SIMILAR PATTERNS OF AMINO ACIDS FOR 5FQD_B_LVYB1438_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		8 ASN B 353
PRO B 354
HIS B 355
HIS B 380
TRP B 382
TRP B 388
TRP B 402
PHE B 404
 LVY  B1429 (-4.1A)
LVY  B1429 (-4.7A)
LVY  B1429 (-4.5A)
LVY  B1429 (-4.0A)
LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
LVY  B1429 (-4.5A)
 0.36A 5fqdB-4ci2B:
53.5
5fqdC-4ci2B:
0.0		 5fqdB-4ci2B:
79.32
5fqdC-4ci2B:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		6 GLU B 379
HIS B 380
TRP B 382
TRP B 388
TRP B 402
PHE B 404
 None
LVY  B1429 (-4.0A)
LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
LVY  B1429 (-4.5A)
 0.87A 5fqdB-4ci2B:
53.5
5fqdC-4ci2B:
0.0		 5fqdB-4ci2B:
79.32
5fqdC-4ci2B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v30 CEREBLON ISOFORM 4

(Magnetospirillum
gryphiswaldense) 		no annotation 5 ASN A  50
PRO A  51
TRP A  79
TRP A  85
TRP A  99
 LVY  A 151 (-3.8A)
LVY  A 151 (-4.4A)
LVY  A 151 (-3.2A)
LVY  A 151 (-3.4A)
LVY  A 151 (-3.7A)
 0.48A 5fqdB-4v30A:
0.0
5fqdC-4v30A:
0.0		 5fqdB-4v30A:
16.14
5fqdC-4v30A:
13.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON

(Homo sapiens) 		no annotation 9 ASN Z 351
PRO Z 352
HIS Z 353
GLU Z 377
HIS Z 378
TRP Z 380
TRP Z 386
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
None
85C  Z 502 (-3.7A)
 0.58A 5fqdB-5hxbZ:
53.2
5fqdC-5hxbZ:
0.0		 5fqdB-5hxbZ:
99.26
5fqdC-5hxbZ:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON

(Homo sapiens) 		no annotation 9 ASN Z 351
PRO Z 352
HIS Z 353
HIS Z 378
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
85C  Z 502 (-3.7A)
 0.35A 5fqdB-5hxbZ:
53.2
5fqdC-5hxbZ:
0.0		 5fqdB-5hxbZ:
99.26
5fqdC-5hxbZ:
21.51