SIMILAR PATTERNS OF AMINO ACIDS FOR 5FHR_B_SAMB303

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)

(Planomicrobium
okeanokoites) 		PF02980
(FokI_C)
PF02981
(FokI_N)
PF09254
(Endonuc-FokI_C)
PF16902
(Type2_restr_D3) 		5 MET A 433
GLY A 451
TYR A 436
TYR A 454
HIS A 442
 None
 1.37A 5fhrB-1fokA:
1.4		 5fhrB-1fokA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		6 MET A  61
GLU A  85
GLY A  87
TYR A  89
TYR A  92
ASN A 113
 SPF  A 401 (-4.1A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.7A)
None
None
 0.76A 5fhrB-1susA:
17.6		 5fhrB-1susA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akf PUTATIVE SECRETED
ALPHA
L-ARABINOFURANOSIDAS
E II

(Streptomyces
avermitilis) 		PF04616
(Glyco_hydro_43)
PF05270
(AbfB) 		5 ASN A 422
GLU A 419
GLY A 425
TYR A 423
TYR A 421
 None
 1.42A 5fhrB-3akfA:
undetectable		 5fhrB-3akfA:
19.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bwm CATECHOL
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		10 MET A  40
ASN A  41
VAL A  42
GLU A  64
GLY A  66
TYR A  68
TYR A  71
ASN A  92
HIS A 142
TRP A 143
 SAM  A 301 (-3.7A)
SAM  A 301 (-4.7A)
SAM  A 301 ( 3.7A)
SAM  A 301 ( 4.1A)
SAM  A 301 (-3.2A)
SAM  A 301 (-4.7A)
None
None
SAM  A 301 ( 4.9A)
SAM  A 301 ( 3.4A)
 0.22A 5fhrB-3bwmA:
34.3		 5fhrB-3bwmA:
80.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE

(Oenococcus oeni) 		PF12697
(Abhydrolase_6) 		5 VAL A 219
GLY A 243
TYR A 221
ASN A 240
HIS A 133
 None
 1.36A 5fhrB-3fsgA:
2.8		 5fhrB-3fsgA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv1 POLAR AMINO ACID ABC
UPTAKE TRANSPORTER
SUBSTRATE BINDING
PROTEIN

(Streptococcus
thermophilus) 		PF00497
(SBP_bac_3) 		5 VAL A 207
GLU A 232
GLY A 231
TYR A 208
TYR A 229
 None
 1.38A 5fhrB-3hv1A:
undetectable		 5fhrB-3hv1A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njx RHAMNOGALACTURONASE
B

(Aspergillus
aculeatus) 		PF09284
(RhgB_N)
PF14683
(CBM-like)
PF14686
(fn3_3) 		5 ASN A 207
GLU A 214
GLY A 185
TYR A 216
TYR A 179
 None
 1.50A 5fhrB-3njxA:
undetectable		 5fhrB-3njxA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntv MW1564 PROTEIN

(Staphylococcus
aureus) 		PF01596
(Methyltransf_3) 		5 VAL A  55
GLU A  77
GLY A  79
TYR A  84
ASN A 104
 SO4  A 233 (-4.2A)
SO4  A 233 (-4.0A)
None
SO4  A 233 (-4.9A)
None
 0.48A 5fhrB-3ntvA:
18.8		 5fhrB-3ntvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l39 4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12

(Arabidopsis
thaliana) 		PF03321
(GH3) 		5 VAL A 345
GLY A 404
TYR A 347
ASN A 407
TYR A 406
 None
None
APC  A 603 (-4.4A)
None
None
 1.44A 5fhrB-4l39A:
2.3		 5fhrB-4l39A:
17.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		6 GLU A 107
GLY A 109
TYR A 114
ASN A 135
TYR A 138
HIS A 185
 None
2F6  A 301 (-3.6A)
None
None
None
None
 0.37A 5fhrB-4p58A:
29.5		 5fhrB-4p58A:
97.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 ASN A 159
GLY A 113
TYR A 115
ASN A 362
TYR A 134
 None
 1.50A 5fhrB-5dmyA:
2.0		 5fhrB-5dmyA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kva CAFFEOYL-COA
O-METHYLTRANSFERASE

(Sorghum bicolor) 		PF01596
(Methyltransf_3) 		5 GLU A  99
GLY A 101
TYR A 103
TYR A 106
ASN A 127
 SAM  A 301 ( 4.0A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.8A)
None
None
 0.52A 5fhrB-5kvaA:
17.7		 5fhrB-5kvaA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kva CAFFEOYL-COA
O-METHYLTRANSFERASE

(Sorghum bicolor) 		PF01596
(Methyltransf_3) 		5 MET A  75
GLU A  99
GLY A 101
TYR A 103
ASN A 127
 SAM  A 301 (-3.8A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.8A)
None
 0.51A 5fhrB-5kvaA:
17.7		 5fhrB-5kvaA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 5 ASN A 163
GLY A 117
TYR A 119
ASN A 359
TYR A 138
 None
 1.48A 5fhrB-6b6lA:
undetectable		 5fhrB-6b6lA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amo NADPH-CYTOCHROME
P450 REDUCTASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 SER A 310
SER A 460
GLN A 545
ASP A 306
 None
 1.42A 5fhrB-1amoA:
3.8		 5fhrB-1amoA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N) 		4 GLU A  88
SER A 100
GLN A 101
ASP A  81
 None
 1.22A 5fhrB-1fi4A:
undetectable		 5fhrB-1fi4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtm GLUTAMATE
DEHYDROGENASE

(Pyrococcus
furiosus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 SER A 195
GLU A 188
GLN A 357
ASP A 374
 None
 1.41A 5fhrB-1gtmA:
3.1		 5fhrB-1gtmA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4z ADENYLYL
CYCLASE-ASSOCIATED
PROTEIN

(Saccharomyces
cerevisiae) 		PF08603
(CAP_C) 		4 SER A1484
SER A1427
GLN A1408
ASP A1464
 None
 1.50A 5fhrB-1k4zA:
undetectable		 5fhrB-1k4zA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfe HYPOTHETICAL PROTEIN
RV2991

(Mycobacterium
tuberculosis) 		PF01243
(Putative_PNPOx) 		4 SER A  22
SER A 144
GLN A   5
ASP A  18
 None
 1.40A 5fhrB-1rfeA:
undetectable		 5fhrB-1rfeA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg1 TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER
16

(Rattus
norvegicus) 		PF00020
(TNFR_c6) 		4 SER X 127
SER X 109
GLN X 111
ASP X 134
 None
 1.40A 5fhrB-1sg1X:
undetectable		 5fhrB-1sg1X:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 SER A  52
GLU A  58
SER A 591
GLN A 580
 None
 1.40A 5fhrB-1xc6A:
undetectable		 5fhrB-1xc6A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw1 PROTEIN YTNJ

(Bacillus
subtilis) 		PF00296
(Bac_luciferase) 		4 SER A 207
GLU A 424
SER A  52
GLN A   8
 None
 1.47A 5fhrB-1yw1A:
undetectable		 5fhrB-1yw1A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 SER A 684
SER A 673
GLN A 563
ASP A 857
 None
 1.39A 5fhrB-2inyA:
undetectable		 5fhrB-2inyA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqp LARGE CAPSID PROTEIN

(Providence
virus) 		PF03566
(Peptidase_A21) 		4 SER A 435
GLU A 428
GLN A 544
ASP A 555
 None
 1.12A 5fhrB-2qqpA:
undetectable		 5fhrB-2qqpA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whl BETA-MANNANASE

(Salipaludibacillus
agaradhaerens) 		PF00150
(Cellulase) 		4 SER A 266
GLU A  45
SER A  37
ASP A 268
 None
 1.29A 5fhrB-2whlA:
undetectable		 5fhrB-2whlA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeb SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
CYTOCHROME B SMALL
SUBUNIT,
MITOCHONDRIAL

(Sus scrofa;
Sus scrofa;
Sus scrofa) 		PF13085
(Fer2_3)
PF13534
(Fer4_17)
PF01127
(Sdh_cyt)
PF05328
(CybS) 		4 GLU D  46
SER D  40
GLN B 207
ASP C 112
 None
 1.47A 5fhrB-3aebD:
undetectable		 5fhrB-3aebD:
24.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bwm CATECHOL
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		5 SER A  72
GLU A  90
SER A 119
GLN A 120
ASP A 141
 SAM  A 301 (-2.9A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.6A)
MG  A 300 (-2.4A)
 0.24A 5fhrB-3bwmA:
34.3		 5fhrB-3bwmA:
80.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3by9 SENSOR PROTEIN

(Vibrio cholerae) 		PF02743
(dCache_1) 		4 SER A  46
GLU A 248
GLN A  32
ASP A  43
 None
 1.18A 5fhrB-3by9A:
undetectable		 5fhrB-3by9A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ds8 LIN2722 PROTEIN

(Listeria
innocua) 		PF06028
(DUF915) 		4 SER A 195
SER A  12
GLN A  70
ASP A 136
 None
SO4  A 255 ( 2.6A)
None
None
 1.42A 5fhrB-3ds8A:
2.8		 5fhrB-3ds8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn5 SORTASE A

(Streptococcus
pyogenes) 		PF04203
(Sortase) 		4 GLU A 202
SER A 138
GLN A 129
ASP A 192
 None
 1.45A 5fhrB-3fn5A:
undetectable		 5fhrB-3fn5A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib3 COCE/NOND FAMILY
HYDROLASE

(Staphylococcus
aureus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 SER A 136
GLU A 144
SER A 180
GLN A 257
 None
 1.24A 5fhrB-3ib3A:
2.3		 5fhrB-3ib3A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwe MGLL PROTEIN

(Homo sapiens) 		PF12146
(Hydrolase_4) 		4 SER A 156
GLU A 284
SER A 192
ASP A 249
 None
 1.49A 5fhrB-3jweA:
2.9		 5fhrB-3jweA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 SER A 756
SER A 583
GLN A 572
ASP A 774
 None
 1.35A 5fhrB-3k4xA:
undetectable		 5fhrB-3k4xA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kya PUTATIVE PHOSPHATASE

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		4 SER A  95
SER A 445
GLN A 451
ASP A 458
 EDO  A   2 ( 2.7A)
None
None
EDO  A   2 (-3.7A)
 1.21A 5fhrB-3kyaA:
undetectable		 5fhrB-3kyaA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA
NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum;
Allochromatium
vinosum) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
PF00374
(NiFeSe_Hases) 		4 SER A 204
GLU A 208
SER B1230
ASP A 206
 None
 1.36A 5fhrB-3myrA:
undetectable		 5fhrB-3myrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhe UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2

(Homo sapiens) 		PF00443
(UCH) 		4 SER A 421
SER A 442
GLN A 359
ASP A 436
 None
 1.32A 5fhrB-3nheA:
undetectable		 5fhrB-3nheA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqi GENE PRODUCT 138

(unidentified
phage) 		no annotation 4 SER A 151
SER A 174
GLN A 188
ASP A 153
 None
 1.49A 5fhrB-3pqiA:
undetectable		 5fhrB-3pqiA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF06824
(Glyco_hydro_125) 		4 SER A 348
GLU A 288
SER A 212
ASP A 219
 None
 1.39A 5fhrB-3qpfA:
undetectable		 5fhrB-3qpfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tek THERMODBP-SINGLE
STRANDED DNA BINDING
PROTEIN

(Thermoproteus
tenax) 		no annotation 4 SER A  63
GLU A  12
SER A 119
GLN A 139
 None
 1.34A 5fhrB-3tekA:
undetectable		 5fhrB-3tekA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6o DYNAMIN-1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 GLU A 729
SER A 724
GLN A 721
ASP A  13
 None
 1.48A 5fhrB-3w6oA:
0.8		 5fhrB-3w6oA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcy INTERFERON
ALPHA/BETA RECEPTOR
1

(Mus musculus) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		4 SER A 245
GLU A 106
SER A 103
ASP A 126
 None
 1.30A 5fhrB-3wcyA:
undetectable		 5fhrB-3wcyA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh9 ENDO-BETA-1,4-MANNAN
ASE

(Aspergillus
niger) 		PF00150
(Cellulase) 		4 SER A 313
SER A  96
GLN A  99
ASP A  32
 None
 1.49A 5fhrB-3wh9A:
undetectable		 5fhrB-3wh9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxj AMPDH3

(Pseudomonas
aeruginosa) 		PF01510
(Amidase_2) 		4 GLU A 165
SER A 119
GLN A  65
ASP A 115
 None
 1.39A 5fhrB-4bxjA:
undetectable		 5fhrB-4bxjA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		4 SER A 393
SER A 583
GLN A 586
ASP A 347
 None
GOL  A 701 ( 4.3A)
GOL  A 701 (-3.5A)
None
 1.47A 5fhrB-4dwsA:
undetectable		 5fhrB-4dwsA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		4 SER A 310
GLU A 323
SER A 295
GLN A 292
 EDO  A 503 (-3.0A)
None
None
None
 1.30A 5fhrB-4efcA:
undetectable		 5fhrB-4efcA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		4 SER A 258
SER A 296
GLN A 452
ASP A 471
 None
 1.36A 5fhrB-4i8qA:
4.2		 5fhrB-4i8qA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irt UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15892
(BNR_4) 		4 GLU A 414
SER A  31
GLN A 418
ASP A  60
 None
 1.36A 5fhrB-4irtA:
undetectable		 5fhrB-4irtA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1s POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		4 SER A 216
GLU A 288
SER A 273
GLN A 327
 None
 1.44A 5fhrB-4j1sA:
undetectable		 5fhrB-4j1sA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq3 CYANURIC ACID
AMIDOHYDROLASE

(Azorhizobium
caulinodans) 		PF09663
(Amido_AtzD_TrzD) 		4 SER A 308
GLU A 337
SER A 226
GLN A 154
 None
None
BR8  A 401 (-3.4A)
None
 1.48A 5fhrB-4nq3A:
undetectable		 5fhrB-4nq3A:
20.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		4 GLU A 133
SER A 162
GLN A 163
ASP A 184
 2F6  A 301 (-2.7A)
2F6  A 301 (-3.2A)
2F6  A 301 (-3.8A)
None
 0.41A 5fhrB-4p58A:
29.5		 5fhrB-4p58A:
97.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		4 SER A 115
GLU A 133
SER A 162
ASP A 184
 None
2F6  A 301 (-2.7A)
2F6  A 301 (-3.2A)
None
 0.74A 5fhrB-4p58A:
29.5		 5fhrB-4p58A:
97.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6q MSX2-INTERACTING
PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		4 SER A 602
SER A 591
GLN A 482
ASP A 549
 None
 1.41A 5fhrB-4p6qA:
undetectable		 5fhrB-4p6qA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pls ARM00010

(synthetic
construct) 		PF00514
(Arm) 		4 SER A  40
GLU A  72
SER A  30
GLN A  26
 None
 1.11A 5fhrB-4plsA:
undetectable		 5fhrB-4plsA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl4 GTP CYCLOHYDROLASE-2

(Helicobacter
pylori) 		PF00925
(GTP_cyclohydro2) 		4 SER A  63
GLU A  92
SER A  53
ASP A  67
 None
None
PPV  A 201 ( 4.8A)
None
 1.49A 5fhrB-4rl4A:
undetectable		 5fhrB-4rl4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 SER A 462
GLU A 515
SER A 489
GLN A 491
 None
 1.09A 5fhrB-4rvwA:
undetectable		 5fhrB-4rvwA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uv2 CURLI PRODUCTION
TRANSPORT COMPONENT
CSGG

(Escherichia
coli) 		PF03783
(CsgG) 		4 SER A 183
GLU A 210
GLN A  62
ASP A 155
 None
 1.50A 5fhrB-4uv2A:
undetectable		 5fhrB-4uv2A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zem TRANSLATION
INITIATION FACTOR
EIF2B-LIKE
PROTEIN,TRANSLATION
INITIATION FACTOR
EIF2B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF01008
(IF-2B) 		4 SER A 346
GLU A 339
GLN A 416
ASP A 343
 None
 1.36A 5fhrB-4zemA:
undetectable		 5fhrB-4zemA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a01 O-GLYCOSYLTRANSFERAS
E

(Drosophila
melanogaster) 		PF13374
(TPR_10)
PF13414
(TPR_11)
PF13844
(Glyco_transf_41) 		4 SER A 428
SER A 533
GLN A 525
ASP A 459
 None
 1.39A 5fhrB-5a01A:
3.6		 5fhrB-5a01A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		4 SER A 413
SER A 100
GLN A 172
ASP A  18
 ADP  A 501 ( 4.4A)
None
None
None
 1.47A 5fhrB-5dmhA:
undetectable		 5fhrB-5dmhA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		4 SER A 313
SER A 588
GLN A 614
ASP A 289
 None
 1.36A 5fhrB-5ek8A:
undetectable		 5fhrB-5ek8A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 SER A  91
GLU A 515
GLN A 550
ASP A 500
 None
 1.25A 5fhrB-5fp1A:
undetectable		 5fhrB-5fp1A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT CSL4

(Saccharomyces
cerevisiae) 		PF10447
(EXOSC1) 		4 GLU I 222
SER I 207
GLN I 149
ASP I 214
 None
 1.00A 5fhrB-5g06I:
undetectable		 5fhrB-5g06I:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0h HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		4 SER A 548
SER A 471
GLN A 468
ASP A 449
 None
 1.35A 5fhrB-5g0hA:
3.7		 5fhrB-5g0hA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmx CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		4 GLU A 171
SER A 182
GLN A 185
ASP A 137
 None
 1.49A 5fhrB-5gmxA:
undetectable		 5fhrB-5gmxA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		4 SER b 389
GLU b  87
SER b  81
ASP b  90
 None
 1.05A 5fhrB-5gw5b:
undetectable		 5fhrB-5gw5b:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		4 SER A 935
GLU A 849
SER A 609
GLN A 632
 GOL  A1202 ( 4.8A)
None
None
None
 1.38A 5fhrB-5ikzA:
2.3		 5fhrB-5ikzA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD
LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF04453
(OstA_C)
PF04390
(LptE) 		4 SER B 118
SER B  69
GLN A 540
ASP B 111
 None
 1.43A 5fhrB-5ivaB:
undetectable		 5fhrB-5ivaB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		4 SER A  81
GLU A 117
SER A 110
ASP A  78
 None
 1.47A 5fhrB-5k04A:
undetectable		 5fhrB-5k04A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Trichormus
variabilis) 		PF00701
(DHDPS) 		4 GLU A 165
SER A 147
GLN A 114
ASP A 171
 None
 1.32A 5fhrB-5ktlA:
2.2		 5fhrB-5ktlA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002

(Bacteroides
thetaiotaomicron) 		no annotation 4 SER A 163
SER A 227
GLN A 224
ASP A 165
 None
 1.47A 5fhrB-5mqpA:
undetectable		 5fhrB-5mqpA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mua RICIN B-RELATED
LECTIN

(Polyporus
squamosus) 		PF14200
(RicinB_lectin_2) 		4 SER A 188
GLU A 255
GLN A 147
ASP A 185
 None
 1.26A 5fhrB-5muaA:
undetectable		 5fhrB-5muaA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 MONOCLONAL ANTIBODY,
FAB FRAGMENT, HEAVY
CHAIN
MONOCLONAL ANTIBODY,
FAB FRAGMENT, LIGHT
CHAIN

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		4 SER H  63
SER L 100
GLN L   6
ASP L   1
 None
 1.33A 5fhrB-5tr1H:
undetectable		 5fhrB-5tr1H:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdr RAS PROTEIN

(Choanoflagellida) 		PF00071
(Ras) 		4 SER A  89
GLU A 144
SER A 146
ASP A  85
 None
None
GNP  A 203 (-3.5A)
None
 1.37A 5fhrB-5wdrA:
undetectable		 5fhrB-5wdrA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC

(Zea mays;
Zea mays) 		no annotation
no annotation 		4 SER 2  95
SER 2  72
GLN 3 166
ASP 2  89
 None
None
None
CLA  2 602 ( 3.4A)
 1.20A 5fhrB-5zji2:
undetectable		 5fhrB-5zji2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dgi D-ALANINE--D-ALANINE
LIGASE

(Vibrio cholerae) 		no annotation 4 SER A  23
GLU A  88
SER A 167
GLN A 165
 None
ACT  A 402 (-2.6A)
None
None
 1.37A 5fhrB-6dgiA:
undetectable		 5fhrB-6dgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fmq -

(-) 		no annotation 4 SER A 431
SER A 338
GLN A 337
ASP A 389
 None
None
ACT  A 707 (-4.1A)
EDO  A 701 (-3.5A)
 1.38A 5fhrB-6fmqA:
undetectable		 5fhrB-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)

(Homo sapiens) 		no annotation 4 SER A 454
GLU A 291
SER A  87
ASP A 451
 None
 1.32A 5fhrB-6gctA:
undetectable		 5fhrB-6gctA:
undetectable