SIMILAR PATTERNS OF AMINO ACIDS FOR 5FCT_B_C2FB402_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7g TYROSINE
PHENOL-LYASE

(Pantoea
agglomerans) 		PF01212
(Beta_elim_lyase) 		3 ASN A 151
ASP A 327
GLY A 326
 None
 0.62A 5fctB-1c7gA:
0.0		 5fctB-1c7gA:
20.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ci7 PROTEIN (THYMIDYLATE
SYNTHASE)

(Pneumocystis
carinii) 		PF00303
(Thymidylat_synt) 		3 ASN A  90
ASP A 202
GLY A 206
 CB3  A 768 (-3.8A)
CB3  A 768 ( 3.6A)
UMP  A 767 (-3.7A)
 0.63A 5fctB-1ci7A:
44.0		 5fctB-1ci7A:
58.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE

(Providencia
rettgeri) 		PF01804
(Penicil_amidase) 		3 ASN B 315
ASP B 440
GLY B 439
 None
 0.65A 5fctB-1cp9B:
0.0		 5fctB-1cp9B:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1p TYROSINE PHOSPHATASE

(Saccharomyces
cerevisiae) 		PF01451
(LMWPc) 		3 ASN A 122
ASP A 118
GLY A 117
 None
 0.51A 5fctB-1d1pA:
0.0		 5fctB-1d1pA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dql IGM MEZ
IMMUNOGLOBULIN

(Homo sapiens) 		PF07686
(V-set) 		3 ASN H 100
ASP H  54
GLY H  55
 None
 0.63A 5fctB-1dqlH:
undetectable		 5fctB-1dqlH:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
SMALL SUBUNIT

(Desulfovibrio
desulfuricans) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		3 ASN A 255
ASP A 135
GLY A 132
 H2S  A 904 (-4.9A)
None
None
 0.67A 5fctB-1e3dA:
0.0		 5fctB-1e3dA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1c CYTOCHROME C549

(Arthrospira
maxima) 		PF14495
(Cytochrom_C550) 		3 ASN A  49
ASP A  83
GLY A  84
 HEM  A 200 ( 4.8A)
None
None
 0.56A 5fctB-1f1cA:
undetectable		 5fctB-1f1cA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ftg APOFLAVODOXIN

(Nostoc sp. PCC
7119) 		PF00258
(Flavodoxin_1) 		3 ASN A  58
ASP A  65
GLY A   9
 None
 0.65A 5fctB-1ftgA:
0.0		 5fctB-1ftgA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882

(Lophonetta
specularioides) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		3 ASN A 263
ASP A 149
GLY A 254
 None
 0.62A 5fctB-1h8lA:
0.0		 5fctB-1h8lA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkg HEXOKINASE A

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 ASN A 111
ASP A  73
GLY A  72
 None
 0.51A 5fctB-1hkgA:
1.0		 5fctB-1hkgA:
19.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvy THYMIDYLATE SYNTHASE

(Homo sapiens) 		PF00303
(Thymidylat_synt) 		3 ASN A 112
ASP A 218
GLY A 222
 D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
 0.44A 5fctB-1hvyA:
48.2		 5fctB-1hvyA:
93.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhy METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		3 ASN B 245
ASP B 309
GLY B 313
 None
 0.64A 5fctB-1mhyB:
undetectable		 5fctB-1mhyB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mz5 SIALIDASE

(Trypanosoma
rangeli) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		3 ASN A 119
ASP A 126
GLY A 127
 None
 0.46A 5fctB-1mz5A:
undetectable		 5fctB-1mz5A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ng0 COAT PROTEIN

(Cocksfoot
mottle virus) 		PF00729
(Viral_coat) 		3 ASN A 158
ASP A 164
GLY A 177
 ASN  A 158 ( 0.6A)
ASP  A 164 ( 0.6A)
GLY  A 177 ( 0.0A)
 0.67A 5fctB-1ng0A:
undetectable		 5fctB-1ng0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npu PROGRAMMED CELL
DEATH PROTEIN 1

(Mus musculus) 		PF07686
(V-set) 		3 ASN A  83
ASP A  79
GLY A  14
 None
 0.60A 5fctB-1npuA:
undetectable		 5fctB-1npuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p6s RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00169
(PH) 		3 ASN A  54
ASP A  32
GLY A  33
 None
 0.66A 5fctB-1p6sA:
undetectable		 5fctB-1p6sA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		3 ASN A 219
ASP A 375
GLY A 374
 None
 0.66A 5fctB-1qb4A:
undetectable		 5fctB-1qb4A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcw FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae) 		PF01070
(FMN_dh) 		3 ASN A 157
ASP A 282
GLY A 350
 None
 0.61A 5fctB-1qcwA:
undetectable		 5fctB-1qcwA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)

(Homo sapiens) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		3 ASN A 179
ASP A 134
GLY A 133
 None
ZN  A 262 ( 2.4A)
None
 0.64A 5fctB-1qh5A:
undetectable		 5fctB-1qh5A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF16363
(GDP_Man_Dehyd) 		3 ASN A  80
ASP A  59
GLY A  58
 None
NDP  A1501 (-2.9A)
None
 0.62A 5fctB-1rpnA:
undetectable		 5fctB-1rpnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		3 ASN A 286
ASP A 293
GLY A 294
 None
 0.62A 5fctB-1rt8A:
undetectable		 5fctB-1rt8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Toxoplasma
gondii) 		no annotation 3 ASN D 194
ASP D 220
GLY D 232
 None
 0.65A 5fctB-1upfD:
undetectable		 5fctB-1upfD:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		3 ASN A 149
ASP A 118
GLY A 145
 None
 0.67A 5fctB-1wd3A:
undetectable		 5fctB-1wd3A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwz HYPOTHETICAL PROTEIN
PH1933

(Pyrococcus
horikoshii) 		PF00583
(Acetyltransf_1) 		3 ASN A 118
ASP A  55
GLY A  56
 None
 0.55A 5fctB-1wwzA:
undetectable		 5fctB-1wwzA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		3 ASN A 201
ASP A 213
GLY A 178
 None
 0.47A 5fctB-1x3lA:
undetectable		 5fctB-1x3lA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10) 		3 ASN A 661
ASP A 648
GLY A 653
 None
 0.67A 5fctB-1xyzA:
undetectable		 5fctB-1xyzA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE

(Ipomoea batatas) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		3 ASN A 168
ASP A 134
GLY A 162
 None
FE  A 429 ( 3.4A)
None
 0.68A 5fctB-1xzwA:
undetectable		 5fctB-1xzwA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd8 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3

(Homo sapiens) 		PF03127
(GAT) 		3 ASN G 285
ASP G 278
GLY G 277
 None
 0.66A 5fctB-1yd8G:
undetectable		 5fctB-1yd8G:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)

(Mycobacterium
tuberculosis) 		PF00484
(Pro_CA) 		3 ASN A   3
ASP A  68
GLY A  67
 None
 0.63A 5fctB-2a5vA:
undetectable		 5fctB-2a5vA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaf ARGININE DEIMINASE

(Pseudomonas
aeruginosa) 		PF02274
(Amidinotransf) 		3 ASN A 379
ASP A 357
GLY A 344
 None
 0.65A 5fctB-2aafA:
undetectable		 5fctB-2aafA:
21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		3 ASN A 104
ASP A 219
GLY A 223
 CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
 0.21A 5fctB-2aazA:
undetectable		 5fctB-2aazA:
59.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwm PSATHYRELLA VELUTINA
LECTIN PVL

(Lacrymaria
velutina) 		PF13517
(VCBS) 		3 ASN A  34
ASP A 347
GLY A 348
 None
CA  A1401 (-3.0A)
None
 0.63A 5fctB-2bwmA:
undetectable		 5fctB-2bwmA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwm PSATHYRELLA VELUTINA
LECTIN PVL

(Lacrymaria
velutina) 		PF13517
(VCBS) 		3 ASN A 255
ASP A 181
GLY A 182
 None
CA  A1402 (-3.0A)
None
 0.55A 5fctB-2bwmA:
undetectable		 5fctB-2bwmA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2can ORNITHINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00202
(Aminotran_3) 		3 ASN A 378
ASP A 350
GLY A 273
 None
 0.61A 5fctB-2canA:
undetectable		 5fctB-2canA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cod CENTAURIN-DELTA 1

(Homo sapiens) 		PF00169
(PH) 		3 ASN A  88
ASP A  65
GLY A  64
 None
 0.66A 5fctB-2codA:
undetectable		 5fctB-2codA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cpt VACUOLAR SORTING
PROTEIN 4B

(Homo sapiens) 		PF04212
(MIT) 		3 ASN A 107
ASP A 110
GLY A 111
 None
 0.44A 5fctB-2cptA:
undetectable		 5fctB-2cptA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf7 CLASS B ACID
PHOSPHATASE

(Escherichia
coli) 		PF03767
(Acid_phosphat_B) 		3 ASN A 150
ASP A  44
GLY A 166
 None
MG  A 700 ( 2.5A)
None
 0.61A 5fctB-2hf7A:
undetectable		 5fctB-2hf7A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icg LIN2918 PROTEIN

(Listeria
innocua) 		PF14568
(SUKH_6) 		3 ASN A 133
ASP A  91
GLY A  90
 None
 0.47A 5fctB-2icgA:
undetectable		 5fctB-2icgA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l2b STICHOLYSIN-2

(Stichodactyla
helianthus) 		PF06369
(Anemone_cytotox) 		3 ASN A 138
ASP A 143
GLY A 142
 None
 0.47A 5fctB-2l2bA:
undetectable		 5fctB-2l2bA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 ASN A 113
ASP A 257
GLY A 261
 None
 0.63A 5fctB-2nq5A:
undetectable		 5fctB-2nq5A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE

(Paramecium
bursaria
Chlorella virus
1) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 ASN A   6
ASP A 343
GLY A 342
 None
 0.65A 5fctB-2nv9A:
undetectable		 5fctB-2nv9A:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		3 ASN A 319
ASP A 426
GLY A 430
 CB3  A 604 ( 4.3A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
 0.34A 5fctB-2oipA:
44.9		 5fctB-2oipA:
34.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		3 ASN A 259
ASP A  49
GLY A  50
 None
 0.66A 5fctB-2oxtA:
undetectable		 5fctB-2oxtA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfe CALPAIN-7

(Homo sapiens) 		PF01067
(Calpain_III) 		3 ASN A 706
ASP A 764
GLY A 763
 None
None
BR  A  11 ( 4.1A)
 0.64A 5fctB-2qfeA:
undetectable		 5fctB-2qfeA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qri H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN K-B ALPHA
CHAIN, BETA-2
MICROGLOBULIN,
OVALBUMIN-DERIVED
PEPTIDE

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 ASN A  21
ASP A 238
GLY A 237
 None
 0.66A 5fctB-2qriA:
undetectable		 5fctB-2qriA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5g CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 2

(Homo sapiens) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		3 ASN A 237
ASP A  23
GLY A  24
 None
 0.67A 5fctB-2r5gA:
undetectable		 5fctB-2r5gA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uu7 GLUTAMINE SYNTHETASE

(Canis lupus) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		3 ASN A 112
ASP A 216
GLY A 215
 None
 0.67A 5fctB-2uu7A:
undetectable		 5fctB-2uu7A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		3 ASN G1383
ASP G1344
GLY G1345
 None
 0.66A 5fctB-2uv8G:
undetectable		 5fctB-2uv8G:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v35 ELASTASE-1

(Sus scrofa) 		PF00089
(Trypsin) 		3 ASN A 133
ASP A 186
GLY A 185
 None
 0.62A 5fctB-2v35A:
undetectable		 5fctB-2v35A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa5 FILAMIN-B

(Homo sapiens) 		PF00307
(CH) 		3 ASN A 160
ASP A 167
GLY A 168
 None
 0.65A 5fctB-2wa5A:
undetectable		 5fctB-2wa5A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN

(Shewanella
oneidensis) 		PF00854
(PTR2) 		3 ASN A  86
ASP A  79
GLY A  75
 None
 0.60A 5fctB-2xutA:
undetectable		 5fctB-2xutA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF03714
(PUD) 		3 ASN A 817
ASP A 736
GLY A 737
 None
 0.62A 5fctB-2ya1A:
undetectable		 5fctB-2ya1A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 ASN A 362
ASP A 281
GLY A 282
 None
 0.50A 5fctB-2ya2A:
undetectable		 5fctB-2ya2A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yun NOSTRIN

(Homo sapiens) 		PF14604
(SH3_9) 		3 ASN A  65
ASP A  30
GLY A  29
 None
 0.48A 5fctB-2yunA:
undetectable		 5fctB-2yunA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8l UNCHARACTERIZED
PROTEIN

(Novosphingobium
aromaticivorans) 		PF13577
(SnoaL_4) 		3 ASN A  63
ASP A 102
GLY A 100
 None
 0.68A 5fctB-3b8lA:
undetectable		 5fctB-3b8lA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkh LYTIC
TRANSGLYCOSYLASE

(Pseudomonas
virus phiKZ) 		PF01464
(SLT)
PF01471
(PG_binding_1) 		3 ASN A  21
ASP A  31
GLY A  32
 None
 0.52A 5fctB-3bkhA:
undetectable		 5fctB-3bkhA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3y O-METHYLTRANSFERASE

(Mesembryanthemum
crystallinum) 		PF01596
(Methyltransf_3) 		3 ASN A 210
ASP A 228
GLY A  13
 None
 0.53A 5fctB-3c3yA:
undetectable		 5fctB-3c3yA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdk SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
B

(Bacillus
subtilis) 		PF01144
(CoA_trans) 		3 ASN B 134
ASP B 112
GLY B 111
 None
 0.31A 5fctB-3cdkB:
undetectable		 5fctB-3cdkB:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clq UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF06545
(DUF1116) 		3 ASN A 437
ASP A 241
GLY A 240
 None
 0.61A 5fctB-3clqA:
undetectable		 5fctB-3clqA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doh ESTERASE

(Thermotoga
maritima) 		PF02230
(Abhydrolase_2) 		3 ASN A 118
ASP A 372
GLY A 375
 None
 0.57A 5fctB-3dohA:
undetectable		 5fctB-3dohA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4v NADH:FMN
OXIDOREDUCTASE LIKE
PROTEIN

(Methylobacillus
flagellatus) 		PF01613
(Flavin_Reduct) 		3 ASN A  87
ASP A 161
GLY A 160
 FMN  A 300 ( 4.5A)
None
None
 0.61A 5fctB-3e4vA:
undetectable		 5fctB-3e4vA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD

(Escherichia
coli) 		PF03958
(Secretin_N) 		3 ASN A 133
ASP A 101
GLY A 100
 None
 0.63A 5fctB-3ezjA:
undetectable		 5fctB-3ezjA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7p PLECTIN-1

(Homo sapiens) 		PF00307
(CH) 		3 ASN A 209
ASP A 216
GLY A 217
 None
EDO  A 294 (-3.6A)
None
 0.64A 5fctB-3f7pA:
undetectable		 5fctB-3f7pA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fky GLUTAMINE SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		3 ASN A 109
ASP A 213
GLY A 212
 None
 0.64A 5fctB-3fkyA:
undetectable		 5fctB-3fkyA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ASN A 446
ASP A 504
GLY A 442
 None
 0.67A 5fctB-3gwjA:
undetectable		 5fctB-3gwjA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdl ROYAL PALM TREE
PEROXIDASE

(Roystonea regia) 		PF00141
(peroxidase) 		3 ASN A 181
ASP A 248
GLY A 243
 None
 0.62A 5fctB-3hdlA:
undetectable		 5fctB-3hdlA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijl MUCONATE
CYCLOISOMERASE

(Bacteroides
thetaiotaomicron) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASN A 226
ASP A 348
GLY A 325
 MG  A 386 ( 4.6A)
PRO  A 384 (-3.4A)
None
 0.67A 5fctB-3ijlA:
undetectable		 5fctB-3ijlA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4

(Homo sapiens) 		PF00557
(Peptidase_M24) 		3 ASN A 120
ASP A 196
GLY A 197
 None
 0.61A 5fctB-3j2iA:
undetectable		 5fctB-3j2iA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4w UNCHARACTERIZED
PROTEIN BB4693

(Bordetella
bronchiseptica) 		PF04909
(Amidohydro_2) 		3 ASN A  68
ASP A  79
GLY A  14
 None
 0.66A 5fctB-3k4wA:
undetectable		 5fctB-3k4wA:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		3 ASN A 310
ASP A 416
GLY A 420
 GOL  A 516 (-3.7A)
None
None
 0.26A 5fctB-3kjrA:
45.3		 5fctB-3kjrA:
34.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3li9 HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE

(Methanosarcina
mazei) 		PF02743
(dCache_1) 		3 ASN A  56
ASP A 289
GLY A 288
 None
 0.64A 5fctB-3li9A:
undetectable		 5fctB-3li9A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm8 THIAMINE
PYROPHOSPHOKINASE

(Bacillus
subtilis) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		3 ASN A 113
ASP A  32
GLY A  34
 None
 0.57A 5fctB-3lm8A:
undetectable		 5fctB-3lm8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		3 ASN A 433
ASP A  49
GLY A  50
 None
 0.46A 5fctB-3lscA:
undetectable		 5fctB-3lscA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxr IPGB2

(Shigella
flexneri) 		PF03278
(IpaB_EvcA) 		3 ASN F  76
ASP F  92
GLY F  91
 None
 0.62A 5fctB-3lxrF:
undetectable		 5fctB-3lxrF:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp2 NON-STRUCTURAL
PROTEIN 3

(Alphacoronavirus
1) 		PF08715
(Viral_protease) 		3 ASN A  65
ASP A  29
GLY A  76
 None
 0.67A 5fctB-3mp2A:
undetectable		 5fctB-3mp2A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx7 FAS APOPTOTIC
INHIBITORY MOLECULE
1

(Homo sapiens) 		PF06905
(FAIM1) 		3 ASN A  82
ASP A  14
GLY A  15
 None
 0.65A 5fctB-3mx7A:
undetectable		 5fctB-3mx7A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		3 ASN A 574
ASP A 531
GLY A 532
 None
 0.50A 5fctB-3nzqA:
undetectable		 5fctB-3nzqA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4r DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Homo sapiens) 		PF13561
(adh_short_C2) 		3 ASN A 120
ASP A  42
GLY A  43
 None
NAP  A 601 (-3.9A)
NAP  A 601 (-3.0A)
 0.60A 5fctB-3o4rA:
undetectable		 5fctB-3o4rA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogk CORONATINE-INSENSITI
VE PROTEIN 1

(Arabidopsis
thaliana) 		no annotation 3 ASN B 198
ASP B 299
GLY B 276
 None
 0.59A 5fctB-3ogkB:
undetectable		 5fctB-3ogkB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD

(Escherichia
coli) 		PF03958
(Secretin_N) 		3 ASN D 133
ASP D 101
GLY D 100
 None
 0.54A 5fctB-3ossD:
undetectable		 5fctB-3ossD:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf7 BENZOYL-COA
OXYGENASE COMPONENT
B

(Azoarcus
evansii) 		no annotation 3 ASN A 289
ASP A 410
GLY A 411
 None
 0.46A 5fctB-3pf7A:
undetectable		 5fctB-3pf7A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnk PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ASN A 256
ASP A 241
GLY A 242
 None
 0.63A 5fctB-3qnkA:
undetectable		 5fctB-3qnkA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rha PUTRESCINE OXIDASE

(Paenarthrobacter
aurescens) 		PF01593
(Amino_oxidase) 		3 ASN A 166
ASP A  96
GLY A  97
 None
 0.61A 5fctB-3rhaA:
undetectable		 5fctB-3rhaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		3 ASN A 161
ASP A 290
GLY A 266
 None
 0.58A 5fctB-3sggA:
undetectable		 5fctB-3sggA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl1 ARGINASE

(Plasmodium
falciparum) 		PF00491
(Arginase) 		3 ASN A 349
ASP A 383
GLY A 382
 None
 0.45A 5fctB-3sl1A:
undetectable		 5fctB-3sl1A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		3 ASN A  77
ASP A 127
GLY A 126
 EB4  A 328 (-3.5A)
EB4  A 328 (-3.5A)
EB4  A 328 (-3.4A)
 0.56A 5fctB-3tlkA:
undetectable		 5fctB-3tlkA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1x PUTATIVE GLYCOSYL
HYDROLASE

(Parabacteroides
distasonis) 		PF06439
(DUF1080) 		3 ASN A 185
ASP A 143
GLY A 115
 None
 0.55A 5fctB-3u1xA:
undetectable		 5fctB-3u1xA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uji FAB REGION OF THE
HEAVY CHAIN OF
ANTI-HIV-1 V3
MONOCLONAL ANTIBODY
2558

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASN H  31
ASP H 100
GLY H  99
 None
 0.64A 5fctB-3ujiH:
undetectable		 5fctB-3ujiH:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ul4 CELLULOSOME ENZYME,
DOCKERIN TYPE I

(Ruminiclostridium
thermocellum) 		PF00404
(Dockerin_1) 		3 ASN B   5
ASP B  44
GLY B  45
 None
CA  B  66 (-2.9A)
None
 0.43A 5fctB-3ul4B:
undetectable		 5fctB-3ul4B:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v1v 2-METHYLISOBORNEOL
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 3 ASN A 194
ASP A 162
GLY A 163
 None
 0.59A 5fctB-3v1vA:
undetectable		 5fctB-3v1vA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		3 ASN A   7
ASP A 137
GLY A 309
 None
FE2  A 601 ( 3.3A)
CA0  A 602 ( 4.0A)
 0.56A 5fctB-3vexA:
undetectable		 5fctB-3vexA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		3 ASN A  14
ASP A 137
GLY A 309
 None
FE2  A 601 ( 3.3A)
CA0  A 602 ( 4.0A)
 0.63A 5fctB-3vexA:
undetectable		 5fctB-3vexA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo) 		PF00082
(Peptidase_S8) 		3 ASN A 247
ASP A 200
GLY A 142
 None
 0.53A 5fctB-3vtaA:
undetectable		 5fctB-3vtaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0u TAIL FIBER PROTEIN

(Escherichia
virus T7) 		PF12604
(gp37_C) 		3 ASN A 546
ASP A 520
GLY A 521
 None
 0.45A 5fctB-4a0uA:
undetectable		 5fctB-4a0uA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE

(Homo sapiens) 		PF02668
(TauD)
PF06155
(DUF971) 		3 ASN A 333
ASP A 228
GLY A 227
 None
 0.57A 5fctB-4bhiA:
undetectable		 5fctB-4bhiA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1i BETA-GALACTOSIDASE,
PUTATIVE, BGL35A

(Cellvibrio
japonicus) 		PF02449
(Glyco_hydro_42) 		3 ASN A 392
ASP A 353
GLY A 387
 None
 0.61A 5fctB-4d1iA:
undetectable		 5fctB-4d1iA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dix PLECTIN-RELATED
PROTEIN

(Arabidopsis
thaliana) 		PF16709
(SCAB-IgPH) 		3 ASN A 439
ASP A 284
GLY A 285
 None
 0.45A 5fctB-4dixA:
undetectable		 5fctB-4dixA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dza LYSINE RACEMASE

(Proteus
mirabilis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 ASN A 244
ASP A 216
GLY A 169
 LLP  A  74 ( 4.5A)
None
None
 0.55A 5fctB-4dzaA:
undetectable		 5fctB-4dzaA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e09 PLASMID PARTITIONING
PROTEIN PARF

(Escherichia
coli) 		PF01656
(CbiA) 		3 ASN A  21
ASP A 187
GLY A 188
 None
 0.61A 5fctB-4e09A:
undetectable		 5fctB-4e09A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eex ALCOHOL
DEHYDROGENASE 1

(Lactococcus
lactis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASN A  52
ASP A  11
GLY A  12
 None
 0.66A 5fctB-4eexA:
undetectable		 5fctB-4eexA:
22.04