SIMILAR PATTERNS OF AMINO ACIDS FOR 5FQD_E_LVYE1438_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amx COLLAGEN ADHESIN

(Staphylococcus
aureus) 		PF05737
(Collagen_bind) 		5 ASN A 273
HIS A 230
SER A 199
PHE A 173
GLY A 268
 None
 1.45A 5fqdE-1amxA:
0.0
5fqdF-1amxA:
0.0		 5fqdE-1amxA:
16.36
5fqdF-1amxA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfx PROTEIN (PH 2.5 ACID
PHOSPHATASE)

(Aspergillus
niger) 		PF00328
(His_Phos_2) 		5 HIS A  29
SER A 267
PHE A 216
ILE A 351
GLY A  31
 None
 1.48A 5fqdE-1qfxA:
0.0
5fqdF-1qfxA:
0.0		 5fqdE-1qfxA:
21.85
5fqdF-1qfxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 PRO A 171
HIS A 290
SER A 177
TRP A 180
PHE A 218
 None
 1.40A 5fqdE-2a3kA:
undetectable
5fqdF-2a3kA:
0.0		 5fqdE-2a3kA:
21.99
5fqdF-2a3kA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B

(Bacillus
subtilis) 		PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB) 		5 GLU A 531
SER A 533
PHE A 527
ILE A 401
GLY A 397
 None
 1.12A 5fqdE-2d7dA:
0.0
5fqdF-2d7dA:
0.0		 5fqdE-2d7dA:
21.26
5fqdF-2d7dA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6l CHITINASE

(Clonostachys
rosea) 		PF00704
(Glyco_hydro_18) 		5 ASN A  43
HIS A 404
SER A 403
ILE A 290
GLY A 377
 None
 1.26A 5fqdE-3g6lA:
0.0
5fqdF-3g6lA:
0.0		 5fqdE-3g6lA:
21.61
5fqdF-3g6lA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN

(Oleispira
antarctica) 		PF13419
(HAD_2) 		5 PRO A  54
HIS A  62
SER A  60
ILE A  72
GLY A  68
 None
 1.47A 5fqdE-3iruA:
0.0
5fqdF-3iruA:
0.0		 5fqdE-3iruA:
18.52
5fqdF-3iruA:
21.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		9 ASN B 353
PRO B 354
HIS B 355
HIS B 380
SER B 381
TRP B 382
TRP B 388
TRP B 402
PHE B 404
 LVY  B1429 (-4.1A)
LVY  B1429 (-4.7A)
LVY  B1429 (-4.5A)
LVY  B1429 (-4.0A)
LVY  B1429 (-3.8A)
LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
LVY  B1429 (-4.5A)
 0.34A 5fqdE-4ci2B:
51.1
5fqdF-4ci2B:
0.0		 5fqdE-4ci2B:
79.32
5fqdF-4ci2B:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		7 GLU B 379
HIS B 380
SER B 381
TRP B 382
TRP B 388
TRP B 402
PHE B 404
 None
LVY  B1429 (-4.0A)
LVY  B1429 (-3.8A)
LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
LVY  B1429 (-4.5A)
 0.83A 5fqdE-4ci2B:
51.1
5fqdF-4ci2B:
0.0		 5fqdE-4ci2B:
79.32
5fqdF-4ci2B:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tzc PROTEIN CEREBLON

(Mus musculus) 		no annotation 5 SER C 381
TRP C 382
TRP C 388
TRP C 402
PHE C 404
 EF2  C 502 (-4.1A)
EF2  C 502 ( 3.2A)
EF2  C 502 (-3.5A)
EF2  C 502 (-3.8A)
EF2  C 502 (-4.5A)
 0.21A 5fqdE-4tzcC:
17.1
5fqdF-4tzcC:
2.2		 5fqdE-4tzcC:
33.02
5fqdF-4tzcC:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v30 CEREBLON ISOFORM 4

(Magnetospirillum
gryphiswaldense) 		no annotation 6 ASN A  50
PRO A  51
SER A  78
TRP A  79
TRP A  85
TRP A  99
 LVY  A 151 (-3.8A)
LVY  A 151 (-4.4A)
LVY  A 151 (-4.0A)
LVY  A 151 (-3.2A)
LVY  A 151 (-3.4A)
LVY  A 151 (-3.7A)
 0.44A 5fqdE-4v30A:
18.6
5fqdF-4v30A:
0.0		 5fqdE-4v30A:
16.14
5fqdF-4v30A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v30 CEREBLON ISOFORM 4

(Magnetospirillum
gryphiswaldense) 		no annotation 5 GLU A  76
SER A  78
TRP A  79
TRP A  85
TRP A  99
 None
LVY  A 151 (-4.0A)
LVY  A 151 (-3.2A)
LVY  A 151 (-3.4A)
LVY  A 151 (-3.7A)
 1.02A 5fqdE-4v30A:
18.6
5fqdF-4v30A:
0.0		 5fqdE-4v30A:
16.14
5fqdF-4v30A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 SER A 369
TRP A 359
TRP A  68
ILE A 710
GLY A  67
 None
None
None
EDO  A1870 (-4.1A)
None
 1.34A 5fqdE-5fjiA:
undetectable
5fqdF-5fjiA:
undetectable		 5fqdE-5fjiA:
18.15
5fqdF-5fjiA:
17.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON

(Homo sapiens) 		no annotation 10 ASN Z 351
PRO Z 352
HIS Z 353
GLU Z 377
HIS Z 378
SER Z 379
TRP Z 380
TRP Z 386
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
None
85C  Z 502 (-3.7A)
 0.59A 5fqdE-5hxbZ:
51.4
5fqdF-5hxbZ:
undetectable		 5fqdE-5hxbZ:
99.26
5fqdF-5hxbZ:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON

(Homo sapiens) 		no annotation 10 ASN Z 351
PRO Z 352
HIS Z 353
HIS Z 378
SER Z 379
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
85C  Z 502 (-3.7A)
 0.39A 5fqdE-5hxbZ:
51.4
5fqdF-5hxbZ:
undetectable		 5fqdE-5hxbZ:
99.26
5fqdF-5hxbZ:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 5 ASN Z 351
PRO Z 352
HIS Z 378
SER Z 379
PHE Z 381
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
None
 1.25A 5fqdE-5hxbZ:
51.4
5fqdF-5hxbZ:
undetectable		 5fqdE-5hxbZ:
99.26
5fqdF-5hxbZ:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		5 ASN A 115
HIS A 117
SER A 183
PHE A  86
ILE A 139
 None
 1.43A 5fqdE-5kcaA:
undetectable
5fqdF-5kcaA:
undetectable		 5fqdE-5kcaA:
18.16
5fqdF-5kcaA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yly NITRATE REDUCTASE

(Ulva prolifera) 		no annotation 5 ASN A 726
HIS A 727
GLU A 862
SER A 832
GLY A 857
 None
 1.37A 5fqdE-5ylyA:
undetectable
5fqdF-5ylyA:
0.6		 5fqdE-5ylyA:
11.78
5fqdF-5ylyA:
12.02