SIMILAR PATTERNS OF AMINO ACIDS FOR 5FCT_B_C2FB402_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ci7 | PROTEIN (THYMIDYLATESYNTHASE) (Pneumocystiscarinii) |
PF00303(Thymidylat_synt) | 6 | LYS A 55VAL A 57PHE A 58LEU A 205TYR A 242MET A 293 | CB3 A 768 ( 4.9A)CB3 A 768 ( 4.0A)CB3 A 768 (-3.6A)CB3 A 768 ( 4.4A)CB3 A 768 ( 4.7A)None | 1.14A | 5fctB-1ci7A:44.0 | 5fctB-1ci7A:58.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ci7 | PROTEIN (THYMIDYLATESYNTHASE) (Pneumocystiscarinii) |
PF00303(Thymidylat_synt) | 9 | VAL A 57PHE A 58ILE A 86LEU A 170CYH A 173LEU A 205TYR A 242MET A 293MET A 295 | CB3 A 768 ( 4.0A)CB3 A 768 (-3.6A)CB3 A 768 (-3.6A)UMP A 767 (-4.7A)UMP A 767 (-1.9A)CB3 A 768 ( 4.4A)CB3 A 768 ( 4.7A)NoneCB3 A 768 (-3.8A) | 0.68A | 5fctB-1ci7A:44.0 | 5fctB-1ci7A:58.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ci7 | PROTEIN (THYMIDYLATESYNTHASE) (Pneumocystiscarinii) |
PF00303(Thymidylat_synt) | 9 | VAL A 57PHE A 58ILE A 86TRP A 87LEU A 170LEU A 205TYR A 242MET A 293MET A 295 | CB3 A 768 ( 4.0A)CB3 A 768 (-3.6A)CB3 A 768 (-3.6A)NoneUMP A 767 (-4.7A)CB3 A 768 ( 4.4A)CB3 A 768 ( 4.7A)NoneCB3 A 768 (-3.8A) | 0.68A | 5fctB-1ci7A:44.0 | 5fctB-1ci7A:58.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f5a | POLY(A) POLYMERASE (Bos taurus) |
PF01909(NTP_transf_2)PF04926(PAP_RNA-bind)PF04928(PAP_central) | 5 | VAL A 275PHE A 273ILE A 227LEU A 105LEU A 252 | None | 1.11A | 5fctB-1f5aA:0.0 | 5fctB-1f5aA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gcy | GLUCAN1,4-ALPHA-MALTOTETRAHYDROLASE (Pseudomonasstutzeri) |
PF00128(Alpha-amylase)PF09081(DUF1921) | 5 | VAL A 330PHE A 51LEU A 95LEU A 110ALA A 187 | None | 1.19A | 5fctB-1gcyA:0.0 | 5fctB-1gcyA:19.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvy | THYMIDYLATE SYNTHASE (Homo sapiens) |
PF00303(Thymidylat_synt) | 12 | LYS A 77VAL A 79PHE A 80ILE A 108TRP A 109LEU A 192CYH A 195LEU A 221TYR A 258MET A 309MET A 311ALA A 312 | D16 A 414 ( 4.3A)NoneD16 A 414 (-3.7A)D16 A 414 (-3.7A)D16 A 414 (-3.7A)NoneUMP A 314 (-1.8A)D16 A 414 (-4.0A)UMP A 314 ( 4.4A)NoneD16 A 414 (-3.4A)D16 A 414 (-3.6A) | 0.61A | 5fctB-1hvyA:48.2 | 5fctB-1hvyA:93.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1j3j | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00303(Thymidylat_synt) | 5 | LYS C 372CYH C 490LEU C 516TYR C 553MET C 604 | NoneUMP C 611 (-3.5A)NoneUMP C 611 (-4.9A)None | 0.96A | 5fctB-1j3jC:41.0 | 5fctB-1j3jC:50.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pw4 | GLYCEROL-3-PHOSPHATETRANSPORTER (Escherichiacoli) |
PF07690(MFS_1) | 5 | PHE A 195ILE A 198LEU A 96LEU A 43ALA A 39 | None | 1.35A | 5fctB-1pw4A:0.0 | 5fctB-1pw4A:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vs0 | PUTATIVE DNALIGASE-LIKE PROTEINRV0938/MT0965 (Mycobacteriumtuberculosis) |
PF01068(DNA_ligase_A_M)PF04679(DNA_ligase_A_C) | 5 | VAL A 592PHE A 559CYH A 606LEU A 595ALA A 473 | NoneAPK A 481 ( 3.4A)NoneNoneNone | 1.50A | 5fctB-1vs0A:0.0 | 5fctB-1vs0A:24.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wdu | TRAS1 ORF2P (Bombyx mori) |
PF14529(Exo_endo_phos_2) | 5 | VAL A 233ILE A 54LEU A 122LEU A 26ALA A 50 | None | 1.21A | 5fctB-1wduA:0.6 | 5fctB-1wduA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wkp | FLOWERING LOCUS TPROTEIN (Arabidopsisthaliana) |
PF01161(PBP) | 5 | PHE A 22ILE A 123LEU A 86LEU A 153TYR A 151 | None | 1.45A | 5fctB-1wkpA:0.0 | 5fctB-1wkpA:21.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2aaz | THYMIDYLATE SYNTHASE (Cryptococcusneoformans) |
PF00303(Thymidylat_synt) | 11 | LYS A 69VAL A 71PHE A 72ILE A 100TRP A 101LEU A 184CYH A 187LEU A 222TYR A 259MET A 313MET A 315 | CB3 A2351 ( 4.1A)NoneCB3 A2351 (-3.9A)CB3 A2351 (-3.6A)CB3 A2351 (-3.7A)NoneUMP A 350 (-1.8A)CB3 A2351 (-4.1A)CB3 A2351 ( 4.3A)NoneCB3 A2351 (-3.4A) | 0.37A | 5fctB-2aazA:undetectable | 5fctB-2aazA:59.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bkl | PROLYL ENDOPEPTIDASE (Myxococcusxanthus) |
PF00326(Peptidase_S9)PF02897(Peptidase_S9_N) | 5 | VAL A 434PHE A 384ILE A 468LEU A 59LEU A 449 | None | 1.46A | 5fctB-2bklA:undetectable | 5fctB-2bklA:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f07 | YVDT (Bacillussubtilis) |
PF00440(TetR_N) | 5 | PHE A 92ILE A 183LEU A 191LEU A 87ALA A 152 | None | 1.30A | 5fctB-2f07A:undetectable | 5fctB-2f07A:20.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2h2q | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomacruzi) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | LYS A 285PHE A 288ILE A 316LEU A 429TYR A 466 | NoneNoneNoneNone DU A 611 (-4.6A) | 1.24A | 5fctB-2h2qA:40.0 | 5fctB-2h2qA:39.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2h2q | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomacruzi) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 6 | VAL A 287PHE A 288ILE A 316CYH A 403LEU A 429TYR A 466 | NoneNoneNone DU A 611 (-3.7A)None DU A 611 (-4.6A) | 1.01A | 5fctB-2h2qA:40.0 | 5fctB-2h2qA:39.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2h2q | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomacruzi) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | VAL A 287PHE A 288ILE A 316TRP A 317LEU A 400 | None | 0.52A | 5fctB-2h2qA:40.0 | 5fctB-2h2qA:39.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h63 | BILIVERDIN REDUCTASEA (Homo sapiens) |
PF01408(GFO_IDH_MocA)PF09166(Biliv-reduc_cat) | 5 | VAL A 70PHE A 87ILE A 73LEU A 121ALA A 107 | None | 1.48A | 5fctB-2h63A:undetectable | 5fctB-2h63A:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o62 | HYPOTHETICAL PROTEIN (Nostocpunctiforme) |
PF12204(DUF3598) | 5 | VAL A 66PHE A 63TRP A 15LEU A 126LEU A 9 | None | 1.41A | 5fctB-2o62A:undetectable | 5fctB-2o62A:21.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2oip | CHAIN A, CRYSTALSTRUCTURE OF DHFR (Cryptosporidiumhominis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 11 | LYS A 284VAL A 286ILE A 315TRP A 316LEU A 399CYH A 402LEU A 429TYR A 466MET A 517MET A 519ALA A 520 | CB3 A 604 ( 4.7A)NoneCB3 A 604 ( 3.7A)CB3 A 604 ( 4.4A)NoneUMP A 603 ( 3.0A)CB3 A 604 ( 4.4A)UMP A 603 ( 4.3A)NoneCB3 A 604 ( 3.5A)CB3 A 604 ( 4.0A) | 0.53A | 5fctB-2oipA:44.9 | 5fctB-2oipA:34.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p0n | HYPOTHETICAL PROTEINNMB1532 (Neisseriameningitidis) |
PF01814(Hemerythrin) | 5 | VAL A 130ILE A 55LEU A 49CYH A 44ALA A 111 | None | 1.18A | 5fctB-2p0nA:undetectable | 5fctB-2p0nA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2quq | CENTROMEREDNA-BINDING PROTEINCOMPLEX CBF3 SUBUNITB (Saccharomycescerevisiae) |
PF16846(Cep3) | 5 | ILE A 239LEU A 256CYH A 260LEU A 162TYR A 158 | None | 1.38A | 5fctB-2quqA:undetectable | 5fctB-2quqA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qv5 | UNCHARACTERIZEDPROTEIN ATU2773 (Agrobacteriumfabrum) |
PF04748(Polysacc_deac_2) | 5 | PHE A 303ILE A 296LEU A 229MET A 265ALA A 266 | None | 1.38A | 5fctB-2qv5A:undetectable | 5fctB-2qv5A:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2riu | 3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATESYNTHASE (Candidaalbicans) |
PF00926(DHBP_synthase) | 5 | VAL A 51LEU A 72CYH A 91MET A 37ALA A 161 | None | 1.26A | 5fctB-2riuA:undetectable | 5fctB-2riuA:23.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2tdd | THYMIDYLATE SYNTHASE (Lactobacilluscasei) |
PF00303(Thymidylat_synt) | 6 | LYS A 50VAL A 52ILE A 81TRP A 82LEU A 195CYH A 198 | THF A 568 ( 4.7A)NoneTHF A 568 ( 4.8A)THF A 568 ( 4.6A)THF A 568 (-4.6A)UFP A 529 (-3.0A) | 0.98A | 5fctB-2tddA:34.7 | 5fctB-2tddA:43.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2tdd | THYMIDYLATE SYNTHASE (Lactobacilluscasei) |
PF00303(Thymidylat_synt) | 6 | LYS A 50VAL A 52LEU A 195CYH A 198LEU A 224TYR A 261 | THF A 568 ( 4.7A)NoneTHF A 568 (-4.6A)UFP A 529 (-3.0A)THF A 568 (-3.6A)UFP A 529 (-4.7A) | 0.99A | 5fctB-2tddA:34.7 | 5fctB-2tddA:43.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wj3 | 1-H-3-HYDROXY-4-OXOQUINALDINE2,4-DIOXYGENASE (Paenarthrobacternitroguajacolicus) |
PF00561(Abhydrolase_1) | 5 | VAL A 42ILE A 19LEU A 90LEU A 32ALA A 29 | None | 1.43A | 5fctB-2wj3A:undetectable | 5fctB-2wj3A:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a8u | OMEGA-AMINOACID--PYRUVATEAMINOTRANSFERASE (Pseudomonasputida) |
PF00202(Aminotran_3) | 5 | VAL X 113PHE X 114LEU X 162LEU X 283ALA X 222 | None | 1.03A | 5fctB-3a8uX:undetectable | 5fctB-3a8uX:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3djd | FRUCTOSYL AMINE:OXYGENOXIDOREDUCTASE (Aspergillusfumigatus) |
PF01266(DAO) | 5 | VAL A 179PHE A 178ILE A 11LEU A 356ALA A 221 | None | 1.33A | 5fctB-3djdA:undetectable | 5fctB-3djdA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fnt | HAP PROTEIN (Plasmodiumfalciparum) |
PF00026(Asp) | 5 | PHE A 310ILE A 153LEU A 30LEU A 214ALA A 34 | None | 1.33A | 5fctB-3fntA:undetectable | 5fctB-3fntA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fqd | PROTEIN DIN1 (Schizosaccharomycespombe) |
PF08652(RAI1) | 5 | ILE B 294TRP B 261LEU B 312CYH B 102TYR B 251 | None | 1.12A | 5fctB-3fqdB:undetectable | 5fctB-3fqdB:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hoa | THERMOSTABLECARBOXYPEPTIDASE 1 (Thermusthermophilus) |
PF02074(Peptidase_M32) | 5 | PHE A 223LEU A 464LEU A 228MET A 278ALA A 281 | None | 1.12A | 5fctB-3hoaA:undetectable | 5fctB-3hoaA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i9v | NADH-QUINONEOXIDOREDUCTASESUBUNIT 4NADH-QUINONEOXIDOREDUCTASESUBUNIT 9 (Thermusthermophilus;Thermusthermophilus) |
PF00346(Complex1_49kDa)PF12838(Fer4_7) | 5 | VAL 4 324ILE 9 54LEU 9 43LEU 9 58ALA 9 60 | NoneSF4 9 184 (-4.5A)NoneSF4 9 184 ( 4.7A)None | 1.41A | 5fctB-3i9v4:undetectable | 5fctB-3i9v4:23.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kgb | THYMIDYLATE SYNTHASE1/2 (Encephalitozooncuniculi) |
PF00303(Thymidylat_synt) | 5 | VAL A 59PHE A 60CYH A 174LEU A 200TYR A 237 | None | 0.72A | 5fctB-3kgbA:36.8 | 5fctB-3kgbA:58.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kjr | DIHYDROFOLATEREDUCTASE/THYMIDYLATE SYNTHASE (Babesia bovis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 10 | LYS A 275VAL A 277ILE A 306TRP A 307LEU A 390CYH A 393LEU A 419TYR A 456MET A 507MET A 509 | NoneNoneGOL A 516 (-3.9A)GOL A 516 (-3.7A)NoneNoneNoneNoneNoneGOL A 516 (-4.0A) | 0.64A | 5fctB-3kjrA:45.3 | 5fctB-3kjrA:34.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lwz | 3-DEHYDROQUINATEDEHYDRATASE (Yersinia pestis) |
PF01220(DHquinase_II) | 5 | VAL A 35ILE A 102LEU A 119LEU A 15ALA A 80 | None | 1.23A | 5fctB-3lwzA:undetectable | 5fctB-3lwzA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ne5 | CATION EFFLUX SYSTEMPROTEIN CUSA (Escherichiacoli) |
PF00873(ACR_tran) | 5 | PHE A 906ILE A1030LEU A 533LEU A1028ALA A 977 | None | 1.39A | 5fctB-3ne5A:undetectable | 5fctB-3ne5A:15.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p8c | NCK-ASSOCIATEDPROTEIN 1 (Homo sapiens) |
PF09735(Nckap1) | 5 | VAL B 697ILE B 567LEU B 557LEU B 603ALA B 607 | None | 1.35A | 5fctB-3p8cB:undetectable | 5fctB-3p8cB:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rgw | MEMBRANE-BOUNDHYDROGENASE (NIFE)LARGE SUBUNIT HOXG (Cupriavidusnecator) |
PF00374(NiFeSe_Hases) | 5 | VAL L 337PHE L 335ILE L 326TRP L 331ALA L 424 | None | 1.40A | 5fctB-3rgwL:undetectable | 5fctB-3rgwL:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tk8 | 2,3,4,5-TETRAHYDROPYRIDINE-2,6-DICARBOXYLATEN-SUCCINYLTRANSFERASE (Burkholderiapseudomallei) |
PF00132(Hexapep)PF14602(Hexapep_2)PF14805(THDPS_N_2) | 5 | VAL A 215ILE A 223LEU A 247TYR A 287ALA A 274 | None | 1.29A | 5fctB-3tk8A:undetectable | 5fctB-3tk8A:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3um6 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | LYS A 372CYH A 490LEU A 516TYR A 553MET A 604 | NoneUMP A 611 (-3.3A)NoneUMP A 611 (-4.5A)None | 1.00A | 5fctB-3um6A:41.1 | 5fctB-3um6A:28.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3v8h | THYMIDYLATE SYNTHASE (Burkholderiathailandensis) |
PF00303(Thymidylat_synt) | 5 | LYS A 48LEU A 189CYH A 192LEU A 220TYR A 257 | NoneCIT A 400 (-4.3A)CIT A 400 (-3.3A)NoneCIT A 400 (-4.5A) | 0.79A | 5fctB-3v8hA:34.7 | 5fctB-3v8hA:34.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3v8h | THYMIDYLATE SYNTHASE (Burkholderiathailandensis) |
PF00303(Thymidylat_synt) | 5 | LYS A 48TRP A 80LEU A 189CYH A 192TYR A 257 | NoneNoneCIT A 400 (-4.3A)CIT A 400 (-3.3A)CIT A 400 (-4.5A) | 0.77A | 5fctB-3v8hA:34.7 | 5fctB-3v8hA:34.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vcy | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Aliivibriofischeri) |
PF00275(EPSP_synthase) | 5 | VAL A 162ILE A 192LEU A 183MET A 171ALA A 174 | None | 1.45A | 5fctB-3vcyA:undetectable | 5fctB-3vcyA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b98 | BETA-ALANINE--PYRUVATE TRANSAMINASE (Pseudomonasaeruginosa) |
PF00202(Aminotran_3) | 5 | VAL A 114PHE A 115LEU A 163LEU A 283ALA A 222 | None | 1.12A | 5fctB-4b98A:undetectable | 5fctB-4b98A:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bhl | ARGININE KINASE (Litopenaeusvannamei) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 5 | VAL A 35PHE A 36ILE A 54TYR A 75ALA A 69 | None | 0.94A | 5fctB-4bhlA:undetectable | 5fctB-4bhlA:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c30 | DNA HELICASE II (Deinococcusradiodurans) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 5 | VAL A 63ILE A 46LEU A 251TYR A 284ALA A 20 | None | 1.44A | 5fctB-4c30A:undetectable | 5fctB-4c30A:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cob | KYNURENINEFORMAMIDASE (Pseudomonasaeruginosa) |
PF04199(Cyclase) | 5 | VAL A 176ILE A 145LEU A 172TYR A 76ALA A 170 | None | 1.40A | 5fctB-4cobA:undetectable | 5fctB-4cobA:20.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dq1 | THYMIDYLATE SYNTHASE (Staphylococcusaureus) |
PF00303(Thymidylat_synt) | 5 | LYS A 53VAL A 55CYH A 201LEU A 227TYR A 264 | NoneNoneUMP A 501 (-3.4A)NoneUMP A 501 (-4.2A) | 0.58A | 5fctB-4dq1A:34.7 | 5fctB-4dq1A:46.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dq1 | THYMIDYLATE SYNTHASE (Staphylococcusaureus) |
PF00303(Thymidylat_synt) | 5 | LYS A 53VAL A 55LEU A 198LEU A 227TYR A 264 | NoneNoneNoneNoneUMP A 501 (-4.2A) | 0.65A | 5fctB-4dq1A:34.7 | 5fctB-4dq1A:46.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ewg | BETA-KETOACYLSYNTHASE (Paraburkholderiaphymatum) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | VAL A 258PHE A 404LEU A 373MET A 281ALA A 278 | None | 1.43A | 5fctB-4ewgA:undetectable | 5fctB-4ewgA:23.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fog | THYMIDYLATE SYNTHASE (Mycobacteriumtuberculosis) |
PF00303(Thymidylat_synt) | 7 | LYS A 48VAL A 50ILE A 79TRP A 80LEU A 143CYH A 146TYR A 209 | C2F A 302 ( 3.9A)NoneC2F A 302 (-3.3A)C2F A 302 ( 3.8A)C2F A 302 (-4.8A)UFP A 301 (-2.9A)C2F A 302 ( 4.6A) | 0.45A | 5fctB-4fogA:38.2 | 5fctB-4fogA:48.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4h0u | THYMIDYLATE SYNTHASE (Corynebacteriumglutamicum) |
PF00303(Thymidylat_synt) | 5 | LYS A 51VAL A 53CYH A 149LEU A 175TYR A 212 | NoneNoneUMP A 301 (-3.2A)NoneUMP A 301 (-4.5A) | 0.83A | 5fctB-4h0uA:36.4 | 5fctB-4h0uA:46.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hu3 | OXYGEN SENSORPROTEIN DOSP (Escherichiacoli) |
PF00563(EAL) | 5 | VAL A 794ILE A 787LEU A 572TYR A 573ALA A 631 | None | 1.33A | 5fctB-4hu3A:undetectable | 5fctB-4hu3A:20.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4iqq | THYMIDYLATE SYNTHASE (Caenorhabditiselegans) |
PF00303(Thymidylat_synt) | 5 | LYS A 79ILE A 110CYH A 197LEU A 223TYR A 260 | D16 A 402 ( 4.5A)D16 A 402 (-4.0A)UMP A 401 (-3.3A)D16 A 402 (-3.7A)D16 A 402 ( 4.2A) | 1.18A | 5fctB-4iqqA:42.3 | 5fctB-4iqqA:62.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4iqq | THYMIDYLATE SYNTHASE (Caenorhabditiselegans) |
PF00303(Thymidylat_synt) | 5 | VAL A 81ILE A 110CYH A 197LEU A 223TYR A 260 | NoneD16 A 402 (-4.0A)UMP A 401 (-3.3A)D16 A 402 (-3.7A)D16 A 402 ( 4.2A) | 0.84A | 5fctB-4iqqA:42.3 | 5fctB-4iqqA:62.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4iqq | THYMIDYLATE SYNTHASE (Caenorhabditiselegans) |
PF00303(Thymidylat_synt) | 5 | VAL A 81ILE A 110TRP A 111LEU A 194LEU A 223 | NoneD16 A 402 (-4.0A)NoneNoneD16 A 402 (-3.7A) | 0.92A | 5fctB-4iqqA:42.3 | 5fctB-4iqqA:62.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iv9 | TRYPTOPHAN2-MONOOXYGENASE (Pseudomonassavastanoi) |
PF01593(Amino_oxidase) | 5 | ILE A 551LEU A 542TYR A 507MET A 495ALA A 497 | None | 1.50A | 5fctB-4iv9A:undetectable | 5fctB-4iv9A:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kh7 | GLUTATHIONES-TRANSFERASE FAMILYPROTEIN (Salmonellaenterica) |
PF02798(GST_N)PF13410(GST_C_2) | 5 | VAL A 170PHE A 169LEU A 84MET A 204ALA A 198 | None | 1.13A | 5fctB-4kh7A:undetectable | 5fctB-4kh7A:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kry | ACETYL ESTERASE (Escherichiacoli) |
PF07859(Abhydrolase_3) | 5 | VAL A 118PHE A 88ILE A 121LEU A 125ALA A 166 | NoneNoneNoneNoneSEB A 165 ( 3.4A) | 1.26A | 5fctB-4kryA:undetectable | 5fctB-4kryA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pb6 | VP1 (Felinecalicivirus) |
PF00915(Calici_coat) | 5 | VAL A 254PHE A 256ILE A 289LEU A 652ALA A 192 | None | 1.50A | 5fctB-4pb6A:undetectable | 5fctB-4pb6A:18.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ppz | SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE (Neisseriameningitidis) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | TRP A 53LEU A 130CYH A 64LEU A 156ALA A 334 | None | 1.47A | 5fctB-4ppzA:undetectable | 5fctB-4ppzA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pr3 | 5'-METHYLTHIOADENOSINE NUCLEOSIDASE /S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE (Brucellamelitensis) |
PF01048(PNP_UDP_1) | 5 | VAL A 197LEU A 183LEU A 63MET A 13ALA A 14 | None | 1.29A | 5fctB-4pr3A:undetectable | 5fctB-4pr3A:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u2m | ZINC FINGER AND BTBDOMAIN-CONTAININGPROTEIN 17,B-CELLLYMPHOMA 6 PROTEIN (Homo sapiens) |
PF00651(BTB) | 5 | VAL A 158PHE A 166LEU A 142LEU A 173ALA A 175 | None | 1.45A | 5fctB-4u2mA:undetectable | 5fctB-4u2mA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w8y | CRISPR SYSTEM CMRSUBUNIT CMR2 (Pyrococcusfuriosus) |
PF12469(DUF3692) | 5 | VAL A 538PHE A 537LEU A 526TYR A 522ALA A 583 | None | 1.50A | 5fctB-4w8yA:undetectable | 5fctB-4w8yA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wgx | MOLINATE HYDROLASE (Gulosibactermolinativorax) |
PF01979(Amidohydro_1) | 5 | VAL A 67LEU A 59LEU A 339MET A 374ALA A 387 | None | 1.42A | 5fctB-4wgxA:undetectable | 5fctB-4wgxA:20.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xsc | THYMIDYLATE SYNTHASE (Humanalphaherpesvirus3) |
PF00303(Thymidylat_synt) | 6 | VAL A 67PHE A 68ILE A 96CYH A 183LEU A 209TYR A 246 | NoneNone1PE A1002 (-4.6A)BVP A1001 (-3.4A)NoneBVP A1001 (-4.5A) | 0.75A | 5fctB-4xscA:40.6 | 5fctB-4xscA:65.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xsc | THYMIDYLATE SYNTHASE (Humanalphaherpesvirus3) |
PF00303(Thymidylat_synt) | 6 | VAL A 67PHE A 68ILE A 96LEU A 180LEU A 209TYR A 246 | NoneNone1PE A1002 (-4.6A)BVP A1001 ( 4.5A)NoneBVP A1001 (-4.5A) | 0.80A | 5fctB-4xscA:40.6 | 5fctB-4xscA:65.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xsc | THYMIDYLATE SYNTHASE (Humanalphaherpesvirus3) |
PF00303(Thymidylat_synt) | 6 | VAL A 67PHE A 68ILE A 96TRP A 97LEU A 180LEU A 209 | NoneNone1PE A1002 (-4.6A)1PE A1002 (-4.7A)BVP A1001 ( 4.5A)None | 0.81A | 5fctB-4xscA:40.6 | 5fctB-4xscA:65.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yj1 | UNCHARACTERIZEDPROTEIN (Trypanosomabrucei) |
PF09818(ABC_ATPase) | 5 | VAL A 61ILE A 207LEU A 214CYH A 85ALA A 154 | None | 1.27A | 5fctB-4yj1A:undetectable | 5fctB-4yj1A:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zj8 | HUMAN OX1R FUSIONPROTEIN TO P.ABYSIIGLYCOGEN SYNTHASE (Homo sapiens;Pyrococcusabyssi) |
PF00001(7tm_1)PF00534(Glycos_transf_1) | 5 | PHE A 139ILE A 168TRP A 169LEU A 94ALA A 127 | NoneNoneNoneNoneSUV A2001 ( 4.5A) | 1.46A | 5fctB-4zj8A:undetectable | 5fctB-4zj8A:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a31 | ANAPHASE-PROMOTINGCOMPLEX SUBUNIT 1ANAPHASE-PROMOTINGCOMPLEX SUBUNIT 5 (Homo sapiens;Homo sapiens) |
PF12859(ANAPC1)PF12862(ANAPC5) | 5 | VAL O 267ILE A 153LEU A 187CYH A 129ALA A 171 | None | 1.44A | 5fctB-5a31O:undetectable | 5fctB-5a31O:17.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5by6 | THYMIDYLATE SYNTHASE (Trichinellaspiralis) |
PF00303(Thymidylat_synt) | 5 | VAL A 73PHE A 74CYH A 189LEU A 215TYR A 252 | NoneNoneUMP A 401 (-3.4A)NoneUMP A 401 (-4.6A) | 0.74A | 5fctB-5by6A:42.2 | 5fctB-5by6A:63.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5by6 | THYMIDYLATE SYNTHASE (Trichinellaspiralis) |
PF00303(Thymidylat_synt) | 5 | VAL A 73PHE A 74ILE A 102TRP A 103LEU A 186 | NoneNoneDTT A 402 ( 4.3A)DTT A 402 ( 4.1A)None | 0.78A | 5fctB-5by6A:42.2 | 5fctB-5by6A:63.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cxp | POSSIBLE XYLANDEGRADATION ENZYME(GLYCOSYL HYDROLASEFAMILY 30-LIKEDOMAIN AND RICINB-LIKE DOMAIN) (Clostridiumacetobutylicum) |
PF02055(Glyco_hydro_30) | 5 | VAL A 261ILE A 176TYR A 216MET A 257ALA A 219 | None | 1.47A | 5fctB-5cxpA:undetectable | 5fctB-5cxpA:19.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5h3a | ORF70 (Humangammaherpesvirus8) |
PF00303(Thymidylat_synt) | 5 | VAL A 103PHE A 104ILE A 132CYH A 219TYR A 282 | NoneD16 A 401 (-3.6A)D16 A 401 ( 4.0A)UMP A 402 (-3.4A)UMP A 402 (-4.5A) | 0.73A | 5fctB-5h3aA:43.0 | 5fctB-5h3aA:71.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5h3a | ORF70 (Humangammaherpesvirus8) |
PF00303(Thymidylat_synt) | 5 | VAL A 103PHE A 104ILE A 132LEU A 216TYR A 282 | NoneD16 A 401 (-3.6A)D16 A 401 ( 4.0A)NoneUMP A 402 (-4.5A) | 0.83A | 5fctB-5h3aA:43.0 | 5fctB-5h3aA:71.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5h3a | ORF70 (Humangammaherpesvirus8) |
PF00303(Thymidylat_synt) | 5 | VAL A 103PHE A 104ILE A 132TRP A 133LEU A 216 | NoneD16 A 401 (-3.6A)D16 A 401 ( 4.0A)NoneNone | 0.70A | 5fctB-5h3aA:43.0 | 5fctB-5h3aA:71.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ht7 | UNCHARACTERIZEDPROTEIN (Methanothrixthermoacetophila) |
PF00030(Crystall) | 5 | VAL A 39PHE A 60ILE A 68LEU A 4ALA A 32 | None | 1.49A | 5fctB-5ht7A:undetectable | 5fctB-5ht7A:15.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i2h | O-METHYLTRANSFERASEFAMILY 2 (Planctopiruslimnophila) |
PF00891(Methyltransf_2)PF16864(Dimerisation2) | 5 | VAL A 96LEU A 316LEU A 76MET A 74ALA A 73 | None | 1.26A | 5fctB-5i2hA:undetectable | 5fctB-5i2hA:24.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ik2 | ATP SYNTHASE SUBUNITALPHA (Caldalkalibacillusthermarum) |
PF00006(ATP-synt_ab)PF00306(ATP-synt_ab_C)PF02874(ATP-synt_ab_N) | 5 | ILE A 129LEU A 52MET A 60MET A 62ALA A 63 | None | 1.24A | 5fctB-5ik2A:undetectable | 5fctB-5ik2A:21.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5j7w | THYMIDYLATE SYNTHASE (Enterococcusfaecalis) |
PF00303(Thymidylat_synt) | 5 | LYS A 49VAL A 51CYH A 197LEU A 223TYR A 260 | NoneNoneSO4 A 401 ( 3.9A)NoneNone | 0.62A | 5fctB-5j7wA:34.5 | 5fctB-5j7wA:48.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lkd | GLUTATHIONES-TRANSFERASEOMEGA-LIKE 2 (Saccharomycescerevisiae) |
PF13409(GST_N_2)PF13410(GST_C_2) | 5 | VAL A 158ILE A 177LEU A 199LEU A 53ALA A 57 | GSH A 401 (-4.0A)NoneNoneNoneNone | 1.33A | 5fctB-5lkdA:undetectable | 5fctB-5lkdA:21.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t0l | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Toxoplasmagondii) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 12 | LYS A 371VAL A 373PHE A 374ILE A 402TRP A 403LEU A 486CYH A 489LEU A 516TYR A 553MET A 606MET A 608ALA A 609 | CB3 A 703 (-3.2A)CB3 A 703 ( 3.6A)NoneCB3 A 703 (-3.4A)CB3 A 703 (-4.1A)UMP A 701 (-4.7A)UMP A 701 (-2.9A)CB3 A 703 (-3.7A)UMP A 701 (-4.4A)NoneCB3 A 703 (-3.6A)CB3 A 703 (-3.8A) | 0.50A | 5fctB-5t0lA:45.5 | 5fctB-5t0lA:35.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x9o | B-CELL LYMPHOMA 6PROTEIN (Homo sapiens) |
PF00651(BTB) | 5 | VAL A 35PHE A 43LEU A 19LEU A 50ALA A 52 | None | 1.40A | 5fctB-5x9oA:undetectable | 5fctB-5x9oA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6azt | ASPARAGINYLENDOPEPTIDASE 1 (Helianthusannuus) |
no annotation | 5 | VAL A 98ILE A 171LEU A 234LEU A 173ALA A 238 | None | 1.49A | 5fctB-6aztA:undetectable | 5fctB-6aztA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cdz | THYMIDYLATE SYNTHASE (Escherichiacoli) |
no annotation | 6 | LYS A 48ILE A 79LEU A 143CYH A 146LEU A 172TYR A 209 | CB3 A 701 ( 4.8A)CB3 A 701 (-3.9A)NoneUMP A 702 (-3.4A)CB3 A 701 (-3.5A)UMP A 702 ( 4.2A) | 1.06A | 5fctB-6cdzA:37.7 | 5fctB-6cdzA:undetectable |