set) 		5 ALA H  90
TYR H  31
TYR G  31
PHE G  33
GLY G  27
 None
 1.20A 5fsaA-4h1lH:
undetectable		 5fsaA-4h1lH:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hse CHAPERONE PROTEIN
CLPB

(Thermus
thermophilus) 		PF00004
(AAA) 		5 LEU A 291
PHE A 324
ILE A 314
GLY A 304
LEU A 232
 None
 1.16A 5fsaA-4hseA:
undetectable		 5fsaA-4hseA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inz SOLUBLE EPOXIDE
HYDROLASE

(Bacillus
megaterium) 		PF00561
(Abhydrolase_1) 		5 ALA A 186
TYR A 187
LEU A  55
ILE A  72
GLY A 103
 None
 1.12A 5fsaA-4inzA:
undetectable		 5fsaA-4inzA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbd PROLINE RACEMASE

(Pseudomonas
putida) 		PF05544
(Pro_racemase) 		5 ALA A 230
LEU A  50
ILE A   4
PHE A  79
HIS A  90
 None
None
None
None
CIT  A 401 (-3.7A)
 1.07A 5fsaA-4jbdA:
undetectable		 5fsaA-4jbdA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7a UNCHARACTERIZED
PROTEIN

(Bacteroides
caccae) 		PF15890
(Peptidase_Mx1) 		5 ALA A 217
LEU A 233
GLY A 107
LEU A 176
HIS A 177
 None
 1.21A 5fsaA-4l7aA:
undetectable		 5fsaA-4l7aA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Klebsiella
pneumoniae) 		PF02826
(2-Hacid_dh_C) 		5 TYR A 158
LEU A 153
PHE A  98
LEU A 106
PHE A 135
 None
 0.97A 5fsaA-4n18A:
undetectable		 5fsaA-4n18A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		5 LEU A 333
ILE A 325
PHE A 365
GLY A  78
LEU A 358
 None
 0.97A 5fsaA-4n7tA:
undetectable		 5fsaA-4n7tA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh1 L-IDITOL
2-DEHYDROGENASE

([Clostridium]
scindens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 153
LEU A 336
GLY A  54
HIS A  73
PHE A 129
 None
None
None
ZN  A 401 (-3.5A)
None
 1.16A 5fsaA-4oh1A:
undetectable		 5fsaA-4oh1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcw FILAGGRIN

(Homo sapiens) 		PF01023
(S_100) 		5 LEU A  80
ILE A  10
PHE A  40
LEU A  60
HIS A  59
 2PE  A 103 (-4.3A)
None
None
2PE  A 103 ( 4.9A)
None
 1.04A 5fsaA-4pcwA:
undetectable		 5fsaA-4pcwA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		5 PHE A 366
ILE A 143
PHE A 381
LEU A  29
PHE A 156
 None
 1.05A 5fsaA-4us4A:
undetectable		 5fsaA-4us4A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy6 HISTIDINE-SPECIFIC
METHYLTRANSFERASE
EGTD

(Mycolicibacterium
smegmatis) 		PF10017
(Methyltransf_33) 		5 ALA A  24
LEU A 167
PHE A 159
PHE A 142
GLY A  86
 None
None
None
SAH  A 801 (-3.4A)
SAH  A 801 (-3.0A)
 1.21A 5fsaA-4uy6A:
2.1		 5fsaA-4uy6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8i PROBABLE
SPHINGOSINE-1-PHOSPH
ATE LYASE

(Legionella
pneumophila) 		PF00282
(Pyridoxal_deC) 		5 ALA A 193
LEU A 372
PHE A 206
GLY A 331
LEU A 358
 None
 1.13A 5fsaA-4w8iA:
undetectable		 5fsaA-4w8iA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi8 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS

(Bartonella
clarridgeiae) 		PF02661
(Fic) 		5 ALA A  82
TYR A  75
PHE A 207
ILE A 210
PHE A 139
 None
 1.19A 5fsaA-4xi8A:
undetectable		 5fsaA-4xi8A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce6 FACT-SPT16

(Cicer arietinum) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 ALA A 327
TYR A 328
PHE A 382
ILE A 378
GLY A 302
 None
 1.09A 5fsaA-5ce6A:
undetectable		 5fsaA-5ce6A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		5 PHE A 224
PHE A 220
GLY A 275
LEU A 180
PHE A 164
 None
 1.19A 5fsaA-5d3oA:
undetectable		 5fsaA-5d3oA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		5 TYR A2221
PHE A2251
ILE A2250
PHE A2284
PHE A2168
 None
 1.20A 5fsaA-5fu7A:
undetectable		 5fsaA-5fu7A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5a GLUTATHIONE
S-TRANSFERASE U25

(Arabidopsis
thaliana) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		5 ALA A 116
LEU A 132
PHE A 128
GLY A 186
PHE A 173
 None
 1.14A 5fsaA-5g5aA:
undetectable		 5fsaA-5g5aA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmt ALGINATE LYASE

(Aplysia kurodai) 		no annotation 5 ILE A 200
PHE A 174
PHE A 253
GLY A 137
PHE A 232
 None
 1.13A 5fsaA-5gmtA:
undetectable		 5fsaA-5gmtA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtk BETAINE-ALDEHYDE
DEHYDROGENASE

(Bacillus cereus) 		PF00171
(Aldedh) 		5 ALA A  91
LEU A 190
ILE A  59
GLY A 222
LEU A 201
 None
 1.03A 5fsaA-5gtkA:
undetectable		 5fsaA-5gtkA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		5 TYR B1231
ILE B1161
PHE B1143
GLY B1171
PHE B1197
 None
 1.21A 5fsaA-5gztB:
undetectable		 5fsaA-5gztB:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		5 TYR A1231
ILE A1161
PHE A1143
GLY A1171
PHE A1197
 None
 1.17A 5fsaA-5gzuA:
undetectable		 5fsaA-5gzuA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6b PUTATIVE SECRETED
LIPASE

(Streptomyces
sp. W007) 		PF01674
(Lipase_2) 		5 ALA A  97
TYR A  20
LEU A  87
ILE A  80
GLY A 112
 None
 1.14A 5fsaA-5h6bA:
undetectable		 5fsaA-5h6bA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 5 LEU A 156
PHE A 226
ILE A 229
PHE A 171
HIS A  35
 None
 1.11A 5fsaA-5h7jA:
undetectable		 5fsaA-5h7jA:
10.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		11 ALA A  69
TYR A  72
TYR A 126
LEU A 129
PHE A 134
ILE A 139
PHE A 236
GLY A 314
LEU A 380
HIS A 381
PHE A 384
 None
None
VOR  A 602 ( 3.8A)
None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
VOR  A 602 (-4.0A)
None
None
 0.67A 5fsaA-5hs1A:
55.8		 5fsaA-5hs1A:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		11 ALA A  69
TYR A  72
TYR A 126
LEU A 129
PHE A 134
ILE A 139
PHE A 236
PHE A 241
GLY A 314
HIS A 381
PHE A 384
 None
None
VOR  A 602 ( 3.8A)
None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
None
VOR  A 602 (-3.0A)
None
None
 0.63A 5fsaA-5hs1A:
55.8		 5fsaA-5hs1A:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		12 ALA A  70
TYR A  73
TYR A 127
LEU A 130
PHE A 135
ILE A 140
PHE A 237
PHE A 242
GLY A 315
LEU A 381
HIS A 382
PHE A 385
 1YN  A 602 (-3.4A)
1YN  A 602 (-4.9A)
1YN  A 602 ( 3.8A)
None
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 4.5A)
1YN  A 602 ( 3.6A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-4.8A)
 0.72A 5fsaA-5jlcA:
54.7		 5fsaA-5jlcA:
62.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp7 ACETYL-COA
ACETYLTRANSFERASE

(Bacillus
subtilis) 		no annotation 5 ALA H 124
TYR H 123
TYR H 236
PHE H 320
ILE H 242
 None
 1.05A 5fsaA-5lp7H:
undetectable		 5fsaA-5lp7H:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlh -

(-) 		no annotation 5 ILE A 350
PHE A 282
GLY A 239
LEU A 221
PHE A 207
 XOG  A 402 (-4.8A)
None
None
None
None
 1.11A 5fsaA-5mlhA:
undetectable		 5fsaA-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msc CARBOXYLIC ACID
REDUCTASE

(Nocardia
iowensis) 		PF00501
(AMP-binding) 		5 ALA A 140
LEU A 307
PHE A 319
GLY A  62
LEU A  93
 None
 1.22A 5fsaA-5mscA:
undetectable		 5fsaA-5mscA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mxp -

(-) 		no annotation 5 ALA A 225
TYR A 226
LEU A 210
ILE A 173
PHE A 141
 None
None
ACT  A 401 ( 4.9A)
None
None
 1.15A 5fsaA-5mxpA:
undetectable		 5fsaA-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 ALA B 258
LEU B 950
PHE B 118
GLY B 476
PHE B 423
 None
 1.15A 5fsaA-5nd1B:
undetectable		 5fsaA-5nd1B:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o34 ENOYL-COA HYDRATASE
CARB HOMOLOGUE

(Streptomyces
cattleya) 		no annotation 5 ALA A  86
LEU A  95
ILE A 146
PHE A  60
GLY A 154
 None
 1.14A 5fsaA-5o34A:
undetectable		 5fsaA-5o34A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 5 ALA A  99
LEU A 110
ILE A 144
PHE A  85
GLY A  49
 KCX  A 130 ( 4.1A)
None
None
None
None
 1.14A 5fsaA-5oynA:
undetectable		 5fsaA-5oynA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svd NUCLEOLAR PROTEIN 9

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 TYR A 497
LEU A 494
PHE A 490
PHE A 501
GLY A 424
 TYR  A 497 ( 1.3A)
LEU  A 494 ( 0.6A)
PHE  A 490 ( 1.3A)
PHE  A 501 ( 1.3A)
GLY  A 424 ( 0.0A)
 1.11A 5fsaA-5svdA:
undetectable		 5fsaA-5svdA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4l ADENYLOSUCCINATE
LYASE

(Cryptococcus
neoformans) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 ALA A 259
PHE A  21
ILE A 334
GLY A 120
LEU A 179
 None
 1.12A 5fsaA-5v4lA:
undetectable		 5fsaA-5v4lA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu BNAB NIH45-46 SCFV
HEAVY CHAIN
BNAB NIH45-46 SCFV
LIGHT CHAIN

(Homo sapiens) 		no annotation 5 ALA D  60
TYR E  34
PHE E  92
GLY E  49
PHE D 104
 None
 1.20A 5fsaA-5wduD:
undetectable		 5fsaA-5wduD:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whr INDOLEAMINE
2,3-DIOXYGENASE 1

(Homo sapiens) 		no annotation 5 ALA A 338
PHE A 226
PHE A 214
GLY A 378
LEU A 388
 None
HEM  A 501 ( 4.0A)
HEM  A 501 (-4.0A)
AOJ  A 502 (-3.3A)
HEM  A 501 ( 4.8A)
 1.20A 5fsaA-5whrA:
0.9		 5fsaA-5whrA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xep CHITINASE-3-LIKE
PROTEIN 1

(Mus musculus) 		no annotation 5 ILE A  55
PHE A 107
GLY A 135
LEU A  67
PHE A 102
 None
 1.21A 5fsaA-5xepA:
undetectable		 5fsaA-5xepA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xep CHITINASE-3-LIKE
PROTEIN 1

(Mus musculus) 		no annotation 5 LEU A 138
ILE A  55
GLY A 135
LEU A  67
PHE A 102
 None
 1.20A 5fsaA-5xepA:
undetectable		 5fsaA-5xepA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au1 PUTATIVE HEMIN
STORAGE PROTEIN

(Bordetella
bronchiseptica) 		no annotation 5 TYR A 458
LEU A 461
PHE A 467
PHE A 376
GLY A 469
 None
 1.22A 5fsaA-6au1A:
undetectable		 5fsaA-6au1A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnp UNCONVENTIONAL
MYOSIN-VI

(Sus scrofa) 		no annotation 5 ALA I 422
PHE I 577
ILE I 579
PHE I 543
PHE I 647
 None
 1.19A 5fsaA-6bnpI:
undetectable		 5fsaA-6bnpI:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Danio rerio;
Eptatretus
burgeri) 		no annotation 5 LEU A 145
PHE A 166
GLY A 139
LEU A 111
PHE A  92
 None
 1.21A 5fsaA-6bxaA:
undetectable		 5fsaA-6bxaA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbr -

(-) 		no annotation 5 LEU A 679
PHE A 681
ILE A 572
PHE A 990
PHE A 576
 None
 1.21A 5fsaA-6dbrA:
undetectable		 5fsaA-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eq8 PERIPLASMIC
ALPHA-GALACTOSIDE-BI
NDING PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 5 ALA D 452
ILE D 420
GLY D 611
LEU D 607
PHE D   9
 None
 1.05A 5fsaA-6eq8D:
undetectable		 5fsaA-6eq8D:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 5 TYR A2330
ILE A2282
GLY A2463
LEU A2450
HIS A2452
 None
 1.19A 5fsaA-6fb3A:
undetectable		 5fsaA-6fb3A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 5 PHE A 313
ILE A 734
PHE A 335
PHE A 982
PHE A 977
 None
None
ZQU  A1304 ( 3.8A)
ZQU  A1305 ( 4.6A)
None
 1.08A 5fsaA-6fn1A:
undetectable		 5fsaA-6fn1A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)

(Salmonella
enterica) 		PF00180
(Iso_dh) 		3 PRO A  56
ILE A  15
SER A  88
 None
 0.81A 5fsaA-1cnzA:
0.0		 5fsaA-1cnzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		3 PRO A 120
ILE A 688
SER A 127
 None
 0.61A 5fsaA-1e1cA:
0.0		 5fsaA-1e1cA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		3 PRO A 233
ILE A 106
SER A 178
 None
 0.68A 5fsaA-1fizA:
0.0		 5fsaA-1fizA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 PRO A 212
ILE A  33
SER A 340
 None
 0.70A 5fsaA-1g0dA:
0.0		 5fsaA-1g0dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h14 ENDO-1,4-BETA-XYLANA
SE

(Pseudoalteromonas
haloplanktis) 		PF01270
(Glyco_hydro_8) 		3 PRO A 143
ILE A 173
SER A 192
 None
 0.68A 5fsaA-1h14A:
0.0		 5fsaA-1h14A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882

(Lophonetta
specularioides) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		3 PRO A  57
ILE A  70
SER A  32
 None
 0.79A 5fsaA-1h8lA:
0.0		 5fsaA-1h8lA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		3 PRO A 471
ILE A 126
SER A 464
 None
 0.71A 5fsaA-1iq0A:
0.0		 5fsaA-1iq0A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqq S3-RNASE

(Pyrus pyrifolia) 		PF00445
(Ribonuclease_T2) 		3 PRO A  37
ILE A 167
SER A  90
 None
 0.76A 5fsaA-1iqqA:
0.0		 5fsaA-1iqqA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzt HYPOTHETICAL 27.5
KDA PROTEIN IN
SPX19-GCR2
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF03853
(YjeF_N) 		3 PRO A 175
ILE A 166
SER A 205
 None
 0.79A 5fsaA-1jztA:
0.0		 5fsaA-1jztA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0q SURFACE LAYER
PROTEIN

(Methanosarcina
mazei) 		PF00801
(PKD)
PF10282
(Lactonase) 		3 PRO A  41
ILE A  17
SER A  82
 None
 0.66A 5fsaA-1l0qA:
undetectable		 5fsaA-1l0qA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lml LEISHMANOLYSIN

(Leishmania
major) 		PF01457
(Peptidase_M8) 		3 PRO A 460
ILE A 335
SER A 462
 None
 0.73A 5fsaA-1lmlA:
undetectable		 5fsaA-1lmlA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnt OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		3 PRO A  76
ILE A 305
SER A 316
 None
 0.79A 5fsaA-1nntA:
undetectable		 5fsaA-1nntA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 PRO A  69
ILE A  94
SER A 113
 None
 0.79A 5fsaA-1nr0A:
undetectable		 5fsaA-1nr0A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw5 MODIFICATION
METHYLASE RSRI

(Rhodobacter
sphaeroides) 		PF01555
(N6_N4_Mtase) 		3 PRO A 228
ILE A 102
SER A 211
 None
 0.81A 5fsaA-1nw5A:
undetectable		 5fsaA-1nw5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 PRO A 106
ILE A  99
SER A 202
 None
 0.00A 5fsaA-1q5aA:
undetectable		 5fsaA-1q5aA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5f PYRUVATE OXIDASE

(Aerococcus
viridans) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 PRO A 544
ILE A 348
SER A 392
 None
None
TPP  A1602 (-2.7A)
 0.78A 5fsaA-1v5fA:
undetectable		 5fsaA-1v5fA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v77 HYPOTHETICAL PROTEIN
PH1877

(Pyrococcus
horikoshii) 		PF01876
(RNase_P_p30) 		3 PRO A 203
ILE A  34
SER A 198
 None
 0.64A 5fsaA-1v77A:
undetectable		 5fsaA-1v77A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		3 PRO A  82
ILE A  97
SER A 123
 None
 0.79A 5fsaA-1vf8A:
undetectable		 5fsaA-1vf8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpk DNA POLYMERASE III,
BETA SUBUNIT

(Thermotoga
maritima) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		3 PRO A 248
ILE A 353
SER A 344
 None
 0.65A 5fsaA-1vpkA:
undetectable		 5fsaA-1vpkA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA)
PF07737
(ATLF) 		3 PRO A 365
ILE A 462
SER A 354
 None
 0.76A 5fsaA-1xfuA:
1.3		 5fsaA-1xfuA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE

(Chlorobaculum
tepidum) 		PF04371
(PAD_porph) 		3 PRO A 299
ILE A  55
SER A 285
 None
 0.75A 5fsaA-1xknA:
undetectable		 5fsaA-1xknA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zan FAB AD11 LIGHT CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO L  40
ILE L  48
SER L 169
 None
 0.79A 5fsaA-1zanL:
undetectable		 5fsaA-1zanL:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aey FRUCTAN
1-EXOHYDROLASE IIA

(Cichorium
intybus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 PRO A 406
ILE A 476
SER A 400
 None
 0.78A 5fsaA-2aeyA:
undetectable		 5fsaA-2aeyA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be9 ASPARTATE
CARBAMOYLTRANSFERASE
REGULATORY CHAIN

(Sulfolobus
acidocaldarius) 		PF01948
(PyrI)
PF02748
(PyrI_C) 		3 PRO B 128
ILE B  78
SER B 121
 None
 0.70A 5fsaA-2be9B:
undetectable		 5fsaA-2be9B:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1

(Saccharomyces
cerevisiae) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 PRO A 353
ILE A 422
SER A 257
 None
 0.75A 5fsaA-2cvtA:
undetectable		 5fsaA-2cvtA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		3 PRO A  76
ILE A 305
SER A 316
 None
 0.80A 5fsaA-2d3iA:
undetectable		 5fsaA-2d3iA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg9 ADP-RIBOSYL CYCLASE
1

(Mus musculus) 		PF02267
(Rib_hydrolayse) 		3 PRO A 219
ILE A 250
SER A 261
 None
 0.80A 5fsaA-2eg9A:
undetectable		 5fsaA-2eg9A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Staphylococcus
aureus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		3 PRO B 147
ILE B 173
SER B  19
 None
 0.81A 5fsaA-2f2aB:
undetectable		 5fsaA-2f2aB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcg ANTIBACTERIAL
PROTEIN FALL-39,
CORE PEPTIDE

(Homo sapiens) 		PF12153
(CAP18_C) 		3 PRO F  33
ILE F  20
SER F  37
 None
 0.74A 5fsaA-2fcgF:
undetectable		 5fsaA-2fcgF:
4.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiy PROTEIN FDHE HOMOLOG

(Pseudomonas
aeruginosa) 		PF04216
(FdhE) 		3 PRO A 192
ILE A 138
SER A 226
 None
 0.78A 5fsaA-2fiyA:
undetectable		 5fsaA-2fiyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		3 PRO A 261
ILE A 151
SER A 328
 None
 0.77A 5fsaA-2fncA:
undetectable		 5fsaA-2fncA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h39 PROBABLE
GALACTOSE-1-PHOSPHAT
E URIDYL TRANSFERASE

(Arabidopsis
thaliana) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		3 PRO A  39
ILE A 248
SER A  22
 None
 0.77A 5fsaA-2h39A:
undetectable		 5fsaA-2h39A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE

(Homo sapiens) 		PF00171
(Aldedh) 		3 PRO A 751
ILE A 495
SER A 728
 None
 0.79A 5fsaA-2h5gA:
undetectable		 5fsaA-2h5gA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES

(Bacillus cereus) 		PF03486
(HI0933_like) 		3 PRO A 193
ILE A 231
SER A 354
 None
 0.80A 5fsaA-2i0zA:
undetectable		 5fsaA-2i0zA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 HYPOTHETICAL PROTEIN
YPL007C

(Saccharomyces
cerevisiae) 		PF12660
(zf-TFIIIC) 		3 PRO A 216
ILE A 158
SER A 218
 None
 0.81A 5fsaA-2j04A:
undetectable		 5fsaA-2j04A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 HYPOTHETICAL PROTEIN
YPL007C
YDR362CP

(Saccharomyces
cerevisiae) 		PF12660
(zf-TFIIIC)
no annotation 		3 PRO A 244
ILE A 234
SER B 457
 None
 0.77A 5fsaA-2j04A:
undetectable		 5fsaA-2j04A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		3 PRO A 417
ILE A  19
SER A 430
 None
 0.60A 5fsaA-2pi5A:
2.1		 5fsaA-2pi5A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 PRO A 969
ILE A 977
SER A 513
 None
 0.74A 5fsaA-2vdcA:
undetectable		 5fsaA-2vdcA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vtc CEL61B

(Trichoderma
reesei) 		PF03443
(Glyco_hydro_61) 		3 PRO A 152
ILE A  68
SER A 187
 None
 0.80A 5fsaA-2vtcA:
undetectable		 5fsaA-2vtcA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF13638
(PIN_4)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		3 PRO J 759
ILE J 807
SER J 296
 None
 0.65A 5fsaA-2wp8J:
undetectable		 5fsaA-2wp8J:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 PRO A 425
ILE A 414
SER A 614
 None
 0.78A 5fsaA-2xaxA:
undetectable		 5fsaA-2xaxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvn ASPERGILLUS
FUMIGATUS CHITINASE
A1

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		3 PRO A  65
ILE A  58
SER A 136
 None
 0.73A 5fsaA-2xvnA:
undetectable		 5fsaA-2xvnA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z87 CHONDROITIN SYNTHASE

(Escherichia
coli) 		PF00535
(Glycos_transf_2) 		3 PRO A 246
ILE A 265
SER A 286
 None
 0.73A 5fsaA-2z87A:
undetectable		 5fsaA-2z87A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 3 PRO A 445
ILE A 749
SER A 520
 None
 0.81A 5fsaA-3a0fA:
undetectable		 5fsaA-3a0fA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b98 PROSTAGLANDIN I2
SYNTHASE

(Danio rerio) 		PF00067
(p450) 		3 PRO A 205
ILE A 193
SER A 459
 None
 0.80A 5fsaA-3b98A:
30.3		 5fsaA-3b98A:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		3 PRO A 504
ILE A 534
SER A 474
 None
 0.81A 5fsaA-3ciyA:
undetectable		 5fsaA-3ciyA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clm TRANSALDOLASE

(Neisseria
gonorrhoeae) 		PF00923
(TAL_FSA) 		3 PRO A  44
ILE A 202
SER A 109
 None
 0.73A 5fsaA-3clmA:
undetectable		 5fsaA-3clmA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmg PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 PRO A 265
ILE A 281
SER A 205
 None
 0.73A 5fsaA-3cmgA:
undetectable		 5fsaA-3cmgA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvr INVASION PLASMID
ANTIGEN

(Shigella
flexneri) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		3 PRO A 179
ILE A 236
SER A 161
 None
 0.72A 5fsaA-3cvrA:
0.3		 5fsaA-3cvrA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM

(Homo sapiens) 		no annotation 3 PRO B 236
ILE B  99
SER B 296
 None
 0.79A 5fsaA-3dw8B:
undetectable		 5fsaA-3dw8B:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb8 CYSTEINE
PROTEASE-LIKE VIRA

(Shigella
flexneri) 		PF06872
(EspG) 		3 PRO A 125
ILE A 321
SER A  64
 None
 0.63A 5fsaA-3eb8A:
undetectable		 5fsaA-3eb8A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee1 EFFECTOR PROTEIN
VIRA

(Shigella
flexneri) 		PF06872
(EspG) 		3 PRO A 125
ILE A 321
SER A  64
 None
 0.79A 5fsaA-3ee1A:
undetectable		 5fsaA-3ee1A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ele AMINO TRANSFERASE

([Eubacterium]
rectale) 		PF00155
(Aminotran_1_2) 		3 PRO A  44
ILE A 358
SER A 246
 None
None
PLP  A 500 (-2.7A)
 0.74A 5fsaA-3eleA:
undetectable		 5fsaA-3eleA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE

(Mus musculus) 		PF00288
(GHMP_kinases_N) 		3 PRO A 379
ILE A  56
SER A 162
 None
 0.81A 5fsaA-3f0nA:
0.6		 5fsaA-3f0nA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo8 TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF17481
(Phage_sheath_1N) 		3 PRO D 253
ILE D 171
SER D 335
 None
 0.78A 5fsaA-3fo8D:
undetectable		 5fsaA-3fo8D:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0t PUTATIVE
AMINOTRANSFERASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		3 PRO A  78
ILE A  66
SER A 308
 None
 0.74A 5fsaA-3g0tA:
undetectable		 5fsaA-3g0tA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		3 PRO A  58
ILE A  84
SER A 100
 None
NIL  A   1 (-4.4A)
None
 0.67A 5fsaA-3gp0A:
undetectable		 5fsaA-3gp0A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqc DNA REPAIR PROTEIN
REV1

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		3 PRO A 463
ILE A 720
SER A 501
 None
 0.79A 5fsaA-3gqcA:
undetectable		 5fsaA-3gqcA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4y PUTATIVE CHEMOTAXIS
PROTEIN

(Desulfovibrio
vulgaris) 		PF13690
(CheX) 		3 PRO A  33
ILE A  49
SER A   2
 None
 0.70A 5fsaA-3h4yA:
undetectable		 5fsaA-3h4yA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF02738
(Ald_Xan_dh_C2) 		3 PRO B 297
ILE B 259
SER B  10
 None
 0.60A 5fsaA-3hrdB:
undetectable		 5fsaA-3hrdB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k55 BETA-HEMOLYSIN

(Staphylococcus
aureus) 		PF03372
(Exo_endo_phos) 		3 PRO A  76
ILE A 191
SER A  83
 None
 0.71A 5fsaA-3k55A:
undetectable		 5fsaA-3k55A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2o F-BOX ONLY PROTEIN 4

(Homo sapiens) 		PF00646
(F-box) 		3 PRO B 205
ILE B 214
SER B 199
 None
 0.77A 5fsaA-3l2oB:
undetectable		 5fsaA-3l2oB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2o F-BOX ONLY PROTEIN 4

(Homo sapiens) 		PF00646
(F-box) 		3 PRO B 205
ILE B 217
SER B 200
 None
 0.73A 5fsaA-3l2oB:
undetectable		 5fsaA-3l2oB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		3 PRO A 725
ILE A 784
SER A 694
 None
PEG  A7001 (-4.5A)
None
 0.74A 5fsaA-3lppA:
undetectable		 5fsaA-3lppA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3miz PUTATIVE
TRANSCRIPTIONAL
REGULATOR PROTEIN,
LACI FAMILY

(Rhizobium etli) 		PF13377
(Peripla_BP_3) 		3 PRO A 298
ILE A  93
SER A 327
 None
 0.78A 5fsaA-3mizA:
undetectable		 5fsaA-3mizA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 PRO B  59
ILE A  99
SER A  16
 None
 0.77A 5fsaA-3mm5B:
undetectable		 5fsaA-3mm5B:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o81 BETA-2-MICROGLOBULIN

(Gallus gallus) 		PF07654
(C1-set) 		3 PRO A  72
ILE A  37
SER A  16
 None
 0.73A 5fsaA-3o81A:
undetectable		 5fsaA-3o81A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5n RIBOFLAVIN UPTAKE
PROTEIN

(Staphylococcus
aureus) 		PF12822
(ECF_trnsprt) 		3 PRO A  50
ILE A  35
SER A  22
 None
 0.78A 5fsaA-3p5nA:
1.4		 5fsaA-3p5nA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5n RIBOFLAVIN UPTAKE
PROTEIN

(Staphylococcus
aureus) 		PF12822
(ECF_trnsprt) 		3 PRO A  50
ILE A 166
SER A  22
 None
 0.61A 5fsaA-3p5nA:
1.4		 5fsaA-3p5nA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE

(Francisella
tularensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 PRO A 281
ILE A 347
SER A 187
 None
 0.58A 5fsaA-3qtyA:
undetectable		 5fsaA-3qtyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r31 BETAINE ALDEHYDE
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF00171
(Aldedh) 		3 PRO A  13
ILE A 106
SER A  16
 None
 0.75A 5fsaA-3r31A:
undetectable		 5fsaA-3r31A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsc PUTATIVE
OXIDOREDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		3 PRO A 165
ILE A 155
SER A 227
 None
NAD  A 274 (-4.6A)
None
 0.79A 5fsaA-3tscA:
undetectable		 5fsaA-3tscA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3x OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 PRO A 153
ILE A  39
SER A 313
 None
 0.68A 5fsaA-3u3xA:
undetectable		 5fsaA-3u3xA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4y UNCHARACTERIZED
PROTEIN

(Desulfotomaculum
acetoxidans) 		PF10282
(Lactonase) 		3 PRO A 182
ILE A 142
SER A 226
 None
 0.74A 5fsaA-3u4yA:
undetectable		 5fsaA-3u4yA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uss PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF05995
(CDO_I) 		3 PRO A 117
ILE A 138
SER A 172
 None
 0.30A 5fsaA-3ussA:
undetectable		 5fsaA-3ussA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnk XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

([Clostridium]
cellulolyticum) 		PF01261
(AP_endonuc_2) 		3 PRO A  68
ILE A  32
SER A 110
 None
 0.75A 5fsaA-3vnkA:
undetectable		 5fsaA-3vnkA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo) 		PF00082
(Peptidase_S8) 		3 PRO A 490
ILE A 550
SER A 477
 None
 0.80A 5fsaA-3vtaA:
undetectable		 5fsaA-3vtaA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A

(Schizosaccharomyces
pombe) 		PF08662
(eIF2A) 		3 PRO A 319
ILE A 285
SER A 362
 None
 0.56A 5fsaA-3wj9A:
undetectable		 5fsaA-3wj9A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CMR4
CRISPR SYSTEM CMR
SUBUNIT CMR5

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs)
PF09701
(Cas_Cmr5) 		3 PRO C 134
ILE F   6
SER C 287
 None
 0.73A 5fsaA-3x1lC:
undetectable		 5fsaA-3x1lC:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		3 PRO A 603
ILE A 609
SER A 481
 None
 0.73A 5fsaA-3zzuA:
undetectable		 5fsaA-3zzuA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0t PUP--PROTEIN LIGASE

(Corynebacterium
glutamicum) 		PF03136
(Pup_ligase) 		3 PRO A 210
ILE A 203
SER A 214
 None
 0.76A 5fsaA-4b0tA:
undetectable		 5fsaA-4b0tA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boo ACETYLCHOLINE
RECEPTOR BETA
SUBUNIT

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		3 PRO B 464
ILE B 130
SER B 459
 None
 0.80A 5fsaA-4booB:
2.3		 5fsaA-4booB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cbx ACTIN-2

(Plasmodium
berghei) 		PF00022
(Actin) 		3 PRO A 102
ILE A 136
SER A   5
 None
 0.81A 5fsaA-4cbxA:
undetectable		 5fsaA-4cbxA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccw CARBOXYL ESTERASE NP

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		3 PRO A 214
ILE A 247
SER A 102
 None
 0.63A 5fsaA-4ccwA:
undetectable		 5fsaA-4ccwA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cit VANADIUM-DEPENDENT
HALOPEROXIDASE

(Zobellia
galactanivorans) 		PF01569
(PAP2) 		3 PRO A 262
ILE A 254
SER A  50
 OCS  A 260 ( 4.9A)
None
None
 0.80A 5fsaA-4citA:
undetectable		 5fsaA-4citA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0c BETA-2-MICROGLOBULIN

(Gallus gallus) 		PF07654
(C1-set) 		3 PRO B  71
ILE B  36
SER B  15
 None
 0.65A 5fsaA-4d0cB:
undetectable		 5fsaA-4d0cB:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0k A-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Chaetomium
thermophilum) 		no annotation 3 PRO A 248
ILE A 160
SER A 293
 None
 0.73A 5fsaA-4d0kA:
undetectable		 5fsaA-4d0kA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		no annotation 3 PRO A 422
ILE A 786
SER A 651
 None
 0.71A 5fsaA-4ecoA:
undetectable		 5fsaA-4ecoA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG

(Sphingomonas
paucimobilis) 		PF13417
(GST_N_3)
PF16865
(GST_C_5) 		3 PRO A 227
ILE A 121
SER A 233
 None
 0.77A 5fsaA-4g10A:
undetectable		 5fsaA-4g10A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP2
CAPSID PROTEIN VP3

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 PRO C 134
ILE C 105
SER B 216
 None
 0.81A 5fsaA-4gh4C:
undetectable		 5fsaA-4gh4C:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		3 PRO M 107
ILE M 127
SER M  33
 None
 0.79A 5fsaA-4gq2M:
0.9		 5fsaA-4gq2M:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Acinetobacter
sp. ADP1) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		3 PRO A 272
ILE A 343
SER A 253
 None
 0.61A 5fsaA-4gtnA:
undetectable		 5fsaA-4gtnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0n DNMT2

(Spodoptera
frugiperda) 		PF00145
(DNA_methylase) 		3 PRO A 302
ILE A 197
SER A  40
 None
 0.81A 5fsaA-4h0nA:
undetectable		 5fsaA-4h0nA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn3 LMO1757 PROTEIN

(Listeria
monocytogenes) 		PF07537
(CamS) 		3 PRO A  93
ILE A 220
SER A  48
 None
 0.70A 5fsaA-4hn3A:
undetectable		 5fsaA-4hn3A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME

(Rickettsia
typhi) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 PRO A 110
ILE A 116
SER A 106
 None
 0.41A 5fsaA-4hvtA:
undetectable		 5fsaA-4hvtA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		3 PRO A 136
ILE A  82
SER A 328
 None
 0.79A 5fsaA-4issA:
undetectable		 5fsaA-4issA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2

(Homo sapiens) 		PF00400
(WD40) 		3 PRO A 156
ILE A 462
SER A 208
 None
 0.79A 5fsaA-4j0wA:
undetectable		 5fsaA-4j0wA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0x RIBOSOMAL
RNA-PROCESSING
PROTEIN 9

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 PRO A 246
ILE A 524
SER A 292
 None
 0.78A 5fsaA-4j0xA:
undetectable		 5fsaA-4j0xA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le5 S-ADENOSYLMETHIONINE
SYNTHETASE

(Campylobacter
jejuni) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 PRO A 319
ILE A 269
SER A 347
 None
 0.66A 5fsaA-4le5A:
undetectable		 5fsaA-4le5A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II

(Acidothermus
cellulolyticus) 		no annotation 3 PRO A 423
ILE A 327
SER A 359
 None
 0.70A 5fsaA-4lgnA:
undetectable		 5fsaA-4lgnA:
20.39