SIMILAR PATTERNS OF AMINO ACIDS FOR 5FCT_B_C2FB402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ci7 PROTEIN (THYMIDYLATE
SYNTHASE)

(Pneumocystis
carinii) 		PF00303
(Thymidylat_synt) 		6 LYS A  55
VAL A  57
PHE A  58
LEU A 205
TYR A 242
MET A 293
 CB3  A 768 ( 4.9A)
CB3  A 768 ( 4.0A)
CB3  A 768 (-3.6A)
CB3  A 768 ( 4.4A)
CB3  A 768 ( 4.7A)
None
 1.14A 5fctB-1ci7A:
44.0		 5fctB-1ci7A:
58.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ci7 PROTEIN (THYMIDYLATE
SYNTHASE)

(Pneumocystis
carinii) 		PF00303
(Thymidylat_synt) 		9 VAL A  57
PHE A  58
ILE A  86
LEU A 170
CYH A 173
LEU A 205
TYR A 242
MET A 293
MET A 295
 CB3  A 768 ( 4.0A)
CB3  A 768 (-3.6A)
CB3  A 768 (-3.6A)
UMP  A 767 (-4.7A)
UMP  A 767 (-1.9A)
CB3  A 768 ( 4.4A)
CB3  A 768 ( 4.7A)
None
CB3  A 768 (-3.8A)
 0.68A 5fctB-1ci7A:
44.0		 5fctB-1ci7A:
58.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ci7 PROTEIN (THYMIDYLATE
SYNTHASE)

(Pneumocystis
carinii) 		PF00303
(Thymidylat_synt) 		9 VAL A  57
PHE A  58
ILE A  86
TRP A  87
LEU A 170
LEU A 205
TYR A 242
MET A 293
MET A 295
 CB3  A 768 ( 4.0A)
CB3  A 768 (-3.6A)
CB3  A 768 (-3.6A)
None
UMP  A 767 (-4.7A)
CB3  A 768 ( 4.4A)
CB3  A 768 ( 4.7A)
None
CB3  A 768 (-3.8A)
 0.68A 5fctB-1ci7A:
44.0		 5fctB-1ci7A:
58.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5a POLY(A) POLYMERASE

(Bos taurus) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		5 VAL A 275
PHE A 273
ILE A 227
LEU A 105
LEU A 252
 None
 1.11A 5fctB-1f5aA:
0.0		 5fctB-1f5aA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE

(Pseudomonas
stutzeri) 		PF00128
(Alpha-amylase)
PF09081
(DUF1921) 		5 VAL A 330
PHE A  51
LEU A  95
LEU A 110
ALA A 187
 None
 1.19A 5fctB-1gcyA:
0.0		 5fctB-1gcyA:
19.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvy THYMIDYLATE SYNTHASE

(Homo sapiens) 		PF00303
(Thymidylat_synt) 		12 LYS A  77
VAL A  79
PHE A  80
ILE A 108
TRP A 109
LEU A 192
CYH A 195
LEU A 221
TYR A 258
MET A 309
MET A 311
ALA A 312
 D16  A 414 ( 4.3A)
None
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
UMP  A 314 (-1.8A)
D16  A 414 (-4.0A)
UMP  A 314 ( 4.4A)
None
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.61A 5fctB-1hvyA:
48.2		 5fctB-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j3j BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00303
(Thymidylat_synt) 		5 LYS C 372
CYH C 490
LEU C 516
TYR C 553
MET C 604
 None
UMP  C 611 (-3.5A)
None
UMP  C 611 (-4.9A)
None
 0.96A 5fctB-1j3jC:
41.0		 5fctB-1j3jC:
50.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		5 PHE A 195
ILE A 198
LEU A  96
LEU A  43
ALA A  39
 None
 1.35A 5fctB-1pw4A:
0.0		 5fctB-1pw4A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965

(Mycobacterium
tuberculosis) 		PF01068
(DNA_ligase_A_M)
PF04679
(DNA_ligase_A_C) 		5 VAL A 592
PHE A 559
CYH A 606
LEU A 595
ALA A 473
 None
APK  A 481 ( 3.4A)
None
None
None
 1.50A 5fctB-1vs0A:
0.0		 5fctB-1vs0A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdu TRAS1 ORF2P

(Bombyx mori) 		PF14529
(Exo_endo_phos_2) 		5 VAL A 233
ILE A  54
LEU A 122
LEU A  26
ALA A  50
 None
 1.21A 5fctB-1wduA:
0.6		 5fctB-1wduA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkp FLOWERING LOCUS T
PROTEIN

(Arabidopsis
thaliana) 		PF01161
(PBP) 		5 PHE A  22
ILE A 123
LEU A  86
LEU A 153
TYR A 151
 None
 1.45A 5fctB-1wkpA:
0.0		 5fctB-1wkpA:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		11 LYS A  69
VAL A  71
PHE A  72
ILE A 100
TRP A 101
LEU A 184
CYH A 187
LEU A 222
TYR A 259
MET A 313
MET A 315
 CB3  A2351 ( 4.1A)
None
CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
None
UMP  A 350 (-1.8A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 4.3A)
None
CB3  A2351 (-3.4A)
 0.37A 5fctB-2aazA:
undetectable		 5fctB-2aazA:
59.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkl PROLYL ENDOPEPTIDASE

(Myxococcus
xanthus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 VAL A 434
PHE A 384
ILE A 468
LEU A  59
LEU A 449
 None
 1.46A 5fctB-2bklA:
undetectable		 5fctB-2bklA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f07 YVDT

(Bacillus
subtilis) 		PF00440
(TetR_N) 		5 PHE A  92
ILE A 183
LEU A 191
LEU A  87
ALA A 152
 None
 1.30A 5fctB-2f07A:
undetectable		 5fctB-2f07A:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 LYS A 285
PHE A 288
ILE A 316
LEU A 429
TYR A 466
 None
None
None
None
DU  A 611 (-4.6A)
 1.24A 5fctB-2h2qA:
40.0		 5fctB-2h2qA:
39.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		6 VAL A 287
PHE A 288
ILE A 316
CYH A 403
LEU A 429
TYR A 466
 None
None
None
DU  A 611 (-3.7A)
None
DU  A 611 (-4.6A)
 1.01A 5fctB-2h2qA:
40.0		 5fctB-2h2qA:
39.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 VAL A 287
PHE A 288
ILE A 316
TRP A 317
LEU A 400
 None
 0.52A 5fctB-2h2qA:
40.0		 5fctB-2h2qA:
39.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h63 BILIVERDIN REDUCTASE
A

(Homo sapiens) 		PF01408
(GFO_IDH_MocA)
PF09166
(Biliv-reduc_cat) 		5 VAL A  70
PHE A  87
ILE A  73
LEU A 121
ALA A 107
 None
 1.48A 5fctB-2h63A:
undetectable		 5fctB-2h63A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o62 HYPOTHETICAL PROTEIN

(Nostoc
punctiforme) 		PF12204
(DUF3598) 		5 VAL A  66
PHE A  63
TRP A  15
LEU A 126
LEU A   9
 None
 1.41A 5fctB-2o62A:
undetectable		 5fctB-2o62A:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		11 LYS A 284
VAL A 286
ILE A 315
TRP A 316
LEU A 399
CYH A 402
LEU A 429
TYR A 466
MET A 517
MET A 519
ALA A 520
 CB3  A 604 ( 4.7A)
None
CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
None
UMP  A 603 ( 3.0A)
CB3  A 604 ( 4.4A)
UMP  A 603 ( 4.3A)
None
CB3  A 604 ( 3.5A)
CB3  A 604 ( 4.0A)
 0.53A 5fctB-2oipA:
44.9		 5fctB-2oipA:
34.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0n HYPOTHETICAL PROTEIN
NMB1532

(Neisseria
meningitidis) 		PF01814
(Hemerythrin) 		5 VAL A 130
ILE A  55
LEU A  49
CYH A  44
ALA A 111
 None
 1.18A 5fctB-2p0nA:
undetectable		 5fctB-2p0nA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B

(Saccharomyces
cerevisiae) 		PF16846
(Cep3) 		5 ILE A 239
LEU A 256
CYH A 260
LEU A 162
TYR A 158
 None
 1.38A 5fctB-2quqA:
undetectable		 5fctB-2quqA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv5 UNCHARACTERIZED
PROTEIN ATU2773

(Agrobacterium
fabrum) 		PF04748
(Polysacc_deac_2) 		5 PHE A 303
ILE A 296
LEU A 229
MET A 265
ALA A 266
 None
 1.38A 5fctB-2qv5A:
undetectable		 5fctB-2qv5A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2riu 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Candida
albicans) 		PF00926
(DHBP_synthase) 		5 VAL A  51
LEU A  72
CYH A  91
MET A  37
ALA A 161
 None
 1.26A 5fctB-2riuA:
undetectable		 5fctB-2riuA:
23.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2tdd THYMIDYLATE SYNTHASE

(Lactobacillus
casei) 		PF00303
(Thymidylat_synt) 		6 LYS A  50
VAL A  52
ILE A  81
TRP A  82
LEU A 195
CYH A 198
 THF  A 568 ( 4.7A)
None
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
THF  A 568 (-4.6A)
UFP  A 529 (-3.0A)
 0.98A 5fctB-2tddA:
34.7		 5fctB-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2tdd THYMIDYLATE SYNTHASE

(Lactobacillus
casei) 		PF00303
(Thymidylat_synt) 		6 LYS A  50
VAL A  52
LEU A 195
CYH A 198
LEU A 224
TYR A 261
 THF  A 568 ( 4.7A)
None
THF  A 568 (-4.6A)
UFP  A 529 (-3.0A)
THF  A 568 (-3.6A)
UFP  A 529 (-4.7A)
 0.99A 5fctB-2tddA:
34.7		 5fctB-2tddA:
43.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wj3 1-H-3-HYDROXY-4-OXOQ
UINALDINE
2,4-DIOXYGENASE

(Paenarthrobacter
nitroguajacolicus) 		PF00561
(Abhydrolase_1) 		5 VAL A  42
ILE A  19
LEU A  90
LEU A  32
ALA A  29
 None
 1.43A 5fctB-2wj3A:
undetectable		 5fctB-2wj3A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE

(Pseudomonas
putida) 		PF00202
(Aminotran_3) 		5 VAL X 113
PHE X 114
LEU X 162
LEU X 283
ALA X 222
 None
 1.03A 5fctB-3a8uX:
undetectable		 5fctB-3a8uX:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djd FRUCTOSYL AMINE:
OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		5 VAL A 179
PHE A 178
ILE A  11
LEU A 356
ALA A 221
 None
 1.33A 5fctB-3djdA:
undetectable		 5fctB-3djdA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnt HAP PROTEIN

(Plasmodium
falciparum) 		PF00026
(Asp) 		5 PHE A 310
ILE A 153
LEU A  30
LEU A 214
ALA A  34
 None
 1.33A 5fctB-3fntA:
undetectable		 5fctB-3fntA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd PROTEIN DIN1

(Schizosaccharomyces
pombe) 		PF08652
(RAI1) 		5 ILE B 294
TRP B 261
LEU B 312
CYH B 102
TYR B 251
 None
 1.12A 5fctB-3fqdB:
undetectable		 5fctB-3fqdB:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1

(Thermus
thermophilus) 		PF02074
(Peptidase_M32) 		5 PHE A 223
LEU A 464
LEU A 228
MET A 278
ALA A 281
 None
 1.12A 5fctB-3hoaA:
undetectable		 5fctB-3hoaA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 9

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00346
(Complex1_49kDa)
PF12838
(Fer4_7) 		5 VAL 4 324
ILE 9  54
LEU 9  43
LEU 9  58
ALA 9  60
 None
SF4  9 184 (-4.5A)
None
SF4  9 184 ( 4.7A)
None
 1.41A 5fctB-3i9v4:
undetectable		 5fctB-3i9v4:
23.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kgb THYMIDYLATE SYNTHASE
1/2

(Encephalitozoon
cuniculi) 		PF00303
(Thymidylat_synt) 		5 VAL A  59
PHE A  60
CYH A 174
LEU A 200
TYR A 237
 None
 0.72A 5fctB-3kgbA:
36.8		 5fctB-3kgbA:
58.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		10 LYS A 275
VAL A 277
ILE A 306
TRP A 307
LEU A 390
CYH A 393
LEU A 419
TYR A 456
MET A 507
MET A 509
 None
None
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
GOL  A 516 (-4.0A)
 0.64A 5fctB-3kjrA:
45.3		 5fctB-3kjrA:
34.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwz 3-DEHYDROQUINATE
DEHYDRATASE

(Yersinia pestis) 		PF01220
(DHquinase_II) 		5 VAL A  35
ILE A 102
LEU A 119
LEU A  15
ALA A  80
 None
 1.23A 5fctB-3lwzA:
undetectable		 5fctB-3lwzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 PHE A 906
ILE A1030
LEU A 533
LEU A1028
ALA A 977
 None
 1.39A 5fctB-3ne5A:
undetectable		 5fctB-3ne5A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		5 VAL B 697
ILE B 567
LEU B 557
LEU B 603
ALA B 607
 None
 1.35A 5fctB-3p8cB:
undetectable		 5fctB-3p8cB:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		5 VAL L 337
PHE L 335
ILE L 326
TRP L 331
ALA L 424
 None
 1.40A 5fctB-3rgwL:
undetectable		 5fctB-3rgwL:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Burkholderia
pseudomallei) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		5 VAL A 215
ILE A 223
LEU A 247
TYR A 287
ALA A 274
 None
 1.29A 5fctB-3tk8A:
undetectable		 5fctB-3tk8A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 LYS A 372
CYH A 490
LEU A 516
TYR A 553
MET A 604
 None
UMP  A 611 (-3.3A)
None
UMP  A 611 (-4.5A)
None
 1.00A 5fctB-3um6A:
41.1		 5fctB-3um6A:
28.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v8h THYMIDYLATE SYNTHASE

(Burkholderia
thailandensis) 		PF00303
(Thymidylat_synt) 		5 LYS A  48
LEU A 189
CYH A 192
LEU A 220
TYR A 257
 None
CIT  A 400 (-4.3A)
CIT  A 400 (-3.3A)
None
CIT  A 400 (-4.5A)
 0.79A 5fctB-3v8hA:
34.7		 5fctB-3v8hA:
34.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v8h THYMIDYLATE SYNTHASE

(Burkholderia
thailandensis) 		PF00303
(Thymidylat_synt) 		5 LYS A  48
TRP A  80
LEU A 189
CYH A 192
TYR A 257
 None
None
CIT  A 400 (-4.3A)
CIT  A 400 (-3.3A)
CIT  A 400 (-4.5A)
 0.77A 5fctB-3v8hA:
34.7		 5fctB-3v8hA:
34.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		5 VAL A 162
ILE A 192
LEU A 183
MET A 171
ALA A 174
 None
 1.45A 5fctB-3vcyA:
undetectable		 5fctB-3vcyA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		5 VAL A 114
PHE A 115
LEU A 163
LEU A 283
ALA A 222
 None
 1.12A 5fctB-4b98A:
undetectable		 5fctB-4b98A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhl ARGININE KINASE

(Litopenaeus
vannamei) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 VAL A  35
PHE A  36
ILE A  54
TYR A  75
ALA A  69
 None
 0.94A 5fctB-4bhlA:
undetectable		 5fctB-4bhlA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 VAL A  63
ILE A  46
LEU A 251
TYR A 284
ALA A  20
 None
 1.44A 5fctB-4c30A:
undetectable		 5fctB-4c30A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cob KYNURENINE
FORMAMIDASE

(Pseudomonas
aeruginosa) 		PF04199
(Cyclase) 		5 VAL A 176
ILE A 145
LEU A 172
TYR A  76
ALA A 170
 None
 1.40A 5fctB-4cobA:
undetectable		 5fctB-4cobA:
20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dq1 THYMIDYLATE SYNTHASE

(Staphylococcus
aureus) 		PF00303
(Thymidylat_synt) 		5 LYS A  53
VAL A  55
CYH A 201
LEU A 227
TYR A 264
 None
None
UMP  A 501 (-3.4A)
None
UMP  A 501 (-4.2A)
 0.58A 5fctB-4dq1A:
34.7		 5fctB-4dq1A:
46.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dq1 THYMIDYLATE SYNTHASE

(Staphylococcus
aureus) 		PF00303
(Thymidylat_synt) 		5 LYS A  53
VAL A  55
LEU A 198
LEU A 227
TYR A 264
 None
None
None
None
UMP  A 501 (-4.2A)
 0.65A 5fctB-4dq1A:
34.7		 5fctB-4dq1A:
46.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewg BETA-KETOACYL
SYNTHASE

(Paraburkholderia
phymatum) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A 258
PHE A 404
LEU A 373
MET A 281
ALA A 278
 None
 1.43A 5fctB-4ewgA:
undetectable		 5fctB-4ewgA:
23.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fog THYMIDYLATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00303
(Thymidylat_synt) 		7 LYS A  48
VAL A  50
ILE A  79
TRP A  80
LEU A 143
CYH A 146
TYR A 209
 C2F  A 302 ( 3.9A)
None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
UFP  A 301 (-2.9A)
C2F  A 302 ( 4.6A)
 0.45A 5fctB-4fogA:
38.2		 5fctB-4fogA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h0u THYMIDYLATE SYNTHASE

(Corynebacterium
glutamicum) 		PF00303
(Thymidylat_synt) 		5 LYS A  51
VAL A  53
CYH A 149
LEU A 175
TYR A 212
 None
None
UMP  A 301 (-3.2A)
None
UMP  A 301 (-4.5A)
 0.83A 5fctB-4h0uA:
36.4		 5fctB-4h0uA:
46.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu3 OXYGEN SENSOR
PROTEIN DOSP

(Escherichia
coli) 		PF00563
(EAL) 		5 VAL A 794
ILE A 787
LEU A 572
TYR A 573
ALA A 631
 None
 1.33A 5fctB-4hu3A:
undetectable		 5fctB-4hu3A:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqq THYMIDYLATE SYNTHASE

(Caenorhabditis
elegans) 		PF00303
(Thymidylat_synt) 		5 LYS A  79
ILE A 110
CYH A 197
LEU A 223
TYR A 260
 D16  A 402 ( 4.5A)
D16  A 402 (-4.0A)
UMP  A 401 (-3.3A)
D16  A 402 (-3.7A)
D16  A 402 ( 4.2A)
 1.18A 5fctB-4iqqA:
42.3		 5fctB-4iqqA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqq THYMIDYLATE SYNTHASE

(Caenorhabditis
elegans) 		PF00303
(Thymidylat_synt) 		5 VAL A  81
ILE A 110
CYH A 197
LEU A 223
TYR A 260
 None
D16  A 402 (-4.0A)
UMP  A 401 (-3.3A)
D16  A 402 (-3.7A)
D16  A 402 ( 4.2A)
 0.84A 5fctB-4iqqA:
42.3		 5fctB-4iqqA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqq THYMIDYLATE SYNTHASE

(Caenorhabditis
elegans) 		PF00303
(Thymidylat_synt) 		5 VAL A  81
ILE A 110
TRP A 111
LEU A 194
LEU A 223
 None
D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
 0.92A 5fctB-4iqqA:
42.3		 5fctB-4iqqA:
62.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE

(Pseudomonas
savastanoi) 		PF01593
(Amino_oxidase) 		5 ILE A 551
LEU A 542
TYR A 507
MET A 495
ALA A 497
 None
 1.50A 5fctB-4iv9A:
undetectable		 5fctB-4iv9A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh7 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN

(Salmonella
enterica) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		5 VAL A 170
PHE A 169
LEU A  84
MET A 204
ALA A 198
 None
 1.13A 5fctB-4kh7A:
undetectable		 5fctB-4kh7A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kry ACETYL ESTERASE

(Escherichia
coli) 		PF07859
(Abhydrolase_3) 		5 VAL A 118
PHE A  88
ILE A 121
LEU A 125
ALA A 166
 None
None
None
None
SEB  A 165 ( 3.4A)
 1.26A 5fctB-4kryA:
undetectable		 5fctB-4kryA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pb6 VP1

(Feline
calicivirus) 		PF00915
(Calici_coat) 		5 VAL A 254
PHE A 256
ILE A 289
LEU A 652
ALA A 192
 None
 1.50A 5fctB-4pb6A:
undetectable		 5fctB-4pb6A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 TRP A  53
LEU A 130
CYH A  64
LEU A 156
ALA A 334
 None
 1.47A 5fctB-4ppzA:
undetectable		 5fctB-4ppzA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pr3 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE

(Brucella
melitensis) 		PF01048
(PNP_UDP_1) 		5 VAL A 197
LEU A 183
LEU A  63
MET A  13
ALA A  14
 None
 1.29A 5fctB-4pr3A:
undetectable		 5fctB-4pr3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2m ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,B-CELL
LYMPHOMA 6 PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		5 VAL A 158
PHE A 166
LEU A 142
LEU A 173
ALA A 175
 None
 1.45A 5fctB-4u2mA:
undetectable		 5fctB-4u2mA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		5 VAL A 538
PHE A 537
LEU A 526
TYR A 522
ALA A 583
 None
 1.50A 5fctB-4w8yA:
undetectable		 5fctB-4w8yA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgx MOLINATE HYDROLASE

(Gulosibacter
molinativorax) 		PF01979
(Amidohydro_1) 		5 VAL A  67
LEU A  59
LEU A 339
MET A 374
ALA A 387
 None
 1.42A 5fctB-4wgxA:
undetectable		 5fctB-4wgxA:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xsc THYMIDYLATE SYNTHASE

(Human
alphaherpesvirus
3) 		PF00303
(Thymidylat_synt) 		6 VAL A  67
PHE A  68
ILE A  96
CYH A 183
LEU A 209
TYR A 246
 None
None
1PE  A1002 (-4.6A)
BVP  A1001 (-3.4A)
None
BVP  A1001 (-4.5A)
 0.75A 5fctB-4xscA:
40.6		 5fctB-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xsc THYMIDYLATE SYNTHASE

(Human
alphaherpesvirus
3) 		PF00303
(Thymidylat_synt) 		6 VAL A  67
PHE A  68
ILE A  96
LEU A 180
LEU A 209
TYR A 246
 None
None
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-4.5A)
 0.80A 5fctB-4xscA:
40.6		 5fctB-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xsc THYMIDYLATE SYNTHASE

(Human
alphaherpesvirus
3) 		PF00303
(Thymidylat_synt) 		6 VAL A  67
PHE A  68
ILE A  96
TRP A  97
LEU A 180
LEU A 209
 None
None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
 0.81A 5fctB-4xscA:
40.6		 5fctB-4xscA:
65.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF09818
(ABC_ATPase) 		5 VAL A  61
ILE A 207
LEU A 214
CYH A  85
ALA A 154
 None
 1.27A 5fctB-4yj1A:
undetectable		 5fctB-4yj1A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		5 PHE A 139
ILE A 168
TRP A 169
LEU A  94
ALA A 127
 None
None
None
None
SUV  A2001 ( 4.5A)
 1.46A 5fctB-4zj8A:
undetectable		 5fctB-4zj8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5

(Homo sapiens;
Homo sapiens) 		PF12859
(ANAPC1)
PF12862
(ANAPC5) 		5 VAL O 267
ILE A 153
LEU A 187
CYH A 129
ALA A 171
 None
 1.44A 5fctB-5a31O:
undetectable		 5fctB-5a31O:
17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5by6 THYMIDYLATE SYNTHASE

(Trichinella
spiralis) 		PF00303
(Thymidylat_synt) 		5 VAL A  73
PHE A  74
CYH A 189
LEU A 215
TYR A 252
 None
None
UMP  A 401 (-3.4A)
None
UMP  A 401 (-4.6A)
 0.74A 5fctB-5by6A:
42.2		 5fctB-5by6A:
63.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5by6 THYMIDYLATE SYNTHASE

(Trichinella
spiralis) 		PF00303
(Thymidylat_synt) 		5 VAL A  73
PHE A  74
ILE A 102
TRP A 103
LEU A 186
 None
None
DTT  A 402 ( 4.3A)
DTT  A 402 ( 4.1A)
None
 0.78A 5fctB-5by6A:
42.2		 5fctB-5by6A:
63.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum) 		PF02055
(Glyco_hydro_30) 		5 VAL A 261
ILE A 176
TYR A 216
MET A 257
ALA A 219
 None
 1.47A 5fctB-5cxpA:
undetectable		 5fctB-5cxpA:
19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h3a ORF70

(Human
gammaherpesvirus
8) 		PF00303
(Thymidylat_synt) 		5 VAL A 103
PHE A 104
ILE A 132
CYH A 219
TYR A 282
 None
D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
UMP  A 402 (-3.4A)
UMP  A 402 (-4.5A)
 0.73A 5fctB-5h3aA:
43.0		 5fctB-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h3a ORF70

(Human
gammaherpesvirus
8) 		PF00303
(Thymidylat_synt) 		5 VAL A 103
PHE A 104
ILE A 132
LEU A 216
TYR A 282
 None
D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
UMP  A 402 (-4.5A)
 0.83A 5fctB-5h3aA:
43.0		 5fctB-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h3a ORF70

(Human
gammaherpesvirus
8) 		PF00303
(Thymidylat_synt) 		5 VAL A 103
PHE A 104
ILE A 132
TRP A 133
LEU A 216
 None
D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
None
 0.70A 5fctB-5h3aA:
43.0		 5fctB-5h3aA:
71.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ht7 UNCHARACTERIZED
PROTEIN

(Methanothrix
thermoacetophila) 		PF00030
(Crystall) 		5 VAL A  39
PHE A  60
ILE A  68
LEU A   4
ALA A  32
 None
 1.49A 5fctB-5ht7A:
undetectable		 5fctB-5ht7A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2

(Planctopirus
limnophila) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 VAL A  96
LEU A 316
LEU A  76
MET A  74
ALA A  73
 None
 1.26A 5fctB-5i2hA:
undetectable		 5fctB-5i2hA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE SUBUNIT
ALPHA

(Caldalkalibacillus
thermarum) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 ILE A 129
LEU A  52
MET A  60
MET A  62
ALA A  63
 None
 1.24A 5fctB-5ik2A:
undetectable		 5fctB-5ik2A:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j7w THYMIDYLATE SYNTHASE

(Enterococcus
faecalis) 		PF00303
(Thymidylat_synt) 		5 LYS A  49
VAL A  51
CYH A 197
LEU A 223
TYR A 260
 None
None
SO4  A 401 ( 3.9A)
None
None
 0.62A 5fctB-5j7wA:
34.5		 5fctB-5j7wA:
48.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2

(Saccharomyces
cerevisiae) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		5 VAL A 158
ILE A 177
LEU A 199
LEU A  53
ALA A  57
 GSH  A 401 (-4.0A)
None
None
None
None
 1.33A 5fctB-5lkdA:
undetectable		 5fctB-5lkdA:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Toxoplasma
gondii) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		12 LYS A 371
VAL A 373
PHE A 374
ILE A 402
TRP A 403
LEU A 486
CYH A 489
LEU A 516
TYR A 553
MET A 606
MET A 608
ALA A 609
 CB3  A 703 (-3.2A)
CB3  A 703 ( 3.6A)
None
CB3  A 703 (-3.4A)
CB3  A 703 (-4.1A)
UMP  A 701 (-4.7A)
UMP  A 701 (-2.9A)
CB3  A 703 (-3.7A)
UMP  A 701 (-4.4A)
None
CB3  A 703 (-3.6A)
CB3  A 703 (-3.8A)
 0.50A 5fctB-5t0lA:
45.5		 5fctB-5t0lA:
35.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9o B-CELL LYMPHOMA 6
PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		5 VAL A  35
PHE A  43
LEU A  19
LEU A  50
ALA A  52
 None
 1.40A 5fctB-5x9oA:
undetectable		 5fctB-5x9oA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azt ASPARAGINYL
ENDOPEPTIDASE 1

(Helianthus
annuus) 		no annotation 5 VAL A  98
ILE A 171
LEU A 234
LEU A 173
ALA A 238
 None
 1.49A 5fctB-6aztA:
undetectable		 5fctB-6aztA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cdz THYMIDYLATE SYNTHASE

(Escherichia
coli) 		no annotation 6 LYS A  48
ILE A  79
LEU A 143
CYH A 146
LEU A 172
TYR A 209
 CB3  A 701 ( 4.8A)
CB3  A 701 (-3.9A)
None
UMP  A 702 (-3.4A)
CB3  A 701 (-3.5A)
UMP  A 702 ( 4.2A)
 1.06A 5fctB-6cdzA:
37.7		 5fctB-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7g TYROSINE
PHENOL-LYASE

(Pantoea
agglomerans) 		PF01212
(Beta_elim_lyase) 		3 ASN A 151
ASP A 327
GLY A 326
 None
 0.62A 5fctB-1c7gA:
0.0		 5fctB-1c7gA:
20.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ci7 PROTEIN (THYMIDYLATE
SYNTHASE)

(Pneumocystis
carinii) 		PF00303
(Thymidylat_synt) 		3 ASN A  90
ASP A 202
GLY A 206
 CB3  A 768 (-3.8A)
CB3  A 768 ( 3.6A)
UMP  A 767 (-3.7A)
 0.63A 5fctB-1ci7A:
44.0		 5fctB-1ci7A:
58.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE

(Providencia
rettgeri) 		PF01804
(Penicil_amidase) 		3 ASN B 315
ASP B 440
GLY B 439
 None
 0.65A 5fctB-1cp9B:
0.0		 5fctB-1cp9B:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1p TYROSINE PHOSPHATASE

(Saccharomyces
cerevisiae) 		PF01451
(LMWPc) 		3 ASN A 122
ASP A 118
GLY A 117
 None
 0.51A 5fctB-1d1pA:
0.0		 5fctB-1d1pA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dql IGM MEZ
IMMUNOGLOBULIN

(Homo sapiens) 		PF07686
(V-set) 		3 ASN H 100
ASP H  54
GLY H  55
 None
 0.63A 5fctB-1dqlH:
undetectable		 5fctB-1dqlH:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
SMALL SUBUNIT

(Desulfovibrio
desulfuricans) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		3 ASN A 255
ASP A 135
GLY A 132
 H2S  A 904 (-4.9A)
None
None
 0.67A 5fctB-1e3dA:
0.0		 5fctB-1e3dA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1c CYTOCHROME C549

(Arthrospira
maxima) 		PF14495
(Cytochrom_C550) 		3 ASN A  49
ASP A  83
GLY A  84
 HEM  A 200 ( 4.8A)
None
None
 0.56A 5fctB-1f1cA:
undetectable		 5fctB-1f1cA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ftg APOFLAVODOXIN

(Nostoc sp. PCC
7119) 		PF00258
(Flavodoxin_1) 		3 ASN A  58
ASP A  65
GLY A   9
 None
 0.65A 5fctB-1ftgA:
0.0		 5fctB-1ftgA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882

(Lophonetta
specularioides) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		3 ASN A 263
ASP A 149
GLY A 254
 None
 0.62A 5fctB-1h8lA:
0.0		 5fctB-1h8lA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkg HEXOKINASE A

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 ASN A 111
ASP A  73
GLY A  72
 None
 0.51A 5fctB-1hkgA:
1.0		 5fctB-1hkgA:
19.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvy THYMIDYLATE SYNTHASE

(Homo sapiens) 		PF00303
(Thymidylat_synt) 		3 ASN A 112
ASP A 218
GLY A 222
 D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
 0.44A 5fctB-1hvyA:
48.2		 5fctB-1hvyA:
93.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhy METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		3 ASN B 245
ASP B 309
GLY B 313
 None
 0.64A 5fctB-1mhyB:
undetectable		 5fctB-1mhyB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mz5 SIALIDASE

(Trypanosoma
rangeli) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		3 ASN A 119
ASP A 126
GLY A 127
 None
 0.46A 5fctB-1mz5A:
undetectable		 5fctB-1mz5A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ng0 COAT PROTEIN

(Cocksfoot
mottle virus) 		PF00729
(Viral_coat) 		3 ASN A 158
ASP A 164
GLY A 177
 ASN  A 158 ( 0.6A)
ASP  A 164 ( 0.6A)
GLY  A 177 ( 0.0A)
 0.67A 5fctB-1ng0A:
undetectable		 5fctB-1ng0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npu PROGRAMMED CELL
DEATH PROTEIN 1

(Mus musculus) 		PF07686
(V-set) 		3 ASN A  83
ASP A  79
GLY A  14
 None
 0.60A 5fctB-1npuA:
undetectable		 5fctB-1npuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p6s RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00169
(PH) 		3 ASN A  54
ASP A  32
GLY A  33
 None
 0.66A 5fctB-1p6sA:
undetectable		 5fctB-1p6sA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		3 ASN A 219
ASP A 375
GLY A 374
 None
 0.66A 5fctB-1qb4A:
undetectable		 5fctB-1qb4A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcw FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae) 		PF01070
(FMN_dh) 		3 ASN A 157
ASP A 282
GLY A 350
 None
 0.61A 5fctB-1qcwA:
undetectable		 5fctB-1qcwA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)

(Homo sapiens) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		3 ASN A 179
ASP A 134
GLY A 133
 None
ZN  A 262 ( 2.4A)
None
 0.64A 5fctB-1qh5A:
undetectable		 5fctB-1qh5A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF16363
(GDP_Man_Dehyd) 		3 ASN A  80
ASP A  59
GLY A  58
 None
NDP  A1501 (-2.9A)
None
 0.62A 5fctB-1rpnA:
undetectable		 5fctB-1rpnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		3 ASN A 286
ASP A 293
GLY A 294
 None
 0.62A 5fctB-1rt8A:
undetectable		 5fctB-1rt8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Toxoplasma
gondii) 		no annotation 3 ASN D 194
ASP D 220
GLY D 232
 None
 0.65A 5fctB-1upfD:
undetectable		 5fctB-1upfD:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		3 ASN A 149
ASP A 118
GLY A 145
 None
 0.67A 5fctB-1wd3A:
undetectable		 5fctB-1wd3A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwz HYPOTHETICAL PROTEIN
PH1933

(Pyrococcus
horikoshii) 		PF00583
(Acetyltransf_1) 		3 ASN A 118
ASP A  55
GLY A  56
 None
 0.55A 5fctB-1wwzA:
undetectable		 5fctB-1wwzA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		3 ASN A 201
ASP A 213
GLY A 178
 None
 0.47A 5fctB-1x3lA:
undetectable		 5fctB-1x3lA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10) 		3 ASN A 661
ASP A 648
GLY A 653
 None
 0.67A 5fctB-1xyzA:
undetectable		 5fctB-1xyzA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE

(Ipomoea batatas) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		3 ASN A 168
ASP A 134
GLY A 162
 None
FE  A 429 ( 3.4A)
None
 0.68A 5fctB-1xzwA:
undetectable		 5fctB-1xzwA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd8 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3

(Homo sapiens) 		PF03127
(GAT) 		3 ASN G 285
ASP G 278
GLY G 277
 None
 0.66A 5fctB-1yd8G:
undetectable		 5fctB-1yd8G:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)

(Mycobacterium
tuberculosis) 		PF00484
(Pro_CA) 		3 ASN A   3
ASP A  68
GLY A  67
 None
 0.63A 5fctB-2a5vA:
undetectable		 5fctB-2a5vA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaf ARGININE DEIMINASE

(Pseudomonas
aeruginosa) 		PF02274
(Amidinotransf) 		3 ASN A 379
ASP A 357
GLY A 344
 None
 0.65A 5fctB-2aafA:
undetectable		 5fctB-2aafA:
21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		3 ASN A 104
ASP A 219
GLY A 223
 CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 ( 3.2A)
 0.21A 5fctB-2aazA:
undetectable		 5fctB-2aazA:
59.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwm PSATHYRELLA VELUTINA
LECTIN PVL

(Lacrymaria
velutina) 		PF13517
(VCBS) 		3 ASN A  34
ASP A 347
GLY A 348
 None
CA  A1401 (-3.0A)
None
 0.63A 5fctB-2bwmA:
undetectable		 5fctB-2bwmA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwm PSATHYRELLA VELUTINA
LECTIN PVL

(Lacrymaria
velutina) 		PF13517
(VCBS) 		3 ASN A 255
ASP A 181
GLY A 182
 None
CA  A1402 (-3.0A)
None
 0.55A 5fctB-2bwmA:
undetectable		 5fctB-2bwmA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2can ORNITHINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00202
(Aminotran_3) 		3 ASN A 378
ASP A 350
GLY A 273
 None
 0.61A 5fctB-2canA:
undetectable		 5fctB-2canA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cod CENTAURIN-DELTA 1

(Homo sapiens) 		PF00169
(PH) 		3 ASN A  88
ASP A  65
GLY A  64
 None
 0.66A 5fctB-2codA:
undetectable		 5fctB-2codA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cpt VACUOLAR SORTING
PROTEIN 4B

(Homo sapiens) 		PF04212
(MIT) 		3 ASN A 107
ASP A 110
GLY A 111
 None
 0.44A 5fctB-2cptA:
undetectable		 5fctB-2cptA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf7 CLASS B ACID
PHOSPHATASE

(Escherichia
coli) 		PF03767
(Acid_phosphat_B) 		3 ASN A 150
ASP A  44
GLY A 166
 None
MG  A 700 ( 2.5A)
None
 0.61A 5fctB-2hf7A:
undetectable		 5fctB-2hf7A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icg LIN2918 PROTEIN

(Listeria
innocua) 		PF14568
(SUKH_6) 		3 ASN A 133
ASP A  91
GLY A  90
 None
 0.47A 5fctB-2icgA:
undetectable		 5fctB-2icgA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l2b STICHOLYSIN-2

(Stichodactyla
helianthus) 		PF06369
(Anemone_cytotox) 		3 ASN A 138
ASP A 143
GLY A 142
 None
 0.47A 5fctB-2l2bA:
undetectable		 5fctB-2l2bA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 ASN A 113
ASP A 257
GLY A 261
 None
 0.63A 5fctB-2nq5A:
undetectable		 5fctB-2nq5A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE

(Paramecium
bursaria
Chlorella virus
1) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 ASN A   6
ASP A 343
GLY A 342
 None
 0.65A 5fctB-2nv9A:
undetectable		 5fctB-2nv9A:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		3 ASN A 319
ASP A 426
GLY A 430
 CB3  A 604 ( 4.3A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
 0.34A 5fctB-2oipA:
44.9		 5fctB-2oipA:
34.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		3 ASN A 259
ASP A  49
GLY A  50
 None
 0.66A 5fctB-2oxtA:
undetectable		 5fctB-2oxtA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfe CALPAIN-7

(Homo sapiens) 		PF01067
(Calpain_III) 		3 ASN A 706
ASP A 764
GLY A 763
 None
None
BR  A  11 ( 4.1A)
 0.64A 5fctB-2qfeA:
undetectable		 5fctB-2qfeA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qri H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN K-B ALPHA
CHAIN, BETA-2
MICROGLOBULIN,
OVALBUMIN-DERIVED
PEPTIDE

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 ASN A  21
ASP A 238
GLY A 237
 None
 0.66A 5fctB-2qriA:
undetectable		 5fctB-2qriA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5g CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 2

(Homo sapiens) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		3 ASN A 237
ASP A  23
GLY A  24
 None
 0.67A 5fctB-2r5gA:
undetectable		 5fctB-2r5gA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uu7 GLUTAMINE SYNTHETASE

(Canis lupus) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		3 ASN A 112
ASP A 216
GLY A 215
 None
 0.67A 5fctB-2uu7A:
undetectable		 5fctB-2uu7A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		3 ASN G1383
ASP G1344
GLY G1345
 None
 0.66A 5fctB-2uv8G:
undetectable		 5fctB-2uv8G:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v35 ELASTASE-1

(Sus scrofa) 		PF00089
(Trypsin) 		3 ASN A 133
ASP A 186
GLY A 185
 None
 0.62A 5fctB-2v35A:
undetectable		 5fctB-2v35A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa5 FILAMIN-B

(Homo sapiens) 		PF00307
(CH) 		3 ASN A 160
ASP A 167
GLY A 168
 None
 0.65A 5fctB-2wa5A:
undetectable		 5fctB-2wa5A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN

(Shewanella
oneidensis) 		PF00854
(PTR2) 		3 ASN A  86
ASP A  79
GLY A  75
 None
 0.60A 5fctB-2xutA:
undetectable		 5fctB-2xutA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF03714
(PUD) 		3 ASN A 817
ASP A 736
GLY A 737
 None
 0.62A 5fctB-2ya1A:
undetectable		 5fctB-2ya1A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 ASN A 362
ASP A 281
GLY A 282
 None
 0.50A 5fctB-2ya2A:
undetectable		 5fctB-2ya2A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yun NOSTRIN

(Homo sapiens) 		PF14604
(SH3_9) 		3 ASN A  65
ASP A  30
GLY A  29
 None
 0.48A 5fctB-2yunA:
undetectable		 5fctB-2yunA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8l UNCHARACTERIZED
PROTEIN

(Novosphingobium
aromaticivorans) 		PF13577
(SnoaL_4) 		3 ASN A  63
ASP A 102
GLY A 100
 None
 0.68A 5fctB-3b8lA:
undetectable		 5fctB-3b8lA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkh LYTIC
TRANSGLYCOSYLASE

(Pseudomonas
virus phiKZ) 		PF01464
(SLT)
PF01471
(PG_binding_1) 		3 ASN A  21
ASP A  31
GLY A  32
 None
 0.52A 5fctB-3bkhA:
undetectable		 5fctB-3bkhA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3y O-METHYLTRANSFERASE

(Mesembryanthemum
crystallinum) 		PF01596
(Methyltransf_3) 		3 ASN A 210
ASP A 228
GLY A  13
 None
 0.53A 5fctB-3c3yA:
undetectable		 5fctB-3c3yA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdk SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
B

(Bacillus
subtilis) 		PF01144
(CoA_trans) 		3 ASN B 134
ASP B 112
GLY B 111
 None
 0.31A 5fctB-3cdkB:
undetectable		 5fctB-3cdkB:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clq UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF06545
(DUF1116) 		3 ASN A 437
ASP A 241
GLY A 240
 None
 0.61A 5fctB-3clqA:
undetectable		 5fctB-3clqA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doh ESTERASE

(Thermotoga
maritima) 		PF02230
(Abhydrolase_2) 		3 ASN A 118
ASP A 372
GLY A 375
 None
 0.57A 5fctB-3dohA:
undetectable		 5fctB-3dohA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4v NADH:FMN
OXIDOREDUCTASE LIKE
PROTEIN

(Methylobacillus
flagellatus) 		PF01613
(Flavin_Reduct) 		3 ASN A  87
ASP A 161
GLY A 160
 FMN  A 300 ( 4.5A)
None
None
 0.61A 5fctB-3e4vA:
undetectable		 5fctB-3e4vA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD

(Escherichia
coli) 		PF03958
(Secretin_N) 		3 ASN A 133
ASP A 101
GLY A 100
 None
 0.63A 5fctB-3ezjA:
undetectable		 5fctB-3ezjA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7p PLECTIN-1

(Homo sapiens) 		PF00307
(CH) 		3 ASN A 209
ASP A 216
GLY A 217
 None
EDO  A 294 (-3.6A)
None
 0.64A 5fctB-3f7pA:
undetectable		 5fctB-3f7pA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fky GLUTAMINE SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		3 ASN A 109
ASP A 213
GLY A 212
 None
 0.64A 5fctB-3fkyA:
undetectable		 5fctB-3fkyA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ASN A 446
ASP A 504
GLY A 442
 None
 0.67A 5fctB-3gwjA:
undetectable		 5fctB-3gwjA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdl ROYAL PALM TREE
PEROXIDASE

(Roystonea regia) 		PF00141
(peroxidase) 		3 ASN A 181
ASP A 248
GLY A 243
 None
 0.62A 5fctB-3hdlA:
undetectable		 5fctB-3hdlA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijl MUCONATE
CYCLOISOMERASE

(Bacteroides
thetaiotaomicron) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASN A 226
ASP A 348
GLY A 325
 MG  A 386 ( 4.6A)
PRO  A 384 (-3.4A)
None
 0.67A 5fctB-3ijlA:
undetectable		 5fctB-3ijlA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4

(Homo sapiens) 		PF00557
(Peptidase_M24) 		3 ASN A 120
ASP A 196
GLY A 197
 None
 0.61A 5fctB-3j2iA:
undetectable		 5fctB-3j2iA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4w UNCHARACTERIZED
PROTEIN BB4693

(Bordetella
bronchiseptica) 		PF04909
(Amidohydro_2) 		3 ASN A  68
ASP A  79
GLY A  14
 None
 0.66A 5fctB-3k4wA:
undetectable		 5fctB-3k4wA:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		3 ASN A 310
ASP A 416
GLY A 420
 GOL  A 516 (-3.7A)
None
None
 0.26A 5fctB-3kjrA:
45.3		 5fctB-3kjrA:
34.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3li9 HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE

(Methanosarcina
mazei) 		PF02743
(dCache_1) 		3 ASN A  56
ASP A 289
GLY A 288
 None
 0.64A 5fctB-3li9A:
undetectable		 5fctB-3li9A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm8 THIAMINE
PYROPHOSPHOKINASE

(Bacillus
subtilis) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		3 ASN A 113
ASP A  32
GLY A  34
 None
 0.57A 5fctB-3lm8A:
undetectable		 5fctB-3lm8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		3 ASN A 433
ASP A  49
GLY A  50
 None
 0.46A 5fctB-3lscA:
undetectable		 5fctB-3lscA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxr IPGB2

(Shigella
flexneri) 		PF03278
(IpaB_EvcA) 		3 ASN F  76
ASP F  92
GLY F  91
 None
 0.62A 5fctB-3lxrF:
undetectable		 5fctB-3lxrF:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp2 NON-STRUCTURAL
PROTEIN 3

(Alphacoronavirus
1) 		PF08715
(Viral_protease) 		3 ASN A  65
ASP A  29
GLY A  76
 None
 0.67A 5fctB-3mp2A:
undetectable		 5fctB-3mp2A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx7 FAS APOPTOTIC
INHIBITORY MOLECULE
1

(Homo sapiens) 		PF06905
(FAIM1) 		3 ASN A  82
ASP A  14
GLY A  15
 None
 0.65A 5fctB-3mx7A:
undetectable		 5fctB-3mx7A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		3 ASN A 574
ASP A 531
GLY A 532
 None
 0.50A 5fctB-3nzqA:
undetectable		 5fctB-3nzqA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4r DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Homo sapiens) 		PF13561
(adh_short_C2) 		3 ASN A 120
ASP A  42
GLY A  43
 None
NAP  A 601 (-3.9A)
NAP  A 601 (-3.0A)
 0.60A 5fctB-3o4rA:
undetectable		 5fctB-3o4rA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogk CORONATINE-INSENSITI
VE PROTEIN 1

(Arabidopsis
thaliana) 		no annotation 3 ASN B 198
ASP B 299
GLY B 276
 None
 0.59A 5fctB-3ogkB:
undetectable		 5fctB-3ogkB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD

(Escherichia
coli) 		PF03958
(Secretin_N) 		3 ASN D 133
ASP D 101
GLY D 100
 None
 0.54A 5fctB-3ossD:
undetectable		 5fctB-3ossD:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf7 BENZOYL-COA
OXYGENASE COMPONENT
B

(Azoarcus
evansii) 		no annotation 3 ASN A 289
ASP A 410
GLY A 411
 None
 0.46A 5fctB-3pf7A:
undetectable		 5fctB-3pf7A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnk PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ASN A 256
ASP A 241
GLY A 242
 None
 0.63A 5fctB-3qnkA:
undetectable		 5fctB-3qnkA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rha PUTRESCINE OXIDASE

(Paenarthrobacter
aurescens) 		PF01593
(Amino_oxidase) 		3 ASN A 166
ASP A  96
GLY A  97
 None
 0.61A 5fctB-3rhaA:
undetectable		 5fctB-3rhaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		3 ASN A 161
ASP A 290
GLY A 266
 None
 0.58A 5fctB-3sggA:
undetectable		 5fctB-3sggA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl1 ARGINASE

(Plasmodium
falciparum) 		PF00491
(Arginase) 		3 ASN A 349
ASP A 383
GLY A 382
 None
 0.45A 5fctB-3sl1A:
undetectable		 5fctB-3sl1A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		3 ASN A  77
ASP A 127
GLY A 126
 EB4  A 328 (-3.5A)
EB4  A 328 (-3.5A)
EB4  A 328 (-3.4A)
 0.56A 5fctB-3tlkA:
undetectable		 5fctB-3tlkA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1x PUTATIVE GLYCOSYL
HYDROLASE

(Parabacteroides
distasonis) 		PF06439
(DUF1080) 		3 ASN A 185
ASP A 143
GLY A 115
 None
 0.55A 5fctB-3u1xA:
undetectable		 5fctB-3u1xA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uji FAB REGION OF THE
HEAVY CHAIN OF
ANTI-HIV-1 V3
MONOCLONAL ANTIBODY
2558

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASN H  31
ASP H 100
GLY H  99
 None
 0.64A 5fctB-3ujiH:
undetectable		 5fctB-3ujiH:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ul4 CELLULOSOME ENZYME,
DOCKERIN TYPE I

(Ruminiclostridium
thermocellum) 		PF00404
(Dockerin_1) 		3 ASN B   5
ASP B  44
GLY B  45
 None
CA  B  66 (-2.9A)
None
 0.43A 5fctB-3ul4B:
undetectable		 5fctB-3ul4B:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v1v 2-METHYLISOBORNEOL
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 3 ASN A 194
ASP A 162
GLY A 163
 None
 0.59A 5fctB-3v1vA:
undetectable		 5fctB-3v1vA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		3 ASN A   7
ASP A 137
GLY A 309
 None
FE2  A 601 ( 3.3A)
CA0  A 602 ( 4.0A)
 0.56A 5fctB-3vexA:
undetectable		 5fctB-3vexA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		3 ASN A  14
ASP A 137
GLY A 309
 None
FE2  A 601 ( 3.3A)
CA0  A 602 ( 4.0A)
 0.63A 5fctB-3vexA:
undetectable		 5fctB-3vexA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo) 		PF00082
(Peptidase_S8) 		3 ASN A 247
ASP A 200
GLY A 142
 None
 0.53A 5fctB-3vtaA:
undetectable		 5fctB-3vtaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0u TAIL FIBER PROTEIN

(Escherichia
virus T7) 		PF12604
(gp37_C) 		3 ASN A 546
ASP A 520
GLY A 521
 None
 0.45A 5fctB-4a0uA:
undetectable		 5fctB-4a0uA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE

(Homo sapiens) 		PF02668
(TauD)
PF06155
(DUF971) 		3 ASN A 333
ASP A 228
GLY A 227
 None
 0.57A 5fctB-4bhiA:
undetectable		 5fctB-4bhiA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1i BETA-GALACTOSIDASE,
PUTATIVE, BGL35A

(Cellvibrio
japonicus) 		PF02449
(Glyco_hydro_42) 		3 ASN A 392
ASP A 353
GLY A 387
 None
 0.61A 5fctB-4d1iA:
undetectable		 5fctB-4d1iA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dix PLECTIN-RELATED
PROTEIN

(Arabidopsis
thaliana) 		PF16709
(SCAB-IgPH) 		3 ASN A 439
ASP A 284
GLY A 285
 None
 0.45A 5fctB-4dixA:
undetectable		 5fctB-4dixA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dza LYSINE RACEMASE

(Proteus
mirabilis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 ASN A 244
ASP A 216
GLY A 169
 LLP  A  74 ( 4.5A)
None
None
 0.55A 5fctB-4dzaA:
undetectable		 5fctB-4dzaA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e09 PLASMID PARTITIONING
PROTEIN PARF

(Escherichia
coli) 		PF01656
(CbiA) 		3 ASN A  21
ASP A 187
GLY A 188
 None
 0.61A 5fctB-4e09A:
undetectable		 5fctB-4e09A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eex ALCOHOL
DEHYDROGENASE 1

(Lactococcus
lactis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASN A  52
ASP A  11
GLY A  12
 None
 0.66A 5fctB-4eexA:
undetectable		 5fctB-4eexA:
22.04