SIMILAR PATTERNS OF AMINO ACIDS FOR 5FPD_B_PZAB1385_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aoh CELLULOSOMAL-SCAFFOL
DING PROTEIN A

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		4 ASN A 114
VAL A 146
ALA A  15
GLY A  18
 None
 0.90A 5fpdB-1aohA:
undetectable		 5fpdB-1aohA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aow ANNEXIN IV

(Bos taurus) 		PF00191
(Annexin) 		4 VAL A 152
SER A 153
ALA A 156
ARG A 140
 None
 0.92A 5fpdB-1aowA:
undetectable		 5fpdB-1aowA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8x PROTEIN (AML-1B)

(Escherichia
coli) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 VAL A 105
SER A 106
ALA A 109
GLY A 204
 None
 0.91A 5fpdB-1b8xA:
0.0		 5fpdB-1b8xA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8x PROTEIN (AML-1B)

(Escherichia
coli) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 VAL A 105
SER A 106
ALA A 109
GLY A 210
 None
 0.85A 5fpdB-1b8xA:
0.0		 5fpdB-1b8xA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bd8 P19INK4D CDK4/6
INHIBITOR

(Homo sapiens) 		PF12796
(Ank_2) 		4 VAL A 123
SER A 124
ALA A 127
GLY A 160
 None
 0.86A 5fpdB-1bd8A:
undetectable		 5fpdB-1bd8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 ASN A 354
VAL A 357
ALA A 361
ARG A 414
 None
 0.87A 5fpdB-1bf2A:
0.2		 5fpdB-1bf2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg5 FUSION PROTEIN OF
ALPHA-NA,K-ATPASE
WITH GLUTATHIONE
S-TRANSFERASE

(Rattus
norvegicus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 VAL A 106
SER A 107
ALA A 110
GLY A 211
 None
 0.89A 5fpdB-1bg5A:
undetectable		 5fpdB-1bg5A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)

(Geobacillus
stearothermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 VAL A 322
SER A 321
ALA A 320
GLY A 318
VAL A 127
 None
 1.40A 5fpdB-1brwA:
2.2		 5fpdB-1brwA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cw5 TYPE IIA BACTERIOCIN
CARNOBACTERIOCIN B2

(Carnobacterium
maltaromaticum) 		PF01721
(Bacteriocin_II) 		4 ASN A  31
VAL A  34
SER A  35
ALA A  38
 None
 0.63A 5fpdB-1cw5A:
undetectable		 5fpdB-1cw5A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebl BETA-KETOACYL-ACP
SYNTHASE III

(Escherichia
coli) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 VAL A 121
SER A 120
GLY A 114
VAL A 108
 None
 0.84A 5fpdB-1eblA:
1.5		 5fpdB-1eblA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fu1 DNA REPAIR PROTEIN
XRCC4

(Homo sapiens) 		PF06632
(XRCC4) 		4 SER A  53
ALA A  56
GLY A  64
VAL A  67
 None
 0.83A 5fpdB-1fu1A:
undetectable		 5fpdB-1fu1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g43 SCAFFOLDING PROTEIN

([Clostridium]
cellulolyticum) 		PF00942
(CBM_3) 		4 ASN A  30
VAL A   6
ALA A 155
GLY A 151
 None
 0.82A 5fpdB-1g43A:
undetectable		 5fpdB-1g43A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
GLYCEROL DEHYDRATASE
GAMMA SUBUNIT

(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		PF02286
(Dehydratase_LU)
PF02287
(Dehydratase_SU) 		4 ASN G 120
SER A 248
ALA A 247
GLY A 292
 None
 0.88A 5fpdB-1iwpG:
undetectable		 5fpdB-1iwpG:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy8 LEVODIONE REDUCTASE

(Leifsonia
aquatica) 		PF13561
(adh_short_C2) 		4 VAL A 256
ALA A 194
GLY A 154
ARG A 177
 None
 0.76A 5fpdB-1iy8A:
2.0		 5fpdB-1iy8A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		4 ASN A 419
VAL A 400
ALA A 398
GLY A 363
 None
 0.89A 5fpdB-1k72A:
undetectable		 5fpdB-1k72A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		4 VAL A 493
ALA A 497
VAL A 558
ARG A 562
 None
 0.80A 5fpdB-1kehA:
undetectable		 5fpdB-1kehA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kho ALPHA-TOXIN

(Clostridium
perfringens) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		4 ASN A 182
SER A 187
GLY A 349
ARG A 238
 None
 0.87A 5fpdB-1khoA:
undetectable		 5fpdB-1khoA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kj9 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE 2

(Escherichia
coli) 		PF02222
(ATP-grasp) 		4 VAL A 312
ALA A 211
GLY A 262
VAL A 209
 None
 0.87A 5fpdB-1kj9A:
undetectable		 5fpdB-1kj9A:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE

(Methanothermobacter
thermautotrophicus) 		PF13847
(Methyltransf_31) 		4 ASN A  83
VAL A  58
ALA A  60
GLY A  45
 None
None
None
SAH  A 801 (-4.0A)
 0.90A 5fpdB-1l3iA:
undetectable		 5fpdB-1l3iA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lbu MURAMOYL-PENTAPEPTID
E CARBOXYPEPTIDASE

(Streptomyces
albus) 		PF01471
(PG_binding_1)
PF08291
(Peptidase_M15_3) 		4 ASN A 143
VAL A 146
GLY A 191
ARG A 138
 None
None
None
ZN  A 214 ( 4.6A)
 0.88A 5fpdB-1lbuA:
undetectable		 5fpdB-1lbuA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p99 HYPOTHETICAL PROTEIN
PG110

(Staphylococcus
aureus) 		PF03180
(Lipoprotein_9) 		4 VAL A 146
SER A 147
ALA A 150
GLY A 169
 None
 0.87A 5fpdB-1p99A:
undetectable		 5fpdB-1p99A:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqf PROTEIN (COMPLEMENT
C3DG)

(Rattus
norvegicus) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 VAL A1141
SER A1142
ALA A1145
GLY A1193
 None
 0.71A 5fpdB-1qqfA:
undetectable		 5fpdB-1qqfA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6e TYPEIII-SECRETED
PROTEIN EFFECTOR:
INVASION-ASSOCIATED
PROTEIN

(Salmonella
enterica) 		PF07487
(SopE_GEF) 		4 ASN A 192
VAL A 195
SER A 196
ALA A 199
 None
 0.86A 5fpdB-1r6eA:
2.1		 5fpdB-1r6eA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ASN A 356
VAL A 358
SER A 359
ALA A 362
 None
 0.84A 5fpdB-1r8wA:
2.6		 5fpdB-1r8wA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc2 AQUAPORIN Z

(Escherichia
coli) 		no annotation 4 ASN B 182
ALA B 201
VAL B 193
ARG B 189
 None
 0.88A 5fpdB-1rc2B:
undetectable		 5fpdB-1rc2B:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 VAL A 446
SER A 447
ALA A 449
GLY A 451
VAL A 453
 None
 1.39A 5fpdB-1tkcA:
2.9		 5fpdB-1tkcA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uiy ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		4 ASN A 102
VAL A 101
ALA A 113
GLY A 109
 None
 0.89A 5fpdB-1uiyA:
undetectable		 5fpdB-1uiyA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukm EMS16 B CHAIN

(Echis
multisquamatus) 		PF00059
(Lectin_C) 		4 VAL B  50
SER B  51
ALA B  54
VAL B 119
 None
 0.84A 5fpdB-1ukmB:
undetectable		 5fpdB-1ukmB:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		4 VAL A 236
ALA A 182
GLY A 143
ARG A 165
 None
 0.91A 5fpdB-1uznA:
undetectable		 5fpdB-1uznA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Pyrobaculum
aerophilum) 		PF01791
(DeoC) 		4 VAL A  73
SER A  74
ALA A  77
GLY A 113
 None
 0.76A 5fpdB-1vcvA:
1.9		 5fpdB-1vcvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu7 HISTIDYL-TRNA
SYNTHETASE

(Thermoplasma
acidophilum) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 VAL A 212
SER A 213
ALA A 216
VAL A 199
 None
 0.73A 5fpdB-1wu7A:
undetectable		 5fpdB-1wu7A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxx HYPOTHETICAL PROTEIN
TTHA1280

(Thermus
thermophilus) 		PF10672
(Methyltrans_SAM) 		4 ASN A 258
VAL A 234
ALA A 236
GLY A 221
 None
 0.85A 5fpdB-1wxxA:
undetectable		 5fpdB-1wxxA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		4 ASN A 235
VAL A 182
ALA A 158
GLY A 160
 None
 0.92A 5fpdB-1xrsA:
undetectable		 5fpdB-1xrsA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN

(Aspergillus
niger) 		PF01828
(Peptidase_A4) 		4 VAL B 168
SER B 167
ALA B 132
GLY B 142
 None
 0.83A 5fpdB-1y43B:
undetectable		 5fpdB-1y43B:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		4 SER A  28
ALA A  27
GLY A 361
ARG A 212
 SUG  A1001 (-2.7A)
None
SUG  A1001 ( 4.2A)
SUG  A1001 (-3.0A)
 0.90A 5fpdB-1yniA:
undetectable		 5fpdB-1yniA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2i MALATE DEHYDROGENASE

(Agrobacterium
tumefaciens) 		PF02615
(Ldh_2) 		4 VAL A 223
ALA A 209
VAL A 194
ARG A 198
 None
 0.86A 5fpdB-1z2iA:
undetectable		 5fpdB-1z2iA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adv GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE

(Pseudomonas sp.
SY-77-1) 		PF01804
(Penicil_amidase) 		4 VAL C 324
ALA C 328
VAL C 389
ARG C 393
 None
 0.81A 5fpdB-2advC:
undetectable		 5fpdB-2advC:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbz VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR

(Molluscum
contagiosum
virus) 		PF01335
(DED) 		4 VAL A 154
SER A 155
ALA A 158
VAL A 174
 None
 0.71A 5fpdB-2bbzA:
undetectable		 5fpdB-2bbzA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwg GMP REDUCTASE I

(Homo sapiens) 		PF00478
(IMPDH) 		4 VAL A 239
SER A 218
ALA A 236
GLY A 233
 None
 0.88A 5fpdB-2bwgA:
undetectable		 5fpdB-2bwgA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1y HYPOTHETICAL PROTEIN
TT0321

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		4 ALA A 178
GLY A 139
VAL A 157
ARG A 161
 None
 0.89A 5fpdB-2d1yA:
1.7		 5fpdB-2d1yA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 4 VAL A 105
ALA A 221
VAL A 240
ARG A 238
 None
 0.91A 5fpdB-2de2A:
undetectable		 5fpdB-2de2A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkp PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 5

(Homo sapiens) 		PF00169
(PH) 		4 VAL A  21
GLY A  25
VAL A  44
ARG A  15
 None
 0.91A 5fpdB-2dkpA:
undetectable		 5fpdB-2dkpA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE

(Pyrococcus
horikoshii) 		PF01177
(Asp_Glu_race) 		4 VAL A 104
SER A 105
ALA A 108
GLY A 116
 None
 0.68A 5fpdB-2eq5A:
2.5		 5fpdB-2eq5A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frw CYTOPLASMIC PROTEIN
NCK2

(Homo sapiens) 		PF14604
(SH3_9) 		4 ASN A  41
VAL A  25
GLY A  22
VAL A  20
 None
 0.93A 5fpdB-2frwA:
undetectable		 5fpdB-2frwA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gup ROK FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF00480
(ROK) 		4 ASN A 274
VAL A 104
GLY A 128
VAL A 122
 SUC  A 290 (-2.8A)
SUC  A 290 (-4.7A)
None
None
 0.80A 5fpdB-2gupA:
10.6		 5fpdB-2gupA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h92 CYTIDYLATE KINASE

(Staphylococcus
aureus) 		PF02224
(Cytidylate_kin) 		4 VAL A  95
SER A  96
ALA A  99
ARG A  39
 C5P  A1300 (-4.3A)
C5P  A1300 (-3.6A)
C5P  A1300 ( 3.7A)
C5P  A1300 (-4.0A)
 0.92A 5fpdB-2h92A:
undetectable		 5fpdB-2h92A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6g PUTATIVE
METHYLTRANSFERASE

(Salmonella
enterica) 		PF03848
(TehB) 		4 ASN A  79
VAL A  55
ALA A  57
GLY A  42
 EDO  A 205 (-3.4A)
None
None
EDO  A 200 ( 4.8A)
 0.86A 5fpdB-2i6gA:
undetectable		 5fpdB-2i6gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ij9 URIDYLATE KINASE

(Archaeoglobus
fulgidus) 		PF00696
(AA_kinase) 		4 ASN A 137
VAL A  11
SER A  10
GLY A  40
 None
None
None
SO4  A 301 (-3.4A)
 0.82A 5fpdB-2ij9A:
undetectable		 5fpdB-2ij9A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ij9 URIDYLATE KINASE

(Archaeoglobus
fulgidus) 		PF00696
(AA_kinase) 		4 ASN A 137
VAL A  11
SER A  10
GLY A  41
 None
None
None
SO4  A 301 (-4.3A)
 0.92A 5fpdB-2ij9A:
undetectable		 5fpdB-2ij9A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN

(Homo sapiens) 		PF01269
(Fibrillarin) 		4 ASN A 210
VAL A 188
ALA A 190
GLY A 172
 None
 0.64A 5fpdB-2ipxA:
1.7		 5fpdB-2ipxA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2miz M04 IMMUNOEVASIN

(Murid
betaherpesvirus
1) 		PF12216
(m04gp34like) 		4 VAL A  73
ALA A  90
GLY A 124
VAL A 114
 None
 0.88A 5fpdB-2mizA:
undetectable		 5fpdB-2mizA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nuu NITROGEN REGULATORY
PROTEIN P-II 2

(Escherichia
coli) 		PF00543
(P-II) 		4 VAL G  77
SER G  78
ALA G  81
GLY G  89
 None
None
None
ADP  G1400 (-3.9A)
 0.71A 5fpdB-2nuuG:
undetectable		 5fpdB-2nuuG:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nuu NITROGEN REGULATORY
PROTEIN P-II 2

(Escherichia
coli) 		PF00543
(P-II) 		4 VAL G  77
SER G  78
ALA G  81
VAL G   6
 None
 0.88A 5fpdB-2nuuG:
undetectable		 5fpdB-2nuuG:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owz FRUCTOSE-1,6-BISPHOS
PHATASE

(Escherichia
coli) 		PF00316
(FBPase) 		5 ASN A  70
SER A  88
ALA A  87
GLY A  85
VAL A  95
 None
 1.39A 5fpdB-2owzA:
undetectable		 5fpdB-2owzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 272
SER A 273
ALA A 103
GLY A  48
 None
 0.86A 5fpdB-2pceA:
undetectable		 5fpdB-2pceA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 4 VAL A 207
SER A 208
ALA A 211
GLY A 233
 None
 0.89A 5fpdB-2po4A:
undetectable		 5fpdB-2po4A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prx THIOESTERASE
SUPERFAMILY PROTEIN

(Shewanella
loihica) 		PF03061
(4HBT) 		4 VAL A 127
ALA A 147
GLY A  69
VAL A 129
 None
 0.91A 5fpdB-2prxA:
undetectable		 5fpdB-2prxA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		4 VAL A 368
ALA A 455
GLY A 214
VAL A 218
 None
 0.87A 5fpdB-2qveA:
undetectable		 5fpdB-2qveA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb9 HYPE PROTEIN

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ASN A 228
VAL A 231
ALA A 235
GLY A 311
 None
 0.72A 5fpdB-2rb9A:
undetectable		 5fpdB-2rb9A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		4 ASN A 192
VAL A 182
SER A 181
ALA A 180
 NLG  A2001 (-2.8A)
None
NLG  A2001 ( 4.2A)
None
 0.81A 5fpdB-2rd5A:
undetectable		 5fpdB-2rd5A:
23.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2v7z HEAT SHOCK COGNATE
71 KDA PROTEIN

(Rattus
norvegicus) 		PF00012
(HSP70) 		4 ASN A 235
VAL A 238
VAL A 260
ARG A 264
 None
 0.92A 5fpdB-2v7zA:
56.4		 5fpdB-2v7zA:
89.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2was 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Saccharomyces
cerevisiae) 		PF01648
(ACPS) 		4 VAL B1869
SER B1870
ALA B1880
GLY B1811
 None
 0.91A 5fpdB-2wasB:
undetectable		 5fpdB-2wasB:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3h K5 LYASE

(Escherichia
virus K1-5) 		no annotation 4 VAL A 246
ALA A 248
GLY A 283
VAL A 256
 None
 0.92A 5fpdB-2x3hA:
undetectable		 5fpdB-2x3hA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xq1 PEROXISOMAL CATALASE

(Ogataea angusta) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ASN A 234
VAL A 232
ALA A 228
GLY A 204
 None
 0.93A 5fpdB-2xq1A:
undetectable		 5fpdB-2xq1A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xva TELLURITE RESISTANCE
PROTEIN TEHB

(Escherichia
coli) 		PF03848
(TehB) 		4 ASN A  79
VAL A  55
ALA A  57
GLY A  42
 None
 0.86A 5fpdB-2xvaA:
undetectable		 5fpdB-2xvaA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 VAL A 140
SER A 141
GLY A 759
VAL A 761
 None
 0.89A 5fpdB-2y8nA:
undetectable		 5fpdB-2y8nA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		4 VAL A  90
ALA A  66
GLY A  49
ARG A  78
 None
 0.89A 5fpdB-2yr0A:
undetectable		 5fpdB-2yr0A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0r PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0547

(Thermus
thermophilus) 		PF11572
(DUF3234) 		4 VAL A  77
SER A  30
GLY A  70
VAL A  93
 None
 0.84A 5fpdB-2z0rA:
undetectable		 5fpdB-2z0rA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		4 VAL A 236
SER A 279
ALA A 282
GLY A 287
 None
 0.91A 5fpdB-3a1nA:
2.2		 5fpdB-3a1nA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a27 UNCHARACTERIZED
PROTEIN MJ1557

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		4 ASN A 147
VAL A 123
ALA A 125
GLY A 108
 None
 0.69A 5fpdB-3a27A:
undetectable		 5fpdB-3a27A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE

(Neospora
caninum) 		PF01150
(GDA1_CD39) 		4 ASN A 439
SER A 444
ALA A 443
GLY A 213
 None
 0.88A 5fpdB-3agrA:
4.7		 5fpdB-3agrA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akf PUTATIVE SECRETED
ALPHA
L-ARABINOFURANOSIDAS
E II

(Streptomyces
avermitilis) 		PF04616
(Glyco_hydro_43)
PF05270
(AbfB) 		4 VAL A  37
ALA A  35
VAL A  44
ARG A  42
 None
 0.90A 5fpdB-3akfA:
undetectable		 5fpdB-3akfA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt7 TRNA
(URACIL-5-)-METHYLTR
ANSFERASE

(Escherichia
coli) 		PF05958
(tRNA_U5-meth_tr) 		4 ASN A 259
VAL A 235
ALA A 237
GLY A 222
 None
 0.79A 5fpdB-3bt7A:
undetectable		 5fpdB-3bt7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdx SUCCINYLGLUTAMATEDES
UCCINYLASE/ASPARTOAC
YLASE

(Rhodobacter
sphaeroides) 		PF04952
(AstE_AspA) 		4 ASN A 161
SER A 159
ALA A 183
GLY A 228
 None
 0.82A 5fpdB-3cdxA:
undetectable		 5fpdB-3cdxA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdx SUCCINYLGLUTAMATEDES
UCCINYLASE/ASPARTOAC
YLASE

(Rhodobacter
sphaeroides) 		PF04952
(AstE_AspA) 		4 VAL A 332
ALA A 321
GLY A 324
VAL A 326
 None
 0.93A 5fpdB-3cdxA:
undetectable		 5fpdB-3cdxA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME

(Schistosoma
japonicum) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 VAL A 106
SER A 107
ALA A 110
GLY A 211
 None
 0.49A 5fpdB-3cruA:
undetectable		 5fpdB-3cruA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfg REGULATORY PROTEIN
RECX

(Xanthomonas
campestris) 		PF02631
(RecX) 		5 ASN A  76
VAL A  73
SER A  72
ALA A  70
ARG A  77
 None
 1.46A 5fpdB-3dfgA:
undetectable		 5fpdB-3dfgA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh0 SAM DEPENDENT
METHYLTRANSFERASE

(Aquifex
aeolicus) 		PF13847
(Methyltransf_31) 		4 ASN A  89
VAL A  65
ALA A  67
GLY A  49
 None
 0.81A 5fpdB-3dh0A:
undetectable		 5fpdB-3dh0A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		5 SER A 424
ALA A 423
GLY A  59
VAL A  57
ARG A 259
 None
 1.46A 5fpdB-3du4A:
undetectable		 5fpdB-3du4A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewo NON-STRUCTURAL
PROTEIN 3

(Avian
coronavirus) 		PF01661
(Macro) 		5 ASN A  93
VAL A 116
SER A 115
ALA A 112
GLY A  97
 None
 1.42A 5fpdB-3ewoA:
undetectable		 5fpdB-3ewoA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpg NON-STRUCTURAL
PROTEIN 3

(Chikungunya
virus) 		PF01661
(Macro) 		5 VAL A 104
SER A 103
ALA A 137
GLY A 100
VAL A  96
 None
 1.33A 5fpdB-3gpgA:
undetectable		 5fpdB-3gpgA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1v GLUCOKINASE

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 VAL X 374
SER X 375
ALA X 378
GLY X 294
 None
 0.84A 5fpdB-3h1vX:
0.0		 5fpdB-3h1vX:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjg PUTATIVE
ALPHA-RIBAZOLE-5'-PH
OSPHATE PHOSPHATASE
COBC

(Vibrio
parahaemolyticus) 		PF00300
(His_Phos_1) 		4 ASN A 176
VAL A  14
ALA A  16
GLY A  19
 None
 0.89A 5fpdB-3hjgA:
undetectable		 5fpdB-3hjgA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 ASN A 276
VAL A 257
ALA A 215
GLY A 179
 None
 0.89A 5fpdB-3hjrA:
undetectable		 5fpdB-3hjrA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrx PROBABLE ENOYL-COA
HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		4 ASN A  99
VAL A  98
ALA A 110
GLY A 106
 None
 0.85A 5fpdB-3hrxA:
undetectable		 5fpdB-3hrxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		5 ASN A 209
VAL A 180
ALA A 237
GLY A 188
ARG A 196
 None
 1.34A 5fpdB-3hutA:
undetectable		 5fpdB-3hutA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxl UNCHARACTERIZED
PROTEIN DSY3957

(Desulfitobacterium
hafniense) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		4 ASN A 251
VAL A 294
ALA A 291
GLY A 287
 None
 0.91A 5fpdB-3hxlA:
undetectable		 5fpdB-3hxlA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A

(Doryteuthis
pealeii) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N) 		4 SER A 732
ALA A 735
GLY A 737
VAL A 740
 None
 0.88A 5fpdB-3i5gA:
undetectable		 5fpdB-3i5gA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kaq FLAVODOXIN

(Desulfovibrio
desulfuricans) 		PF00258
(Flavodoxin_1) 		4 VAL A 119
ALA A  89
GLY A 123
ARG A 113
 None
 0.90A 5fpdB-3kaqA:
2.1		 5fpdB-3kaqA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6n METALLO-BETA-LACTAMA
SE

(Chryseobacterium
indologenes) 		PF00753
(Lactamase_B) 		4 VAL A  92
ALA A  94
GLY A 103
VAL A  67
 None
 0.89A 5fpdB-3l6nA:
undetectable		 5fpdB-3l6nA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lby PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1697C

(Streptococcus
mutans) 		PF06962
(rRNA_methylase) 		4 ASN A  68
VAL A  44
ALA A  46
GLY A  31
 None
 0.88A 5fpdB-3lbyA:
2.0		 5fpdB-3lbyA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mud DNA REPAIR PROTEIN
XRCC4,TROPOMYOSIN
ALPHA-1 CHAIN

(Gallus gallus;
Homo sapiens) 		PF06632
(XRCC4) 		4 SER A  53
ALA A  56
GLY A  64
VAL A  67
 None
 0.69A 5fpdB-3mudA:
undetectable		 5fpdB-3mudA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		4 ASN A 340
ALA A 173
GLY A 146
VAL A 303
 None
 0.85A 5fpdB-3n0lA:
undetectable		 5fpdB-3n0lA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE

(Clostridioides
difficile) 		PF06050
(HGD-D) 		5 ASN B  16
VAL B  19
ALA B  30
GLY B  32
VAL B  51
 None
 1.16A 5fpdB-3o3mB:
undetectable		 5fpdB-3o3mB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus) 		PF13649
(Methyltransf_25) 		4 ASN A  91
VAL A  71
ALA A  73
GLY A  58
 None
 0.81A 5fpdB-3ou6A:
undetectable		 5fpdB-3ou6A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H

(Human
gammaherpesvirus
4) 		no annotation 4 ASN A 405
VAL A 639
SER A 636
GLY A 616
 None
 0.89A 5fpdB-3phfA:
undetectable		 5fpdB-3phfA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 ASN A 352
ALA A 268
GLY A 238
VAL A 270
 None
 0.90A 5fpdB-3pocA:
undetectable		 5fpdB-3pocA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzl AGMATINE
UREOHYDROLASE

(Thermoplasma
volcanium) 		PF00491
(Arginase) 		5 VAL A 292
SER A 296
ALA A 295
GLY A  76
ARG A 255
 None
 1.30A 5fpdB-3pzlA:
undetectable		 5fpdB-3pzlA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4f DNA REPAIR PROTEIN
XRCC4

(Homo sapiens) 		PF06632
(XRCC4) 		4 SER C  53
ALA C  56
GLY C  64
VAL C  67
 None
 0.69A 5fpdB-3q4fC:
undetectable		 5fpdB-3q4fC:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9j SEPTUM
SITE-DETERMINING
PROTEIN MIND

(Escherichia
coli) 		PF01656
(CbiA) 		4 SER A  19
ALA A  22
GLY A 236
VAL A 227
 None
 0.85A 5fpdB-3r9jA:
undetectable		 5fpdB-3r9jA:
22.90