SIMILAR PATTERNS OF AMINO ACIDS FOR 5FHQ_A_SAMA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		5 MET A  61
GLY A  87
TYR A  89
SER A  93
ASP A 163
 SPF  A 401 (-4.1A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.7A)
SAH  A 301 (-2.7A)
CA  A 305 (-2.5A)
 0.54A 5fhqA-1susA:
17.4		 5fhqA-1susA:
25.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bwm CATECHOL
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		9 MET A  40
GLY A  66
TYR A  68
SER A  72
GLU A  90
SER A 119
GLN A 120
ASP A 141
TRP A 143
 SAM  A 301 (-3.7A)
SAM  A 301 (-3.2A)
SAM  A 301 (-4.7A)
SAM  A 301 (-2.9A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.6A)
MG  A 300 (-2.4A)
SAM  A 301 ( 3.4A)
 0.21A 5fhqA-3bwmA:
34.9		 5fhqA-3bwmA:
81.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		5 GLY A 109
GLU A 133
SER A 162
GLN A 163
ASP A 184
 2F6  A 301 (-3.6A)
2F6  A 301 (-2.7A)
2F6  A 301 (-3.2A)
2F6  A 301 (-3.8A)
None
 0.39A 5fhqA-4p58A:
29.4		 5fhqA-4p58A:
97.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		5 GLY A 109
SER A 115
GLU A 133
SER A 162
ASP A 184
 2F6  A 301 (-3.6A)
None
2F6  A 301 (-2.7A)
2F6  A 301 (-3.2A)
None
 0.72A 5fhqA-4p58A:
29.4		 5fhqA-4p58A:
97.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymg PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE

(Podospora
anserina) 		PF01596
(Methyltransf_3) 		5 GLY A  73
TYR A  75
SER A  79
GLU A  98
ASP A 144
 SAM  A1001 (-3.3A)
SAM  A1001 (-4.8A)
SAM  A1001 (-2.7A)
SAM  A1001 (-2.7A)
SAM  A1001 (-3.6A)
 0.18A 5fhqA-4ymgA:
19.0		 5fhqA-4ymgA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kva CAFFEOYL-COA
O-METHYLTRANSFERASE

(Sorghum bicolor) 		PF01596
(Methyltransf_3) 		5 MET A  75
GLY A 101
TYR A 103
SER A 107
ASP A 177
 SAM  A 301 (-3.8A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.8A)
SAM  A 301 (-2.8A)
CA  A 302 ( 2.2A)
 0.45A 5fhqA-5kvaA:
17.5		 5fhqA-5kvaA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		5 GLY A 598
TYR A 211
SER A 591
GLU A 202
ASP A 641
 None
 1.47A 5fhqA-5mfaA:
0.0		 5fhqA-5mfaA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 5 GLY A 598
TYR A 211
SER A 591
GLU A 202
ASP A 641
 None
 1.46A 5fhqA-6azpA:
0.0		 5fhqA-6azpA:
undetectable