SIMILAR PATTERNS OF AMINO ACIDS FOR 5FHZ_A_REAA602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00274
(Glycolytic) 		5 ILE A 320
GLY A 324
ASN A  60
PHE A  53
LEU A  58
 None
 1.41A 5fhzA-1f2jA:
undetectable		 5fhzA-1f2jA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1grj GREA PROTEIN

(Escherichia
coli) 		PF01272
(GreA_GreB)
PF03449
(GreA_GreB_N) 		5 ILE A 126
GLY A 129
ARG A 128
ASN A  96
PHE A 150
 None
 1.35A 5fhzA-1grjA:
undetectable		 5fhzA-1grjA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kut PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Thermotoga
maritima) 		PF01259
(SAICAR_synt) 		5 ARG A 193
PHE A 159
LEU A 166
CYH A 224
THR A  46
 None
 1.33A 5fhzA-1kutA:
undetectable		 5fhzA-1kutA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		5 GLY A 109
ARG A 110
ASN A 151
LEU A 106
THR A 154
 CL  A 182 (-3.2A)
None
None
None
None
 1.41A 5fhzA-1ufrA:
undetectable		 5fhzA-1ufrA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA

(Escherichia
coli) 		PF01938
(TRAM)
PF05958
(tRNA_U5-meth_tr) 		5 GLY A 190
ARG A 206
LEU A 135
MET A 146
CYH A 179
 None
PO4  A1435 (-4.2A)
None
None
None
 1.18A 5fhzA-1uwvA:
2.3		 5fhzA-1uwvA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2b PROLINE
IMINOPEPTIDASE

(Serratia
marcescens) 		PF00561
(Abhydrolase_1) 		5 GLY A 240
THR A  88
ASN A 275
LEU A 141
CYH A 271
 None
None
None
None
STX  A 401 ( 4.9A)
 1.44A 5fhzA-1x2bA:
undetectable		 5fhzA-1x2bA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzn PYRR BIFUNCTIONAL
PROTEIN

([Bacillus]
caldolyticus) 		PF00156
(Pribosyltran) 		5 GLY A 110
ARG A 111
ASN A 152
LEU A 107
THR A 155
 SO4  A 301 (-3.6A)
None
None
None
None
 1.38A 5fhzA-1xznA:
undetectable		 5fhzA-1xznA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2

(Homo sapiens) 		PF00632
(HECT) 		5 GLY A 502
ARG A 680
PHE A 457
LEU A 450
MET A 449
 None
 1.40A 5fhzA-1zvdA:
undetectable		 5fhzA-1zvdA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb3 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-LE

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		5 GLY A 253
ARG A 254
ASN A 218
LEU A 243
THR A 209
 None
MLD  A1345 (-3.0A)
None
None
None
 1.42A 5fhzA-2cb3A:
undetectable		 5fhzA-2cb3A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		5 GLY A 379
THR A 399
ASN A 263
PHE A 388
LEU A 387
 None
 1.22A 5fhzA-2fj0A:
undetectable		 5fhzA-2fj0A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hhi IMMUNOGENIC PROTEIN
MPT64

(Mycobacterium
tuberculosis) 		PF11738
(DUF3298) 		5 ILE A 201
GLY A 174
ARG A 198
THR A 171
PHE A 177
 None
 1.47A 5fhzA-2hhiA:
undetectable		 5fhzA-2hhiA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg7 ANTIQUITIN

(Acanthopagrus
schlegelii) 		PF00171
(Aldedh) 		5 ASN A 166
PHE A 167
TRP A 174
CYH A 301
THR A 302
 NAD  A1510 (-3.2A)
None
None
NAD  A1510 (-3.0A)
None
 0.78A 5fhzA-2jg7A:
48.2		 5fhzA-2jg7A:
29.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg7 ANTIQUITIN

(Acanthopagrus
schlegelii) 		PF00171
(Aldedh) 		5 GLY A 116
ASN A 166
PHE A 167
CYH A 301
THR A 302
 None
NAD  A1510 (-3.2A)
None
NAD  A1510 (-3.0A)
None
 1.34A 5fhzA-2jg7A:
48.2		 5fhzA-2jg7A:
29.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phl PHASEOLIN

(Phaseolus
vulgaris) 		PF00190
(Cupin_1) 		5 ILE A 369
GLY A 345
ARG A 346
PHE A 358
LEU A 354
 None
 1.24A 5fhzA-2phlA:
undetectable		 5fhzA-2phlA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00171
(Aldedh) 		5 GLY A 104
THR A 108
TRP A 163
CYH A 296
THR A 297
 ETE  A1524 (-3.5A)
None
ETE  A1524 (-3.9A)
None
ETE  A1524 ( 4.1A)
 1.11A 5fhzA-2vroA:
42.3		 5fhzA-2vroA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 5 GLY A  37
THR A  33
ASN A  58
LEU A  68
THR A 727
 None
 1.49A 5fhzA-3a0fA:
undetectable		 5fhzA-3a0fA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR

(Pyrococcus
furiosus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 GLY B 215
ARG B 163
THR B 213
LEU B 223
MET B 224
 None
PO4  B 323 ( 2.9A)
None
None
None
 1.41A 5fhzA-3dm9B:
undetectable		 5fhzA-3dm9B:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftt PUTATIVE
ACETYLTRANSFERASE
SACOL2570

(Staphylococcus
aureus) 		PF00132
(Hexapep)
PF12464
(Mac)
PF14602
(Hexapep_2) 		5 ILE A 151
GLY A 134
PHE A 109
CYH A 107
CYH A  87
 None
 1.48A 5fhzA-3fttA:
undetectable		 5fhzA-3fttA:
15.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iwj PUTATIVE
AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		5 ASN A 162
LEU A 166
MET A 167
TRP A 170
CYH A 294
 GOL  A 507 (-4.4A)
None
GOL  A 507 ( 4.0A)
None
GOL  A 507 (-3.4A)
 0.89A 5fhzA-3iwjA:
56.1		 5fhzA-3iwjA:
40.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iwj PUTATIVE
AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		5 THR A 455
ASN A 162
LEU A 166
MET A 167
TRP A 170
 None
GOL  A 507 (-4.4A)
None
GOL  A 507 ( 4.0A)
None
 1.45A 5fhzA-3iwjA:
56.1		 5fhzA-3iwjA:
40.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08454
(RIH_assoc)
PF08709
(Ins145_P3_rec) 		5 GLY A 268
ARG A 269
THR A 276
PHE A 263
LEU A 264
 None
 1.38A 5fhzA-3javA:
undetectable		 5fhzA-3javA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3l CYTOCHROME P450

(Streptomyces
thioluteus) 		PF00067
(p450) 		5 GLY A  67
ARG A 296
LEU A  71
MET A  74
THR A  43
 None
HEM  A 501 (-2.9A)
None
None
None
 1.39A 5fhzA-3p3lA:
undetectable		 5fhzA-3p3lA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3q SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE

(Saccharomyces
cerevisiae) 		PF05743
(UEV) 		5 ILE A  69
GLY A  67
ASN A  41
PHE A  42
LEU A  45
 None
 1.22A 5fhzA-3r3qA:
undetectable		 5fhzA-3r3qA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 GLY N 141
PHE N 105
LEU N 108
CYH N  88
THR N  87
 None
 1.39A 5fhzA-3rkoN:
undetectable		 5fhzA-3rkoN:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlz MCCF

(Escherichia
coli) 		PF02016
(Peptidase_S66) 		5 ILE A 215
GLY A 217
THR A 121
ASN A 262
LEU A 222
 None
None
None
EDO  A 346 ( 4.7A)
None
 1.48A 5fhzA-3tlzA:
undetectable		 5fhzA-3tlzA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukm POTASSIUM CHANNEL
SUBFAMILY K MEMBER 1

(Homo sapiens) 		PF07885
(Ion_trans_2) 		5 ILE A 249
GLY A 234
ARG A 242
PHE A 218
THR A 118
 None
 1.41A 5fhzA-3ukmA:
undetectable		 5fhzA-3ukmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		5 ILE A 311
GLY A 559
THR A 562
ASN A 525
PHE A 555
 None
 1.49A 5fhzA-3welA:
undetectable		 5fhzA-3welA:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a0m BETAINE ALDEHYDE
DEHYDROGENASE,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00171
(Aldedh) 		5 ASN A 159
LEU A 163
MET A 164
TRP A 167
CYH A 291
 NAD  A1498 (-3.5A)
None
NAD  A1498 ( 3.9A)
None
NAD  A1498 (-3.3A)
 0.57A 5fhzA-4a0mA:
57.5		 5fhzA-4a0mA:
41.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT
HYDROGENASE-1 SMALL
SUBUNIT

(Salmonella
enterica) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 ILE A  88
GLY A 235
ASN A 231
LEU A 233
TRP B 205
 None
 1.49A 5fhzA-4c3oA:
undetectable		 5fhzA-4c3oA:
22.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dal PUTATIVE ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 ASN A 149
MET A 154
TRP A 157
CYH A 280
THR A 281
 None
 0.53A 5fhzA-4dalA:
55.4		 5fhzA-4dalA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea mays) 		PF00171
(Aldedh) 		5 ASN A 164
LEU A 168
MET A 169
TRP A 172
CYH A 296
 NAD  A 601 (-3.2A)
None
NAD  A 601 ( 3.8A)
None
NAD  A 601 ( 2.7A)
 0.55A 5fhzA-4i8pA:
56.4		 5fhzA-4i8pA:
39.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		5 ASN A 162
LEU A 166
MET A 167
TRP A 170
CYH A 295
 NAD  A 601 (-3.3A)
None
NAD  A 601 ( 3.9A)
EDO  A 609 (-4.2A)
NAD  A 601 (-3.3A)
 0.53A 5fhzA-4i8qA:
52.6		 5fhzA-4i8qA:
37.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		6 ASN A 169
PHE A 170
LEU A 173
MET A 174
CYH A 301
CYH A 302
 None
2AK  A 601 (-4.1A)
2AK  A 601 (-4.9A)
2AK  A 601 ( 3.9A)
2AK  A 601 (-2.8A)
2AK  A 601 (-4.6A)
 0.91A 5fhzA-4kwgA:
60.2		 5fhzA-4kwgA:
63.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		6 ASN A 169
PHE A 170
LEU A 173
MET A 174
TRP A 177
CYH A 301
 None
2AK  A 601 (-4.1A)
2AK  A 601 (-4.9A)
2AK  A 601 ( 3.9A)
None
2AK  A 601 (-2.8A)
 0.59A 5fhzA-4kwgA:
60.2		 5fhzA-4kwgA:
63.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 ASN A 168
PHE A 169
LEU A 172
MET A 173
CYH A 301
 MES  A 501 (-3.6A)
MES  A 501 (-3.8A)
None
MES  A 501 ( 4.1A)
MES  A 501 (-3.7A)
 0.88A 5fhzA-4lihA:
58.1		 5fhzA-4lihA:
39.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		7 GLY A 123
ASN A 168
PHE A 169
LEU A 172
MET A 173
TRP A 176
THR A 302
 None
MES  A 501 (-3.6A)
MES  A 501 (-3.8A)
None
MES  A 501 ( 4.1A)
None
MES  A 501 (-3.0A)
 0.69A 5fhzA-4lihA:
58.1		 5fhzA-4lihA:
39.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01425
(Amidase) 		5 ILE A 180
ARG A 176
THR A 151
PHE A 100
MET A 102
 None
None
GLN  A 501 (-4.4A)
None
None
 1.22A 5fhzA-4n0iA:
undetectable		 5fhzA-4n0iA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 1

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A 305
LEU A 189
MET A 206
CYH A 146
THR A 145
 SCY  A 112 ( 3.8A)
COA  A 401 (-4.2A)
COA  A 401 (-3.8A)
None
None
 1.45A 5fhzA-4nhdA:
undetectable		 5fhzA-4nhdA:
21.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o5h PHENYLACETALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		6 ASN A 177
PHE A 178
LEU A 181
MET A 182
TRP A 185
CYH A 309
 None
 0.79A 5fhzA-4o5hA:
54.1		 5fhzA-4o5hA:
44.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o5h PHENYLACETALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		6 ASN A 177
PHE A 178
LEU A 181
MET A 182
TRP A 185
THR A 310
 None
 0.61A 5fhzA-4o5hA:
54.1		 5fhzA-4o5hA:
44.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 ILE A 124
GLY A 120
ASN A 154
PHE A 183
THR A  21
 None
 1.34A 5fhzA-4qmeA:
undetectable		 5fhzA-4qmeA:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qyj ALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 ASN A 169
MET A 174
TRP A 177
CYH A 301
THR A 302
 None
 0.71A 5fhzA-4qyjA:
53.5		 5fhzA-4qyjA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qyj ALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		6 ASN A 169
PHE A 170
LEU A 173
MET A 174
TRP A 177
CYH A 301
 None
 0.63A 5fhzA-4qyjA:
53.5		 5fhzA-4qyjA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		8 GLY A 124
THR A 128
ASN A 169
PHE A 170
LEU A 173
TRP A 177
CYH A 301
CYH A 302
 None
None
TXE  A 501 (-3.5A)
None
None
None
None
TXE  A 501 (-4.4A)
 0.64A 5fhzA-5abmA:
62.2		 5fhzA-5abmA:
68.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		7 GLY A 124
THR A 128
PHE A 170
LEU A 173
MET A 174
CYH A 301
CYH A 302
 None
None
None
None
None
None
TXE  A 501 (-4.4A)
 0.94A 5fhzA-5abmA:
62.2		 5fhzA-5abmA:
68.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 ILE A 137
GLY A 133
ASN A 167
PHE A 196
THR A  28
 None
 1.34A 5fhzA-5dllA:
undetectable		 5fhzA-5dllA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du9 CDA PEPTIDE
SYNTHETASE I

(Streptomyces
coelicolor) 		PF00668
(Condensation) 		5 GLY A 154
ARG A  32
THR A  33
PHE A 168
THR A  59
 None
 1.43A 5fhzA-5du9A:
undetectable		 5fhzA-5du9A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iao BIFUNCTIONAL PROTEIN
PYRR

(Mycobacterium
tuberculosis) 		PF00156
(Pribosyltran) 		5 GLY A 125
ARG A 126
ASN A 167
LEU A 122
THR A 170
 None
 1.37A 5fhzA-5iaoA:
undetectable		 5fhzA-5iaoA:
17.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 7 GLY A 123
ASN A 168
PHE A 169
MET A 173
TRP A 176
CYH A 302
THR A 303
 None
NAD  A 700 ( 3.0A)
IAC  A 701 (-3.7A)
NAD  A 700 (-3.9A)
None
IAC  A 701 ( 2.8A)
IAC  A 701 ( 4.2A)
 0.61A 5fhzA-5iuwA:
56.4		 5fhzA-5iuwA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 GLY A 124
ASN A 168
PHE A 169
TRP A 176
CYH A 302
 None
NAD  A 700 ( 3.0A)
IAC  A 701 (-3.7A)
None
IAC  A 701 ( 2.8A)
 1.11A 5fhzA-5iuwA:
56.4		 5fhzA-5iuwA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))

(Thermoplasma
acidophilum) 		PF00171
(Aldedh) 		5 GLY A 103
ASN A 149
PHE A 150
MET A 154
CYH A 281
 None
 0.75A 5fhzA-5izdA:
54.5		 5fhzA-5izdA:
31.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9h ENVELOPMENT
POLYPROTEIN

(Puumala
orthohantavirus) 		PF01561
(Hanta_G2) 		5 ILE A 763
GLY A 791
THR A 741
PHE A 915
LEU A 739
 None
 1.18A 5fhzA-5j9hA:
undetectable		 5fhzA-5j9hA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		5 ILE A 573
ARG A 602
PHE A 562
LEU A 510
CYH A 534
 None
 1.29A 5fhzA-5jxrA:
undetectable		 5fhzA-5jxrA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 5 GLY A 710
ARG A 711
THR A 712
ASN A 208
PHE A 687
 None
 1.39A 5fhzA-5mzsA:
undetectable		 5fhzA-5mzsA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B

(Methanothermobacter
sp. CaT2) 		PF00384
(Molybdopterin) 		5 ILE B 270
ARG B 214
PHE B 252
LEU B 250
THR B 257
 None
 1.37A 5fhzA-5t5iB:
2.1		 5fhzA-5t5iB:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE

(Cupriavidus
necator) 		PF07167
(PhaC_N) 		5 ILE A 513
GLY A 511
ARG A 521
PHE A 318
THR A 393
 None
 1.40A 5fhzA-5t6oA:
undetectable		 5fhzA-5t6oA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 5 GLY A 411
ARG A 412
THR A 735
LEU A  32
CYH A  36
 None
 1.48A 5fhzA-5vm9A:
undetectable		 5fhzA-5vm9A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		5 ARG A 574
THR A 568
PHE C 118
LEU C 114
THR D 467
 None
 1.47A 5fhzA-5xfaA:
3.0		 5fhzA-5xfaA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S8

(Trichomonas
vaginalis) 		PF01201
(Ribosomal_S8e) 		5 ILE I 166
GLY I  63
THR I  76
ASN I  94
THR I  82
 None
 1.46A 5fhzA-5xyiI:
undetectable		 5fhzA-5xyiI:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF

(Caldanaerobacter
subterraneus) 		no annotation 5 GLY A  72
ARG A  71
ASN A  26
PHE A  21
LEU A   3
 None
 1.23A 5fhzA-5z67A:
undetectable		 5fhzA-5z67A:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao8 ARGININE--TRNA
LIGASE

(Neisseria
gonorrhoeae) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 ILE A 566
GLY A 560
THR A 556
ASN A 454
LEU A 519
 None
 1.32A 5fhzA-6ao8A:
2.8		 5fhzA-6ao8A:
26.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b5i RETINAL
DEHYDROGENASE 2

(Homo sapiens) 		no annotation 9 GLY A 142
THR A 146
ASN A 187
PHE A 188
LEU A 191
MET A 192
CYH A 319
CYH A 320
THR A 321
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.4A)
CU4  A 601 (-4.2A)
CU4  A 601 (-3.6A)
None
CU4  A 601 ( 4.7A)
CU4  A 601 ( 4.5A)
CU4  A 601 (-4.2A)
CU4  A 601 (-3.0A)
 0.78A 5fhzA-6b5iA:
62.8		 5fhzA-6b5iA:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b5i RETINAL
DEHYDROGENASE 2

(Homo sapiens) 		no annotation 9 GLY A 142
THR A 146
ASN A 187
PHE A 188
LEU A 191
MET A 192
TRP A 195
CYH A 319
THR A 321
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.4A)
CU4  A 601 (-4.2A)
CU4  A 601 (-3.6A)
None
CU4  A 601 ( 4.7A)
CU4  A 601 (-4.2A)
CU4  A 601 ( 4.5A)
CU4  A 601 (-3.0A)
 0.71A 5fhzA-6b5iA:
62.8		 5fhzA-6b5iA:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b5i RETINAL
DEHYDROGENASE 2

(Homo sapiens) 		no annotation 6 GLY A 142
THR A 146
ASN A 315
LEU A 191
TRP A 195
THR A 321
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.4A)
None
None
CU4  A 601 (-4.2A)
CU4  A 601 (-3.0A)
 1.46A 5fhzA-6b5iA:
62.8		 5fhzA-6b5iA:
63.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE

(Salmonella
enterica) 		no annotation 5 ASN A 149
MET A 154
TRP A 157
CYH A 280
THR A 281
 None
 0.82A 5fhzA-6c43A:
57.3		 5fhzA-6c43A:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccb GLYCOPROTEIN 120
GLYCOPROTEIN 41

(Human
immunodeficiency
virus 1) 		no annotation 5 GLY A 572
ARG A 567
THR A 569
PHE C  53
TRP A 571
 None
 1.46A 5fhzA-6ccbA:
undetectable		 5fhzA-6ccbA:
9.80