SIMILAR PATTERNS OF AMINO ACIDS FOR 5FHZ_D_READ602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II

(Saccharomyces
cerevisiae) 		PF00150
(Cellulase) 		5 ILE A 408
GLU A 334
GLY A 333
ARG A 131
GLU A  51
 None
GOL  A1450 ( 4.1A)
None
None
None
 1.38A 5fhzD-1h4pA:
undetectable		 5fhzD-1h4pA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		5 ILE A  84
GLY A 176
ARG A 177
GLU A  89
LEU A 127
 None
 1.07A 5fhzD-1jvwA:
undetectable		 5fhzD-1jvwA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6y S-ADENOSYL-METHYLTRA
NSFERASE MRAW

(Thermotoga
maritima) 		PF01795
(Methyltransf_5) 		5 ILE A 239
GLY A 237
ARG A 293
CYH A  31
LEU A 232
 None
 1.48A 5fhzD-1m6yA:
2.9		 5fhzD-1m6yA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryt RUBRERYTHRIN

(Desulfovibrio
vulgaris) 		PF02915
(Rubrerythrin) 		5 ILE A 142
GLU A 144
GLY A 145
ARG A 146
GLU A 172
 None
 1.32A 5fhzD-1rytA:
undetectable		 5fhzD-1rytA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8w AMP NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1)
PF10423
(AMNp_N) 		5 ILE A 341
GLY A 413
MET A 302
GLU A 405
THR A 377
 None
 1.45A 5fhzD-1t8wA:
undetectable		 5fhzD-1t8wA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaq CYTOSINE DEAMINASE

(Saccharomyces
cerevisiae) 		PF00383
(dCMP_cyt_deam_1) 		5 ILE A  38
ARG A 105
CYH A  71
THR A  67
LEU A  84
 None
 1.47A 5fhzD-1uaqA:
undetectable		 5fhzD-1uaqA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7l 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT

(Pyrococcus
horikoshii) 		PF00694
(Aconitase_C) 		5 ILE A 144
GLU A 147
GLY A 148
ASN A  94
LEU A 151
 None
 1.30A 5fhzD-1v7lA:
undetectable		 5fhzD-1v7lA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vko INOSITOL-3-PHOSPHATE
SYNTHASE

(Caenorhabditis
elegans) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		5 ILE A 278
GLU A 280
ARG A 216
ASN A 286
GLU A 240
 None
 1.29A 5fhzD-1vkoA:
undetectable		 5fhzD-1vkoA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE

(Aeropyrum
pernix) 		PF00793
(DAHP_synth_1) 		5 GLU A 171
GLY A 142
ARG A 143
GLU A 108
LEU A 137
 None
None
None
PEP  A 302 ( 4.3A)
None
 1.48A 5fhzD-1vs1A:
undetectable		 5fhzD-1vs1A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w52 PANCREATIC LIPASE
RELATED PROTEIN 2

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 ILE X 125
GLU X 162
GLY X 127
ARG X 166
ASN X  36
 None
 1.26A 5fhzD-1w52X:
undetectable		 5fhzD-1w52X:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wnb PUTATIVE BETAINE
ALDEHYDE
DEHYDROGENASE

(Escherichia
coli) 		PF00171
(Aldedh) 		7 ASN A 149
MET A 154
TRP A 157
GLU A 246
CYH A 280
THR A 281
LEU A 438
 NAI  A1001 ( 3.9A)
None
None
NAI  A1001 (-3.4A)
NAI  A1001 (-2.5A)
None
None
 0.74A 5fhzD-1wnbA:
54.3		 5fhzD-1wnbA:
36.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1f SIGNAL-TRANSDUCING
ADAPTOR PROTEIN 1

(Homo sapiens) 		PF00169
(PH) 		5 GLU A 102
GLY A 101
ARG A 105
TRP A 104
GLU A  40
 None
 1.46A 5fhzD-1x1fA:
undetectable		 5fhzD-1x1fA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yav HYPOTHETICAL PROTEIN
BSU14130

(Bacillus
subtilis) 		no annotation 5 ILE A  72
GLU A  79
GLY A  74
ARG A  77
ASN A  66
 None
 1.24A 5fhzD-1yavA:
undetectable		 5fhzD-1yavA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb6 (S)-ACETONE-CYANOHYD
RIN LYASE

(Hevea
brasiliensis) 		PF00561
(Abhydrolase_1) 		5 GLU A 155
TRP A 128
CYH A  81
THR A  11
LEU A 148
 None
MNN  A 300 (-3.8A)
MNN  A 300 ( 3.7A)
MNN  A 300 (-2.6A)
MNN  A 300 (-4.3A)
 0.90A 5fhzD-1yb6A:
2.8		 5fhzD-1yb6A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2d N-ACETYLGALACTOSAMIN
E KINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 GLU A 185
GLY A 186
GLU A 338
CYH A 377
CYH A 371
 None
A2G  A 459 (-3.3A)
None
None
None
 1.50A 5fhzD-2a2dA:
undetectable		 5fhzD-2a2dA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ILE A 351
GLU A 352
GLY A 353
ARG A 367
GLU A 236
 None
 1.12A 5fhzD-2bvgA:
undetectable		 5fhzD-2bvgA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewo PUTATIVE AGMATINE
DEIMINASE

(Streptococcus
mutans) 		PF04371
(PAD_porph) 		5 ILE A 165
GLY A 163
ARG A  99
ASN A 186
THR A 155
 None
 1.02A 5fhzD-2ewoA:
2.8		 5fhzD-2ewoA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 ILE X 224
GLU X 307
GLY X 305
CYH X 201
LEU X 312
 None
 1.31A 5fhzD-2iv2X:
undetectable		 5fhzD-2iv2X:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oe1 THIOREDOXIN-3

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		5 ILE A  65
GLU A  68
ARG A  14
THR A   5
LEU A  16
 None
SO4  A1002 (-4.3A)
SO4  A1003 ( 4.4A)
None
None
 1.28A 5fhzD-2oe1A:
undetectable		 5fhzD-2oe1A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE

(Homo sapiens) 		no annotation 5 ILE B  72
GLY B  70
CYH B 100
CYH B  96
LEU B  67
 None
None
None
ZN  B 605 (-2.2A)
None
 1.12A 5fhzD-2pvcB:
undetectable		 5fhzD-2pvcB:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 ILE A  75
GLU A  74
ARG A  72
ASN A  55
LEU A  44
 None
FMT  A 605 ( 4.8A)
FMT  A 605 (-4.0A)
None
None
 1.39A 5fhzD-2qfqA:
undetectable		 5fhzD-2qfqA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 ILE A 465
GLY A 518
ARG A 488
TRP A 520
GLU A 118
 MGD  A1765 (-4.8A)
None
MGD  A1765 (-2.9A)
None
None
 1.34A 5fhzD-2vpwA:
undetectable		 5fhzD-2vpwA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00171
(Aldedh) 		6 GLY A 104
ASN A 159
TRP A 163
GLU A 257
CYH A 296
THR A 297
 ETE  A1524 (-3.5A)
None
ETE  A1524 (-3.9A)
None
None
ETE  A1524 ( 4.1A)
 1.21A 5fhzD-2vroA:
41.3		 5fhzD-2vroA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00171
(Aldedh) 		5 GLY A 105
ASN A 159
GLU A 257
CYH A 296
THR A 297
 None
None
None
None
ETE  A1524 ( 4.1A)
 1.18A 5fhzD-2vroA:
41.3		 5fhzD-2vroA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE

(Neisseria
meningitidis) 		PF00132
(Hexapep) 		5 ILE A 115
GLU A  92
GLY A  91
CYH A 107
THR A  86
 None
 1.40A 5fhzD-2wlcA:
undetectable		 5fhzD-2wlcA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ILE A 874
GLY A 731
ARG A 728
GLU A 816
LEU A 727
 None
 1.46A 5fhzD-2xyuA:
undetectable		 5fhzD-2xyuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens) 		PF03496
(ADPrib_exo_Tox) 		5 ILE A  17
GLU A  14
TRP A  19
THR A 177
LEU A 141
 None
 1.36A 5fhzD-3buzA:
undetectable		 5fhzD-3buzA:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iwk AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		5 ASN A 162
MET A 167
TRP A 170
GLU A 260
CYH A 294
 NAD  A 505 ( 4.8A)
None
None
None
NAD  A 505 (-3.0A)
 1.03A 5fhzD-3iwkA:
55.6		 5fhzD-3iwkA:
39.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtx AMINOTRANSFERASE

(Neisseria
meningitidis) 		PF00155
(Aminotran_1_2) 		5 ILE A  93
GLU A  92
GLY A 258
ARG A 233
CYH A 208
 None
None
None
GOL  A 398 (-3.3A)
LLP  A 244 ( 3.5A)
 1.36A 5fhzD-3jtxA:
undetectable		 5fhzD-3jtxA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kar KINESIN-LIKE PROTEIN
KAR3

(Saccharomyces
cerevisiae) 		PF00225
(Kinesin) 		5 ILE A 602
GLU A 521
MET A 484
CYH A 469
LEU A 627
 None
 1.17A 5fhzD-3karA:
undetectable		 5fhzD-3karA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ILE A 888
GLY A 745
ARG A 742
GLU A 830
LEU A 741
 None
None
SO4  A   1 (-3.3A)
None
None
 1.46A 5fhzD-3kulA:
undetectable		 5fhzD-3kulA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0l STEROIDOGENIC ACUTE
REGULATORY PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF01852
(START) 		5 ILE A 154
GLU A 142
ASN A 150
TRP A 147
LEU A 137
 None
 1.24A 5fhzD-3p0lA:
undetectable		 5fhzD-3p0lA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN

(Pyrococcus
abyssi) 		PF00152
(tRNA-synt_2) 		5 ILE A  58
GLU A  56
GLY A  55
ASN A  97
THR A  46
 None
 1.41A 5fhzD-3p8tA:
undetectable		 5fhzD-3p8tA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rks HYDROXYNITRILASE

(Manihot
esculenta) 		PF00561
(Abhydrolase_1) 		5 ARG A 129
TRP A 128
CYH A  81
THR A  11
LEU A 149
 None
 1.43A 5fhzD-3rksA:
2.9		 5fhzD-3rksA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmj 2-ISOPROPYLMALATE
SYNTHASE

(Neisseria
meningitidis) 		PF00682
(HMGL-like) 		5 GLU A 183
ARG A 187
TRP A 201
CYH A 142
LEU A 189
 None
 1.25A 5fhzD-3rmjA:
undetectable		 5fhzD-3rmjA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Hoeflea
phototrophica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLU A 317
GLY A 316
MET A 119
GLU A 311
LEU A 289
 None
 1.23A 5fhzD-3t8qA:
2.2		 5fhzD-3t8qA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Hoeflea
phototrophica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLU A 317
GLY A 316
MET A 119
GLU A 311
THR A 293
 None
 1.39A 5fhzD-3t8qA:
2.2		 5fhzD-3t8qA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbk RIG-I HELICASE
DOMAIN

(Mus musculus) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		5 GLY A 416
MET A 762
CYH A 264
THR A 410
LEU A 431
 None
 1.45A 5fhzD-3tbkA:
undetectable		 5fhzD-3tbkA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 ILE A 168
GLU A 170
ASN A 285
CYH A 284
LEU A  92
 None
 1.44A 5fhzD-3wfaA:
undetectable		 5fhzD-3wfaA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		5 ILE A 585
GLY A 575
ARG A 584
THR A  45
LEU A  15
 None
 1.41A 5fhzD-3zqjA:
undetectable		 5fhzD-3zqjA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2q RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		5 GLY A 417
MET A 762
CYH A 266
THR A 411
LEU A 432
 None
 1.47A 5fhzD-4a2qA:
undetectable		 5fhzD-4a2qA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2w RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		5 GLY A 417
MET A 762
CYH A 266
THR A 411
LEU A 432
 None
 1.42A 5fhzD-4a2wA:
undetectable		 5fhzD-4a2wA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		5 GLY A 415
MET A 761
CYH A 263
THR A 409
LEU A 430
 None
 1.47A 5fhzD-4ay2A:
undetectable		 5fhzD-4ay2A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 ILE A 706
GLU A 705
GLY A 704
THR A 756
LEU A 740
 None
 1.18A 5fhzD-4b9yA:
undetectable		 5fhzD-4b9yA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 MET A 682
GLU A 941
CYH A 659
CYH A 660
LEU A 663
 None
None
None
None
AGS  A1985 (-4.2A)
 1.42A 5fhzD-4crsA:
undetectable		 5fhzD-4crsA:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dal PUTATIVE ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		7 ASN A 149
MET A 154
TRP A 157
GLU A 246
CYH A 280
THR A 281
LEU A 438
 None
 0.60A 5fhzD-4dalA:
32.7		 5fhzD-4dalA:
35.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Synechococcus
elongatus) 		PF13561
(adh_short_C2) 		5 ILE A  24
GLU A  27
ARG A 224
ASN A  92
LEU A 226
 None
 1.45A 5fhzD-4dmmA:
5.4		 5fhzD-4dmmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewf BETA-LACTAMASE

(Sphaerobacter
thermophilus) 		PF13354
(Beta-lactamase2) 		5 GLY A 174
ARG A 175
GLU A 190
THR A 228
LEU A 172
 None
 1.35A 5fhzD-4ewfA:
undetectable		 5fhzD-4ewfA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij4 CHITINASE A

(Gemmabryum
coronatum) 		PF00182
(Glyco_hydro_19) 		5 ILE A 160
GLY A 158
CYH A 192
THR A 189
LEU A 203
 None
 1.25A 5fhzD-4ij4A:
undetectable		 5fhzD-4ij4A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ina SACCHAROPINE
DEHYDROGENASE

(Wolinella
succinogenes) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 ILE A  55
GLU A  54
GLY A  53
MET A  22
GLU A 337
 None
 1.22A 5fhzD-4inaA:
undetectable		 5fhzD-4inaA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN

(Chaetomium
thermophilum) 		PF00557
(Peptidase_M24) 		5 ILE A 138
GLU A 139
GLY A 140
THR A 149
LEU A 145
 None
 1.49A 5fhzD-4ipaA:
undetectable		 5fhzD-4ipaA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 ILE A 131
GLY A 165
ARG A 155
GLU A 327
LEU A 157
 None
 1.14A 5fhzD-4lbwA:
undetectable		 5fhzD-4lbwA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		5 ILE A 577
GLU A 576
MET A 794
GLU A 539
CYH A 729
 None
 1.48A 5fhzD-4lglA:
undetectable		 5fhzD-4lglA:
21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 GLY A 123
ASN A 168
MET A 173
TRP A 176
THR A 302
 None
MES  A 501 (-3.6A)
MES  A 501 ( 4.1A)
None
MES  A 501 (-3.0A)
 0.74A 5fhzD-4lihA:
56.0		 5fhzD-4lihA:
39.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 GLY A 123
MET A 173
TRP A 176
GLU A 266
THR A 302
 None
MES  A 501 ( 4.1A)
None
None
MES  A 501 (-3.0A)
 1.23A 5fhzD-4lihA:
56.0		 5fhzD-4lihA:
39.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2j AMINOTRANSFERASE

(Streptomyces
lavendulae) 		PF00155
(Aminotran_1_2) 		5 ILE A 143
GLU A 142
GLY A 141
ASN A 162
LEU A 177
 None
None
None
PLP  A 401 ( 3.7A)
None
 0.94A 5fhzD-4m2jA:
2.5		 5fhzD-4m2jA:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o5h PHENYLACETALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 ASN A 177
MET A 182
TRP A 185
CYH A 309
THR A 310
 None
 0.92A 5fhzD-4o5hA:
54.5		 5fhzD-4o5hA:
44.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 GLY A 415
MET A 761
CYH A 263
THR A 409
LEU A 430
 None
 1.45A 5fhzD-4on9A:
undetectable		 5fhzD-4on9A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio cholerae) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 ILE F 223
ARG F 289
CYH F 135
CYH F 258
LEU F 226
 None
 1.32A 5fhzD-4p6vF:
5.7		 5fhzD-4p6vF:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qyj ALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 ASN A 169
MET A 174
TRP A 177
CYH A 301
THR A 302
 None
 0.72A 5fhzD-4qyjA:
53.8		 5fhzD-4qyjA:
42.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN

(Lactococcus
phage 1358) 		no annotation 5 ILE A 247
GLU A 249
GLY A 251
ARG A 378
CYH A 286
 None
 1.45A 5fhzD-4rggA:
undetectable		 5fhzD-4rggA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9u NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio cholerae) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 ILE A 223
ARG A 289
CYH A 135
CYH A 258
LEU A 226
 None
 1.36A 5fhzD-4u9uA:
5.4		 5fhzD-4u9uA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uir OLEATE HYDRATASE

(Elizabethkingia
meningoseptica) 		PF06100
(MCRA) 		5 ILE A 489
GLU A 490
CYH A 396
THR A 500
LEU A 480
 None
 1.46A 5fhzD-4uirA:
2.3		 5fhzD-4uirA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8b EXO-XYLOGLUCANASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		5 GLU A 431
ARG A 193
TRP A 152
THR A 176
LEU A 154
 GLC  A 601 (-2.8A)
None
None
None
None
 1.49A 5fhzD-4w8bA:
undetectable		 5fhzD-4w8bA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wls HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CUER

(Escherichia
coli) 		PF13411
(MerR_1) 		5 ILE A   9
GLY A  11
ARG A  51
GLU A  21
LEU A  47
 None
 1.32A 5fhzD-4wlsA:
undetectable		 5fhzD-4wlsA:
11.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		6 GLY A 124
ASN A 169
TRP A 177
GLU A 268
CYH A 301
CYH A 302
 None
TXE  A 501 (-3.5A)
None
TXE  A 501 (-3.6A)
None
TXE  A 501 (-4.4A)
 0.75A 5fhzD-5abmA:
61.1		 5fhzD-5abmA:
68.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		5 GLY A 124
MET A 174
GLU A 268
CYH A 301
CYH A 302
 None
None
TXE  A 501 (-3.6A)
None
TXE  A 501 (-4.4A)
 1.12A 5fhzD-5abmA:
61.1		 5fhzD-5abmA:
68.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Nanoarchaeum
equitans) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		5 ILE A 483
GLU A 486
GLY A 487
GLU A 508
LEU A 544
 None
 1.16A 5fhzD-5bn4A:
undetectable		 5fhzD-5bn4A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es6 LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00551
(Formyl_trans_N) 		5 GLY A 582
ARG A 569
ASN A 479
THR A 491
LEU A 531
 None
 1.30A 5fhzD-5es6A:
3.9		 5fhzD-5es6A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00551
(Formyl_trans_N)
PF13193
(AMP-binding_C) 		5 GLY A 582
ARG A 569
ASN A 479
THR A 491
LEU A 531
 None
 1.42A 5fhzD-5es9A:
3.9		 5fhzD-5es9A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1y MCCC FAMILY PROTEIN

(Bacillus cereus) 		PF02016
(Peptidase_S66) 		5 ILE A 217
GLU A 243
GLY A 215
ASN A 260
LEU A 240
 None
 1.25A 5fhzD-5f1yA:
undetectable		 5fhzD-5f1yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h71 ALGQ2

(Sphingomonas
sp.) 		PF01547
(SBP_bac_1) 		5 ILE A 141
GLU A 143
ASN A 156
THR A 162
LEU A 151
 None
 1.22A 5fhzD-5h71A:
undetectable		 5fhzD-5h71A:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 6 GLY A 123
ASN A 168
MET A 173
TRP A 176
CYH A 302
THR A 303
 None
NAD  A 700 ( 3.0A)
NAD  A 700 (-3.9A)
None
IAC  A 701 ( 2.8A)
IAC  A 701 ( 4.2A)
 0.63A 5fhzD-5iuwA:
56.7		 5fhzD-5iuwA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))

(Thermoplasma
acidophilum) 		PF00171
(Aldedh) 		5 GLY A 103
ASN A 149
MET A 154
GLU A 247
CYH A 281
 None
 0.80A 5fhzD-5izdA:
52.6		 5fhzD-5izdA:
31.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		5 GLU A 175
GLY A 173
GLU A 441
CYH A 133
THR A 167
 None
 0.73A 5fhzD-5jbgA:
undetectable		 5fhzD-5jbgA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		no annotation 5 GLY C 582
ARG C 569
ASN C 479
THR C 491
LEU C 531
 None
 1.29A 5fhzD-5jnfC:
3.9		 5fhzD-5jnfC:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		5 GLU A 153
GLY A 154
ARG A 157
ASN A 113
LEU A 174
 PO4  A 302 ( 4.7A)
None
PO4  A 302 (-2.7A)
None
None
 1.34A 5fhzD-5jzbA:
3.3		 5fhzD-5jzbA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3h POLYMERASE ACIDIC
PROTEIN

(Influenza A
virus) 		PF00603
(Flu_PA) 		5 ILE A 499
GLU A 519
GLY A 497
MET A 304
LEU A 341
 None
 1.34A 5fhzD-5m3hA:
undetectable		 5fhzD-5m3hA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me4 PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN HTXB

(Pseudomonas
stutzeri) 		no annotation 5 ILE A 254
GLU A 255
ARG A 259
ASN A 128
LEU A 261
 None
None
None
HP4  A 301 (-3.1A)
None
 1.49A 5fhzD-5me4A:
undetectable		 5fhzD-5me4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus) 		no annotation 5 ILE A 619
GLU A 620
GLY A 621
ARG A 625
CYH A  83
 None
 1.28A 5fhzD-5n2gA:
undetectable		 5fhzD-5n2gA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oes GLUTATHIONE
SYNTHETASE

(Solanum
tuberosum) 		no annotation 5 ILE A  83
GLU A  86
ARG A  90
CYH A 346
LEU A 330
 None
 1.25A 5fhzD-5oesA:
undetectable		 5fhzD-5oesA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9r CITRATE-SODIUM
SYMPORTER

(Klebsiella
pneumoniae) 		PF03390
(2HCT) 		5 ILE A 321
GLU A 267
GLY A 324
CYH A 278
THR A 277
 None
 1.45A 5fhzD-5x9rA:
undetectable		 5fhzD-5x9rA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjg VACUOLAR PROTEIN 8

(Saccharomyces
cerevisiae) 		PF00514
(Arm) 		5 GLU A 463
TRP A 458
CYH A 445
THR A 487
LEU A 469
 None
 1.43A 5fhzD-5xjgA:
undetectable		 5fhzD-5xjgA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjg VACUOLAR PROTEIN 8

(Saccharomyces
cerevisiae) 		PF00514
(Arm) 		5 ILE A 423
TRP A 458
CYH A 445
THR A 487
LEU A 469
 None
 1.37A 5fhzD-5xjgA:
undetectable		 5fhzD-5xjgA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL

(Homo sapiens) 		PF00384
(Molybdopterin)
PF09326
(NADH_dhqG_C)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		5 GLU M 118
GLY M 115
ASN M  74
CYH M 179
CYH M  64
 None
None
None
SF4  M 802 (-2.7A)
FES  M 803 (-3.2A)
 1.34A 5fhzD-5xtbM:
undetectable		 5fhzD-5xtbM:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b5i RETINAL
DEHYDROGENASE 2

(Homo sapiens) 		no annotation 6 GLY A 142
ASN A 187
MET A 192
CYH A 319
CYH A 320
THR A 321
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.2A)
CU4  A 601 ( 4.7A)
CU4  A 601 ( 4.5A)
CU4  A 601 (-4.2A)
CU4  A 601 (-3.0A)
 0.96A 5fhzD-6b5iA:
61.8		 5fhzD-6b5iA:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b5i RETINAL
DEHYDROGENASE 2

(Homo sapiens) 		no annotation 7 GLY A 142
ASN A 187
MET A 192
TRP A 195
CYH A 319
THR A 321
LEU A 477
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.2A)
CU4  A 601 ( 4.7A)
CU4  A 601 (-4.2A)
CU4  A 601 ( 4.5A)
CU4  A 601 (-3.0A)
CU4  A 601 (-3.8A)
 0.79A 5fhzD-6b5iA:
61.8		 5fhzD-6b5iA:
63.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE

(Salmonella
enterica) 		no annotation 6 ASN A 149
MET A 154
TRP A 157
GLU A 246
CYH A 280
THR A 281
 None
 1.04A 5fhzD-6c43A:
54.4		 5fhzD-6c43A:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE

(Salmonella
enterica) 		no annotation 6 ASN A 149
MET A 154
TRP A 157
GLU A 246
THR A 281
LEU A 438
 None
 0.82A 5fhzD-6c43A:
54.4		 5fhzD-6c43A:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE

(Klebsiella
pneumoniae) 		no annotation 5 ILE A 175
GLU A 176
GLY A 177
ARG A 188
ASN A 242
 None
 1.30A 5fhzD-6duxA:
3.9		 5fhzD-6duxA:
11.79