SIMILAR PATTERNS OF AMINO ACIDS FOR 5FCT_B_C2FB402_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ci7 PROTEIN (THYMIDYLATE
SYNTHASE)


(Pneumocystis
carinii)
PF00303
(Thymidylat_synt)
6 LYS A  55
VAL A  57
PHE A  58
LEU A 205
TYR A 242
MET A 293
CB3  A 768 ( 4.9A)
CB3  A 768 ( 4.0A)
CB3  A 768 (-3.6A)
CB3  A 768 ( 4.4A)
CB3  A 768 ( 4.7A)
None
1.14A 5fctB-1ci7A:
44.0
5fctB-1ci7A:
58.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ci7 PROTEIN (THYMIDYLATE
SYNTHASE)


(Pneumocystis
carinii)
PF00303
(Thymidylat_synt)
9 VAL A  57
PHE A  58
ILE A  86
LEU A 170
CYH A 173
LEU A 205
TYR A 242
MET A 293
MET A 295
CB3  A 768 ( 4.0A)
CB3  A 768 (-3.6A)
CB3  A 768 (-3.6A)
UMP  A 767 (-4.7A)
UMP  A 767 (-1.9A)
CB3  A 768 ( 4.4A)
CB3  A 768 ( 4.7A)
None
CB3  A 768 (-3.8A)
0.68A 5fctB-1ci7A:
44.0
5fctB-1ci7A:
58.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ci7 PROTEIN (THYMIDYLATE
SYNTHASE)


(Pneumocystis
carinii)
PF00303
(Thymidylat_synt)
9 VAL A  57
PHE A  58
ILE A  86
TRP A  87
LEU A 170
LEU A 205
TYR A 242
MET A 293
MET A 295
CB3  A 768 ( 4.0A)
CB3  A 768 (-3.6A)
CB3  A 768 (-3.6A)
None
UMP  A 767 (-4.7A)
CB3  A 768 ( 4.4A)
CB3  A 768 ( 4.7A)
None
CB3  A 768 (-3.8A)
0.68A 5fctB-1ci7A:
44.0
5fctB-1ci7A:
58.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5a POLY(A) POLYMERASE

(Bos taurus)
PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central)
5 VAL A 275
PHE A 273
ILE A 227
LEU A 105
LEU A 252
None
1.11A 5fctB-1f5aA:
0.0
5fctB-1f5aA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE


(Pseudomonas
stutzeri)
PF00128
(Alpha-amylase)
PF09081
(DUF1921)
5 VAL A 330
PHE A  51
LEU A  95
LEU A 110
ALA A 187
None
1.19A 5fctB-1gcyA:
0.0
5fctB-1gcyA:
19.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvy THYMIDYLATE SYNTHASE

(Homo sapiens)
PF00303
(Thymidylat_synt)
12 LYS A  77
VAL A  79
PHE A  80
ILE A 108
TRP A 109
LEU A 192
CYH A 195
LEU A 221
TYR A 258
MET A 309
MET A 311
ALA A 312
D16  A 414 ( 4.3A)
None
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
UMP  A 314 (-1.8A)
D16  A 414 (-4.0A)
UMP  A 314 ( 4.4A)
None
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
0.61A 5fctB-1hvyA:
48.2
5fctB-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j3j BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Plasmodium
falciparum)
PF00303
(Thymidylat_synt)
5 LYS C 372
CYH C 490
LEU C 516
TYR C 553
MET C 604
None
UMP  C 611 (-3.5A)
None
UMP  C 611 (-4.9A)
None
0.96A 5fctB-1j3jC:
41.0
5fctB-1j3jC:
50.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER


(Escherichia
coli)
PF07690
(MFS_1)
5 PHE A 195
ILE A 198
LEU A  96
LEU A  43
ALA A  39
None
1.35A 5fctB-1pw4A:
0.0
5fctB-1pw4A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965


(Mycobacterium
tuberculosis)
PF01068
(DNA_ligase_A_M)
PF04679
(DNA_ligase_A_C)
5 VAL A 592
PHE A 559
CYH A 606
LEU A 595
ALA A 473
None
APK  A 481 ( 3.4A)
None
None
None
1.50A 5fctB-1vs0A:
0.0
5fctB-1vs0A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdu TRAS1 ORF2P

(Bombyx mori)
PF14529
(Exo_endo_phos_2)
5 VAL A 233
ILE A  54
LEU A 122
LEU A  26
ALA A  50
None
1.21A 5fctB-1wduA:
0.6
5fctB-1wduA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkp FLOWERING LOCUS T
PROTEIN


(Arabidopsis
thaliana)
PF01161
(PBP)
5 PHE A  22
ILE A 123
LEU A  86
LEU A 153
TYR A 151
None
1.45A 5fctB-1wkpA:
0.0
5fctB-1wkpA:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans)
PF00303
(Thymidylat_synt)
11 LYS A  69
VAL A  71
PHE A  72
ILE A 100
TRP A 101
LEU A 184
CYH A 187
LEU A 222
TYR A 259
MET A 313
MET A 315
CB3  A2351 ( 4.1A)
None
CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
UMP  A 350 (-1.8A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 4.3A)
None
CB3  A2351 (-3.4A)
0.37A 5fctB-2aazA:
undetectable
5fctB-2aazA:
59.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkl PROLYL ENDOPEPTIDASE

(Myxococcus
xanthus)
PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N)
5 VAL A 434
PHE A 384
ILE A 468
LEU A  59
LEU A 449
None
1.46A 5fctB-2bklA:
undetectable
5fctB-2bklA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f07 YVDT

(Bacillus
subtilis)
PF00440
(TetR_N)
5 PHE A  92
ILE A 183
LEU A 191
LEU A  87
ALA A 152
None
1.30A 5fctB-2f07A:
undetectable
5fctB-2f07A:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Trypanosoma
cruzi)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
5 LYS A 285
PHE A 288
ILE A 316
LEU A 429
TYR A 466
None
None
None
None
DU  A 611 (-4.6A)
1.24A 5fctB-2h2qA:
40.0
5fctB-2h2qA:
39.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Trypanosoma
cruzi)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
6 VAL A 287
PHE A 288
ILE A 316
CYH A 403
LEU A 429
TYR A 466
None
None
None
DU  A 611 (-3.7A)
None
DU  A 611 (-4.6A)
1.01A 5fctB-2h2qA:
40.0
5fctB-2h2qA:
39.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Trypanosoma
cruzi)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
5 VAL A 287
PHE A 288
ILE A 316
TRP A 317
LEU A 400
None
0.52A 5fctB-2h2qA:
40.0
5fctB-2h2qA:
39.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h63 BILIVERDIN REDUCTASE
A


(Homo sapiens)
PF01408
(GFO_IDH_MocA)
PF09166
(Biliv-reduc_cat)
5 VAL A  70
PHE A  87
ILE A  73
LEU A 121
ALA A 107
None
1.48A 5fctB-2h63A:
undetectable
5fctB-2h63A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o62 HYPOTHETICAL PROTEIN

(Nostoc
punctiforme)
PF12204
(DUF3598)
5 VAL A  66
PHE A  63
TRP A  15
LEU A 126
LEU A   9
None
1.41A 5fctB-2o62A:
undetectable
5fctB-2o62A:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR


(Cryptosporidium
hominis)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
11 LYS A 284
VAL A 286
ILE A 315
TRP A 316
LEU A 399
CYH A 402
LEU A 429
TYR A 466
MET A 517
MET A 519
ALA A 520
CB3  A 604 ( 4.7A)
None
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
UMP  A 603 ( 3.0A)
CB3  A 604 ( 4.4A)
UMP  A 603 ( 4.3A)
None
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
0.53A 5fctB-2oipA:
44.9
5fctB-2oipA:
34.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0n HYPOTHETICAL PROTEIN
NMB1532


(Neisseria
meningitidis)
PF01814
(Hemerythrin)
5 VAL A 130
ILE A  55
LEU A  49
CYH A  44
ALA A 111
None
1.18A 5fctB-2p0nA:
undetectable
5fctB-2p0nA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B


(Saccharomyces
cerevisiae)
PF16846
(Cep3)
5 ILE A 239
LEU A 256
CYH A 260
LEU A 162
TYR A 158
None
1.38A 5fctB-2quqA:
undetectable
5fctB-2quqA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv5 UNCHARACTERIZED
PROTEIN ATU2773


(Agrobacterium
fabrum)
PF04748
(Polysacc_deac_2)
5 PHE A 303
ILE A 296
LEU A 229
MET A 265
ALA A 266
None
1.38A 5fctB-2qv5A:
undetectable
5fctB-2qv5A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2riu 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE


(Candida
albicans)
PF00926
(DHBP_synthase)
5 VAL A  51
LEU A  72
CYH A  91
MET A  37
ALA A 161
None
1.26A 5fctB-2riuA:
undetectable
5fctB-2riuA:
23.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2tdd THYMIDYLATE SYNTHASE

(Lactobacillus
casei)
PF00303
(Thymidylat_synt)
6 LYS A  50
VAL A  52
ILE A  81
TRP A  82
LEU A 195
CYH A 198
THF  A 568 ( 4.7A)
None
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
THF  A 568 (-4.6A)
UFP  A 529 (-3.0A)
0.98A 5fctB-2tddA:
34.7
5fctB-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2tdd THYMIDYLATE SYNTHASE

(Lactobacillus
casei)
PF00303
(Thymidylat_synt)
6 LYS A  50
VAL A  52
LEU A 195
CYH A 198
LEU A 224
TYR A 261
THF  A 568 ( 4.7A)
None
THF  A 568 (-4.6A)
UFP  A 529 (-3.0A)
THF  A 568 (-3.6A)
UFP  A 529 (-4.7A)
0.99A 5fctB-2tddA:
34.7
5fctB-2tddA:
43.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wj3 1-H-3-HYDROXY-4-OXOQ
UINALDINE
2,4-DIOXYGENASE


(Paenarthrobacter
nitroguajacolicus)
PF00561
(Abhydrolase_1)
5 VAL A  42
ILE A  19
LEU A  90
LEU A  32
ALA A  29
None
1.43A 5fctB-2wj3A:
undetectable
5fctB-2wj3A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE


(Pseudomonas
putida)
PF00202
(Aminotran_3)
5 VAL X 113
PHE X 114
LEU X 162
LEU X 283
ALA X 222
None
1.03A 5fctB-3a8uX:
undetectable
5fctB-3a8uX:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djd FRUCTOSYL AMINE:
OXYGEN
OXIDOREDUCTASE


(Aspergillus
fumigatus)
PF01266
(DAO)
5 VAL A 179
PHE A 178
ILE A  11
LEU A 356
ALA A 221
None
1.33A 5fctB-3djdA:
undetectable
5fctB-3djdA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnt HAP PROTEIN

(Plasmodium
falciparum)
PF00026
(Asp)
5 PHE A 310
ILE A 153
LEU A  30
LEU A 214
ALA A  34
None
1.33A 5fctB-3fntA:
undetectable
5fctB-3fntA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd PROTEIN DIN1

(Schizosaccharomyces
pombe)
PF08652
(RAI1)
5 ILE B 294
TRP B 261
LEU B 312
CYH B 102
TYR B 251
None
1.12A 5fctB-3fqdB:
undetectable
5fctB-3fqdB:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1


(Thermus
thermophilus)
PF02074
(Peptidase_M32)
5 PHE A 223
LEU A 464
LEU A 228
MET A 278
ALA A 281
None
1.12A 5fctB-3hoaA:
undetectable
5fctB-3hoaA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 9


(Thermus
thermophilus;
Thermus
thermophilus)
PF00346
(Complex1_49kDa)
PF12838
(Fer4_7)
5 VAL 4 324
ILE 9  54
LEU 9  43
LEU 9  58
ALA 9  60
None
SF4  9 184 (-4.5A)
None
SF4  9 184 ( 4.7A)
None
1.41A 5fctB-3i9v4:
undetectable
5fctB-3i9v4:
23.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kgb THYMIDYLATE SYNTHASE
1/2


(Encephalitozoon
cuniculi)
PF00303
(Thymidylat_synt)
5 VAL A  59
PHE A  60
CYH A 174
LEU A 200
TYR A 237
None
0.72A 5fctB-3kgbA:
36.8
5fctB-3kgbA:
58.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE


(Babesia bovis)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
10 LYS A 275
VAL A 277
ILE A 306
TRP A 307
LEU A 390
CYH A 393
LEU A 419
TYR A 456
MET A 507
MET A 509
None
None
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
GOL  A 516 (-4.0A)
0.64A 5fctB-3kjrA:
45.3
5fctB-3kjrA:
34.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwz 3-DEHYDROQUINATE
DEHYDRATASE


(Yersinia pestis)
PF01220
(DHquinase_II)
5 VAL A  35
ILE A 102
LEU A 119
LEU A  15
ALA A  80
None
1.23A 5fctB-3lwzA:
undetectable
5fctB-3lwzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA


(Escherichia
coli)
PF00873
(ACR_tran)
5 PHE A 906
ILE A1030
LEU A 533
LEU A1028
ALA A 977
None
1.39A 5fctB-3ne5A:
undetectable
5fctB-3ne5A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1


(Homo sapiens)
PF09735
(Nckap1)
5 VAL B 697
ILE B 567
LEU B 557
LEU B 603
ALA B 607
None
1.35A 5fctB-3p8cB:
undetectable
5fctB-3p8cB:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG


(Cupriavidus
necator)
PF00374
(NiFeSe_Hases)
5 VAL L 337
PHE L 335
ILE L 326
TRP L 331
ALA L 424
None
1.40A 5fctB-3rgwL:
undetectable
5fctB-3rgwL:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E


(Burkholderia
pseudomallei)
PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2)
5 VAL A 215
ILE A 223
LEU A 247
TYR A 287
ALA A 274
None
1.29A 5fctB-3tk8A:
undetectable
5fctB-3tk8A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Plasmodium
falciparum)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
5 LYS A 372
CYH A 490
LEU A 516
TYR A 553
MET A 604
None
UMP  A 611 (-3.3A)
None
UMP  A 611 (-4.5A)
None
1.00A 5fctB-3um6A:
41.1
5fctB-3um6A:
28.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v8h THYMIDYLATE SYNTHASE

(Burkholderia
thailandensis)
PF00303
(Thymidylat_synt)
5 LYS A  48
LEU A 189
CYH A 192
LEU A 220
TYR A 257
None
CIT  A 400 (-4.3A)
CIT  A 400 (-3.3A)
None
CIT  A 400 (-4.5A)
0.79A 5fctB-3v8hA:
34.7
5fctB-3v8hA:
34.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v8h THYMIDYLATE SYNTHASE

(Burkholderia
thailandensis)
PF00303
(Thymidylat_synt)
5 LYS A  48
TRP A  80
LEU A 189
CYH A 192
TYR A 257
None
None
CIT  A 400 (-4.3A)
CIT  A 400 (-3.3A)
CIT  A 400 (-4.5A)
0.77A 5fctB-3v8hA:
34.7
5fctB-3v8hA:
34.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Aliivibrio
fischeri)
PF00275
(EPSP_synthase)
5 VAL A 162
ILE A 192
LEU A 183
MET A 171
ALA A 174
None
1.45A 5fctB-3vcyA:
undetectable
5fctB-3vcyA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE


(Pseudomonas
aeruginosa)
PF00202
(Aminotran_3)
5 VAL A 114
PHE A 115
LEU A 163
LEU A 283
ALA A 222
None
1.12A 5fctB-4b98A:
undetectable
5fctB-4b98A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhl ARGININE KINASE

(Litopenaeus
vannamei)
PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN)
5 VAL A  35
PHE A  36
ILE A  54
TYR A  75
ALA A  69
None
0.94A 5fctB-4bhlA:
undetectable
5fctB-4bhlA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
5 VAL A  63
ILE A  46
LEU A 251
TYR A 284
ALA A  20
None
1.44A 5fctB-4c30A:
undetectable
5fctB-4c30A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cob KYNURENINE
FORMAMIDASE


(Pseudomonas
aeruginosa)
PF04199
(Cyclase)
5 VAL A 176
ILE A 145
LEU A 172
TYR A  76
ALA A 170
None
1.40A 5fctB-4cobA:
undetectable
5fctB-4cobA:
20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dq1 THYMIDYLATE SYNTHASE

(Staphylococcus
aureus)
PF00303
(Thymidylat_synt)
5 LYS A  53
VAL A  55
CYH A 201
LEU A 227
TYR A 264
None
None
UMP  A 501 (-3.4A)
None
UMP  A 501 (-4.2A)
0.58A 5fctB-4dq1A:
34.7
5fctB-4dq1A:
46.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dq1 THYMIDYLATE SYNTHASE

(Staphylococcus
aureus)
PF00303
(Thymidylat_synt)
5 LYS A  53
VAL A  55
LEU A 198
LEU A 227
TYR A 264
None
None
None
None
UMP  A 501 (-4.2A)
0.65A 5fctB-4dq1A:
34.7
5fctB-4dq1A:
46.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewg BETA-KETOACYL
SYNTHASE


(Paraburkholderia
phymatum)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 VAL A 258
PHE A 404
LEU A 373
MET A 281
ALA A 278
None
1.43A 5fctB-4ewgA:
undetectable
5fctB-4ewgA:
23.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fog THYMIDYLATE SYNTHASE

(Mycobacterium
tuberculosis)
PF00303
(Thymidylat_synt)
7 LYS A  48
VAL A  50
ILE A  79
TRP A  80
LEU A 143
CYH A 146
TYR A 209
C2F  A 302 ( 3.9A)
None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
UFP  A 301 (-2.9A)
C2F  A 302 ( 4.6A)
0.45A 5fctB-4fogA:
38.2
5fctB-4fogA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h0u THYMIDYLATE SYNTHASE

(Corynebacterium
glutamicum)
PF00303
(Thymidylat_synt)
5 LYS A  51
VAL A  53
CYH A 149
LEU A 175
TYR A 212
None
None
UMP  A 301 (-3.2A)
None
UMP  A 301 (-4.5A)
0.83A 5fctB-4h0uA:
36.4
5fctB-4h0uA:
46.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu3 OXYGEN SENSOR
PROTEIN DOSP


(Escherichia
coli)
PF00563
(EAL)
5 VAL A 794
ILE A 787
LEU A 572
TYR A 573
ALA A 631
None
1.33A 5fctB-4hu3A:
undetectable
5fctB-4hu3A:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqq THYMIDYLATE SYNTHASE

(Caenorhabditis
elegans)
PF00303
(Thymidylat_synt)
5 LYS A  79
ILE A 110
CYH A 197
LEU A 223
TYR A 260
D16  A 402 ( 4.5A)
D16  A 402 (-4.0A)
UMP  A 401 (-3.3A)
D16  A 402 (-3.7A)
D16  A 402 ( 4.2A)
1.18A 5fctB-4iqqA:
42.3
5fctB-4iqqA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqq THYMIDYLATE SYNTHASE

(Caenorhabditis
elegans)
PF00303
(Thymidylat_synt)
5 VAL A  81
ILE A 110
CYH A 197
LEU A 223
TYR A 260
None
D16  A 402 (-4.0A)
UMP  A 401 (-3.3A)
D16  A 402 (-3.7A)
D16  A 402 ( 4.2A)
0.84A 5fctB-4iqqA:
42.3
5fctB-4iqqA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqq THYMIDYLATE SYNTHASE

(Caenorhabditis
elegans)
PF00303
(Thymidylat_synt)
5 VAL A  81
ILE A 110
TRP A 111
LEU A 194
LEU A 223
None
D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
0.92A 5fctB-4iqqA:
42.3
5fctB-4iqqA:
62.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE


(Pseudomonas
savastanoi)
PF01593
(Amino_oxidase)
5 ILE A 551
LEU A 542
TYR A 507
MET A 495
ALA A 497
None
1.50A 5fctB-4iv9A:
undetectable
5fctB-4iv9A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh7 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN


(Salmonella
enterica)
PF02798
(GST_N)
PF13410
(GST_C_2)
5 VAL A 170
PHE A 169
LEU A  84
MET A 204
ALA A 198
None
1.13A 5fctB-4kh7A:
undetectable
5fctB-4kh7A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kry ACETYL ESTERASE

(Escherichia
coli)
PF07859
(Abhydrolase_3)
5 VAL A 118
PHE A  88
ILE A 121
LEU A 125
ALA A 166
None
None
None
None
SEB  A 165 ( 3.4A)
1.26A 5fctB-4kryA:
undetectable
5fctB-4kryA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pb6 VP1

(Feline
calicivirus)
PF00915
(Calici_coat)
5 VAL A 254
PHE A 256
ILE A 289
LEU A 652
ALA A 192
None
1.50A 5fctB-4pb6A:
undetectable
5fctB-4pb6A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE


(Neisseria
meningitidis)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 TRP A  53
LEU A 130
CYH A  64
LEU A 156
ALA A 334
None
1.47A 5fctB-4ppzA:
undetectable
5fctB-4ppzA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pr3 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE


(Brucella
melitensis)
PF01048
(PNP_UDP_1)
5 VAL A 197
LEU A 183
LEU A  63
MET A  13
ALA A  14
None
1.29A 5fctB-4pr3A:
undetectable
5fctB-4pr3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2m ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,B-CELL
LYMPHOMA 6 PROTEIN


(Homo sapiens)
PF00651
(BTB)
5 VAL A 158
PHE A 166
LEU A 142
LEU A 173
ALA A 175
None
1.45A 5fctB-4u2mA:
undetectable
5fctB-4u2mA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2


(Pyrococcus
furiosus)
PF12469
(DUF3692)
5 VAL A 538
PHE A 537
LEU A 526
TYR A 522
ALA A 583
None
1.50A 5fctB-4w8yA:
undetectable
5fctB-4w8yA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgx MOLINATE HYDROLASE

(Gulosibacter
molinativorax)
PF01979
(Amidohydro_1)
5 VAL A  67
LEU A  59
LEU A 339
MET A 374
ALA A 387
None
1.42A 5fctB-4wgxA:
undetectable
5fctB-4wgxA:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xsc THYMIDYLATE SYNTHASE

(Human
alphaherpesvirus
3)
PF00303
(Thymidylat_synt)
6 VAL A  67
PHE A  68
ILE A  96
CYH A 183
LEU A 209
TYR A 246
None
None
1PE  A1002 (-4.6A)
BVP  A1001 (-3.4A)
None
BVP  A1001 (-4.5A)
0.75A 5fctB-4xscA:
40.6
5fctB-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xsc THYMIDYLATE SYNTHASE

(Human
alphaherpesvirus
3)
PF00303
(Thymidylat_synt)
6 VAL A  67
PHE A  68
ILE A  96
LEU A 180
LEU A 209
TYR A 246
None
None
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-4.5A)
0.80A 5fctB-4xscA:
40.6
5fctB-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xsc THYMIDYLATE SYNTHASE

(Human
alphaherpesvirus
3)
PF00303
(Thymidylat_synt)
6 VAL A  67
PHE A  68
ILE A  96
TRP A  97
LEU A 180
LEU A 209
None
None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
0.81A 5fctB-4xscA:
40.6
5fctB-4xscA:
65.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN


(Trypanosoma
brucei)
PF09818
(ABC_ATPase)
5 VAL A  61
ILE A 207
LEU A 214
CYH A  85
ALA A 154
None
1.27A 5fctB-4yj1A:
undetectable
5fctB-4yj1A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE


(Homo sapiens;
Pyrococcus
abyssi)
PF00001
(7tm_1)
PF00534
(Glycos_transf_1)
5 PHE A 139
ILE A 168
TRP A 169
LEU A  94
ALA A 127
None
None
None
None
SUV  A2001 ( 4.5A)
1.46A 5fctB-4zj8A:
undetectable
5fctB-4zj8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5


(Homo sapiens;
Homo sapiens)
PF12859
(ANAPC1)
PF12862
(ANAPC5)
5 VAL O 267
ILE A 153
LEU A 187
CYH A 129
ALA A 171
None
1.44A 5fctB-5a31O:
undetectable
5fctB-5a31O:
17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5by6 THYMIDYLATE SYNTHASE

(Trichinella
spiralis)
PF00303
(Thymidylat_synt)
5 VAL A  73
PHE A  74
CYH A 189
LEU A 215
TYR A 252
None
None
UMP  A 401 (-3.4A)
None
UMP  A 401 (-4.6A)
0.74A 5fctB-5by6A:
42.2
5fctB-5by6A:
63.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5by6 THYMIDYLATE SYNTHASE

(Trichinella
spiralis)
PF00303
(Thymidylat_synt)
5 VAL A  73
PHE A  74
ILE A 102
TRP A 103
LEU A 186
None
None
DTT  A 402 ( 4.3A)
DTT  A 402 ( 4.1A)
None
0.78A 5fctB-5by6A:
42.2
5fctB-5by6A:
63.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)


(Clostridium
acetobutylicum)
PF02055
(Glyco_hydro_30)
5 VAL A 261
ILE A 176
TYR A 216
MET A 257
ALA A 219
None
1.47A 5fctB-5cxpA:
undetectable
5fctB-5cxpA:
19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h3a ORF70

(Human
gammaherpesvirus
8)
PF00303
(Thymidylat_synt)
5 VAL A 103
PHE A 104
ILE A 132
CYH A 219
TYR A 282
None
D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
UMP  A 402 (-3.4A)
UMP  A 402 (-4.5A)
0.73A 5fctB-5h3aA:
43.0
5fctB-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h3a ORF70

(Human
gammaherpesvirus
8)
PF00303
(Thymidylat_synt)
5 VAL A 103
PHE A 104
ILE A 132
LEU A 216
TYR A 282
None
D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
UMP  A 402 (-4.5A)
0.83A 5fctB-5h3aA:
43.0
5fctB-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h3a ORF70

(Human
gammaherpesvirus
8)
PF00303
(Thymidylat_synt)
5 VAL A 103
PHE A 104
ILE A 132
TRP A 133
LEU A 216
None
D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
None
0.70A 5fctB-5h3aA:
43.0
5fctB-5h3aA:
71.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ht7 UNCHARACTERIZED
PROTEIN


(Methanothrix
thermoacetophila)
PF00030
(Crystall)
5 VAL A  39
PHE A  60
ILE A  68
LEU A   4
ALA A  32
None
1.49A 5fctB-5ht7A:
undetectable
5fctB-5ht7A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2


(Planctopirus
limnophila)
PF00891
(Methyltransf_2)
PF16864
(Dimerisation2)
5 VAL A  96
LEU A 316
LEU A  76
MET A  74
ALA A  73
None
1.26A 5fctB-5i2hA:
undetectable
5fctB-5i2hA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE SUBUNIT
ALPHA


(Caldalkalibacillus
thermarum)
PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N)
5 ILE A 129
LEU A  52
MET A  60
MET A  62
ALA A  63
None
1.24A 5fctB-5ik2A:
undetectable
5fctB-5ik2A:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j7w THYMIDYLATE SYNTHASE

(Enterococcus
faecalis)
PF00303
(Thymidylat_synt)
5 LYS A  49
VAL A  51
CYH A 197
LEU A 223
TYR A 260
None
None
SO4  A 401 ( 3.9A)
None
None
0.62A 5fctB-5j7wA:
34.5
5fctB-5j7wA:
48.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2


(Saccharomyces
cerevisiae)
PF13409
(GST_N_2)
PF13410
(GST_C_2)
5 VAL A 158
ILE A 177
LEU A 199
LEU A  53
ALA A  57
GSH  A 401 (-4.0A)
None
None
None
None
1.33A 5fctB-5lkdA:
undetectable
5fctB-5lkdA:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Toxoplasma
gondii)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
12 LYS A 371
VAL A 373
PHE A 374
ILE A 402
TRP A 403
LEU A 486
CYH A 489
LEU A 516
TYR A 553
MET A 606
MET A 608
ALA A 609
CB3  A 703 (-3.2A)
CB3  A 703 ( 3.6A)
None
CB3  A 703 (-3.4A)
CB3  A 703 (-4.1A)
UMP  A 701 (-4.7A)
UMP  A 701 (-2.9A)
CB3  A 703 (-3.7A)
UMP  A 701 (-4.4A)
None
CB3  A 703 (-3.6A)
CB3  A 703 (-3.8A)
0.50A 5fctB-5t0lA:
45.5
5fctB-5t0lA:
35.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9o B-CELL LYMPHOMA 6
PROTEIN


(Homo sapiens)
PF00651
(BTB)
5 VAL A  35
PHE A  43
LEU A  19
LEU A  50
ALA A  52
None
1.40A 5fctB-5x9oA:
undetectable
5fctB-5x9oA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azt ASPARAGINYL
ENDOPEPTIDASE 1


(Helianthus
annuus)
no annotation 5 VAL A  98
ILE A 171
LEU A 234
LEU A 173
ALA A 238
None
1.49A 5fctB-6aztA:
undetectable
5fctB-6aztA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cdz THYMIDYLATE SYNTHASE

(Escherichia
coli)
no annotation 6 LYS A  48
ILE A  79
LEU A 143
CYH A 146
LEU A 172
TYR A 209
CB3  A 701 ( 4.8A)
CB3  A 701 (-3.9A)
None
UMP  A 702 (-3.4A)
CB3  A 701 (-3.5A)
UMP  A 702 ( 4.2A)
1.06A 5fctB-6cdzA:
37.7
5fctB-6cdzA:
undetectable