SIMILAR PATTERNS OF AMINO ACIDS FOR 5FHZ_B_REAB602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)

(Homo sapiens) 		PF00079
(Serpin) 		5 GLY A 131
GLN A 176
ASN A 127
LEU A 198
LEU A 351
 None
 1.38A 5fhzB-1by7A:
undetectable		 5fhzB-1by7A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7u 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Escherichia
coli) 		PF00793
(DAHP_synth_1) 		5 GLY A  23
LEU A  21
GLN A 205
LEU A 255
LEU A 260
 None
None
PEP  A 300 ( 3.8A)
None
None
 1.45A 5fhzB-1g7uA:
undetectable		 5fhzB-1g7uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxn PECTATE LYASE

(Cellvibrio
japonicus) 		PF09492
(Pec_lyase) 		5 ILE A 639
GLY A 559
THR A 507
TRP A 562
LEU A 531
 None
 1.15A 5fhzB-1gxnA:
undetectable		 5fhzB-1gxnA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hux ACTIVATOR OF
(R)-2-HYDROXYGLUTARY
L-COA DEHYDRATASE

(Acidaminococcus
fermentans) 		PF01869
(BcrAD_BadFG) 		5 GLY A   7
THR A   5
ASN A 245
LEU A 248
LEU A  20
 None
 1.34A 5fhzB-1huxA:
0.5		 5fhzB-1huxA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jug LYSOZYME

(Tachyglossus
aculeatus) 		PF00062
(Lys) 		5 ILE A  88
THR A  31
LEU A  56
TRP A 108
LEU A 105
 None
 1.39A 5fhzB-1jugA:
undetectable		 5fhzB-1jugA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrr SEQA PROTEIN

(Escherichia
coli) 		PF03925
(SeqA) 		5 THR A 180
LEU A  94
GLN A 168
LEU A 173
LEU A  76
 None
 1.42A 5fhzB-1lrrA:
undetectable		 5fhzB-1lrrA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lsh LIPOVITELLIN (LV-1N,
LV-1C)

(Ichthyomyzon
unicuspis) 		PF01347
(Vitellogenin_N)
PF09172
(DUF1943) 		5 ILE A 813
GLY A  48
GLN A 236
LEU A  46
LEU A  86
 UPL  A2014 ( 4.9A)
UPL  A2014 (-3.7A)
None
UPL  A2014 ( 4.2A)
None
 1.20A 5fhzB-1lshA:
undetectable		 5fhzB-1lshA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		5 GLY A 145
THR A 225
GLN A 599
LEU A 136
LEU A 133
 None
 1.48A 5fhzB-1m1cA:
0.0		 5fhzB-1m1cA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		5 ILE A 397
GLY A 366
LEU A 347
LEU A 413
LEU A 410
 None
 1.28A 5fhzB-1mlzA:
0.9		 5fhzB-1mlzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9p TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Escherichia
coli) 		PF01746
(tRNA_m1G_MT) 		5 GLY A 214
THR A 216
LEU A 237
LEU A 209
LEU A 175
 None
 1.24A 5fhzB-1p9pA:
undetectable		 5fhzB-1p9pA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN

(Pseudomonas
aeruginosa) 		PF13433
(Peripla_BP_5) 		5 ILE A  71
GLY A  11
ASN A 116
LEU A 101
LEU A 296
 None
 1.34A 5fhzB-1qnlA:
3.1		 5fhzB-1qnlA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqg METHIONYL-TRNA
SYNTHETASE

(Pyrococcus
abyssi) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		5 ILE A 392
THR A 372
GLN A 552
LEU A 367
LEU A  27
 None
 1.42A 5fhzB-1rqgA:
3.1		 5fhzB-1rqgA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqg METHIONYL-TRNA
SYNTHETASE

(Pyrococcus
abyssi) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		5 THR A 372
LEU A 508
GLN A 552
LEU A 367
LEU A  27
 None
 1.44A 5fhzB-1rqgA:
3.1		 5fhzB-1rqgA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tc1 PROTEIN
(HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE)

(Trypanosoma
cruzi) 		PF00156
(Pribosyltran) 		5 ILE A 102
THR A 137
LEU A 135
LEU A 123
LEU A 120
 None
None
None
None
MES  A 800 (-3.8A)
 1.28A 5fhzB-1tc1A:
undetectable		 5fhzB-1tc1A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj7 ARGININOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		5 THR A 142
GLN A 184
ASN A 132
LEU A 135
LEU A 346
 None
 1.11A 5fhzB-1tj7A:
undetectable		 5fhzB-1tj7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ud3 AMYLASE

(Bacillus sp.
KSM-K38) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 ILE A 307
THR A 353
GLN A 298
ASN A 427
LEU A 346
 None
None
None
NA  A1002 (-2.6A)
None
 1.29A 5fhzB-1ud3A:
undetectable		 5fhzB-1ud3A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmf HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF01894
(UPF0047) 		5 ILE A  46
GLY A  92
THR A  90
GLN A  20
LEU A  64
 None
 1.46A 5fhzB-1vmfA:
undetectable		 5fhzB-1vmfA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq1 PUTATIVE TROPINONE
REDUCATSE

(Arabidopsis
thaliana) 		PF13561
(adh_short_C2) 		5 GLY A 169
THR A 167
ASN A 177
LEU A 174
LEU A 124
 None
 1.37A 5fhzB-1xq1A:
5.8		 5fhzB-1xq1A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1

(Medicago
truncatula) 		PF00201
(UDPGT) 		5 ILE A 373
GLY A 353
LEU A 422
GLN A 382
LEU A 281
 None
None
None
UDP  A 900 ( 4.6A)
None
 1.35A 5fhzB-2acvA:
4.0		 5fhzB-2acvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chr CHLOROMUCONATE
CYCLOISOMERASE

(Cupriavidus
necator) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 120
GLY A 355
GLN A 280
LEU A 309
LEU A 339
 None
 1.39A 5fhzB-2chrA:
undetectable		 5fhzB-2chrA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f28 SIALIDASE 2

(Homo sapiens) 		PF13088
(BNR_2) 		5 ILE A 362
THR A 296
GLN A  71
LEU A  25
LEU A 337
 None
 1.35A 5fhzB-2f28A:
undetectable		 5fhzB-2f28A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gkp HYPOTHETICAL PROTEIN
NMB0488

(Neisseria
meningitidis) 		PF07262
(CdiI) 		5 ILE A  22
GLY A  52
LEU A 156
LEU A  59
LEU A 120
 None
 1.42A 5fhzB-2gkpA:
undetectable		 5fhzB-2gkpA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350

(Human
gammaherpesvirus
4) 		PF05109
(Herpes_BLLF1) 		5 ILE A 115
GLY A  84
LEU A  61
LEU A 111
LEU A  91
 NDG  A1114 ( 4.7A)
None
None
None
None
 1.37A 5fhzB-2h6oA:
undetectable		 5fhzB-2h6oA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5t GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01472
(PUA) 		5 ILE A  45
THR A  49
TRP A  87
LEU A  31
LEU A  16
 None
 1.42A 5fhzB-2j5tA:
3.7		 5fhzB-2j5tA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg7 ANTIQUITIN

(Acanthopagrus
schlegelii) 		PF00171
(Aldedh) 		5 ILE A  88
LEU A 180
TRP A  73
ASN A 212
LEU A 214
 None
 1.37A 5fhzB-2jg7A:
45.9		 5fhzB-2jg7A:
29.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00106
(adh_short) 		5 GLY A  26
THR A  50
GLN A 226
LEU A   5
LEU A  29
 None
 1.18A 5fhzB-2nwqA:
4.1		 5fhzB-2nwqA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		5 ILE A 272
THR A 224
ASN A 265
LEU A 198
LEU A 226
 None
 1.44A 5fhzB-2qzwA:
undetectable		 5fhzB-2qzwA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2raa PYRUVATE SYNTHASE
SUBUNIT PORC

(Thermotoga
maritima) 		PF01558
(POR) 		5 GLY A 184
GLN A  18
ASN A 138
LEU A 142
LEU A 154
 None
 1.41A 5fhzB-2raaA:
undetectable		 5fhzB-2raaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w21 GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		5 ILE A  45
THR A  49
TRP A  87
LEU A  31
LEU A  16
 None
 1.43A 5fhzB-2w21A:
5.8		 5fhzB-2w21A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
1A

(Mus musculus) 		PF06470
(SMC_hinge) 		5 GLY A 517
LEU A 522
ASN A 541
LEU A 571
LEU A 573
 None
 1.23A 5fhzB-2wd5A:
undetectable		 5fhzB-2wd5A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws9 P1

(Equine rhinitis
A virus) 		PF00073
(Rhv)
no annotation 		5 ILE 3  44
THR 1  74
LEU 3  93
LEU 1  33
LEU 1  71
 None
 1.10A 5fhzB-2ws93:
undetectable		 5fhzB-2ws93:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsi FAD SYNTHETASE

(Saccharomyces
cerevisiae) 		PF01507
(PAPS_reduct) 		5 ILE A 165
THR A  37
LEU A  69
LEU A 191
LEU A  41
 FAD  A2762 (-4.5A)
None
None
None
None
 1.22A 5fhzB-2wsiA:
2.7		 5fhzB-2wsiA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN

(Bordetella
bronchiseptica) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 GLY A 460
LEU A 412
TRP A 423
GLN A 152
LEU A 455
 None
 1.48A 5fhzB-2x0qA:
undetectable		 5fhzB-2x0qA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 206
GLY A 202
LEU A 251
TRP A 199
ASN A 215
 None
 1.42A 5fhzB-2xikA:
undetectable		 5fhzB-2xikA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtq COLICIN-M

(Escherichia
coli) 		PF14859
(Colicin_M) 		5 ILE A 263
THR A 185
LEU A 201
ASN A 147
LEU A 196
 None
 1.40A 5fhzB-2xtqA:
undetectable		 5fhzB-2xtqA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b70 ENOYL REDUCTASE

(Aspergillus
terreus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 285
GLY A 141
LEU A 311
GLN A  94
LEU A 324
 None
 1.01A 5fhzB-3b70A:
3.9		 5fhzB-3b70A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6f YETF PROTEIN

(Bacillus
subtilis) 		PF04239
(DUF421) 		5 ILE A 175
THR A 222
ASN A 183
LEU A 173
LEU A 220
 None
 1.29A 5fhzB-3c6fA:
undetectable		 5fhzB-3c6fA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ILE A 251
GLY A  55
THR A  42
LEU A  51
LEU A  75
 None
 1.20A 5fhzB-3cmuA:
undetectable		 5fhzB-3cmuA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ILE A1251
GLY A1055
THR A1042
LEU A1051
LEU A1075
 None
 1.20A 5fhzB-3cmuA:
undetectable		 5fhzB-3cmuA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ILE A2251
GLY A2055
THR A2042
LEU A2051
LEU A2075
 None
 1.20A 5fhzB-3cmuA:
undetectable		 5fhzB-3cmuA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ILE A3251
GLY A3055
THR A3042
LEU A3051
LEU A3075
 None
 1.20A 5fhzB-3cmuA:
undetectable		 5fhzB-3cmuA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ILE A4251
GLY A4055
THR A4042
LEU A4051
LEU A4075
 None
 1.20A 5fhzB-3cmuA:
undetectable		 5fhzB-3cmuA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ILE A5251
GLY A5055
THR A5042
LEU A5051
LEU A5075
 None
 1.20A 5fhzB-3cmuA:
undetectable		 5fhzB-3cmuA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e54 RRNA INTRON-ENCODED
ENDONUCLEASE

(Vulcanisaeta
distributa) 		PF00961
(LAGLIDADG_1) 		5 ILE A 111
GLY A 114
LEU A 115
LEU A 126
LEU A 121
 None
 1.25A 5fhzB-3e54A:
undetectable		 5fhzB-3e54A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2

(Homo sapiens) 		PF05527
(DUF758) 		5 GLY A  80
LEU A  84
ASN A  76
LEU A  73
LEU A 130
 CL  A 201 (-3.6A)
None
None
None
None
 1.47A 5fhzB-3f4mA:
undetectable		 5fhzB-3f4mA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9t L-TYROSINE
DECARBOXYLASE MFNA

(Methanocaldococcus
jannaschii) 		PF00282
(Pyridoxal_deC) 		5 ILE A  90
GLY A 288
THR A  55
LEU A  57
LEU A  69
 None
 1.23A 5fhzB-3f9tA:
undetectable		 5fhzB-3f9tA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX5

(Homo sapiens) 		PF00270
(DEAD) 		5 ILE A 169
GLY A 167
THR A 237
GLN A 274
LEU A 232
 None
 1.43A 5fhzB-3fe2A:
4.3		 5fhzB-3fe2A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj1 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Ruegeria
pomeroyi) 		PF01380
(SIS) 		5 GLY A 258
THR A 286
LEU A 269
ASN A 220
LEU A 311
 None
 1.24A 5fhzB-3fj1A:
undetectable		 5fhzB-3fj1A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		5 ILE A  95
GLY A  98
GLN A  88
LEU A  43
LEU A  47
 None
 1.17A 5fhzB-3m62A:
undetectable		 5fhzB-3m62A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mst PUTATIVE NITRATE
TRANSPORT PROTEIN

(Thermoplasma
volcanium) 		PF12916
(DUF3834) 		5 ILE A  43
GLY A  56
THR A 198
LEU A 204
LEU A 138
 None
None
CL  A 230 ( 4.8A)
None
None
 1.09A 5fhzB-3mstA:
undetectable		 5fhzB-3mstA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjx CYCLIC DIMERIC GMP
BINDING PROTEIN

(Pseudomonas
fluorescens) 		PF00563
(EAL)
PF00990
(GGDEF) 		5 GLY A 576
THR A 547
LEU A 577
GLN A 225
LEU A 543
 None
EDO  A   3 (-4.6A)
None
None
None
 1.37A 5fhzB-3pjxA:
undetectable		 5fhzB-3pjxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1j SERINE PROTEASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7) 		5 THR B 168
TRP B  83
GLN B  96
LEU B 149
LEU B  76
 None
 1.35A 5fhzB-3u1jB:
undetectable		 5fhzB-3u1jB:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w36 NAPH1

(Streptomyces
sp. CNQ525) 		no annotation 5 THR A 266
GLN A 142
ASN A  95
LEU A  92
LEU A 365
 None
 1.36A 5fhzB-3w36A:
undetectable		 5fhzB-3w36A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		5 ILE B2025
THR B2017
LEU B2058
GLN B2047
LEU B2010
 None
 1.38A 5fhzB-3zefB:
undetectable		 5fhzB-3zefB:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		5 GLY A 496
LEU A 499
GLN A 544
LEU A 494
LEU A 467
 None
 1.43A 5fhzB-3zgbA:
undetectable		 5fhzB-3zgbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3r ENOLASE

(Bacillus
subtilis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A 167
THR A 221
LEU A 189
ASN A 148
LEU A 212
 None
 1.38A 5fhzB-4a3rA:
undetectable		 5fhzB-4a3rA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2

(Mus musculus) 		PF07528
(DZF) 		5 ILE A 329
GLY A 331
GLN A 273
LEU A 226
LEU A  64
 None
 1.44A 5fhzB-4atbA:
undetectable		 5fhzB-4atbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bu0 S-M CHECKPOINT
CONTROL PROTEIN RAD4

(Schizosaccharomyces
pombe) 		PF12738
(PTCB-BRCT) 		5 GLY A 145
THR A 110
LEU A 185
GLN A 173
LEU A 142
 None
 1.44A 5fhzB-4bu0A:
undetectable		 5fhzB-4bu0A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8g 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Burkholderia
cenocepacia) 		PF02542
(YgbB) 		5 ILE A 118
GLY A  23
LEU A  42
ASN A 130
LEU A 107
 None
None
None
None
C5P  A1163 (-4.1A)
 1.37A 5fhzB-4c8gA:
undetectable		 5fhzB-4c8gA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8y CAS6A

(Thermus
thermophilus) 		PF10040
(CRISPR_Cas6) 		5 GLY A  47
LEU A  46
GLN A  95
LEU A   8
LEU A  84
 None
 1.39A 5fhzB-4c8yA:
undetectable		 5fhzB-4c8yA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3s IMINE REDUCTASE

(Nocardiopsis
halophila) 		PF03446
(NAD_binding_2) 		5 GLY A  20
LEU A  13
ASN A  96
LEU A  97
LEU A 157
 None
 1.08A 5fhzB-4d3sA:
undetectable		 5fhzB-4d3sA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6l AUSA REDUCTASE
DOMAIN PROTEIN

(Staphylococcus
aureus) 		no annotation 5 ILE B2130
GLY B2051
THR B2053
GLN B2289
LEU B2087
 None
 1.35A 5fhzB-4f6lB:
3.8		 5fhzB-4f6lB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE B 210
GLY B 206
LEU B 255
TRP B 203
ASN B 219
 None
 1.41A 5fhzB-4fzdB:
undetectable		 5fhzB-4fzdB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4

(Saccharopolyspora
spinosa) 		PF08659
(KR) 		5 ILE A 111
GLY A 241
LEU A 244
LEU A 102
LEU A 228
 None
 1.22A 5fhzB-4impA:
4.8		 5fhzB-4impA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j16 NAD/NADP
TRANSHYDROGENASE
ALPHA SUBUNIT 1

(Thermus
thermophilus) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 THR A 279
GLN A 257
ASN A 291
LEU A 267
LEU A 275
 None
NAD  A 500 (-4.7A)
None
None
None
 1.37A 5fhzB-4j16A:
3.4		 5fhzB-4j16A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		5 ILE A 528
GLY A 530
THR A 629
LEU A 636
LEU A 633
 None
 1.27A 5fhzB-4ncnA:
undetectable		 5fhzB-4ncnA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nu7 RIBULOSE-PHOSPHATE
3-EPIMERASE

(Toxoplasma
gondii) 		PF00834
(Ribul_P_3_epim) 		5 THR A 189
LEU A 164
GLN A   4
ASN A 199
LEU A 185
 None
 1.34A 5fhzB-4nu7A:
undetectable		 5fhzB-4nu7A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei) 		PF02608
(Bmp) 		5 ILE A  38
THR A 266
TRP A 136
ASN A  50
LEU A 286
 None
None
None
BR  A 418 (-3.6A)
None
 1.06A 5fhzB-4p98A:
3.8		 5fhzB-4p98A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei) 		PF02608
(Bmp) 		5 THR A 266
TRP A 136
GLN A  43
ASN A  50
LEU A 286
 None
None
None
BR  A 418 (-3.6A)
None
 1.16A 5fhzB-4p98A:
3.8		 5fhzB-4p98A:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pxn UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00171
(Aldedh) 		5 ILE A  88
LEU A 180
TRP A  73
ASN A 212
LEU A 214
 None
 1.40A 5fhzB-4pxnA:
48.5		 5fhzB-4pxnA:
32.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)

(Agrobacterium
fabrum) 		PF01547
(SBP_bac_1) 		5 ILE A 267
GLY A 263
THR A 143
LEU A 334
LEU A 361
 None
 1.41A 5fhzB-4rjzA:
undetectable		 5fhzB-4rjzA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmz EIF5B

(Chaetomium
thermophilum) 		no annotation 5 ILE B 528
GLY B 530
THR B 629
LEU B 636
LEU B 633
 None
 1.35A 5fhzB-4tmzB:
undetectable		 5fhzB-4tmzB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u39 CELL DIVISION
PROTEIN FTSZ

(Bacillus
subtilis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 ILE A 311
GLN A 192
ASN A 263
LEU A 200
LEU A 209
 None
 1.46A 5fhzB-4u39A:
3.0		 5fhzB-4u39A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		5 ILE A 338
GLY A 119
THR A 121
GLN A 415
LEU A  59
 None
 1.45A 5fhzB-4v1yA:
undetectable		 5fhzB-4v1yA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgk NEUTRAL CERAMIDASE

(Homo sapiens) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		5 ILE A 597
GLY A 509
TRP A 517
LEU A 506
LEU A 488
 None
 1.33A 5fhzB-4wgkA:
undetectable		 5fhzB-4wgkA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru HEN1

(Capnocytophaga
gingivalis) 		no annotation 5 ILE C 340
THR C 295
LEU C 351
GLN C 429
LEU C 268
 None
SAH  C 501 ( 4.4A)
SAH  C 501 (-4.3A)
PO4  C 503 ( 4.8A)
None
 1.23A 5fhzB-4xruC:
3.0		 5fhzB-4xruC:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 GLY A 595
THR A 569
TRP A 596
GLN A 168
ASN A 220
 None
 1.17A 5fhzB-4yzwA:
undetectable		 5fhzB-4yzwA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Streptobacillus
moniliformis) 		PF13407
(Peripla_BP_4) 		5 GLY A  30
THR A  32
LEU A  88
ASN A  82
LEU A  73
 None
NA  A 409 (-3.5A)
None
None
NA  A 409 ( 4.1A)
 1.19A 5fhzB-4z0nA:
2.1		 5fhzB-4z0nA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu9 ELONGATION FACTOR
SELB

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF09107
(SelB-wing_3) 		5 GLY A 335
THR A 276
ASN A 331
LEU A 333
LEU A 280
 None
 1.33A 5fhzB-4zu9A:
2.5		 5fhzB-4zu9A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a35 GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Streptococcus
pyogenes) 		PF01597
(GCV_H) 		5 ILE A  19
THR A  38
LEU A  43
ASN A   6
LEU A  62
 None
 1.14A 5fhzB-5a35A:
undetectable		 5fhzB-5a35A:
11.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		6 GLY A 124
THR A 128
LEU A 173
TRP A 177
GLN A 292
LEU A 477
 None
 0.86A 5fhzB-5abmA:
59.3		 5fhzB-5abmA:
68.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		5 ILE A 129
GLY A 131
THR A 496
GLN A 124
LEU A 239
 None
 1.42A 5fhzB-5aeeA:
undetectable		 5fhzB-5aeeA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5but KTR SYSTEM POTASSIUM
UPTAKE PROTEIN B

(Bacillus
subtilis) 		PF02386
(TrkH) 		5 ILE I  48
THR I 372
GLN I  71
LEU I 401
LEU I 369
 None
 1.25A 5fhzB-5butI:
undetectable		 5fhzB-5butI:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfn STIMULATOR OF
INTERFERON GENES

(Nematostella
vectensis) 		PF15009
(TMEM173) 		5 ILE A 236
TRP A 244
GLN A 336
LEU A 305
LEU A 306
 None
 1.43A 5fhzB-5cfnA:
undetectable		 5fhzB-5cfnA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fya PATATIN-LIKE
PROTEIN, PLPD

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		5 ILE A 294
GLY A 297
THR A 301
LEU A  43
LEU A  46
 None
 1.45A 5fhzB-5fyaA:
2.6		 5fhzB-5fyaA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj4 SERINE PROTEASE NS3

(Zika virus) 		PF00949
(Peptidase_S7) 		5 ILE B 147
TRP B  83
GLN B  96
LEU B 149
LEU B  76
 None
 1.33A 5fhzB-5gj4B:
undetectable		 5fhzB-5gj4B:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxj FLAVIVIRUS_NS2B,LINK
ER,PEPTIDASE S7

(Zika virus;
synthetic
construct) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		5 ILE A1147
TRP A1083
GLN A1096
LEU A1149
LEU A1076
 None
 1.12A 5fhzB-5gxjA:
undetectable		 5fhzB-5gxjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF11864
(DUF3384) 		5 ILE A 153
THR A 193
GLN A 146
LEU A 186
LEU A 257
 ILE  A 153 ( 0.6A)
THR  A 193 ( 0.8A)
GLN  A 146 ( 0.6A)
LEU  A 186 ( 0.5A)
LEU  A 257 ( 0.6A)
 1.37A 5fhzB-5hiuA:
undetectable		 5fhzB-5hiuA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hra ASPARTATE/GLUTAMATE
RACEMASE

(Escherichia
coli) 		PF01177
(Asp_Glu_race) 		5 ILE A  48
GLY A   9
THR A  15
LEU A   7
LEU A  40
 None
 1.48A 5fhzB-5hraA:
undetectable		 5fhzB-5hraA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nhs BIFUNCTIONAL PROTEIN
FOLD

(Xanthomonas
albilineans) 		no annotation 5 ILE A  20
GLY A 154
LEU A 147
LEU A 159
LEU A 188
 None
 1.11A 5fhzB-5nhsA:
2.4		 5fhzB-5nhsA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1v NS2B-NS3
PROTEASE,NS2B-NS3
PROTEASE

(Zika virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		5 ILE A 212
TRP A 148
GLN A 161
LEU A 214
LEU A 141
 None
 1.29A 5fhzB-5t1vA:
undetectable		 5fhzB-5t1vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 5 ILE A1158
GLY A 983
LEU A 982
ASN A1022
LEU A 989
 None
 1.34A 5fhzB-5wnoA:
undetectable		 5fhzB-5wnoA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Pseudomonas
aeruginosa) 		no annotation 5 GLY A 219
THR A 221
LEU A 242
LEU A 214
LEU A 180
 None
 1.14A 5fhzB-5wyrA:
undetectable		 5fhzB-5wyrA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A 419
GLY A 421
THR A 423
LEU A 433
LEU A 429
 None
 1.34A 5fhzB-6az0A:
undetectable		 5fhzB-6az0A:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b5i RETINAL
DEHYDROGENASE 2

(Homo sapiens) 		no annotation 7 GLY A 142
THR A 146
LEU A 191
TRP A 195
GLN A 310
ASN A 475
LEU A 477
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.4A)
None
CU4  A 601 (-4.2A)
CU4  A 601 (-3.6A)
CU4  A 601 (-3.7A)
CU4  A 601 (-3.8A)
 0.71A 5fhzB-6b5iA:
59.6		 5fhzB-6b5iA:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b5i RETINAL
DEHYDROGENASE 2

(Homo sapiens) 		no annotation 6 GLY A 142
THR A 146
TRP A 195
GLN A 307
ASN A 475
LEU A 477
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.4A)
CU4  A 601 (-4.2A)
None
CU4  A 601 (-3.7A)
CU4  A 601 (-3.8A)
 1.43A 5fhzB-6b5iA:
59.6		 5fhzB-6b5iA:
63.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbj TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4

(Xenopus
tropicalis) 		no annotation 5 ILE A 541
GLY A 591
ASN A 537
LEU A 539
LEU A 594
 None
 1.47A 5fhzB-6bbjA:
undetectable		 5fhzB-6bbjA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch0 -

(-) 		no annotation 5 ILE C 159
GLY C 125
THR C  66
GLN C 153
LEU C 119
 None
 1.38A 5fhzB-6ch0C:
undetectable		 5fhzB-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 5 GLY A 563
GLN A 588
ASN A 590
LEU A 593
LEU A 625
 None
 1.25A 5fhzB-6f2tA:
undetectable		 5fhzB-6f2tA:
undetectable