SIMILAR PATTERNS OF AMINO ACIDS FOR 5FA8_A_SAMA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpp DIPEPTIDE BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		3 THR A 182
ASP A  89
GLU A 161
 None
 0.79A 5fa8A-1dppA:
undetectable		 5fa8A-1dppA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT

(Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 THR A 295
ASP A 524
GLU A 519
 None
 0.74A 5fa8A-1e6vA:
0.0		 5fa8A-1e6vA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpi CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		3 THR A 102
ASP A  25
GLU A  18
 SAH  A 900 (-4.0A)
None
None
 0.78A 5fa8A-1kpiA:
13.5		 5fa8A-1kpiA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 THR A 893
ASP A 259
GLU A 235
 MGD  A1019 (-3.6A)
MGD  A1019 (-3.0A)
None
 0.77A 5fa8A-1kqfA:
2.4		 5fa8A-1kqfA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT

(Bos taurus) 		PF04045
(P34-Arc) 		3 THR D 246
ASP D  39
GLU D 150
 None
 0.84A 5fa8A-1u2vD:
undetectable		 5fa8A-1u2vD:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmr ISOPULLULANASE

(Aspergillus
niger) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		3 THR A  96
ASP A 161
GLU A 157
 None
 0.77A 5fa8A-1wmrA:
0.0		 5fa8A-1wmrA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy7 HYPOTHETICAL PROTEIN
PH1948

(Pyrococcus
horikoshii) 		PF05175
(MTS) 		3 THR A  30
ASP A  55
GLU A  79
 SAH  A1001 (-4.0A)
SAH  A1001 ( 4.5A)
SAH  A1001 (-2.8A)
 0.65A 5fa8A-1wy7A:
16.4		 5fa8A-1wy7A:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcv DIPHTHERIA TOXIN
REPRESSOR MUTANT

(Corynebacterium
diphtheriae) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C) 		3 THR A  14
ASP A 102
GLU A  83
 None
NI  A 252 (-3.0A)
None
 0.82A 5fa8A-1xcvA:
undetectable		 5fa8A-1xcvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF01717
(Meth_synt_2) 		3 THR A 303
ASP A 274
GLU A 272
 None
 0.68A 5fa8A-1ypxA:
1.0		 5fa8A-1ypxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a24 ENDOTHELIAL PAS
DOMAIN PROTEIN 1

(Homo sapiens) 		PF08447
(PAS_3) 		3 THR A  19
ASP A  15
GLU A  43
 None
 0.66A 5fa8A-2a24A:
undetectable		 5fa8A-2a24A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, LIGHT
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		3 THR L  59
ASP L  82
GLU L  39
 None
 0.62A 5fa8A-2d7tL:
undetectable		 5fa8A-2d7tL:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF01497
(Peripla_BP_2) 		3 THR A 294
ASP A 250
GLU A 209
 None
 0.68A 5fa8A-2etvA:
undetectable		 5fa8A-2etvA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fef HYPOTHETICAL PROTEIN
PA2201

(Pseudomonas
aeruginosa) 		PF08929
(DUF1911) 		3 THR A 143
ASP A 176
GLU A 197
 None
 0.75A 5fa8A-2fefA:
undetectable		 5fa8A-2fefA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpq BOTULINUM NEUROTOXIN
D LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 THR A 173
ASP A 167
GLU A 230
 None
None
ZN  A 500 ( 4.2A)
 0.81A 5fa8A-2fpqA:
undetectable		 5fa8A-2fpqA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gxf HYPOTHETICAL PROTEIN
YYBH

(Bacillus
subtilis) 		PF13474
(SnoaL_3) 		3 THR A 103
ASP A 125
GLU A  99
 None
 0.84A 5fa8A-2gxfA:
undetectable		 5fa8A-2gxfA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0i THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBG

(Escherichia
coli) 		PF13098
(Thioredoxin_2) 		3 THR A 145
ASP A 106
GLU A 189
 None
 0.57A 5fa8A-2h0iA:
undetectable		 5fa8A-2h0iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i50 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 16

(Homo sapiens) 		PF02148
(zf-UBP) 		3 THR A  80
ASP A  33
GLU A  71
 None
 0.65A 5fa8A-2i50A:
undetectable		 5fa8A-2i50A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iop CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 THR A 168
ASP A 171
GLU A 175
 None
 0.82A 5fa8A-2iopA:
undetectable		 5fa8A-2iopA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 THR A 394
ASP A 434
GLU A 475
 None
 0.77A 5fa8A-2iukA:
undetectable		 5fa8A-2iukA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 THR A 358
ASP A 275
GLU A 267
 None
None
ZN  A1291 (-2.3A)
 0.84A 5fa8A-2np0A:
undetectable		 5fa8A-2np0A:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		3 THR A 432
ASP A  30
GLU A  36
 None
CA  A7001 (-3.3A)
None
 0.83A 5fa8A-2pwhA:
undetectable		 5fa8A-2pwhA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vkw NEURAL CELL ADHESION
MOLECULE 1,140 KDA
ISOFORM

(Homo sapiens) 		PF00041
(fn3) 		3 THR A 595
ASP A 625
GLU A 600
 None
 0.85A 5fa8A-2vkwA:
undetectable		 5fa8A-2vkwA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xly CLOQ

(Streptomyces
roseochromogenus) 		PF11468
(PTase_Orf2) 		3 THR A  51
ASP A 260
GLU A 290
 None
 0.79A 5fa8A-2xlyA:
undetectable		 5fa8A-2xlyA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 THR B 151
ASP B 173
GLU B 216
 None
 0.78A 5fa8A-2y7cB:
11.5		 5fa8A-2y7cB:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		3 THR A  88
ASP A  99
GLU A 117
 None
 0.56A 5fa8A-2z1aA:
undetectable		 5fa8A-2z1aA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae;
Streptococcus
pneumoniae) 		PF03717
(PBP_dimer)
PF00905
(Transpeptidase) 		3 THR A 159
ASP B 313
GLU A  89
 None
 0.71A 5fa8A-2z2mA:
undetectable		 5fa8A-2z2mA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dni DEOXYRIBONUCLEASE I

(Bos taurus) 		PF03372
(Exo_endo_phos) 		3 THR A 203
ASP A 168
GLU A  39
 CA  A 281 (-3.9A)
None
None
 0.78A 5fa8A-3dniA:
1.6		 5fa8A-3dniA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)

(Geobacter
metallireducens) 		no annotation 3 THR A 232
ASP A 254
GLU A 279
 None
 0.57A 5fa8A-3e05A:
17.6		 5fa8A-3e05A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fii BOTULINUM NEUROTOXIN
TYPE F
FRAGMENT OF
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 2

(Clostridium
botulinum;
Homo sapiens) 		PF01742
(Peptidase_M27)
PF00957
(Synaptobrevin) 		3 THR A 243
ASP B  57
GLU B  55
 None
 0.81A 5fa8A-3fiiA:
undetectable		 5fa8A-3fiiA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE
ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas;
Desulfovibrio
gigas) 		PF00890
(FAD_binding_2)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9) 		3 THR B 133
ASP A 115
GLU A  42
 None
 0.85A 5fa8A-3gyxB:
undetectable		 5fa8A-3gyxB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		3 THR A 189
ASP A 250
GLU A 434
 None
 0.80A 5fa8A-3i04A:
undetectable		 5fa8A-3i04A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4z GLYCOSIDE HYDROLASE
FAMILY 9

(Ruminiclostridium
thermocellum) 		PF02018
(CBM_4_9)
PF02927
(CelD_N) 		3 THR A   8
ASP A 166
GLU A  19
 None
MG  A 290 (-2.6A)
MG  A 291 (-2.6A)
 0.78A 5fa8A-3k4zA:
undetectable		 5fa8A-3k4zA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT

(Methanosarcina
mazei) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 THR A 228
ASP A 249
GLU A 289
 None
 0.86A 5fa8A-3khkA:
undetectable		 5fa8A-3khkA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 THR A 201
ASP A 227
GLU A 255
 None
 0.44A 5fa8A-3lkdA:
11.7		 5fa8A-3lkdA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		3 THR A 206
ASP A 113
GLU A 185
 None
 0.82A 5fa8A-3m8uA:
undetectable		 5fa8A-3m8uA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		3 THR A 540
ASP A 630
GLU A 625
 None
 0.66A 5fa8A-3mc2A:
undetectable		 5fa8A-3mc2A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbi RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1

(Homo sapiens) 		PF08585
(RMI1_N) 		3 THR A 140
ASP A  60
GLU A 200
 None
 0.79A 5fa8A-3nbiA:
undetectable		 5fa8A-3nbiA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njr PRECORRIN-6Y
METHYLASE

(Rhodobacter
capsulatus) 		no annotation 3 THR A  18
ASP A  40
GLU A  63
 SAH  A 300 (-3.8A)
SAH  A 300 ( 4.8A)
SAH  A 300 (-2.6A)
 0.74A 5fa8A-3njrA:
18.1		 5fa8A-3njrA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nua PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Clostridium
perfringens) 		PF01259
(SAICAR_synt) 		3 THR A  34
ASP A 126
GLU A  91
 CIT  A 243 (-3.9A)
None
AMP  A 242 (-4.2A)
 0.84A 5fa8A-3nuaA:
undetectable		 5fa8A-3nuaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocm PUTATIVE MEMBRANE
PROTEIN

(Bordetella
parapertussis) 		PF00571
(CBS) 		3 THR A 443
ASP A 457
GLU A 454
 ADP  A 470 (-3.0A)
ADP  A 470 (-3.5A)
MG  A   7 ( 4.1A)
 0.86A 5fa8A-3ocmA:
undetectable		 5fa8A-3ocmA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p30 1281 FAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR L 163
ASP L  85
GLU L  83
 None
 0.85A 5fa8A-3p30L:
undetectable		 5fa8A-3p30L:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		3 THR A1279
ASP A1275
GLU A1248
 None
 0.81A 5fa8A-3pvlA:
undetectable		 5fa8A-3pvlA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9o EXOTOXIN A

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		3 THR A 247
ASP A 135
GLU A 110
 None
 0.77A 5fa8A-3q9oA:
undetectable		 5fa8A-3q9oA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rju BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE

(Yersinia pestis) 		PF00144
(Beta-lactamase) 		3 THR A  61
ASP A 162
GLU A 118
 None
 0.75A 5fa8A-3rjuA:
undetectable		 5fa8A-3rjuA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H

(Escherichia
coli) 		PF01795
(Methyltransf_5) 		3 THR A 178
ASP A 121
GLU A 185
 None
 0.82A 5fa8A-3tkaA:
13.7		 5fa8A-3tkaA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpa HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		3 THR A 189
ASP A  96
GLU A 168
 None
 0.85A 5fa8A-3tpaA:
undetectable		 5fa8A-3tpaA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		3 THR A  53
ASP A 193
GLU A 197
 None
 0.76A 5fa8A-3ubdA:
undetectable		 5fa8A-3ubdA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 THR A 201
ASP A 223
GLU A 261
 None
 0.76A 5fa8A-3ufbA:
11.7		 5fa8A-3ufbA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		3 THR A  99
ASP A 110
GLU A 128
 None
 0.62A 5fa8A-3zu0A:
undetectable		 5fa8A-3zu0A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Zymomonas
mobilis) 		PF00724
(Oxidored_FMN) 		3 THR A 335
ASP A 323
GLU A 330
 None
 0.81A 5fa8A-4a3uA:
undetectable		 5fa8A-4a3uA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 3 THR A 337
ASP A 414
GLU A 418
 None
 0.84A 5fa8A-4bb9A:
undetectable		 5fa8A-4bb9A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c13 UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--L-LYSINE LIGASE

(Staphylococcus
aureus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 THR A 404
ASP A 475
GLU A 460
 None
None
UML  A 598 (-3.1A)
 0.59A 5fa8A-4c13A:
4.0		 5fa8A-4c13A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cg4 PYRIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		3 THR A 771
ASP A 616
GLU A 784
 None
 0.66A 5fa8A-4cg4A:
undetectable		 5fa8A-4cg4A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d47 LEVANSUCRASE

(Erwinia
amylovora) 		PF02435
(Glyco_hydro_68) 		3 THR A 308
ASP A 317
GLU A  21
 None
 0.84A 5fa8A-4d47A:
undetectable		 5fa8A-4d47A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4z DEOXYHYPUSINE
HYDROXYLASE

(Homo sapiens) 		PF13646
(HEAT_2) 		3 THR A  81
ASP A 113
GLU A 117
 None
 0.58A 5fa8A-4d4zA:
undetectable		 5fa8A-4d4zA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ec7 VENOM NERVE GROWTH
FACTOR

(Naja atra) 		PF00243
(NGF) 		3 THR A  27
ASP A  82
GLU A  53
 None
 0.80A 5fa8A-4ec7A:
undetectable		 5fa8A-4ec7A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eku PROTEIN-TYROSINE
KINASE 2-BETA

(Homo sapiens) 		PF00373
(FERM_M) 		3 THR A 110
ASP A 116
GLU A 119
 None
 0.86A 5fa8A-4ekuA:
undetectable		 5fa8A-4ekuA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13

(Candida
albicans) 		PF09084
(NMT1) 		3 THR A   3
ASP A  58
GLU A 212
 None
 0.80A 5fa8A-4eswA:
undetectable		 5fa8A-4eswA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN

(Dyadobacter
fermentans) 		PF00501
(AMP-binding) 		3 THR A   8
ASP A 100
GLU A  98
 IOD  A 412 ( 4.6A)
None
None
 0.82A 5fa8A-4gs5A:
undetectable		 5fa8A-4gs5A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ina SACCHAROPINE
DEHYDROGENASE

(Wolinella
succinogenes) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 THR A 346
ASP A 169
GLU A 233
 None
 0.75A 5fa8A-4inaA:
undetectable		 5fa8A-4inaA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Schizosaccharomyces
pombe) 		PF12569
(NARP1) 		3 THR A 545
ASP A 220
GLU A 226
 None
 0.79A 5fa8A-4kvoA:
undetectable		 5fa8A-4kvoA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 3 THR A 337
ASP A 414
GLU A 418
 None
 0.84A 5fa8A-4lc9A:
undetectable		 5fa8A-4lc9A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2g L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
lavendulae) 		PF02668
(TauD) 		3 THR A 152
ASP A 255
GLU A 156
 None
None
FE  A 401 (-2.4A)
 0.65A 5fa8A-4m2gA:
undetectable		 5fa8A-4m2gA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzl MYOSIN A TAIL DOMAIN
INTERACTING PROTEIN

(Plasmodium
falciparum) 		no annotation 3 THR A 170
ASP A 177
GLU A 179
 None
 0.83A 5fa8A-4mzlA:
undetectable		 5fa8A-4mzlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		3 THR A 244
ASP A 287
GLU A 129
 None
None
UD1  A 400 (-3.6A)
 0.68A 5fa8A-4nesA:
undetectable		 5fa8A-4nesA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Psychrobacter
cryohalolentis) 		PF00561
(Abhydrolase_1) 		3 THR A 260
ASP A 140
GLU A 271
 None
 0.80A 5fa8A-4ns4A:
undetectable		 5fa8A-4ns4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN

(Streptomyces
pristinaespiralis) 		no annotation 3 THR A 221
ASP A 181
GLU A  87
 None
None
MG  A 901 (-2.6A)
 0.79A 5fa8A-4okmA:
undetectable		 5fa8A-4okmA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF12157
(DUF3591) 		3 THR A 875
ASP A 817
GLU A 551
 None
 0.86A 5fa8A-4oy2A:
undetectable		 5fa8A-4oy2A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqg GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
pneumoniae) 		PF00534
(Glycos_transf_1) 		3 THR A 222
ASP A  41
GLU A  18
 None
 0.86A 5fa8A-4pqgA:
5.6		 5fa8A-4pqgA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		3 THR A 739
ASP A 685
GLU A 667
 None
 0.75A 5fa8A-4q2cA:
undetectable		 5fa8A-4q2cA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 THR B 542
ASP B 415
GLU B 350
 None
 0.75A 5fa8A-4q4aB:
undetectable		 5fa8A-4q4aB:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfk ABC TRANSPORTER
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Pseudoalteromonas
sp. SM9913) 		no annotation 3 THR H 210
ASP H 117
GLU H 189
 None
 0.80A 5fa8A-4qfkH:
undetectable		 5fa8A-4qfkH:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl6 SACCHAROPINE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 THR A 365
ASP A 188
GLU A 252
 None
 0.81A 5fa8A-4rl6A:
undetectable		 5fa8A-4rl6A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 3 THR B 197
ASP B 181
GLU B 210
 None
 0.71A 5fa8A-4rziB:
5.7		 5fa8A-4rziB:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II

(Staphylococcus
aureus) 		PF01116
(F_bP_aldolase) 		3 THR A 140
ASP A 107
GLU A 135
 None
 0.85A 5fa8A-4to8A:
undetectable		 5fa8A-4to8A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvc DEXTRANSUCRASE

(Leuconostoc
mesenteroides) 		PF02324
(Glyco_hydro_70) 		3 THR A2223
ASP A2692
GLU A2181
 None
 0.79A 5fa8A-4tvcA:
undetectable		 5fa8A-4tvcA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wv3 ANTHRANILATE-COA
LIGASE

(Stigmatella
aurantiaca) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 THR A 178
ASP A 415
GLU A 295
 None
 0.82A 5fa8A-4wv3A:
undetectable		 5fa8A-4wv3A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhb SIALIDASE B

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		3 THR A 158
ASP A 217
GLU A 219
 None
 0.82A 5fa8A-4xhbA:
undetectable		 5fa8A-4xhbA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		3 THR A 869
ASP A 902
GLU A 944
 None
 0.77A 5fa8A-4xqkA:
11.0		 5fa8A-4xqkA:
7.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bxy RNA
METHYLTRANSFERASE

(Salinibacter
ruber) 		PF13847
(Methyltransf_31) 		3 THR A   7
ASP A  29
GLU A  53
 SAH  A 201 (-3.5A)
SAH  A 201 (-2.9A)
SAH  A 201 (-2.8A)
 0.12A 5fa8A-5bxyA:
26.8		 5fa8A-5bxyA:
46.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqr 7-HYDROXYMETHYL
CHLOROPHYLL A
REDUCTASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04422
(FrhB_FdhB_N)
PF04432
(FrhB_FdhB_C) 		3 THR A 110
ASP A 415
GLU A 408
 None
 0.77A 5fa8A-5dqrA:
undetectable		 5fa8A-5dqrA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejy MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum) 		PF00784
(MyTH4) 		3 THR A 258
ASP A 254
GLU A 227
 None
 0.83A 5fa8A-5ejyA:
undetectable		 5fa8A-5ejyA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1p PTMO8

(Streptomyces
platensis) 		PF13561
(adh_short_C2) 		3 THR A  45
ASP A  39
GLU A  62
 None
 0.83A 5fa8A-5f1pA:
6.3		 5fa8A-5f1pA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1q PERIPLASMIC
DIPEPTIDE TRANSPORT
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		3 THR A 210
ASP A 117
GLU A 189
 None
 0.80A 5fa8A-5f1qA:
undetectable		 5fa8A-5f1qA:
16.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE

(Sulfolobus
islandicus) 		PF13847
(Methyltransf_31) 		3 THR A  12
ASP A  34
GLU A  59
 SAH  A 201 (-3.4A)
SAH  A 201 (-2.9A)
SAH  A 201 (-2.9A)
 0.17A 5fa8A-5fadA:
24.4		 5fa8A-5fadA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gad SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY

(Escherichia
coli) 		PF00238
(Ribosomal_L14) 		3 THR l 356
ASP l 330
GLU l 396
 None
GNP  l1400 ( 4.7A)
None
 0.78A 5fa8A-5gadl:
undetectable		 5fa8A-5gadl:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 THR A 203
ASP A 365
GLU A 360
 None
 0.79A 5fa8A-5gj8A:
undetectable		 5fa8A-5gj8A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0r VP4 PROTEIN

(Cypovirus 1) 		no annotation 3 THR G 513
ASP G 532
GLU G 438
 None
 0.80A 5fa8A-5h0rG:
undetectable		 5fa8A-5h0rG:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 3 THR C 316
ASP C 361
GLU C 413
 SFG  C1002 (-4.0A)
SFG  C1002 ( 4.9A)
SFG  C1002 (-2.8A)
 0.54A 5fa8A-5hr4C:
11.0		 5fa8A-5hr4C:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j55 CAROTENOID OXYGENASE

(Novosphingobium
aromaticivorans) 		PF03055
(RPE65) 		3 THR A 253
ASP A 312
GLU A 322
 None
 0.72A 5fa8A-5j55A:
undetectable		 5fa8A-5j55A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 THR A1049
ASP A1027
GLU A 923
 None
ATP  A1200 (-4.1A)
None
 0.85A 5fa8A-5lpyA:
undetectable		 5fa8A-5lpyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 THR A1049
ASP A1027
GLU A 923
 None
ADP  A1200 (-3.4A)
None
 0.80A 5fa8A-5lpzA:
undetectable		 5fa8A-5lpzA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx8 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 THR A 241
ASP A 237
GLU A 544
 None
 0.67A 5fa8A-5lx8A:
undetectable		 5fa8A-5lx8A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii) 		no annotation 3 THR A 100
ASP A 118
GLU A 113
 None
 0.74A 5fa8A-5oc1A:
undetectable		 5fa8A-5oc1A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or7 CAPSID PROTEIN
CMRF35-LIKE MOLECULE
1

(Norwalk virus;
Mus musculus) 		no annotation
no annotation 		3 THR A 363
ASP C  98
GLU C  49
 None
NA  C 401 (-2.9A)
None
 0.79A 5fa8A-5or7A:
undetectable		 5fa8A-5or7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE
FERREDOXIN-NADP(+)
REDUCTASE SUBUNIT
ALPHA

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF10418
(DHODB_Fe-S_bind) 		3 THR A 251
ASP B 225
GLU A 270
 None
FES  B 302 (-2.5A)
None
 0.85A 5fa8A-5vj7A:
undetectable		 5fa8A-5vj7A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 3 THR A 173
ASP A 195
GLU A 233
 SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-2.7A)
 0.74A 5fa8A-5ybbA:
10.8		 5fa8A-5ybbA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygf GH18329P

(Drosophila
melanogaster) 		no annotation 3 THR A 433
ASP A 348
GLU A 331
 None
 0.83A 5fa8A-5ygfA:
undetectable		 5fa8A-5ygfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et8 -

(-) 		no annotation 3 THR A  26
ASP A  63
GLU A  18
 None
 0.74A 5fa8A-6et8A:
undetectable		 5fa8A-6et8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f49 -

(-) 		no annotation 3 THR A 135
ASP A 118
GLU A 206
 None
 0.85A 5fa8A-6f49A:
undetectable		 5fa8A-6f49A:
undetectable