SIMILAR PATTERNS OF AMINO ACIDS FOR 5FHZ_C_REAC602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)


(Homo sapiens)
PF00079
(Serpin)
5 GLY A 131
GLN A 176
ASN A 127
LEU A 198
LEU A 351
None
1.27A 5fhzC-1by7A:
0.0
5fhzC-1by7A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ept PORCINE E-TRYPSIN

(Sus scrofa)
PF00089
(Trypsin)
5 GLY A  44
GLN C 239
ASN A  48
LEU A  46
LEU B  67
None
1.31A 5fhzC-1eptA:
undetectable
5fhzC-1eptA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE


(Cyberlindnera
saturnus)
PF00291
(PALP)
5 ILE A 138
GLY A 203
THR A 205
PHE A 136
LEU A 323
None
PLP  A 342 (-3.9A)
PLP  A 342 (-3.4A)
None
PLP  A 342 (-3.9A)
1.13A 5fhzC-1f2dA:
2.1
5fhzC-1f2dA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxn PECTATE LYASE

(Cellvibrio
japonicus)
PF09492
(Pec_lyase)
5 ILE A 639
GLY A 559
THR A 507
TRP A 562
LEU A 531
None
1.17A 5fhzC-1gxnA:
undetectable
5fhzC-1gxnA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa)
PF00135
(COesterase)
5 GLY A 124
LEU A 127
GLN A 456
PHE A 133
LEU A 297
None
1.30A 5fhzC-1gz7A:
0.1
5fhzC-1gz7A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus)
PF00089
(Trypsin)
5 GLY T  44
GLN T 239
ASN T  48
LEU T  46
LEU T  68
None
1.33A 5fhzC-1j17T:
undetectable
5fhzC-1j17T:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lsh LIPOVITELLIN (LV-1N,
LV-1C)


(Ichthyomyzon
unicuspis)
PF01347
(Vitellogenin_N)
PF09172
(DUF1943)
5 ILE A 813
GLY A  48
GLN A 236
LEU A  46
LEU A  86
UPL  A2014 ( 4.9A)
UPL  A2014 (-3.7A)
None
UPL  A2014 ( 4.2A)
None
1.10A 5fhzC-1lshA:
undetectable
5fhzC-1lshA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyt SHIKIMATE
5-DEHYDROGENASE


(Escherichia
coli)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N)
5 LEU A 241
GLN A  26
PHE A  23
LEU A 266
LEU A 270
NAP  A1401 (-4.0A)
None
None
None
None
1.22A 5fhzC-1nytA:
4.3
5fhzC-1nytA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj7 ARGININOSUCCINATE
LYASE


(Escherichia
coli)
PF00206
(Lyase_1)
PF14698
(ASL_C2)
5 THR A 142
GLN A 184
ASN A 132
LEU A 135
LEU A 346
None
1.10A 5fhzC-1tj7A:
1.6
5fhzC-1tj7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xew SMC PROTEIN

(Pyrococcus
furiosus)
PF02463
(SMC_N)
5 ILE X 135
GLY X 139
PHE X  86
LEU Y1095
LEU X 144
None
1.16A 5fhzC-1xewX:
undetectable
5fhzC-1xewX:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N


(Mus musculus)
PF00079
(Serpin)
5 ILE A  97
GLY A 100
LEU A 101
LEU A 326
LEU A  58
None
1.33A 5fhzC-1yxaA:
undetectable
5fhzC-1yxaA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus)
PF01229
(Glyco_hydro_39)
5 ILE A  98
GLY A  53
THR A  24
LEU A  27
PHE A 141
None
0.94A 5fhzC-2bs9A:
undetectable
5fhzC-2bs9A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chr CHLOROMUCONATE
CYCLOISOMERASE


(Cupriavidus
necator)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A 120
GLY A 355
GLN A 280
LEU A 309
LEU A 339
None
1.32A 5fhzC-2chrA:
undetectable
5fhzC-2chrA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fsr ACETYLTRANSFERASE

(Agrobacterium
fabrum)
PF13302
(Acetyltransf_3)
5 ILE A  80
GLY A  78
LEU A  97
LEU A  13
LEU A  70
None
None
None
None
FMT  A 301 (-4.6A)
1.21A 5fhzC-2fsrA:
undetectable
5fhzC-2fsrA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjs USG-1 PROTEIN
HOMOLOG


(Pseudomonas
aeruginosa)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 ILE A 332
GLY A 328
LEU A  69
LEU A  24
LEU A  20
None
1.23A 5fhzC-2hjsA:
4.3
5fhzC-2hjsA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00106
(adh_short)
5 GLY A  26
THR A  50
GLN A 226
LEU A   5
LEU A  29
None
1.17A 5fhzC-2nwqA:
4.2
5fhzC-2nwqA:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE


(Rattus
norvegicus)
PF00171
(Aldedh)
5 THR A 529
TRP A 582
PHE A 701
ASN A 864
LEU A 884
None
None
GOL  A   1 ( 4.6A)
GOL  A   1 ( 4.5A)
None
0.67A 5fhzC-2o2qA:
56.2
5fhzC-2o2qA:
44.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy4 NEUTROPHIL
COLLAGENASE


(Homo sapiens)
PF00413
(Peptidase_M10)
5 ILE A 113
THR A 101
LEU A 191
TRP A 182
PHE A 199
None
0.96A 5fhzC-2oy4A:
undetectable
5fhzC-2oy4A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pef SERINE PROTEASE
INHIBITOR


(Caldanaerobacter
subterraneus)
PF00079
(Serpin)
5 ILE A 357
THR A 379
LEU A  92
PHE A 344
LEU A 210
None
1.20A 5fhzC-2pefA:
undetectable
5fhzC-2pefA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pod MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME


(Burkholderia
pseudomallei)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLY A 324
LEU A  17
TRP A  19
LEU A 358
LEU A 382
None
1.15A 5fhzC-2podA:
undetectable
5fhzC-2podA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE


(Salmonella
enterica)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A 194
GLY A 170
LEU A 196
LEU A 180
LEU A 176
None
1.33A 5fhzC-2pp3A:
undetectable
5fhzC-2pp3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ


(Mycobacterium
tuberculosis)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
5 ILE A 225
GLY A 193
THR A 195
LEU A 188
LEU A  32
None
1.25A 5fhzC-2q1yA:
3.2
5fhzC-2q1yA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL


(Homo sapiens)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 ILE A 269
THR A 283
TRP A 277
PHE A 133
LEU A  69
None
1.32A 5fhzC-2wd9A:
3.4
5fhzC-2wd9A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqp POLYSIALIC ACID
CAPSULE BIOSYNTHESIS
PROTEIN SIAC


(Neisseria
meningitidis)
PF03102
(NeuB)
PF08666
(SAF)
5 ILE A 209
GLY A 211
LEU A 180
PHE A   7
LEU A  21
None
1.05A 5fhzC-2wqpA:
undetectable
5fhzC-2wqpA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws9 P1

(Equine rhinitis
A virus)
PF00073
(Rhv)
no annotation
5 ILE 3  44
THR 1  74
LEU 3  93
LEU 1  33
LEU 1  71
None
1.07A 5fhzC-2ws93:
undetectable
5fhzC-2ws93:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET


(Homo sapiens)
PF00028
(Cadherin)
5 GLY A 183
THR A 225
LEU A  56
GLN A  89
PHE A  66
None
1.07A 5fhzC-2x2uA:
undetectable
5fhzC-2x2uA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III


(Thermus
thermophilus)
PF00115
(COX1)
PF00510
(COX3)
5 THR A 731
LEU A 217
PHE A 165
LEU A 631
LEU A 635
None
5PL  A 900 ( 4.9A)
5PL  A 900 (-4.1A)
None
None
1.18A 5fhzC-2yevA:
undetectable
5fhzC-2yevA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6f YETF PROTEIN

(Bacillus
subtilis)
PF04239
(DUF421)
5 ILE A 175
THR A 222
ASN A 183
LEU A 173
LEU A 220
None
1.27A 5fhzC-3c6fA:
undetectable
5fhzC-3c6fA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A 251
GLY A  55
THR A  42
LEU A  51
LEU A  75
None
1.28A 5fhzC-3cmuA:
undetectable
5fhzC-3cmuA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A1251
GLY A1055
THR A1042
LEU A1051
LEU A1075
None
1.29A 5fhzC-3cmuA:
undetectable
5fhzC-3cmuA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A2251
GLY A2055
THR A2042
LEU A2051
LEU A2075
None
1.28A 5fhzC-3cmuA:
undetectable
5fhzC-3cmuA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A3251
GLY A3055
THR A3042
LEU A3051
LEU A3075
None
1.29A 5fhzC-3cmuA:
undetectable
5fhzC-3cmuA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A4251
GLY A4055
THR A4042
LEU A4051
LEU A4075
None
1.28A 5fhzC-3cmuA:
undetectable
5fhzC-3cmuA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A5251
GLY A5055
THR A5042
LEU A5051
LEU A5075
None
1.28A 5fhzC-3cmuA:
undetectable
5fhzC-3cmuA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN


(Pyrococcus
furiosus)
PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB)
5 ILE A 108
GLY A 192
THR A 190
LEU A 200
GLN A 227
None
1.32A 5fhzC-3dm5A:
undetectable
5fhzC-3dm5A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6e ALANINE RACEMASE

(Enterococcus
faecalis)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
5 GLY A 218
THR A  33
PHE A 170
ASN A 206
LEU A  29
None
None
None
DCS  A 372 ( 4.7A)
None
1.21A 5fhzC-3e6eA:
undetectable
5fhzC-3e6eA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eat PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCB


(Pseudomonas
aeruginosa)
PF02668
(TauD)
5 ILE X 251
LEU X  58
PHE X  77
LEU X  49
LEU X  12
None
1.30A 5fhzC-3eatX:
undetectable
5fhzC-3eatX:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evt PHOSPHOGLYCERATE
DEHYDROGENASE


(Lactobacillus
plantarum)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 THR A 217
LEU A 213
ASN A 225
LEU A 223
LEU A 246
None
1.04A 5fhzC-3evtA:
undetectable
5fhzC-3evtA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9t L-TYROSINE
DECARBOXYLASE MFNA


(Methanocaldococcus
jannaschii)
PF00282
(Pyridoxal_deC)
5 ILE A  90
GLY A 288
THR A  55
LEU A  57
LEU A  69
None
1.29A 5fhzC-3f9tA:
undetectable
5fhzC-3f9tA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffy PUTATIVE
TETRAPYRROLE
(CORRIN/PORPHYRIN)
METHYLASE


(Bacteroides
fragilis)
no annotation 5 ILE A 217
THR A 194
GLN A 170
PHE A 171
LEU A 202
None
1.30A 5fhzC-3ffyA:
undetectable
5fhzC-3ffyA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icx PRE MRNA SPLICING
PROTEIN


(Sulfolobus
solfataricus)
PF01798
(Nop)
5 GLY A 270
GLN A 362
PHE A 358
ASN A 264
LEU A 278
None
1.20A 5fhzC-3icxA:
undetectable
5fhzC-3icxA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikf 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE


(Burkholderia
pseudomallei)
PF02542
(YgbB)
5 ILE A 118
GLY A  23
LEU A  42
ASN A 130
LEU A 107
None
1.33A 5fhzC-3ikfA:
undetectable
5fhzC-3ikfA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyn QUINONE
OXIDOREDUCTASE


(Pseudomonas
syringae group
genomosp. 3)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ILE A  43
GLY A  62
LEU A  61
LEU A  40
LEU A 323
None
1.24A 5fhzC-3jynA:
3.6
5fhzC-3jynA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4


(Saccharomyces
cerevisiae)
PF04564
(U-box)
PF10408
(Ufd2P_core)
5 ILE A  95
GLY A  98
GLN A  88
LEU A  43
LEU A  47
None
1.12A 5fhzC-3m62A:
undetectable
5fhzC-3m62A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mst PUTATIVE NITRATE
TRANSPORT PROTEIN


(Thermoplasma
volcanium)
PF12916
(DUF3834)
5 ILE A  43
GLY A  56
THR A 198
LEU A 204
LEU A 138
None
None
CL  A 230 ( 4.8A)
None
None
1.06A 5fhzC-3mstA:
undetectable
5fhzC-3mstA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE


(Enterobacter
cloacae)
PF00328
(His_Phos_2)
5 TRP A  65
GLN A 330
PHE A 374
LEU A   7
LEU A  66
None
1.31A 5fhzC-3ntlA:
undetectable
5fhzC-3ntlA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN


(Leishmania
infantum)
PF00857
(Isochorismatase)
5 GLY A 155
GLN A  62
ASN A  57
LEU A  53
LEU A  38
None
1.27A 5fhzC-3r2jA:
3.3
5fhzC-3r2jA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqx 2-AMINO-3-KETOBUTYRA
TE COENZYME A LIGASE


(Coxiella
burnetii)
PF00155
(Aminotran_1_2)
5 ILE A 188
GLY A 180
LEU A 191
GLN A 302
LEU A 236
None
1.22A 5fhzC-3tqxA:
2.2
5fhzC-3tqxA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vus POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE


(Escherichia
coli)
PF01522
(Polysacc_deac_1)
5 ILE A 127
LEU A  74
TRP A  54
PHE A 131
LEU A 111
None
1.17A 5fhzC-3vusA:
undetectable
5fhzC-3vusA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3s IMINE REDUCTASE

(Nocardiopsis
halophila)
PF03446
(NAD_binding_2)
5 GLY A  20
LEU A  13
ASN A  96
LEU A  97
LEU A 157
None
1.05A 5fhzC-4d3sA:
2.1
5fhzC-4d3sA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7e L-LYS MONOOXYGENASE

(Nocardia
farcinica)
PF13434
(K_oxygenase)
5 ILE A  66
GLY A  10
LEU A 121
TRP A  45
LEU A 401
None
FAD  A 500 (-3.4A)
None
FAD  A 500 (-4.4A)
FAD  A 500 (-3.8A)
1.32A 5fhzC-4d7eA:
undetectable
5fhzC-4d7eA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvf BETA-HEXOSAMINIDASE

(Salmonella
enterica)
PF00933
(Glyco_hydro_3)
5 ILE A 113
LEU A  29
PHE A  71
LEU A  45
LEU A  13
None
1.19A 5fhzC-4gvfA:
undetectable
5fhzC-4gvfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbs PUTATIVE HYDROLASE

(Bacteroides
ovatus)
PF16396
(DUF5005)
5 GLY A 275
THR A 269
TRP A 278
LEU A 191
LEU A 256
None
1.32A 5fhzC-4hbsA:
undetectable
5fhzC-4hbsA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5n SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA -
CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG CHIMERIC
CONSTRUCT


(Homo sapiens)
PF13499
(EF-hand_7)
5 LEU B 238
GLN B 293
PHE B 291
ASN B 294
LEU B 248
None
1.33A 5fhzC-4i5nB:
undetectable
5fhzC-4i5nB:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9


(Saccharomyces
cerevisiae)
PF00022
(Actin)
5 ILE B 194
GLY B 190
THR B 169
LEU B 305
PHE B 219
None
1.10A 5fhzC-4i6mB:
undetectable
5fhzC-4i6mB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4


(Saccharopolyspora
spinosa)
PF08659
(KR)
5 ILE A 111
GLY A 241
LEU A 244
LEU A 102
LEU A 228
None
1.25A 5fhzC-4impA:
5.7
5fhzC-4impA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw5 OXIDOREDUCTASE

(Mycobacterium
tuberculosis)
PF01565
(FAD_binding_4)
PF04030
(ALO)
5 GLY A 176
LEU A 377
TRP A 437
GLN A  65
LEU A 180
None
1.30A 5fhzC-4kw5A:
undetectable
5fhzC-4kw5A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lut ALANINE RACEMASE

(Clostridioides
difficile)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
5 GLY A 163
LEU A 161
GLN A 141
PHE A 140
LEU A 193
None
1.14A 5fhzC-4lutA:
undetectable
5fhzC-4lutA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN


(Klebsiella
pneumoniae)
PF02826
(2-Hacid_dh_C)
5 ILE A 193
GLY A 191
ASN A 222
LEU A 220
LEU A 243
None
1.19A 5fhzC-4n18A:
3.6
5fhzC-4n18A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1a CELL
DIVISIONFTSK/SPOIIIE


(Thermomonospora
curvata)
PF01580
(FtsK_SpoIIIE)
5 ILE A 890
LEU A 953
PHE A 864
LEU A 938
LEU A 960
None
1.33A 5fhzC-4n1aA:
undetectable
5fhzC-4n1aA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzp ARGININOSUCCINATE
SYNTHASE


(Campylobacter
jejuni)
PF00764
(Arginosuc_synth)
5 GLY A 282
THR A 280
PHE A 228
LEU A 287
LEU A  92
None
1.19A 5fhzC-4nzpA:
4.1
5fhzC-4nzpA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN


(Conexibacter
woesei)
PF02608
(Bmp)
5 ILE A  38
THR A 266
TRP A 136
ASN A  50
LEU A 286
None
None
None
BR  A 418 (-3.6A)
None
1.09A 5fhzC-4p98A:
3.0
5fhzC-4p98A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN


(Conexibacter
woesei)
PF02608
(Bmp)
5 THR A 266
TRP A 136
GLN A  43
ASN A  50
LEU A 286
None
None
None
BR  A 418 (-3.6A)
None
1.33A 5fhzC-4p98A:
3.0
5fhzC-4p98A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Dictyostelium
purpureum)
PF05450
(Nicastrin)
5 ILE A 161
GLY A 111
LEU A 191
PHE A 245
LEU A  65
None
0.99A 5fhzC-4r12A:
undetectable
5fhzC-4r12A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY


(Trichormus
variabilis)
PF13458
(Peripla_BP_6)
5 GLY A 279
LEU A 282
GLN A 200
PHE A 229
LEU A  70
None
1.31A 5fhzC-4rdcA:
2.1
5fhzC-4rdcA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkt AT-LESS POLYKETIDE
SYNTHASE


(Streptomyces
platensis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ILE A3493
GLY A3384
PHE A3161
LEU A3204
LEU A3349
None
1.18A 5fhzC-4tktA:
undetectable
5fhzC-4tktA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhh ESTERASE

(Thermogutta
terrifontis)
PF00561
(Abhydrolase_1)
5 ILE A  95
GLY A 120
THR A 214
LEU A 118
LEU A 123
None
1.08A 5fhzC-4uhhA:
undetectable
5fhzC-4uhhA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET


(Homo sapiens)
PF00028
(Cadherin)
5 GLY A 183
THR A 225
LEU A  56
GLN A  89
PHE A  66
None
1.08A 5fhzC-4ux8A:
undetectable
5fhzC-4ux8A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN


(Mycobacterium
tuberculosis)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 ILE A  40
THR A  26
PHE A  49
LEU A  71
LEU A  74
None
1.23A 5fhzC-4xvxA:
undetectable
5fhzC-4xvxA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y67 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE,
APICOPLAST


(Plasmodium
falciparum)
PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C)
5 ILE A  97
THR A 376
LEU A 365
GLN A 124
LEU A 378
None
1.26A 5fhzC-4y67A:
6.2
5fhzC-4y67A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
5 GLY A 595
THR A 569
TRP A 596
GLN A 168
ASN A 220
None
1.14A 5fhzC-4yzwA:
undetectable
5fhzC-4yzwA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE


(Streptomyces
platensis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ILE A 900
GLY A 791
PHE A 573
LEU A 619
LEU A 756
None
1.02A 5fhzC-4zdnA:
undetectable
5fhzC-4zdnA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu9 ELONGATION FACTOR
SELB


(Aquifex
aeolicus)
PF00009
(GTP_EFTU)
PF09107
(SelB-wing_3)
5 GLY A 335
THR A 276
ASN A 331
LEU A 333
LEU A 280
None
1.29A 5fhzC-4zu9A:
2.8
5fhzC-4zu9A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0m INTRON-ENCODED
ENDONUCLEASE I-SCEI


(Saccharomyces
cerevisiae)
PF03161
(LAGLIDADG_2)
5 ILE A 460
GLY A 446
LEU A 462
TRP A 441
LEU A 438
None
1.24A 5fhzC-5a0mA:
undetectable
5fhzC-5a0mA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a35 GLYCINE CLEAVAGE
SYSTEM H PROTEIN


(Streptococcus
pyogenes)
PF01597
(GCV_H)
5 ILE A  19
THR A  38
LEU A  43
ASN A   6
LEU A  62
None
1.18A 5fhzC-5a35A:
undetectable
5fhzC-5a35A:
11.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5abm RETINAL
DEHYDROGENASE 1


(Ovis aries)
PF00171
(Aldedh)
6 GLY A 124
THR A 128
LEU A 173
TRP A 177
GLN A 292
LEU A 477
None
0.86A 5fhzC-5abmA:
61.6
5fhzC-5abmA:
68.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3i HISTIDINE--TRNA
LIGASE


(Acinetobacter
baumannii)
PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His)
5 ILE A 255
THR A 274
LEU A 259
GLN A 240
PHE A 239
None
1.25A 5fhzC-5e3iA:
undetectable
5fhzC-5e3iA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2


(Aeropyrum
pernix)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4)
5 GLY A 225
THR A 227
LEU A  78
LEU A 220
LEU A  83
None
1.29A 5fhzC-5fg3A:
undetectable
5fhzC-5fg3A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE


(Cosenzaea
myxofaciens)
PF01266
(DAO)
5 GLY A 257
THR A 435
LEU A 255
ASN A 267
LEU A 272
FAD  A 500 (-3.5A)
None
None
None
None
1.27A 5fhzC-5fjnA:
undetectable
5fhzC-5fjnA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT


(Sulfolobus
solfataricus)
PF01798
(Nop)
5 GLY A 270
GLN A 362
PHE A 358
ASN A 264
LEU A 278
None
1.30A 5fhzC-5ginA:
undetectable
5fhzC-5ginA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj4 SERINE PROTEASE NS3

(Zika virus)
PF00949
(Peptidase_S7)
5 ILE B 147
TRP B  83
GLN B  96
LEU B 149
LEU B  76
None
1.26A 5fhzC-5gj4B:
undetectable
5fhzC-5gj4B:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxj FLAVIVIRUS_NS2B,LINK
ER,PEPTIDASE S7


(Zika virus;
synthetic
construct)
PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B)
5 ILE A1147
TRP A1083
GLN A1096
LEU A1149
LEU A1076
None
1.07A 5fhzC-5gxjA:
undetectable
5fhzC-5gxjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzk INTERSECTIN-1,NPH1-1
,INTERSECTIN-1


(Avena sativa;
Homo sapiens)
PF00621
(RhoGEF)
PF13426
(PAS_9)
PF16652
(PH_13)
5 ILE B1386
GLY B1360
GLN B1384
ASN B1397
LEU B1358
None
None
None
FMN  B1801 (-4.2A)
FMN  B1801 (-4.2A)
1.33A 5fhzC-5hzkB:
undetectable
5fhzC-5hzkB:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7x DIMETHYLANILINE
MONOOXYGENASE,
PUTATIVE


(Aspergillus
flavus)
PF00743
(FMO-like)
5 GLY A 447
THR A 449
GLN A 514
ASN A 517
LEU A 522
FAD  A 601 (-3.3A)
None
None
None
None
1.33A 5fhzC-5j7xA:
2.1
5fhzC-5j7xA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jos CYCLOHEXADIENYL
DEHYDRATASE


(synthetic
construct)
PF00497
(SBP_bac_3)
5 GLY A  28
THR A  69
PHE A 220
LEU A  78
LEU A  74
None
1.33A 5fhzC-5josA:
undetectable
5fhzC-5josA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA


(Salmonella
enterica)
PF13599
(Pentapeptide_4)
PF13981
(SopA)
5 GLY A 327
LEU A 306
ASN A 269
LEU A 290
LEU A 301
None
1.31A 5fhzC-5jw7A:
undetectable
5fhzC-5jw7A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khl HEMIN ABC
TRANSPORTER,
PERIPLASMIC
HEMIN-BINDING
PROTEIN HUTB


(Vibrio cholerae)
PF01497
(Peripla_BP_2)
5 GLY B  89
LEU B  94
GLN B 122
ASN B 105
LEU B  74
None
1.23A 5fhzC-5khlB:
undetectable
5fhzC-5khlB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mil DUTPASE FAMILY
PROTEIN


(Staphylococcus
aureus)
PF08761
(dUTPase_2)
5 LEU A  68
TRP A  43
ASN A 135
LEU A 136
LEU A  47
None
1.22A 5fhzC-5milA:
undetectable
5fhzC-5milA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nhs BIFUNCTIONAL PROTEIN
FOLD


(Xanthomonas
albilineans)
no annotation 5 ILE A  20
GLY A 154
LEU A 147
LEU A 159
LEU A 188
None
1.10A 5fhzC-5nhsA:
3.7
5fhzC-5nhsA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4m HCGC

(Methanococcus
maripaludis)
PF06690
(DUF1188)
5 GLY A 176
THR A 165
GLN A  74
LEU A 112
LEU A 163
9KH  A 302 ( 3.3A)
None
None
SAH  A 301 (-4.9A)
None
1.18A 5fhzC-5o4mA:
2.1
5fhzC-5o4mA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5j 30S RIBOSOMAL
PROTEIN S4
30S RIBOSOMAL
PROTEIN S5


(Mycolicibacterium
smegmatis)
PF00163
(Ribosomal_S4)
PF00333
(Ribosomal_S5)
PF01479
(S4)
PF03719
(Ribosomal_S5_C)
5 GLY E  69
LEU E 101
GLN D 193
LEU E 140
LEU E 169
None
1.32A 5fhzC-5o5jE:
undetectable
5fhzC-5o5jE:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1v NS2B-NS3
PROTEASE,NS2B-NS3
PROTEASE


(Zika virus)
PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B)
5 ILE A 212
TRP A 148
GLN A 161
LEU A 214
LEU A 141
None
1.23A 5fhzC-5t1vA:
undetectable
5fhzC-5t1vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4m TRANSCRIPTIONAL
REGULATOR


(Streptococcus
dysgalactiae)
no annotation 5 ILE A 145
GLY A 149
LEU A 187
GLN A 139
LEU A 160
None
1.03A 5fhzC-5w4mA:
undetectable
5fhzC-5w4mA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4g AMBP3

(Fischerella
ambigua)
no annotation 5 GLY A  62
THR A  41
GLN A  92
PHE A  95
LEU A  69
None
1.21A 5fhzC-5y4gA:
undetectable
5fhzC-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5za2 BETA-LACTAMASE

(Escherichia
coli)
no annotation 5 GLY A 156
LEU A 217
GLN A 168
ASN A 164
LEU A 161
None
1.18A 5fhzC-5za2A:
undetectable
5fhzC-5za2A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1


(Saccharomyces
cerevisiae)
no annotation 5 ILE A 419
GLY A 421
THR A 423
LEU A 433
LEU A 429
None
1.30A 5fhzC-6az0A:
undetectable
5fhzC-6az0A:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b5i RETINAL
DEHYDROGENASE 2


(Homo sapiens)
no annotation 8 GLY A 142
THR A 146
LEU A 191
TRP A 195
GLN A 310
PHE A 314
ASN A 475
LEU A 477
CU4  A 601 (-3.6A)
CU4  A 601 (-4.4A)
None
CU4  A 601 (-4.2A)
CU4  A 601 (-3.6A)
CU4  A 601 (-3.7A)
CU4  A 601 (-3.7A)
CU4  A 601 (-3.8A)
0.66A 5fhzC-6b5iA:
62.4
5fhzC-6b5iA:
63.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1


(Bos taurus)
no annotation 5 ILE A 395
LEU A 257
GLN A 432
LEU A 616
LEU A 620
None
1.28A 5fhzC-6bhuA:
undetectable
5fhzC-6bhuA:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-)
no annotation 5 GLY A 563
GLN A 588
ASN A 590
LEU A 593
LEU A 625
None
1.29A 5fhzC-6f2tA:
undetectable
5fhzC-6f2tA:
undetectable