SIMILAR PATTERNS OF AMINO ACIDS FOR 5FHZ_C_REAC602
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1by7 | PROTEIN (PLASMINOGENACTIVATORINHIBITOR-2) (Homo sapiens) |
PF00079(Serpin) | 5 | GLY A 131GLN A 176ASN A 127LEU A 198LEU A 351 | None | 1.27A | 5fhzC-1by7A:0.0 | 5fhzC-1by7A:21.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ept | PORCINE E-TRYPSIN (Sus scrofa) |
PF00089(Trypsin) | 5 | GLY A 44GLN C 239ASN A 48LEU A 46LEU B 67 | None | 1.31A | 5fhzC-1eptA:undetectable | 5fhzC-1eptA:10.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f2d | 1-AMINOCYCLOPROPANE-1-CARBOXYLATEDEAMINASE (Cyberlindnerasaturnus) |
PF00291(PALP) | 5 | ILE A 138GLY A 203THR A 205PHE A 136LEU A 323 | NonePLP A 342 (-3.9A)PLP A 342 (-3.4A)NonePLP A 342 (-3.9A) | 1.13A | 5fhzC-1f2dA:2.1 | 5fhzC-1f2dA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gxn | PECTATE LYASE (Cellvibriojaponicus) |
PF09492(Pec_lyase) | 5 | ILE A 639GLY A 559THR A 507TRP A 562LEU A 531 | None | 1.17A | 5fhzC-1gxnA:undetectable | 5fhzC-1gxnA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gz7 | LIPASE 2 (Diutina rugosa) |
PF00135(COesterase) | 5 | GLY A 124LEU A 127GLN A 456PHE A 133LEU A 297 | None | 1.30A | 5fhzC-1gz7A:0.1 | 5fhzC-1gz7A:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j17 | TRYPSIN II, ANIONIC (Rattusnorvegicus) |
PF00089(Trypsin) | 5 | GLY T 44GLN T 239ASN T 48LEU T 46LEU T 68 | None | 1.33A | 5fhzC-1j17T:undetectable | 5fhzC-1j17T:17.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lsh | LIPOVITELLIN (LV-1N,LV-1C) (Ichthyomyzonunicuspis) |
PF01347(Vitellogenin_N)PF09172(DUF1943) | 5 | ILE A 813GLY A 48GLN A 236LEU A 46LEU A 86 | UPL A2014 ( 4.9A)UPL A2014 (-3.7A)NoneUPL A2014 ( 4.2A)None | 1.10A | 5fhzC-1lshA:undetectable | 5fhzC-1lshA:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nyt | SHIKIMATE5-DEHYDROGENASE (Escherichiacoli) |
PF01488(Shikimate_DH)PF08501(Shikimate_dh_N) | 5 | LEU A 241GLN A 26PHE A 23LEU A 266LEU A 270 | NAP A1401 (-4.0A)NoneNoneNoneNone | 1.22A | 5fhzC-1nytA:4.3 | 5fhzC-1nytA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tj7 | ARGININOSUCCINATELYASE (Escherichiacoli) |
PF00206(Lyase_1)PF14698(ASL_C2) | 5 | THR A 142GLN A 184ASN A 132LEU A 135LEU A 346 | None | 1.10A | 5fhzC-1tj7A:1.6 | 5fhzC-1tj7A:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xew | SMC PROTEIN (Pyrococcusfuriosus) |
PF02463(SMC_N) | 5 | ILE X 135GLY X 139PHE X 86LEU Y1095LEU X 144 | None | 1.16A | 5fhzC-1xewX:undetectable | 5fhzC-1xewX:14.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yxa | SERINE (OR CYSTEINE)PROTEINASEINHIBITOR, CLADE A,MEMBER 3N (Mus musculus) |
PF00079(Serpin) | 5 | ILE A 97GLY A 100LEU A 101LEU A 326LEU A 58 | None | 1.33A | 5fhzC-1yxaA:undetectable | 5fhzC-1yxaA:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bs9 | BETA-XYLOSIDASE (Geobacillusstearothermophilus) |
PF01229(Glyco_hydro_39) | 5 | ILE A 98GLY A 53THR A 24LEU A 27PHE A 141 | None | 0.94A | 5fhzC-2bs9A:undetectable | 5fhzC-2bs9A:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2chr | CHLOROMUCONATECYCLOISOMERASE (Cupriavidusnecator) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 120GLY A 355GLN A 280LEU A 309LEU A 339 | None | 1.32A | 5fhzC-2chrA:undetectable | 5fhzC-2chrA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fsr | ACETYLTRANSFERASE (Agrobacteriumfabrum) |
PF13302(Acetyltransf_3) | 5 | ILE A 80GLY A 78LEU A 97LEU A 13LEU A 70 | NoneNoneNoneNoneFMT A 301 (-4.6A) | 1.21A | 5fhzC-2fsrA:undetectable | 5fhzC-2fsrA:15.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hjs | USG-1 PROTEINHOMOLOG (Pseudomonasaeruginosa) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | ILE A 332GLY A 328LEU A 69LEU A 24LEU A 20 | None | 1.23A | 5fhzC-2hjsA:4.3 | 5fhzC-2hjsA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nwq | PROBABLE SHORT-CHAINDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00106(adh_short) | 5 | GLY A 26THR A 50GLN A 226LEU A 5LEU A 29 | None | 1.17A | 5fhzC-2nwqA:4.2 | 5fhzC-2nwqA:21.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2o2q | FORMYLTETRAHYDROFOLATE DEHYDROGENASE (Rattusnorvegicus) |
PF00171(Aldedh) | 5 | THR A 529TRP A 582PHE A 701ASN A 864LEU A 884 | NoneNoneGOL A 1 ( 4.6A)GOL A 1 ( 4.5A)None | 0.67A | 5fhzC-2o2qA:56.2 | 5fhzC-2o2qA:44.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oy4 | NEUTROPHILCOLLAGENASE (Homo sapiens) |
PF00413(Peptidase_M10) | 5 | ILE A 113THR A 101LEU A 191TRP A 182PHE A 199 | None | 0.96A | 5fhzC-2oy4A:undetectable | 5fhzC-2oy4A:15.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pef | SERINE PROTEASEINHIBITOR (Caldanaerobactersubterraneus) |
PF00079(Serpin) | 5 | ILE A 357THR A 379LEU A 92PHE A 344LEU A 210 | None | 1.20A | 5fhzC-2pefA:undetectable | 5fhzC-2pefA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pod | MANDELATE RACEMASE /MUCONATE LACTONIZINGENZYME (Burkholderiapseudomallei) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 324LEU A 17TRP A 19LEU A 358LEU A 382 | None | 1.15A | 5fhzC-2podA:undetectable | 5fhzC-2podA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pp3 | L-TALARATE/GALACTARATE DEHYDRATASE (Salmonellaenterica) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 194GLY A 170LEU A 196LEU A 180LEU A 176 | None | 1.33A | 5fhzC-2pp3A:undetectable | 5fhzC-2pp3A:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q1y | CELL DIVISIONPROTEIN FTSZ (Mycobacteriumtuberculosis) |
PF00091(Tubulin)PF12327(FtsZ_C) | 5 | ILE A 225GLY A 193THR A 195LEU A 188LEU A 32 | None | 1.25A | 5fhzC-2q1yA:3.2 | 5fhzC-2q1yA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wd9 | ACYL-COENZYME ASYNTHETASE ACSM2A,MITOCHONDRIAL (Homo sapiens) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | ILE A 269THR A 283TRP A 277PHE A 133LEU A 69 | None | 1.32A | 5fhzC-2wd9A:3.4 | 5fhzC-2wd9A:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wqp | POLYSIALIC ACIDCAPSULE BIOSYNTHESISPROTEIN SIAC (Neisseriameningitidis) |
PF03102(NeuB)PF08666(SAF) | 5 | ILE A 209GLY A 211LEU A 180PHE A 7LEU A 21 | None | 1.05A | 5fhzC-2wqpA:undetectable | 5fhzC-2wqpA:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ws9 | P1 (Equine rhinitisA virus) |
PF00073(Rhv)no annotation | 5 | ILE 3 44THR 1 74LEU 3 93LEU 1 33LEU 1 71 | None | 1.07A | 5fhzC-2ws93:undetectable | 5fhzC-2ws93:17.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x2u | PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET (Homo sapiens) |
PF00028(Cadherin) | 5 | GLY A 183THR A 225LEU A 56GLN A 89PHE A 66 | None | 1.07A | 5fhzC-2x2uA:undetectable | 5fhzC-2x2uA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yev | CYTOCHROME C OXIDASEPOLYPEPTIDE I+III (Thermusthermophilus) |
PF00115(COX1)PF00510(COX3) | 5 | THR A 731LEU A 217PHE A 165LEU A 631LEU A 635 | None5PL A 900 ( 4.9A)5PL A 900 (-4.1A)NoneNone | 1.18A | 5fhzC-2yevA:undetectable | 5fhzC-2yevA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c6f | YETF PROTEIN (Bacillussubtilis) |
PF04239(DUF421) | 5 | ILE A 175THR A 222ASN A 183LEU A 173LEU A 220 | None | 1.27A | 5fhzC-3c6fA:undetectable | 5fhzC-3c6fA:14.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | ILE A 251GLY A 55THR A 42LEU A 51LEU A 75 | None | 1.28A | 5fhzC-3cmuA:undetectable | 5fhzC-3cmuA:14.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | ILE A1251GLY A1055THR A1042LEU A1051LEU A1075 | None | 1.29A | 5fhzC-3cmuA:undetectable | 5fhzC-3cmuA:14.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | ILE A2251GLY A2055THR A2042LEU A2051LEU A2075 | None | 1.28A | 5fhzC-3cmuA:undetectable | 5fhzC-3cmuA:14.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | ILE A3251GLY A3055THR A3042LEU A3051LEU A3075 | None | 1.29A | 5fhzC-3cmuA:undetectable | 5fhzC-3cmuA:14.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | ILE A4251GLY A4055THR A4042LEU A4051LEU A4075 | None | 1.28A | 5fhzC-3cmuA:undetectable | 5fhzC-3cmuA:14.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | ILE A5251GLY A5055THR A5042LEU A5051LEU A5075 | None | 1.28A | 5fhzC-3cmuA:undetectable | 5fhzC-3cmuA:14.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dm5 | SIGNAL RECOGNITION54 KDA PROTEIN (Pyrococcusfuriosus) |
PF00448(SRP54)PF02881(SRP54_N)PF02978(SRP_SPB) | 5 | ILE A 108GLY A 192THR A 190LEU A 200GLN A 227 | None | 1.32A | 5fhzC-3dm5A:undetectable | 5fhzC-3dm5A:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e6e | ALANINE RACEMASE (Enterococcusfaecalis) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 5 | GLY A 218THR A 33PHE A 170ASN A 206LEU A 29 | NoneNoneNoneDCS A 372 ( 4.7A)None | 1.21A | 5fhzC-3e6eA:undetectable | 5fhzC-3e6eA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eat | PYOVERDINEBIOSYNTHESIS PROTEINPVCB (Pseudomonasaeruginosa) |
PF02668(TauD) | 5 | ILE X 251LEU X 58PHE X 77LEU X 49LEU X 12 | None | 1.30A | 5fhzC-3eatX:undetectable | 5fhzC-3eatX:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3evt | PHOSPHOGLYCERATEDEHYDROGENASE (Lactobacillusplantarum) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | THR A 217LEU A 213ASN A 225LEU A 223LEU A 246 | None | 1.04A | 5fhzC-3evtA:undetectable | 5fhzC-3evtA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f9t | L-TYROSINEDECARBOXYLASE MFNA (Methanocaldococcusjannaschii) |
PF00282(Pyridoxal_deC) | 5 | ILE A 90GLY A 288THR A 55LEU A 57LEU A 69 | None | 1.29A | 5fhzC-3f9tA:undetectable | 5fhzC-3f9tA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ffy | PUTATIVETETRAPYRROLE(CORRIN/PORPHYRIN)METHYLASE (Bacteroidesfragilis) |
no annotation | 5 | ILE A 217THR A 194GLN A 170PHE A 171LEU A 202 | None | 1.30A | 5fhzC-3ffyA:undetectable | 5fhzC-3ffyA:11.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3icx | PRE MRNA SPLICINGPROTEIN (Sulfolobussolfataricus) |
PF01798(Nop) | 5 | GLY A 270GLN A 362PHE A 358ASN A 264LEU A 278 | None | 1.20A | 5fhzC-3icxA:undetectable | 5fhzC-3icxA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ikf | 2-C-METHYL-D-ERYTHRITOL2,4-CYCLODIPHOSPHATESYNTHASE (Burkholderiapseudomallei) |
PF02542(YgbB) | 5 | ILE A 118GLY A 23LEU A 42ASN A 130LEU A 107 | None | 1.33A | 5fhzC-3ikfA:undetectable | 5fhzC-3ikfA:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jyn | QUINONEOXIDOREDUCTASE (Pseudomonassyringae groupgenomosp. 3) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ILE A 43GLY A 62LEU A 61LEU A 40LEU A 323 | None | 1.24A | 5fhzC-3jynA:3.6 | 5fhzC-3jynA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m62 | UBIQUITINCONJUGATION FACTORE4 (Saccharomycescerevisiae) |
PF04564(U-box)PF10408(Ufd2P_core) | 5 | ILE A 95GLY A 98GLN A 88LEU A 43LEU A 47 | None | 1.12A | 5fhzC-3m62A:undetectable | 5fhzC-3m62A:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mst | PUTATIVE NITRATETRANSPORT PROTEIN (Thermoplasmavolcanium) |
PF12916(DUF3834) | 5 | ILE A 43GLY A 56THR A 198LEU A 204LEU A 138 | NoneNone CL A 230 ( 4.8A)NoneNone | 1.06A | 5fhzC-3mstA:undetectable | 5fhzC-3mstA:21.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ntl | ACIDGLUCOSE-1-PHOSPHATEPHOSPHATASE (Enterobactercloacae) |
PF00328(His_Phos_2) | 5 | TRP A 65GLN A 330PHE A 374LEU A 7LEU A 66 | None | 1.31A | 5fhzC-3ntlA:undetectable | 5fhzC-3ntlA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r2j | ALPHA/BETA-HYDROLASE-LIKE PROTEIN (Leishmaniainfantum) |
PF00857(Isochorismatase) | 5 | GLY A 155GLN A 62ASN A 57LEU A 53LEU A 38 | None | 1.27A | 5fhzC-3r2jA:3.3 | 5fhzC-3r2jA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqx | 2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE (Coxiellaburnetii) |
PF00155(Aminotran_1_2) | 5 | ILE A 188GLY A 180LEU A 191GLN A 302LEU A 236 | None | 1.22A | 5fhzC-3tqxA:2.2 | 5fhzC-3tqxA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vus | POLY-BETA-1,6-N-ACETYL-D-GLUCOSAMINEN-DEACETYLASE (Escherichiacoli) |
PF01522(Polysacc_deac_1) | 5 | ILE A 127LEU A 74TRP A 54PHE A 131LEU A 111 | None | 1.17A | 5fhzC-3vusA:undetectable | 5fhzC-3vusA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d3s | IMINE REDUCTASE (Nocardiopsishalophila) |
PF03446(NAD_binding_2) | 5 | GLY A 20LEU A 13ASN A 96LEU A 97LEU A 157 | None | 1.05A | 5fhzC-4d3sA:2.1 | 5fhzC-4d3sA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d7e | L-LYS MONOOXYGENASE (Nocardiafarcinica) |
PF13434(K_oxygenase) | 5 | ILE A 66GLY A 10LEU A 121TRP A 45LEU A 401 | NoneFAD A 500 (-3.4A)NoneFAD A 500 (-4.4A)FAD A 500 (-3.8A) | 1.32A | 5fhzC-4d7eA:undetectable | 5fhzC-4d7eA:25.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gvf | BETA-HEXOSAMINIDASE (Salmonellaenterica) |
PF00933(Glyco_hydro_3) | 5 | ILE A 113LEU A 29PHE A 71LEU A 45LEU A 13 | None | 1.19A | 5fhzC-4gvfA:undetectable | 5fhzC-4gvfA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hbs | PUTATIVE HYDROLASE (Bacteroidesovatus) |
PF16396(DUF5005) | 5 | GLY A 275THR A 269TRP A 278LEU A 191LEU A 256 | None | 1.32A | 5fhzC-4hbsA:undetectable | 5fhzC-4hbsA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i5n | SERINE/THREONINE-PROTEIN PHOSPHATASE 2AREGULATORY SUBUNITB'' SUBUNIT BETA -CELL DIVISIONCONTROL PROTEIN 6HOMOLOG CHIMERICCONSTRUCT (Homo sapiens) |
PF13499(EF-hand_7) | 5 | LEU B 238GLN B 293PHE B 291ASN B 294LEU B 248 | None | 1.33A | 5fhzC-4i5nB:undetectable | 5fhzC-4i5nB:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i6m | ACTIN-LIKE PROTEINARP9 (Saccharomycescerevisiae) |
PF00022(Actin) | 5 | ILE B 194GLY B 190THR B 169LEU B 305PHE B 219 | None | 1.10A | 5fhzC-4i6mB:undetectable | 5fhzC-4i6mB:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4imp | POLYKETIDE SYNTHASEEXTENDER MODULES 3-4 (Saccharopolysporaspinosa) |
PF08659(KR) | 5 | ILE A 111GLY A 241LEU A 244LEU A 102LEU A 228 | None | 1.25A | 5fhzC-4impA:5.7 | 5fhzC-4impA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kw5 | OXIDOREDUCTASE (Mycobacteriumtuberculosis) |
PF01565(FAD_binding_4)PF04030(ALO) | 5 | GLY A 176LEU A 377TRP A 437GLN A 65LEU A 180 | None | 1.30A | 5fhzC-4kw5A:undetectable | 5fhzC-4kw5A:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lut | ALANINE RACEMASE (Clostridioidesdifficile) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 5 | GLY A 163LEU A 161GLN A 141PHE A 140LEU A 193 | None | 1.14A | 5fhzC-4lutA:undetectable | 5fhzC-4lutA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n18 | D-ISOMER SPECIFIC2-HYDROXYACIDDEHYDROGENASE FAMILYPROTEIN (Klebsiellapneumoniae) |
PF02826(2-Hacid_dh_C) | 5 | ILE A 193GLY A 191ASN A 222LEU A 220LEU A 243 | None | 1.19A | 5fhzC-4n18A:3.6 | 5fhzC-4n18A:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n1a | CELLDIVISIONFTSK/SPOIIIE (Thermomonosporacurvata) |
PF01580(FtsK_SpoIIIE) | 5 | ILE A 890LEU A 953PHE A 864LEU A 938LEU A 960 | None | 1.33A | 5fhzC-4n1aA:undetectable | 5fhzC-4n1aA:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nzp | ARGININOSUCCINATESYNTHASE (Campylobacterjejuni) |
PF00764(Arginosuc_synth) | 5 | GLY A 282THR A 280PHE A 228LEU A 287LEU A 92 | None | 1.19A | 5fhzC-4nzpA:4.1 | 5fhzC-4nzpA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p98 | EXTRACELLULARSOLUTE-BINDINGPROTEIN (Conexibacterwoesei) |
PF02608(Bmp) | 5 | ILE A 38THR A 266TRP A 136ASN A 50LEU A 286 | NoneNoneNone BR A 418 (-3.6A)None | 1.09A | 5fhzC-4p98A:3.0 | 5fhzC-4p98A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p98 | EXTRACELLULARSOLUTE-BINDINGPROTEIN (Conexibacterwoesei) |
PF02608(Bmp) | 5 | THR A 266TRP A 136GLN A 43ASN A 50LEU A 286 | NoneNoneNone BR A 418 (-3.6A)None | 1.33A | 5fhzC-4p98A:3.0 | 5fhzC-4p98A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r12 | PUTATIVEUNCHARACTERIZEDPROTEIN (Dictyosteliumpurpureum) |
PF05450(Nicastrin) | 5 | ILE A 161GLY A 111LEU A 191PHE A 245LEU A 65 | None | 0.99A | 5fhzC-4r12A:undetectable | 5fhzC-4r12A:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rdc | AMINO ACID/AMIDE ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN, HAAT FAMILY (Trichormusvariabilis) |
PF13458(Peripla_BP_6) | 5 | GLY A 279LEU A 282GLN A 200PHE A 229LEU A 70 | None | 1.31A | 5fhzC-4rdcA:2.1 | 5fhzC-4rdcA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tkt | AT-LESS POLYKETIDESYNTHASE (Streptomycesplatensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | ILE A3493GLY A3384PHE A3161LEU A3204LEU A3349 | None | 1.18A | 5fhzC-4tktA:undetectable | 5fhzC-4tktA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uhh | ESTERASE (Thermoguttaterrifontis) |
PF00561(Abhydrolase_1) | 5 | ILE A 95GLY A 120THR A 214LEU A 118LEU A 123 | None | 1.08A | 5fhzC-4uhhA:undetectable | 5fhzC-4uhhA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ux8 | PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET (Homo sapiens) |
PF00028(Cadherin) | 5 | GLY A 183THR A 225LEU A 56GLN A 89PHE A 66 | None | 1.08A | 5fhzC-4ux8A:undetectable | 5fhzC-4ux8A:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xvx | ACYL-[ACYL-CARRIER-PROTEIN]DEHYDROGENASE MBTN (Mycobacteriumtuberculosis) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | ILE A 40THR A 26PHE A 49LEU A 71LEU A 74 | None | 1.23A | 5fhzC-4xvxA:undetectable | 5fhzC-4xvxA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y67 | 1-DEOXY-D-XYLULOSE5-PHOSPHATEREDUCTOISOMERASE,APICOPLAST (Plasmodiumfalciparum) |
PF02670(DXP_reductoisom)PF08436(DXP_redisom_C)PF13288(DXPR_C) | 5 | ILE A 97THR A 376LEU A 365GLN A 124LEU A 378 | None | 1.26A | 5fhzC-4y67A:6.2 | 5fhzC-4y67A:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yzw | AGAP004976-PA (Anophelesgambiae) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 5 | GLY A 595THR A 569TRP A 596GLN A 168ASN A 220 | None | 1.14A | 5fhzC-4yzwA:undetectable | 5fhzC-4yzwA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zdn | AT-LESS POLYKETIDESYNTHASE (Streptomycesplatensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | ILE A 900GLY A 791PHE A 573LEU A 619LEU A 756 | None | 1.02A | 5fhzC-4zdnA:undetectable | 5fhzC-4zdnA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zu9 | ELONGATION FACTORSELB (Aquifexaeolicus) |
PF00009(GTP_EFTU)PF09107(SelB-wing_3) | 5 | GLY A 335THR A 276ASN A 331LEU A 333LEU A 280 | None | 1.29A | 5fhzC-4zu9A:2.8 | 5fhzC-4zu9A:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a0m | INTRON-ENCODEDENDONUCLEASE I-SCEI (Saccharomycescerevisiae) |
PF03161(LAGLIDADG_2) | 5 | ILE A 460GLY A 446LEU A 462TRP A 441LEU A 438 | None | 1.24A | 5fhzC-5a0mA:undetectable | 5fhzC-5a0mA:17.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a35 | GLYCINE CLEAVAGESYSTEM H PROTEIN (Streptococcuspyogenes) |
PF01597(GCV_H) | 5 | ILE A 19THR A 38LEU A 43ASN A 6LEU A 62 | None | 1.18A | 5fhzC-5a35A:undetectable | 5fhzC-5a35A:11.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5abm | RETINALDEHYDROGENASE 1 (Ovis aries) |
PF00171(Aldedh) | 6 | GLY A 124THR A 128LEU A 173TRP A 177GLN A 292LEU A 477 | None | 0.86A | 5fhzC-5abmA:61.6 | 5fhzC-5abmA:68.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e3i | HISTIDINE--TRNALIGASE (Acinetobacterbaumannii) |
PF03129(HGTP_anticodon)PF13393(tRNA-synt_His) | 5 | ILE A 255THR A 274LEU A 259GLN A 240PHE A 239 | None | 1.25A | 5fhzC-5e3iA:undetectable | 5fhzC-5e3iA:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fg3 | PROBABLE TRANSLATIONINITIATION FACTORIF-2 (Aeropyrumpernix) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2)PF11987(IF-2)PF14578(GTP_EFTU_D4) | 5 | GLY A 225THR A 227LEU A 78LEU A 220LEU A 83 | None | 1.29A | 5fhzC-5fg3A:undetectable | 5fhzC-5fg3A:23.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fjn | L-AMINO ACIDDEAMINASE (Cosenzaeamyxofaciens) |
PF01266(DAO) | 5 | GLY A 257THR A 435LEU A 255ASN A 267LEU A 272 | FAD A 500 (-3.5A)NoneNoneNoneNone | 1.27A | 5fhzC-5fjnA:undetectable | 5fhzC-5fjnA:24.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gin | C/D BOX METHYLATIONGUIDERIBONUCLEOPROTEINCOMPLEX ANOP56SUBUNIT (Sulfolobussolfataricus) |
PF01798(Nop) | 5 | GLY A 270GLN A 362PHE A 358ASN A 264LEU A 278 | None | 1.30A | 5fhzC-5ginA:undetectable | 5fhzC-5ginA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gj4 | SERINE PROTEASE NS3 (Zika virus) |
PF00949(Peptidase_S7) | 5 | ILE B 147TRP B 83GLN B 96LEU B 149LEU B 76 | None | 1.26A | 5fhzC-5gj4B:undetectable | 5fhzC-5gj4B:15.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gxj | FLAVIVIRUS_NS2B,LINKER,PEPTIDASE S7 (Zika virus;syntheticconstruct) |
PF00949(Peptidase_S7)PF01002(Flavi_NS2B) | 5 | ILE A1147TRP A1083GLN A1096LEU A1149LEU A1076 | None | 1.07A | 5fhzC-5gxjA:undetectable | 5fhzC-5gxjA:17.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hzk | INTERSECTIN-1,NPH1-1,INTERSECTIN-1 (Avena sativa;Homo sapiens) |
PF00621(RhoGEF)PF13426(PAS_9)PF16652(PH_13) | 5 | ILE B1386GLY B1360GLN B1384ASN B1397LEU B1358 | NoneNoneNoneFMN B1801 (-4.2A)FMN B1801 (-4.2A) | 1.33A | 5fhzC-5hzkB:undetectable | 5fhzC-5hzkB:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j7x | DIMETHYLANILINEMONOOXYGENASE,PUTATIVE (Aspergillusflavus) |
PF00743(FMO-like) | 5 | GLY A 447THR A 449GLN A 514ASN A 517LEU A 522 | FAD A 601 (-3.3A)NoneNoneNoneNone | 1.33A | 5fhzC-5j7xA:2.1 | 5fhzC-5j7xA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jos | CYCLOHEXADIENYLDEHYDRATASE (syntheticconstruct) |
PF00497(SBP_bac_3) | 5 | GLY A 28THR A 69PHE A 220LEU A 78LEU A 74 | None | 1.33A | 5fhzC-5josA:undetectable | 5fhzC-5josA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jw7 | E3 UBIQUITIN-PROTEINLIGASE SOPA (Salmonellaenterica) |
PF13599(Pentapeptide_4)PF13981(SopA) | 5 | GLY A 327LEU A 306ASN A 269LEU A 290LEU A 301 | None | 1.31A | 5fhzC-5jw7A:undetectable | 5fhzC-5jw7A:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5khl | HEMIN ABCTRANSPORTER,PERIPLASMICHEMIN-BINDINGPROTEIN HUTB (Vibrio cholerae) |
PF01497(Peripla_BP_2) | 5 | GLY B 89LEU B 94GLN B 122ASN B 105LEU B 74 | None | 1.23A | 5fhzC-5khlB:undetectable | 5fhzC-5khlB:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mil | DUTPASE FAMILYPROTEIN (Staphylococcusaureus) |
PF08761(dUTPase_2) | 5 | LEU A 68TRP A 43ASN A 135LEU A 136LEU A 47 | None | 1.22A | 5fhzC-5milA:undetectable | 5fhzC-5milA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nhs | BIFUNCTIONAL PROTEINFOLD (Xanthomonasalbilineans) |
no annotation | 5 | ILE A 20GLY A 154LEU A 147LEU A 159LEU A 188 | None | 1.10A | 5fhzC-5nhsA:3.7 | 5fhzC-5nhsA:10.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o4m | HCGC (Methanococcusmaripaludis) |
PF06690(DUF1188) | 5 | GLY A 176THR A 165GLN A 74LEU A 112LEU A 163 | 9KH A 302 ( 3.3A)NoneNoneSAH A 301 (-4.9A)None | 1.18A | 5fhzC-5o4mA:2.1 | 5fhzC-5o4mA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o5j | 30S RIBOSOMALPROTEIN S430S RIBOSOMALPROTEIN S5 (Mycolicibacteriumsmegmatis) |
PF00163(Ribosomal_S4)PF00333(Ribosomal_S5)PF01479(S4)PF03719(Ribosomal_S5_C) | 5 | GLY E 69LEU E 101GLN D 193LEU E 140LEU E 169 | None | 1.32A | 5fhzC-5o5jE:undetectable | 5fhzC-5o5jE:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t1v | NS2B-NS3PROTEASE,NS2B-NS3PROTEASE (Zika virus) |
PF00949(Peptidase_S7)PF01002(Flavi_NS2B) | 5 | ILE A 212TRP A 148GLN A 161LEU A 214LEU A 141 | None | 1.23A | 5fhzC-5t1vA:undetectable | 5fhzC-5t1vA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w4m | TRANSCRIPTIONALREGULATOR (Streptococcusdysgalactiae) |
no annotation | 5 | ILE A 145GLY A 149LEU A 187GLN A 139LEU A 160 | None | 1.03A | 5fhzC-5w4mA:undetectable | 5fhzC-5w4mA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y4g | AMBP3 (Fischerellaambigua) |
no annotation | 5 | GLY A 62THR A 41GLN A 92PHE A 95LEU A 69 | None | 1.21A | 5fhzC-5y4gA:undetectable | 5fhzC-5y4gA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5za2 | BETA-LACTAMASE (Escherichiacoli) |
no annotation | 5 | GLY A 156LEU A 217GLN A 168ASN A 164LEU A 161 | None | 1.18A | 5fhzC-5za2A:undetectable | 5fhzC-5za2A:10.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6az0 | MITOCHONDRIAL INNERMEMBRANE I-AAAPROTEASESUPERCOMPLEX SUBUNITYME1 (Saccharomycescerevisiae) |
no annotation | 5 | ILE A 419GLY A 421THR A 423LEU A 433LEU A 429 | None | 1.30A | 5fhzC-6az0A:undetectable | 5fhzC-6az0A:21.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6b5i | RETINALDEHYDROGENASE 2 (Homo sapiens) |
no annotation | 8 | GLY A 142THR A 146LEU A 191TRP A 195GLN A 310PHE A 314ASN A 475LEU A 477 | CU4 A 601 (-3.6A)CU4 A 601 (-4.4A)NoneCU4 A 601 (-4.2A)CU4 A 601 (-3.6A)CU4 A 601 (-3.7A)CU4 A 601 (-3.7A)CU4 A 601 (-3.8A) | 0.66A | 5fhzC-6b5iA:62.4 | 5fhzC-6b5iA:63.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bhu | MULTIDRUGRESISTANCE-ASSOCIATED PROTEIN 1 (Bos taurus) |
no annotation | 5 | ILE A 395LEU A 257GLN A 432LEU A 616LEU A 620 | None | 1.28A | 5fhzC-6bhuA:undetectable | 5fhzC-6bhuA:0.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f2t | - (-) |
no annotation | 5 | GLY A 563GLN A 588ASN A 590LEU A 593LEU A 625 | None | 1.29A | 5fhzC-6f2tA:undetectable | 5fhzC-6f2tA:undetectable |